MCID: SPR019
MIFTS: 23

Superficial Keratitis

Categories: Eye diseases

Aliases & Classifications for Superficial Keratitis

MalaCards integrated aliases for Superficial Keratitis:

Name: Superficial Keratitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12196
ICD9CM 34 370.20
SNOMED-CT 67 27019000
ICD10 32 H16.10
UMLS 71 C0155074

Summaries for Superficial Keratitis

MalaCards based summary : Superficial Keratitis is related to dry eye syndrome and philophthalmiasis. An important gene associated with Superficial Keratitis is CD44 (CD44 Molecule (Indian Blood Group)). Affiliated tissues include eye, retina and testes.

Related Diseases for Superficial Keratitis

Diseases related to Superficial Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 dry eye syndrome 29.3 NGF LACRT CD44
2 philophthalmiasis 11.4
3 keratitis, hereditary 10.7
4 ocular hyperemia 10.3 PTGFR EVC2
5 serotonin syndrome 10.3 TAC1 IFNA2
6 prurigo nodularis 10.3 TAC1 NGF
7 detrusor sphincter dyssynergia 10.2 TAC1 NGF
8 cough variant asthma 10.2 TAC1 NGF
9 chronic cystitis 10.2 TAC1 NGF
10 trigeminal nerve disease 10.2 TAC1 NGF
11 mononeuropathy 10.2 TAC1 NGF
12 polyradiculopathy 10.2 TAC1 NGF
13 nerve compression syndrome 10.2 TAC1 NGF
14 burning mouth syndrome 10.2 TAC1 NGF
15 interval angle-closure glaucoma 10.2 TAC1 HLA-DQA1
16 sympathetic ophthalmia 10.1 HLA-DQA1 CD44
17 neurogenic bladder 10.1 TAC1 NGF
18 autonomic nervous system disease 10.1 TAC1 NGF
19 autoimmune disease 10.0
20 corneal disease 10.0
21 conjunctivitis 10.0
22 paine syndrome 10.0 TAC1 NGF
23 systemic lupus erythematosus 9.9
24 yemenite deaf-blind hypopigmentation syndrome 9.9
25 severe cutaneous adverse reaction 9.9
26 riboflavin deficiency 9.9
27 erythema multiforme 9.9
28 exanthem 9.9
29 corneal edema 9.9
30 chlamydia 9.9
31 allergic hypersensitivity disease 9.9
32 keratoconjunctivitis sicca 9.9
33 blepharospasm 9.9
34 eye disease 9.9
35 chickenpox 9.9
36 lupus erythematosus 9.9
37 pemphigus 9.9
38 keratoconjunctivitis 9.9
39 blepharitis 9.9
40 deep keratitis 9.9
41 erythema multiforme major 9.9
42 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.9
43 eyelid disease 9.8 SRCIN1 LACRT
44 corneal ulcer 9.7 NGF LACRT
45 onchocerciasis 9.7 SRCIN1 HLA-DQA1
46 keratopathy 9.6 TAC1 LACRT
47 punctate epithelial keratoconjunctivitis 8.7 TENT5D TAC1 SRCIN1 SBK1 PTGFR NGF

Graphical network of the top 20 diseases related to Superficial Keratitis:



Diseases related to Superficial Keratitis

Symptoms & Phenotypes for Superficial Keratitis

Drugs & Therapeutics for Superficial Keratitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of the Performance and Safety of T2259 Versus Vismed Multi in Dry Eye Patients With Superficial Keratitis. Recruiting NCT03874429

Search NIH Clinical Center for Superficial Keratitis

Genetic Tests for Superficial Keratitis

Anatomical Context for Superficial Keratitis

MalaCards organs/tissues related to Superficial Keratitis:

40
Eye, Retina, Testes, Endothelial

Publications for Superficial Keratitis

Articles related to Superficial Keratitis:

(show top 50) (show all 130)
# Title Authors PMID Year
1
Frontalis Linkage Without Intraoperative Eyelid Elevation for the Management of Myopathic Ptosis. 61
31809486 2019
2
Utility of HSV Serology for Chronic Corneal Pathology. 61
31306215 2019
3
A novel herpesvirus associated with chronic superficial keratitis and proliferative conjunctivitis in a great horned owl (Bubo virginianus). 61
29656541 2019
4
A diagnosis of Stevens-Johnson Syndrome (SJS) in a patient presenting with superficial keratitis. 61
30128368 2018
5
Punctal Plug as a Treatment Option for Dry Eye Associated with Congenital Supernumary Puncta. 61
30765958 2018
6
Evaluation of a new matrix regenerating agent in patients with Sjögren syndrome and superficial ulcerative keratitis resistant to conventional therapy: A report of 3 cases. 61
29517701 2018
7
Comparison of Efficacy and Ocular Surface Disease Index Score between Bimatoprost, Latanoprost, Travoprost, and Tafluprost in Glaucoma Patients. 61
29707390 2018
8
Use of Copaifera multijuga for acute corneal repair after chemical injury: A clinical, histopathological and toxicogenetic study. 61
29169733 2017
9
Heat Shock Proteins 70kDa, Eosinophil Cationic Protein, and Nitric Oxide During Chronic Superficial Keratitis in Dogs. 61
28750792 2017
10
Inheritance of chronic superficial keratitis in Australian Greyhounds. 61
27147552 2016
11
Mini-Review: Limbal Stem Cells Deficiency in Companion Animals: Time to Give Something Back? 61
26287764 2016
12
Dendritiform Keratopathy Associated with Exposure to Polyquarternium-1, a Common Ophthalmic Preservative. 61
26686962 2016
13
[Clinical analyses of 21 cases of Thygeson's superficial punctate keratitis]. 61
26268638 2015
14
Adjunctive cryotherapy for pigmentary keratitis in dogs: a study of 16 corneas. 61
23953431 2014
15
Serum vascular endothelial growth factor concentration in dogs diagnosed with chronic superficial keratitis. 61
24334076 2014
16
Non-contact lens use-related Acanthamoeba keratitis in southern Turkey: evaluation of risk factors and clinical features. 61
24030538 2014
17
A retrospective study of the occurrence of chronic superficial keratitis in 308 German Shepherd dogs: 1999-2010. 61
25286670 2014
18
A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1. 61
24238945 2013
19
Ocular manifestations of small-vessel vasculitis. 61
23203643 2012
20
Microsporidial keratitis: Literature review and report of 2 cases in a tertiary eye care center. 61
23960992 2012
21
Clinical study on the application of tacrolimus and DMSO in the treatment of chronic superficial keratitis in dogs. 61
23390756 2012
22
From dorzolamide 2%/timolol 0.5% to brinzolamide 1%/timolol 0.5% fixed combination: a 6-month, multicenter, open-label tolerability switch study. 61
21679090 2011
23
Adjuvant 5-fluorouracil in the treatment of localised ocular surface squamous neoplasia. 61
21252085 2011
24
Adenovirus advances: new diagnostic and therapeutic options. 61
21537185 2011
25
The effect of UV-blocking contact lenses as a therapy for canine chronic superficial keratitis. 61
21521443 2011
26
MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs. 61
21144596 2011
27
Primary central corneal hemangiosarcoma in a dog. 61
21366830 2011
28
Keratoprosthesis with retrocorneal fixation: preliminary results in dogs with corneal blindness. 61
20840104 2010
29
A keratoprosthesis prototype for the dog. 61
20149176 2010
30
Radiotherapy for canine chronic superficial keratitis using soft X-rays (15 kV). 61
20149171 2010
31
Penetrating keratoscleroplasty and bimodal grafting for treatment of limbal melanocytoma in a dog. 61
19046295 2008
32
Modulation of matrix metalloproteinases by ultraviolet radiation in the canine cornea. 61
18435653 2008
33
LASIK flap interface deposition in limbal vernal keratoconjunctivitis. 61
18271782 2008
34
[Applying the DNA diagnostics in patients with superficial keratitis of viral origin]. 61
18419101 2008
35
Immune-mediated canine and feline keratitis. 61
18299007 2008
36
Transcorneal electrical stimulation of retina to treat longstanding retinal artery occlusion. 61
17593383 2007
37
Archipelago keratitis: a clinical variant of recurrent herpetic keratitis? 61
17418418 2007
38
Acanthamoeba keratitis and contact lens wear. 61
17697181 2007
39
[Clinical forms of corneal abnormalities in atopic keratoconjunctivitis]. 61
18078059 2007
40
Histopathologic evidence of capecitabine corneal toxicity in dogs. 61
17846245 2007
41
[Treatment of ocular lesions due to Elapidae venom spitting in Central African Republic: epidemiological and clinical aspects]. 61
17727033 2007
42
Major histocompatibility class II expression in the normal canine cornea and in canine chronic superficial keratitis. 61
16359362 2005
43
An infant case of Graves' disease with ophthalmopathy. 61
16284447 2005
44
Efficacy and safety of 0.18% sodium hyaluronate in patients with moderate dry eye syndrome and superficial keratitis. 61
15965673 2005
45
A Korean case of Cornelia de Lange syndrome. 61
15988935 2005
46
Microsporidia: emerging ocular pathogens. 61
15928435 2005
47
[Pepper spray injuries of the anterior segment of the eye]. 61
15785998 2005
48
The effect of topical pimecrolimus on keratoconjunctivitis sicca and chronic superficial keratitis in dogs: results from an exploratory study. 61
15644099 2005
49
Trimethoprim-sulphamethoxazole therapy in Nocardia keratitis. 61
15281980 2004
50
In vivo confocal microscopy of Thygeson's superficial punctate keratitis. 61
15180847 2004

Variations for Superficial Keratitis

Expression for Superficial Keratitis

Search GEO for disease gene expression data for Superficial Keratitis.

Pathways for Superficial Keratitis

GO Terms for Superficial Keratitis

Biological processes related to Superficial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.26 PTGFR NGF LACRT CD44
2 inflammatory response GO:0006954 8.92 TAC1 PTGFR IFNA2 CD44

Sources for Superficial Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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