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MCID: SLF017
MIFTS: 29

Sulfamethoxazole Allergy

Categories: Immune diseases
Genes Related diseases Pathways
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Aliases & Classifications for Sulfamethoxazole Allergy

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MalaCards integrated aliases for Sulfamethoxazole Allergy:

Name: Sulfamethoxazole Allergy 12 15
Sulphamethoxazole Allergy 12
Smx Allergy 12
Smz Allergy 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0040016
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Summaries for Sulfamethoxazole Allergy

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Disease Ontology : 12 A drug allergy that has_allergic_trigger sulfamethoxazole.

MalaCards based summary : Sulfamethoxazole Allergy, also known as sulphamethoxazole allergy, is related to co-trimoxazole allergy and light fixation seizure syndrome. An important gene associated with Sulfamethoxazole Allergy is CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Sulfamethoxazole Allergy

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Diseases related to Sulfamethoxazole Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 co-trimoxazole allergy 11.3
2 light fixation seizure syndrome 10.3 CD40 CD40LG
3 immunodeficiency with hyper-igm, type 4 10.3 CD40 CD40LG
4 cd40 ligand deficiency 10.3 CD40 CD40LG
5 hyperimmunoglobulin syndrome 10.3 CD40 CD40LG
6 immunodeficiency with hyper-igm, type 3 10.3 CD40 CD40LG
7 penicilliosis 10.2 CD40 CD86
8 acute myocarditis 10.2 CD40 CD86
9 common wart 10.2 CD40 CD80
10 plague 10.2 CD83 CD86
11 type 1 diabetes mellitus 13 10.2 CD80 CD86
12 type 1 diabetes mellitus 6 10.2 CD80 CD86
13 immunodeficiency with hyper-igm, type 2 10.2 CD40 CD40LG
14 myositis fibrosa 10.2 CD80 CD86
15 spondylarthropathy 10.1 CD40 CD80
16 pustulosis palmaris et plantaris 10.1 CD40LG IL5
17 autoimmune peripheral neuropathy 10.1 CD80 CD86
18 buruli ulcer 10.1 CD40LG IL4
19 anterior scleritis 10.1 IL5 MPO
20 myocarditis 10.1 CD40 CD40LG CD86
21 nickel allergic contact dermatitis 10.1 IL4 IL5
22 cough variant asthma 10.1 IL4 IL5
23 scleritis 10.1 IL4 IL5
24 egg allergy 10.1 IL4 IL5
25 inflammatory bowel disease 4 10.0 IL4 IL5
26 intrinsic asthma 10.0 IL4 IL5
27 trichinosis 10.0 IL4 IL5
28 apple allergy 10.0 IL4 IL5
29 non-suppurative otitis media 10.0 IL4 IL5
30 latex allergy 10.0 IL4 IL5
31 eosinophilic meningitis 10.0 IL4 IL5
32 intestinal schistosomiasis 10.0 IL4 IL5
33 chronic tic disorder 10.0 IL4 IL5
34 filarial elephantiasis 10.0 IL4 IL5
35 chronic conjunctivitis 10.0 IL4 IL5
36 eosinophilic gastritis 10.0 IL4 IL5
37 kimura disease 10.0 IL4 IL5
38 vernal keratoconjunctivitis 10.0 IL4 IL5
39 toxic oil syndrome 10.0 IL4 IL5
40 urinary schistosomiasis 10.0 IL4 IL5
41 churg-strauss syndrome 10.0 IL5 MPO
42 folliculitis 10.0 IL4 IL5
43 enterobiasis 10.0 IL4 IL5
44 conjunctival disease 10.0 IL4 IL5
45 immunodeficiency with hyper-igm, type 1 10.0 CD40 CD40LG IL4
46 transient hypogammaglobulinemia of infancy 10.0 CD40 CD40LG IL4
47 pneumonia 10.0 CD40LG IL5 MPO
48 toxoplasmosis 10.0 CD40 CD40LG IL4
49 allergic bronchopulmonary aspergillosis 10.0 IL4 IL5
50 milk allergy 9.9 IL4 IL5

Graphical network of the top 20 diseases related to Sulfamethoxazole Allergy:



Diseases related to Sulfamethoxazole Allergy
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Symptoms & Phenotypes for Sulfamethoxazole Allergy

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GenomeRNAi Phenotypes related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 CD40LG CYP2C8 CYP2C9 IL2 MPO
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 CD40LG CYP2C8 CYP2C9 IL2 MPO CD40

MGI Mouse Phenotypes related to Sulfamethoxazole Allergy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 CD40 CD40LG CD80 CD83 CD86 IL2
2 hematopoietic system MP:0005397 9.61 CD40 CD40LG CD80 CD83 CD86 IL2
3 immune system MP:0005387 9.28 CD40 CD40LG CD80 CD83 CD86 IL2
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Drugs & Therapeutics for Sulfamethoxazole Allergy

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Search Clinical Trials , NIH Clinical Center for Sulfamethoxazole Allergy

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Genetic Tests for Sulfamethoxazole Allergy

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Anatomical Context for Sulfamethoxazole Allergy

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Publications for Sulfamethoxazole Allergy

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Variations for Sulfamethoxazole Allergy

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Expression for Sulfamethoxazole Allergy

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Search GEO for disease gene expression data for Sulfamethoxazole Allergy.
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Pathways for Sulfamethoxazole Allergy

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Pathways related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.85 CD40 CD40LG CD80 CD86 IL2 IL4
2
PEDF Induced Signaling 65
Show member pathways
 13.51 CD40 CD40LG CD80 IL2 IL4 IL5
3
Akt Signaling 65
Show member pathways
 13.26 CD40 CD40LG CD80 IL2 IL4 IL5
4
Cytokine Signaling in Immune system 67
Show member pathways
 13.2 CD40 CD40LG CD80 CD86 IL2 IL4
5
PAK Pathway 65
Show member pathways
 13.15 CD40 CD40LG CD80 IL2 IL4 IL5
6
Allograft rejection 1 38
Show member pathways
 12.65 CD40 CD40LG CD80 CD86 IL2 IL4
7
Th17 cell differentiation 38
Show member pathways
 12.48 CD86 IL2 IL4 IL5
8
NF-kappaB Signaling 4
12.44 CD40LG CD83 IL2 IL4 MPO
9
Immune response NFAT in immune response 23
Show member pathways
 12.44 CD40 CD40LG CD80 CD86 IL2 IL4
10
T cell receptor signaling pathway 38
Show member pathways
 12.32 CD40LG CD83 IL2 IL4 IL5
11
ICos-ICosL Pathway in T-Helper Cell 65
Show member pathways
 12.27 CD40 CD40LG CD80 CD86 IL2
12
Selenium Micronutrient Network 1
Show member pathways
 12.19 IL2 IL4 MPO
13
Toxoplasmosis 38
Show member pathways
 12.12 CD40 CD40LG IL4
14
Transcriptional misregulation in cancer 38
12.11 CD40 CD86 MPO
15
Cell adhesion molecules (CAMs) 38
12.04 CD40 CD40LG CD80 CD86
16
Immune response IFN gamma signaling pathway 23
Show member pathways
 11.96 CD80 IL2 IL4 IL5
17
Th1 Differentiation Pathway 66
Show member pathways
 11.94 CD80 CD86 IL2
18
Glucocorticoid receptor regulatory network 1
11.72 IL2 IL4 IL5
19
Innate Lymphoid Cell Differentiation Pathways 66
11.7 IL2 IL4 IL5
20
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.66 CD40LG IL2 IL4 IL5
21
Phenytoin Pathway, Pharmacokinetics 62
Show member pathways
 11.59 CYP2C8 CYP2C9 MPO
22
IL4-mediated signaling events 1
11.57 CD40LG IL4 IL5
23
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.57 CD40 CD80 CD86 IL2 IL4
24
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.56 CD80 CD83 CD86 IL2 IL4 IL5
25
T Cell Co-Signaling Pathway: Ligand-Receptor Interactions 66
11.5 CD40 CD40LG CD80 CD86
26
Interleukin-10 signaling 67
11.45 CD80 CD86 IL4
27
B Cell Development Pathways 66
11.38 CD40 CD40LG CD80 CD83 CD86
28
Tamoxifen metabolism 1
Show member pathways
 11.28 CYP2C8 CYP2C9
29
Primary immunodeficiency 38
11.26 CD40 CD40LG
30
Nur77 Signaling in T-Cell 65
11.23 CD80 CD86
31
CD40/CD40L signaling 1
11.22 CD40 CD40LG IL4
32
Th2 Differentiation Pathway 66
11.22 CD80 CD86 IL2 IL4 IL5
33
Cytokines and Inflammatory Response 1
11.2 IL2 IL4 IL5
34
A-beta Pathways: Uptake and Degradation 66
11.18 CD40 CD40LG
35
Development and heterogeneity of the ILC family 1
11.18 IL4 IL5
36
OX40 Pathway 65
11.13 IL2 IL4 IL5
37
Caffeine Pathway, Pharmacokinetics 62
Show member pathways
 11.1 CYP2C8 CYP2C9
38
HETE and HPETE biosynthesis and metabolism 23
Show member pathways
 11.1 CYP2C8 CYP2C9
39
G-protein signaling_RhoB regulation pathway 23
11.09 CD40LG CD80 IL2 IL4 IL5
40
Erlotinib Pathway, Pharmacokinetics 62
Show member pathways
 11.04 CYP2C8 CYP2C9
41
Naphthalene metabolism 23
11.03 CYP2C8 CYP2C9
42
G-protein signaling_Rap2B regulation pathway 23
10.89 CD40LG CD80 IL2 IL4 IL5
43
Inflammatory Response Pathway 1
10.69 CD40 CD40LG CD80 CD86 IL2 IL4
44
Arachidonate Epoxygenase / Epoxide Hydrolase 1
10.46 CYP2C8 CYP2C9
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GO Terms for Sulfamethoxazole Allergy

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Cellular components related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.46 CD40 CD40LG CD80 CD86
2 extracellular space GO:0005615 9.43 CD40 CD40LG IL2 IL4 IL5 MPO
3 external side of plasma membrane GO:0009897 9.02 CD40 CD40LG CD80 CD83 CD86

Biological processes related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.94 CD80 CD86 IL4 IL5
2 negative regulation of apoptotic process GO:0043066 9.92 CD40LG IL2 IL4 MPO
3 regulation of signaling receptor activity GO:0010469 9.83 CD40LG IL2 IL4 IL5
4 regulation of immune response GO:0050776 9.81 CD40 CD40LG IL4
5 cellular response to lipopolysaccharide GO:0071222 9.74 CD40 CD80 CD86
6 immune response GO:0006955 9.73 CD40LG CD80 CD86 IL2 IL4 IL5
7 cytokine-mediated signaling pathway GO:0019221 9.72 CD80 CD86 IL2 IL4 IL5
8 B cell proliferation GO:0042100 9.63 CD40 CD40LG
9 B cell activation GO:0042113 9.62 CD40 IL4
10 drug metabolic process GO:0017144 9.61 CYP2C8 CYP2C9
11 exogenous drug catabolic process GO:0042738 9.61 CYP2C8 CYP2C9
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 CD40 IL2 IL4
13 positive regulation of interleukin-12 production GO:0032735 9.6 CD40 CD40LG
14 positive regulation of interleukin-10 production GO:0032733 9.59 CD40LG CD83
15 organic acid metabolic process GO:0006082 9.58 CYP2C8 CYP2C9
16 positive regulation of endothelial cell apoptotic process GO:2000353 9.58 CD40 CD40LG
17 long-chain fatty acid biosynthetic process GO:0042759 9.56 CYP2C8 CYP2C9
18 epoxygenase P450 pathway GO:0019373 9.55 CYP2C8 CYP2C9
19 positive regulation of T cell differentiation GO:0045582 9.54 IL2 IL4
20 T cell costimulation GO:0031295 9.54 CD40LG CD80 CD86
21 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.51 CD80 CD86
22 positive regulation of immunoglobulin secretion GO:0051024 9.49 IL2 IL5
23 omega-hydroxylase P450 pathway GO:0097267 9.48 CYP2C8 CYP2C9
24 oxidative demethylation GO:0070989 9.46 CYP2C8 CYP2C9
25 regulation of immunoglobulin secretion GO:0051023 9.4 CD40 CD40LG
26 positive regulation of isotype switching to IgG isotypes GO:0048304 9.33 CD40 IL2 IL4
27 positive regulation of B cell proliferation GO:0030890 9.26 CD40 IL2 IL4 IL5
28 positive regulation of T cell proliferation GO:0042102 9.02 CD40LG CD80 CD86 IL2 IL4

Molecular functions related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.5 IL2 IL4 IL5
2 coreceptor activity GO:0015026 9.43 CD80 CD86
3 heme binding GO:0020037 9.43 CYP2C8 CYP2C9 MPO
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.4 CYP2C8 CYP2C9
5 steroid hydroxylase activity GO:0008395 9.37 CYP2C8 CYP2C9
6 cytokine activity GO:0005125 9.26 CD40LG IL2 IL4 IL5
7 arachidonic acid epoxygenase activity GO:0008392 9.16 CYP2C8 CYP2C9
8 caffeine oxidase activity GO:0034875 8.62 CYP2C8 CYP2C9
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Sources for Sulfamethoxazole Allergy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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