MCID: SDD008
MIFTS: 45

Sudden Sensorineural Hearing Loss

Categories: Rare diseases, Ear diseases

Aliases & Classifications for Sudden Sensorineural Hearing Loss

MalaCards integrated aliases for Sudden Sensorineural Hearing Loss:

Name: Sudden Sensorineural Hearing Loss 53 37
Acute Sensorineural Hearing Loss by Acute Acoustic Trauma or Sudden Deafness or Surgery Induced Acoustic Trauma 53 59
Sudden Deafness 53

Characteristics:


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Ear diseases


External Ids:

Orphanet 59 ORPHA90059
ICD10 via Orphanet 34 H83.3
KEGG 37 H01704

Summaries for Sudden Sensorineural Hearing Loss

NIH Rare Diseases : 53 Sudden sensorineural deafness is a condition that is characterized by rapid, unexplained hearing loss. More specifically, affected people experience a reduction in hearing of greater than 30 decibels, which may occur all at once or over several days. In most cases, only one ear is affected. People with sudden sensorineural deafness often become dizzy, have ringing in their ears (tinnitus), or both (40% of the cases). The condition has a variety of causes, including infection, inflammation, tumors, trauma, exposure to toxins and conditions that affect the inner ear such as Ménière's disease. About half of people with sudden sensorineural deafness will recover some or all of their hearing spontaneously and about 85% of those who receive treatment will recover some of their hearing.

MalaCards based summary : Sudden Sensorineural Hearing Loss, also known as acute sensorineural hearing loss by acute acoustic trauma or sudden deafness or surgery induced acoustic trauma, is related to varicose veins and antiphospholipid syndrome. An important gene associated with Sudden Sensorineural Hearing Loss is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Dexamethasone and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and bone, and related phenotypes are Increased shRNA abundance and homeostasis/metabolism

Related Diseases for Sudden Sensorineural Hearing Loss

Diseases related to Sudden Sensorineural Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 varicose veins 28.6 F2 F5 MTHFR SERPINC1
2 antiphospholipid syndrome 28.6 F2 F5 MTHFR SERPINC1
3 cerebrovascular disease 28.3 F2 F5 IL6 MTHFR
4 myocardial infarction 26.6 F2 F5 IL6 ITGB3 MTHFR SERPINC1
5 sensorineural hearing loss 11.2
6 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 11.2
7 inferior vena cava interruption 10.5 F5 MTHFR
8 amaurosis fugax 10.5 F5 MTHFR
9 catastrophic antiphospholipid syndrome 10.5 F5 MTHFR
10 paracetamol poisoning 10.4 F2 F5
11 cerebral sinovenous thrombosis 10.4 F2 F5
12 hemoglobin e disease 10.4 F2 F5
13 factor viii deficiency 10.4 F2 F5
14 mesenteric vascular occlusion 10.4 F2 MTHFR
15 schizencephaly 10.3 F5 MTHFR
16 ischemic neuropathy 10.3 F2 MTHFR
17 scott syndrome 10.3 F2 F5
18 acute liver failure 10.3 F2 F5
19 severe hemophilia a 10.3 F2 F5
20 buerger disease 10.3 F2 MTHFR
21 endotheliitis 10.2
22 benign paroxysmal positional nystagmus 10.2
23 vertigo, benign recurrent 10.2
24 afibrinogenemia 10.2 F2 F5
25 meningococcemia 10.2 F5 SERPINC1
26 von willebrand's disease 10.2 F2 F5
27 legg-calve-perthes disease 10.2 F5 SERPINC1
28 factor xii deficiency 10.2 F5 SERPINC1
29 factor v deficiency 10.2 F2 F5
30 nutritional deficiency disease 10.2 F2 MTHFR
31 intestinal impaction 10.2 F2 SERPINC1
32 fournier gangrene 10.1 F2 SERPINC1
33 leech infestation 10.1 F2 SERPINC1
34 alpha-2-plasmin inhibitor deficiency 10.1 F2 SERPINC1
35 lupus erythematosus 10.1
36 multiple sclerosis 10.1
37 acute myocardial infarction 10.1
38 labyrinthitis 10.1
39 giant hemangioma 10.1 F2 SERPINC1
40 blue toe syndrome 10.1 F2 SERPINC1
41 intracranial embolism 10.1 F2 SERPINC1
42 anterior spinal artery syndrome 10.1 F2 SERPINC1
43 subendocardial myocardial infarction 10.1 F2 SERPINC1
44 purpura fulminans 10.1 F2 SERPINC1
45 korean hemorrhagic fever 10.1 F2 SERPINC1
46 esophageal varix 10.1 F2 SERPINC1
47 hypersplenism 10.1 F2 SERPINC1
48 coronary thrombosis 10.1 ITGB3 SERPINC1
49 factor xi deficiency 10.1 F2 SERPINC1
50 auditory system disease 10.1

Graphical network of the top 20 diseases related to Sudden Sensorineural Hearing Loss:



Diseases related to Sudden Sensorineural Hearing Loss

Symptoms & Phenotypes for Sudden Sensorineural Hearing Loss

GenomeRNAi Phenotypes related to Sudden Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 MTHFR F5 ITGB3

MGI Mouse Phenotypes related to Sudden Sensorineural Hearing Loss:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.85 F2 F5 IL6 ITGB3 MTHFR SERPINC1
2 cardiovascular system MP:0005385 9.8 ITGB3 SERPINC1 F2 F5 IL6
3 integument MP:0010771 9.72 F2 F5 IL6 ITGB3 MTHFR
4 mortality/aging MP:0010768 9.63 F2 F5 IL6 ITGB3 MTHFR SERPINC1
5 liver/biliary system MP:0005370 9.56 F5 IL6 ITGB3 SERPINC1
6 nervous system MP:0003631 9.43 IL6 ITGB3 MTHFR SERPINC1 F2 F5
7 reproductive system MP:0005389 9.02 F2 IL6 ITGB3 MTHFR SERPINC1

Drugs & Therapeutics for Sudden Sensorineural Hearing Loss

Drugs for Sudden Sensorineural Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-02-2 5743
2
Cisplatin Approved Phase 4 15663-27-1 84093 441203 2767
3 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Not Applicable 1177-87-3
4 glucocorticoids Phase 4,Phase 2,Phase 3,Not Applicable
5
protease inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
6 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
7 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
8 Hormone Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
9 Dexamethasone 21-phosphate Phase 4,Phase 2,Not Applicable
10 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
12 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Antiemetics Phase 4,Phase 3,Phase 2,Not Applicable
14 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
15 BB 1101 Phase 4,Phase 3,Phase 2,Not Applicable
16 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
17 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
18
Prednisone Approved, Vet_approved Phase 2, Phase 3,Phase 3 53-03-2 5865
19
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
20
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
21 Prednisolone acetate Phase 3
22 Methylprednisolone acetate Phase 3
23 Methylprednisolone Hemisuccinate Phase 3
24 Neuroprotective Agents Phase 3
25 Prednisolone hemisuccinate Phase 3
26 Prednisolone phosphate Phase 3
27 Protective Agents Phase 3
28 Anesthetics Phase 3
29 Ancrod Approved, Investigational Phase 1, Phase 2 9046-56-4
30 Pharmaceutical Solutions Phase 2,Phase 1
31 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2,Phase 2
32 Antirheumatic Agents Phase 1, Phase 2,Phase 2
33 Fibrinolytic Agents Phase 1, Phase 2
34 Anticoagulants Phase 1, Phase 2
35
Fludrocortisone Approved, Investigational Not Applicable 127-31-1 31378
36 Mineralocorticoids Not Applicable
37 interferons
38 Anti-Infective Agents
39 Interferon-alpha
40 Antiviral Agents

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone Treatment Completed NCT01372904 Phase 4 Dexamethasone Phosphate
2 Bed Rest for Idiopathic Sudden Sensorineural Hearing Loss Unknown status NCT00416143 Phase 2, Phase 3 prednisone - oral corticosteroid 1mg/kg/D for 1 week
3 Sudden Deafness Treatment Trial Completed NCT00097448 Phase 3 prednisone;methylprednisolone sodium succinate
4 Safety and Efficacy of Intratympanic Application of Dexamethasone Via Catheter in Patients With Sudden Hearing Loss Completed NCT00335920 Phase 3 Dexamethasone-dihydrogenphosphate (4mg/ml)
5 AM-111 in the Treatment of Acute Inner Ear Hearing Loss Completed NCT02561091 Phase 3 AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
6 Safety and Efficacy of STR001-IT and STR001-ER in Patients With SSHL Not yet recruiting NCT03331627 Phase 3 STR001-IT and STR001-ER
7 Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment Terminated NCT02809118 Phase 3 AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
8 The Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
9 Efficacy of AM-111 in Patients With Acute Sensorineural Hearing Loss Completed NCT00802425 Phase 2 AM-111;placebo
10 A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
11 High Dose Oral Steroids in Sudden Sensorineural Hearing Loss Recruiting NCT03255473 Phase 2 Dexamethasone;Prednisone
12 Efficacy, Safety, and Tolerability of Ancrod in Patients With Sudden Hearing Loss Recruiting NCT01621256 Phase 1, Phase 2 Ancrod;Saline solution
13 Study of the Effects of Anakinra in Corticosteroid-resistant Subjects With Sudden Sensorineural Hearing Loss Terminated NCT02414152 Phase 1, Phase 2 anakinra
14 Fludrocortisone for Sudden Hearing Loss Unknown status NCT01186185 Not Applicable Fludrocortisone
15 Sudden Hearing Loss Multi-center Clinical Trial Unknown status NCT02026479 Not Applicable Dexamethasone Phosphate;Dexamethasone Phosphate;Ginaton
16 The Effect of Antiviral Therapy With Pegylated Interferon-alpha on Auditory Disability Completed NCT01265693
17 Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke Recruiting NCT03431402 Not Applicable Hyperbaric oxygen
18 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650

Search NIH Clinical Center for Sudden Sensorineural Hearing Loss

Genetic Tests for Sudden Sensorineural Hearing Loss

Anatomical Context for Sudden Sensorineural Hearing Loss

MalaCards organs/tissues related to Sudden Sensorineural Hearing Loss:

41
Testes, Endothelial, Bone, Neutrophil, Brain, Heart, Myeloid

Publications for Sudden Sensorineural Hearing Loss

Articles related to Sudden Sensorineural Hearing Loss:

(show top 50) (show all 389)
# Title Authors Year
1
Prognostic factors regarding the hearing outcome in severe to profound sudden sensorineural hearing loss treated by tympanotomy and sealing of labyrinthine windows after ineffective systemic corticosteroid application. ( 29855690 )
2018
2
Association of Sudden Sensorineural Hearing Loss With Risk of Cardiocerebrovascular Disease: A Study Using Data From the Korea National Health Insurance Service. ( 29270613 )
2018
3
Mobile Hearing Testing Applications and the Diagnosis of Sudden Sensorineural Hearing Loss: A Cautionary Tale. ( 29227445 )
2018
4
Hypertrophic Pachymeningitis of the Internal Auditory Canal: A Rare Case of Unilateral Sudden Sensorineural Hearing Loss. ( 29938521 )
2018
5
Assessment of Spontaneous Recovery Rates in Patients With Idiopathic Sudden Sensorineural Hearing Loss. ( 29931029 )
2018
6
Comparison of intratympanic dexamethasone therapy and hyperbaric oxygen therapy for the salvage treatment of refractory high-frequency sudden sensorineural hearing loss. ( 29891394 )
2018
7
Efficacy of systemic and intratympanic corticosteroid combination therapy versus intratympanic or systemic therapy in patients with idiopathic sudden sensorineural hearing loss: a randomized controlled trial. ( 29149379 )
2018
8
Oral and intratympanic steroid therapy for idiopathic sudden sensorineural hearing loss. ( 29721537 )
2018
9
The role of explorative tympanotomy in patients with sudden sensorineural hearing loss with and without perilymphatic fistula. ( 29055686 )
2018
10
A protocol for a network meta-analysis of interventions to treat patients with sudden sensorineural hearing loss. ( 29769117 )
2018
11
Delayed Recovery in Pediatric Sudden Sensorineural Hearing Loss Predicted via Magnetic Resonance Imaging. ( 29717656 )
2018
12
Inpatient treatment of patients with idiopathic sudden sensorineural hearing loss: a population-based healthcare research study. ( 29330597 )
2018
13
Association of Vertigo With Hearing Outcomes in Patients With Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. ( 29931169 )
2018
14
Idiopathic Sudden Sensorineural Hearing Loss Is Not a Sentinel Event for Acute Myocardial Infarction. ( 29912831 )
2018
15
Prognostic role of haematological indices in sudden sensorineural hearing loss: Review and meta-analysis. ( 29684383 )
2018
16
Can A Sudden Sensorineural Hearing Loss Occur Due to Miliary Tuberculosis? ( 29036759 )
2018
17
Comparison of 2 and 4 Intratympanic Steroid Injections in the Treatment of Idiopathic Sudden Sensorineural Hearing Loss. ( 29411622 )
2018
18
Association of Idiopathic Sudden Sensorineural Hearing Loss With Affective Disorders. ( 29852049 )
2018
19
The Clinical Value of Vertigo as a Prognostic Indicator of Outcome in Sudden Sensorineural Hearing Loss. ( 29931206 )
2018
20
Mobile phone usage does not affect sudden sensorineural hearing loss. ( 29179790 )
2018
21
Association of Metabolic Syndrome With Sudden Sensorineural Hearing Loss. ( 29450496 )
2018
22
Coexistence of IL-6 -572C/G and ICAM-1 K469E Polymorphisms among Patients with Sudden Sensorineural Hearing Loss. ( 29695657 )
2018
23
The Characteristic and Short-Term Prognosis of Tinnitus Associated with Sudden Sensorineural Hearing Loss. ( 29861716 )
2018
24
Modified Siegel's criteria for sudden sensorineural hearing loss: Reporting recovery outcomes with matched pretreatment hearing grades. ( 29929833 )
2018
25
Effect of Antioxidant Vitamins as Adjuvant Therapy for Sudden Sensorineural Hearing Loss: Systematic Review Study. ( 29929192 )
2018
26
Sudden Sensorineural Hearing Loss in the Department of Defense. ( 29631507 )
2018
27
Acupuncture as an early treatment for idiopathic sudden sensorineural hearing loss (ISSNHL) patients with flat or high-frequency drop audiograms: study protocol for a randomized controlled trial. ( 29973265 )
2018
28
Is nucleate cell count and neutrophil to lymphocyte ratio related to patients with audiographically distinct sudden sensorineural hearing loss? ( 29768325 )
2018
29
Comparison between Bilateral and Unilateral Sudden Sensorineural Hearing Loss. ( 29363646 )
2018
30
Letter to the Editor Regarding Comparison of 2 and 4 Intratympanic Steroid Injections in the Treatment of Idiopathic Sudden Sensorineural Hearing Loss by Suzuki et al. ( 29911911 )
2018
31
Does the addition of hyperbaric oxygen therapy to conventional treatment modalities influence the outcome of soldiers with idiopathic sudden sensorineural hearing loss? ( 29431146 )
2018
32
International consensus (ICON) on treatment of sudden sensorineural hearing loss. ( 29396226 )
2018
33
Predicting the hearing outcome in sudden sensorineural hearing loss via machine learning models. ( 29356346 )
2018
34
Hyperbaric Oxygen Therapy as Adjuvant Treatment for Idiopathic Sudden Sensorineural Hearing Loss after Failure of Systemic Steroids. ( 28423374 )
2017
35
Prognosticating hearing outcome in patients with idiopathic sudden sensorineural hearing loss by means of otoacoustic emissions and auditory brainstem response. ( 29236273 )
2017
36
A honey bee can threat ear: Sudden sensorineural hearing loss. ( 28818308 )
2017
37
Idiopathic sudden sensorineural hearing loss and mAcniA"re syndrome: The role of cerebral venous drainage. ( 28744995 )
2017
38
Early cortical metabolic rearrangement related to clinical data in idiopathic sudden sensorineural hearing loss. ( 28460253 )
2017
39
Differences in platelet-related parameters among patients with audiographically distinct sudden sensorineural hearing loss: A retrospective study. ( 28885341 )
2017
40
Factors Prognostic of Season-Associated Sudden Sensorineural Hearing Loss: A Retrospective Observational Study. ( 28417108 )
2017
41
Use of Vasodilators In Idiopathic Sudden Sensorineural Hearing Loss: A Systematic Review. ( 29283102 )
2017
42
Early identification of idiopathic sudden sensorineural hearing loss. ( 28787350 )
2017
43
Sealing of the round and oval window niches with triamcinolone-soaked fascia as salvage surgical therapy in sudden sensorineural hearing loss. ( 28415914 )
2017
44
Aminophylline restores glucocorticoid sensitivity in a guinea pig model of sudden sensorineural hearing loss induced by lipopolysaccharide. ( 28578424 )
2017
45
Questionnaires in Patients with Unilateral Sudden Sensorineural Hearing Loss. ( 28816692 )
2017
46
Assessment of balance and vestibular functions in patients with idiopathic sudden sensorineural hearing loss. ( 28397037 )
2017
47
Adjunctive hyperbaric oxygen treatment for idiopathic sudden sensorineural hearing loss. ( 28768087 )
2017
48
Identification of evidence for autoimmune pathology of bilateral sudden sensorineural hearing loss using proteomic analysis. ( 28648633 )
2017
49
Framingham Risk Score as a Prognostic Predictor of Sudden Sensorineural Hearing Loss: A Preliminary Study. ( 28397567 )
2017
50
Erythrocyte Membrane Fluidity Alterations in Sudden Sensorineural Hearing Loss Patients: The Role of Oxidative Stress. ( 29212121 )
2017

Variations for Sudden Sensorineural Hearing Loss

Expression for Sudden Sensorineural Hearing Loss

Search GEO for disease gene expression data for Sudden Sensorineural Hearing Loss.

Pathways for Sudden Sensorineural Hearing Loss

GO Terms for Sudden Sensorineural Hearing Loss

Cellular components related to Sudden Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.92 F2 F5 IL6 SERPINC1

Biological processes related to Sudden Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.65 F5 IL6 SERPINC1
2 platelet activation GO:0030168 9.5 F2 IL6 ITGB3
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.49 IL6 ITGB3
4 blood circulation GO:0008015 9.46 F5 MTHFR
5 acute-phase response GO:0006953 9.43 F2 IL6
6 positive regulation of JAK-STAT cascade GO:0046427 9.4 F2 IL6
7 regulation of blood coagulation GO:0030193 9.37 F2 SERPINC1
8 hemostasis GO:0007599 9.33 F2 F5 SERPINC1
9 negative regulation of lipid storage GO:0010888 9.26 IL6 ITGB3
10 cellular protein metabolic process GO:0044267 9.26 F2 F5 IL6 SERPINC1
11 blood coagulation GO:0007596 8.92 F2 F5 ITGB3 SERPINC1

Sources for Sudden Sensorineural Hearing Loss

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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44 MeSH
45 MESH via Orphanet
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54 NINDS
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
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74 UMLS via Orphanet
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