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MCID: SLF017
MIFTS: 28

Sulfamethoxazole Allergy

Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Sulfamethoxazole Allergy

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MalaCards integrated aliases for Sulfamethoxazole Allergy:

Name: Sulfamethoxazole Allergy 12 15
Sulphamethoxazole Allergy 12
Smx Allergy 12
Smz Allergy 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0040016
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Summaries for Sulfamethoxazole Allergy

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Disease Ontology : 12 A drug allergy that has allergic trigger sulfamethoxazole.

MalaCards based summary : Sulfamethoxazole Allergy, also known as sulphamethoxazole allergy, is related to co-trimoxazole allergy and penicilliosis. An important gene associated with Sulfamethoxazole Allergy is CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include t cells, and related phenotypes are endocrine/exocrine gland and hematopoietic system

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Related Diseases for Sulfamethoxazole Allergy

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Diseases related to Sulfamethoxazole Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 co-trimoxazole allergy 11.5
2 penicilliosis 10.4 CD86 CD40
3 acute myocarditis 10.3 CD86 CD40
4 common wart 10.3 CD80 CD40
5 plague 10.3 CD86 CD83
6 type 1 diabetes mellitus 13 10.3 CD86 CD80
7 type 1 diabetes mellitus 6 10.3 CD86 CD80
8 myositis fibrosa 10.3 CD86 CD80
9 spondylarthropathy 10.2 CD80 CD40
10 immunodeficiency with hyper-igm, type 1 10.2 IL4 CD40
11 autoimmune peripheral neuropathy 10.2 CD86 CD80
12 anterior scleritis 10.1 MPO IL5
13 nickel allergic contact dermatitis 10.1 IL5 IL4
14 cough variant asthma 10.1 IL5 IL4
15 egg allergy 10.1 IL5 IL4
16 scleritis 10.1 IL5 IL4
17 atopic keratoconjunctivitis 10.1 IL5 IL4
18 inflammatory bowel disease 4 10.1 IL5 IL4
19 trichinosis 10.1 IL5 IL4
20 intrinsic asthma 10.1 IL5 IL4
21 angiostrongyliasis 10.1 IL5 IL4
22 apple allergy 10.1 IL5 IL4
23 churg-strauss syndrome 10.1 MPO IL5
24 gaucher disease, type ii 10.1 IL5 IL4
25 non-suppurative otitis media 10.1 IL5 IL4
26 eosinophilic meningitis 10.1 IL5 IL4
27 latex allergy 10.0 IL5 IL4
28 eosinophilic gastritis 10.0 IL5 IL4
29 chronic conjunctivitis 10.0 IL5 IL4
30 filarial elephantiasis 10.0 IL5 IL4
31 chronic tic disorder 10.0 IL5 IL4
32 intestinal schistosomiasis 10.0 IL5 IL4
33 kimura disease 10.0 IL5 IL4
34 transient hypogammaglobulinemia of infancy 10.0 IL4 CD40
35 toxic oil syndrome 10.0 IL5 IL4
36 vernal keratoconjunctivitis 10.0 IL5 IL4
37 urinary schistosomiasis 10.0 IL5 IL4
38 folliculitis 10.0 IL5 IL4
39 proliferative glomerulonephritis 10.0 MPO IL4
40 enterobiasis 10.0 IL5 IL4
41 conjunctival disease 10.0 IL5 IL4
42 milk allergy 10.0 IL5 IL4
43 vernal conjunctivitis 10.0 MPO IL4
44 allergic bronchopulmonary aspergillosis 9.9 IL5 IL4
45 pulmonary eosinophilia 9.9 IL5 IL4
46 paranasal sinus disease 9.9 IL5 IL4
47 onchocerciasis 9.8 IL5 IL4
48 nasal cavity disease 9.8 IL5 IL4
49 allergic conjunctivitis 9.8 IL5 IL4
50 yellow fever 9.8 IL5 IL4

Graphical network of the top 20 diseases related to Sulfamethoxazole Allergy:



Diseases related to Sulfamethoxazole Allergy
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Symptoms & Phenotypes for Sulfamethoxazole Allergy

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MGI Mouse Phenotypes related to Sulfamethoxazole Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 CD4 CD40 CD80 CD83 CD86 IL4
2 hematopoietic system MP:0005397 9.56 CD4 CD40 CD80 CD83 CD86 IL4
3 immune system MP:0005387 9.23 CD4 CD40 CD80 CD83 CD86 IL4
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Drugs & Therapeutics for Sulfamethoxazole Allergy

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Search Clinical Trials , NIH Clinical Center for Sulfamethoxazole Allergy

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Genetic Tests for Sulfamethoxazole Allergy

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Anatomical Context for Sulfamethoxazole Allergy

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MalaCards organs/tissues related to Sulfamethoxazole Allergy:

41
T Cells
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Publications for Sulfamethoxazole Allergy

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Articles related to Sulfamethoxazole Allergy:

# Title Authors PMID Year
1
Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole. 38
20413982 2010
2
Predisposing factors for nevirapine toxicity among AIDS patients with low baseline CD4 count. 38
18035802 2007
3
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. 38
17442935 2007
4
Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient. 38
16352777 2006
5
Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. 38
7602118 1995
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Variations for Sulfamethoxazole Allergy

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Expression for Sulfamethoxazole Allergy

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Search GEO for disease gene expression data for Sulfamethoxazole Allergy.
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Pathways for Sulfamethoxazole Allergy

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Pathways related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.82 MPO IL5 IL4 CD86 CD80 CD40
2
Akt Signaling 64
Show member pathways
 13.22 IL5 IL4 CD80 CD40 CD4
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.14 IL5 IL4 CD86 CD80 CD40 CD4
4
PAK Pathway 64
Show member pathways
 13.09 IL5 IL4 CD80 CD40 CD4
5
Allograft rejection 37 1
Show member pathways
 12.59 IL5 IL4 CD86 CD80 CD40 CD4
6
Th17 cell differentiation 37
Show member pathways
 12.43 IL5 IL4 CD86 CD4
7
Immune response NFAT in immune response 22
Show member pathways
 12.39 IL4 CD86 CD80 CD40 CD4
8
T cell receptor signaling pathway 37
Show member pathways
 12.38 IL5 IL4 CD83 CD4
9
ICos-ICosL Pathway in T-Helper Cell 64
Show member pathways
 12.19 CD86 CD80 CD40 CD4
10
Transcriptional misregulation in cancer 37
12.09 MPO CD86 CD40
11
CD28 co-stimulation 66
Show member pathways
 12.03 CD86 CD80 CD4
12
Cell adhesion molecules (CAMs) 37
11.92 CD86 CD80 CD40 CD4
13
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.91 IL5 IL4 CD80 CD4
14
Th1 Differentiation Pathway 65
Show member pathways
 11.9 CD86 CD80 CD4
15
TCR signaling in naive CD4+ T cells 1
Show member pathways
 11.81 CD86 CD80 CD4
16
Hematopoietic cell lineage 37
11.75 IL5 IL4 CD4
17
Innate Lymphoid Cell Differentiation Pathways 65
11.66 IL5 IL4 CD4
18
CTLA4 Signaling 64
11.57 CD86 CD80 CD4
19
Phenytoin Pathway, Pharmacokinetics 61
Show member pathways
 11.51 MPO CYP2C9 CYP2C8
20
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.47 IL4 CD86 CD80 CD40
21
T Cell Co-Signaling Pathway: Ligand-Receptor Interactions 65
11.43 CD86 CD80 CD40
22
DNA damage_Role of Brca1 and Brca2 in DNA repair 22
11.42 CD86 CD80 CD4
23
B Cell Development Pathways 65
11.38 CD86 CD83 CD80 CD40 CD4
24
Interleukin-10 signaling 66
11.34 IL4 CD86 CD80
25
Tamoxifen metabolism 1
Show member pathways
 11.27 CYP2C9 CYP2C8
26
Primary immunodeficiency 37
11.24 CD40 CD4
27
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.23 MPO IL5 IL4 CD86 CD83 CD80
28
Th2 Differentiation Pathway 65
11.22 IL5 IL4 CD86 CD80 CD4
29
Nur77 Signaling in T-Cell 64
11.21 CD86 CD80
30
Development and heterogeneity of the ILC family 1
11.17 IL5 IL4
31
Erlotinib Pathway, Pharmacokinetics 61
Show member pathways
 11.17 CYP2C9 CYP2C8
32
CD40/CD40L signaling 1
11.14 IL4 CD40
33
HETE and HPETE biosynthesis and metabolism 22
Show member pathways
 11.09 CYP2C9 CYP2C8
34
Caffeine Pathway, Pharmacokinetics 61
Show member pathways
 11.07 CYP2C9 CYP2C8
35
OX40 Pathway 64
11.07 IL5 IL4
36
G-protein signaling_RhoB regulation pathway 22
11.05 IL5 IL4 CD80
37
Cytokines and Inflammatory Response 1
11.04 IL5 IL4 CD4
38
Naphthalene metabolism 22
11.01 CYP2C9 CYP2C8
39
Inflammatory Response Pathway 1
10.87 IL5 IL4 CD86 CD80 CD40
40
Arachidonate Epoxygenase / Epoxide Hydrolase 1
10.41 CYP2C9 CYP2C8
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GO Terms for Sulfamethoxazole Allergy

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Cellular components related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 CD86 CD80 CD40 CD4
2 external side of plasma membrane GO:0009897 9.02 CD86 CD83 CD80 CD40 CD4

Biological processes related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.77 IL5 IL4 CD86 CD80 CD4
2 cell surface receptor signaling pathway GO:0007166 9.76 CD86 CD80 CD4
3 immune response GO:0006955 9.72 IL5 IL4 CD86 CD80 CD4
4 T cell activation GO:0042110 9.59 IL4 CD4
5 negative regulation of T cell proliferation GO:0042130 9.58 CD86 CD80
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.58 IL5 CD80 CD4
7 B cell activation GO:0042113 9.57 IL4 CD40
8 exogenous drug catabolic process GO:0042738 9.56 CYP2C9 CYP2C8
9 drug metabolic process GO:0017144 9.55 CYP2C9 CYP2C8
10 cytokine-mediated signaling pathway GO:0019221 9.55 IL5 IL4 CD86 CD80 CD4
11 organic acid metabolic process GO:0006082 9.54 CYP2C9 CYP2C8
12 long-chain fatty acid biosynthetic process GO:0042759 9.52 CYP2C9 CYP2C8
13 cellular response to lipopolysaccharide GO:0071222 9.51 CD86 CD80
14 epoxygenase P450 pathway GO:0019373 9.49 CYP2C9 CYP2C8
15 positive regulation of isotype switching to IgG isotypes GO:0048304 9.48 IL4 CD40
16 omega-hydroxylase P450 pathway GO:0097267 9.46 CYP2C9 CYP2C8
17 oxidative demethylation GO:0070989 9.43 CYP2C9 CYP2C8
18 positive regulation of B cell proliferation GO:0030890 9.43 IL5 IL4 CD40
19 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.13 CD86 CD80 CD4
20 positive regulation of T cell proliferation GO:0042102 8.92 IL4 CD86 CD80 CD4

Molecular functions related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.61 CD86 CD40 CD4
2 heme binding GO:0020037 9.43 MPO CYP2C9 CYP2C8
3 steroid hydroxylase activity GO:0008395 9.4 CYP2C9 CYP2C8
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.37 CYP2C9 CYP2C8
5 virus receptor activity GO:0001618 9.33 CD86 CD80 CD4
6 arachidonic acid epoxygenase activity GO:0008392 9.32 CYP2C9 CYP2C8
7 caffeine oxidase activity GO:0034875 8.96 CYP2C9 CYP2C8
8 coreceptor activity GO:0015026 8.8 CD86 CD80 CD4
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Sources for Sulfamethoxazole Allergy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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