Sudden Sensorineural Hearing Loss disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SDD008 MIFTS: 30	Sudden Sensorineural Hearing Loss Categories: Ear diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Tissues Related diseases Publications Drugs Expand all tables

Sources

Aliases & Classifications for Sudden Sensorineural Hearing Loss

MalaCards integrated aliases for Sudden Sensorineural Hearing Loss:

Name: Sudden Sensorineural Hearing Loss ¹⁹

Acute Sensorineural Hearing Loss by Acute Acoustic Trauma or Sudden Deafness or Surgery Induced Acoustic Trauma ¹⁹ ⁵⁸

Sudden Deafness ¹⁹

Characteristics:

Prevelance:

Acute Sensorineural Hearing Loss by Acute Acoustic Trauma or Sudden Deafness or Surgery Induced Acoustic Trauma: 1-5/10000 (Europe) ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Ear diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the ear and mastoid process

Diseases of inner ear

Other diseases of inner ear

Noise effects on inner ear

Orphanet: ⁵⁸

Rare otorhinolaryngological diseases

External Ids:

ICD10 via Orphanet ³² H83.3

Orphanet ⁵⁸ ORPHA90059

Sources

Summaries for Sudden Sensorineural Hearing Loss

GARD: ¹⁹ Sudden sensorineural deafness is a condition that is characterized by rapid, unexplained hearing loss. More specifically, affected people experience a reduction in hearing of greater than 30 decibels, which may occur all at once or over several days. In most cases, only one ear is affected. People with sudden sensorineural deafness often become dizzy, have ringing in their ears (tinnitus), or both (40% of the cases). The condition has a variety of causes, including infection, inflammation, tumors, trauma, exposure to toxins and conditions that affect the inner ear such as Ménière's disease.

MalaCards based summary: Sudden Sensorineural Hearing Loss, also known as acute sensorineural hearing loss by acute acoustic trauma or sudden deafness or surgery induced acoustic trauma, is related to sensorineural hearing loss and acoustic neuroma. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include brain, neutrophil and bone.

Sources

Related Diseases for Sudden Sensorineural Hearing Loss

Diseases related to Sudden Sensorineural Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 386)

#	Related Disease	Score
1	sensorineural hearing loss	11.6
2	acoustic neuroma	10.8
3	meniere disease	10.7
4	neurilemmoma	10.7
5	vertigo, benign recurrent	10.7
6	autoimmune disease	10.7
7	labyrinthitis	10.7
8	viral infectious disease	10.7
9	vascular disease	10.6
10	antiphospholipid syndrome	10.6
11	pathologic nystagmus	10.6
12	lipid metabolism disorder	10.6
13	otitis media	10.6
14	abdominal obesity-metabolic syndrome 1	10.6
15	covid-19	10.6
16	neuroma	10.6
17	hypercholesterolemia, familial, 1	10.6
18	migraine with or without aura 1	10.5
19	bell's palsy	10.5
20	neuritis	10.5
21	inner ear disease	10.5
22	systemic lupus erythematosus	10.5
23	stroke, ischemic	10.5
24	lyme disease	10.5
25	vestibular neuronitis	10.5
26	herpes simplex	10.5
27	lupus erythematosus	10.5
28	systemic lupus erythematosus 1	10.5
29	severe acute respiratory syndrome	10.5
30	hyperglycemia	10.5
31	herpes zoster	10.5
32	oculodentodigital dysplasia	10.5
33	papillon-lefevre syndrome	10.5
34	hyperhomocysteinemia	10.5
35	tatton-brown-rahman syndrome	10.5
36	familial hyperlipidemia	10.5
37	viral labyrinthitis	10.5
38	facial paralysis	10.5
39	cerebrovascular disease	10.5
40	vasculitis	10.5
41	sickle cell anemia	10.4
42	meningioma, familial	10.4
43	mumps	10.4
44	chronic kidney disease	10.4
45	chickenpox	10.4
46	perilymphatic fistula	10.4
47	hypertriglyceridemia 1	10.4
48	hypoascorbemia	10.4
49	deafness, autosomal recessive 4, with enlarged vestibular aqueduct	10.4
50	nasopharyngeal carcinoma	10.4

Graphical network of the top 20 diseases related to Sudden Sensorineural Hearing Loss:

Sources

Symptoms & Phenotypes for Sudden Sensorineural Hearing Loss

Sources

Drugs & Therapeutics for Sudden Sensorineural Hearing Loss

Drugs for Sudden Sensorineural Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4

50-02-2

3003 5743

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

4897

Ginkgo

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

Hormones

Phase 4

Hormone Antagonists

Phase 4

glucocorticoids

Phase 4

Anti-Inflammatory Agents

Phase 4

Neuroprotective Agents

Phase 4

Antiemetics

Phase 4

Methylprednisolone Acetate

Phase 4

584547

Gastrointestinal Agents

Phase 4

Protective Agents

Phase 4

BB 1101

Phase 4

Antimetabolites

Phase 4

Hypolipidemic Agents

Phase 4

Anticholesteremic Agents

Phase 4

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 4

Lipid Regulating Agents

Phase 4

Prednisone

Approved, Vet_approved

Phase 3

53-03-2

5865

Anesthetics

Phase 3

Ancrod

Approved, Investigational

Phase 1, Phase 2

9046-56-4

Topiramate

Approved

Phase 2

97240-79-4

5284627

Fibrinolytic Agents

Phase 1, Phase 2

Anticoagulants

Phase 1, Phase 2

Dexamethasone 21-phosphate

Phase 2

HIV Protease Inhibitors

Phase 2

protease inhibitors

Phase 2

Anticonvulsants

Phase 2

Hypoglycemic Agents

Phase 2

Phenol

Approved, Experimental

Early Phase 1

108-95-2

996

Tetracaine

Approved, Vet_approved

Early Phase 1

94-24-6

5411

Lidocaine

Approved, Vet_approved

137-58-6

3676

Mecobalamin

Approved, Investigational

13422-55-4

Fludrocortisone

Approved, Investigational

Early Phase 1

127-31-1

31378

Antiviral Agents

interferons

Interferon-alpha

Pharmaceutical Solutions

Early Phase 1

Anti-Infective Agents

Early Phase 1

Anesthetics, Local

Early Phase 1

Disinfectants

Early Phase 1

Anti-Infective Agents, Local

Early Phase 1

Sclerosing Solutions

Early Phase 1

Interventional clinical trials:

(show all 27)

#	Name	Status	NCT ID	Phase	Drugs
1	The Effect of Positive Airway Pressure on Idiopathic Sudden Sensorineural Hearing Loss Comorbided With Obstructive Sleep Apnea: A Clinical Randomized Controlled Study	Recruiting	NCT04192656	Phase 4	Methylprednisolone Hemisuccinate;Ginaton
2	Towards a Self-Administered Hearing Protection Regimen	Not yet recruiting	NCT04826237	Phase 4	Statin;methylprednisolone;dexamethasone;Placebo
3	Bed Rest for Idiopathic Sudden Sensorineural Hearing Loss	Unknown status	NCT00416143	Phase 2, Phase 3	prednisone - oral corticosteroid 1mg/kg/D for 1 week
4	A Phase III Multicenter, Double-blind, Placebo-controlled, Study Evaluating the Safety, and Efficacy of STR001 Treatment in Adults With Sudden Sensorineural Hearing Loss	Completed	NCT03331627	Phase 3	STR001-IT and STR001-ER
5	A Two-part, Randomized, Double-blind, Placebo-controlled, Parallel-group, Efficacy and Safety Study of SENS-401 in Subjects With Severe or Profound Sudden Sensorineural Hearing Loss	Completed	NCT03603314	Phase 2, Phase 3	SENS-401
6	A Prospective, Randomized, Double Blind, Placebo Controlled, Multicenter Study on the Safety and Efficacy of Continuous Infusion of Corticosteroid Delivered Via Catheter in Patients With Idiopathic Sudden Sensorineural Hearing Loss	Completed	NCT00335920	Phase 3	Dexamethasone-dihydrogenphosphate (4mg/ml)
7	Sudden Hearing Loss Multicenter Treatment Trial	Completed	NCT00097448	Phase 3	prednisone;methylprednisolone sodium succinate
8	Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment	Terminated	NCT02809118	Phase 3	AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
9	Double-blind, Randomized, Placebo-controlled Study on Efficacy, Safety and Tolerability of Ancrod in Patients With Sudden Sensorineural Hearing Loss (SSHL)	Completed	NCT01621256	Phase 1, Phase 2	Ancrod;Saline solution
10	A Phase 2a, Prospective, Randomized, Double-Blind, Placebo-Controlled, Single and Repeat-Dose, Multicenter, Exploratory Efficacy Study of FX-322 Administered by Intratympanic Injection in Adults With Stable Sensorineural Hearing Loss	Completed	NCT04120116	Phase 2	FX-322 (One Dose);FX-322 (Two Doses);FX-322 (Four Doses);Placebo
11	High Dose Oral Steroids in Sudden Sensorineural Hearing Loss	Recruiting	NCT03255473	Phase 2	Dexamethasone;Prednisone
12	The Role of Migraine Prophylaxis Agent Topiramate in Treating Patients With Sudden Sensorineural Hearing Loss	Recruiting	NCT05403229	Phase 2	Topiramate;Systemic Steroids
13	Phase I Clinical Study on the Safety, Tolerance, Efficacy and Pharmacokinetics of Repeated Intratympanic HY01 in Patients With Sudden Sensorineural Hearing Loss	Recruiting	NCT04961099	Phase 1	HY01
14	The Evaluation of the Ischemia-modified Albumin Levels in the Patients With Sudden Sensorineural Hearing Loss	Unknown status	NCT03706183
15	Video HIT Results in Sudden Sensorineural Hearing Loss Patients	Unknown status	NCT04224909
16	Vestibular Prognosis Assessment of the Idiopathic Sudden Sensorineural Hearing Loss With Vestibular Dysfunction Treated With Oral or Intratympanic Glucocorticoids	Unknown status	NCT03974867		Prednisone 5Mg Tab;Methylprednisolone 40 mg
17	The Registry of Hyperbaric Oxygen Therapy Treated Patients	Unknown status	NCT02483650
18	Prospective Study of Sudden Deafness	Unknown status	NCT04129983
19	Prevalence of Obstructive Sleep Apnea Syndrome in Patients With a History of Sudden Sensorineural Hearing Loss	Completed	NCT03747874
20	Prognosis of Vestibular Dysfunction in Patients With Idiopathic Sudden Sensorineural Hearing Loss	Completed	NCT03951584
21	The Effect of Antiviral Therapy With Pegylated Interferon-alpha for Chronic Hepatitis C and B on Auditory Disability: A Prospective Study	Completed	NCT01265693
22	The Effect of Inhaled Hydrogen on the Prognosis of Idiopathic Sudden Sensorineural Hearing Loss	Recruiting	NCT04881435
23	Prospective Cohort Study of Sudden Sensorineural Hearing Loss in Wonju Severance Christian Hospital	Recruiting	NCT05474963
24	Comparing Topical Tetracaine Drops to Topical Focal Phenol for Local Anesthesia During Intratympanic Steroid Injection	Recruiting	NCT04794842	Early Phase 1	Tetracaine 5% drops;Phenol 90% concentration
25	Effect of Ultrasound-guided Stellate Ganglion Block Combined With Facial Nerve and Glossopharyngeal Nerve Block on the Treatment of Sudden Deafness	Recruiting	NCT05623384		Mecobalamin Tablets
26	Correlation Between Peripheral Hearing Loss and Auditory Perception Impairment in Patients With Unilateral Sudden Deafness and Its Underlying Neural Mechanism	Not yet recruiting	NCT05608161
27	Mineralocorticoid Treatment for Sudden Sensorineural Hearing Loss	Terminated	NCT01186185	Early Phase 1	Fludrocortisone

Search NIH Clinical Center for Sudden Sensorineural Hearing Loss

Sources

Genetic Tests for Sudden Sensorineural Hearing Loss

Sources

Anatomical Context for Sudden Sensorineural Hearing Loss

Organs/tissues related to Sudden Sensorineural Hearing Loss:

MalaCards : Brain, Neutrophil, Bone, Endothelial, Thyroid, Temporal Lobe, Cortex

Sources

Publications for Sudden Sensorineural Hearing Loss

Articles related to Sudden Sensorineural Hearing Loss:

(show top 50) (show all 3190)

#	Title	Authors	PMID	Year
1	Prognosis of Idiopathic Sudden Sensorineural Hearing Loss: The Nomogram Perspective. ⁶²	Wu H...Xiong Y	35081764	2023
2	Effect of Combining Sound Therapy with Pharmacotherapy on the Recovery of Hearing Abilities in the Case of Sudden Sensorineural Hearing Loss: A Prospective Study. ⁶²	Sun Y...Dong H	36151448	2022
3	Direction-changing spontaneous nystagmus in patients with dizziness. ⁶²	Lee J...Kim CH	36454383	2022
4	Risk factors associated with idiopathic sudden sensorineural hearing loss in pregnant South Korean women: a nationwide population-based study. ⁶²	Kim HS...Hwang HS	34256656	2022
5	Standardization of Outcome Measures for Intratympanic Steroid Treatment for Idiopathic Sudden Sensorineural Hearing Loss. ⁶²	Osafo NK...Luo J	36190905	2022
6	COVID-19 and transtympanic injections for sudden sensorineural hearing loss. ⁶²	Adams JK...Erbele ID	36470008	2022
7	Sudden sensorineural hearing loss: Recovery rates according to audiometric patterns. ⁶²	Waissbluth S...Urzua P	36404098	2022
8	Analysis of clinical features and prognostic correlation factors of sudden sensorineural hearing loss in children. ⁶²	Xiao L...Su S	36446225	2022
9	The relationship between thiol-disulfide balance and idiopathic sudden sensorineural hearing loss. ⁶²	Cetin YS...Erel O	33642215	2022
10	Sudden sensorineural hearing loss as an initial presentation in multiple sclerosis. ⁶²	Yong HYF...Camara-Lemarroy CR	36182813	2022
11	Uncovering Novel Prognostic Factors of Sudden Sensorineural Hearing Loss by Whole-Genome Sequencing of Cell-Free DNA. ⁶²	Yang A...Li Q	36349665	2022
12	Characteristics and prognosis analysis of bilateral sudden sensorineural hearing loss: A retrospective case-control study. ⁶²	Wang Y...Wang M	36087103	2022
13	Analysis of clinical parameters as predictors of hearing recovery in patients with sudden sensorineural hearing loss. ⁶²	Poljak NK...Vucemilovic MZ	36064815	2022
14	Thromboelastography predicting the prognosis of sudden sensorineural hearing loss. ⁶²	Chen L...Wang M	35818895	2022
15	Assessment of prestin level changes as an inner-ear biomarker in patients with idiopathic sudden sensorineural hearing loss. ⁶²	Saadat F...Akbari M	35815695	2022
16	Effects of endolymphatic space volume on discrepancy of results between caloric test and video head impulse test. ⁶²	Ueda K...Kitahara T	36446684	2022
17	Repurposable Drugs That Interact with Steroid Responsive Gene Targets for Inner Ear Disease. ⁶²	Missner AA...Hoa M	36358991	2022
18	Late-Onset Ornithine Transcarbamylase Deficiency Complicated with Extremely High Serum Ammonia Level: Prompt Induction of Hemodialysis as the Key to Successful Treatment. ⁶²	Yamamoto S...Yamashita SI	36377209	2022
19	Corticosteroid Use in Otolaryngology: Current Considerations During the COVID-19 Era. ⁶²	Chang CWD...Brenner MJ	34874793	2022
20	Melatonin Alleviates the Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway. ⁶²	Zheng Y...Cong N	36334193	2022
21	Post-irradiation endolymphatic hydrops vs. post-irradiation sudden deafness. ⁶²	Tien CT...Young YH	36265683	2022
22	Evaluation of von Willebrand factor and protein/creatinine ratio in idiopathic sudden hearing loss. ⁶²	Caglar Cil O...Oymak S	36427796	2022
23	Intratympanic steroid treatment can reduce ROS and immune response in human perilymph investigated by in-depth proteome analysis. ⁶²	Jung JW...Oh SH	36259158	2022
24	[From guideline to clinical practice:discussion of guideline for diagnosis and treatment of sudden deafness (2015)]. ⁶²	Ma X...Jin X	36319134	2022
25	The association between metabolic syndrome and the prognosis of idiopathic sudden sensorineural hearing loss. ⁶²	Zand V...Fazilati M	36210371	2022
26	ENT characteristics and therapeutic results in multisystemic disorders of mitochondrial encephalomyopathy. ⁶²	Long H...Huang L	36309717	2022
27	Sudden Sensorineural Hearing Loss Post Coronavirus Disease: A Systematic Review of Case Reports. ⁶²	Umashankar A...Prabhu P	34277383	2022
28	Frequency-specific prediction model of hearing outcomes in patients with idiopathic sudden sensorineural hearing loss. ⁶²	Kawamura Y...Kitamura T	35015092	2022
29	Real life safety of systemic steroids for sudden sensorineural hearing loss: a chart review. ⁶²	Halevy N...Ungar OJ	35059792	2022
30	Lyme neuroborreliosis as a cause of sudden sensorineural hearing loss and facial palsy. ⁶²	Nitro L...Saibene AM	36245466	2022
31	Migrainous Vertigo, Tinnitus, and Ear Symptoms and Alternatives. ⁶²	Abouzari M...Djalilian HR	36150941	2022
32	Diagnostic value and prognostic significance of MRI findings in sudden sensorineural hearing loss. ⁶²	Todic J...Becker M	36258869	2022
33	Is Idiopathic Sudden Sensorineural Hearing Loss Seasonal? ⁶²	Simani L...Ungar OJ	36040043	2022
34	Correlation of Neutrophil-to-Lymphocyte Ratio and the Dilation of the Basilar Artery with the Potential Role of Vascular Compromise in the Pathophysiology of Idiopathic Sudden Sensorineural Hearing Loss. ⁶²	Kang DW...Sunwoo W	36233809	2022
35	Epidemiology of idiopathic sudden sensorineural hearing loss in the era of big data. ⁶²	Yoon CY...Ahn JJ	36239782	2022
36	Otoacoustic emissions value in patients with idiopathic sudden sensorineural hearing loss. ⁶²	El-Sayed El-Sayed Gaafar A...Zaghloul HS	36249922	2022
37	The Influence of Steroid Therapy on the Treatment Results in Patients with Sudden Sensorineural Hearing Loss. ⁶²	Rozbicki P...Jurkiewicz D	36294406	2022
38	Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss. ⁶²	Wu Y...Wang J	36258873	2022
39	Vascular loops in cerebellopontine angle in patients with unilateral idiopathic sudden sensorineural hearing loss: Evaluations by three radiological grading systems. ⁶²	Leng Y...Liu B	36258879	2022
40	Idiopathic Sudden Sensorineural Hearing Loss: Is Hyperbaric Oxygen Treatment the Sooner and Longer, the Better? ⁶²	Chin CS...Wu MF	36294791	2022
41	Inflammatory Indicators in Peripheral Blood in Sudden Sensorineural Hearing Loss Patients With Different Shape of Audiograms. ⁶²	Yao Y...She W	36250504	2022
42	Update on Findings about Sudden Sensorineural Hearing Loss and Insight into Its Pathogenesis. ⁶²	Yamada S...Nakanishi H	36362614	2022
43	Combination of Hyperbaric Oxygen Therapy and Oral Steroids for the Treatment of Sudden Sensorineural Hearing Loss: Early or Late? ⁶²	Cavaliere M...Di Stadio A	36295581	2022
44	Injected 3T-3D-FLAIR-MRI labyrinthine patterns match with the severity and tonotopic alteration in sudden sensorineural hearing loss. ⁶²	Compagnone L...Mirafzal S	35286438	2022
45	Better late than never: initial experience of intra-arterial pulsed-urokinase-injection as a salvage therapy for refractory sudden sensorineural hearing loss. ⁶²	Cui Y...Mang J	34726104	2022
46	Salvage intratympanic steroid therapy for sudden sensorineural hearing loss: our real-life experience in 32 patients. ⁶²	Ringrose T...Buckland J	35018883	2022
47	Bilateral sensorineural hearing loss after opioid overdose in an adolescent male. ⁶²	Richard K...Virgin F	36148640	2022
48	Sudden Sensorineural Hearing Loss: A Review. ⁶²	Tripathi P...Deshmukh P	36299969	2022
49	Pretreatment hearing grades and hearing recovery outcomes after primary hyperbaric oxygen treatment in patients with idiopathic sudden sensorineural hearing loss. ⁶²	Vceva A...Sestak A	36100930	2022
50	The effectiveness of hyperbaric oxygen therapy on the final outcome of patients with sudden sensorineural hearing loss. ⁶²	Dova S...Markou K	35952529	2022