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MCID: SDD008
MIFTS: 43

Sudden Sensorineural Hearing Loss

Categories: Ear diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Sudden Sensorineural Hearing Loss

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MalaCards integrated aliases for Sudden Sensorineural Hearing Loss:

Name: Sudden Sensorineural Hearing Loss 52 36
Acute Sensorineural Hearing Loss by Acute Acoustic Trauma or Sudden Deafness or Surgery Induced Acoustic Trauma 52 58
Sudden Deafness 52

Characteristics:

Orphanet epidemiological data:

58
acute sensorineural hearing loss by acute acoustic trauma or sudden deafness or surgery induced acoustic trauma
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Ear diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare otorhinolaryngological diseases


External Ids:

KEGG 36 H01704
ICD10 via Orphanet 33 H83.3
Orphanet 58 ORPHA90059
Sources

Summaries for Sudden Sensorineural Hearing Loss

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KEGG : 36 Sudden sensorineural hearing loss (SNHL) is commonly defined as hearing loss of more than 30 dB, affecting three or more frequencies, arising over less than 3 days. The predominant form of sudden SNHL is unilateral in location, and the main aetiology is idiopathic. As the majority of patients (30-65 %) with unilateral sudden SNHL report spontaneous recovery within 2 weeks, unilateral disease is mostly regarded as a benign condition. Prognosis for recovery is dependent on a number of factors, including patient age, presence of vertigo at onset, degree of hearing loss, and time between onset of hearing loss and treatment. The pathology of sudden SNHL remains unclear. However, a series of factors, including viral infections, microcirculatory disorders, autoimmune disorders, and labyrinthine hemorrhage, have been proposed as causative factors. Different treatment regimens like antioxidants, corticosteroids, vasodilatators, hyperbaric oxygen (HBO), or carbogen therapy have been described. Among these approaches, steroid treatment is the most common.

MalaCards based summary : Sudden Sensorineural Hearing Loss, also known as acute sensorineural hearing loss by acute acoustic trauma or sudden deafness or surgery induced acoustic trauma, is related to venous insufficiency and pericardial effusion. An important gene associated with Sudden Sensorineural Hearing Loss is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and neutrophil, and related phenotypes are Increased shRNA abundance and homeostasis/metabolism

NIH Rare Diseases : 52 Sudden sensorineural deafness is a condition that is characterized by rapid, unexplained hearing loss . More specifically, affected people experience a reduction in hearing of greater than 30 decibels, which may occur all at once or over several days. In most cases, only one ear is affected. People with sudden sensorineural deafness often become dizzy, have ringing in their ears (tinnitus ), or both (40% of the cases). The condition has a variety of causes, including infection, inflammation, tumors , trauma, exposure to toxins and conditions that affect the inner ear such as Meniere's disease . About half of people with sudden sensorineural deafness will recover some or all of their hearing spontaneously and about 85% of those who receive treatment will recover some of their hearing.

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Related Diseases for Sudden Sensorineural Hearing Loss

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Diseases related to Sudden Sensorineural Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 426)
# Related Disease Score Top Affiliating Genes
1 venous insufficiency 30.1 MTHFR F5 F2
2 pericardial effusion 30.0 IL6 F2
3 homocystinuria 29.8 SERPINC1 MTHFR F5
4 mastoiditis 29.8 SERPINC1 MTHFR F2
5 migraine with or without aura 1 29.8 MTHFR IL6 F2 APOH
6 syphilis 29.7 IL6 F2 APOH
7 osteonecrosis 29.7 SERPINC1 MTHFR F2
8 sickle cell anemia 29.7 MTHFR IL6 F2
9 exanthem 29.6 IL6 F2
10 antiphospholipid syndrome 29.5 SERPINC1 MTHFR F5 F2 APOH
11 polyarteritis nodosa 29.5 IL6 APOH
12 pulmonary hypertension 29.4 SERPINC1 IL6 F2
13 homocysteinemia 29.3 SERPINC1 MTHFR F5 F2 APOH
14 endocarditis 29.2 SERPINC1 IL6 F2 APOH
15 arteriosclerosis 29.1 SERPINC1 ITGB3 IL6
16 patent foramen ovale 29.0 SERPINC1 MTHFR F5 F2 APOH
17 thrombophilia due to thrombin defect 28.9 SERPINC1 MTHFR F5 F2 APOH
18 disseminated intravascular coagulation 28.9 SERPINC1 IL6 F5 F2
19 aplastic anemia 28.9 SERPINC1 ITGB3 IL6
20 temporal arteritis 28.7 IL6 APOH
21 eclampsia 28.7 SERPINC1 MTHFR IL6 F2 APOH
22 thrombophilia due to activated protein c resistance 28.7 SERPINC1 MTHFR F5 F2 APOH
23 infective endocarditis 28.6 ITGB3 IL6 F2 APOH
24 stroke, ischemic 28.3 SERPINC1 MTHFR IL6 F5 F2 APOH
25 pre-eclampsia 28.3 SERPINC1 MTHFR IL6 F5 F2 APOH
26 cerebrovascular disease 28.2 MTHFR ITGB3 IL6 F5 F2 APOH
27 central retinal vein occlusion 28.1 SERPINC1 MTHFR IL6 F5 F2 APOH
28 retinal vein occlusion 28.1 SERPINC1 MTHFR IL6 F5 F2 APOH
29 thrombosis 28.0 SERPINC1 MTHFR ITGB3 F5 F2 APOH
30 thrombophilia 28.0 SERPINC1 MTHFR ITGB3 F5 F2 APOH
31 vascular disease 28.0 SERPINC1 MTHFR ITGB3 IL6 F5 F2
32 thrombocytopenia 27.5 SERPINC1 MTHFR ITGB3 IL6 F5 F2
33 myocardial infarction 27.4 SERPINC1 MTHFR ITGB3 IL6 F5 F2
34 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 11.5
35 sensorineural hearing loss 11.5
36 branchiootic syndrome 1 11.0
37 acoustic neuroma 10.7
38 autoimmune disease 10.6
39 neurilemmoma 10.6
40 benign paroxysmal positional nystagmus 10.6
41 pathologic nystagmus 10.6
42 labyrinthitis 10.5
43 lipid metabolism disorder 10.5
44 neuroma 10.5
45 hypercholesterolemia, familial, 1 10.5
46 otitis media 10.5
47 systemic lupus erythematosus 10.4
48 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
49 inner ear disease 10.4
50 herpes simplex 10.4

Graphical network of the top 20 diseases related to Sudden Sensorineural Hearing Loss:



Diseases related to Sudden Sensorineural Hearing Loss
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Symptoms & Phenotypes for Sudden Sensorineural Hearing Loss

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GenomeRNAi Phenotypes related to Sudden Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 F5 ITGB3 MTHFR

MGI Mouse Phenotypes related to Sudden Sensorineural Hearing Loss:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.87 APOH F2 F5 IL6 ITGB3 MTHFR
2 integument MP:0010771 9.65 F2 F5 IL6 ITGB3 MTHFR
3 liver/biliary system MP:0005370 9.55 F5 IL6 ITGB3 MTHFR SERPINC1
4 mortality/aging MP:0010768 9.5 APOH F2 F5 IL6 ITGB3 MTHFR
5 nervous system MP:0003631 9.1 F2 F5 IL6 ITGB3 MTHFR SERPINC1
Sources

Drugs & Therapeutics for Sudden Sensorineural Hearing Loss

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Drugs for Sudden Sensorineural Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Cisplatin Approved Phase 4 15663-27-1 2767 441203 84093
4 Gastrointestinal Agents Phase 4
5 Hormones Phase 4
6 glucocorticoids Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Antiemetics Phase 4
9 Hormone Antagonists Phase 4
10 Anti-Inflammatory Agents Phase 4
11
protease inhibitors Phase 4
12 HIV Protease Inhibitors Phase 4
13 Dexamethasone 21-phosphate Phase 4
14 BB 1101 Phase 4
15 Ginkgo Phase 4
16 Anesthetics Phase 3
17 Ancrod Approved, Investigational Phase 1, Phase 2 9046-56-4
18
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
19 Fibrinolytic Agents Phase 1, Phase 2
20 Pharmaceutical Solutions Phase 1, Phase 2
21 Anticoagulants Phase 1, Phase 2
22 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
23 Antirheumatic Agents Phase 1, Phase 2
24
Prednisolone phosphate Approved, Vet_approved 302-25-0
25
Methylprednisolone Approved, Vet_approved 83-43-2 6741
26
Methylprednisolone hemisuccinate Approved 2921-57-5
27 Prednisolone acetate Approved, Vet_approved 52-21-1
28
Prednisolone Approved, Vet_approved 50-24-8 5755
29
Fludrocortisone Approved, Investigational Early Phase 1 127-31-1 31378
30
Prednisolone hemisuccinate Experimental 2920-86-7
31 Methylprednisolone Acetate
32 Neuroprotective Agents
33 Protective Agents
34 Mineralocorticoids Early Phase 1
35
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone Treatment. Completed NCT01372904 Phase 4 Dexamethasone Phosphate
2 The Effect of Positive Airway Pressure on Idiopathic Sudden Sensorineural Hearing Loss Comorbided With Obstructive Sleep Apnea: A Clinical Randomized Controlled Study Recruiting NCT04192656 Phase 4 Methylprednisolone Hemisuccinate;Ginaton
3 Bed Rest for Idiopathic Sudden Sensorineural Hearing Loss Unknown status NCT00416143 Phase 2, Phase 3 prednisone - oral corticosteroid 1mg/kg/D for 1 week
4 Sudden Hearing Loss Multicenter Treatment Trial Completed NCT00097448 Phase 3 prednisone;methylprednisolone sodium succinate
5 A Prospective, Randomized, Double Blind, Placebo Controlled, Multicenter Study on the Safety and Efficacy of Continuous Infusion of Corticosteroid Delivered Via Catheter in Patients With Idiopathic Sudden Sensorineural Hearing Loss Completed NCT00335920 Phase 3 Dexamethasone-dihydrogenphosphate (4mg/ml)
6 A Phase III Multicenter, Double-blind, Placebo-controlled, Study Evaluating the Safety, and Efficacy of STR001 Treatment in Adults With Sudden Sensorineural Hearing Loss Completed NCT03331627 Phase 3 STR001-IT and STR001-ER
7 Efficacy and Safety of AM-111 in the Treatment of Acute Inner Ear Hearing Loss Completed NCT02561091 Phase 3 AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
8 A Two-part, Randomized, Double-blind, Placebo-controlled, Parallel-group, Efficacy and Safety Study of SENS-401 in Subjects With Severe or Profound Sudden Sensorineural Hearing Loss Recruiting NCT03603314 Phase 2, Phase 3 SENS-401;SENS-401
9 Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment Terminated NCT02809118 Phase 3 AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
10 Double-blind, Randomized, Placebo-controlled Study on Efficacy, Safety and Tolerability of Ancrod in Patients With Sudden Sensorineural Hearing Loss (SSHL) Completed NCT01621256 Phase 1, Phase 2 Ancrod;Saline solution
11 An Open-label Study of the Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
12 A Phase I/II Open-label Study of the Effects of Anakinra in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
13 Efficacy of AM-111 in Patients With Acute Sensorineural Hearing Loss: A Multi-Centre, Double-Blind, Randomised, Placebo-Controlled, Dose-Escalation Phase II Study Completed NCT00802425 Phase 2 AM-111;placebo
14 A Phase 2a, Prospective, Randomized, Double-Blind, Placebo-Controlled, Single and Repeat-Dose, Multicenter, Exploratory Efficacy Study of FX-322 Administered by Intratympanic Injection in Adults With Stable Sensorineural Hearing Loss Recruiting NCT04120116 Phase 2 FX-322;Placebo
15 High Dose Oral Steroids in Sudden Sensorineural Hearing Loss Suspended NCT03255473 Phase 2 Dexamethasone;Prednisone
16 A Phase I & II Open-label Study of the Effects of Anakinra (Kineret) in Corticosteroid-resistant Subjects With Sudden Sensorineural Heaing Loss (SSNHL) Terminated NCT02414152 Phase 1, Phase 2 anakinra
17 INTRATYMPANIC STEROID TREATMENT FOR THE PREVENTION OF INNER EAR TOXICITY ASSOCIATED WITH SYSTEMIC TREATMENT WITH CISPLATIN. Unknown status NCT01285674 Intra-tympanic Cisplatinum
18 Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke Unknown status NCT03431402 Hyperbaric oxygen
19 Glucocorticoid Postauricular Injection Treatment for Sudden Hearing Loss: a Multi-center, Opened, Randomized, Controlled Clinical Trial Unknown status NCT02026479 Dexamethasone Phosphate;Dexamethasone Phosphate;Ginaton
20 Prevalence of Obstructive Sleep Apnea Syndrome in Patients With a History of Sudden Sensorineural Hearing Loss Completed NCT03747874
21 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Completed NCT02309099
22 Clinical Study of Endolymphatic Sac Drainage With or Without Steroids for Intractable Meniere's Disease Completed NCT00500474
23 Effect of Computer-Assisted Speech Training on Speech Recognition and Subjective Benefits for Hearing Aid Users With Severe to Profound Prelingual Hearing Loss Completed NCT02092337
24 Prognosis of Vestibular Dysfunction in Patients With Idiopathic Sudden Sensorineural Hearing Loss Recruiting NCT03951584
25 Markers of Microvascular Lesion in Adult Patients With Acquired Sudden Cochelo-vestibular Deficiency Recruiting NCT03919474
26 Video HIT Results in Sudden Sensorineural Hearing Loss Patients Not yet recruiting NCT04224909
27 Vestibular Prognosis Assessment of the Idiopathic Sudden Sensorineural Hearing Loss With Vestibular Dysfunction Treated With Oral or Intratympanic Glucocorticoids Not yet recruiting NCT03974867 Prednisone 5Mg Tab;Methylprednisolone 40 mg
28 Prospective Study of Sudden Deafness Not yet recruiting NCT04129983
29 The Evaluation of the Ischemia-modified Albumin Levels in the Patients With Sudden Sensorineural Hearing Loss Not yet recruiting NCT03706183
30 Mineralocorticoid Treatment for Sudden Sensorineural Hearing Loss Terminated NCT01186185 Early Phase 1 Fludrocortisone
31 Cochlear Implantation for Treatment of Single-sided Deafness Terminated NCT02532972

Search NIH Clinical Center for Sudden Sensorineural Hearing Loss

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Genetic Tests for Sudden Sensorineural Hearing Loss

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Anatomical Context for Sudden Sensorineural Hearing Loss

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MalaCards organs/tissues related to Sudden Sensorineural Hearing Loss:

40
Testes, Bone, Neutrophil, Endothelial, Brain, Thyroid, Cortex
Sources

Publications for Sudden Sensorineural Hearing Loss

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Articles related to Sudden Sensorineural Hearing Loss:

(show top 50) (show all 1580)
# Title Authors PMID Year
1
Evaluation of Acupuncture's Efficacy Within Otolaryngology. 61
32090591 2020
2
Using corticosteroids to treat sudden sensorineural hearing loss in pregnancy: A case report and literature review. 61
32346519 2020
3
Intratympanic application of triamcinolone in sudden hearing loss-radiologic anatomy in cone beam CT and its' correlation to clinical outcome. 61
32206871 2020
4
Investigation of the prognostic role of neutrophil-to-lymphocyte ratio in Idiopathic Sudden Sensorineural Hearing Loss based on propensity score matching: a retrospective observational study. 61
32170418 2020
5
Silk-coated dexamethasone non-spherical microcrystals for local drug delivery to inner ear. 61
32360767 2020
6
Steroid Nomenclature in Inner Ear Therapy. 61
32195918 2020
7
Frequency-specific efficacy of intratympanic steroid on idiopathic sudden sensorineural hearing loss. 61
32493084 2020
8
Guideline Adherence and Hearing Outcomes of Sudden Sensorineural Hearing Loss in the Military Health System. 61
31912876 2020
9
Could sudden sensorineural hearing loss be the sole manifestation of COVID-19? An investigation into SARS-COV-2 in the etiology of sudden sensorineural hearing loss. 61
32535294 2020
10
Sudden sensorineural hearing loss - A contemporary review of management issues. 61
32440269 2020
11
Clinical course of a critically ill patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 61
32556649 2020
12
Comparison of inner ear drug availability of combined treatment with systemic or local drug injections alone. 61
31278973 2020
13
Potential Confounding Factors May Influence the Association Between Configurations of the Vertebrobasilar System and the Incidence of Idiopathic Sudden Sensorineural Hearing Loss and Canal Paresis. 61
32150021 2020
14
Comparison of Therapeutic Results with/without Additional Hyperbaric Oxygen Therapy in Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Prospective Study. 61
32535600 2020
15
Clinical Characteristics and Prognosis of Sudden Sensorineural Hearing Loss in Post-irradiated Nasopharyngeal Carcinoma Survivors. 61
32558749 2020
16
Magnetic resonance imaging of endolymphatic space in patients with sensorineural hearing loss: comparison between fluctuating and idiopathic sudden sensorineural hearing loss. 61
32027202 2020
17
Machine Learning Models for Predicting Hearing Prognosis in Unilateral Idiopathic Sudden Sensorineural Hearing Loss. 61
32156103 2020
18
Comparisons among vestibular examinations and symptoms of vertigo in sudden sensorineural hearing loss patients. 61
32402694 2020
19
Heparin therapy as adjuvant treatment for profound idiopathic sudden sensorineural hearing loss. 61
31397902 2020
20
Framingham risk score is associated with hearing outcomes in patients with idiopathic sudden sensorineural hearing loss. 61
32425141 2020
21
Clinical implications of posterior semicircular canal function in idiopathic sudden sensorineural hearing loss. 61
32433568 2020
22
Comparison of Steroid Treatment with and without Hyperbaric Oxygen Therapy for Idiopathic Sudden Sensorineural Hearing Loss. 61
32397013 2020
23
The semicircular canal function tests contribute to identifying unilateral idiopathic sudden sensorineural hearing loss with vertigo. 61
32201018 2020
24
Nimodipine and Steroid Combination Therapy for Idiopathic Sudden Sensorineural Hearing Loss. 61
32558748 2020
25
Hyperbaric Oxygen Treatment Improves Hearing Level via Attenuating TLR4/NF-κB Mediated Inflammation in Sudden Sensorineural Hearing Loss Patients. 61
32553077 2020
26
Systemic Immune Inflammatory Index of Patients With Idiopathic Sudden Sensorineural Hearing Loss: Comparison of NLR and PRL Values. 61
32396031 2020
27
Hyperbaric oxygen (HBO) therapy as an effective approach to the treatment of patients with severe idiopathic sudden sensorineural hearing loss. 61
32049552 2020
28
Pregnancy Does Not Increase the Risk of Sudden Sensorineural Hearing Loss: A National Cohort Study. 61
31268583 2020
29
Neutrophil-lymphocyte ratio as a valuable prognostic marker in idiopathic sudden sensorineural hearing loss. 61
31876220 2020
30
Prostaglandin E1 effects on CD62p and PAC-1 in patients with sudden sensorineural hearing loss. 61
32044505 2020
31
Should air travel be avoided shortly after an idiopathic sudden sensorineural hearing loss? 61
32319331 2020
32
Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss. 61
32269282 2020
33
Potential benefits of salvage intratympanic dexamethasone injection in profound idiopathic sudden sensorineural hearing loss. 61
32296977 2020
34
HBO2 for sudden sensorineural hearing loss. 61
32574445 2020
35
Acute sensorineural hearing loss in hemodialysis patients. 61
32306844 2020
36
Serum Renin Levels in Sudden Sensorineural Hearing Loss. 61
32249593 2020
37
Pediatric sudden sensorineural hearing loss: Experience in a pediatric ENT emergency care center. 61
32408010 2020
38
Metabolic syndrome components and sudden sensorineural hearing loss: a case-control study. 61
31980887 2020
39
Impact of Underlying Diagnosis on Speech and Quality of Life Outcomes After Cochlear Implantation for Single-Sided Deafness. 61
32176127 2020
40
Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss. 61
32243585 2020
41
Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss. 61
31714154 2020
42
Dexamethasone eardrop with grommet placement vs intratympanic steroid injection for sudden sensorineural hearing loss: A randomized prospective clinical trial. 61
32487334 2020
43
The role of Yamamoto new scalp acupuncture as an independent treatment for sudden sensorineural hearing loss: a case report. 61
31968987 2020
44
Relationship between the drainage pattern of the dural venous sinuses and hearing recovery in patients with sudden sensorineural hearing loss. 61
32265530 2020
45
The Prognostic Value of Circulating Inflammatory Cell Counts in Sudden Sensorineural Hearing Loss and the Effect of Cardiovascular Risk Factors. 61
32320296 2020
46
Audiological Findings in Patients with Vestibular Migraine and Migraine: History of Migraine May Be a Cause of Low-Tone Sudden Sensorineural Hearing Loss. 61
32200386 2020
47
Metachronous Sudden Sensorineural Hearing Loss: Patient Characteristics and Treatment Outcomes. 61
31986973 2020
48
Is the Risk of Idiopathic Sudden Sensorineural Hearing Loss Higher in Nasopharyngeal Carcinoma than in Hypopharyngeal Cancer? A Population-based study. 61
32221154 2020
49
Effect of Diabetes on the Prognosis of Sudden Sensorineural Hearing Loss: Propensity Score Matching Analysis. 61
31959036 2020
50
Sudden sensorineural hearing loss and bedside phone testing: a guide for primary care. 61
32107247 2020
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Variations for Sudden Sensorineural Hearing Loss

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Expression for Sudden Sensorineural Hearing Loss

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Search GEO for disease gene expression data for Sudden Sensorineural Hearing Loss.
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Pathways for Sudden Sensorineural Hearing Loss

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Pathways related to Sudden Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 12.1 SERPINC1 ITGB3 F5 F2 APOH
2
Folate Metabolism 1
Show member pathways
 11.77 MTHFR IL6 F2
3
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 11.53 SERPINC1 F5 F2
4
Complement and coagulation cascades 36 1
11.29 SERPINC1 F5 F2
5
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 60
11.11 ITGB3 F2
6
Hematopoietic Stem Cell Differentiation 1
11.05 ITGB3 IL6
7
Antifolate resistance 36
10.81 MTHFR IL6
Sources

GO Terms for Sudden Sensorineural Hearing Loss

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Cellular components related to Sudden Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 SERPINC1 IL6 F5 F2 APOH
2 collagen-containing extracellular matrix GO:0062023 9.33 SERPINC1 F2 APOH
3 endoplasmic reticulum lumen GO:0005788 8.92 SERPINC1 IL6 F5 F2

Biological processes related to Sudden Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.7 SERPINC1 IL6 F5
2 platelet degranulation GO:0002576 9.61 ITGB3 F5 APOH
3 acute-phase response GO:0006953 9.51 IL6 F2
4 platelet activation GO:0030168 9.5 ITGB3 IL6 F2
5 positive regulation of JAK-STAT cascade GO:0046427 9.49 IL6 F2
6 blood coagulation, intrinsic pathway GO:0007597 9.48 F2 APOH
7 positive regulation of blood coagulation GO:0030194 9.46 F2 APOH
8 cellular protein metabolic process GO:0044267 9.46 SERPINC1 IL6 F5 F2
9 hemostasis GO:0007599 9.43 SERPINC1 F5 F2
10 negative regulation of fibrinolysis GO:0051918 9.4 F2 APOH
11 negative regulation of lipid storage GO:0010888 9.37 ITGB3 IL6
12 blood coagulation GO:0007596 9.26 SERPINC1 ITGB3 F5 F2
13 regulation of blood coagulation GO:0030193 8.8 SERPINC1 F2 APOH

Molecular functions related to Sudden Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 SERPINC1 F2 APOH
Sources

Sources for Sudden Sensorineural Hearing Loss

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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