MCID: SBS005
MIFTS: 30

Substance-Induced Psychosis

Categories: Mental diseases

Aliases & Classifications for Substance-Induced Psychosis

MalaCards integrated aliases for Substance-Induced Psychosis:

Name: Substance-Induced Psychosis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:8646
ICD9CM 34 293.89
UMLS 70 C0154334

Summaries for Substance-Induced Psychosis

MalaCards based summary : Substance-Induced Psychosis is related to cannabis abuse and substance abuse. An important gene associated with Substance-Induced Psychosis is LHB (Luteinizing Hormone Subunit Beta), and among its related pathways/superpathways are Peptide ligand-binding receptors and Circadian entrainment. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 Substance-induced psychosis (commonly known as toxic psychosis or drug-induced psychosis) is a form of... more...

Related Diseases for Substance-Induced Psychosis

Diseases related to Substance-Induced Psychosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 cannabis abuse 30.2 HTR1A DRD2 COMT
2 substance abuse 29.9 SLC6A4 SLC6A3 HTR2A HTR1A DRD2 COMT
3 delusional disorder 29.9 SLC6A3 HTR2C HTR2A HTR1A DRD2
4 substance dependence 29.6 SLC6A4 SLC6A3 DTNBP1 DRD2 COMT
5 cocaine abuse 29.6 SLC6A4 SLC6A3 SLC18A2 DRD2
6 bipolar disorder 28.6 SLC6A4 SLC6A3 SLC18A2 HTR2C HTR2A HTR1A
7 psychotic disorder 28.3 TRIM32 SLC6A4 SLC6A3 SLC18A2 HTR2C HTR2A
8 schizophrenia 28.3 SLC6A4 SLC6A3 SLC18A2 HTR2C HTR2A HTR1A
9 polysubstance abuse 10.3 DRD2 COMT
10 traumatic brain injury 10.2 DRD2 COMT
11 brain injury 10.2 DRD2 COMT
12 opioid addiction 10.2 DRD2 COMT
13 inhibited female orgasm 10.2 HTR2A HTR1A
14 conversion disorder 10.2 HTR2A COMT
15 oculogyric crisis 10.2 HTR2A HTR1A
16 alcohol-induced mental disorder 10.2 SLC6A4 DRD2
17 paraphilia disorder 10.1 SLC6A4 DRD2
18 opioid abuse 10.1 SLC6A3 DRD2
19 tardive dyskinesia 10.1 HTR2A DRD2 COMT
20 neuroleptic malignant syndrome 10.1 HTR2A HTR1A DRD2
21 major affective disorder 8 10.1
22 major affective disorder 9 10.1
23 schizotypal personality disorder 10.1 HTR2A DTNBP1 COMT
24 retrograde amnesia 10.1 SLC6A4 HTR1A
25 hypoactive sexual desire disorder 10.1 HTR2C HTR2A HTR1A
26 acute stress disorder 10.1 SLC6A4 HTR1A
27 somatization disorder 10.1 SLC6A4 HTR1A COMT
28 migraine without aura 10.0 SLC6A4 HTR1A DRD2
29 hyperprolactinemia 10.0 HTR2C HTR2A DRD2
30 postpartum depression 10.0 SLC6A4 HTR1A COMT
31 striatonigral degeneration 10.0 SLC6A3 DRD2
32 opiate dependence 10.0 SLC6A4 SLC6A3 DRD2
33 glossitis 10.0 SLC6A4 COMT
34 drug dependence 10.0 SLC6A4 SLC6A3 DRD2
35 choreatic disease 10.0 SLC6A3 SLC18A2 DRD2
36 diamond-blackfan anemia 5 10.0 SLC6A4 HTR1A
37 metachromatic leukodystrophy 10.0 SLC6A4 SLC6A3 HTR1A
38 akinetopsia 10.0 TRIM32 HTR2A
39 bestiality 10.0 SLC6A3 HTR2A DRD2 COMT
40 atypical depressive disorder 10.0 SLC6A4 HTR2A HTR1A
41 adjustment disorder 10.0 SLC6A4 HTR2A HTR1A
42 melancholia 10.0 SLC6A4 HTR2A HTR1A
43 serotonin syndrome 10.0 SLC6A4 HTR2A HTR1A
44 obsessive-compulsive personality disorder 10.0 SLC6A4 HTR2A COMT
45 body dysmorphic disorder 10.0 SLC6A4 HTR2A
46 severe combined immunodeficiency 10.0
47 capgras syndrome 10.0
48 early-onset schizophrenia 10.0
49 kleptomania 9.9 SLC6A4 HTR1A DRD2 COMT
50 alcoholic psychosis 9.9 SLC6A4 SLC6A3 HTR2A

Graphical network of the top 20 diseases related to Substance-Induced Psychosis:



Diseases related to Substance-Induced Psychosis

Symptoms & Phenotypes for Substance-Induced Psychosis

GenomeRNAi Phenotypes related to Substance-Induced Psychosis according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.64 DRD2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.64 HTR2C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.64 FZD3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.64 FZD3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.64 FZD3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.64 FZD3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.64 DRD2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-187 9.64 SLC6A4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.64 DRD2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.64 SLC6A4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.64 DRD2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 FZD3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.64 DRD2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.64 SLC6A4
15 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.64 SLC6A4
16 Increased shRNA abundance (Z-score > 2) GR00366-A-71 9.64 SLC6A4
17 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.64 HTR2C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.64 HTR2C
19 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 FZD3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.64 DRD2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.64 SLC6A4

MGI Mouse Phenotypes related to Substance-Induced Psychosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 COMT DRD2 DTNBP1 FZD3 GRM2 HTR1A
2 homeostasis/metabolism MP:0005376 9.93 COMT DRD2 DTNBP1 FZD3 GRM2 HTR1A
3 muscle MP:0005369 9.56 DRD2 DTNBP1 HTR2A HTR2C SLC18A2 SLC6A3
4 nervous system MP:0003631 9.36 COMT DRD2 DTNBP1 FZD3 GRM2 HTR1A

Drugs & Therapeutics for Substance-Induced Psychosis

Search Clinical Trials , NIH Clinical Center for Substance-Induced Psychosis

Genetic Tests for Substance-Induced Psychosis

Anatomical Context for Substance-Induced Psychosis

MalaCards organs/tissues related to Substance-Induced Psychosis:

40
Eye

Publications for Substance-Induced Psychosis

Articles related to Substance-Induced Psychosis:

(show top 50) (show all 98)
# Title Authors PMID Year
1
Annual incidence of cannabis-induced psychosis, other substance-induced psychoses and dually diagnosed schizophrenia and cannabis use disorder in Denmark from 1994 to 2016. 61
31839011 2021
2
Differential effects of cannabis exposure during early versus later adolescence on the expression of psychosis in homeless and precariously housed adults. 61
32890696 2021
3
Herbal High: Substance-Induced Psychosis after Consumption of Seeds of the Hawaiian Baby Woodrose. 61
33661700 2021
4
Just the Facts: Substance induced psychosis. 61
33683604 2021
5
Self-enucleation of the right eye by a 38-year-old woman diagnosed with schizoaffective disorder: a case report. 61
33238922 2020
6
A comparative study of complete blood count inflammatory markers in substance-free acute psychotic disorder and substance-induced psychosis. 61
33254284 2020
7
Start low, go fast? Antipsychotic titration patterns at an inpatient psychiatric hospital. 61
33062553 2020
8
Organic vs Stimulant-Induced Psychosis in the Peripartum Period. 61
33145126 2020
9
Exploring indigenous ethnic inequities in first episode psychosis in New Zealand - A national cohort study. 61
32948382 2020
10
Infections as a Risk Factor for and Prognostic Factor After Substance-Induced Psychoses. 61
32046532 2020
11
Transition of Substance-Induced, Brief, and Atypical Psychoses to Schizophrenia: A Systematic Review and Meta-analysis. 61
31618428 2020
12
Methamphetamine Use and Antipsychotic-related Extrapyramidal Side-effects in Patients with Psychotic Disorders. 61
31984872 2020
13
Substance-induced Psychosis in Youth. 61
31708042 2020
14
The prevalence and clinical correlates of substance use disorders in patients with psychotic disorders from an Upper-Middle-Income Country. 61
32832129 2020
15
Diagnostic stability in substance-induced psychosis. 61
31982366 2020
16
Psychotic Disorders in Patients Who Use Synthetic Cannabinoids. 61
31821228 2019
17
Prediction of Onset of Substance-Induced Psychotic Disorder and Its Progression to Schizophrenia in a Swedish National Sample. 61
31055966 2019
18
Risk and associated factors for a future schizophrenia diagnosis after an index diagnosis of unspecified psychotic disorder: A population-based study. 61
31059990 2019
19
Corticosteroid-Induced Psychosis After a Single Transforaminal Epidural Steroid Injection. 61
31532936 2019
20
Anti-NMDA receptor encephalitis: a case study and illness overview. 61
31516531 2019
21
Capgras syndrome in substance-induced psychosis. 61
30542525 2018
22
Baby or bathwater? Referrals of "non-cases" in a targeted early identification intervention for psychosis. 61
29541798 2018
23
Substance-Induced Psychosis: An Indicator of Development of Primary Psychosis? 61
29606066 2018
24
Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis. 61
29179576 2018
25
Substance-induced psychotic symptoms in Borderline Personality Disorder among substance use disorder samples in Spain. 61
29227894 2018
26
Association of Environment With the Risk of Developing Psychotic Disorders in Rural Populations: Findings from the Social Epidemiology of Psychoses in East Anglia Study. 61
29188295 2018
27
Primary psychosis with comorbid drug abuse and drug-induced psychosis: Diagnostic and clinical evolution at follow up. 61
29061407 2017
28
Dextromethorphan in Cough Syrup: The Poor Man's Psychosis. 61
28936010 2017
29
Self-inflicted enucleations: Clinical features of seven cases. 61
28594303 2017
30
Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users. 61
26833821 2017
31
Structural and metabolic differentiation between bipolar disorder with psychosis and substance-induced psychosis: An integrated MRI/PET study. 61
28049086 2017
32
A Case of Attempted Bilateral Self-Enucleation in a Patient with Bipolar Disorder. 61
28748060 2017
33
Time trends in first admission rates for schizophrenia and other psychotic disorders in Taiwan, 1998-2007: a 10-year population-based cohort study. 61
28028581 2017
34
Standardised detoxification in cases of polydrug use. 61
27790891 2016
35
Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users. 61
27499362 2016
36
Psychosis induced by amphetamines. 61
27175554 2016
37
The profile of psychiatric symptoms exacerbated by methamphetamine use. 61
26874915 2016
38
Psychosis and Substance Use: Implications for Conditional Release Readiness Evaluations. 61
27021306 2016
39
Safety of Transcranial Direct Current Stimulation in Alcohol-Induced Psychotic Disorder with Comorbid Psoriasis. 61
27011409 2016
40
Changing trends in hospitalization rates associated with psychosis: Spain, 1980-2009. 61
26415493 2015
41
Long-term risk factors for substance-induced and primary psychosis after release from prison. A longitudinal study of substance users. 61
26359848 2015
42
Prodromal symptoms and remission following first episode psychosis. 61
26187148 2015
43
The Association of Salvia divinorum and Psychotic Disorders: A Review of the Literature and Case Series. 61
26317561 2015
44
The epidemiology and progression time from transient to permanent psychiatric disorders of substance-induced psychosis in Taiwan. 61
25841087 2015
45
The study of primary psychotic disorders with concurrent substance abuse in terms of their diagnostic stability. 61
26600573 2015
46
N,N-Dimethyltryptamine-Induced Psychosis. 61
26166234 2015
47
Psychopathology in Substance Use Disorder Patients with and without Substance-Induced Psychosis. 61
26417473 2015
48
Randomized controlled trial of aripiprazole versus risperidone for the treatment of amphetamine-induced psychosis. 61
24359506 2014
49
Gender differences in psychotic disorders with concurrent substance use. 61
25391275 2014
50
Comparison of history of adolescents with substance-induced psychosis, early onset schizophrenia and substance use disorders. 61
25520226 2014

Variations for Substance-Induced Psychosis

Expression for Substance-Induced Psychosis

Search GEO for disease gene expression data for Substance-Induced Psychosis.

Pathways for Substance-Induced Psychosis

Pathways related to Substance-Induced Psychosis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 LHB HTR2C HTR2A HTR1A GRM2 FZD3
2
Show member pathways
12.47 SLC6A3 SLC18A2 GRM2 DRD2 COMT
3 12.29 HTR1A GRM2 DTNBP1 COMT
4 11.92 SLC6A4 HTR2A HTR1A
5
Show member pathways
11.77 SLC6A4 SLC6A3 SLC18A2
6
Show member pathways
11.74 SLC6A3 SLC18A2 GRM2 DRD2
7 11.61 SLC6A4 SLC18A2 HTR2C HTR2A HTR1A
8
Show member pathways
11.6 HTR2C HTR2A HTR1A DRD2
9 11.55 HTR2C HTR2A DRD2
10
Show member pathways
10.91 SLC6A4 SLC6A3 COMT
11 10.83 HTR2C HTR2A
12 10.81 HTR2C DRD2
13 10.8 SLC6A4 SLC18A2 HTR2C HTR2A HTR1A
14
Show member pathways
10.46 SLC6A4 SLC6A3 SLC18A2 HTR1A DRD2 COMT

GO Terms for Substance-Induced Psychosis

Cellular components related to Substance-Induced Psychosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.32 SLC6A4 SLC6A3 SLC18A2 HTR2C HTR2A HTR1A
2 integral component of membrane GO:0016021 10.24 SLC6A4 SLC6A3 SLC18A2 HTR2C HTR2A HTR1A
3 plasma membrane GO:0005886 10.22 SLC6A4 SLC6A3 SLC18A2 HTR2C HTR2A HTR1A
4 integral component of plasma membrane GO:0005887 10.03 SLC6A4 SLC6A3 SLC18A2 HTR2C HTR2A HTR1A
5 synapse GO:0045202 9.86 SLC6A4 HTR2C HTR2A HTR1A GRM2 DTNBP1
6 neuron projection GO:0043005 9.83 SLC6A4 SLC6A3 GRM2 DTNBP1
7 dendritic spine GO:0043197 9.71 DTNBP1 DRD2 COMT
8 dendrite GO:0030425 9.7 HTR2C HTR2A HTR1A GRM2 FZD3 DRD2
9 integral component of presynaptic membrane GO:0099056 9.67 SLC6A4 SLC6A3 HTR2A DRD2
10 synaptic vesicle membrane GO:0030672 9.65 SLC18A2 DTNBP1 DRD2
11 dopaminergic synapse GO:0098691 9.5 SLC6A3 SLC18A2 DRD2
12 axon GO:0030424 9.5 SLC6A3 HTR2A GRM2 FZD3 DTNBP1 DRD2
13 G protein-coupled serotonin receptor complex GO:0098666 9.46 HTR2C HTR2A
14 integral component of postsynaptic membrane GO:0099055 9.02 SLC6A4 SLC6A3 HTR2A GRM2 DRD2

Biological processes related to Substance-Induced Psychosis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.21 LHB HTR2C HTR2A HTR1A GRM2 FZD3
2 G protein-coupled receptor signaling pathway GO:0007186 10.04 LHB HTR2C HTR2A HTR1A GRM2 FZD3
3 cellular calcium ion homeostasis GO:0006874 9.81 HTR2C HTR2A DRD2
4 response to toxic substance GO:0009636 9.79 SLC6A4 SLC18A2 DRD2
5 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.72 HTR2C HTR2A HTR1A
6 chemical synaptic transmission GO:0007268 9.72 SLC18A2 HTR2C HTR2A HTR1A GRM2
7 neurotransmitter transport GO:0006836 9.7 SLC6A4 SLC6A3 SLC18A2
8 regulation of synaptic vesicle exocytosis GO:2000300 9.69 HTR2A DTNBP1 DRD2
9 positive regulation of neuroblast proliferation GO:0002052 9.66 FZD3 DRD2
10 negative regulation of adenylate cyclase activity GO:0007194 9.65 GRM2 DRD2
11 temperature homeostasis GO:0001659 9.65 HTR2A DRD2
12 vasoconstriction GO:0042310 9.65 SLC6A4 HTR1A
13 release of sequestered calcium ion into cytosol GO:0051209 9.65 HTR2C HTR2A DRD2
14 response to iron ion GO:0010039 9.64 SLC6A3 DRD2
15 dopamine metabolic process GO:0042417 9.64 DRD2 COMT
16 behavioral response to cocaine GO:0048148 9.63 HTR2A DRD2
17 neurotransmitter biosynthetic process GO:0042136 9.62 SLC6A4 SLC6A3
18 prepulse inhibition GO:0060134 9.62 SLC6A3 DRD2
19 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.61 HTR2A DRD2
20 dopamine catabolic process GO:0042420 9.6 SLC6A3 COMT
21 regulation of dopamine metabolic process GO:0042053 9.59 SLC6A3 HTR1A
22 adenohypophysis development GO:0021984 9.58 SLC6A3 DRD2
23 hyaloid vascular plexus regression GO:1990384 9.58 SLC6A3 DRD2
24 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.58 HTR2C HTR2A HTR1A
25 serotonin uptake GO:0051610 9.57 SLC6A4 SLC18A2
26 serotonin receptor signaling pathway GO:0007210 9.56 HTR2A HTR1A
27 locomotory behavior GO:0007626 9.56 SLC6A3 SLC18A2 HTR2C DRD2
28 dopamine transport GO:0015872 9.54 SLC6A3 SLC18A2
29 regulation of dopamine secretion GO:0014059 9.54 HTR2A DTNBP1 DRD2
30 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.46 HTR2C HTR2A
31 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.43 HTR2C HTR2A
32 behavior GO:0007610 9.33 HTR2C HTR2A HTR1A
33 response to drug GO:0042493 9.17 SLC6A4 SLC6A3 HTR2C HTR2A FZD3 DRD2
34 monoamine transport GO:0015844 9.13 SLC6A4 SLC6A3 SLC18A2

Molecular functions related to Substance-Induced Psychosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.38 TRIM32 SLC6A4 SLC6A3 SLC18A2 LHB HTR2C
2 G protein-coupled receptor activity GO:0004930 9.88 HTR2C HTR2A HTR1A GRM2 FZD3 DRD2
3 neurotransmitter receptor activity GO:0030594 9.63 HTR2C HTR2A HTR1A
4 neurotransmitter transporter activity GO:0005326 9.49 SLC6A4 SLC6A3
5 dopamine binding GO:0035240 9.43 SLC6A3 DRD2
6 G protein-coupled serotonin receptor activity GO:0004993 9.43 HTR2C HTR2A HTR1A
7 serotonin:sodium symporter activity GO:0005335 9.37 SLC6A4 SLC18A2
8 Gq/11-coupled serotonin receptor activity GO:0001587 9.32 HTR2C HTR2A
9 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 9.16 HTR2C HTR2A
10 monoamine transmembrane transporter activity GO:0008504 9.13 SLC6A4 SLC6A3 SLC18A2
11 serotonin binding GO:0051378 8.92 SLC6A4 HTR2C HTR2A HTR1A

Sources for Substance-Induced Psychosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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