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MCID: SLF017
MIFTS: 29

Sulfamethoxazole Allergy

Categories: Immune diseases
Genes Tissues Related diseases Pathways
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Aliases & Classifications for Sulfamethoxazole Allergy

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MalaCards integrated aliases for Sulfamethoxazole Allergy:

Name: Sulfamethoxazole Allergy 12 15
Sulphamethoxazole Allergy 12
Smx Allergy 12
Smz Allergy 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0040016
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Summaries for Sulfamethoxazole Allergy

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Disease Ontology : 12 A drug allergy that has_allergic_trigger sulfamethoxazole.

MalaCards based summary : Sulfamethoxazole Allergy, also known as sulphamethoxazole allergy, is related to co-trimoxazole allergy and light fixation seizure syndrome. An important gene associated with Sulfamethoxazole Allergy is CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include b cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Sulfamethoxazole Allergy

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Diseases related to Sulfamethoxazole Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 co-trimoxazole allergy 11.3
2 light fixation seizure syndrome 10.2 CD40 CD40LG
3 immunodeficiency with hyper-igm, type 4 10.2 CD40 CD40LG
4 cd40 ligand deficiency 10.2 CD40 CD40LG
5 hyperimmunoglobulin syndrome 10.2 CD40 CD40LG
6 immunodeficiency with hyper-igm, type 3 10.2 CD40 CD40LG
7 penicilliosis 10.1 CD40 CD86
8 common wart 10.1 CD40 CD80
9 acute myocarditis 10.1 CD40 CD86
10 plague 10.1 CD83 CD86
11 immunodeficiency with hyper-igm, type 2 10.1 CD40 CD40LG
12 type 1 diabetes mellitus 13 10.1 CD80 CD86
13 type 1 diabetes mellitus 6 10.1 CD80 CD86
14 myositis fibrosa 10.1 CD80 CD86
15 spondylarthropathy 10.1 CD40 CD80
16 autoimmune peripheral neuropathy 10.1 CD80 CD86
17 pustulosis palmaris et plantaris 10.0 CD40LG IL5
18 myocarditis 10.0 CD40 CD40LG CD86
19 anterior scleritis 10.0 IL5 MPO
20 pollen allergy 10.0 IL5 MPO
21 buruli ulcer 10.0 CD40LG IL4
22 churg-strauss syndrome 10.0 IL5 MPO
23 nickel allergic contact dermatitis 9.9 IL4 IL5
24 cough variant asthma 9.9 IL4 IL5
25 scleritis 9.9 IL4 IL5
26 egg allergy 9.9 IL4 IL5
27 atopic keratoconjunctivitis 9.9 IL4 IL5
28 gaucher disease, type ii 9.9 IL4 IL5
29 angiostrongyliasis 9.9 IL4 IL5
30 intrinsic asthma 9.9 IL4 IL5
31 trichinosis 9.9 IL4 IL5
32 inflammatory bowel disease 4 9.9 IL4 IL5
33 apple allergy 9.9 IL4 IL5
34 non-suppurative otitis media 9.9 IL4 IL5
35 latex allergy 9.9 IL4 IL5
36 eosinophilic meningitis 9.9 IL4 IL5
37 intestinal schistosomiasis 9.9 IL4 IL5
38 chronic tic disorder 9.9 IL4 IL5
39 filarial elephantiasis 9.9 IL4 IL5
40 pneumonia 9.9 CD40LG IL5 MPO
41 chronic conjunctivitis 9.9 IL4 IL5
42 eosinophilic gastritis 9.9 IL4 IL5
43 kimura disease 9.9 IL4 IL5
44 vernal keratoconjunctivitis 9.9 IL4 IL5
45 toxic oil syndrome 9.9 IL4 IL5
46 urinary schistosomiasis 9.9 IL4 IL5
47 folliculitis 9.9 IL4 IL5
48 b cell deficiency 9.9 CD40 CD40LG
49 vernal conjunctivitis 9.9 IL4 MPO
50 immunodeficiency with hyper-igm, type 1 9.9 CD40 CD40LG IL4

Graphical network of the top 20 diseases related to Sulfamethoxazole Allergy:



Diseases related to Sulfamethoxazole Allergy
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Symptoms & Phenotypes for Sulfamethoxazole Allergy

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GenomeRNAi Phenotypes related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.28 CD40LG CYP2C8 CYP2C9 MPO
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.28 CD40 CD40LG CYP2C8 CYP2C9 MPO

MGI Mouse Phenotypes related to Sulfamethoxazole Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 CD40 CD40LG CD80 CD83 CD86 IL4
2 hematopoietic system MP:0005397 9.56 CD40 CD40LG CD80 CD83 CD86 IL4
3 immune system MP:0005387 9.23 CD40 CD40LG CD80 CD83 CD86 IL4
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Drugs & Therapeutics for Sulfamethoxazole Allergy

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Search Clinical Trials , NIH Clinical Center for Sulfamethoxazole Allergy

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Genetic Tests for Sulfamethoxazole Allergy

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Anatomical Context for Sulfamethoxazole Allergy

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MalaCards organs/tissues related to Sulfamethoxazole Allergy:

41
B Cells
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Publications for Sulfamethoxazole Allergy

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Variations for Sulfamethoxazole Allergy

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Expression for Sulfamethoxazole Allergy

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Search GEO for disease gene expression data for Sulfamethoxazole Allergy.
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Pathways for Sulfamethoxazole Allergy

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Pathways related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.81 CD40 CD40LG CD80 CD86 IL4 IL5
2
Akt Signaling 64
Show member pathways
 13.21 CD40 CD40LG CD80 IL4 IL5
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.15 CD40 CD40LG CD80 CD86 IL4 IL5
4
PAK Pathway 64
Show member pathways
 13.06 CD40 CD40LG CD80 IL4 IL5
5
Allograft rejection 1 37
Show member pathways
 12.62 CD40 CD40LG CD80 CD86 IL4 IL5
6
NF-kappaB Signaling 4
12.41 CD40LG CD83 IL4 MPO
7
Immune response NFAT in immune response 22
Show member pathways
 12.39 CD40 CD40LG CD80 CD86 IL4
8
T cell receptor signaling pathway 37
Show member pathways
 12.27 CD40LG CD83 IL4 IL5
9
ICos-ICosL Pathway in T-Helper Cell 64
Show member pathways
 12.21 CD40 CD40LG CD80 CD86
10
Toxoplasmosis 37
Show member pathways
 12.08 CD40 CD40LG IL4
11
Transcriptional misregulation in cancer 37
12.07 CD40 CD86 MPO
12
Cell adhesion molecules (CAMs) 37
11.94 CD40 CD40LG CD80 CD86
13
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.63 CD40LG IL4 IL5
14
Phenytoin Pathway, Pharmacokinetics 61
Show member pathways
 11.53 CYP2C8 CYP2C9 MPO
15
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.52 CD40 CD80 CD86 IL4
16
IL4-mediated signaling events 1
11.51 CD40LG IL4 IL5
17
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.5 CD80 CD83 CD86 IL4 IL5 MPO
18
T Cell Co-Signaling Pathway: Ligand-Receptor Interactions 65
11.39 CD40 CD40LG CD80 CD86
19
Interleukin-10 signaling 66
11.38 CD80 CD86 IL4
20
B Cell Development Pathways 65
11.28 CD40 CD40LG CD80 CD83 CD86
21
Tamoxifen metabolism 1
Show member pathways
 11.26 CYP2C8 CYP2C9
22
Primary immunodeficiency 37
11.23 CD40 CD40LG
23
Th2 Differentiation Pathway 65
11.22 CD80 CD86 IL4 IL5
24
Nur77 Signaling in T-Cell 64
11.2 CD80 CD86
25
A-beta Pathways: Uptake and Degradation 65
11.16 CD40 CD40LG
26
Development and heterogeneity of the ILC family 1
11.16 IL4 IL5
27
Cytokines and Inflammatory Response 1
11.11 IL4 IL5
28
CD40/CD40L signaling 1
11.11 CD40 CD40LG IL4
29
Caffeine Pathway, Pharmacokinetics 61
Show member pathways
 11.07 CYP2C8 CYP2C9
30
HETE and HPETE biosynthesis and metabolism 22
Show member pathways
 11.07 CYP2C8 CYP2C9
31
OX40 Pathway 64
11.05 IL4 IL5
32
G-protein signaling_RhoB regulation pathway 22
11.03 CD40LG CD80 IL4 IL5
33
Erlotinib Pathway, Pharmacokinetics 61
Show member pathways
 10.99 CYP2C8 CYP2C9
34
Naphthalene metabolism 22
10.99 CYP2C8 CYP2C9
35
G-protein signaling_Rap2B regulation pathway 22
10.82 CD40LG CD80 IL4 IL5
36
Inflammatory Response Pathway 1
10.62 CD40 CD40LG CD80 CD86 IL4 IL5
37
Arachidonate Epoxygenase / Epoxide Hydrolase 1
10.43 CYP2C8 CYP2C9
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GO Terms for Sulfamethoxazole Allergy

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Cellular components related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 CD40 CD40LG CD80 CD86
2 external side of plasma membrane GO:0009897 9.02 CD40 CD40LG CD80 CD83 CD86

Biological processes related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.9 CD80 CD86 IL4 IL5
2 regulation of immune response GO:0050776 9.78 CD40 CD40LG IL4
3 cellular response to lipopolysaccharide GO:0071222 9.69 CD40 CD80 CD86
4 cytokine-mediated signaling pathway GO:0019221 9.67 CD80 CD86 IL4 IL5
5 negative regulation of T cell proliferation GO:0042130 9.62 CD80 CD86
6 B cell proliferation GO:0042100 9.61 CD40 CD40LG
7 B cell activation GO:0042113 9.59 CD40 IL4
8 drug metabolic process GO:0017144 9.58 CYP2C8 CYP2C9
9 exogenous drug catabolic process GO:0042738 9.58 CYP2C8 CYP2C9
10 positive regulation of interleukin-12 production GO:0032735 9.57 CD40 CD40LG
11 positive regulation of interleukin-10 production GO:0032733 9.56 CD40LG CD83
12 organic acid metabolic process GO:0006082 9.55 CYP2C8 CYP2C9
13 immune response GO:0006955 9.55 CD40LG CD80 CD86 IL4 IL5
14 positive regulation of endothelial cell apoptotic process GO:2000353 9.54 CD40 CD40LG
15 long-chain fatty acid biosynthetic process GO:0042759 9.52 CYP2C8 CYP2C9
16 epoxygenase P450 pathway GO:0019373 9.49 CYP2C8 CYP2C9
17 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.48 CD80 CD86
18 omega-hydroxylase P450 pathway GO:0097267 9.46 CYP2C8 CYP2C9
19 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 CD40 IL4
20 T cell costimulation GO:0031295 9.43 CD40LG CD80 CD86
21 oxidative demethylation GO:0070989 9.4 CYP2C8 CYP2C9
22 regulation of immunoglobulin secretion GO:0051023 9.32 CD40 CD40LG
23 positive regulation of B cell proliferation GO:0030890 9.13 CD40 IL4 IL5
24 positive regulation of T cell proliferation GO:0042102 8.92 CD40LG CD80 CD86 IL4

Molecular functions related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.54 CD40LG IL4 IL5
2 coreceptor activity GO:0015026 9.4 CD80 CD86
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.32 CYP2C8 CYP2C9
4 steroid hydroxylase activity GO:0008395 9.26 CYP2C8 CYP2C9
5 arachidonic acid epoxygenase activity GO:0008392 9.16 CYP2C8 CYP2C9
6 heme binding GO:0020037 9.13 CYP2C8 CYP2C9 MPO
7 caffeine oxidase activity GO:0034875 8.62 CYP2C8 CYP2C9
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Sources for Sulfamethoxazole Allergy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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