Superficial Siderosis of the Central Nervous System disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPR032 MIFTS: 23	Superficial Siderosis of the Central Nervous System Categories: Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Superficial Siderosis of the Central Nervous System

MalaCards integrated aliases for Superficial Siderosis of the Central Nervous System:

Name: Superficial Siderosis of the Central Nervous System ⁵²

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

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Summaries for Superficial Siderosis of the Central Nervous System

NIH Rare Diseases : ⁵² Superficial siderosis of the central nervous system is a rare condition that primarily affects the brain. Signs and symptoms generally develop in adulthood and may include hearing loss and cerebellar ataxia . Some affected people may also experience seizures , memory impairment, bladder disturbance, headaches, back pain, and/or dysarthria . Superficial siderosis of the central nervous system is thought to be caused by bleeding into a portion of the brain called the subarachnoid space (the area between the brain and the thin tissues that cover the brain). This bleeding can have a variety of causes, such as trauma, a tumor of the central nervous system, arteriovenous malformations , or an unknown cause. Not all people who experience bleeding into the subarachnoid space go on to develop superficial siderosis of the central nervous system. Treatment varies based on the underlying cause and severity of the condition and may include surgery and/or medications.

MalaCards based summary : Superficial Siderosis of the Central Nervous System is related to superficial siderosis and siderosis. An important gene associated with Superficial Siderosis of the Central Nervous System is FTH1 (Ferritin Heavy Chain 1), and among its related pathways/superpathways are Insulin receptor recycling and Mineral absorption. Affiliated tissues include brain, pituitary and bone.

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Related Diseases for Superficial Siderosis of the Central Nervous System

Diseases related to Superficial Siderosis of the Central Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)

#	Related Disease	Score	Top Affiliating Genes
1	superficial siderosis	32.0	TF LTF FTH1
2	siderosis	30.5	TF LTF FTH1
3	aceruloplasminemia	29.9	LTF FTH1
4	hemochromatosis, type 1	29.9	TF FTH1
5	ataxia and polyneuropathy, adult-onset	11.0
6	ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	10.9
7	branchiootic syndrome 1	10.8
8	sensorineural hearing loss	10.8
9	benign ependymoma	10.6
10	cellular ependymoma	10.6
11	pathologic nystagmus	10.5
12	spastic paraparesis	10.4
13	cerebral amyloid angiopathy, cst3-related	10.4
14	neurofibromatosis, type iv, of riccardi	10.3
15	meningocele	10.3
16	hydrocephalus	10.3
17	arteriovenous malformation	10.3
18	visual epilepsy	10.3
19	hemosiderosis	10.3
20	neurogenic bladder	10.3
21	myxopapillary ependymoma	10.3
22	head injury	10.3
23	headache	10.3
24	seizure disorder	10.3
25	amyotrophic lateral sclerosis 1	10.1
26	medulloblastoma	10.1
27	neurofibromatosis, type i	10.1
28	scleroderma, familial progressive	10.1
29	congenital heart defects, hamartomas of tongue, and polysyndactyly	10.1
30	cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1	10.1
31	pituitary adenoma, prolactin-secreting	10.1
32	aphasia	10.1
33	thrombosis	10.1
34	meningoencephalitis	10.1
35	intracranial aneurysm	10.1
36	pituitary apoplexy	10.1
37	pyelonephritis	10.1
38	dementia	10.1
39	toxic shock syndrome	10.1
40	normal pressure hydrocephalus	10.1
41	impotence	10.1
42	optic nerve disease	10.1
43	melanoma	10.1
44	exostosis	10.1
45	lateral sclerosis	10.1
46	astrocytoma	10.1
47	neurilemmoma	10.1
48	craniopharyngioma	10.1
49	papillary craniopharyngioma	10.1
50	meningeal melanocytoma	10.1

Graphical network of the top 20 diseases related to Superficial Siderosis of the Central Nervous System:

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Symptoms & Phenotypes for Superficial Siderosis of the Central Nervous System

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Drugs & Therapeutics for Superficial Siderosis of the Central Nervous System

Search Clinical Trials , NIH Clinical Center for Superficial Siderosis of the Central Nervous System

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Genetic Tests for Superficial Siderosis of the Central Nervous System

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Anatomical Context for Superficial Siderosis of the Central Nervous System

MalaCards organs/tissues related to Superficial Siderosis of the Central Nervous System:

⁴⁰

Brain, Pituitary, Bone, Spinal Cord, Testes, Heart, Tongue

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Publications for Superficial Siderosis of the Central Nervous System

Articles related to Superficial Siderosis of the Central Nervous System:

(show top 50) (show all 161)

#	Title	Authors	PMID	Year
1	[Superficial siderosis of the central nervous system : A consequence of spinal dural leaks persisting for decades]. ⁶¹	Friedauer L...Foerch C	30969349	2019
2	Multiple cavernous malformations as a cause for superficial siderosis of the central nervous system. ⁶¹	Richard C...Hebant B	31784939	2019
3	Detection of Spinal Dural Defect in Superficial Siderosis by Intraoperative Ultrasonography. ⁶¹	Machino M...Ishiguro N	31252076	2019
4	[Superficial siderosis of the central nervous system caused by myxopapillary ependymoma of conus medullaris and cauda equine: a case report and literature review]. ⁶¹	Xu L...Liu XL	31420638	2019
5	Superficial Siderosis of the Central Nervous System: Neurotological Findings Related to Magnetic Resonance Imaging. ⁶¹	Wagner F...Vibert D	30516591	2019
6	Superficial Siderosis of Central Nervous System as Primary Clinical Manifestation Secondary to Intradural Thoracic Disk Herniation. ⁶¹	Wipplinger C...Hartl R	30048787	2018
7	Superficial Siderosis of the Central Nervous System Due to Recurrent Surgeries of the Thoracic Spine: A Rare Case. ⁶¹	Camlar M...Ozer F	30165218	2018
8	Updating superficial siderosis of the central nervous system: bleeding of a dorsal osteophyte into the subarachnoid space from a perforating artery. ⁶¹	Brembilla C...Bernucci C	30485230	2018
9	Isolated spinal cord compression syndrome revealing delayed extensive superficial siderosis of the central nervous system secondary to cervical root avulsion. ⁶¹	Nasri A...Gouider R	28580859	2018
10	Vestibular Dysfunction in Patients With Superficial Siderosis of the Central Nervous System. ⁶¹	Takeda T...Tsutsumi T	29889788	2018
11	Clival meningocele causing bilateral hearing loss in a child due to superficial siderosis of the central nervous system: case report. ⁶¹	Johans SJ...Germanwala AV	29451456	2018
12	Idiopathic infratentorial superficial siderosis of the central nervous system: case report and review of literature. ⁶¹	Stabile A...DiFrancesco JC	29122310	2018
13	Focused Neuro-Otological Review of Superficial Siderosis of the Central Nervous System. ⁶¹	Yoo A...Kattah JC	29892257	2018
14	Neuroimaging Applications in Chronic Ataxias. ⁶¹	Mascalchi M...Vella A	30473193	2018
15	Superficial siderosis of the central nervous system associated with intraspinal hemorrhage from ventral thoracic epidural veins and a ventral spinal CSF leak: case report. ⁶¹	Takai K...Taniguchi M	28338451	2017
16	Superficial siderosis of the central nervous system is a rare and possibly underdiagnosed disorder. ⁶¹	Fragoso YD...Wille PR	28226077	2017
17	Vestibular end organ injury induced by middle ear treatment with ferric chloride in rats. ⁶¹	Lee JH...Park BR	27022167	2017
18	Subjective hearing impairment after subarachnoid haemorrhage: Prevalence and risk factors. ⁶¹	Vos EM...Vergouwen MDI	28017208	2017
19	Superficial siderosis complicated by hydrocephalus: bleeding from the dura mater in the cerebrospinal fluid cavity after brain tumor surgery. ⁶¹	Takai K...Taniguchi M	27117905	2016
20	An autopsy case of superficial siderosis of the central nervous system accompanied by anterior sacral polycystic meningocele in neurofibromatosis type 1. ⁶¹	Matsumoto A...Hisanaga K	27356733	2016
21	Superficial Siderosis of the Central Nervous System Originating from the Thoracic Spine: A Case Report. ⁶¹	Ryu SM...Eoh W	27437021	2016
22	IV and V cranial nerves dysfunction as initial manifestations of superficial siderosis of the central nervous system. ⁶¹	Nascimento-Alves P...Fonseca AC	26988173	2016
23	Superficial siderosis of the central nervous system as a presentation of stage iv melanoma. ⁶¹	Nogales Romo MT...Porta-Etessam J	24856369	2016
24	Neurosensory deafness: Superficial siderosis of the central nervous system. ⁶¹	Tunon Gomez M...Piazza Dobarganes A	24726023	2015
25	Superficial siderosis of the central nervous system associated with incomplete dural closure following posterior fossa surgery: report of 3 cases. ⁶¹	Kumar R...Wetjen NM	26067619	2015
26	Superficial siderosis of the central nervous system with seizures onset. ⁶¹	Chen CY...Liu JL	26512155	2015
27	Superficial siderosis of the central nervous system. ⁶¹	Sampaio L...Pinto M	26240112	2015
28	Superficial siderosis of the central nervous system: A case report. ⁶¹	Gao JG...Liu JY	25780438	2015
29	Superficial siderosis of the central nervous system caused by hemorrhagic intraventricular craniopharyngioma: case report and literature review. ⁶¹	Tosaka M...Yoshimoto Y	24670310	2015
30	Superficial siderosis of the central nervous system induced by a single-episode of traumatic subarachnoid hemorrhage: a study using MRI-enhanced gradient echo T2 star-weighted angiography. ⁶¹	Zhao H...Gong X	25647424	2015
31	High noon back pain- severe pseudoradicular pain as a lead symptom of superficial siderosis: a case report. ⁶¹	Saft C...Forsting M	25371709	2014
32	Superficial siderosis of the central nervous system secondary to spinal ependymoma. ⁶¹	Pikis S...Itshayek E	25043164	2014
33	[Diffuse superficial siderosis of the central nervous system: four case reports and review of the literature]. ⁶¹	Calvo M...Aladro Y	25297478	2014
34	Superficial siderosis of the central nervous system presenting with dysuria initially. ⁶¹	Wei KK...Chi ZF	24698546	2014
35	Agranulocytosis with deferiprone treatment of superficial siderosis. ⁶¹	Huprikar N...Bunge P	23925681	2013
36	Superficial siderosis of the central nervous system due to chronic hemorrhage from a giant invasive prolactinoma. ⁶¹	Steinberg J...Itshayek E	23664407	2013
37	Auditory profile in superficial siderosis of the central nervous system: a prospective study. ⁶¹	Sydlowski SA...Ackley RS	23670174	2013
38	Superficial siderosis of the central nervous system: an usual cause of sensorineural hearing loss. ⁶¹	Ribeiro DC...Ribeiro C	23670335	2013
39	Superficial siderosis of the central nervous system: a post-mortem 7.0-tesla magnetic resonance imaging study with neuropathological correlates. ⁶¹	De Reuck J...Leys D	24281052	2013
40	Superficial siderosis: A rare occurrence in children. ⁶¹	Jadhav TM...Hegde AU	23560013	2012
41	[Superficial siderosis of the central nervous system treated with prednisolone]. ⁶¹	Behrndtz A...Simonsen CZ	22992482	2012
42	Genotypic and phenotypic correlation in an Italian population of hereditary amyloidosis TTR-related (HA-TTR): clinical and neurophysiological aids to diagnosis and some reflections on misdiagnosis. ⁶¹	Salvi F...Rapezzi C	22620967	2012
43	Programming peculiarities in two cochlear implant users with superficial siderosis of the central nervous system. ⁶¹	Bittencourt AG...Tsuji RK	22278194	2012
44	Superficial siderosis of the central nervous system: a rare cause of dementia with therapeutic consequences. ⁶¹	Dubessy AL...Belin C	22291165	2012
45	Successful outcome of cochlear implantation in a patient with superficial siderosis. ⁶¹	Nogueira C...Meehan T	22545393	2012
46	Cochlear implantation in superficial siderosis: a viable option? ⁶¹	Grover N...Ramsden JD	22251814	2011
47	[Superficial siderosis, an underestimated entity]. ⁶¹	Arion S...Cotton F	21726902	2011
48	Three cases of superficial siderosis of the central nervous system and review of the literature. ⁶¹	Posti JP...Roine S	21822983	2011
49	Superficial siderosis of the central nervous system: phenotype and implications for audiology and otology. ⁶¹	Sydlowski SA...Shallop J	21730883	2011
50	Temporal bone histopathology in a case of sensorineural hearing loss caused by superficial siderosis of the central nervous system and treated by cochlear implantation. ⁶¹	Nadol JB...O'Malley JT	21758021	2011

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Genes for Superficial Siderosis of the Central Nervous System

Genes related to Superficial Siderosis of the Central Nervous System (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FTH1	Ferritin Heavy Chain 1	Protein Coding	7.48	GeneCards inferred via : Publications (show sections)
2	LTF	Lactotransferrin	Protein Coding	7.48	GeneCards inferred via : Publications (show sections)
3	TF	Transferrin	Protein Coding	7.48	GeneCards inferred via : Publications (show sections)

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Variations for Superficial Siderosis of the Central Nervous System

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Expression for Superficial Siderosis of the Central Nervous System

Search GEO for disease gene expression data for Superficial Siderosis of the Central Nervous System.

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Pathways for Superficial Siderosis of the Central Nervous System

Pathways related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Insulin receptor recycling ⁶⁵ Show member pathways Collecting duct acid secretion ³⁶ Epithelial cell signaling in Helicobacter pylori infection ³⁶ Iron uptake and transport ⁶⁵ ROS, RNS production in phagocytes ⁶⁵ Transferrin endocytosis and recycling ⁶⁵ Vibrio cholerae infection ³⁶	11.71	TF FTH1
2	Mineral absorption ³⁶	10.92	TF FTH1
3	Ferroptosis ³⁶	10.56	TF FTH1
4	Iron metabolism in placenta ¹	9.7	TF FTH1

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GO Terms for Superficial Siderosis of the Central Nervous System

Cellular components related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.43	TF LTF FTH1
2	extracellular exosome	GO:0070062	9.33	TF LTF FTH1
3	cell	GO:0005623	9.13	TF LTF FTH1
4	tertiary granule lumen	GO:1904724	8.62	LTF FTH1

Biological processes related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neutrophil degranulation	GO:0043312	9.37	LTF FTH1
2	cellular protein metabolic process	GO:0044267	9.32	TF LTF
3	cellular iron ion homeostasis	GO:0006879	9.26	TF FTH1
4	retina homeostasis	GO:0001895	9.16	TF LTF
5	iron ion homeostasis	GO:0055072	8.96	TF LTF
6	iron ion transport	GO:0006826	8.62	TF FTH1

Molecular functions related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	iron ion binding	GO:0005506	9.16	LTF FTH1
2	ferrous iron binding	GO:0008198	8.96	TF FTH1
3	ferric iron binding	GO:0008199	8.62	TF FTH1

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Sources for Superficial Siderosis of the Central Nervous System

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

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⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

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⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

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⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

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⁷¹ UMLS

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⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia