MCID: SPR032
MIFTS: 23

Superficial Siderosis of the Central Nervous System

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Superficial Siderosis of the Central Nervous System

MalaCards integrated aliases for Superficial Siderosis of the Central Nervous System:

Name: Superficial Siderosis of the Central Nervous System 52

Classifications:



Summaries for Superficial Siderosis of the Central Nervous System

NIH Rare Diseases : 52 Superficial siderosis of the central nervous system is a rare condition that primarily affects the brain. Signs and symptoms generally develop in adulthood and may include hearing loss and cerebellar ataxia . Some affected people may also experience seizures , memory impairment, bladder disturbance, headaches, back pain, and/or dysarthria . Superficial siderosis of the central nervous system is thought to be caused by bleeding into a portion of the brain called the subarachnoid space (the area between the brain and the thin tissues that cover the brain). This bleeding can have a variety of causes, such as trauma, a tumor of the central nervous system, arteriovenous malformations , or an unknown cause. Not all people who experience bleeding into the subarachnoid space go on to develop superficial siderosis of the central nervous system. Treatment varies based on the underlying cause and severity of the condition and may include surgery and/or medications.

MalaCards based summary : Superficial Siderosis of the Central Nervous System is related to superficial siderosis and siderosis. An important gene associated with Superficial Siderosis of the Central Nervous System is FTH1 (Ferritin Heavy Chain 1), and among its related pathways/superpathways are Insulin receptor recycling and Mineral absorption. Affiliated tissues include brain, pituitary and bone.

Related Diseases for Superficial Siderosis of the Central Nervous System

Diseases related to Superficial Siderosis of the Central Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 superficial siderosis 32.0 TF LTF FTH1
2 siderosis 30.5 TF LTF FTH1
3 aceruloplasminemia 29.9 LTF FTH1
4 hemochromatosis, type 1 29.9 TF FTH1
5 ataxia and polyneuropathy, adult-onset 11.0
6 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.9
7 branchiootic syndrome 1 10.8
8 sensorineural hearing loss 10.8
9 benign ependymoma 10.6
10 cellular ependymoma 10.6
11 pathologic nystagmus 10.5
12 spastic paraparesis 10.4
13 cerebral amyloid angiopathy, cst3-related 10.4
14 neurofibromatosis, type iv, of riccardi 10.3
15 meningocele 10.3
16 hydrocephalus 10.3
17 arteriovenous malformation 10.3
18 visual epilepsy 10.3
19 hemosiderosis 10.3
20 neurogenic bladder 10.3
21 myxopapillary ependymoma 10.3
22 head injury 10.3
23 headache 10.3
24 seizure disorder 10.3
25 amyotrophic lateral sclerosis 1 10.1
26 medulloblastoma 10.1
27 neurofibromatosis, type i 10.1
28 scleroderma, familial progressive 10.1
29 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
30 cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1 10.1
31 pituitary adenoma, prolactin-secreting 10.1
32 aphasia 10.1
33 thrombosis 10.1
34 meningoencephalitis 10.1
35 intracranial aneurysm 10.1
36 pituitary apoplexy 10.1
37 pyelonephritis 10.1
38 dementia 10.1
39 toxic shock syndrome 10.1
40 normal pressure hydrocephalus 10.1
41 impotence 10.1
42 optic nerve disease 10.1
43 melanoma 10.1
44 exostosis 10.1
45 lateral sclerosis 10.1
46 astrocytoma 10.1
47 neurilemmoma 10.1
48 craniopharyngioma 10.1
49 papillary craniopharyngioma 10.1
50 meningeal melanocytoma 10.1

Graphical network of the top 20 diseases related to Superficial Siderosis of the Central Nervous System:



Diseases related to Superficial Siderosis of the Central Nervous System

Symptoms & Phenotypes for Superficial Siderosis of the Central Nervous System

Drugs & Therapeutics for Superficial Siderosis of the Central Nervous System

Search Clinical Trials , NIH Clinical Center for Superficial Siderosis of the Central Nervous System

Genetic Tests for Superficial Siderosis of the Central Nervous System

Anatomical Context for Superficial Siderosis of the Central Nervous System

MalaCards organs/tissues related to Superficial Siderosis of the Central Nervous System:

40
Brain, Pituitary, Bone, Spinal Cord, Testes, Heart, Tongue

Publications for Superficial Siderosis of the Central Nervous System

Articles related to Superficial Siderosis of the Central Nervous System:

(show top 50) (show all 161)
# Title Authors PMID Year
1
[Superficial siderosis of the central nervous system : A consequence of spinal dural leaks persisting for decades]. 61
30969349 2019
2
Multiple cavernous malformations as a cause for superficial siderosis of the central nervous system. 61
31784939 2019
3
Detection of Spinal Dural Defect in Superficial Siderosis by Intraoperative Ultrasonography. 61
31252076 2019
4
[Superficial siderosis of the central nervous system caused by myxopapillary ependymoma of conus medullaris and cauda equine: a case report and literature review]. 61
31420638 2019
5
Superficial Siderosis of the Central Nervous System: Neurotological Findings Related to Magnetic Resonance Imaging. 61
30516591 2019
6
Superficial Siderosis of Central Nervous System as Primary Clinical Manifestation Secondary to Intradural Thoracic Disk Herniation. 61
30048787 2018
7
Superficial Siderosis of the Central Nervous System Due to Recurrent Surgeries of the Thoracic Spine: A Rare Case. 61
30165218 2018
8
Updating superficial siderosis of the central nervous system: bleeding of a dorsal osteophyte into the subarachnoid space from a perforating artery. 61
30485230 2018
9
Isolated spinal cord compression syndrome revealing delayed extensive superficial siderosis of the central nervous system secondary to cervical root avulsion. 61
28580859 2018
10
Vestibular Dysfunction in Patients With Superficial Siderosis of the Central Nervous System. 61
29889788 2018
11
Clival meningocele causing bilateral hearing loss in a child due to superficial siderosis of the central nervous system: case report. 61
29451456 2018
12
Idiopathic infratentorial superficial siderosis of the central nervous system: case report and review of literature. 61
29122310 2018
13
Focused Neuro-Otological Review of Superficial Siderosis of the Central Nervous System. 61
29892257 2018
14
Neuroimaging Applications in Chronic Ataxias. 61
30473193 2018
15
Superficial siderosis of the central nervous system associated with intraspinal hemorrhage from ventral thoracic epidural veins and a ventral spinal CSF leak: case report. 61
28338451 2017
16
Superficial siderosis of the central nervous system is a rare and possibly underdiagnosed disorder. 61
28226077 2017
17
Vestibular end organ injury induced by middle ear treatment with ferric chloride in rats. 61
27022167 2017
18
Subjective hearing impairment after subarachnoid haemorrhage: Prevalence and risk factors. 61
28017208 2017
19
Superficial siderosis complicated by hydrocephalus: bleeding from the dura mater in the cerebrospinal fluid cavity after brain tumor surgery. 61
27117905 2016
20
An autopsy case of superficial siderosis of the central nervous system accompanied by anterior sacral polycystic meningocele in neurofibromatosis type 1. 61
27356733 2016
21
Superficial Siderosis of the Central Nervous System Originating from the Thoracic Spine: A Case Report. 61
27437021 2016
22
IV and V cranial nerves dysfunction as initial manifestations of superficial siderosis of the central nervous system. 61
26988173 2016
23
Superficial siderosis of the central nervous system as a presentation of stage iv melanoma. 61
24856369 2016
24
Neurosensory deafness: Superficial siderosis of the central nervous system. 61
24726023 2015
25
Superficial siderosis of the central nervous system associated with incomplete dural closure following posterior fossa surgery: report of 3 cases. 61
26067619 2015
26
Superficial siderosis of the central nervous system with seizures onset. 61
26512155 2015
27
Superficial siderosis of the central nervous system. 61
26240112 2015
28
Superficial siderosis of the central nervous system: A case report. 61
25780438 2015
29
Superficial siderosis of the central nervous system caused by hemorrhagic intraventricular craniopharyngioma: case report and literature review. 61
24670310 2015
30
Superficial siderosis of the central nervous system induced by a single-episode of traumatic subarachnoid hemorrhage: a study using MRI-enhanced gradient echo T2 star-weighted angiography. 61
25647424 2015
31
High noon back pain- severe pseudoradicular pain as a lead symptom of superficial siderosis: a case report. 61
25371709 2014
32
Superficial siderosis of the central nervous system secondary to spinal ependymoma. 61
25043164 2014
33
[Diffuse superficial siderosis of the central nervous system: four case reports and review of the literature]. 61
25297478 2014
34
Superficial siderosis of the central nervous system presenting with dysuria initially. 61
24698546 2014
35
Agranulocytosis with deferiprone treatment of superficial siderosis. 61
23925681 2013
36
Superficial siderosis of the central nervous system due to chronic hemorrhage from a giant invasive prolactinoma. 61
23664407 2013
37
Auditory profile in superficial siderosis of the central nervous system: a prospective study. 61
23670174 2013
38
Superficial siderosis of the central nervous system: an usual cause of sensorineural hearing loss. 61
23670335 2013
39
Superficial siderosis of the central nervous system: a post-mortem 7.0-tesla magnetic resonance imaging study with neuropathological correlates. 61
24281052 2013
40
Superficial siderosis: A rare occurrence in children. 61
23560013 2012
41
[Superficial siderosis of the central nervous system treated with prednisolone]. 61
22992482 2012
42
Genotypic and phenotypic correlation in an Italian population of hereditary amyloidosis TTR-related (HA-TTR): clinical and neurophysiological aids to diagnosis and some reflections on misdiagnosis. 61
22620967 2012
43
Programming peculiarities in two cochlear implant users with superficial siderosis of the central nervous system. 61
22278194 2012
44
Superficial siderosis of the central nervous system: a rare cause of dementia with therapeutic consequences. 61
22291165 2012
45
Successful outcome of cochlear implantation in a patient with superficial siderosis. 61
22545393 2012
46
Cochlear implantation in superficial siderosis: a viable option? 61
22251814 2011
47
[Superficial siderosis, an underestimated entity]. 61
21726902 2011
48
Three cases of superficial siderosis of the central nervous system and review of the literature. 61
21822983 2011
49
Superficial siderosis of the central nervous system: phenotype and implications for audiology and otology. 61
21730883 2011
50
Temporal bone histopathology in a case of sensorineural hearing loss caused by superficial siderosis of the central nervous system and treated by cochlear implantation. 61
21758021 2011

Variations for Superficial Siderosis of the Central Nervous System

Expression for Superficial Siderosis of the Central Nervous System

Search GEO for disease gene expression data for Superficial Siderosis of the Central Nervous System.

Pathways for Superficial Siderosis of the Central Nervous System

Pathways related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.71 TF FTH1
2 10.92 TF FTH1
3 10.56 TF FTH1
4 9.7 TF FTH1

GO Terms for Superficial Siderosis of the Central Nervous System

Cellular components related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 TF LTF FTH1
2 extracellular exosome GO:0070062 9.33 TF LTF FTH1
3 cell GO:0005623 9.13 TF LTF FTH1
4 tertiary granule lumen GO:1904724 8.62 LTF FTH1

Biological processes related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.37 LTF FTH1
2 cellular protein metabolic process GO:0044267 9.32 TF LTF
3 cellular iron ion homeostasis GO:0006879 9.26 TF FTH1
4 retina homeostasis GO:0001895 9.16 TF LTF
5 iron ion homeostasis GO:0055072 8.96 TF LTF
6 iron ion transport GO:0006826 8.62 TF FTH1

Molecular functions related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.16 LTF FTH1
2 ferrous iron binding GO:0008198 8.96 TF FTH1
3 ferric iron binding GO:0008199 8.62 TF FTH1

Sources for Superficial Siderosis of the Central Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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