MCID: SBS002
MIFTS: 27

Substernal Goiter

Categories: Endocrine diseases

Aliases & Classifications for Substernal Goiter

MalaCards integrated aliases for Substernal Goiter:

Name: Substernal Goiter 12 15 17 74
Retrosternal Thyroid Goiter 12
Goiter, Substernal 45

Classifications:



External Ids:

Disease Ontology 12 DOID:13200
MeSH 45 D006045
SNOMED-CT 69 66392007
UMLS 74 C0018024

Summaries for Substernal Goiter

MalaCards based summary : Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and arteries, anomalies of. An important gene associated with Substernal Goiter is NOTCH1 (Notch Receptor 1). Affiliated tissues include thyroid, bone and testes, and related phenotypes are craniofacial and skeleton

Related Diseases for Substernal Goiter

Graphical network of the top 20 diseases related to Substernal Goiter:



Diseases related to Substernal Goiter

Symptoms & Phenotypes for Substernal Goiter

MGI Mouse Phenotypes related to Substernal Goiter:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.13 F7 NOTCH1 PTH
2 skeleton MP:0005390 8.92 F7 NOTCH1 PTH TG

Drugs & Therapeutics for Substernal Goiter

Search Clinical Trials , NIH Clinical Center for Substernal Goiter

Cochrane evidence based reviews: goiter, substernal

Genetic Tests for Substernal Goiter

Anatomical Context for Substernal Goiter

MalaCards organs/tissues related to Substernal Goiter:

42
Thyroid, Bone, Testes, Trachea

Publications for Substernal Goiter

Articles related to Substernal Goiter:

(show top 50) (show all 86)
# Title Authors Year
1
Ultrasound-Guided Percutaneous Microwave Ablation for Substernal Goiter: Initial Experience. ( 30900322 )
2019
2
Substernal goiter presenting as acute respiratory failure. ( 29622368 )
2018
3
Substernal Goiter: Correlation between Grade and Surgical Approach. ( 29580356 )
2018
4
Substernal goiter: Treatment and challenges. Twenty-two years of experience in diagnosis and management of substernal goiters. ( 30055961 )
2018
5
A Large Substernal Goiter that Extended to Both Sides of the Thorax. ( 30533243 )
2018
6
Morbidity of total thyroidectomy for substernal goiter: A series of 70 patients. ( 28602544 )
2017
7
Patient-tailored management of an asymptomatic massive substernal goiter presenting as brachiocephalic vein occlusion. Report of a case and review of sternotomy indications. ( 28095343 )
2017
8
Substernal goiter and laryngopharyngeal reflux. ( 28658344 )
2017
9
Chylothorax Associated with Substernal Goiter in Graves' Disease Treated with Radioactive Iodine. ( 28835765 )
2017
10
Surgical treatment of substernal goiter: An analysis of 44 cases. ( 26995097 )
2016
11
Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. ( 27005286 )
2016
12
Preoperative risk factors in total thyroidectomy of substernal goiter. ( 27932888 )
2016
13
Erratum to: Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. ( 27387178 )
2016
14
Substernal goiter: Experience with 50A cases. ( 26520480 )
2015
15
Harmonic focus in thyroidectomy for substernal goiter. ( 25752670 )
2015
16
Sternotomy for substernal goiter: retrospective study of 52 operations. ( 25691265 )
2015
17
Substernal goiter: when is a sternotomy required? ( 25976851 )
2015
18
Recurrent laryngeal nerve palsy and substernal goiter. An Italian multicenter study. ( 24880605 )
2014
19
Substernal Goiter: When is a Sternotomy Required? ( 25058777 )
2014
20
Transient palsy of recurrent laryngeal nerve postresection of giant substernal goiter. ( 25798363 )
2014
21
eComment. Substernal goiter. Beware of the thyroidea ima artery. ( 24944323 )
2014
22
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. ( 24228633 )
2013
23
Obstructive sleep apnea caused by substernal goiter presenting as nonarteritic ischemic optic neuropathy. ( 22899396 )
2013
24
Chylothorax associated with substernal goiter treated with transcervical thyroidectomy. ( 21476890 )
2011
25
CT cross-sectional imaging classification system for substernal goiter based on risk factors for an extracervical surgical approach. ( 20737483 )
2011
26
Single-stage operation for giant substernal goiter with severe coronary artery disease. ( 21881378 )
2011
27
Clinical images. Solitary fibrous tumor of the perithyroidal soft tissue mimicking substernal goiter. ( 20609717 )
2010
28
Morbidity and mortality of thyroidectomy for substernal goiter. ( 19827121 )
2010
29
Substernal goiter: what is in a definition? ( 20109623 )
2010
30
Management of the substernal goiter: a team approach. ( 20830956 )
2010
31
Superior vena cava syndrome and substernal goiter. ( 20151836 )
2010
32
Incidental detection of internal jugular vein thrombosis secondary to undiagnosed benign substernal goiter. ( 20814560 )
2010
33
Image in endocrinology. Pemberton's sign in patient with substernal goiter. ( 20823469 )
2010
34
A critical analysis of 33 patients with substernal goiter surgically treated by neck incision. ( 19575100 )
2009
35
Diagnosis and management of substernal goiter at the University of Crete. ( 18239864 )
2008
36
Surgical treatment of substernal goiter: an analysis of 59 patients. ( 18516529 )
2008
37
Evidence-based surgical management of substernal goiter. ( 18266028 )
2008
38
Extended tracheal stenosis secondary to a massive substernal goiter. ( 17956165 )
2007
39
Thyroidectomy for substernal goiter via a mediastinoscopic approach. ( 16999061 )
2006
40
Retrosternal thyroid goiter: 15 years experience. ( 16544733 )
2006
41
Management of an ascending aortic aneurysm with coronary artery disease and tracheal compression from a substernal goiter. ( 15725145 )
2005
42
VATS with a supraclavicular window for huge substernal goiter: an alternative technique for preventing recurrent laryngeal nerve injury. ( 16037869 )
2005
43
Substernal goiter: an unusual cause of respiratory failure after coronary artery bypass grafting. ( 16107122 )
2005
44
Predictors of airway complications after thyroidectomy for substernal goiter. ( 15197094 )
2004
45
Giant substernal goiter with chylothorax. ( 12878569 )
2003
46
Thyroid abscess associated with a substernal goiter. Case report. ( 12813398 )
2003
47
Novel technique for control of mediastinal bleeding during thyroidectomy for substernal goiter. ( 12742217 )
2003
48
Visual vignette. Mediastinal mass due to substernal goiter. ( 12134778 )
2002
49
Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. ( 11391314 )
2001
50
Operative management of substernal goiter: analysis of 52 patients. ( 12056465 )
2001

Variations for Substernal Goiter

Expression for Substernal Goiter

Search GEO for disease gene expression data for Substernal Goiter.

Pathways for Substernal Goiter

GO Terms for Substernal Goiter

Cellular components related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 8.92 F7 NOTCH1 PTH TG

Biological processes related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.32 F7 NOTCH1
2 regulation of gene expression GO:0010468 9.26 NOTCH1 PTH
3 response to nutrient levels GO:0031667 9.16 F7 PTH
4 animal organ regeneration GO:0031100 8.96 F7 NOTCH1
5 homeostasis of number of cells within a tissue GO:0048873 8.62 NOTCH1 PTH

Molecular functions related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 PTH TG

Sources for Substernal Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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