MCID: SLF016
MIFTS: 24

Sulfonamide Allergy

Categories: Immune diseases

Aliases & Classifications for Sulfonamide Allergy

Summaries for Sulfonamide Allergy

Disease Ontology : 12 A drug allergy that has_allergic_trigger sulfonamide.

MalaCards based summary : Sulfonamide Allergy is related to angular cheilitis and lipodystrophy, familial partial, type 2. An important gene associated with Sulfonamide Allergy is GFPT2 (Glutamine-Fructose-6-Phosphate Transaminase 2), and among its related pathways/superpathways are Synthesis of substrates in N-glycan biosythesis and Serotonergic synapse. The drugs Celecoxib and Gabapentin have been mentioned in the context of this disorder. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Sulfonamide Allergy

Diseases related to Sulfonamide Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 angular cheilitis 9.9 GFPT1 GFPT2
2 lipodystrophy, familial partial, type 2 9.9 GFPT1 GFPT2
3 multiple chemical sensitivity 9.8 CYP2C9 CYP2D6
4 pancreatic steatorrhea 9.8 GFPT1 GFPT2
5 hepatitis d 9.8 CYP2C9 CYP2D6
6 drug-induced hepatitis 9.7 CYP2C9 CYP2D6

Graphical network of the top 20 diseases related to Sulfonamide Allergy:



Diseases related to Sulfonamide Allergy

Symptoms & Phenotypes for Sulfonamide Allergy

GenomeRNAi Phenotypes related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.32 CYP2D6
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.32 GFPT2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.32 CYP2D6
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.32 CYP2D6
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.32 CYP2D6 GFPT2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.32 CYP2D6
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.32 GFPT2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.32 CYP2D6
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.32 GFPT2

Drugs & Therapeutics for Sulfonamide Allergy

Drugs for Sulfonamide Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
2
Gabapentin Approved, Investigational Phase 4,Phase 2 60142-96-3 3446
3
Bupivacaine Approved, Investigational Phase 4,Phase 2 2180-92-9, 38396-39-3 2474
4
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
5
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
6
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
7
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
8
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 54677470 5281106
9
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
10
Desflurane Approved Phase 4 57041-67-5 42113
11
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
12 Analgesics, Non-Narcotic Phase 4,Phase 2
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
14 Neurotransmitter Agents Phase 4,Phase 2
15 Antiparkinson Agents Phase 4,Phase 2
16 Cyclooxygenase Inhibitors Phase 4,Phase 2
17 Central Nervous System Depressants Phase 4,Phase 2
18 Psychotropic Drugs Phase 4,Phase 2
19 Anesthetics, Local Phase 4,Phase 2
20 Cyclooxygenase 2 Inhibitors Phase 4,Phase 2
21 Excitatory Amino Acids Phase 4,Phase 2
22 Tranquilizing Agents Phase 4,Phase 2
23 calcium channel blockers Phase 4,Phase 2
24 Antirheumatic Agents Phase 4,Phase 2
25 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
26 Antimanic Agents Phase 4,Phase 2
27 Excitatory Amino Acid Antagonists Phase 4,Phase 2
28 Narcotics Phase 4,Phase 2
29 Anesthetics, Intravenous Phase 4,Phase 2
30 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
31 Anticonvulsants Phase 4,Phase 2
32 Analgesics Phase 4,Phase 2
33 Anesthetics Phase 4,Phase 2
34 Antipyretics Phase 4,Phase 2
35 Anesthetics, General Phase 4,Phase 2
36 Hypnotics and Sedatives Phase 4,Phase 2
37 Calcium, Dietary Phase 4,Phase 2
38 Analgesics, Opioid Phase 4,Phase 2
39 Anti-Anxiety Agents Phase 4,Phase 2
40 Anti-Arrhythmia Agents Phase 4
41 Ketorolac Tromethamine Phase 4
42 Cholinergic Antagonists Phase 4
43 Diuretics, Potassium Sparing Phase 4
44 Neuromuscular Nondepolarizing Agents Phase 4
45 Neuromuscular Blocking Agents Phase 4
46 Anesthetics, Inhalation Phase 4
47 Platelet Aggregation Inhibitors Phase 4
48 Sodium Channel Blockers Phase 4
49 Cholinergic Agents Phase 4
50 Neuromuscular Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Opioid-Free Shoulder Arthroplasty Active, not recruiting NCT03540030 Phase 4 Gabapentin;Celecoxib;toradol;acetaminophen;regional block;propofol;IV lidocaine;rocuronium;vecuronium;sevoflurane;desflurane
2 Antibiotic Prophylaxis in Children With Pyelonephritis Withdrawn NCT00752375 Phase 3 Trimethoprim Sulfamethoxazole;placebo
3 PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery Recruiting NCT03084536 Phase 2 Bupivacaine;Gabapentin;Celecoxib;Acetaminophen;Midazolam;Fentanyl
4 Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study) Recruiting NCT01560052 Not Applicable methylprednisolone;Placebo

Search NIH Clinical Center for Sulfonamide Allergy

Genetic Tests for Sulfonamide Allergy

Anatomical Context for Sulfonamide Allergy

Publications for Sulfonamide Allergy

Articles related to Sulfonamide Allergy:

# Title Authors Year
1
Desensitization to acetazolamide in a patient with previous antimicrobial sulfonamide allergy. ( 28089475 )
2017
2
Knowledge and attitudes of American pharmacists concerning sulfonamide allergy cross-reactivity. ( 20414726 )
2010
3
Ethacrynic acid as potential drug for diuretic renography in instance of sulfonamide allergy. ( 20548157 )
2010
4
Acetazolamide and sulfonamide allergy: a not so simple story. ( 21190500 )
2010
5
Sulfonamide allergy without cross-reactivity to celecoxib. ( 17156357 )
2007
6
Sulfonamide allergy and cross-reactivity. ( 17504660 )
2007
7
The management of patients with sulfonamide allergy. ( 3412290 )
1988
8
The Pathology of Sulfonamide Allergy in Man. ( 19970888 )
1946
9
The pathology of sulfonamide allergy in man. ( 20991973 )
1946
10
Sulfonamide Allergy. ( 18746741 )
1944

Variations for Sulfonamide Allergy

Expression for Sulfonamide Allergy

Search GEO for disease gene expression data for Sulfonamide Allergy.

Pathways for Sulfonamide Allergy

Pathways related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.78 GFPT1 GFPT2
2 11.54 CYP2C9 CYP2D6
3
Show member pathways
11.49 GFPT1 GFPT2
4
Show member pathways
11.37 CYP2C9 CYP2D6
5
Show member pathways
11.29 GFPT1 GFPT2
6 11.29 CYP2D6 GFPT1 GFPT2
7
Show member pathways
11.25 CYP2C9 CYP2D6
8
Show member pathways
11.18 CYP2C9 CYP2D6
9
Show member pathways
11.06 CYP2C9 CYP2D6
10
Show member pathways
10.75 CYP2C9 CYP2D6
11 10.5 GFPT1 GFPT2

GO Terms for Sulfonamide Allergy

Cellular components related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.62 CYP2C9 CYP2D6

Biological processes related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.57 CYP2C9 CYP2D6
2 xenobiotic metabolic process GO:0006805 9.56 CYP2C9 CYP2D6
3 protein N-linked glycosylation GO:0006487 9.55 GFPT1 GFPT2
4 drug metabolic process GO:0017144 9.54 CYP2C9 CYP2D6
5 exogenous drug catabolic process GO:0042738 9.52 CYP2C9 CYP2D6
6 organic acid metabolic process GO:0006082 9.51 CYP2C9 CYP2D6
7 glutamine metabolic process GO:0006541 9.49 GFPT1 GFPT2
8 long-chain fatty acid biosynthetic process GO:0042759 9.48 CYP2C9 CYP2D6
9 energy reserve metabolic process GO:0006112 9.46 GFPT1 GFPT2
10 UDP-N-acetylglucosamine biosynthetic process GO:0006048 9.43 GFPT1 GFPT2
11 oxidative demethylation GO:0070989 9.4 CYP2C9 CYP2D6
12 fructose 6-phosphate metabolic process GO:0006002 9.37 GFPT1 GFPT2
13 UDP-N-acetylglucosamine metabolic process GO:0006047 9.32 GFPT1 GFPT2
14 drug catabolic process GO:0042737 9.26 CYP2C9 CYP2D6
15 monoterpenoid metabolic process GO:0016098 9.16 CYP2C9 CYP2D6
16 carbohydrate derivative metabolic process GO:1901135 8.96 GFPT1 GFPT2
17 carbohydrate derivative biosynthetic process GO:1901137 8.62 GFPT1 GFPT2

Molecular functions related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.48 CYP2C9 CYP2D6
2 iron ion binding GO:0005506 9.46 CYP2C9 CYP2D6
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.43 CYP2C9 CYP2D6
4 drug binding GO:0008144 9.4 CYP2C9 CYP2D6
5 monooxygenase activity GO:0004497 9.37 CYP2C9 CYP2D6
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.32 CYP2C9 CYP2D6
7 steroid hydroxylase activity GO:0008395 9.26 CYP2C9 CYP2D6
8 transaminase activity GO:0008483 9.16 GFPT1 GFPT2
9 carbohydrate derivative binding GO:0097367 8.96 GFPT1 GFPT2
10 glutamine-fructose-6-phosphate transaminase (isomerizing) activity GO:0004360 8.62 GFPT1 GFPT2

Sources for Sulfonamide Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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