MCID: SDD008
MIFTS: 45

Sudden Sensorineural Hearing Loss

Categories: Ear diseases, Rare diseases

Aliases & Classifications for Sudden Sensorineural Hearing Loss

MalaCards integrated aliases for Sudden Sensorineural Hearing Loss:

Name: Sudden Sensorineural Hearing Loss 54 38
Acute Sensorineural Hearing Loss by Acute Acoustic Trauma or Sudden Deafness or Surgery Induced Acoustic Trauma 54 60
Sudden Deafness 54

Characteristics:


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Ear diseases


External Ids:

KEGG 38 H01704
ICD10 via Orphanet 35 H83.3
Orphanet 60 ORPHA90059

Summaries for Sudden Sensorineural Hearing Loss

NIH Rare Diseases : 54 Sudden sensorineural deafness is a condition that is characterized by rapid, unexplained hearing loss. More specifically, affected people experience a reduction in hearing of greater than 30 decibels, which may occur all at once or over several days. In most cases, only one ear is affected. People with sudden sensorineural deafness often become dizzy, have ringing in their ears (tinnitus), or both (40% of the cases). The condition has a variety of causes, including infection, inflammation, tumors, trauma, exposure to toxins and conditions that affect the inner ear such as Ménière's disease. About half of people with sudden sensorineural deafness will recover some or all of their hearing spontaneously and about 85% of those who receive treatment will recover some of their hearing.

MalaCards based summary : Sudden Sensorineural Hearing Loss, also known as acute sensorineural hearing loss by acute acoustic trauma or sudden deafness or surgery induced acoustic trauma, is related to antiphospholipid syndrome and sickle cell anemia. An important gene associated with Sudden Sensorineural Hearing Loss is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Microglia Activation During Neuroinflammation: Microglia Polarization. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and neutrophil, and related phenotypes are Increased shRNA abundance and homeostasis/metabolism

Related Diseases for Sudden Sensorineural Hearing Loss

Diseases related to Sudden Sensorineural Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 antiphospholipid syndrome 29.8 APOH F2 F5 MTHFR
2 sickle cell anemia 29.7 F2 MTHFR
3 endocarditis 29.7 APOH F2 IL6
4 polyarteritis nodosa 29.4 APOH IL6
5 temporal arteritis 29.4 APOH IL6
6 cerebrovascular disease 29.4 F2 F5 IL6 MTHFR
7 myocardial infarction 29.3 F2 F5 IL6 ITGB3 MTHFR
8 patent foramen ovale 29.2 APOH F2 F5 MTHFR
9 infective endocarditis 29.0 APOH F2 IL6 ITGB3
10 central retinal vein occlusion 28.3 APOH F2 F5 IL6 MTHFR
11 retinal vein occlusion 28.3 APOH F2 F5 IL6 MTHFR
12 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 11.5
13 sensorineural hearing loss 11.5
14 acoustic neuroma 10.5
15 meniere disease 10.4
16 vertigo, benign recurrent 10.4
17 benign paroxysmal positional nystagmus 10.4
18 neurilemmoma 10.4
19 lupus erythematosus 10.4
20 multiple sclerosis 10.4
21 systemic lupus erythematosus 10.4
22 pathologic nystagmus 10.4
23 hepatitis 10.3
24 herpes simplex 10.3
25 acute myocardial infarction 10.2
26 diabetes mellitus 10.2
27 neuritis 10.2
28 inferior vena cava interruption 10.2 F5 MTHFR
29 amaurosis fugax 10.2 F5 MTHFR
30 paracetamol poisoning 10.2 F2 F5
31 eclampsia 10.2 F2 MTHFR
32 schizencephaly 10.2 F5 MTHFR
33 sticky platelet syndrome 10.2 F5 ITGB3
34 hemoglobin e disease 10.2 F2 F5
35 sagittal sinus thrombosis 10.2 F2 F5
36 factor viii deficiency 10.2 F2 F5
37 mesenteric vascular occlusion 10.2 F2 MTHFR
38 dysfibrinogenemia 10.2 F2 F5
39 langerhans cell histiocytosis 10.2
40 mumps 10.2
41 chlamydia 10.2
42 lyme disease 10.2
43 impotence 10.2
44 hepatitis c 10.2
45 neuroma 10.2
46 iron metabolism disease 10.2
47 ischemia 10.2
48 histiocytosis 10.2
49 hyperglycemia 10.2
50 sickle cell disease 10.2

Graphical network of the top 20 diseases related to Sudden Sensorineural Hearing Loss:



Diseases related to Sudden Sensorineural Hearing Loss

Symptoms & Phenotypes for Sudden Sensorineural Hearing Loss

GenomeRNAi Phenotypes related to Sudden Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 F5 ITGB3 MTHFR

MGI Mouse Phenotypes related to Sudden Sensorineural Hearing Loss:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 APOH F2 F5 IL6 ITGB3 MTHFR
2 integument MP:0010771 9.55 F2 F5 IL6 ITGB3 MTHFR
3 liver/biliary system MP:0005370 9.26 F5 IL6 ITGB3 MTHFR
4 mortality/aging MP:0010768 9.1 APOH F2 F5 IL6 ITGB3 MTHFR

Drugs & Therapeutics for Sudden Sensorineural Hearing Loss

Drugs for Sudden Sensorineural Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1177-87-3
3
Cisplatin Approved Phase 4 15663-27-1 2767 441203 84093
4
protease inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
5 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
6 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
8 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
9 Dexamethasone 21-phosphate Phase 4,Phase 2,Not Applicable
10 Antiemetics Phase 4,Phase 3,Phase 2,Not Applicable
11 glucocorticoids Phase 4,Phase 2,Phase 3,Not Applicable
12 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
13 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
15 BB 1101 Phase 4,Phase 3,Phase 2,Not Applicable
16 Hormone Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
17 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
18
Prednisone Approved, Vet_approved Phase 2, Phase 3,Phase 3 53-03-2 5865
19
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
20
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
21
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
22
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
23
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
24 Protective Agents Phase 3
25 Methylprednisolone Acetate Phase 3
26 Prednisolone acetate Phase 3
27 Neuroprotective Agents Phase 3
28 Anesthetics Phase 3
29 Ancrod Approved, Investigational Phase 1, Phase 2 9046-56-4
30 Anticoagulants Phase 1, Phase 2
31 Pharmaceutical Solutions Phase 1, Phase 2,Phase 2
32 Fibrinolytic Agents Phase 1, Phase 2
33 Antirheumatic Agents Phase 1, Phase 2,Phase 2
34 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2,Phase 2
35
Fludrocortisone Approved, Investigational Not Applicable 127-31-1 31378
36 Mineralocorticoids Not Applicable
37 Interferon-alpha
38 Immunologic Factors
39 Anti-Infective Agents
40 Antiviral Agents
41 interferons
42
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone Treatment Completed NCT01372904 Phase 4 Dexamethasone Phosphate
2 Bed Rest for Idiopathic Sudden Sensorineural Hearing Loss Unknown status NCT00416143 Phase 2, Phase 3 prednisone - oral corticosteroid 1mg/kg/D for 1 week
3 Sudden Deafness Treatment Trial Completed NCT00097448 Phase 3 prednisone;methylprednisolone sodium succinate
4 Safety and Efficacy of Intratympanic Application of Dexamethasone Via Catheter in Patients With Sudden Hearing Loss Completed NCT00335920 Phase 3 Dexamethasone-dihydrogenphosphate (4mg/ml)
5 AM-111 in the Treatment of Acute Inner Ear Hearing Loss Completed NCT02561091 Phase 3 AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
6 Safety and Efficacy of STR001-IT and STR001-ER in Patients With SSHL Recruiting NCT03331627 Phase 3 STR001-IT and STR001-ER
7 Efficacy of SENS 401 in Subjects With Severe or Profound Sudden Sensorineural Hearing Loss Not yet recruiting NCT03603314 Phase 2, Phase 3 SENS-401;SENS-401
8 Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment Terminated NCT02809118 Phase 3 AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
9 Efficacy, Safety, and Tolerability of Ancrod in Patients With Sudden Hearing Loss Completed NCT01621256 Phase 1, Phase 2 Ancrod;Saline solution
10 The Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
11 Efficacy of AM-111 in Patients With Acute Sensorineural Hearing Loss Completed NCT00802425 Phase 2 AM-111;placebo
12 A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
13 High Dose Oral Steroids in Sudden Sensorineural Hearing Loss Recruiting NCT03255473 Phase 2 Dexamethasone;Prednisone
14 Study of the Effects of Anakinra in Corticosteroid-resistant Subjects With Sudden Sensorineural Hearing Loss Terminated NCT02414152 Phase 1, Phase 2 anakinra
15 Fludrocortisone for Sudden Hearing Loss Unknown status NCT01186185 Not Applicable Fludrocortisone
16 Sudden Hearing Loss Multi-center Clinical Trial Unknown status NCT02026479 Not Applicable Dexamethasone Phosphate;Dexamethasone Phosphate;Ginaton
17 The Effect of Antiviral Therapy With Pegylated Interferon-alpha on Auditory Disability Completed NCT01265693
18 Prognosis of Vestibular Dysfunction in Patients With Idiopathic Sudden Sensorineural Hearing Loss Recruiting NCT03951584
19 Blood Markers in Adult Patients With Sudden Sensorineural Hearing Loss (SSNHL) Recruiting NCT03919474
20 Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke Recruiting NCT03431402 Not Applicable Hyperbaric oxygen
21 OSA and Sudden Sensorineural Hearing Loss Enrolling by invitation NCT03747874 Not Applicable
22 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650
23 Ischemia- Modified Albumin Levels in the Sudden Hearing Loss Not yet recruiting NCT03706183

Search NIH Clinical Center for Sudden Sensorineural Hearing Loss

Genetic Tests for Sudden Sensorineural Hearing Loss

Anatomical Context for Sudden Sensorineural Hearing Loss

MalaCards organs/tissues related to Sudden Sensorineural Hearing Loss:

42
Bone, Endothelial, Neutrophil, Heart, Testes, Brain, Kidney

Publications for Sudden Sensorineural Hearing Loss

Articles related to Sudden Sensorineural Hearing Loss:

(show top 50) (show all 899)
# Title Authors Year
1
Metformin decreases the risk of sudden sensorineural hearing loss in patients with diabetes mellitus: A 14-year follow-up study. ( 30712377 )
2019
2
Primary Ewing sarcoma of the squamous temporal bone with intracranial and extracranial extension: A rare cause of sudden sensorineural hearing loss. ( 30584673 )
2019
3
Improvement or Recovery From Sudden Sensorineural Hearing Loss With Steroid Therapy Does Not Preclude the Need for MRI to Rule Out Vestibular Schwannoma. ( 30807520 )
2019
4
Sudden Sensorineural Hearing Loss in Children: Clinical Characteristics, Etiology, Treatment Outcomes, and Prognostic Factors. ( 30870353 )
2019
5
Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review. ( 30870848 )
2019
6
The atherogenic index (ATH index) as a potential predictive marker of idiopathic sudden sensorineural hearing loss: a case control study. ( 30876416 )
2019
7
Markers of Oxidant-Antioxidant Equilibrium in Patients with Sudden Sensorineural Hearing Loss Treated with Hyperbaric Oxygen Therapy. ( 30881599 )
2019
8
The Natural History of Labyrinthine Hemorrhage in Patients With Sudden Sensorineural Hearing Loss. ( 30909739 )
2019
9
Extensive Heterogeneity in the Meta-analysis of Hyperbaric Oxygen Therapy for Idiopathic Sudden Sensorineural Hearing Loss-Reply. ( 30920594 )
2019
10
Extensive Heterogeneity in the Meta-analysis of Hyperbaric Oxygen Therapy for Idiopathic Sudden Sensorineural Hearing Loss. ( 30920600 )
2019
11
Efficacy and Prognostic Factors of Combined Hyperbaric Oxygen Therapy in Patients With Idiopathic Sudden Sensorineural Hearing Loss. ( 30938564 )
2019
12
Effects of meteorological factor and air pollution on sudden sensorineural hearing loss using the health claims data in Busan, Republic of Korea. ( 30956004 )
2019
13
Hormone therapy is not associated with the risk of sudden sensorineural hearing loss in postmenopausal women: a 10-year nationwide population-based study. ( 30969183 )
2019
14
Response of Glucocorticoid Receptor Alpha and Histone Deacetylase 2 to Glucocorticoid Treatment Predicts the Prognosis of Sudden Sensorineural Hearing Loss. ( 30993958 )
2019
15
Efficacy of intratympanic corticosteroid, intravenous batroxobin and combined treatment for sudden sensorineural hearing loss with type-2 diabetes. ( 31008670 )
2019
16
Efficacy of Intratympanic Steroid on Idiopathic Sudden Sensorineural Hearing Loss: An Analysis of Cases With Negative Prognostic Factors. ( 31046392 )
2019
17
Different prognoses in patients with profound sudden sensorineural hearing loss. ( 31050574 )
2019
18
Investigation of Stress Levels before the Onset of Idiopathic Sudden Sensorineural Hearing Loss. ( 31058595 )
2019
19
Long-term Audiometric Outcomes in Unilateral Sudden Sensorineural Hearing Loss without Recurrence. ( 31058596 )
2019
20
White matter lesions and sudden sensorineural hearing loss. ( 31072738 )
2019
21
An unusual case of sudden sensorineural hearing loss after cycling class. ( 31079847 )
2019
22
Improvement or Recovery From Sudden Sensorineural Hearing Loss With Steroid Therapy Does Not Preclude the Need for MRI to Rule Out Vestibular Schwannoma. ( 31083098 )
2019
23
Recovery From Sudden Sensorineural Hearing Loss May Be Linked to Chronic Stress Levels and Steroid Treatment Resistance. ( 31084569 )
2019
24
Right-to-left shunt and idiopathic sudden sensorineural hearing loss. ( 31097828 )
2019
25
Impact of metabolic syndrome on recovery of idiopathic sudden sensorineural hearing loss. ( 31109803 )
2019
26
Patient education in sudden sensorineural hearing loss: Knowledge, attitude/belief, and practice findings among otolaryngologists and otologists in China. ( 30146406 )
2019
27
Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Sudden Sensorineural Hearing Loss. ( 30326473 )
2019
28
Migraine increases the proportion of sudden sensorineural hearing loss: A longitudinal follow-up study. ( 30389313 )
2019
29
MR evaluation of encephalic leukoaraiosis in sudden sensorineural hearing loss (SSNHL) patients. ( 30465101 )
2019
30
Audiological outcomes in sudden sensorineural hearing loss with presumed inner ear hemorrhage. ( 30473168 )
2019
31
MTHFR AND ApoE genetic variants association with sudden sensorineural hearing loss. ( 30477909 )
2019
32
Intratympanic Dexamethasone via Saturated Gelfoam for Idiopathic Sudden Sensorineural Hearing Loss. ( 30511891 )
2019
33
Time and geographic clustering of adult patients with unilateral idiopathic sudden sensorineural hearing loss. ( 30593408 )
2019
34
Hearing Outcome of Low-tone Compared to High-tone Sudden Sensorineural Hearing Loss. ( 30647786 )
2019
35
Sudden sensorineural hearing loss during pregnancy: clinical characteristics, management and outcome. ( 30664387 )
2019
36
Acupuncture for the treatment of sudden sensorineural hearing loss: A systematic review and meta-analysis: Acupuncture for SSNHL. ( 30670271 )
2019
37
Inflammatory cytokines and mononuclear cells in sudden sensorineural hearing loss. ( 30739608 )
2019
38
Post-contrast 3D-FLAIR in idiopathic sudden sensorineural hearing loss. ( 30747317 )
2019
39
Efficacy of combination therapy in adolescent and adult patients with total-deafness sudden sensorineural hearing loss. ( 30762471 )
2019
40
Intratympanic Steroid Use for Sudden Sensorineural Hearing Loss: Current Otolaryngology Practice. ( 30770021 )
2019
41
Nationwide Survey of Intratympanic Steroids for the Management of Sudden Sensorineural Hearing Loss. ( 30772961 )
2019
42
Predictive values of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and other prognostic factors in pediatric idiopathic sudden sensorineural hearing loss. ( 30784810 )
2019
43
Sudden sensorineural hearing loss in adults. ( 30787010 )
2019
44
The prevalence of vestibular schwannoma among patients treated as sudden sensorineural hearing loss. ( 30042019 )
2019
45
Trough-Shaped Audiograms Are Common in Patients with Acoustic Neuroma and Sudden Sensorineural Hearing Loss. ( 30021194 )
2018
46
Idiopathic Sudden Sensorineural Hearing Loss Is Not a Sentinel Event for Acute Myocardial Infarction. ( 29912831 )
2018
47
Bilateral sudden sensorineural hearing loss as a first symptom of infective endocarditis: two case reports. ( 29463328 )
2018
48
Risk of developing sudden sensorineural hearing loss in patients with hepatitis B virus infection: A population-based study. ( 30481851 )
2018
49
Can A Sudden Sensorineural Hearing Loss Occur Due to Miliary Tuberculosis? ( 29036759 )
2018
50
Anti-mumps IgM antibody positive rate with sudden sensorineural hearing loss using second-generation enzyme immunoassay: A retrospective, multi-institutional investigation in Hokkaido, Japan. ( 29224848 )
2018

Variations for Sudden Sensorineural Hearing Loss

Expression for Sudden Sensorineural Hearing Loss

Search GEO for disease gene expression data for Sudden Sensorineural Hearing Loss.

Pathways for Sudden Sensorineural Hearing Loss

GO Terms for Sudden Sensorineural Hearing Loss

Cellular components related to Sudden Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.8 F2 F5 IL6

Biological processes related to Sudden Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.63 F2 F5 IL6
2 blood coagulation GO:0007596 9.61 F2 F5 ITGB3
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.54 IL6 ITGB3
4 hemostasis GO:0007599 9.52 F2 F5
5 blood circulation GO:0008015 9.51 F5 MTHFR
6 acute-phase response GO:0006953 9.49 F2 IL6
7 positive regulation of JAK-STAT cascade GO:0046427 9.48 F2 IL6
8 blood coagulation, intrinsic pathway GO:0007597 9.4 APOH F2
9 positive regulation of blood coagulation GO:0030194 9.37 APOH F2
10 platelet degranulation GO:0002576 9.33 APOH F5 ITGB3
11 regulation of blood coagulation GO:0030193 9.32 APOH F2
12 negative regulation of fibrinolysis GO:0051918 9.26 APOH F2
13 negative regulation of lipid storage GO:0010888 8.96 IL6 ITGB3
14 platelet activation GO:0030168 8.8 F2 IL6 ITGB3

Sources for Sudden Sensorineural Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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