MCID: SPR020
MIFTS: 29

Superficial Mycosis

Categories: Infectious diseases

Aliases & Classifications for Superficial Mycosis

MalaCards integrated aliases for Superficial Mycosis:

Name: Superficial Mycosis 12 15 73
Piedra 12 44 73
Steroid-Modified Tinea Infection 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050133
ICD10 33 B36.9
MeSH 44 D010854

Summaries for Superficial Mycosis

Disease Ontology : 12 A fungal infectious disease that results in infection of the outermost layer located in skin or located in hair shaft, has material basis in Fungi. No living tissue is invaded and there is no cellular response from the host.

MalaCards based summary : Superficial Mycosis, also known as piedra, is related to pityriasis versicolor and black piedra. An important gene associated with Superficial Mycosis is TMC8 (Transmembrane Channel Like 8). The drugs Fluconazole and Micafungin have been mentioned in the context of this disorder. Affiliated tissues include skin or, skin and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 A dermatomycosis is a skin disease caused by a fungus. This excludes... more...

Related Diseases for Superficial Mycosis

Diseases related to Superficial Mycosis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pityriasis versicolor 29.0 KRT31 STIM1 TLR9 TMC6 TMC8
2 black piedra 11.3
3 white piedra 11.3
4 tinea nigra 11.3
5 tinea pedis 9.7
6 lichen planus 9.7
7 epidermodysplasia verruciformis 9.7 TMC6 TMC8

Graphical network of the top 20 diseases related to Superficial Mycosis:



Diseases related to Superficial Mycosis

Symptoms & Phenotypes for Superficial Mycosis

GenomeRNAi Phenotypes related to Superficial Mycosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.23 CBS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.23 CBS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.23 CBS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.23 CBS CIC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.23 CIC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.23 CIC
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.23 CIC

Drugs & Therapeutics for Superficial Mycosis

Drugs for Superficial Mycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
2
Micafungin Approved, Investigational Phase 3 235114-32-6 3081921 477468
3
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 1 22916-47-8 4189
4 Antifungal Agents Phase 3,Phase 1
5 Anti-Infective Agents Phase 3,Phase 1
6 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
7 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 1
8 Echinocandins Phase 3
9 Hormone Antagonists Phase 3,Phase 1
10 Hormones Phase 3,Phase 1
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
12 Liver Extracts Phase 3
13 Steroid Synthesis Inhibitors Phase 3,Phase 1
14
Itraconazole Approved, Investigational Phase 1 84625-61-6 55283
15 Cytochrome P-450 CYP3A Inhibitors Phase 1
16
Hydroxyitraconazole Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Micafungin Versus Fluconazole for Prevention of Invasive Fungal Disease in Living Donor Liver Transplant Recipients Unknown status NCT01974375 Phase 3 micafungin;Fluconazole
2 A Clinical Study to Evaluate the Pharmacokinetics of Lozanoc and Sporanox in Korean Healthy Male Volunteers Completed NCT02493738 Phase 1 Lozanoc 50mg;Sporanox 100mg

Search NIH Clinical Center for Superficial Mycosis

Cochrane evidence based reviews: piedra

Genetic Tests for Superficial Mycosis

Anatomical Context for Superficial Mycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Superficial Mycosis:

19
Skin Or

MalaCards organs/tissues related to Superficial Mycosis:

41
Skin, Liver

Publications for Superficial Mycosis

Articles related to Superficial Mycosis:

(show all 18)
# Title Authors Year
1
Superficial mycosis of the foot caused by Cladophialophora boppii. ( 29318642 )
2018
2
Investigation of superficial mycosis in cutaneous allergy patients using topical or systemic corticosteroids. ( 28593694 )
2017
3
White piedra, black piedra, tinea versicolor, and tinea nigra: contribution to the diagnosis of superficial mycosis. ( 29186263 )
2017
4
Generalized Superficial Mycosis Caused by Trichophyton raubitschekii in China: Case Report and Review of the Literature. ( 25502847 )
2015
5
Treatment of a superficial mycosis by low-temperature plasma: a case report. ( 24874937 )
2014
6
Superficial mycosis. ( 25742993 )
2014
7
Comparison of superficial mycosis treatment using Butenafine and Bifonazole nitrate clinical efficacy. ( 23283047 )
2013
8
Superficial mycosis and the immune response elements. ( 21987139 )
2011
9
Study to compare the efficacy and safety of fluconazole cream with flutrimazole cream in the treatment of superficial mycosis: a multicentre, randomised, double-blind, phase III trial. ( 19558428 )
2010
10
Superficial mycosis of the breast caused by Curvularia inaequalis. ( 20627856 )
2010
11
Epidemiology of superficial mycosis (tinea pedis, onychomycosis) in elementary school children in Istanbul, Turkey. ( 16617585 )
2006
12
Clinico-mycological Profile of Superficial Mycosis in a Hospital in North-East India. ( 27407482 )
2003
13
Superficial mycosis superimposing on isolated lichen planus of the lip: a case report and review of the literature. ( 12080952 )
2002
14
Superficial mycosis in renal transplant recipients. ( 2053155 )
1991
15
Comparative study of miconazole and clotrimazole in superficial mycosis. ( 2632381 )
1989
16
Yeasts in superficial mycosis : pathogenicity of Candida species to Swiss albino mice. ( 1010625 )
1976
17
Superficial mycosis in children of the Dominican Republic. ( 127118 )
1975
18
Yeasts in superficial mycosis. I. Incidence, isolation and characterisation. ( 1213721 )
1975

Variations for Superficial Mycosis

Expression for Superficial Mycosis

Search GEO for disease gene expression data for Superficial Mycosis.

Pathways for Superficial Mycosis

GO Terms for Superficial Mycosis

Cellular components related to Superficial Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.26 STIM1 TLR9 TMC6 TMC8
2 endoplasmic reticulum membrane GO:0005789 8.92 STIM1 TLR9 TMC6 TMC8

Biological processes related to Superficial Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 8.8 STIM1 TMC6 TMC8

Molecular functions related to Superficial Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.23 BCLAF1 CBS CIC KRT31 STIM1 TLR9

Sources for Superficial Mycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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