MCID: SLF017
MIFTS: 28

Sulfamethoxazole Allergy

Categories: Immune diseases

Aliases & Classifications for Sulfamethoxazole Allergy

MalaCards integrated aliases for Sulfamethoxazole Allergy:

Name: Sulfamethoxazole Allergy 12 15
Sulphamethoxazole Allergy 12
Smx Allergy 12
Smz Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040016

Summaries for Sulfamethoxazole Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger sulfamethoxazole.

MalaCards based summary : Sulfamethoxazole Allergy, also known as sulphamethoxazole allergy, is related to co-trimoxazole allergy and penicilliosis. An important gene associated with Sulfamethoxazole Allergy is CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include t cells, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Sulfamethoxazole Allergy

Diseases related to Sulfamethoxazole Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 co-trimoxazole allergy 11.5
2 penicilliosis 10.4 CD86 CD40
3 acute myocarditis 10.3 CD86 CD40
4 common wart 10.3 CD80 CD40
5 plague 10.3 CD86 CD83
6 type 1 diabetes mellitus 13 10.3 CD86 CD80
7 type 1 diabetes mellitus 6 10.3 CD86 CD80
8 myositis fibrosa 10.3 CD86 CD80
9 spondylarthropathy 10.2 CD80 CD40
10 immunodeficiency with hyper-igm, type 1 10.2 IL4 CD40
11 autoimmune peripheral neuropathy 10.2 CD86 CD80
12 anterior scleritis 10.1 MPO IL5
13 nickel allergic contact dermatitis 10.1 IL5 IL4
14 cough variant asthma 10.1 IL5 IL4
15 egg allergy 10.1 IL5 IL4
16 scleritis 10.1 IL5 IL4
17 atopic keratoconjunctivitis 10.1 IL5 IL4
18 inflammatory bowel disease 4 10.1 IL5 IL4
19 trichinosis 10.1 IL5 IL4
20 intrinsic asthma 10.1 IL5 IL4
21 angiostrongyliasis 10.1 IL5 IL4
22 apple allergy 10.1 IL5 IL4
23 churg-strauss syndrome 10.1 MPO IL5
24 gaucher disease, type ii 10.1 IL5 IL4
25 non-suppurative otitis media 10.1 IL5 IL4
26 eosinophilic meningitis 10.1 IL5 IL4
27 latex allergy 10.0 IL5 IL4
28 eosinophilic gastritis 10.0 IL5 IL4
29 chronic conjunctivitis 10.0 IL5 IL4
30 filarial elephantiasis 10.0 IL5 IL4
31 chronic tic disorder 10.0 IL5 IL4
32 intestinal schistosomiasis 10.0 IL5 IL4
33 kimura disease 10.0 IL5 IL4
34 transient hypogammaglobulinemia of infancy 10.0 IL4 CD40
35 toxic oil syndrome 10.0 IL5 IL4
36 vernal keratoconjunctivitis 10.0 IL5 IL4
37 urinary schistosomiasis 10.0 IL5 IL4
38 folliculitis 10.0 IL5 IL4
39 proliferative glomerulonephritis 10.0 MPO IL4
40 enterobiasis 10.0 IL5 IL4
41 conjunctival disease 10.0 IL5 IL4
42 milk allergy 10.0 IL5 IL4
43 vernal conjunctivitis 10.0 MPO IL4
44 allergic bronchopulmonary aspergillosis 9.9 IL5 IL4
45 pulmonary eosinophilia 9.9 IL5 IL4
46 paranasal sinus disease 9.9 IL5 IL4
47 onchocerciasis 9.8 IL5 IL4
48 nasal cavity disease 9.8 IL5 IL4
49 allergic conjunctivitis 9.8 IL5 IL4
50 yellow fever 9.8 IL5 IL4

Graphical network of the top 20 diseases related to Sulfamethoxazole Allergy:



Diseases related to Sulfamethoxazole Allergy

Symptoms & Phenotypes for Sulfamethoxazole Allergy

MGI Mouse Phenotypes related to Sulfamethoxazole Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 CD4 CD40 CD80 CD83 CD86 IL4
2 hematopoietic system MP:0005397 9.56 CD4 CD40 CD80 CD83 CD86 IL4
3 immune system MP:0005387 9.23 CD4 CD40 CD80 CD83 CD86 IL4

Drugs & Therapeutics for Sulfamethoxazole Allergy

Search Clinical Trials , NIH Clinical Center for Sulfamethoxazole Allergy

Genetic Tests for Sulfamethoxazole Allergy

Anatomical Context for Sulfamethoxazole Allergy

MalaCards organs/tissues related to Sulfamethoxazole Allergy:

41
T Cells

Publications for Sulfamethoxazole Allergy

Articles related to Sulfamethoxazole Allergy:

# Title Authors PMID Year
1
Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole. 38
20413982 2010
2
Predisposing factors for nevirapine toxicity among AIDS patients with low baseline CD4 count. 38
18035802 2007
3
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. 38
17442935 2007
4
Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient. 38
16352777 2006
5
Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. 38
7602118 1995

Variations for Sulfamethoxazole Allergy

Expression for Sulfamethoxazole Allergy

Search GEO for disease gene expression data for Sulfamethoxazole Allergy.

Pathways for Sulfamethoxazole Allergy

Pathways related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 MPO IL5 IL4 CD86 CD80 CD40
2
Show member pathways
13.22 IL5 IL4 CD80 CD40 CD4
3
Show member pathways
13.14 IL5 IL4 CD86 CD80 CD40 CD4
4
Show member pathways
13.09 IL5 IL4 CD80 CD40 CD4
5
Show member pathways
12.59 IL5 IL4 CD86 CD80 CD40 CD4
6
Show member pathways
12.43 IL5 IL4 CD86 CD4
7
Show member pathways
12.39 IL4 CD86 CD80 CD40 CD4
8
Show member pathways
12.38 IL5 IL4 CD83 CD4
9
Show member pathways
12.19 CD86 CD80 CD40 CD4
10 12.09 MPO CD86 CD40
11
Show member pathways
12.03 CD86 CD80 CD4
12 11.92 CD86 CD80 CD40 CD4
13
Show member pathways
11.91 IL5 IL4 CD80 CD4
14
Show member pathways
11.9 CD86 CD80 CD4
15
Show member pathways
11.81 CD86 CD80 CD4
16 11.75 IL5 IL4 CD4
17 11.66 IL5 IL4 CD4
18 11.57 CD86 CD80 CD4
19
Show member pathways
11.51 MPO CYP2C9 CYP2C8
20 11.47 IL4 CD86 CD80 CD40
21 11.43 CD86 CD80 CD40
22 11.42 CD86 CD80 CD4
23 11.38 CD86 CD83 CD80 CD40 CD4
24 11.34 IL4 CD86 CD80
25
Show member pathways
11.27 CYP2C9 CYP2C8
26 11.24 CD40 CD4
27 11.23 MPO IL5 IL4 CD86 CD83 CD80
28 11.22 IL5 IL4 CD86 CD80 CD4
29 11.21 CD86 CD80
30 11.17 IL5 IL4
31
Show member pathways
11.17 CYP2C9 CYP2C8
32 11.14 IL4 CD40
33
Show member pathways
11.09 CYP2C9 CYP2C8
34
Show member pathways
11.07 CYP2C9 CYP2C8
35 11.07 IL5 IL4
36 11.05 IL5 IL4 CD80
37 11.04 IL5 IL4 CD4
38 11.01 CYP2C9 CYP2C8
39 10.87 IL5 IL4 CD86 CD80 CD40
40 10.41 CYP2C9 CYP2C8

GO Terms for Sulfamethoxazole Allergy

Cellular components related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 CD86 CD80 CD40 CD4
2 external side of plasma membrane GO:0009897 9.02 CD86 CD83 CD80 CD40 CD4

Biological processes related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.77 IL5 IL4 CD86 CD80 CD4
2 cell surface receptor signaling pathway GO:0007166 9.76 CD86 CD80 CD4
3 immune response GO:0006955 9.72 IL5 IL4 CD86 CD80 CD4
4 T cell activation GO:0042110 9.59 IL4 CD4
5 negative regulation of T cell proliferation GO:0042130 9.58 CD86 CD80
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.58 IL5 CD80 CD4
7 B cell activation GO:0042113 9.57 IL4 CD40
8 exogenous drug catabolic process GO:0042738 9.56 CYP2C9 CYP2C8
9 drug metabolic process GO:0017144 9.55 CYP2C9 CYP2C8
10 cytokine-mediated signaling pathway GO:0019221 9.55 IL5 IL4 CD86 CD80 CD4
11 organic acid metabolic process GO:0006082 9.54 CYP2C9 CYP2C8
12 long-chain fatty acid biosynthetic process GO:0042759 9.52 CYP2C9 CYP2C8
13 cellular response to lipopolysaccharide GO:0071222 9.51 CD86 CD80
14 epoxygenase P450 pathway GO:0019373 9.49 CYP2C9 CYP2C8
15 positive regulation of isotype switching to IgG isotypes GO:0048304 9.48 IL4 CD40
16 omega-hydroxylase P450 pathway GO:0097267 9.46 CYP2C9 CYP2C8
17 oxidative demethylation GO:0070989 9.43 CYP2C9 CYP2C8
18 positive regulation of B cell proliferation GO:0030890 9.43 IL5 IL4 CD40
19 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.13 CD86 CD80 CD4
20 positive regulation of T cell proliferation GO:0042102 8.92 IL4 CD86 CD80 CD4

Molecular functions related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.61 CD86 CD40 CD4
2 heme binding GO:0020037 9.43 MPO CYP2C9 CYP2C8
3 steroid hydroxylase activity GO:0008395 9.4 CYP2C9 CYP2C8
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.37 CYP2C9 CYP2C8
5 virus receptor activity GO:0001618 9.33 CD86 CD80 CD4
6 arachidonic acid epoxygenase activity GO:0008392 9.32 CYP2C9 CYP2C8
7 caffeine oxidase activity GO:0034875 8.96 CYP2C9 CYP2C8
8 coreceptor activity GO:0015026 8.8 CD86 CD80 CD4

Sources for Sulfamethoxazole Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....