MCID: SBS002
MIFTS: 26

Substernal Goiter

Categories: Endocrine diseases

Aliases & Classifications for Substernal Goiter

MalaCards integrated aliases for Substernal Goiter:

Name: Substernal Goiter 12 15 73
Retrosternal Thyroid Goiter 12
Goiter, Substernal 44

Classifications:



External Ids:

Disease Ontology 12 DOID:13200
MeSH 44 D006045
SNOMED-CT 68 190234009 66392007
UMLS 73 C0018024

Summaries for Substernal Goiter

MalaCards based summary : Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and subclavian steal syndrome. An important gene associated with Substernal Goiter is NOTCH1 (Notch 1), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include thyroid, trachea and testes.

Related Diseases for Substernal Goiter

Diseases related to Substernal Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 goiter 10.9
2 subclavian steal syndrome 10.3 KANTR NOTCH1
3 petroclival meningioma 10.3 KANTR NOTCH1
4 brachial plexus neuritis 10.2 KANTR NOTCH1
5 sciatic neuropathy 10.2 KANTR NOTCH1
6 optic disk drusen 10.2 KANTR NOTCH1
7 anterior cranial fossa meningioma 10.2 F7 KANTR
8 visual agnosia 10.2 F7 KANTR
9 laryngitis 10.2
10 mediastinitis 10.2
11 dystonia 1, torsion, autosomal dominant 10.2 KANTR NOTCH1
12 radiation cystitis 10.1 F7 KANTR
13 carotid artery dissection 10.1 KANTR NOTCH1
14 arteries, anomalies of 10.1
15 coronary artery anomaly 10.1
16 respiratory failure 10.1
17 thyroiditis 10.1
18 postsurgical hypothyroidism 10.0 PTH TG
19 hypertropia 10.0 KANTR TG
20 water-clear cell adenoma 10.0 PTH TG
21 clear cell adenoma 10.0 PTH TG
22 apnea, obstructive sleep 9.9
23 hemangiopericytoma, malignant 9.9
24 ischemic optic neuropathy 9.9
25 pulmonary emphysema 9.9
26 sleep apnea 9.9
27 thrombosis 9.9
28 mucositis 9.9
29 esophagitis 9.9
30 graves' disease 9.9
31 optic nerve disease 9.9
32 tracheal stenosis 9.9
33 aortic aneurysm 9.9
34 neuropathy 9.9
35 aneurysm 9.9
36 syncope 9.9
37 endocrine organ benign neoplasm 9.8 PTH TG
38 salpingitis isthmica nodosa 9.8 CD79A KANTR
39 cicatricial entropion 9.8 CD79A KANTR
40 thyroid gland disease 9.8 PTH TG
41 cerebral arteritis 9.8 CD79A KANTR
42 geniculate herpes zoster 9.8 CD79A KANTR
43 tabes dorsalis 9.7 CD79A KANTR
44 pulmonary hemosiderosis 9.7 CD79A F7
45 amyloid tumor 9.7 CD79A TG
46 scleredema adultorum 9.7 CD79A PTH
47 chronic salpingitis 9.6 CD79A KANTR
48 hypersensitivity reaction disease 9.5 CD79A TG
49 thyroid crisis 9.4 KANTR PTH TG
50 end stage renal failure 9.4 CD79A PTH

Graphical network of the top 20 diseases related to Substernal Goiter:



Diseases related to Substernal Goiter

Symptoms & Phenotypes for Substernal Goiter

Drugs & Therapeutics for Substernal Goiter

Search Clinical Trials , NIH Clinical Center for Substernal Goiter

Cochrane evidence based reviews: goiter, substernal

Genetic Tests for Substernal Goiter

Anatomical Context for Substernal Goiter

MalaCards organs/tissues related to Substernal Goiter:

41
Thyroid, Trachea, Testes, Bone

Publications for Substernal Goiter

Articles related to Substernal Goiter:

(show top 50) (show all 81)
# Title Authors Year
1
Substernal goiter presenting as acute respiratory failure. ( 29622368 )
2018
2
Substernal Goiter: Correlation between Grade and Surgical Approach. ( 29580356 )
2018
3
Morbidity of total thyroidectomy for substernal goiter: A series of 70 patients. ( 28602544 )
2017
4
Patient-tailored management of an asymptomatic massive substernal goiter presenting as brachiocephalic vein occlusion. Report of a case and review of sternotomy indications. ( 28095343 )
2017
5
Substernal goiter and laryngopharyngeal reflux. ( 28658344 )
2017
6
Chylothorax Associated with Substernal Goiter in Graves' Disease Treated with Radioactive Iodine. ( 28835765 )
2017
7
Surgical treatment of substernal goiter: An analysis of 44 cases. ( 26995097 )
2016
8
Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. ( 27005286 )
2016
9
Preoperative risk factors in total thyroidectomy of substernal goiter. ( 27932888 )
2016
10
Substernal goiter: Experience with 50A cases. ( 26520480 )
2015
11
Harmonic focus in thyroidectomy for substernal goiter. ( 25752670 )
2015
12
Sternotomy for substernal goiter: retrospective study of 52 operations. ( 25691265 )
2015
13
Substernal goiter: when is a sternotomy required? ( 25976851 )
2015
14
Recurrent laryngeal nerve palsy and substernal goiter. An Italian multicenter study. ( 24880605 )
2014
15
Substernal Goiter: When is a Sternotomy Required? ( 25058777 )
2014
16
Transient palsy of recurrent laryngeal nerve postresection of giant substernal goiter. ( 25798363 )
2014
17
eComment. Substernal goiter. Beware of the thyroidea ima artery. ( 24944323 )
2014
18
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. ( 24228633 )
2013
19
Obstructive sleep apnea caused by substernal goiter presenting as nonarteritic ischemic optic neuropathy. ( 22899396 )
2013
20
Chylothorax associated with substernal goiter treated with transcervical thyroidectomy. ( 21476890 )
2011
21
CT cross-sectional imaging classification system for substernal goiter based on risk factors for an extracervical surgical approach. ( 20737483 )
2011
22
Single-stage operation for giant substernal goiter with severe coronary artery disease. ( 21881378 )
2011
23
Clinical images. Solitary fibrous tumor of the perithyroidal soft tissue mimicking substernal goiter. ( 20609717 )
2010
24
Morbidity and mortality of thyroidectomy for substernal goiter. ( 19827121 )
2010
25
Substernal goiter: what is in a definition? ( 20109623 )
2010
26
Management of the substernal goiter: a team approach. ( 20830956 )
2010
27
Superior vena cava syndrome and substernal goiter. ( 20151836 )
2010
28
Incidental detection of internal jugular vein thrombosis secondary to undiagnosed benign substernal goiter. ( 20814560 )
2010
29
Image in endocrinology. Pemberton's sign in patient with substernal goiter. ( 20823469 )
2010
30
A critical analysis of 33 patients with substernal goiter surgically treated by neck incision. ( 19575100 )
2009
31
Diagnosis and management of substernal goiter at the University of Crete. ( 18239864 )
2008
32
Surgical treatment of substernal goiter: an analysis of 59 patients. ( 18516529 )
2008
33
Evidence-based surgical management of substernal goiter. ( 18266028 )
2008
34
Extended tracheal stenosis secondary to a massive substernal goiter. ( 17956165 )
2007
35
Thyroidectomy for substernal goiter via a mediastinoscopic approach. ( 16999061 )
2006
36
Management of an ascending aortic aneurysm with coronary artery disease and tracheal compression from a substernal goiter. ( 15725145 )
2005
37
VATS with a supraclavicular window for huge substernal goiter: an alternative technique for preventing recurrent laryngeal nerve injury. ( 16037869 )
2005
38
Substernal goiter: an unusual cause of respiratory failure after coronary artery bypass grafting. ( 16107122 )
2005
39
Predictors of airway complications after thyroidectomy for substernal goiter. ( 15197094 )
2004
40
Giant substernal goiter with chylothorax. ( 12878569 )
2003
41
Thyroid abscess associated with a substernal goiter. Case report. ( 12813398 )
2003
42
Novel technique for control of mediastinal bleeding during thyroidectomy for substernal goiter. ( 12742217 )
2003
43
Visual vignette. Mediastinal mass due to substernal goiter. ( 12134778 )
2002
44
Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. ( 11391314 )
2001
45
Operative management of substernal goiter: analysis of 52 patients. ( 12056465 )
2001
46
Surgical treatment of substernal goiter. ( 11324994 )
2000
47
Calcified substernal goiter seen on bone scan. ( 10983765 )
2000
48
Surgical management of substernal goiter. ( 11155771 )
2000
49
Bilateral recurrent nerve paralysis associated with multinodular substernal goiter: a case report. ( 10231217 )
1999
50
Substernal goiter: clinical experience of 72 cases. ( 10335714 )
1999

Variations for Substernal Goiter

Expression for Substernal Goiter

Search GEO for disease gene expression data for Substernal Goiter.

Pathways for Substernal Goiter

Pathways related to Substernal Goiter according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.69 CD79A NOTCH1

GO Terms for Substernal Goiter

Biological processes related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 8.96 F7 PTH
2 animal organ regeneration GO:0031100 8.62 F7 NOTCH1

Molecular functions related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 PTH TG

Sources for Substernal Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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