MCID: SLF017
MIFTS: 23

Sulfamethoxazole Allergy

Categories: Immune diseases

Aliases & Classifications for Sulfamethoxazole Allergy

MalaCards integrated aliases for Sulfamethoxazole Allergy:

Name: Sulfamethoxazole Allergy 12 15
Sulphamethoxazole Allergy 12
Smx Allergy 12
Smz Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040016

Summaries for Sulfamethoxazole Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger sulfamethoxazole.

MalaCards based summary : Sulfamethoxazole Allergy, also known as sulphamethoxazole allergy, is related to co-trimoxazole allergy and hypertrophy of tongue papillae. An important gene associated with Sulfamethoxazole Allergy is CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Serotonergic synapse. Affiliated tissues include t cells.

Related Diseases for Sulfamethoxazole Allergy

Graphical network of the top 20 diseases related to Sulfamethoxazole Allergy:



Diseases related to Sulfamethoxazole Allergy

Symptoms & Phenotypes for Sulfamethoxazole Allergy

Drugs & Therapeutics for Sulfamethoxazole Allergy

Search Clinical Trials , NIH Clinical Center for Sulfamethoxazole Allergy

Genetic Tests for Sulfamethoxazole Allergy

Anatomical Context for Sulfamethoxazole Allergy

MalaCards organs/tissues related to Sulfamethoxazole Allergy:

40
T Cells

Publications for Sulfamethoxazole Allergy

Articles related to Sulfamethoxazole Allergy:

# Title Authors PMID Year
1
Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole. 61
20413982 2010
2
Predisposing factors for nevirapine toxicity among AIDS patients with low baseline CD4 count. 61
18035802 2007
3
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. 61
17442935 2007
4
Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient. 61
16352777 2006
5
Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. 61
7602118 1995

Variations for Sulfamethoxazole Allergy

Expression for Sulfamethoxazole Allergy

Search GEO for disease gene expression data for Sulfamethoxazole Allergy.

Pathways for Sulfamethoxazole Allergy

Pathways related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 CYP2C9 CYP2C8 CD40LG CD40
2 11.67 CYP2C9 CYP2C8
3
Show member pathways
11.66 CYP2C9 CYP2C8
4
Show member pathways
11.65 CYP2C9 CYP2C8
5
Show member pathways
11.63 CYP2C9 CYP2C8
6 11.59 CD40LG CD40
7
Show member pathways
11.48 CD40LG CD40
8
Show member pathways
11.42 CD40LG CD40
9 11.37 CD40LG CD40
10
Show member pathways
11.34 CYP2C9 CYP2C8
11
Show member pathways
11.32 CYP2C9 CYP2C8
12
Show member pathways
11.24 CYP2C9 CYP2C8
13
Show member pathways
11.21 CYP2C9 CYP2C8
14 11.18 CD40LG CD40
15
Show member pathways
11.05 CYP2C9 CYP2C8
16 11.01 CD40LG CD40
17 10.89 CD40LG CD40
18 10.83 CD40LG CD40
19 10.73 CD40LG CD40
20
Show member pathways
10.59 CYP2C9 CYP2C8
21 10.34 CYP2C9 CYP2C8
22 9.47 CYP2C9 CYP2C8

GO Terms for Sulfamethoxazole Allergy

Cellular components related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.96 CYP2C9 CYP2C8
2 external side of plasma membrane GO:0009897 8.8 CD83 CD40LG CD40

Biological processes related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.58 CD40 CD40LG
2 xenobiotic metabolic process GO:0006805 9.57 CYP2C9 CYP2C8
3 positive regulation of interleukin-12 production GO:0032735 9.56 CD40LG CD40
4 positive regulation of interleukin-10 production GO:0032733 9.55 CD83 CD40LG
5 arachidonic acid metabolic process GO:0019369 9.54 CYP2C9 CYP2C8
6 B cell proliferation GO:0042100 9.52 CD40LG CD40
7 estrogen metabolic process GO:0008210 9.51 CYP2C9 CYP2C8
8 drug metabolic process GO:0017144 9.49 CYP2C9 CYP2C8
9 positive regulation of endothelial cell apoptotic process GO:2000353 9.48 CD40LG CD40
10 long-chain fatty acid biosynthetic process GO:0042759 9.46 CYP2C9 CYP2C8
11 exogenous drug catabolic process GO:0042738 9.43 CYP2C9 CYP2C8
12 organic acid metabolic process GO:0006082 9.4 CYP2C9 CYP2C8
13 epoxygenase P450 pathway GO:0019373 9.37 CYP2C9 CYP2C8
14 oxidative demethylation GO:0070989 9.32 CYP2C9 CYP2C8
15 omega-hydroxylase P450 pathway GO:0097267 9.26 CYP2C9 CYP2C8
16 CD40 signaling pathway GO:0023035 9.16 CD40LG CD40
17 regulation of immunoglobulin production GO:0002637 8.96 CD40LG CD40
18 icosanoid biosynthetic process GO:0046456 8.62 CYP2C9 CYP2C8

Molecular functions related to Sulfamethoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monooxygenase activity GO:0004497 9.4 CYP2C9 CYP2C8
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.37 CYP2C9 CYP2C8
3 steroid hydroxylase activity GO:0008395 9.32 CYP2C9 CYP2C8
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.26 CYP2C9 CYP2C8
5 aromatase activity GO:0070330 9.16 CYP2C9 CYP2C8
6 arachidonic acid epoxygenase activity GO:0008392 8.96 CYP2C9 CYP2C8
7 caffeine oxidase activity GO:0034875 8.62 CYP2C9 CYP2C8

Sources for Sulfamethoxazole Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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