MCID: SLF016
MIFTS: 31

Sulfonamide Allergy

Categories: Immune diseases

Aliases & Classifications for Sulfonamide Allergy

Summaries for Sulfonamide Allergy

Disease Ontology : 12 A drug allergy that has_allergic_trigger sulfonamide.

MalaCards based summary : Sulfonamide Allergy is related to angular cheilitis and lipodystrophy, familial partial, type 2. An important gene associated with Sulfonamide Allergy is GFPT2 (Glutamine-Fructose-6-Phosphate Transaminase 2), and among its related pathways/superpathways are Synthesis of substrates in N-glycan biosythesis and Serotonergic synapse. The drugs Celecoxib and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Sulfonamide Allergy

Diseases related to Sulfonamide Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 6, show less)
# Related Disease Score Top Affiliating Genes
1 angular cheilitis 9.9 GFPT1 GFPT2
2 lipodystrophy, familial partial, type 2 9.8 GFPT1 GFPT2
3 multiple chemical sensitivity 9.7 CYP2C9 CYP2D6
4 pancreatic steatorrhea 9.7 GFPT1 GFPT2
5 hepatitis d 9.7 CYP2C9 CYP2D6
6 drug-induced hepatitis 9.5 CYP2C9 CYP2D6

Graphical network of the top 20 diseases related to Sulfonamide Allergy:



Diseases related to Sulfonamide Allergy

Symptoms & Phenotypes for Sulfonamide Allergy

GenomeRNAi Phenotypes related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

27 (showing 9, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.32 CYP2D6
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.32 GFPT2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.32 CYP2D6
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.32 CYP2D6
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.32 CYP2D6 GFPT2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.32 CYP2D6
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.32 GFPT2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.32 CYP2D6
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.32 GFPT2

Drugs & Therapeutics for Sulfonamide Allergy

Drugs for Sulfonamide Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 92, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
2
Gabapentin Approved, Investigational Phase 4,Phase 2 60142-96-3 3446
3
Bupivacaine Approved, Investigational Phase 4,Phase 2 38396-39-3, 2180-92-9 2474
4
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
5
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
6
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
7
Desflurane Approved Phase 4 57041-67-5 42113
8
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
9
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 54677470 5281106
10
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
11
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
12 Anti-Anxiety Agents Phase 4,Phase 2
13 Narcotics Phase 4,Phase 2
14 Neurotransmitter Agents Phase 4,Phase 2
15 Anesthetics, Intravenous Phase 4,Phase 2
16 Analgesics Phase 4,Phase 2
17 Analgesics, Non-Narcotic Phase 4,Phase 2
18 Hypnotics and Sedatives Phase 4,Phase 2
19 Central Nervous System Depressants Phase 4,Phase 2
20 Excitatory Amino Acid Antagonists Phase 4,Phase 2
21 Psychotropic Drugs Phase 4,Phase 2
22 Anesthetics Phase 4,Phase 2
23 Cyclooxygenase 2 Inhibitors Phase 4,Phase 2
24 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
25 Antirheumatic Agents Phase 4,Phase 2
26 Anesthetics, Local Phase 4,Phase 2
27 Tranquilizing Agents Phase 4,Phase 2
28 Antimanic Agents Phase 4,Phase 2
29 Antipyretics Phase 4,Phase 2
30 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
31 Cyclooxygenase Inhibitors Phase 4,Phase 2
32 Anticonvulsants Phase 4,Phase 2
33 Analgesics, Opioid Phase 4,Phase 2
34 Excitatory Amino Acids Phase 4,Phase 2
35 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
36 Anesthetics, General Phase 4,Phase 2
37 Sodium Channel Blockers Phase 4
38 Cholinergic Antagonists Phase 4
39 Neuromuscular Nondepolarizing Agents Phase 4
40 Anti-Arrhythmia Agents Phase 4
41 Bromides Phase 4
42 Ketorolac Tromethamine Phase 4
43 Anesthetics, Inhalation Phase 4
44 Neuromuscular Agents Phase 4
45 Diuretics, Potassium Sparing Phase 4
46 Neuromuscular Blocking Agents Phase 4
47 Cholinergic Agents Phase 4
48 Vecuronium Bromide Phase 4 50700-72-6
49 Platelet Aggregation Inhibitors Phase 4
50
leucovorin Approved Phase 3,Not Applicable 58-05-9 143 6006
51
Sulfamethoxazole Approved Phase 3,Not Applicable 723-46-6 5329
52
Trimethoprim Approved, Vet_approved Phase 3,Not Applicable 738-70-5 5578
53
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Not Applicable 59-30-3 6037
54 Antiprotozoal Agents Phase 3,Not Applicable
55 Cytochrome P-450 Enzyme Inhibitors Phase 3,Not Applicable
56 Antimalarials Phase 3,Not Applicable
57 Vitamin B9 Phase 3,Not Applicable
58 Folate Phase 3,Not Applicable
59 Folic Acid Antagonists Phase 3,Not Applicable
60 Anti-Infective Agents, Urinary Phase 3,Not Applicable
61 Anti-Infective Agents Phase 3,Not Applicable
62 Vitamin B Complex Phase 3,Not Applicable
63 Antiparasitic Agents Phase 3,Not Applicable
64 Renal Agents Phase 3,Not Applicable
65
Naproxen Approved, Vet_approved Phase 2 22204-53-1 156391 1302
66
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
67
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
68 Pharmaceutical Solutions Phase 2
69 GABA Modulators Phase 2
70 GABA Agents Phase 2
71 Adjuvants, Anesthesia Phase 2
72
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
73
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
74
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
75
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
76
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
77
protease inhibitors Not Applicable
78 HIV Protease Inhibitors Not Applicable
79 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
80 Neuroprotective Agents Not Applicable
81 Hormones Not Applicable
82 Antiemetics Not Applicable
83 Hormone Antagonists Not Applicable
84 Autonomic Agents Not Applicable
85 Gastrointestinal Agents Not Applicable
86 Angiotensin-Converting Enzyme Inhibitors Not Applicable
87 Immunoglobulin A Not Applicable
88 Prednisolone acetate Not Applicable
89 Antineoplastic Agents, Hormonal Not Applicable
90 glucocorticoids Not Applicable
91 Protective Agents Not Applicable
92 Methylprednisolone Acetate Not Applicable

Interventional clinical trials:

(showing 4, show less)
# Name Status NCT ID Phase Drugs
1 Opioid-Free Shoulder Arthroplasty Active, not recruiting NCT03540030 Phase 4 Gabapentin;Celecoxib;toradol;acetaminophen;regional block;propofol;IV lidocaine;rocuronium;vecuronium;sevoflurane;desflurane
2 Antibiotic Prophylaxis in Children With Pyelonephritis Withdrawn NCT00752375 Phase 3 Trimethoprim Sulfamethoxazole;placebo
3 PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery Recruiting NCT03084536 Phase 2 Bupivacaine;Gabapentin;Celecoxib;Acetaminophen;Midazolam;Fentanyl
4 Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study) Recruiting NCT01560052 Not Applicable methylprednisolone;Placebo

Search NIH Clinical Center for Sulfonamide Allergy

Genetic Tests for Sulfonamide Allergy

Anatomical Context for Sulfonamide Allergy

MalaCards organs/tissues related to Sulfonamide Allergy:

42
Testes

Publications for Sulfonamide Allergy

Articles related to Sulfonamide Allergy:

(showing 10, show less)
# Title Authors Year
1
Desensitization to acetazolamide in a patient with previous antimicrobial sulfonamide allergy. ( 28089475 )
2017
2
Knowledge and attitudes of American pharmacists concerning sulfonamide allergy cross-reactivity. ( 20414726 )
2010
3
Ethacrynic acid as potential drug for diuretic renography in instance of sulfonamide allergy. ( 20548157 )
2010
4
Acetazolamide and sulfonamide allergy: a not so simple story. ( 21190500 )
2010
5
Sulfonamide allergy without cross-reactivity to celecoxib. ( 17156357 )
2007
6
Sulfonamide allergy and cross-reactivity. ( 17504660 )
2007
7
The management of patients with sulfonamide allergy. ( 3412290 )
1988
8
The Pathology of Sulfonamide Allergy in Man. ( 19970888 )
1946
9
The pathology of sulfonamide allergy in man. ( 20991973 )
1946
10
Sulfonamide Allergy. ( 18746741 )
1944

Variations for Sulfonamide Allergy

Expression for Sulfonamide Allergy

Search GEO for disease gene expression data for Sulfonamide Allergy.

Pathways for Sulfonamide Allergy

Pathways related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

(showing 10, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.77 GFPT1 GFPT2
2 11.52 CYP2C9 CYP2D6
3
Show member pathways
11.47 GFPT1 GFPT2
4
Show member pathways
11.46 CYP2C9 CYP2D6
5
Show member pathways
11.45 CYP2C9 CYP2D6
6 11.29 CYP2D6 GFPT1 GFPT2
7
Show member pathways
11.25 GFPT1 GFPT2
8
Show member pathways
11.06 CYP2C9 CYP2D6
9
Show member pathways
10.75 CYP2C9 CYP2D6
10 10.51 GFPT1 GFPT2

GO Terms for Sulfonamide Allergy

Cellular components related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.62 CYP2C9 CYP2D6

Biological processes related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

(showing 17, show less)
# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.57 CYP2C9 CYP2D6
2 xenobiotic metabolic process GO:0006805 9.56 CYP2C9 CYP2D6
3 protein N-linked glycosylation GO:0006487 9.55 GFPT1 GFPT2
4 drug metabolic process GO:0017144 9.54 CYP2C9 CYP2D6
5 exogenous drug catabolic process GO:0042738 9.52 CYP2C9 CYP2D6
6 organic acid metabolic process GO:0006082 9.51 CYP2C9 CYP2D6
7 glutamine metabolic process GO:0006541 9.49 GFPT1 GFPT2
8 long-chain fatty acid biosynthetic process GO:0042759 9.48 CYP2C9 CYP2D6
9 energy reserve metabolic process GO:0006112 9.46 GFPT1 GFPT2
10 UDP-N-acetylglucosamine biosynthetic process GO:0006048 9.43 GFPT1 GFPT2
11 oxidative demethylation GO:0070989 9.4 CYP2C9 CYP2D6
12 fructose 6-phosphate metabolic process GO:0006002 9.37 GFPT1 GFPT2
13 UDP-N-acetylglucosamine metabolic process GO:0006047 9.32 GFPT1 GFPT2
14 drug catabolic process GO:0042737 9.26 CYP2C9 CYP2D6
15 monoterpenoid metabolic process GO:0016098 9.16 CYP2C9 CYP2D6
16 carbohydrate derivative metabolic process GO:1901135 8.96 GFPT1 GFPT2
17 carbohydrate derivative biosynthetic process GO:1901137 8.62 GFPT1 GFPT2

Molecular functions related to Sulfonamide Allergy according to GeneCards Suite gene sharing:

(showing 10, show less)
# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.48 CYP2C9 CYP2D6
2 iron ion binding GO:0005506 9.46 CYP2C9 CYP2D6
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.43 CYP2C9 CYP2D6
4 drug binding GO:0008144 9.4 CYP2C9 CYP2D6
5 monooxygenase activity GO:0004497 9.37 CYP2C9 CYP2D6
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.32 CYP2C9 CYP2D6
7 steroid hydroxylase activity GO:0008395 9.26 CYP2C9 CYP2D6
8 transaminase activity GO:0008483 9.16 GFPT1 GFPT2
9 carbohydrate derivative binding GO:0097367 8.96 GFPT1 GFPT2
10 glutamine-fructose-6-phosphate transaminase (isomerizing) activity GO:0004360 8.62 GFPT1 GFPT2

Sources for Sulfonamide Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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