Sulfamethoxazole Allergy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Sulfamethoxazole Allergy

MalaCards integrated aliases for Sulfamethoxazole Allergy:

Name: Sulfamethoxazole Allergy ¹² ¹⁵

Sulphamethoxazole Allergy ¹²

Smx Allergy ¹²

Smz Allergy ¹²

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0040016

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Summaries for Sulfamethoxazole Allergy

Disease Ontology : ¹² A drug allergy that has allergic trigger sulfamethoxazole.

MalaCards based summary : Sulfamethoxazole Allergy, also known as sulphamethoxazole allergy, is related to co-trimoxazole allergy and hypertrophy of tongue papillae. An important gene associated with Sulfamethoxazole Allergy is CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8), and among its related pathways/superpathways are Arachidonic acid metabolism and Linoleic acid metabolism. Affiliated tissues include t cells.

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Related Diseases for Sulfamethoxazole Allergy

Diseases related to Sulfamethoxazole Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	co-trimoxazole allergy	11.5
2	hypertrophy of tongue papillae	9.8	CYP2C9 CYP2C8
3	granulomatous disease, chronic, x-linked	9.4	PPP1R12C MECOM
4	chronic granulomatous disease	9.2	PPP1R12C MECOM
5	combined t cell and b cell immunodeficiency	9.0	PPP1R12C MECOM CD40

Graphical network of the top 20 diseases related to Sulfamethoxazole Allergy:

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Symptoms & Phenotypes for Sulfamethoxazole Allergy

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Drugs & Therapeutics for Sulfamethoxazole Allergy

Search Clinical Trials , NIH Clinical Center for Sulfamethoxazole Allergy

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Genetic Tests for Sulfamethoxazole Allergy

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Anatomical Context for Sulfamethoxazole Allergy

MalaCards organs/tissues related to Sulfamethoxazole Allergy:

⁴⁰

T Cells

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Publications for Sulfamethoxazole Allergy

Articles related to Sulfamethoxazole Allergy:

#	Title	Authors	PMID	Year
1	Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole. ⁶¹	Zawodniak A...Pichler WJ	20413982	2010
2	Predisposing factors for nevirapine toxicity among AIDS patients with low baseline CD4 count. ⁶¹	Tansuphaswadikul S...Maek-a-nantawat W	18035802	2007
3	Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. ⁶¹	Sanderson JP...Park BK	17442935	2007
4	Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient. ⁶¹	Juang P...Zolty R	16352777	2006
5	Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. ⁶¹	Mauri-Hellweg D...Pichler WJ	7602118	1995

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Genes for Sulfamethoxazole Allergy

Genes related to Sulfamethoxazole Allergy (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	5.28	DISEASES inferred ¹⁵
2	CD83	CD83 Molecule	Protein Coding	4.95	DISEASES inferred ¹⁵
3	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	4.77	DISEASES inferred ¹⁵
4	CD40	CD40 Molecule	Protein Coding	4.49	DISEASES inferred ¹⁵
5	PPP1R12C	Protein Phosphatase 1 Regulatory Subunit 12C	Protein Coding	4.49	DISEASES inferred ¹⁵
6	MECOM	MDS1 And EVI1 Complex Locus	Protein Coding	4.2	DISEASES inferred ¹⁵

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Variations for Sulfamethoxazole Allergy

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Expression for Sulfamethoxazole Allergy

Search GEO for disease gene expression data for Sulfamethoxazole Allergy.

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Pathways for Sulfamethoxazole Allergy

Pathways related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	Arachidonic acid metabolism ⁶⁵ Show member pathways alpha-tocopherol degradation ¹ Amodiaquine Pathway, Pharmacokinetics ⁶⁰ anandamide degradation ¹ C20 prostanoid biosynthesis ¹ COX reactions ⁶⁵ leukotriene biosynthesis ¹ Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) ⁶⁵ Synthesis of 12-eicosatetraenoic acid derivatives ⁶⁵ Synthesis of 15-eicosatetraenoic acid derivatives ⁶⁵ Synthesis of 5-eicosatetraenoic acids ⁶⁵ Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) ⁶⁵ Synthesis of Leukotrienes (LT) and Eoxins (EX) ⁶⁵ Synthesis of Lipoxins (LX) ⁶⁵ Synthesis of Prostaglandins (PG) and Thromboxanes (TX) ⁶⁵	11.74	CYP2C9 CYP2C8
2	Linoleic acid metabolism ³⁶ Show member pathways alpha-Linolenic acid metabolism ³⁶ Arachidonic acid metabolism ³⁶	11.58	CYP2C9 CYP2C8
3	Serotonergic synapse ³⁶	11.56	CYP2C9 CYP2C8
4	Statin Pathway - Generalized, Pharmacokinetics ⁶⁰ Show member pathways Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics ⁶⁰ Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics ⁶⁰ Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics ⁶⁰ Clobazam Pathway, Pharmacokinetics ⁶⁰ Diclofenac Metabolic Pathway ¹ Diclofenac Pathway, Pharmacokinetics ⁶⁰ Fluvastatin Pathway, Pharmacokinetics ⁶⁰ Ibuprofen Pathway, Pharmacokinetics ⁶⁰ Pravastatin Pathway, Pharmacokinetics ⁶⁰ Rosiglitazone Pathway, Pharmacokinetics ⁶⁰ Rosuvastatin Pathway, Pharmacokinetics ⁶⁰	11.53	CYP2C9 CYP2C8
5	Imipramine/Desipramine Pathway, Pharmacokinetics ⁶⁰ Show member pathways Amitriptyline and Nortriptyline Pathway, Pharmacokinetics ⁶⁰ Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ⁶⁵ Candesartan Pathway, Pharmacokinetics ⁶⁰ Citalopram Pathway, Pharmacokinetics ⁶⁰ Clomipramine Pathway, Pharmacokinetics ⁶⁰ Clozapine Pathway, Pharmacokinetics ⁶⁰ Colchicine Metabolic Pathway ¹ Doxepin Pathway, Pharmacokinetics ⁶⁰ Lidocaine metabolism ¹ Metoprolol Pathway, Pharmacokinetics ⁶⁰ Nevirapine Pathway, Pharmacokinetics ⁶⁰ Olanzapine Pathway, Pharmacokinetics ⁶⁰ Paroxetine Pathway, Pharmacokinetics ⁶⁰ Proton Pump Inhibitor Pathway, Pharmacokinetics ⁶⁰ Venlafaxine Pathway, Pharmacokinetics ⁶⁰ Verapamil Pathway, Pharmacokinetics ⁶⁰ Warfarin Pathway, Pharmacokinetics ⁶⁰	11.47	CYP2C9 CYP2C8
6	Carvedilol Pathway, Pharmacokinetics ⁶⁰ Show member pathways Clopidogrel Pathway, Pharmacokinetics ⁶⁰ Codeine and Morphine Metabolism ¹ Codeine and Morphine Pathway, Pharmacokinetics ⁶⁰ Ivacaftor pathway, pharmacokinetics/pharmacodynamics ⁶⁰ Losartan Pathway, Pharmacokinetics ⁶⁰ Macrolide Antibiotic Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Oxycodone Pathway, Pharmacokinetics ⁶⁰ Tacrolimus/Cyclosporine Pathway, Pharmacokinetics ⁶⁰ Tramadol Pharmacokinetics ⁶⁰	11.31	CYP2C9 CYP2C8
7	Phenytoin Pathway, Pharmacokinetics ⁶⁰ Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶⁰ Carbamazepine Pathway, Pharmacokinetics ⁶⁰ Cyclophosphamide Pathway, Pharmacokinetics ⁶⁰ Efavirenz Pathway, Pharmacokinetics ⁶⁰ Sorafenib Pharmacokinetics ⁶⁰	11.21	CYP2C9 CYP2C8
8	Androstenedione and testosterone biosynthesis and metabolism p.1 ²² Show member pathways Estrogen biosynthesis ²² Estrone metabolism ²² Steroid Biosynthesis ¹	11.1	CYP2C9 CYP2C8
9	Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Show member pathways Bosutinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Nilotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Taxane Pathway, Pharmacokinetics ⁶⁰	11.04	CYP2C9 CYP2C8
10	Tamoxifen metabolism ¹ Show member pathways Tamoxifen Pathway, Pharmacokinetics ⁶⁰	10.85	CYP2C9 CYP2C8
11	HETE and HPETE biosynthesis and metabolism ²² Show member pathways lipoxin biosynthesis ¹ resolvin D biosynthesis ¹ Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ⁶⁵	10.59	CYP2C9 CYP2C8
12	Naphthalene metabolism ²²	10.34	CYP2C9 CYP2C8
13	Arachidonate Epoxygenase / Epoxide Hydrolase ¹	9.47	CYP2C9 CYP2C8

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GO Terms for Sulfamethoxazole Allergy

Cellular components related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	organelle membrane	GO:0031090	8.62	CYP2C9 CYP2C8

Biological processes related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	steroid metabolic process	GO:0008202	9.51	CYP2C9 CYP2C8
2	xenobiotic metabolic process	GO:0006805	9.49	CYP2C9 CYP2C8
3	arachidonic acid metabolic process	GO:0019369	9.48	CYP2C9 CYP2C8
4	long-chain fatty acid biosynthetic process	GO:0042759	9.46	CYP2C9 CYP2C8
5	exogenous drug catabolic process	GO:0042738	9.43	CYP2C9 CYP2C8
6	drug metabolic process	GO:0017144	9.4	CYP2C9 CYP2C8
7	organic acid metabolic process	GO:0006082	9.37	CYP2C9 CYP2C8
8	epoxygenase P450 pathway	GO:0019373	9.32	CYP2C9 CYP2C8
9	estrogen metabolic process	GO:0008210	9.26	CYP2C9 CYP2C8
10	oxidative demethylation	GO:0070989	9.16	CYP2C9 CYP2C8
11	omega-hydroxylase P450 pathway	GO:0097267	8.96	CYP2C9 CYP2C8
12	icosanoid biosynthetic process	GO:0046456	8.62	CYP2C9 CYP2C8

Molecular functions related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:0020037	9.46	CYP2C9 CYP2C8
2	iron ion binding	GO:0005506	9.43	CYP2C9 CYP2C8
3	monooxygenase activity	GO:0004497	9.4	CYP2C9 CYP2C8
4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	9.37	CYP2C9 CYP2C8
5	steroid hydroxylase activity	GO:0008395	9.32	CYP2C9 CYP2C8
6	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO:0016712	9.26	CYP2C9 CYP2C8
7	aromatase activity	GO:0070330	9.16	CYP2C9 CYP2C8
8	arachidonic acid epoxygenase activity	GO:0008392	8.96	CYP2C9 CYP2C8
9	caffeine oxidase activity	GO:0034875	8.62	CYP2C9 CYP2C8

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