MCID: SLF016
MIFTS: 23

Sulfonamide Allergy

Categories: Immune diseases

Aliases & Classifications for Sulfonamide Allergy

MalaCards integrated aliases for Sulfonamide Allergy:

Name: Sulfonamide Allergy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040015
SNOMED-CT 67 91939003
UMLS 70 C0038757

Summaries for Sulfonamide Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger sulfonamide.

MalaCards based summary : Sulfonamide Allergy is related to severe cutaneous adverse reaction and erythema multiforme. An important gene associated with Sulfonamide Allergy is CA5A (Carbonic Anhydrase 5A), and among its related pathways/superpathways are Metabolism and Serotonergic synapse. Affiliated tissues include skin.

Related Diseases for Sulfonamide Allergy

Graphical network of the top 20 diseases related to Sulfonamide Allergy:



Diseases related to Sulfonamide Allergy

Symptoms & Phenotypes for Sulfonamide Allergy

Drugs & Therapeutics for Sulfonamide Allergy

Search Clinical Trials , NIH Clinical Center for Sulfonamide Allergy

Genetic Tests for Sulfonamide Allergy

Anatomical Context for Sulfonamide Allergy

MalaCards organs/tissues related to Sulfonamide Allergy:

40
Skin

Publications for Sulfonamide Allergy

Articles related to Sulfonamide Allergy:

(show all 41)
# Title Authors PMID Year
1
Alternative pneumocystis prophylaxis in solid organ transplant recipients at two large transplant centers. 61
32894607 2021
2
Drug allergy is associated with the development of extraintestinal manifestations in patients with ulcerative colitis. 61
31594293 2020
3
Sulfonamide desensitization in solid organ transplant recipients: A protocol-driven approach during the index transplant hospitalization. 61
31596538 2019
4
Sulfonamide Allergies. 61
31514363 2019
5
Beta-Lactam and Sulfonamide Allergy Testing Should Be a Standard of Care in Immunocompromised Hosts. 61
31253580 2019
6
"Doctor, I have a Sulfa Allergy": Clarifying the Myths of Cross-Reactivity. 61
29959752 2018
7
Dapsone safety in hematology patients: Pathways to optimizing Pneumocystis jirovecii pneumonia prophylaxis in hematology malignancy and transplant recipients. 61
30030892 2018
8
Sulfonamide Drug Allergy. 61
29876667 2018
9
Desensitization to acetazolamide in a patient with previous antimicrobial sulfonamide allergy. 61
28089475 2017
10
[«Sulfonamide allergy» - which drugs must patients avoid?]. 61
27272369 2016
11
Implementation of a diuretic stewardship program in a pediatric cardiovascular intensive care unit to reduce medication expenditures. 61
26025996 2015
12
Skin rash induced by ritonavir-boosted darunavir is common, but generally tolerable in an observational setting. 61
24507978 2014
13
An evidence-based approach for providing cautionary recommendations to sulfonamide-allergic patients and determining cross-reactivity among sulfonamide-containing medications. 61
23489131 2013
14
[Sulfonamide allergy and cross-reactivity]. 61
23667968 2013
15
Successful treatment of cerebral toxoplasmosis with clindamycin: a case report. 61
23074553 2012
16
Ethacrynic acid as potential drug for diuretic renography in instance of sulfonamide allergy. 61
20548157 2010
17
Knowledge and attitudes of American pharmacists concerning sulfonamide allergy cross-reactivity. 61
20414726 2010
18
Acetazolamide and sulfonamide allergy: a not so simple story. 61
21190500 2010
19
Sulfonamide allergy and cross-reactivity. 61
17504660 2007
20
Sulfonamide allergy without cross-reactivity to celecoxib. 61
17156357 2007
21
The sulfone syndrome secondary to dapsone prophylaxis in a patient undergoing unrelated hematopoietic stem cell transplantation. 61
16639690 2006
22
Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature. 61
15927910 2005
23
Sulfonamide cross-reactivity: fact or fiction? 61
15644481 2005
24
Leukocytoclastic vasculitis induced by use of glyburide: a case of possible cross-reaction of a sulfonamide and a sulfonylurea. 61
12661752 2003
25
Identification of sulfonamide-like adverse drug reactions to celecoxib in the World Health Organization database. 61
11900314 2001
26
Inhaled furosemide in the treatment of acute exacerbations of asthma 61
11015263 2000
27
Amprenavir: a new human immunodeficiency virus type 1 protease inhibitor. 61
10868554 2000
28
Antibiotic allergy in systemic lupus erythematosus: a case-control study. 61
1629825 1992
29
Allergic manifestations of human immunodeficiency virus (HIV) infection. 61
1676034 1991
30
[Encephalic toxoplasmosis in patients with the acquired immunodeficiency syndrome. A clinico-radiological study and the therapeutic results in 78 cases]. 61
2084411 1990
31
Isospora belli infection: treatment with pyrimethamine. 61
3261956 1988
32
The management of patients with sulfonamide allergy. 61
3412290 1988
33
Trimethoprim-sulfamethoxazole for acute dysuria in women: a single-dose or 10-day course. A double-blind, randomized trial. 61
3257670 1988
34
Therapeutic equivalence of sulfaisodimidine 2 g twice daily and 1 g four times daily in lower urinary tract infections. 61
7051761 1982
35
Spontaneous formation of immunogenic conjugates by a biotransformation product of sulfanilamide. 61
6796976 1981
36
[Detection of sulfonamide allergy by means in vivo tests]. 61
4789830 1973
37
[On the causes of sulfonamide allergy of the skin]. 61
13819624 1960
38
[Sulfonamide allergy]. 61
12993468 1952
39
The pathology of sulfonamide allergy in man. 61
20991973 1946
40
The Pathology of Sulfonamide Allergy in Man. 61
19970888 1946
41
Sulfonamide Allergy. 61
18746741 1944

Variations for Sulfonamide Allergy

Expression for Sulfonamide Allergy

Search GEO for disease gene expression data for Sulfonamide Allergy.

Pathways for Sulfonamide Allergy

Pathways related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.59 G6PD CYP2D6 CYP2C9 CA8 CA5B CA5A
2 11.57 CYP2D6 CYP2C9
3
Show member pathways
11.55 CYP2D6 CYP2C9
4
Show member pathways
11.52 CYP2D6 CYP2C9
5
Show member pathways
11.24 CYP2D6 CYP2C9
6
Show member pathways
11.2 CYP2D6 CYP2C9
7
Show member pathways
11.08 CYP2D6 CYP2C9
8
Show member pathways
10.91 CYP2D6 CYP2C9
9
Show member pathways
10.8 CYP2D6 CYP2C9
10
Show member pathways
10.69 CYP2D6 CYP2C9
11
Show member pathways
10.26 CA8 CA5B CA5A
12
Show member pathways
10 CYP2D6 CYP2C9

GO Terms for Sulfonamide Allergy

Cellular components related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.62 CYP2D6 CYP2C9

Biological processes related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.71 G6PD CYP2D6 CYP2C9
2 steroid metabolic process GO:0008202 9.55 CYP2D6 CYP2C9
3 cholesterol metabolic process GO:0008203 9.52 CYP2D6 CYP2C9
4 xenobiotic metabolic process GO:0006805 9.51 CYP2D6 CYP2C9
5 bicarbonate transport GO:0015701 9.49 CA5B CA5A
6 arachidonic acid metabolic process GO:0019369 9.48 CYP2D6 CYP2C9
7 estrogen metabolic process GO:0008210 9.46 CYP2D6 CYP2C9
8 drug metabolic process GO:0017144 9.43 CYP2D6 CYP2C9
9 long-chain fatty acid biosynthetic process GO:0042759 9.4 CYP2D6 CYP2C9
10 exogenous drug catabolic process GO:0042738 9.37 CYP2D6 CYP2C9
11 organic acid metabolic process GO:0006082 9.32 CYP2D6 CYP2C9
12 oxidative demethylation GO:0070989 9.26 CYP2D6 CYP2C9
13 drug catabolic process GO:0042737 9.16 CYP2D6 CYP2C9
14 monoterpenoid metabolic process GO:0016098 8.96 CYP2D6 CYP2C9
15 one-carbon metabolic process GO:0006730 8.8 CA8 CA5B CA5A

Molecular functions related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.58 G6PD CYP2D6 CYP2C9
2 monooxygenase activity GO:0004497 9.37 CYP2D6 CYP2C9
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.32 CYP2D6 CYP2C9
4 steroid hydroxylase activity GO:0008395 9.26 CYP2D6 CYP2C9
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.16 CYP2D6 CYP2C9
6 hydro-lyase activity GO:0016836 9.13 CA8 CA5B CA5A
7 carbonate dehydratase activity GO:0004089 8.8 CA8 CA5B CA5A

Sources for Sulfonamide Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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