MCID: SBS002
MIFTS: 27

Substernal Goiter

Categories: Endocrine diseases

Aliases & Classifications for Substernal Goiter

MalaCards integrated aliases for Substernal Goiter:

Name: Substernal Goiter 12 15 17 71
Retrosternal Thyroid Goiter 12
Retrosternal Thyroid Goitre 12
Goiter, Substernal 43
Substernal Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13200
MeSH 43 D006045
SNOMED-CT 67 66392007
UMLS 71 C0018024

Summaries for Substernal Goiter

MalaCards based summary : Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and hypoparathyroidism. An important gene associated with Substernal Goiter is HINT2 (Histidine Triad Nucleotide Binding Protein 2), and among its related pathways/superpathways is Transcription_Role of VDR in regulation of genes involved in osteoporosis. Affiliated tissues include thyroid, testes and bone.

Related Diseases for Substernal Goiter

Diseases related to Substernal Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 goiter 32.0 TG CALCA
2 hypoparathyroidism 31.0 PTH CALCA
3 papillary carcinoma 30.8 TG CALCA
4 thyroiditis 30.7 TG CALCA
5 multinodular goiter 30.6 TG PTH CALCA
6 nodular goiter 30.6 TG CALCA
7 follicular adenoma 30.6 TG CALCA
8 thyroid carcinoma 30.5 TG CALCA
9 graves disease 1 30.4 TG PTH CALCA
10 hyperthyroidism 30.4 TG PTH CALCA
11 parathyroid carcinoma 30.1 PTH CALCA
12 thyroid gland disease 30.1 TG PTH CALCA
13 primary hyperparathyroidism 29.7 PTH CALCA
14 dysphagia 10.6
15 tracheomalacia 10.3
16 respiratory failure 10.3
17 hypothyroidism 10.3
18 tracheal stenosis 10.3
19 thrombophilia due to thrombin defect 10.3
20 arteries, anomalies of 10.3
21 hyperlipoproteinemia, type iii 10.3
22 lipoprotein quantitative trait locus 10.3
23 pneumothorax 10.3
24 aortic aneurysm 10.3
25 adenoma 10.3
26 pulmonary embolism 10.3
27 clear cell adenoma 10.2 TG PTH
28 postsurgical hypothyroidism 10.2 TG PTH
29 tall cell variant papillary carcinoma 10.2 TG PTH
30 thyroid gland mucoepidermoid carcinoma 10.1 TG CALCA
31 mucoepidermoid carcinoma 10.1 TG CALCA
32 apnea, obstructive sleep 10.1
33 varicose veins 10.1
34 pulmonary hypertension 10.1
35 pulmonary edema 10.1
36 hemopericardium 10.1
37 horner's syndrome 10.1
38 pericardial effusion 10.1
39 systemic scleroderma 10.1
40 spindle epithelial tumor with thymus-like differentiation tumor 10.1 TG CALCA
41 plummer's disease 10.1 TG PTH
42 atypical follicular adenoma 10.1 TG CALCA
43 thyroid sarcoma 10.1 TG CALCA
44 isthmus cancer 10.1 TG CALCA
45 fetal adenoma 10.1 TG CALCA
46 hypothyroidism, congenital, nongoitrous, 1 10.1 TG PTH
47 nonencapsulated sclerosing carcinoma 10.1 TG CALCA
48 acute thyroiditis 10.1 TG CALCA
49 carotid body cancer 10.1 TG CALCA
50 epithelial malignant thymoma 10.1 TG CALCA

Graphical network of the top 20 diseases related to Substernal Goiter:



Diseases related to Substernal Goiter

Symptoms & Phenotypes for Substernal Goiter

Drugs & Therapeutics for Substernal Goiter

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Is the Use of Drain for Thyroid Surgery Realistic? Completed NCT01771523

Search NIH Clinical Center for Substernal Goiter

Cochrane evidence based reviews: goiter, substernal

Genetic Tests for Substernal Goiter

Anatomical Context for Substernal Goiter

MalaCards organs/tissues related to Substernal Goiter:

40
Thyroid, Testes, Bone, Lymph Node, Heart, Endothelial, Trachea

Publications for Substernal Goiter

Articles related to Substernal Goiter:

(show top 50) (show all 225)
# Title Authors PMID Year
1
Substernal Goiter: a case to remember. 61
32428142 2020
2
Substernal Goiter with Carinal Involvement Presenting as Mediastinal Mass. 61
31126708 2020
3
Ultrasound-Guided Percutaneous Microwave Ablation for Substernal Goiter: Initial Experience. 61
30900322 2019
4
Surgical approach to the substernal goiter. 61
31477522 2019
5
Presternal Goiter. 61
31133159 2019
6
Substernal goiter: Treatment and challenges. Twenty-two years of experience in diagnosis and management of substernal goiters. 61
30055961 2019
7
Substernal goiter presenting as acute respiratory failure. 61
29622368 2018
8
American Thyroid Association Statement on Postoperative Hypoparathyroidism: Diagnosis, Prevention, and Management in Adults. 61
29848235 2018
9
Morbidity of total thyroidectomy for substernal goiter: A series of 70 patients. 61
28602544 2018
10
Substernal Goiter: Correlation between Grade and Surgical Approach. 61
29580356 2018
11
Safety and Outcomes of the Transoral Endoscopic Thyroidectomy Vestibular Approach. 61
28877292 2018
12
Missed thyroid gland after total thyroidectomy. 61
30023979 2018
13
A Large Substernal Goiter that Extended to Both Sides of the Thorax. 61
30533243 2018
14
Mediastinal ectopic thyroid mass with normal thyroid function and location: Case report. 61
30292094 2018
15
Substernal goiter and laryngopharyngeal reflux. 61
28658344 2017
16
Chylothorax Associated with Substernal Goiter in Graves' Disease Treated with Radioactive Iodine. 61
28835765 2017
17
[Assessment and surgical treatment for 58 substernal goiter]. 61
28395497 2017
18
Surgical treatment of substernal goiter: An analysis of 44 cases. 61
26995097 2017
19
Patient-tailored management of an asymptomatic massive substernal goiter presenting as brachiocephalic vein occlusion. Report of a case and review of sternotomy indications. 61
28095343 2017
20
Trans-cervical resection of a separate substernal goitre. 61
29156233 2017
21
Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. 61
27005286 2016
22
Erratum to: Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. 61
27387178 2016
23
Advanced vessel sealing devices in total thyroidectomy for substernal goitre: A retrospective cohort study. 61
27693824 2016
24
Surgical management of substernal goitres at a tertiary referral centre: A retrospective cohort study of 2,104 patients. 61
26796368 2016
25
Substernal goiter: Experience with 50 cases. 61
26520480 2016
26
Preoperative risk factors in total thyroidectomy of substernal goiter. 61
27932888 2016
27
Bilateral Chylothorax Secondary to Retrosternal Goitre: a Case Report and Review of the Literature. 61
30755867 2016
28
Haemostasis in Thyroid Surgery: Collagen-Fibrinogen-Thrombin Patch versus Cellulose Gauze-Our Experience. 61
27018148 2016
29
Substernal goiter: when is a sternotomy required? 61
25976851 2015
30
Substernal goiter 61
30754967 2015
31
Harmonic focus in thyroidectomy for substernal goiter. 61
25752670 2015
32
[In Process Citation]. 61
26284802 2015
33
Coexistence of Obstructive Sleep Apnea and Superior Vena Cava Syndromes Due to Substernal Goitre in a Patient With Respiratory Failure: A Case Report. 61
26082848 2015
34
Sternotomy for substernal goiter: retrospective study of 52 operations. 61
25691265 2015
35
Transient palsy of recurrent laryngeal nerve postresection of giant substernal goiter. 61
25798363 2014
36
Substernal goiter: when is a sternotomy required? 61
25058777 2014
37
eComment. Substernal goiter. Beware of the thyroidea ima artery. 61
24944323 2014
38
[Experience of managing substernal goiter by totally endoscopic procedure]. 61
24943035 2014
39
Recurrent laryngeal nerve palsy and substernal goiter. An Italian multicenter study. 61
24880605 2014
40
Best approach for posterior mediastinal goiter removal: transcervical incision and lateral thoracotomy. 61
24239133 2014
41
Single stage substernal thyroidectomy and off-pump coronary artery bypass grafting: is it worth using cardiopulmonary bypass unless absolutely necessary? 61
24722708 2014
42
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. 61
24228633 2013
43
Obstructive sleep apnea caused by substernal goiter presenting as nonarteritic ischemic optic neuropathy. 61
22899396 2013
44
Surgical treatment of large substernal thyroid goiter: analysis of 12 patients. 61
23936586 2013
45
The "forgotten" goiter after total thyroidectomy. 61
23336990 2013
46
Postobstructive pulmonary edema associated with a substernal goitre. 61
23027909 2012
47
Forgotten goiter. Our experience and a review of the literature. 61
22699240 2012
48
Resection of a giant bilateral retrovascular intrathoracic goiter causing severe upper airway obstruction, 2 years after subtotal thyroidectomy: a case report and review of the literature. 61
23304440 2012
49
Positional dyspnea and tracheal compression as indications for goiter resection. 61
22430090 2012
50
Extraction of substernal goitre using an innovative vacuum device. 61
22334630 2012

Variations for Substernal Goiter

Expression for Substernal Goiter

Search GEO for disease gene expression data for Substernal Goiter.

Pathways for Substernal Goiter

Pathways related to Substernal Goiter according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.28 PTH CALCA

GO Terms for Substernal Goiter

Biological processes related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 8.96 PTH CALCA
2 stabilization of membrane potential GO:0030322 8.62 KCNK17 KCNK15

Molecular functions related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium channel activity GO:0005267 9.16 KCNK17 KCNK15
2 potassium ion leak channel activity GO:0022841 8.96 KCNK17 KCNK15
3 hormone activity GO:0005179 8.8 TG PTH CALCA

Sources for Substernal Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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