MCID: SBS004
MIFTS: 48

Substance Dependence

Categories: Mental diseases

Aliases & Classifications for Substance Dependence

MalaCards integrated aliases for Substance Dependence:

Name: Substance Dependence 12 54 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9973
NCIt 49 C35458
SNOMED-CT 67 255338002
UMLS 71 C0038580 C0439857

Summaries for Substance Dependence

Disease Ontology : 12 A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance.

MalaCards based summary : Substance Dependence is related to drug dependence and tobacco addiction. An important gene associated with Substance Dependence is OPRM1 (Opioid Receptor Mu 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Lithium carbonate and Carbamazepine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Substance dependence, also known as drug dependence, is an adaptive state that develops from repeated... more...

Related Diseases for Substance Dependence

Diseases related to Substance Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 drug dependence 32.5 SLC6A4 SLC6A3 POMC OPRM1 OPRK1 OPRD1
2 tobacco addiction 32.2 SLC6A4 SLC6A3 OPRM1 MAOA DRD5 DRD4
3 alcohol dependence 31.9 SLC6A4 SLC6A3 POMC OPRM1 OPRK1 OPRD1
4 psychotic disorder 31.6 SLC6A4 SLC6A3 OPRM1 MAOA DRD5 DRD4
5 depression 31.5 SLC6A4 MAOA BDNF
6 smoking as a quantitative trait locus 3 31.4 CHRNA5 CHRNA3
7 avoidant personality disorder 31.3 SLC6A4 SLC6A3 MAOA HTR1B DRD4
8 personality disorder 31.3 SLC6A4 SLC6A3 MAOA HTR1B DRD4 DRD3
9 antisocial personality disorder 31.2 SLC6A4 SLC6A3 MAOA HTR1B DRD4 DRD2
10 borderline personality disorder 31.1 SLC6A4 SLC6A3 MAOA HTR1B DRD2 BDNF
11 conduct disorder 31.1 SLC6A4 SLC6A3 POMC MAOA DRD5 DRD4
12 acute stress disorder 31.1 SLC6A4 POMC BDNF
13 substance abuse 31.0 SLC6A4 SLC6A3 POMC OPRM1 OPRK1 OPRD1
14 alexithymia 31.0 SLC6A4 IL6 DRD2
15 generalized anxiety disorder 31.0 SLC6A4 SLC6A3 MAOA DRD2 BDNF
16 post-traumatic stress disorder 30.9 SLC6A4 POMC MAOA DRD2 CNR1 BDNF
17 opiate dependence 30.9 SLC6A4 SLC6A3 POMC OPRM1 OPRK1 OPRD1
18 neonatal abstinence syndrome 30.9 OPRM1 OPRK1 OPRD1
19 withdrawal disorder 30.8 POMC OPRM1 OPRK1 OPRD1 DRD2 CNR1
20 cocaine dependence 30.8 SLC6A4 SLC6A3 POMC OPRM1 OPRK1 OPRD1
21 alcohol use disorder 30.7 SLC6A4 SLC6A3 OPRM1 HTR1B DRD3 DRD2
22 melancholia 30.7 SLC6A4 POMC MAOA BDNF
23 dysthymic disorder 30.7 SLC6A4 MAOA BDNF
24 mental depression 30.7 SLC6A4 SLC6A3 POMC MAOA IL6 HTR1B
25 heroin dependence 30.7 SLC6A4 SLC6A3 OPRM1 OPRD1 MAOA DRD4
26 polysubstance abuse 30.7 DRD3 DRD2 CNR1
27 bipolar disorder 30.6 SLC6A4 SLC6A3 MAOA IL6 HTR1B DRD5
28 eating disorder 30.6 SLC6A4 SLC6A3 POMC OPRM1 DRD3 DRD2
29 attention deficit-hyperactivity disorder 30.6 SLC6A4 SLC6A3 OPRM1 MAOA IL6 HTR1B
30 mood disorder 30.6 SLC6A4 SLC6A3 POMC MAOA IL6 HTR1B
31 hypochondriasis 30.6 SLC6A4 POMC BDNF
32 bulimia nervosa 30.6 SLC6A4 POMC MAOA HTR1B DRD4 DRD2
33 cannabis abuse 30.6 OPRM1 DRD4 DRD2 CNR1 BDNF
34 social phobia 30.5 SLC6A4 MAOA DRD2 BDNF
35 phobic disorder 30.5 SLC6A4 POMC MAOA DRD2 BDNF
36 opioid addiction 30.5 OPRM1 OPRK1 OPRD1 DRD2
37 major depressive disorder 30.5 SLC6A4 SLC6A3 POMC OPRM1 MAOA IL6
38 pathological gambling 30.5 SLC6A4 SLC6A3 MAOA DRD5 DRD4 DRD3
39 oppositional defiant disorder 30.4 SLC6A4 SLC6A3 MAOA DRD4 DRD2
40 sleep disorder 30.4 SLC6A4 SLC6A3 POMC IL6 DRD2 BDNF
41 anxiety 30.4 SLC6A4 SLC6A3 POMC OPRM1 OPRK1 MAOA
42 bipolar i disorder 30.4 SLC6A4 DRD4 DRD3 DRD2 BDNF
43 anorexia nervosa 30.3 SLC6A4 POMC MAOA DRD4 CNR1 BDNF
44 agoraphobia 30.3 SLC6A4 MAOA BDNF
45 postpartum depression 30.3 SLC6A4 POMC MAOA BDNF
46 separation anxiety disorder 30.3 SLC6A4 SLC6A3 OPRM1 DRD4
47 panic disorder 30.3 SLC6A4 SLC6A3 POMC MAOA IL6 HTR1B
48 endogenous depression 30.2 SLC6A4 POMC MAOA IL6 BDNF
49 cocaine abuse 30.1 SLC6A4 SLC6A3 OPRK1 IL6 DRD3 DRD2
50 schizoaffective disorder 30.1 SLC6A4 DRD4 DRD3 DRD2 CNR1 BDNF

Graphical network of the top 20 diseases related to Substance Dependence:



Diseases related to Substance Dependence

Symptoms & Phenotypes for Substance Dependence

GenomeRNAi Phenotypes related to Substance Dependence according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.4 MAOA
2 Decreased viability GR00249-S 9.4 CHRNA3 OPRK1 SLC6A4
3 Decreased viability GR00381-A-1 9.4 ADH4 SLC6A4
4 Decreased viability GR00381-A-3 9.4 SLC6A4
5 Decreased viability GR00386-A-1 9.4 ADH1A CHRNB4 POMC
6 Decreased viability GR00402-S-2 9.4 OPRK1 OPRM1

MGI Mouse Phenotypes related to Substance Dependence:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.45 BDNF CHRNA3 CHRNA5 CHRNB4 CNR1 DRD2
2 homeostasis/metabolism MP:0005376 10.28 BDNF CHRNA3 CHRNB4 CNR1 DRD2 DRD3
3 growth/size/body region MP:0005378 10.21 BDNF CHRNA3 CHRNB4 CNR1 DRD2 DRD3
4 nervous system MP:0003631 10.19 BDNF CHRNA3 CHRNA5 CHRNB4 CNR1 DRD2
5 digestive/alimentary MP:0005381 10.18 BDNF CHRNA3 CHRNB4 CNR1 DRD2 DRD3
6 endocrine/exocrine gland MP:0005379 10.16 BDNF DRD2 DRD5 HTR1B IL6 OPRK1
7 integument MP:0010771 10.15 BDNF CHRNA5 CHRNB4 CNR1 DRD2 IL6
8 mortality/aging MP:0010768 10.13 BDNF CHRNA3 CHRNB4 CNR1 DRD2 DRD3
9 adipose tissue MP:0005375 10.05 CNR1 DRD2 DRD3 HTR1B IL6 OPRM1
10 no phenotypic analysis MP:0003012 9.76 BDNF CHRNA3 CNR1 DRD2 HTR1B OPRD1
11 renal/urinary system MP:0005367 9.5 CHRNA3 CHRNB4 DRD2 DRD3 DRD5 IL6
12 taste/olfaction MP:0005394 8.92 BDNF CNR1 DRD2 SLC6A3

Drugs & Therapeutics for Substance Dependence

Drugs for Substance Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 147)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lithium carbonate Approved Phase 4 554-13-2
2
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
3
Nicotine Approved Phase 4 54-11-5 942 89594
4
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
5
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
6
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
7
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
8
Citalopram Approved Phase 4 59729-33-8 2771
9
Sertraline Approved Phase 4 79617-96-2 68617
10
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
11
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
12
Choline Approved, Nutraceutical Phase 4 62-49-7 305
13 Analgesics Phase 4
14 Analgesics, Non-Narcotic Phase 4
15 Neurotransmitter Agents Phase 4
16 Central Nervous System Stimulants Phase 4
17 Anticonvulsants Phase 4
18 Antimetabolites Phase 4
19 Psychotropic Drugs Phase 4
20 Narcotics Phase 4
21 Antidepressive Agents Phase 4
22 Cytochrome P-450 Enzyme Inhibitors Phase 4
23 Serotonin Uptake Inhibitors Phase 4
24 Narcotic Antagonists Phase 4
25 Serotonin Receptor Agonists Phase 4
26 Cytidine Diphosphate Choline Phase 4
27 Antipsychotic Agents Phase 4
28 Dopamine Agents Phase 4
29 Dopamine Antagonists Phase 4
30 Dopamine agonists Phase 4
31 Serotonin 5-HT1 Receptor Agonists Phase 4
32 Lisdexamfetamine Dimesylate Phase 4
33 Gastrointestinal Agents Phase 4
34 Lecithin Phase 4
35 Hypolipidemic Agents Phase 4
36 Lipid Regulating Agents Phase 4
37
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
38
Topiramate Approved Phase 3 97240-79-4 5284627
39
Ethanol Approved Phase 3 64-17-5 702
40
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
41
Mineral oil Approved, Vet_approved Phase 2, Phase 3 8042-47-5
42
Nicotinamide Approved, Investigational Phase 2, Phase 3 98-92-0 936
43
Tocopherol Approved, Investigational Phase 2, Phase 3 1406-66-2, 54-28-4 14986
44
Memantine Approved, Investigational Phase 3 19982-08-2 4054
45
Promethazine Approved, Investigational Phase 2, Phase 3 60-87-7 4927
46
Suvorexant Approved, Investigational Phase 2, Phase 3 1030377-33-3
47
Diphenhydramine Approved, Investigational Phase 2, Phase 3 58-73-1, 147-24-0 3100
48
Phenol Approved, Experimental Phase 3 108-95-2 996
49
Liraglutide Approved Phase 3 204656-20-2 44147092
50
Glucagon Approved Phase 3 16941-32-5

Interventional clinical trials:

(show top 50) (show all 132)
# Name Status NCT ID Phase Drugs
1 Open Label Prophylaxis Study of Lithium Plus Extended- Release Carbamazepine (Equetro®) Combination for Rapid Cycling Bipolar Disorder Unknown status NCT00325286 Phase 4 Lithium Plus Extended- Release Carbamazepine
2 Depakote ER Therapy for Mania Comorbid With Substance Abuse Completed NCT00208195 Phase 4 Divalproex ER
3 Paroxetine Treatment in Outpatients With Comorbid PTSD and Substance Dependence Completed NCT00330239 Phase 4 Paroxetine CR
4 Aripiprazole (Abilify) Therapy for Reducing Comorbid Substance Abuse Completed NCT00208169 Phase 4 Aripiprazole
5 Pharmacogenetic Response to Naltrexone for Alcohol Dependence Completed NCT00831272 Phase 4 naltrexone;Placebo
6 Pilot Study of Vyvanse™ (Lisdexamfetamine Dimesylate) in Adolescents (Ages 11-15) With ADHD and an Older Sibling With ADHD and Substance Dependence Completed NCT00573534 Phase 4 Vyvanse
7 Group Cognitive Behavioral Therapy Versus Fluoxetine for Obsessive-Compulsive Disorder: a Randomized Open Trial for Any Patient. Completed NCT00680602 Phase 4 SSRI (fluoxetine, sertraline, paroxetine, citalopram)
8 Maintenance Study for Adolescent Depression Completed NCT00508859 Phase 4 Sertraline;placebo
9 A 12-week, Randomized, Double-blind, Parallel-group, Placebo-controlled Trial of Citicoline as an add-on Therapy Will be Conducted in 200 Outpatients With Bipolar I Disorder and Cocaine Dependence. Completed NCT00619723 Phase 4 Citicoline;Placebo
10 Randomized Clinical Trial Comparing a Medication, i.e., Sustained-Release Bupropion (Zyban®) With an Ultrashort (1 1/2 d) Manual-Based Psychotherapeutic Intervention, Psychodynamic Model Training® Completed NCT00484692 Phase 4 sustained-release bupropion (Zyban(R))
11 Improving Outcomes in Psychosis Associated With Substance Use Using Aripiprazole Withdrawn NCT01155544 Phase 4
12 Novel Pharmacotherapy for Dual Dependence Unknown status NCT00448825 Phase 3 Topiramate + Cognitive Behavioral Therapy;Placebo + Cognitive Behavioral Therapy
13 Linkage of Alcohol Abusers to Primary Care Completed NCT00278447 Phase 3
14 Incentive Programs for Female Substance Abusers Who Smoke Completed NCT00064922 Phase 2, Phase 3
15 Initialization of Methadone in Primary Care; a Randomized Intervention Research for Preventing HCV Transmission Practices. ANRS Methaville Completed NCT00657397 Phase 3 Methadone
16 A Multicentre, Placebo-controlled Trial of Eicosapentaenoic Acid (EPA) and Antioxidant Supplementation in the Treatment of Schizophrenia and Related Disorders Completed NCT00419146 Phase 2, Phase 3 Ethyl-eicosapentaenoic acid (EPA);Vitamins E + C
17 Psychopharmacotherapy in Multiple Substances Abuse / Dependence - the Pharmacological and Immunological Approach to the New Indication of Memantine Completed NCT01189214 Phase 3 Memantine
18 Efficacy/Effectiveness of Unhealthy Drug Use Screening/Brief Intervention Models Completed NCT00876941 Phase 3
19 Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities Completed NCT00403455 Phase 3 Paroxetine
20 A Randomized, Double-Blind, Placebo-Controlled Study of Quetiapine Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomanic Symptoms or Mild Manic Symptoms Completed NCT00277667 Phase 3 Quetiapine
21 Sensoril® (Ashwagandha) - A Standardized Extract From a Medicinal Plant - (Withania Somnifera) for Cognitive Enhancement in Persons With Bipolar Disorder: A Parallel Group, Randomized Double Blind, and Placebo Controlled Study Completed NCT00761761 Phase 3 Sensoril
22 Phase III Open Study of High Dose Escitalopram for the Treatment of Obsessive-Compulsive Disorder in Adults Completed NCT00305500 Phase 3 escitalopram
23 "A Randomized, Double-Blind, Placebo-Controlled Study of Divalproex Extended Release Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to- Severe Hypomania or Mild Mania" Completed NCT00278772 Phase 3 Divalproex
24 A Novel Approach to Cardiovascular Health by Optimizing Risk Management (ANCHOR): A Primary Prevention Initiative Examining The Impact Of Global Risk Factor Assessment & Management On Health Care In Nova Scotia Completed NCT01620996 Phase 3
25 The Efficacy of Suvorexant in the Residential Treatment of Patients With Substance Use Disorder and Insomnia: A Pilot Open Trial Enrolling by invitation NCT03412591 Phase 2, Phase 3 Suvorexant 20 mg
26 Liraglutide 3.0mg/d for the Treatment of Binge Eating Disorder Terminated NCT03279731 Phase 3 Liraglutide (Saxenda) 6Mg/Ml Inj Pen 3Ml;Placebo
27 A Dose Ranging Study of Modafinil for Methamphetamine Dependence Unknown status NCT00630097 Phase 2 modafinil
28 Distress Tolerance Treatment for Substance Users Unknown status NCT01741415 Phase 2
29 rTMS Over the Supplementary Motor Area for Treatment-resistant Obsessive-compulsive Disorder: a Multicenter, Double-blind, Controlled Trial. Unknown status NCT03211221 Phase 2
30 Memory Reconsolidation Blockade for Treating Drug Addiction: a Feasibility Study Completed NCT01634347 Phase 2 Propranolol and memory reactivation;Placebo and memory reactivation
31 D-Cycloserine and Cue Exposure in Cocaine-Dependent Individuals Completed NCT00780442 Phase 2 D-cycloserine;Placebo
32 Exploring Occupancy of Dopamine D3 Receptor by Buspirone in Humans Using PET Completed NCT01699828 Phase 1, Phase 2 Buspirone;Placebo
33 A Phase II, Randomized, Double-Blind Pilot Trial of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension) for the Treatment of Cocaine and Alcohol Dependence Completed NCT00777062 Phase 2 VIVITROL (Naltrexone extended-release injectable suspension);Placebo
34 A Pilot Trial of Atomoxetine to Enhance Motivational Interviewing Therapy for the Treatment of Cannabis Dependence Completed NCT00167297 Phase 2 Atomoxetine
35 A Double-Blind, Randomized, Placebo and Active-Controlled, Six-Period Crossover Study to Evaluate the Likeability, Safety, and Abuse Liability of NRP104 in Healthy Adult Volunteers With Histories of Stimulant Abuse Completed NCT00248092 Phase 1, Phase 2 NRP104
36 A Double-Blind Placebo- and Active-Controlled, Single-Dose Crossover PD and PK Study to Evaluate the Safety, Tolerability and Abuse Liability of IV Administered NRP104 25 mg and 50 mg in Adult Volunteers With Histories of Stimulant Abuse Completed NCT00247572 Phase 2 NRP104
37 Psychopharmacology of Novel Medications for Cocaine Dependence - Buspirone Completed NCT01267292 Phase 2 Buspirone;Placebo for Buspirone;Methylphenidate;Placebo for Methylphenidate
38 Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Treatment Completed NCT01410110 Phase 2
39 Clinical Trial of the Adrenergic Alpha-1 Antagonist Prazosin for Alcohol Dependence Completed NCT00762710 Phase 2 Prazosin medication;Placebo medication
40 Novel Therapeutics in PTSD: A Randomized Clinical Trial of Mifepristone Completed NCT01739335 Phase 2 Mifepristone Oral Tablet [Korlym];Placebo Oral Tablet
41 Deciphering the Role of Oxytocin in Motivation: an fMRI Study. Part II Recruiting NCT02652195 Phase 2 Placebo;Oxytocin
42 Neural Substrates of Emotion: Impact of Cocaine Dependence Recruiting NCT02682784 Phase 2 Oxytocin;Placebo
43 Placebo-Controlled Evaluation of the Efficacy of D-Cycloserine for Enhancing the Effects of CBT for Substance Use Terminated NCT00430573 Phase 2 D-cycloserine;Placebo
44 A Study to Investigate the Effects of GSK598809 in Newly Abstinent Nicotine-dependent Subjects. Withdrawn NCT00793468 Phase 2 GSK598809;Nicotine Replacement Transdermal Patch;Placebo
45 Oxytocin in Opiate Dependence: A Double-blind, Within-subjects, Placebo-controlled Pilot Study of the Effects of Intranasal Oxytocin on Emotional Processes and Stress Responses in Patients With Opiate Dependence Unknown status NCT02052258 Phase 1 Oxytocin
46 A Placebo Controlled, Single Blind, Randomised Study Investigating the Safety, Tolerability and Pharmacokinetics of Repeated Oral Doses of GSK598809 in Healthy Male and Female Volunteers for 28 Days. Completed NCT00437632 Phase 1 GSK598809;Placebo;Caffeine
47 A First Time in Human, Blinded, Randomised, Placebo-Controlled, Two-cohort Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Single Oral Escalating Doses of GSK618334 in Healthy Male Volunteers Completed NCT00513279 Phase 1 GSK618334;GSK618334 matching placebo tablets
48 A Randomized, Double-bind, Placebo Controlled, Two-way Cross-over Study to Assess the Effects of a Single Dose of GSK598809, a Selective DRD3 Antagonist, in Modulating Nicotine Reward Completed NCT00605241 Phase 1 GSK598809
49 A Placebo-controlled, Single Blind, Randomized Two Part Study Toinvestigate the Tolerability, Pharmacokinetics, and brainDopamine D3 Receptor Occupancy of Increasing Repeat Doses ofGSK618334 for up to 21 Days in Healthy Volunteers. Completed NCT01036061 Phase 1 GSK618334 Low Dose;GSK618334 PET subjects;GSK618334 Medium Dose;GSK618334 High Dose
50 A Placebo-controlled, Single-blind, Randomised, Human Volunteer Study Investigating the Tolerability and Pharmacokinetics of Escalating Single Oral Doses of GSK598809 in Smokers Completed NCT00437840 Phase 1 GSK598809;Placebo

Search NIH Clinical Center for Substance Dependence

Genetic Tests for Substance Dependence

Anatomical Context for Substance Dependence

MalaCards organs/tissues related to Substance Dependence:

40
Brain, Testes, Cortex, Eye, Prefrontal Cortex, Liver, Cingulate Cortex

Publications for Substance Dependence

Articles related to Substance Dependence:

(show top 50) (show all 2194)
# Title Authors PMID Year
1
Gender effect on association between DRD2 polymorphism and substance dependence in a Spanish sample. 61 54
19217722 2009
2
Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. 61 54
18828801 2008
3
CNR1 variation modulates risk for drug and alcohol dependence. 54 61
17509535 2007
4
Interaction between childhood trauma and serotonin transporter gene variation in suicide. 61 54
17356577 2007
5
Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. 54 61
17085484 2006
6
Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis. 54 61
16387451 2006
7
Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence. 61 54
16741937 2006
8
Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. 61 54
16476706 2006
9
A simple nonparametric multipoint procedure to test for linkage through mothers or fathers as well as imprinting effects in the presence of linkage. 54 61
16451620 2005
10
Combined effect of promoter polymorphisms in the dopamine D4 receptor and the serotonin transporter genes in heroin dependence. 54 61
16167465 2005
11
A genetic association study of the mu opioid receptor and severe opioid dependence. 54 61
12960749 2003
12
Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans. 61 54
12815747 2003
13
No association for D2 and D4 dopamine receptor polymorphisms and methamphetamine abuse in Chinese males. 54 61
11901357 2002
14
A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances. 61 54
11840318 2002
15
The D3 dopamine receptor and substance dependence. 54 61
11681590 2001
16
Family-based study of DRD2 alleles in alcohol and drug dependence. 61 54
11054774 2000
17
Antisociality, substance dependence, and the DRD5 gene: a preliminary study. 61 54
11054773 2000
18
Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. 61 54
10982041 2000
19
No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans. 54 61
10023512 1999
20
Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects. 61 54
9766763 1998
21
Population studies of polymorphisms at loci of neuropsychiatric interest (tryptophan hydroxylase (TPH), dopamine transporter protein (SLC6A3), D3 dopamine receptor (DRD3), apolipoprotein E (APOE), mu opioid receptor (OPRM1), and ciliary neurotrophic factor (CNTF)). 54 61
9790747 1998
22
Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1). 54 61
9756053 1998
23
An association between a microsatellite polymorphism at the DRD5 gene and the liability to substance abuse: pilot study. 54 61
9583233 1998
24
Mu opioid receptor gene variants: lack of association with alcohol dependence. 54 61
9399694 1997
25
Alcohol Use Disorder Among Adults Recovered From Substance Use Disorders. 61
32219914 2020
26
The role of impulsivity as predisposing behavioural trait in different aspects of alcohol self-administration in rats. 61
32371124 2020
27
Who worries about specific phobias? - A population-based study of risk factors. 61
32417598 2020
28
Opioid withdrawal and memory consolidation. 61
32294487 2020
29
GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task. 61
32299001 2020
30
Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses. 61
32538179 2020
31
Treatment Needs and Service Utilization in Older U.S. Adults Evidencing High-Risk Substance Use. 61
32515637 2020
32
Does Self-Change Occur Among Severely Dependent Substance Users? 61
32490757 2020
33
Positive and negative emotional expression measured from a single written essay about trauma predicts survival 17 years later in people living with HIV. 61
32559504 2020
34
Course, remission and recovery in patients with severe psychotic disorders with or without comorbid substance use disorders: Long-term outcome in evidence-based integrated care (ACCESS II study). 61
32507378 2020
35
Maternal behavioral health symptom profiles in early family life: complexity and context. 61
31297651 2020
36
Towards a brain-based predictome of mental illness. 61
32374075 2020
37
Treatment of Depression Following Traumatic Brain Injury Reduces Risk of Neuropsychiatric Outcomes. 61
32394786 2020
38
Measuring intangible cost-of-morbidity due to substance dependence: implications of using alternative preference-based instruments. 61
32419059 2020
39
Language ability and adult homelessness. 61
31925870 2020
40
Psychosocial impact of COVID-19. 61
32526627 2020
41
Food insecurity and substance use in people with HIV infection and substance use disorder. 61
32374225 2020
42
Mindfulness as a predictor of cognitive-behavioral therapy outcomes in inner-city adults with posttraumatic stress and substance dependence. 61
31927220 2020
43
[Narratives about the process of recovering from addiction: the perspective of family members attending care services]. 61
32574454 2020
44
Alcohol and Bone Turnover Markers among People Living with HIV and Substance Use Disorder. 61
32124466 2020
45
Aboriginal peoples in complete mental health: A nationally-representative Canadian portrait of resilience and flourishing. 61
31747867 2020
46
Designing residential aged care for people at risk of, or experiencing, homelessness: An exploratory Australian study. 61
32337822 2020
47
Structural connectivity in adolescent synthetic cannabinoid users with and without ADHD. 61
30617781 2020
48
The levels of anger and aggression in street children with substance dependence. 61
32314474 2020
49
Substance Dependence and Hepatitis among Tramadol Prescription Users: A Study of Former Adolescent Psychiatric Inpatients in Northern Finland. 61
31551050 2020
50
Personality disorders and social support in cannabis dependence: A comparison with alcohol dependence. 61
31957689 2020

Variations for Substance Dependence

Expression for Substance Dependence

Search GEO for disease gene expression data for Substance Dependence.

Pathways for Substance Dependence

Pathways related to Substance Dependence according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 POMC OPRM1 OPRK1 OPRD1 IL6 HTR1B
2
Show member pathways
13.05 POMC OPRM1 OPRK1 OPRD1 HTR1B DRD5
3
Show member pathways
12.88 SLC6A4 SLC6A3 MAOA CHRNB4 CHRNA5 CHRNA3
4
Show member pathways
12.68 DRD5 DRD4 DRD3 DRD2 BDNF
5
Show member pathways
12.43 SLC6A3 MAOA DRD5 DRD4 DRD3 DRD2
6 12.23 DRD5 DRD4 DRD3 DRD2
7 12.19 POMC HTR1B DRD5 DRD2 BDNF
9 12.01 SLC6A4 MAOA IL6 CHRNB4 BDNF
10
Show member pathways
11.88 SLC6A3 MAOA DRD2 BDNF
11 11.82 POMC OPRM1 OPRD1 MAOA IL6
12 11.78 DRD4 DRD3 CNR1
13
Show member pathways
11.76 HTR1B DRD5 DRD4 DRD3 DRD2
14
Show member pathways
11.68 CHRNB4 CHRNA5 CHRNA3
15
Show member pathways
11.66 DRD4 DRD3 DRD2 CHRNA5 CHRNA3
16
Show member pathways
11.63 MAOA ADH4 ADH1A
17
Show member pathways
11.33 SLC6A4 SLC6A3 MAOA
18 11.12 SLC6A4 MAOA HTR1B
19
Show member pathways
11.05 SLC6A4 SLC6A3 MAOA
20
Show member pathways
10.81 MAOA ADH4
21
Show member pathways
10.59 SLC6A4 SLC6A3 MAOA HTR1B DRD5 DRD4
22
Show member pathways
10.46 CHRNB4 CHRNA3

GO Terms for Substance Dependence

Cellular components related to Substance Dependence according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.35 SLC6A4 SLC6A3 OPRM1 OPRK1 OPRD1 MAOA
2 plasma membrane GO:0005886 10.31 SLC6A4 SLC6A3 OPRM1 OPRK1 OPRD1 HTR1B
3 synapse GO:0045202 10.02 SLC6A4 OPRK1 DRD5 DRD3 DRD2 CNR1
4 dendrite GO:0030425 9.95 OPRM1 OPRK1 HTR1B DRD4 DRD2 CHRNA3
5 axon GO:0030424 9.93 SLC6A3 OPRM1 DRD2 CNR1 BDNF
6 neuron projection GO:0043005 9.92 SLC6A4 SLC6A3 OPRM1 OPRK1 OPRD1 CHRNB4
7 membrane raft GO:0045121 9.89 SLC6A4 SLC6A3 OPRM1 OPRD1 CNR1
8 postsynaptic membrane GO:0045211 9.86 OPRD1 CHRNB4 CHRNA5 CHRNA3
9 integral component of plasma membrane GO:0005887 9.8 SLC6A4 SLC6A3 OPRM1 OPRK1 OPRD1 HTR1B
10 GABA-ergic synapse GO:0098982 9.74 DRD3 DRD2 CNR1
11 axon terminus GO:0043679 9.72 OPRK1 OPRD1 DRD2
12 integral component of postsynaptic membrane GO:0099055 9.65 SLC6A4 SLC6A3 OPRM1 OPRK1 DRD2
13 acetylcholine-gated channel complex GO:0005892 9.63 CHRNB4 CHRNA5 CHRNA3
14 spine apparatus GO:0097444 9.52 OPRM1 OPRD1
15 serotonergic synapse GO:0099154 9.51 SLC6A4 HTR1B
16 dopaminergic synapse GO:0098691 9.46 SLC6A3 DRD3 DRD2 CHRNA5
17 integral component of presynaptic membrane GO:0099056 9.23 SLC6A4 SLC6A3 OPRM1 OPRK1 OPRD1 HTR1B

Biological processes related to Substance Dependence according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.25 POMC OPRM1 OPRK1 OPRD1 HTR1B DRD5
2 cytokine-mediated signaling pathway GO:0019221 10.08 POMC OPRM1 OPRD1 MAOA IL6
3 response to drug GO:0042493 10.08 SLC6A4 SLC6A3 HTR1B DRD3 DRD2 BDNF
4 cell-cell signaling GO:0007267 10.04 POMC DRD5 DRD3 DRD2
5 chemical synaptic transmission GO:0007268 9.98 OPRK1 HTR1B DRD5 DRD4 CHRNB4 CHRNA5
6 neuropeptide signaling pathway GO:0007218 9.97 POMC OPRM1 OPRK1 OPRD1
7 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.95 DRD5 DRD3 DRD2 CNR1
8 cellular calcium ion homeostasis GO:0006874 9.93 DRD5 DRD4 DRD3
9 response to toxic substance GO:0009636 9.93 SLC6A4 DRD3 DRD2
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.92 OPRD1 IL6 BDNF
11 memory GO:0007613 9.92 SLC6A4 CNR1 BDNF
12 learning or memory GO:0007611 9.91 DRD3 CNR1 BDNF
13 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.91 OPRM1 OPRK1 OPRD1 HTR1B
14 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.9 OPRM1 OPRK1 OPRD1
15 sensory perception of pain GO:0019233 9.9 OPRM1 OPRK1 CNR1
16 regulation of synaptic vesicle exocytosis GO:2000300 9.9 HTR1B DRD2 CHRNA5
17 nervous system process GO:0050877 9.89 CHRNB4 CHRNA5 CHRNA3
18 social behavior GO:0035176 9.89 SLC6A4 DRD4 DRD3
19 excitatory postsynaptic potential GO:0060079 9.89 OPRM1 DRD2 CHRNB4 CHRNA5 CHRNA3
20 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.88 OPRM1 OPRD1 HTR1B DRD4 CNR1
21 feeding behavior GO:0007631 9.87 HTR1B DRD2 BDNF
22 neuromuscular synaptic transmission GO:0007274 9.87 CHRNB4 CHRNA5 CHRNA3
23 response to amphetamine GO:0001975 9.87 DRD5 DRD4 DRD3 DRD2
24 response to ethanol GO:0045471 9.87 SLC6A3 OPRM1 OPRK1 HTR1B DRD3 DRD2
25 negative regulation of blood pressure GO:0045776 9.86 DRD5 DRD3 DRD2 CNR1
26 regulation of dopamine secretion GO:0014059 9.85 HTR1B DRD3 DRD2
27 regulation of sensory perception of pain GO:0051930 9.85 OPRM1 OPRK1 OPRD1
28 synaptic transmission, cholinergic GO:0007271 9.84 CHRNB4 CHRNA5 CHRNA3
29 negative regulation of protein secretion GO:0050709 9.84 DRD4 DRD3 DRD2
30 dopamine receptor signaling pathway GO:0007212 9.84 DRD5 DRD4 DRD3 DRD2
31 arachidonic acid secretion GO:0050482 9.83 DRD4 DRD3 DRD2
32 eating behavior GO:0042755 9.83 OPRM1 OPRK1 OPRD1
33 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.83 DRD5 DRD3 DRD2
34 signal transduction GO:0007165 9.83 POMC OPRM1 OPRK1 OPRD1 IL6 HTR1B
35 negative regulation of voltage-gated calcium channel activity GO:1901386 9.82 DRD4 DRD3 DRD2
36 prepulse inhibition GO:0060134 9.81 SLC6A3 DRD3 DRD2
37 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.81 HTR1B DRD3 DRD2
38 behavioral response to cocaine GO:0048148 9.81 OPRK1 DRD4 DRD3 DRD2
39 dopamine metabolic process GO:0042417 9.8 DRD4 DRD3 DRD2
40 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.8 DRD5 DRD3 DRD2
41 G protein-coupled receptor internalization GO:0002031 9.79 HTR1B DRD3 DRD2
42 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.77 OPRM1 DRD5 DRD3
43 opioid receptor signaling pathway GO:0038003 9.77 OPRM1 OPRK1 OPRD1
44 response to morphine GO:0043278 9.77 OPRM1 OPRK1 DRD3 DRD2 CNR1
45 vasoconstriction GO:0042310 9.76 SLC6A4 HTR1B
46 regulation of synaptic transmission, GABAergic GO:0032228 9.76 DRD2 CNR1
47 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.76 DRD4 DRD3 DRD2
48 synaptic transmission, dopaminergic GO:0001963 9.76 DRD5 DRD4 DRD3 DRD2
49 behavior GO:0007610 9.75 OPRK1 HTR1B
50 neurotransmitter biosynthetic process GO:0042136 9.75 SLC6A4 SLC6A3

Molecular functions related to Substance Dependence according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.97 OPRM1 OPRK1 OPRD1 HTR1B DRD5 DRD4
2 peptide binding GO:0042277 9.76 OPRM1 OPRK1 OPRD1
3 extracellular ligand-gated ion channel activity GO:0005230 9.71 CHRNB4 CHRNA5 CHRNA3
4 ligand-gated ion channel activity GO:0015276 9.7 CHRNB4 CHRNA5 CHRNA3
5 neuropeptide binding GO:0042923 9.69 OPRM1 OPRK1 OPRD1
6 adrenergic receptor activity GO:0004935 9.67 DRD5 DRD3 DRD2
7 acetylcholine binding GO:0042166 9.65 CHRNB4 CHRNA5 CHRNA3
8 neurotransmitter receptor activity GO:0030594 9.65 HTR1B DRD4 CHRNB4 CHRNA5 CHRNA3
9 acetylcholine-gated cation-selective channel activity GO:0022848 9.63 CHRNB4 CHRNA5 CHRNA3
10 acetylcholine receptor activity GO:0015464 9.61 CHRNB4 CHRNA5 CHRNA3
11 serotonin binding GO:0051378 9.59 SLC6A4 HTR1B
12 alcohol dehydrogenase (NAD) activity GO:0004022 9.58 ADH4 ADH1A
13 opioid receptor activity GO:0004985 9.58 OPRM1 OPRK1 OPRD1
14 monoamine transmembrane transporter activity GO:0008504 9.57 SLC6A4 SLC6A3
15 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.56 ADH4 ADH1A
16 receptor serine/threonine kinase binding GO:0033612 9.55 OPRK1 OPRD1
17 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.54 DRD4 DRD3 DRD2
18 dopamine neurotransmitter receptor activity GO:0004952 9.46 DRD5 DRD4 DRD3 DRD2
19 dopamine binding GO:0035240 9.35 SLC6A3 DRD5 DRD4 DRD3 DRD2
20 drug binding GO:0008144 9.17 SLC6A3 HTR1B DRD4 DRD3 DRD2 CNR1

Sources for Substance Dependence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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