MCID: SBS005
MIFTS: 27

Substance-Induced Psychosis

Categories: Mental diseases

Aliases & Classifications for Substance-Induced Psychosis

MalaCards integrated aliases for Substance-Induced Psychosis:

Name: Substance-Induced Psychosis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:8646
ICD9CM 35 293.89
UMLS 73 C0154334

Summaries for Substance-Induced Psychosis

MalaCards based summary : Substance-Induced Psychosis is related to early-onset schizophrenia and schizophrenia. An important gene associated with Substance-Induced Psychosis is HTR1A (5-Hydroxytryptamine Receptor 1A), and among its related pathways/superpathways are Peptide ligand-binding receptors and Serotonergic synapse. The drugs Dopamine and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include brain and testes, and related phenotype is behavior/neurological.

Wikipedia : 76 Substance-induced psychosis (commonly known as toxic psychosis) is a form of substance use disorder... more...

Related Diseases for Substance-Induced Psychosis

Diseases related to Substance-Induced Psychosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 early-onset schizophrenia 29.7 DRD2 HTR2A
2 schizophrenia 29.7 DRD2 FZD3 HTR1A HTR2A
3 bipolar disorder 29.6 DRD2 HTR1A HTR2A
4 psychotic disorder 29.5 DRD2 HTR1A HTR2A
5 anxiety 10.1 HTR1A HTR2A
6 schizoid personality disorder 10.1 HTR1A HTR2A
7 hypoactive sexual desire disorder 10.1 HTR1A HTR2A
8 psychosexual disorder 10.1 HTR1A HTR2A
9 borderline personality disorder 10.0 HTR1A HTR2A
10 serotonin syndrome 10.0 HTR1A HTR2A
11 bipolar i disorder 10.0 HTR1A HTR2A
12 mental depression 10.0 HTR1A HTR2A
13 depression 10.0 HTR1A HTR2A
14 endogenous depression 10.0 HTR1A HTR2A
15 social phobia 10.0 DRD2 HTR1A
16 alexithymia 10.0 DRD2 HTR1A
17 neuroleptic malignant syndrome 10.0 DRD2 HTR1A
18 chronic fatigue syndrome 9.9 HTR1A HTR2A
19 migraine without aura 9.9 DRD2 HTR1A
20 capgras syndrome 9.9
21 tic disorder 9.9 DRD2 HTR2A
22 tardive dyskinesia 9.9 DRD2 HTR2A
23 alcoholic psychosis 9.9 DRD2 HTR2A
24 pathological gambling 9.9 DRD2 HTR2A
25 bruxism 9.9 DRD2 HTR2A
26 megacolon 9.8 DRD2 HTR2A
27 post-traumatic stress disorder 9.8 DRD2 HTR2A
28 schizoaffective disorder 9.8 DRD2 HTR2A
29 panic disorder 9.8 HTR1A HTR2A
30 alcohol abuse 9.8 DRD2 HTR2A
31 periodic limb movement disorder 9.8 DRD2 HTR1A HTR2A
32 drug-induced mental disorder 9.8 DRD2 HTR1A HTR2A
33 drug psychosis 9.8 DRD2 HTR1A HTR2A
34 personality disorder 9.8 DRD2 HTR1A HTR2A
35 generalized anxiety disorder 9.8 DRD2 HTR1A HTR2A
36 disease of mental health 9.8 DRD2 HTR1A HTR2A
37 mood disorder 9.8 DRD2 HTR1A HTR2A
38 obsessive-compulsive disorder 9.8 DRD2 HTR1A HTR2A
39 migraine with or without aura 1 9.8 DRD2 HTR1A HTR2A
40 alcohol dependence 9.7 DRD2 HTR1A HTR2A
41 major depressive disorder 9.7 DRD2 HTR1A HTR2A
42 attention deficit-hyperactivity disorder 9.7 DRD2 HTR1A HTR2A
43 tobacco addiction 9.7 DRD2 HTR2A
44 parkinson disease, late-onset 9.7 DRD2 HTR1A HTR2A
45 autism 9.6 DRD2 HTR1A HTR2A

Graphical network of the top 20 diseases related to Substance-Induced Psychosis:



Diseases related to Substance-Induced Psychosis

Symptoms & Phenotypes for Substance-Induced Psychosis

MGI Mouse Phenotypes related to Substance-Induced Psychosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.02 DRD2 FZD3 HTR1A HTR2A UGT8

Drugs & Therapeutics for Substance-Induced Psychosis

Drugs for Substance-Induced Psychosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
2
Aripiprazole Approved, Investigational Phase 2, Phase 3 129722-12-9 60795
3 Antipsychotic Agents Phase 2, Phase 3,Not Applicable
4 Serotonin 5-HT2 Receptor Antagonists Phase 2, Phase 3
5 Dopamine D2 Receptor Antagonists Phase 2, Phase 3
6 Paliperidone Palmitate Phase 2, Phase 3
7 Neurotransmitter Agents Phase 2, Phase 3
8 Psychotropic Drugs Phase 2, Phase 3
9 Dopamine Agents Phase 2, Phase 3
10 Tranquilizing Agents Phase 2, Phase 3
11 Central Nervous System Depressants Phase 2, Phase 3
12 Serotonin Antagonists Phase 2, Phase 3
13 Dopamine Antagonists Phase 2, Phase 3
14 Central Nervous System Stimulants Phase 2, Phase 3
15 Serotonin Agents Phase 2, Phase 3
16
Serotonin Investigational, Nutraceutical Phase 2, Phase 3 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Substance Misuse To Psychosis for Stimulants Not yet recruiting NCT03485417 Phase 2, Phase 3 Aripiprazole;Paliperidone
2 Prevention of Weight Gain in Early Psychoses Completed NCT01075295 Not Applicable
3 Lifestyle Intervention for Diabetes and Weight Management in Psychosis Completed NCT01828931 Not Applicable

Search NIH Clinical Center for Substance-Induced Psychosis

Genetic Tests for Substance-Induced Psychosis

Anatomical Context for Substance-Induced Psychosis

MalaCards organs/tissues related to Substance-Induced Psychosis:

41
Brain, Testes

Publications for Substance-Induced Psychosis

Articles related to Substance-Induced Psychosis:

(show all 24)
# Title Authors Year
1
Substance-Induced Psychosis: An Indicator of Development of Primary Psychosis? ( 29606066 )
2018
2
Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis. ( 29179576 )
2018
3
Capgras syndrome in substance-induced psychosis. ( 30542525 )
2018
4
Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users. ( 27499362 )
2016
5
Structural and metabolic differentiation between bipolar disorder with psychosis and substance-induced psychosis: An integrated MRI/PET study. ( 28049086 )
2016
6
Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users. ( 26833821 )
2016
7
The epidemiology and progression time from transient to permanent psychiatric disorders of substance-induced psychosis in Taiwan. ( 25841087 )
2015
8
Psychopathology in Substance Use Disorder Patients with and without Substance-Induced Psychosis. ( 26417473 )
2015
9
Comparison of history of adolescents with substance-induced psychosis, early onset schizophrenia and substance use disorders. ( 25520226 )
2014
10
Brain metabolism in substance-induced psychosis and schizophrenia: a preliminary PET study. ( 25471704 )
2014
11
Treatment of refractory substance-induced psychosis in adolescent males with a genetic predisposition to mental illness. ( 24762642 )
2014
12
Treated incidence and baseline characteristics of substance induced psychosis in a Norwegian catchment area. ( 24279887 )
2013
13
The risk of substance-induced psychosis converting to schizophrenia varies with substance used and patient age. ( 23708315 )
2013
14
Forensic considerations of substance-induced psychosis. ( 23771929 )
2013
15
A prospective 2-year study of emergency department patients with early-phase primary psychosis or substance-induced psychosis. ( 21454918 )
2011
16
A comparison of the symptoms and short-term clinical course in inpatients with substance-induced psychosis and primary psychosis. ( 20864293 )
2011
17
Substance-induced psychosis: a diagnostic conundrum. ( 18278990 )
2008
18
Developing and testing adaptive treatment strategies using substance-induced psychosis as an example. ( 18779776 )
2008
19
Remission one year after emergency admission is higher for substance-induced psychosis than primary psychosis. ( 17459972 )
2007
20
Stability of early-phase primary psychotic disorders with concurrent substance use and substance-induced psychosis. ( 17267925 )
2007
21
Substance-Induced Psychosis. ( 10085193 )
1998
22
Differential diagnosis of substance-induced psychosis and schizophrenia in patients with substance use disorders. ( 9165629 )
1997
23
Substance-induced psychosis. ( 8829765 )
1996
24
Substance-induced psychosis. ( 8733808 )
1996

Variations for Substance-Induced Psychosis

Expression for Substance-Induced Psychosis

Search GEO for disease gene expression data for Substance-Induced Psychosis.

Pathways for Substance-Induced Psychosis

GO Terms for Substance-Induced Psychosis

Cellular components related to Substance-Induced Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.33 DRD2 FZD3 HTR2A
2 integral component of presynaptic membrane GO:0099056 9.32 DRD2 HTR2A
3 lateral plasma membrane GO:0016328 9.26 DRD2 FZD3
4 integral component of postsynaptic membrane GO:0099055 8.96 DRD2 HTR2A
5 dendrite GO:0030425 8.92 DRD2 FZD3 HTR1A HTR2A

Biological processes related to Substance-Induced Psychosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.84 DRD2 FZD3 HTR1A HTR2A
2 G protein-coupled receptor signaling pathway GO:0007186 9.8 DRD2 FZD3 HTR1A HTR2A
3 response to drug GO:0042493 9.61 DRD2 FZD3 HTR2A
4 response to toxic substance GO:0009636 9.52 DRD2 GLYAT
5 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.51 HTR1A HTR2A
6 regulation of synaptic vesicle exocytosis GO:2000300 9.48 DRD2 HTR2A
7 release of sequestered calcium ion into cytosol GO:0051209 9.46 DRD2 HTR2A
8 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.4 HTR1A HTR2A
9 positive regulation of neuroblast proliferation GO:0002052 9.37 DRD2 FZD3
10 temperature homeostasis GO:0001659 9.32 DRD2 HTR2A
11 behavioral response to cocaine GO:0048148 9.26 DRD2 HTR2A
12 behavior GO:0007610 9.16 HTR1A HTR2A
13 negative regulation of synaptic transmission, glutamatergic GO:0051967 8.96 DRD2 HTR2A
14 serotonin receptor signaling pathway GO:0007210 8.62 HTR1A HTR2A

Molecular functions related to Substance-Induced Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.32 DRD2 HTR2A
2 neurotransmitter receptor activity GO:0030594 9.26 HTR1A HTR2A
3 G protein-coupled receptor activity GO:0004930 9.26 DRD2 FZD3 HTR1A HTR2A
4 G protein-coupled serotonin receptor activity GO:0004993 9.16 HTR1A HTR2A
5 serotonin binding GO:0051378 8.62 HTR1A HTR2A

Sources for Substance-Induced Psychosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....