MCID: SDD008
MIFTS: 30

Sudden Sensorineural Hearing Loss

Categories: Ear diseases, Rare diseases
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Aliases & Classifications for Sudden Sensorineural Hearing Loss

MalaCards integrated aliases for Sudden Sensorineural Hearing Loss:

Name: Sudden Sensorineural Hearing Loss 19
Acute Sensorineural Hearing Loss by Acute Acoustic Trauma or Sudden Deafness or Surgery Induced Acoustic Trauma 19 58
Sudden Deafness 19

Characteristics:


Prevelance:

Acute Sensorineural Hearing Loss by Acute Acoustic Trauma or Sudden Deafness or Surgery Induced Acoustic Trauma: 1-5/10000 (Europe) 58

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Ear diseases
Orphanet: 58  
Rare otorhinolaryngological diseases


External Ids:

ICD10 via Orphanet 32 H83.3
Orphanet 58 ORPHA90059

Summaries for Sudden Sensorineural Hearing Loss

GARD: 19 Sudden sensorineural deafness is a condition that is characterized by rapid, unexplained hearing loss. More specifically, affected people experience a reduction in hearing of greater than 30 decibels, which may occur all at once or over several days. In most cases, only one ear is affected. People with sudden sensorineural deafness often become dizzy, have ringing in their ears (tinnitus), or both (40% of the cases). The condition has a variety of causes, including infection, inflammation, tumors, trauma, exposure to toxins and conditions that affect the inner ear such as Ménière's disease.

MalaCards based summary: Sudden Sensorineural Hearing Loss, also known as acute sensorineural hearing loss by acute acoustic trauma or sudden deafness or surgery induced acoustic trauma, is related to sensorineural hearing loss and acoustic neuroma. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include brain, neutrophil and bone.

Related Diseases for Sudden Sensorineural Hearing Loss

Diseases related to Sudden Sensorineural Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 386)
# Related Disease Score Top Affiliating Genes
1 sensorineural hearing loss 11.6
2 acoustic neuroma 10.8
3 meniere disease 10.7
4 neurilemmoma 10.7
5 vertigo, benign recurrent 10.7
6 autoimmune disease 10.7
7 labyrinthitis 10.7
8 viral infectious disease 10.7
9 vascular disease 10.6
10 antiphospholipid syndrome 10.6
11 pathologic nystagmus 10.6
12 lipid metabolism disorder 10.6
13 otitis media 10.6
14 abdominal obesity-metabolic syndrome 1 10.6
15 covid-19 10.6
16 neuroma 10.6
17 hypercholesterolemia, familial, 1 10.6
18 migraine with or without aura 1 10.5
19 bell's palsy 10.5
20 neuritis 10.5
21 inner ear disease 10.5
22 systemic lupus erythematosus 10.5
23 stroke, ischemic 10.5
24 lyme disease 10.5
25 vestibular neuronitis 10.5
26 herpes simplex 10.5
27 lupus erythematosus 10.5
28 systemic lupus erythematosus 1 10.5
29 severe acute respiratory syndrome 10.5
30 hyperglycemia 10.5
31 herpes zoster 10.5
32 oculodentodigital dysplasia 10.5
33 papillon-lefevre syndrome 10.5
34 hyperhomocysteinemia 10.5
35 tatton-brown-rahman syndrome 10.5
36 familial hyperlipidemia 10.5
37 viral labyrinthitis 10.5
38 facial paralysis 10.5
39 cerebrovascular disease 10.5
40 vasculitis 10.5
41 sickle cell anemia 10.4
42 meningioma, familial 10.4
43 mumps 10.4
44 chronic kidney disease 10.4
45 chickenpox 10.4
46 perilymphatic fistula 10.4
47 hypertriglyceridemia 1 10.4
48 hypoascorbemia 10.4
49 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 10.4
50 nasopharyngeal carcinoma 10.4

Graphical network of the top 20 diseases related to Sudden Sensorineural Hearing Loss:



Diseases related to Sudden Sensorineural Hearing Loss

Symptoms & Phenotypes for Sudden Sensorineural Hearing Loss

Drugs & Therapeutics for Sudden Sensorineural Hearing Loss

Drugs for Sudden Sensorineural Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7 4897
9
Ginkgo Phase 4
10 Antineoplastic Agents, Hormonal Phase 4
11 Hormones Phase 4
12 Hormone Antagonists Phase 4
13 glucocorticoids Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Neuroprotective Agents Phase 4
16 Antiemetics Phase 4
17
Methylprednisolone Acetate Phase 4 584547
18 Gastrointestinal Agents Phase 4
19 Protective Agents Phase 4
20 BB 1101 Phase 4
21 Antimetabolites Phase 4
22 Hypolipidemic Agents Phase 4
23 Anticholesteremic Agents Phase 4
24 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
25 Lipid Regulating Agents Phase 4
26
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
27 Anesthetics Phase 3
28
Ancrod Approved, Investigational Phase 1, Phase 2 9046-56-4
29
Topiramate Approved Phase 2 97240-79-4 5284627
30 Fibrinolytic Agents Phase 1, Phase 2
31 Anticoagulants Phase 1, Phase 2
32 Dexamethasone 21-phosphate Phase 2
33 HIV Protease Inhibitors Phase 2
34
protease inhibitors Phase 2
35 Anticonvulsants Phase 2
36 Hypoglycemic Agents Phase 2
37
Phenol Approved, Experimental Early Phase 1 108-95-2 996
38
Tetracaine Approved, Vet_approved Early Phase 1 94-24-6 5411
39
Lidocaine Approved, Vet_approved 137-58-6 3676
40
Mecobalamin Approved, Investigational 13422-55-4
41
Fludrocortisone Approved, Investigational Early Phase 1 127-31-1 31378
42 Antiviral Agents
43 interferons
44 Interferon-alpha
45 Pharmaceutical Solutions Early Phase 1
46 Anti-Infective Agents Early Phase 1
47 Anesthetics, Local Early Phase 1
48 Disinfectants Early Phase 1
49 Anti-Infective Agents, Local Early Phase 1
50 Sclerosing Solutions Early Phase 1

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 The Effect of Positive Airway Pressure on Idiopathic Sudden Sensorineural Hearing Loss Comorbided With Obstructive Sleep Apnea: A Clinical Randomized Controlled Study Recruiting NCT04192656 Phase 4 Methylprednisolone Hemisuccinate;Ginaton
2 Towards a Self-Administered Hearing Protection Regimen Not yet recruiting NCT04826237 Phase 4 Statin;methylprednisolone;dexamethasone;Placebo
3 Bed Rest for Idiopathic Sudden Sensorineural Hearing Loss Unknown status NCT00416143 Phase 2, Phase 3 prednisone - oral corticosteroid 1mg/kg/D for 1 week
4 A Phase III Multicenter, Double-blind, Placebo-controlled, Study Evaluating the Safety, and Efficacy of STR001 Treatment in Adults With Sudden Sensorineural Hearing Loss Completed NCT03331627 Phase 3 STR001-IT and STR001-ER
5 A Two-part, Randomized, Double-blind, Placebo-controlled, Parallel-group, Efficacy and Safety Study of SENS-401 in Subjects With Severe or Profound Sudden Sensorineural Hearing Loss Completed NCT03603314 Phase 2, Phase 3 SENS-401
6 A Prospective, Randomized, Double Blind, Placebo Controlled, Multicenter Study on the Safety and Efficacy of Continuous Infusion of Corticosteroid Delivered Via Catheter in Patients With Idiopathic Sudden Sensorineural Hearing Loss Completed NCT00335920 Phase 3 Dexamethasone-dihydrogenphosphate (4mg/ml)
7 Sudden Hearing Loss Multicenter Treatment Trial Completed NCT00097448 Phase 3 prednisone;methylprednisolone sodium succinate
8 Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment Terminated NCT02809118 Phase 3 AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
9 Double-blind, Randomized, Placebo-controlled Study on Efficacy, Safety and Tolerability of Ancrod in Patients With Sudden Sensorineural Hearing Loss (SSHL) Completed NCT01621256 Phase 1, Phase 2 Ancrod;Saline solution
10 A Phase 2a, Prospective, Randomized, Double-Blind, Placebo-Controlled, Single and Repeat-Dose, Multicenter, Exploratory Efficacy Study of FX-322 Administered by Intratympanic Injection in Adults With Stable Sensorineural Hearing Loss Completed NCT04120116 Phase 2 FX-322 (One Dose);FX-322 (Two Doses);FX-322 (Four Doses);Placebo
11 High Dose Oral Steroids in Sudden Sensorineural Hearing Loss Recruiting NCT03255473 Phase 2 Dexamethasone;Prednisone
12 The Role of Migraine Prophylaxis Agent Topiramate in Treating Patients With Sudden Sensorineural Hearing Loss Recruiting NCT05403229 Phase 2 Topiramate;Systemic Steroids
13 Phase I Clinical Study on the Safety, Tolerance, Efficacy and Pharmacokinetics of Repeated Intratympanic HY01 in Patients With Sudden Sensorineural Hearing Loss Recruiting NCT04961099 Phase 1 HY01
14 The Evaluation of the Ischemia-modified Albumin Levels in the Patients With Sudden Sensorineural Hearing Loss Unknown status NCT03706183
15 Video HIT Results in Sudden Sensorineural Hearing Loss Patients Unknown status NCT04224909
16 Vestibular Prognosis Assessment of the Idiopathic Sudden Sensorineural Hearing Loss With Vestibular Dysfunction Treated With Oral or Intratympanic Glucocorticoids Unknown status NCT03974867 Prednisone 5Mg Tab;Methylprednisolone 40 mg
17 The Registry of Hyperbaric Oxygen Therapy Treated Patients Unknown status NCT02483650
18 Prospective Study of Sudden Deafness Unknown status NCT04129983
19 Prevalence of Obstructive Sleep Apnea Syndrome in Patients With a History of Sudden Sensorineural Hearing Loss Completed NCT03747874
20 Prognosis of Vestibular Dysfunction in Patients With Idiopathic Sudden Sensorineural Hearing Loss Completed NCT03951584
21 The Effect of Antiviral Therapy With Pegylated Interferon-alpha for Chronic Hepatitis C and B on Auditory Disability: A Prospective Study Completed NCT01265693
22 The Effect of Inhaled Hydrogen on the Prognosis of Idiopathic Sudden Sensorineural Hearing Loss Recruiting NCT04881435
23 Prospective Cohort Study of Sudden Sensorineural Hearing Loss in Wonju Severance Christian Hospital Recruiting NCT05474963
24 Comparing Topical Tetracaine Drops to Topical Focal Phenol for Local Anesthesia During Intratympanic Steroid Injection Recruiting NCT04794842 Early Phase 1 Tetracaine 5% drops;Phenol 90% concentration
25 Effect of Ultrasound-guided Stellate Ganglion Block Combined With Facial Nerve and Glossopharyngeal Nerve Block on the Treatment of Sudden Deafness Recruiting NCT05623384 Mecobalamin Tablets
26 Correlation Between Peripheral Hearing Loss and Auditory Perception Impairment in Patients With Unilateral Sudden Deafness and Its Underlying Neural Mechanism Not yet recruiting NCT05608161
27 Mineralocorticoid Treatment for Sudden Sensorineural Hearing Loss Terminated NCT01186185 Early Phase 1 Fludrocortisone

Search NIH Clinical Center for Sudden Sensorineural Hearing Loss

Genetic Tests for Sudden Sensorineural Hearing Loss

Anatomical Context for Sudden Sensorineural Hearing Loss

Organs/tissues related to Sudden Sensorineural Hearing Loss:

MalaCards : Brain, Neutrophil, Bone, Endothelial, Thyroid, Temporal Lobe, Cortex

Publications for Sudden Sensorineural Hearing Loss

Articles related to Sudden Sensorineural Hearing Loss:

(show top 50) (show all 3190)
# Title Authors PMID Year
1
Prognosis of Idiopathic Sudden Sensorineural Hearing Loss: The Nomogram Perspective. 62
35081764 2023
2
Effect of Combining Sound Therapy with Pharmacotherapy on the Recovery of Hearing Abilities in the Case of Sudden Sensorineural Hearing Loss: A Prospective Study. 62
36151448 2022
3
Direction-changing spontaneous nystagmus in patients with dizziness. 62
36454383 2022
4
Risk factors associated with idiopathic sudden sensorineural hearing loss in pregnant South Korean women: a nationwide population-based study. 62
34256656 2022
5
Standardization of Outcome Measures for Intratympanic Steroid Treatment for Idiopathic Sudden Sensorineural Hearing Loss. 62
36190905 2022
6
COVID-19 and transtympanic injections for sudden sensorineural hearing loss. 62
36470008 2022
7
Sudden sensorineural hearing loss: Recovery rates according to audiometric patterns. 62
36404098 2022
8
Analysis of clinical features and prognostic correlation factors of sudden sensorineural hearing loss in children. 62
36446225 2022
9
The relationship between thiol-disulfide balance and idiopathic sudden sensorineural hearing loss. 62
33642215 2022
10
Sudden sensorineural hearing loss as an initial presentation in multiple sclerosis. 62
36182813 2022
11
Uncovering Novel Prognostic Factors of Sudden Sensorineural Hearing Loss by Whole-Genome Sequencing of Cell-Free DNA. 62
36349665 2022
12
Characteristics and prognosis analysis of bilateral sudden sensorineural hearing loss: A retrospective case-control study. 62
36087103 2022
13
Analysis of clinical parameters as predictors of hearing recovery in patients with sudden sensorineural hearing loss. 62
36064815 2022
14
Thromboelastography predicting the prognosis of sudden sensorineural hearing loss. 62
35818895 2022
15
Assessment of prestin level changes as an inner-ear biomarker in patients with idiopathic sudden sensorineural hearing loss. 62
35815695 2022
16
Effects of endolymphatic space volume on discrepancy of results between caloric test and video head impulse test. 62
36446684 2022
17
Repurposable Drugs That Interact with Steroid Responsive Gene Targets for Inner Ear Disease. 62
36358991 2022
18
Late-Onset Ornithine Transcarbamylase Deficiency Complicated with Extremely High Serum Ammonia Level: Prompt Induction of Hemodialysis as the Key to Successful Treatment. 62
36377209 2022
19
Corticosteroid Use in Otolaryngology: Current Considerations During the COVID-19 Era. 62
34874793 2022
20
Melatonin Alleviates the Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway. 62
36334193 2022
21
Post-irradiation endolymphatic hydrops vs. post-irradiation sudden deafness. 62
36265683 2022
22
Evaluation of von Willebrand factor and protein/creatinine ratio in idiopathic sudden hearing loss. 62
36427796 2022
23
Intratympanic steroid treatment can reduce ROS and immune response in human perilymph investigated by in-depth proteome analysis. 62
36259158 2022
24
[From guideline to clinical practice:discussion of guideline for diagnosis and treatment of sudden deafness (2015)]. 62
36319134 2022
25
The association between metabolic syndrome and the prognosis of idiopathic sudden sensorineural hearing loss. 62
36210371 2022
26
ENT characteristics and therapeutic results in multisystemic disorders of mitochondrial encephalomyopathy. 62
36309717 2022
27
Sudden Sensorineural Hearing Loss Post Coronavirus Disease: A Systematic Review of Case Reports. 62
34277383 2022
28
Frequency-specific prediction model of hearing outcomes in patients with idiopathic sudden sensorineural hearing loss. 62
35015092 2022
29
Real life safety of systemic steroids for sudden sensorineural hearing loss: a chart review. 62
35059792 2022
30
Lyme neuroborreliosis as a cause of sudden sensorineural hearing loss and facial palsy. 62
36245466 2022
31
Migrainous Vertigo, Tinnitus, and Ear Symptoms and Alternatives. 62
36150941 2022
32
Diagnostic value and prognostic significance of MRI findings in sudden sensorineural hearing loss. 62
36258869 2022
33
Is Idiopathic Sudden Sensorineural Hearing Loss Seasonal? 62
36040043 2022
34
Correlation of Neutrophil-to-Lymphocyte Ratio and the Dilation of the Basilar Artery with the Potential Role of Vascular Compromise in the Pathophysiology of Idiopathic Sudden Sensorineural Hearing Loss. 62
36233809 2022
35
Epidemiology of idiopathic sudden sensorineural hearing loss in the era of big data. 62
36239782 2022
36
Otoacoustic emissions value in patients with idiopathic sudden sensorineural hearing loss. 62
36249922 2022
37
The Influence of Steroid Therapy on the Treatment Results in Patients with Sudden Sensorineural Hearing Loss. 62
36294406 2022
38
Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss. 62
36258873 2022
39
Vascular loops in cerebellopontine angle in patients with unilateral idiopathic sudden sensorineural hearing loss: Evaluations by three radiological grading systems. 62
36258879 2022
40
Idiopathic Sudden Sensorineural Hearing Loss: Is Hyperbaric Oxygen Treatment the Sooner and Longer, the Better? 62
36294791 2022
41
Inflammatory Indicators in Peripheral Blood in Sudden Sensorineural Hearing Loss Patients With Different Shape of Audiograms. 62
36250504 2022
42
Update on Findings about Sudden Sensorineural Hearing Loss and Insight into Its Pathogenesis. 62
36362614 2022
43
Combination of Hyperbaric Oxygen Therapy and Oral Steroids for the Treatment of Sudden Sensorineural Hearing Loss: Early or Late? 62
36295581 2022
44
Injected 3T-3D-FLAIR-MRI labyrinthine patterns match with the severity and tonotopic alteration in sudden sensorineural hearing loss. 62
35286438 2022
45
Better late than never: initial experience of intra-arterial pulsed-urokinase-injection as a salvage therapy for refractory sudden sensorineural hearing loss. 62
34726104 2022
46
Salvage intratympanic steroid therapy for sudden sensorineural hearing loss: our real-life experience in 32 patients. 62
35018883 2022
47
Bilateral sensorineural hearing loss after opioid overdose in an adolescent male. 62
36148640 2022
48
Sudden Sensorineural Hearing Loss: A Review. 62
36299969 2022
49
Pretreatment hearing grades and hearing recovery outcomes after primary hyperbaric oxygen treatment in patients with idiopathic sudden sensorineural hearing loss. 62
36100930 2022
50
The effectiveness of hyperbaric oxygen therapy on the final outcome of patients with sudden sensorineural hearing loss. 62
35952529 2022

Variations for Sudden Sensorineural Hearing Loss

Expression for Sudden Sensorineural Hearing Loss

Search GEO for disease gene expression data for Sudden Sensorineural Hearing Loss.

Pathways for Sudden Sensorineural Hearing Loss

GO Terms for Sudden Sensorineural Hearing Loss

Sources for Sudden Sensorineural Hearing Loss

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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