MCID: SBS002
MIFTS: 26

Substernal Goiter

Categories: Endocrine diseases

Aliases & Classifications for Substernal Goiter

MalaCards integrated aliases for Substernal Goiter:

Name: Substernal Goiter 12 15 73
Retrosternal Thyroid Goiter 12
Goiter, Substernal 44

Classifications:



External Ids:

Disease Ontology 12 DOID:13200
MeSH 44 D006045
SNOMED-CT 68 66392007
UMLS 73 C0018024

Summaries for Substernal Goiter

MalaCards based summary : Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and arteries, anomalies of. An important gene associated with Substernal Goiter is NOTCH1 (Notch 1), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include thyroid, bone and testes.

Related Diseases for Substernal Goiter

Graphical network of the top 20 diseases related to Substernal Goiter:



Diseases related to Substernal Goiter

Symptoms & Phenotypes for Substernal Goiter

Drugs & Therapeutics for Substernal Goiter

Search Clinical Trials , NIH Clinical Center for Substernal Goiter

Cochrane evidence based reviews: goiter, substernal

Genetic Tests for Substernal Goiter

Anatomical Context for Substernal Goiter

MalaCards organs/tissues related to Substernal Goiter:

41
Thyroid, Bone, Testes, Trachea

Publications for Substernal Goiter

Articles related to Substernal Goiter:

(show top 50) (show all 85)
# Title Authors Year
1
Substernal goiter presenting as acute respiratory failure. ( 29622368 )
2018
2
Substernal Goiter: Correlation between Grade and Surgical Approach. ( 29580356 )
2018
3
Substernal goiter: Treatment and challenges. Twenty-two years of experience in diagnosis and management of substernal goiters. ( 30055961 )
2018
4
A Large Substernal Goiter that Extended to Both Sides of the Thorax. ( 30533243 )
2018
5
Morbidity of total thyroidectomy for substernal goiter: A series of 70 patients. ( 28602544 )
2017
6
Patient-tailored management of an asymptomatic massive substernal goiter presenting as brachiocephalic vein occlusion. Report of a case and review of sternotomy indications. ( 28095343 )
2017
7
Substernal goiter and laryngopharyngeal reflux. ( 28658344 )
2017
8
Chylothorax Associated with Substernal Goiter in Graves' Disease Treated with Radioactive Iodine. ( 28835765 )
2017
9
Surgical treatment of substernal goiter: An analysis of 44 cases. ( 26995097 )
2016
10
Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. ( 27005286 )
2016
11
Preoperative risk factors in total thyroidectomy of substernal goiter. ( 27932888 )
2016
12
Erratum to: Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. ( 27387178 )
2016
13
Substernal goiter: Experience with 50A cases. ( 26520480 )
2015
14
Harmonic focus in thyroidectomy for substernal goiter. ( 25752670 )
2015
15
Sternotomy for substernal goiter: retrospective study of 52 operations. ( 25691265 )
2015
16
Substernal goiter: when is a sternotomy required? ( 25976851 )
2015
17
Recurrent laryngeal nerve palsy and substernal goiter. An Italian multicenter study. ( 24880605 )
2014
18
Substernal Goiter: When is a Sternotomy Required? ( 25058777 )
2014
19
Transient palsy of recurrent laryngeal nerve postresection of giant substernal goiter. ( 25798363 )
2014
20
eComment. Substernal goiter. Beware of the thyroidea ima artery. ( 24944323 )
2014
21
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. ( 24228633 )
2013
22
Obstructive sleep apnea caused by substernal goiter presenting as nonarteritic ischemic optic neuropathy. ( 22899396 )
2013
23
Chylothorax associated with substernal goiter treated with transcervical thyroidectomy. ( 21476890 )
2011
24
CT cross-sectional imaging classification system for substernal goiter based on risk factors for an extracervical surgical approach. ( 20737483 )
2011
25
Single-stage operation for giant substernal goiter with severe coronary artery disease. ( 21881378 )
2011
26
Clinical images. Solitary fibrous tumor of the perithyroidal soft tissue mimicking substernal goiter. ( 20609717 )
2010
27
Morbidity and mortality of thyroidectomy for substernal goiter. ( 19827121 )
2010
28
Substernal goiter: what is in a definition? ( 20109623 )
2010
29
Management of the substernal goiter: a team approach. ( 20830956 )
2010
30
Superior vena cava syndrome and substernal goiter. ( 20151836 )
2010
31
Incidental detection of internal jugular vein thrombosis secondary to undiagnosed benign substernal goiter. ( 20814560 )
2010
32
Image in endocrinology. Pemberton's sign in patient with substernal goiter. ( 20823469 )
2010
33
A critical analysis of 33 patients with substernal goiter surgically treated by neck incision. ( 19575100 )
2009
34
Diagnosis and management of substernal goiter at the University of Crete. ( 18239864 )
2008
35
Surgical treatment of substernal goiter: an analysis of 59 patients. ( 18516529 )
2008
36
Evidence-based surgical management of substernal goiter. ( 18266028 )
2008
37
Extended tracheal stenosis secondary to a massive substernal goiter. ( 17956165 )
2007
38
Thyroidectomy for substernal goiter via a mediastinoscopic approach. ( 16999061 )
2006
39
Retrosternal thyroid goiter: 15 years experience. ( 16544733 )
2006
40
Management of an ascending aortic aneurysm with coronary artery disease and tracheal compression from a substernal goiter. ( 15725145 )
2005
41
VATS with a supraclavicular window for huge substernal goiter: an alternative technique for preventing recurrent laryngeal nerve injury. ( 16037869 )
2005
42
Substernal goiter: an unusual cause of respiratory failure after coronary artery bypass grafting. ( 16107122 )
2005
43
Predictors of airway complications after thyroidectomy for substernal goiter. ( 15197094 )
2004
44
Giant substernal goiter with chylothorax. ( 12878569 )
2003
45
Thyroid abscess associated with a substernal goiter. Case report. ( 12813398 )
2003
46
Novel technique for control of mediastinal bleeding during thyroidectomy for substernal goiter. ( 12742217 )
2003
47
Visual vignette. Mediastinal mass due to substernal goiter. ( 12134778 )
2002
48
Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. ( 11391314 )
2001
49
Operative management of substernal goiter: analysis of 52 patients. ( 12056465 )
2001
50
Surgical treatment of substernal goiter. ( 11324994 )
2000

Variations for Substernal Goiter

Expression for Substernal Goiter

Search GEO for disease gene expression data for Substernal Goiter.

Pathways for Substernal Goiter

Pathways related to Substernal Goiter according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.69 CD79A NOTCH1

GO Terms for Substernal Goiter

Biological processes related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 9.16 F7 PTH
2 animal organ regeneration GO:0031100 8.96 F7 NOTCH1
3 homeostasis of number of cells within a tissue GO:0048873 8.62 NOTCH1 PTH

Molecular functions related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 PTH TG

Sources for Substernal Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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