MCID: SBS002
MIFTS: 26

Substernal Goiter

Categories: Endocrine diseases

Aliases & Classifications for Substernal Goiter

MalaCards integrated aliases for Substernal Goiter:

Name: Substernal Goiter 12 15 17 71
Retrosternal Thyroid Goiter 12
Retrosternal Thyroid Goitre 12
Goiter, Substernal 44
Substernal Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13200
MeSH 44 D006045
SNOMED-CT 67 66392007
UMLS 71 C0018024

Summaries for Substernal Goiter

MalaCards based summary : Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and papillary carcinoma. An important gene associated with Substernal Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Transcription_Role of VDR in regulation of genes involved in osteoporosis. Affiliated tissues include thyroid, lymph node and endothelial.

Related Diseases for Substernal Goiter

Diseases related to Substernal Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 goiter 31.8 TG CALCA
2 papillary carcinoma 30.5 TG CALCA
3 multinodular goiter 30.4 TG PTH CALCA
4 thyroid carcinoma 30.4 TG CALCA
5 thyroiditis 30.4 TG CALCA
6 nodular goiter 30.4 TG CALCA
7 follicular adenoma 30.4 TG CALCA
8 hyperthyroidism 30.3 TG PTH CALCA
9 graves disease 1 30.2 TG PTH CALCA
10 hypoparathyroidism 30.1 TBCE PTH GCM2 CALCA
11 thyroid gland disease 29.8 TG PTH CALCA
12 hyperparathyroidism 29.7 PTH GCM2 CALCA
13 primary hyperparathyroidism 29.7 PTH GCM2 CALCA
14 parathyroid carcinoma 29.4 TG PTH GCM2 CALCA
15 dysphagia 10.4
16 respiratory failure 10.2
17 tracheal stenosis 10.2
18 arteries, anomalies of 10.2
19 lipoprotein quantitative trait locus 10.2
20 tracheomalacia 10.2
21 hypothyroidism 10.2
22 aortic aneurysm 10.2
23 clear cell adenoma 10.1 TG PTH
24 postsurgical hypothyroidism 10.1 TG PTH
25 tall cell variant papillary carcinoma 10.1 TG PTH
26 thyroid gland mucoepidermoid carcinoma 10.1 TG CALCA
27 mucoepidermoid carcinoma 10.1 TG CALCA
28 anal spasm 10.1 TG PTH
29 spindle epithelial tumor with thymus-like differentiation tumor 10.1 TG CALCA
30 endemic goiter 10.1 TG PTH
31 isthmus cancer 10.1 TG CALCA
32 atypical follicular adenoma 10.1 TG CALCA
33 thyroid sarcoma 10.1 TG CALCA
34 plummer's disease 10.1 TG PTH
35 carotid body cancer 10.1 TG CALCA
36 nonencapsulated sclerosing carcinoma 10.1 TG CALCA
37 acute thyroiditis 10.1 TG CALCA
38 fetal adenoma 10.1 TG CALCA
39 epithelial malignant thymoma 10.1 TG CALCA
40 hypothyroidism, congenital, nongoitrous, 1 10.1 TG PTH
41 thyroid angiosarcoma 10.1 TG CALCA
42 malignant ovarian brenner tumor 10.1 PTH CALCA
43 nasal cavity olfactory neuroblastoma 10.1 TG CALCA
44 uterus leiomyosarcoma 10.1 TG CALCA
45 papillary thyroid microcarcinoma 10.1 TG CALCA
46 chief cell adenoma 10.1 PTH GCM2
47 gorham's disease 10.1 PTH CALCA
48 hypervitaminosis d 10.1 PTH CALCA
49 autoimmune disease of endocrine system 10.1 TG PTH
50 hypercalcemia, infantile, 1 10.1 PTH CALCA

Graphical network of the top 20 diseases related to Substernal Goiter:



Diseases related to Substernal Goiter

Symptoms & Phenotypes for Substernal Goiter

Drugs & Therapeutics for Substernal Goiter

Search Clinical Trials , NIH Clinical Center for Substernal Goiter

Cochrane evidence based reviews: goiter, substernal

Genetic Tests for Substernal Goiter

Anatomical Context for Substernal Goiter

MalaCards organs/tissues related to Substernal Goiter:

40
Thyroid, Lymph Node, Endothelial, Trachea

Publications for Substernal Goiter

Articles related to Substernal Goiter:

(show top 50) (show all 230)
# Title Authors PMID Year
1
Sutureless Total Thyroidectomy for Substernal Goiter: Amending Versus Unnecessary. 61
33489637 2021
2
To explore the risk factors and preventive measures affecting the treatment of retrosternal goiter: An observational study. 61
33126382 2020
3
Substernal goiter excision in a Jehovah's Witness. 61
32675989 2020
4
Peculiar anatomic variation of recurrent laryngeal nerve and EMG change in a patient with right substernal goiter and pre-operative vocal cord palsy-case report. 61
32775271 2020
5
Substernal Goiter with Carinal Involvement Presenting as Mediastinal Mass. 61
31126708 2020
6
Substernal Goiter: a case to remember. 61
32428142 2020
7
Ultrasound-Guided Percutaneous Microwave Ablation for Substernal Goiter: Initial Experience. 61
30900322 2019
8
Surgical approach to the substernal goiter. 61
31477522 2019
9
Presternal Goiter. 61
31133159 2019
10
Substernal goiter: Treatment and challenges. Twenty-two years of experience in diagnosis and management of substernal goiters. 61
30055961 2019
11
Substernal goiter presenting as acute respiratory failure. 61
29622368 2018
12
American Thyroid Association Statement on Postoperative Hypoparathyroidism: Diagnosis, Prevention, and Management in Adults. 61
29848235 2018
13
Morbidity of total thyroidectomy for substernal goiter: A series of 70 patients. 61
28602544 2018
14
Substernal Goiter: Correlation between Grade and Surgical Approach. 61
29580356 2018
15
Safety and Outcomes of the Transoral Endoscopic Thyroidectomy Vestibular Approach. 61
28877292 2018
16
Missed thyroid gland after total thyroidectomy. 61
30023979 2018
17
A Large Substernal Goiter that Extended to Both Sides of the Thorax. 61
30533243 2018
18
A Review of Methods for the Preservation of Laryngeal Nerves During Thyroidectomy. 61
32595378 2018
19
Mediastinal ectopic thyroid mass with normal thyroid function and location: Case report. 61
30292094 2018
20
Complication Risk in Secondary Thyroid Surgery. 61
32595366 2018
21
Substernal goiter and laryngopharyngeal reflux. 61
28658344 2017
22
Chylothorax Associated with Substernal Goiter in Graves' Disease Treated with Radioactive Iodine. 61
28835765 2017
23
[Assessment and surgical treatment for 58 substernal goiter]. 61
28395497 2017
24
Surgical treatment of substernal goiter: An analysis of 44 cases. 61
26995097 2017
25
Patient-tailored management of an asymptomatic massive substernal goiter presenting as brachiocephalic vein occlusion. Report of a case and review of sternotomy indications. 61
28095343 2017
26
Trans-cervical resection of a separate substernal goitre. 61
29156233 2017
27
Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. 61
27005286 2016
28
Erratum to: Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. 61
27387178 2016
29
Advanced vessel sealing devices in total thyroidectomy for substernal goitre: A retrospective cohort study. 61
27693824 2016
30
Surgical management of substernal goitres at a tertiary referral centre: A retrospective cohort study of 2,104 patients. 61
26796368 2016
31
Substernal goiter: Experience with 50 cases. 61
26520480 2016
32
Preoperative risk factors in total thyroidectomy of substernal goiter. 61
27932888 2016
33
Bilateral Chylothorax Secondary to Retrosternal Goitre: a Case Report and Review of the Literature. 61
30755867 2016
34
Haemostasis in Thyroid Surgery: Collagen-Fibrinogen-Thrombin Patch versus Cellulose Gauze-Our Experience. 61
27018148 2016
35
Substernal goiter: when is a sternotomy required? 61
25976851 2015
36
Substernal goiter 61
30754967 2015
37
Harmonic focus in thyroidectomy for substernal goiter. 61
25752670 2015
38
[In Process Citation]. 61
26284802 2015
39
Coexistence of Obstructive Sleep Apnea and Superior Vena Cava Syndromes Due to Substernal Goitre in a Patient With Respiratory Failure: A Case Report. 61
26082848 2015
40
Sternotomy for substernal goiter: retrospective study of 52 operations. 61
25691265 2015
41
Transient palsy of recurrent laryngeal nerve postresection of giant substernal goiter. 61
25798363 2014
42
Substernal goiter: when is a sternotomy required? 61
25058777 2014
43
eComment. Substernal goiter. Beware of the thyroidea ima artery. 61
24944323 2014
44
Recurrent laryngeal nerve palsy and substernal goiter. An Italian multicenter study. 61
24880605 2014
45
[Experience of managing substernal goiter by totally endoscopic procedure]. 61
24943035 2014
46
Best approach for posterior mediastinal goiter removal: transcervical incision and lateral thoracotomy. 61
24239133 2014
47
Single stage substernal thyroidectomy and off-pump coronary artery bypass grafting: is it worth using cardiopulmonary bypass unless absolutely necessary? 61
24722708 2014
48
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. 61
24228633 2013
49
Obstructive sleep apnea caused by substernal goiter presenting as nonarteritic ischemic optic neuropathy. 61
22899396 2013
50
Surgical treatment of large substernal thyroid goiter: analysis of 12 patients. 61
23936586 2013

Variations for Substernal Goiter

Expression for Substernal Goiter

Search GEO for disease gene expression data for Substernal Goiter.

Pathways for Substernal Goiter

Pathways related to Substernal Goiter according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.98 PTH GCM2
2 10.28 PTH CALCA

GO Terms for Substernal Goiter

Biological processes related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 8.96 PTH CALCA
2 cellular calcium ion homeostasis GO:0006874 8.8 PTH GCM2 CALCA

Molecular functions related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 TG PTH CALCA

Sources for Substernal Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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