Sulfamethoxazole Allergy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Sulfamethoxazole Allergy

MalaCards integrated aliases for Sulfamethoxazole Allergy:

Name: Sulfamethoxazole Allergy ¹² ¹⁵

Sulphamethoxazole Allergy ¹²

Smx Allergy ¹²

Smz Allergy ¹²

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0040016

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Summaries for Sulfamethoxazole Allergy

Disease Ontology : ¹² A drug allergy that has allergic trigger sulfamethoxazole.

MalaCards based summary : Sulfamethoxazole Allergy, also known as sulphamethoxazole allergy, is related to co-trimoxazole allergy and hypertrophy of tongue papillae. An important gene associated with Sulfamethoxazole Allergy is CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Serotonergic synapse. Affiliated tissues include t cells.

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Related Diseases for Sulfamethoxazole Allergy

Diseases related to Sulfamethoxazole Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)

#	Related Disease	Score	Top Affiliating Genes
1	co-trimoxazole allergy	11.2
2	hypertrophy of tongue papillae	10.0	CYP2C9 CYP2C8
3	light fixation seizure syndrome	9.8	CD40LG CD40
4	geotrichosis	9.8	CD40LG CD40
5	immunodeficiency with hyper-igm, type 4	9.8	CD40LG CD40
6	inflammatory bowel disease 16	9.8	CD40LG CD40
7	immunodeficiency with hyper-igm, type 5	9.8	CD40LG CD40
8	immunodeficiency with hyper-igm, type 3	9.8	CD40LG CD40
9	gilbert syndrome	9.8	CYP2C9 CYP2C8
10	immunodeficiency with hyper-igm, type 2	9.8	CD40LG CD40
11	immunoglobulin alpha deficiency	9.8	CD40LG CD40
12	cd40 ligand deficiency	9.8	CD40LG CD40
13	plasmodium vivax malaria	9.8	CD40LG CD40
14	immunodeficiency with hyper-igm, type 1	9.8	CD40LG CD40
15	waldenstroem's macroglobulinemia	9.8	CD40LG CD40
16	macroglobulinemia	9.8	CD40LG CD40
17	b cell deficiency	9.7	CD40LG CD40
18	agammaglobulinemia, x-linked	9.7	CD40LG CD40
19	agammaglobulinemia	9.7	CD40LG CD40
20	toxoplasmosis	9.7	CD40LG CD40
21	toxic shock syndrome	9.7	CD40LG CD40
22	autoimmune disease of musculoskeletal system	9.6	CD40LG CD40
23	common variable immunodeficiency	9.5	CD83 CD40LG CD40
24	myocarditis	9.5	CD40LG CD40

Graphical network of the top 20 diseases related to Sulfamethoxazole Allergy:

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Symptoms & Phenotypes for Sulfamethoxazole Allergy

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Drugs & Therapeutics for Sulfamethoxazole Allergy

Search Clinical Trials , NIH Clinical Center for Sulfamethoxazole Allergy

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Genetic Tests for Sulfamethoxazole Allergy

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Anatomical Context for Sulfamethoxazole Allergy

MalaCards organs/tissues related to Sulfamethoxazole Allergy:

⁴⁰

T Cells

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Publications for Sulfamethoxazole Allergy

Articles related to Sulfamethoxazole Allergy:

#	Title	Authors	PMID	Year
1	Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole. ⁶¹	Zawodniak A...Pichler WJ	20413982	2010
2	Predisposing factors for nevirapine toxicity among AIDS patients with low baseline CD4 count. ⁶¹	Tansuphaswadikul S...Maek-a-nantawat W	18035802	2007
3	Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. ⁶¹	Sanderson JP...Park BK	17442935	2007
4	Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient. ⁶¹	Juang P...Zolty R	16352777	2006
5	Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. ⁶¹	Mauri-Hellweg D...Pichler WJ	7602118	1995

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Genes for Sulfamethoxazole Allergy

Genes related to Sulfamethoxazole Allergy (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	5.28	DISEASES inferred ¹⁵
2	CD83	CD83 Molecule	Protein Coding	4.93	DISEASES inferred ¹⁵
3	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	4.77	DISEASES inferred ¹⁵
4	PPP1R12C	Protein Phosphatase 1 Regulatory Subunit 12C	Protein Coding	4.49	DISEASES inferred ¹⁵
5	CD40	CD40 Molecule	Protein Coding	4.45	DISEASES inferred ¹⁵
6	CD40LG	CD40 Ligand	Protein Coding	4.24	DISEASES inferred ¹⁵

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Variations for Sulfamethoxazole Allergy

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Expression for Sulfamethoxazole Allergy

Search GEO for disease gene expression data for Sulfamethoxazole Allergy.

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Pathways for Sulfamethoxazole Allergy

Pathways related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Lipid and atherosclerosis ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.7	CYP2C9 CYP2C8 CD40LG CD40
2	Serotonergic synapse ³⁶	11.67	CYP2C9 CYP2C8
3	Linoleic acid metabolism ³⁶ Show member pathways alpha-Linolenic acid metabolism ³⁶ Arachidonic acid metabolism ³⁶	11.66	CYP2C9 CYP2C8
4	Statin Pathway - Generalized, Pharmacokinetics ⁶⁰ Show member pathways Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics ⁶⁰ Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics ⁶⁰ Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics ⁶⁰ Clobazam Pathway, Pharmacokinetics ⁶⁰ Diclofenac Metabolic Pathway ¹ Diclofenac Pathway, Pharmacokinetics ⁶⁰ Fluvastatin Pathway, Pharmacokinetics ⁶⁰ Ibuprofen Pathway, Pharmacokinetics ⁶⁰ Pravastatin Pathway, Pharmacokinetics ⁶⁰ Rosiglitazone Pathway, Pharmacokinetics ⁶⁰ Rosuvastatin Pathway, Pharmacokinetics ⁶⁰	11.65	CYP2C9 CYP2C8
5	Imipramine/Desipramine Pathway, Pharmacokinetics ⁶⁰ Show member pathways Amitriptyline and Nortriptyline Pathway, Pharmacokinetics ⁶⁰ Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ⁶⁵ Candesartan Pathway, Pharmacokinetics ⁶⁰ Citalopram Pathway, Pharmacokinetics ⁶⁰ Clomipramine Pathway, Pharmacokinetics ⁶⁰ Clozapine Pathway, Pharmacokinetics ⁶⁰ Ivacaftor pathway, pharmacokinetics/pharmacodynamics ⁶⁰ Lidocaine metabolism ¹ Metoprolol Pathway, Pharmacokinetics ⁶⁰ Nevirapine Pathway, Pharmacokinetics ⁶⁰ Olanzapine Pathway, Pharmacokinetics ⁶⁰ Paroxetine Pathway, Pharmacokinetics ⁶⁰ Pimozide Pathway, Pharmacokinetics ⁶⁰ Proton Pump Inhibitor Pathway, Pharmacokinetics ⁶⁰ Tacrolimus/Cyclosporine Pathway, Pharmacokinetics ⁶⁰ Venlafaxine Pathway, Pharmacokinetics ⁶⁰ Verapamil Pathway, Pharmacokinetics ⁶⁰ Warfarin Pathway, Pharmacokinetics ⁶⁰	11.63	CYP2C9 CYP2C8
6	NF-kappa B signaling pathway ³⁶	11.59	CD40LG CD40
7	TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions ⁶⁴ Show member pathways TNFs bind their physiological receptors ⁶⁵	11.48	CD40LG CD40
8	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway ²³	11.42	CD40LG CD40
9	IgA-Producing B Cells in the Intestine ⁶⁴	11.37	CD40LG CD40
10	Phenytoin Pathway, Pharmacokinetics ⁶⁰ Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶⁰ Carbamazepine Pathway, Pharmacokinetics ⁶⁰ Cyclophosphamide Pathway, Pharmacokinetics ⁶⁰ Efavirenz Pathway, Pharmacokinetics ⁶⁰ Sorafenib Pharmacokinetics ⁶⁰	11.34	CYP2C9 CYP2C8
11	Codeine and Morphine Metabolism ¹ Show member pathways Carvedilol Pathway, Pharmacokinetics ⁶⁰ Clopidogrel Pathway, Pharmacokinetics ⁶⁰ Codeine and Morphine Pathway, Pharmacokinetics ⁶⁰ Macrolide Antibiotic Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Oxycodone Pathway, Pharmacokinetics ⁶⁰ Tramadol Pharmacokinetics ⁶⁰	11.32	CYP2C9 CYP2C8
12	Androstenedione and testosterone biosynthesis and metabolism p.1 ²³ Show member pathways Estrogen biosynthesis ²³ Estrone metabolism ²³ Steroid Biosynthesis ¹	11.24	CYP2C9 CYP2C8
13	Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Show member pathways Bosutinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Nilotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Taxane Pathway, Pharmacokinetics ⁶⁰	11.21	CYP2C9 CYP2C8
14	Malaria ³⁶	11.18	CD40LG CD40
15	Tamoxifen metabolism ¹ Show member pathways Tamoxifen Pathway, Pharmacokinetics ⁶⁰	11.05	CYP2C9 CYP2C8
16	Primary immunodeficiency ³⁶	11.01	CD40LG CD40
17	Inflammatory Response Pathway ¹	10.89	CD40LG CD40
18	A-beta Pathways: Uptake and Degradation ⁶⁴	10.83	CD40LG CD40
19	CD40/CD40L signaling ¹	10.73	CD40LG CD40
20	HETE and HPETE biosynthesis and metabolism ²³ Show member pathways lipoxin biosynthesis ¹ resolvin D biosynthesis ¹ Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ⁶⁵	10.59	CYP2C9 CYP2C8
21	Naphthalene metabolism ²³	10.34	CYP2C9 CYP2C8
22	Arachidonate Epoxygenase / Epoxide Hydrolase ¹	9.47	CYP2C9 CYP2C8

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GO Terms for Sulfamethoxazole Allergy

Cellular components related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	organelle membrane	GO:0031090	8.96	CYP2C9 CYP2C8
2	external side of plasma membrane	GO:0009897	8.8	CD83 CD40LG CD40

Biological processes related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	platelet activation	GO:0030168	9.58	CD40 CD40LG
2	xenobiotic metabolic process	GO:0006805	9.57	CYP2C9 CYP2C8
3	positive regulation of interleukin-12 production	GO:0032735	9.56	CD40LG CD40
4	positive regulation of interleukin-10 production	GO:0032733	9.55	CD83 CD40LG
5	arachidonic acid metabolic process	GO:0019369	9.54	CYP2C9 CYP2C8
6	B cell proliferation	GO:0042100	9.52	CD40LG CD40
7	estrogen metabolic process	GO:0008210	9.51	CYP2C9 CYP2C8
8	drug metabolic process	GO:0017144	9.49	CYP2C9 CYP2C8
9	positive regulation of endothelial cell apoptotic process	GO:2000353	9.48	CD40LG CD40
10	long-chain fatty acid biosynthetic process	GO:0042759	9.46	CYP2C9 CYP2C8
11	exogenous drug catabolic process	GO:0042738	9.43	CYP2C9 CYP2C8
12	organic acid metabolic process	GO:0006082	9.4	CYP2C9 CYP2C8
13	epoxygenase P450 pathway	GO:0019373	9.37	CYP2C9 CYP2C8
14	oxidative demethylation	GO:0070989	9.32	CYP2C9 CYP2C8
15	omega-hydroxylase P450 pathway	GO:0097267	9.26	CYP2C9 CYP2C8
16	CD40 signaling pathway	GO:0023035	9.16	CD40LG CD40
17	regulation of immunoglobulin production	GO:0002637	8.96	CD40LG CD40
18	icosanoid biosynthetic process	GO:0046456	8.62	CYP2C9 CYP2C8

Molecular functions related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	monooxygenase activity	GO:0004497	9.4	CYP2C9 CYP2C8
2	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	9.37	CYP2C9 CYP2C8
3	steroid hydroxylase activity	GO:0008395	9.32	CYP2C9 CYP2C8
4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO:0016712	9.26	CYP2C9 CYP2C8
5	aromatase activity	GO:0070330	9.16	CYP2C9 CYP2C8
6	arachidonic acid epoxygenase activity	GO:0008392	8.96	CYP2C9 CYP2C8
7	caffeine oxidase activity	GO:0034875	8.62	CYP2C9 CYP2C8

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Sources for Sulfamethoxazole Allergy

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