MCID: SNC001
MIFTS: 29

Sunct Headache

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Sunct Headache

MalaCards integrated aliases for Sunct Headache:

Name: Sunct Headache 52 53
Sunct Syndrome 52 58 71
Short-Lasting, Unilateral, Neuralgiform Headache Attacks with Conjunctival Injection and Tearing 52
Short-Lasting Unilateral Neuralgiform Headache Attacks with Conjunctival Injection and Tearing 58

Characteristics:

Orphanet epidemiological data:

58
sunct syndrome
Prevalence: 1-9/100000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

MESH via Orphanet 44 D050798
ICD10 via Orphanet 33 G44.8
UMLS via Orphanet 72 C1262087
Orphanet 58 ORPHA57145
UMLS 71 C1262087

Summaries for Sunct Headache

NINDS : 53 SUNCT-Short-lasting, Unilateral, Neuralgiform headache attacks with Conjunctival injection and Tearing-is a rare form of headache that is most common in men after age 50. The disorder is marked by bursts of moderate to severe burning, piercing, or throbbing pain, usually on one side of the head and around the eye or temple. The pain usually peaks within seconds of onset and may follow a pattern of increasing and decreasing intensity.  Attacks typically occur in daytime hours and last from 5 seconds to 4 minutes per episode. Individuals generally have five to six attacks per hour. Autonomic nervous system responses include watery eyes, reddish or bloodshot eyes caused by dilation of blood vessels (conjunctival injection), nasal congestion, runny nose, sweaty forehead, swelling of the eyelids, and increased pressure within the eye on the affected side of head. Systolic blood pressure may rise during the attacks. Movement of the neck may trigger these headaches. SUNCT may be a form of trigeminal neuralgia and is considered one of the trigeminal autonomic cephalgias, or TACs.

MalaCards based summary : Sunct Headache, also known as sunct syndrome, is related to trigeminal neuralgia and migraine with or without aura 1. Affiliated tissues include eye, brain and pituitary, and related phenotypes are conjunctival hyperemia and episodic pain

Wikipedia : 74 Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT syndrome),... more...

Related Diseases for Sunct Headache

Diseases related to Sunct Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 trigeminal neuralgia 10.7
2 migraine with or without aura 1 10.5
3 pituitary adenoma, prolactin-secreting 10.5
4 severe cutaneous adverse reaction 10.5
5 erythema multiforme 10.5
6 telangiectasis 10.5
7 pituitary adenoma 10.5
8 growth hormone secreting pituitary adenoma 10.5
9 adenoma 10.5
10 paroxysmal hemicrania 10.5
11 short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms 10.5
12 trigeminal autonomic cephalalgia 10.5
13 erythema multiforme major 10.5
14 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.5
15 rare headache 10.5
16 cluster headache 10.5
17 headache 10.3
18 ptosis 10.3
19 chickenpox 10.2
20 hemicrania continua 10.2
21 anisocoria 10.1
22 meningioma, radiation-induced 10.1
23 meningioma, familial 10.1
24 exanthem 10.1
25 meningoencephalitis 10.1
26 spinal meningioma 10.1
27 secretory meningioma 10.1
28 lymphoplasmacyte-rich meningioma 10.1
29 cerebellopontine angle meningioma 10.1
30 47,xyy 10.1
31 stroke, ischemic 10.0
32 brittle bone disorder 10.0
33 cerebellar hypoplasia 10.0
34 viral meningitis 10.0
35 horner's syndrome 10.0
36 tolosa-hunt syndrome 10.0
37 dermatitis 10.0
38 lateral medullary syndrome 10.0
39 herpes zoster 10.0
40 seborrheic dermatitis 10.0
41 ocular hypertension 10.0
42 meningitis 10.0
43 herpes zoster ophthalmicus 10.0
44 hypnic headache 10.0
45 aneurysm 10.0
46 pituitary tumors 10.0

Graphical network of the top 20 diseases related to Sunct Headache:



Diseases related to Sunct Headache

Symptoms & Phenotypes for Sunct Headache

Human phenotypes related to Sunct Headache:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 conjunctival hyperemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0030953
2 episodic pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0032148
3 ptosis 58 31 frequent (33%) Frequent (79-30%) HP:0000508
4 migraine 58 31 frequent (33%) Frequent (79-30%) HP:0002076
5 trigeminal neuralgia 58 31 frequent (33%) Frequent (79-30%) HP:0100661
6 agitation 58 31 frequent (33%) Frequent (79-30%) HP:0000713
7 rhinorrhea 58 31 frequent (33%) Frequent (79-30%) HP:0031417
8 episodic hyperhidrosis 58 31 frequent (33%) Frequent (79-30%) HP:0001069
9 flushing 58 31 frequent (33%) Frequent (79-30%) HP:0031284
10 increased tear production 58 31 frequent (33%) Frequent (79-30%) HP:0031731
11 photophobia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000613
12 palpebral edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0100540
13 miosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000616
14 nausea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002018
15 nasal obstruction 58 31 occasional (7.5%) Occasional (29-5%) HP:0001742
16 facial erythema 58 31 occasional (7.5%) Occasional (29-5%) HP:0001041
17 ear pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0030766
18 jaw pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0040264
19 vomiting 58 31 very rare (1%) Very rare (<4-1%) HP:0002013
20 hyperhidrosis 58 Frequent (79-30%)
21 restlessness 58 Frequent (79-30%)
22 facial edema 58 Occasional (29-5%)
23 epiphora 58 Very frequent (99-80%)

Drugs & Therapeutics for Sunct Headache

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders Unknown status NCT01842763

Search NIH Clinical Center for Sunct Headache

Genetic Tests for Sunct Headache

Anatomical Context for Sunct Headache

MalaCards organs/tissues related to Sunct Headache:

40
Eye, Brain, Pituitary, Hypothalamus, Heart

Publications for Sunct Headache

Articles related to Sunct Headache:

(show top 50) (show all 176)
# Title Authors PMID Year
1
SUNCT Headache Occurring Secondary to a Cerebellopontine Angle Meningioma Reinforces the Hypothesis of Trigeminal Nerve Compression. 61
32330271 2020
2
Comorbid SUNCT Syndrome and Opalski Syndrome Caused by Dorsolateral Medullary Infarction. 61
32117015 2020
3
Gamma Knife Radiosurgery for Short Unilateral Neuralgiform Headache Attacks with Conjunctival Injection and Tearing (SUNCT) Syndrome: Targeting the Trigeminal Nerve and the Sphenopalatine Ganglion. Case Report and Literature Review. 61
31606507 2020
4
SUNCT Syndrome Secondary to Expanding Prolactinoma Responsive to Lamotrigine - A Case Report. 61
31373678 2019
5
The "Cluster-SUNCT Syndrome": The Lumper-Splitter Problem. 61
30107598 2019
6
SUNCT Headache Attacks Associated With Reactivation of Varicella Zoster Virus in a Trigeminal Distribution. 61
30446992 2019
7
Classification of Trigeminal Autonomic Cephalalgia: What has Changed in International Classification of Headache Disorders-3 Beta? 61
29720818 2018
8
Post herpes zoster SUNCT like syndrome: Insights from two case reports. 61
27799443 2018
9
A case of secondary SUNCT syndrome. 61
29870628 2017
10
SUNCT syndrome: A cohort of 15 Portuguese patients. 61
26611683 2016
11
Herpes Zoster Ophthalmicus That Mimics the SUNCT Syndrome. 61
28360795 2016
12
Secondary SUNCT syndrome caused by dorsolateral medullary infarction. 61
26885826 2016
13
Botulinum Toxin A for the Treatment of a Child with SUNCT Syndrome. 61
27445629 2016
14
Pathogenesis, Surgical Treatment, and Cure for SUNCT Syndrome. 61
26008143 2015
15
Sunct syndrome. Report of a case and treatment update. 61
26155359 2015
16
[Trigeminal autonomic cephalgias]. 61
27030837 2015
17
Complete alleviation of treatment refractory primary SUNCT syndrome with clomiphene citrate (a medicinal deep brain hypothalamic modulator). 61
24662321 2014
18
[Therapy of trigeminal autonomic headaches]. 61
25005009 2014
19
The effect of posterior hypothalamus region deep brain stimulation on sleep. 61
24045569 2014
20
[Update on trigeminal autonomic cephalalgia]. 61
24212418 2013
21
Complete remission of SUNCT syndrome by intravenous glucocorticoid treatment. 61
23274832 2013
22
Frameless linac-based stereotactic radiosurgery treatment for SUNCT syndrome targeting the trigeminal nerve and sphenopalatine ganglion. 61
23624340 2013
23
Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing caused by a pituitary adenoma. 61
23664408 2013
24
SUNCT syndrome findings accompanied by cavernous segment aneurysm. 61
22846116 2013
25
Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome secondary to an epidermoid tumor in the cerebellopontine angle. 61
23452266 2013
26
[Trigeminal autonomic cephalgias - new aspects and concepts]. 61
22915385 2012
27
Orofacial pain due to trigeminal autonomic cephalgia with features of short-lasting neuralgiform headache attacks with conjunctival injection and tearing: a case report. 61
22771218 2012
28
Sustained response to botulinum toxin in SUNCT syndrome. 61
22734103 2012
29
SUNCT syndrome treated with gamma knife targeting the trigeminal nerve and sphenopalatine ganglion. 61
22684526 2012
30
Whiplash injury-induced atypical short-lasting unilateral neuralgiform headache with conjunctival injection and tearing syndrome treated by greater occipital nerve block. 61
22330130 2012
31
Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) with preserved refractory period: report of three cases. 61
22227716 2012
32
[Paroxysmal hemicrania and SUNCT]. 61
22120922 2011
33
Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) secondary to epidermoid cyst in the right cerebellopontine angle successfully treated with surgery. 61
21409598 2011
34
SUNCT syndrome successfully treated by gamma knife radiosurgery: case report. 61
21478230 2011
35
A case of SUNCT syndrome responsive to zonisamide. 61
21036860 2011
36
The role of lamotrigine in the treatment of short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome. 61
21189366 2011
37
Microvascular decompression of the trigeminal nerve in the treatment of SUNCT and SUNA. 61
20462914 2010
38
Meningioma causing gabapentin-responsive secondary SUNCT syndrome. 61
20428918 2010
39
SUNCT syndrome with paroxysmal mydriasis: Clinical and pupillometric findings. 61
20656711 2010
40
Methylprednisolone therapy for short-term prevention of SUNCT syndrome. 61
19673911 2010
41
Deep brain stimulation in trigeminal autonomic cephalalgias. 61
20430322 2010
42
Temporal response to bupivacaine bilateral great occipital block in a patient with SUNCT syndrome. 61
20232223 2010
43
Response to intravenous lidocaine in a patient with SUNCT syndrome. 61
19438923 2010
44
A case of ocular hypertension complicated by SUNCT syndrome. 61
21138147 2010
45
Bilateral SUNCT-like headache in a patient with prolactinoma responsive to lamotrigine. 61
19763771 2009
46
SUNCT syndrome or first division trigeminal neuralgia associated with cerebellar hypoplasia. 61
19760043 2009
47
SUNCT syndrome successfully treated with the combination of oxcarbazepine and gabapentin. 61
19863743 2009
48
[The hypothalamus in SUNCT syndrome: similarities and differences with the other trigeminal-autonomic cephalalgias]. 61
19728278 2009
49
Attack-related brainstem activation in a patient with SUNCT syndrome: an ictal fMRI study. 61
19220497 2009
50
Secondary SUNCT syndrome caused by viral meningitis. 61
19444540 2009

Variations for Sunct Headache

Expression for Sunct Headache

Search GEO for disease gene expression data for Sunct Headache.

Pathways for Sunct Headache

GO Terms for Sunct Headache

Sources for Sunct Headache

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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