MCID: SPR032
MIFTS: 25

Superficial Siderosis of the Central Nervous System

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Superficial Siderosis of the Central Nervous System

MalaCards integrated aliases for Superficial Siderosis of the Central Nervous System:

Name: Superficial Siderosis of the Central Nervous System 53

Classifications:



Summaries for Superficial Siderosis of the Central Nervous System

NIH Rare Diseases : 53 Superficial siderosis of the central nervous system is a rare condition that primarily affects the brain. Signs and symptoms generally develop in adulthood and may include hearing loss and cerebellar ataxia. Some affected people may also experience seizures, memory impairment, bladder disturbance, headaches, back pain, and/or dysarthria. Superficial siderosis of the central nervous system is thought to be caused by bleeding into a portion of the brain called the subarachnoid space (the area between the brain and the thin tissues that cover the brain). This bleeding can have a variety of causes, such as trauma, a tumor of the central nervous system, arteriovenous malformations, or an unknown cause. Not all people who experience bleeding into the subarachnoid space go on to develop superficial siderosis of the central nervous system. Treatment varies based on the underlying cause and severity of the condition and may include surgery and/or medications.

MalaCards based summary : Superficial Siderosis of the Central Nervous System is related to superficial siderosis and siderosis. An important gene associated with Superficial Siderosis of the Central Nervous System is FTH1 (Ferritin Heavy Chain 1), and among its related pathways/superpathways are Insulin receptor recycling and Mineral absorption. Affiliated tissues include brain, bone and spinal cord.

Related Diseases for Superficial Siderosis of the Central Nervous System

Diseases related to Superficial Siderosis of the Central Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 superficial siderosis 32.5 FTH1 LTF TF
2 siderosis 31.4 FTH1 TF
3 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
4 sensorineural hearing loss 10.5
5 neurofibromatosis, type i 10.3
6 meningocele 10.3
7 amyotrophic lateral sclerosis 1 10.1
8 multiple sclerosis 10.1
9 scleroderma, familial progressive 10.1
10 thrombosis 10.1
11 intracranial aneurysm 10.1
12 dementia 10.1
13 melanoma 10.1
14 exostosis 10.1
15 lateral sclerosis 10.1
16 craniopharyngioma 10.1
17 meningeal melanocytoma 10.1
18 ependymoma 10.1
19 depression 10.1
20 headache 10.1
21 haemophilus influenzae 9.8 LTF TF
22 cardiomyopathy, familial hypertrophic, 9 9.8 FTH1 TF
23 radiation proctitis 9.8 LTF TF
24 dysentery 9.8 LTF TF
25 hemochromatosis, type 1 9.6 FTH1 TF

Graphical network of the top 20 diseases related to Superficial Siderosis of the Central Nervous System:



Diseases related to Superficial Siderosis of the Central Nervous System

Symptoms & Phenotypes for Superficial Siderosis of the Central Nervous System

Drugs & Therapeutics for Superficial Siderosis of the Central Nervous System

Search Clinical Trials , NIH Clinical Center for Superficial Siderosis of the Central Nervous System

Genetic Tests for Superficial Siderosis of the Central Nervous System

Anatomical Context for Superficial Siderosis of the Central Nervous System

MalaCards organs/tissues related to Superficial Siderosis of the Central Nervous System:

41
Brain, Bone, Spinal Cord

Publications for Superficial Siderosis of the Central Nervous System

Articles related to Superficial Siderosis of the Central Nervous System:

(show top 50) (show all 101)
# Title Authors Year
1
Clival meningocele causing bilateral hearing loss in a child due to superficial siderosis of the central nervous system: case report. ( 29451456 )
2018
2
Vestibular Dysfunction in Patients With Superficial Siderosis of the Central Nervous System. ( 29889788 )
2018
3
Focused Neuro-Otological Review of Superficial Siderosis of the Central Nervous System. ( 29892257 )
2018
4
Idiopathic infratentorial superficial siderosis of the central nervous system: case report and review of literature. ( 29122310 )
2018
5
Superficial Siderosis of the Central Nervous System Due to Recurrent Surgeries of the Thoracic Spine: A Rare Case. ( 30165218 )
2018
6
Updating superficial siderosis of the central nervous system: bleeding of a dorsal osteophyte into the subarachnoid space from a perforating artery. ( 30485230 )
2018
7
Superficial Siderosis of the Central Nervous System: Neurotological Findings Related to Magnetic Resonance Imaging. ( 30516591 )
2018
8
Isolated spinal cord compression syndrome revealing delayed extensive superficial siderosis of the central nervous system secondary to cervical root avulsion. ( 28580859 )
2017
9
Superficial siderosis of the central nervous system is a rare and possibly underdiagnosed disorder. ( 28226077 )
2017
10
Superficial siderosis of the central nervous system associated with intraspinal hemorrhage from ventral thoracic epidural veins and a ventral spinal CSF leak: case report. ( 28338451 )
2017
11
An autopsy case of superficial siderosis of the central nervous system accompanied by anterior sacral polycystic meningocele in neurofibromatosis type 1. ( 27356733 )
2016
12
IV and V cranial nerves dysfunction as initial manifestations of superficial siderosis of the central nervous system. ( 26988173 )
2016
13
Superficial Siderosis of the Central Nervous System Originating from the Thoracic Spine: A Case Report. ( 27437021 )
2016
14
Superficial siderosis of the central nervous system: A case report. ( 25780438 )
2015
15
Superficial siderosis of the central nervous system associated with incomplete dural closure following posterior fossa surgery: report of 3 cases. ( 26067619 )
2015
16
Superficial siderosis of the central nervous system with seizures onset. ( 26512155 )
2015
17
Superficial siderosis of the central nervous system induced by a single-episode of traumatic subarachnoid hemorrhage: a study using MRI-enhanced gradient echo T2 star-weighted angiography. ( 25647424 )
2015
18
Superficial siderosis of the central nervous system. ( 26240112 )
2015
19
Superficial siderosis of the central nervous system presenting with dysuria initially. ( 24698546 )
2014
20
Superficial Siderosis of the Central Nervous System Caused by Hemorrhagic Intraventricular Craniopharyngioma: Case Report and Literature Review. ( 24670310 )
2014
21
Superficial siderosis of the central nervous system as a presentation of stage iv melanoma. ( 24856369 )
2014
22
Neurosensory deafness: Superficial siderosis of the central nervous system. ( 24726023 )
2014
23
Superficial siderosis of the central nervous system secondary to spinal ependymoma. ( 25043164 )
2014
24
Superficial siderosis of the central nervous system: a post-mortem 7.0-tesla magnetic resonance imaging study with neuropathological correlates. ( 24281052 )
2013
25
Auditory profile in superficial siderosis of the central nervous system: a prospective study. ( 23670174 )
2013
26
Superficial siderosis of the central nervous system due to chronic hemorrhage from a giant invasive prolactinoma. ( 23664407 )
2013
27
Superficial siderosis of the central nervous system: an usual cause of sensorineural hearing loss. ( 23670335 )
2013
28
Programming peculiarities in two cochlear implant users with superficial siderosis of the central nervous system. ( 22278194 )
2012
29
Superficial siderosis of the central nervous system: a rare cause of dementia with therapeutic consequences. ( 22291165 )
2012
30
Three cases of superficial siderosis of the central nervous system and review of the literature. ( 21822983 )
2011
31
Superficial siderosis of the central nervous system. ( 24059615 )
2011
32
Superficial siderosis of the central nervous system: phenotype and implications for audiology and otology. ( 21730883 )
2011
33
Temporal bone histopathology in a case of sensorineural hearing loss caused by superficial siderosis of the central nervous system and treated by cochlear implantation. ( 21758021 )
2011
34
Superficial siderosis of the central nervous system: MR findings with susceptibility-weighted imaging. ( 21513860 )
2011
35
Superficial siderosis of the central nervous system presenting with hallucination and delusion: a case report. ( 21682814 )
2011
36
Superficial siderosis of the central nervous system manifested with seizures. ( 20006512 )
2010
37
Superficial siderosis of the central nervous system: an unusual cause of sensorineural hearing loss. ( 20602058 )
2010
38
Superficial siderosis of the central nervous system: secondary progression despite successful surgical treatment, mimicking amyotrophic lateral sclerosis. Case report and review. ( 20414791 )
2010
39
CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: two case reports. ( 19747766 )
2010
40
Superficial siderosis of the central nervous system after ventriculoperitoneal shunt. ( 20001593 )
2010
41
Superficial siderosis of the central nervous system due to bilateral jugular vein thrombosis. ( 20937957 )
2010
42
Successful cochlear implantation in a patient with superficial siderosis of the central nervous system. ( 19887990 )
2010
43
Superficial siderosis of the central nervous system - treatment with steroids? ( 19753681 )
2009
44
Iron localization in superficial siderosis of the central nervous system. ( 18694445 )
2009
45
Intralabyrinthine hemorrhage associated with superficial siderosis of the central nervous system. ( 18401286 )
2009
46
Cognitive impairment in superficial siderosis of the central nervous system: a case report. ( 18937022 )
2009
47
Superficial siderosis of the central nervous system and its cochleovestibular consequences. ( 19137643 )
2008
48
The pathology of superficial siderosis of the central nervous system. ( 18696091 )
2008
49
Systemic sclerosis and superficial siderosis of the central nervous system: casuality or causality? ( 18193230 )
2008
50
Unsuccessful cochlear implantation in two patients with superficial siderosis of the central nervous system. ( 18665029 )
2008

Variations for Superficial Siderosis of the Central Nervous System

Expression for Superficial Siderosis of the Central Nervous System

Search GEO for disease gene expression data for Superficial Siderosis of the Central Nervous System.

Pathways for Superficial Siderosis of the Central Nervous System

Pathways related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.7 FTH1 TF
2 10.86 FTH1 TF
3 10.56 FTH1 TF
4 9.7 FTH1 TF

GO Terms for Superficial Siderosis of the Central Nervous System

Cellular components related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.33 FTH1 LTF TF
2 extracellular exosome GO:0070062 9.13 FTH1 LTF TF
3 tertiary granule lumen GO:1904724 8.62 FTH1 LTF

Biological processes related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.37 FTH1 LTF
2 cellular protein metabolic process GO:0044267 9.32 LTF TF
3 cellular iron ion homeostasis GO:0006879 9.26 FTH1 TF
4 retina homeostasis GO:0001895 9.16 LTF TF
5 iron ion homeostasis GO:0055072 8.96 LTF TF
6 iron ion transport GO:0006826 8.62 FTH1 TF

Molecular functions related to Superficial Siderosis of the Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.16 FTH1 LTF
2 ferrous iron binding GO:0008198 8.96 FTH1 TF
3 ferric iron binding GO:0008199 8.62 FTH1 TF

Sources for Superficial Siderosis of the Central Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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