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SLK
MCID: SPR034
MIFTS: 30

Superior Limbic Keratoconjunctivitis (SLK)

Categories: Eye diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Superior Limbic Keratoconjunctivitis

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MalaCards integrated aliases for Superior Limbic Keratoconjunctivitis:

Name: Superior Limbic Keratoconjunctivitis 52 58 71
Theodore Superior Limbic Keratoconjunctivitis 52 58
Theodore Syndrome 52 58
Slk 52 58
Theodores Superior Limbic Keratoconjunctivitis 52
Theodores Syndrome 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare eye diseases


External Ids:

ICD10 via Orphanet 33 H16.2
UMLS via Orphanet 72 C0339229
Orphanet 58 ORPHA88633
UMLS 71 C0339229
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Summaries for Superior Limbic Keratoconjunctivitis

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NIH Rare Diseases : 52 Superior limbic keratoconjunctivitis (SLK) is a chronic and recurrent eye disease which affects the superior bulbar conjunctiva (the clear layer that covers the eyeball, over the sclera ) and tarsal conjunctiva (the clear layer that lines the eyelids), as well as the superior limbic aspect of the cornea (the area above the cornea ). It is commonly found in women 20-70 years of age. The signs and symptoms include burning, redness and irritation and tend to develop slowly over a period of 1 to 10 years. Vision usually remains intact. While the underlying cause of SLK remains unknown, it is believed that the condition is secondary to superior bulbar conjunctiva laxity. Factors inducing conjunctiva laxity include thyroid eye disease (usually hyperthyroidism ), tight upper eyelids, and prominent globes. A mimicking disorder has been encountered in soft contact lens (SCL) wearers, typically with exposure to thimerosal-preserved solutions. Treatment of SLK may involve the use of various medications, surgery, or a combination of both.

MalaCards based summary : Superior Limbic Keratoconjunctivitis, also known as theodore superior limbic keratoconjunctivitis, is related to conjunctivochalasis and advanced sleep phase syndrome, familial, 1. An important gene associated with Superior Limbic Keratoconjunctivitis is MMP1 (Matrix Metallopeptidase 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and IL-17 Family Signaling Pathways. Affiliated tissues include eye and thyroid.

Wikipedia : 74 Superior limbic keratoconjunctivitis is an ocular disease characterized by episodes of recurrent... more...

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Related Diseases for Superior Limbic Keratoconjunctivitis

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Diseases related to Superior Limbic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 conjunctivochalasis 30.2 MMP3 MMP1
2 advanced sleep phase syndrome, familial, 1 11.2
3 advanced sleep phase syndrome, familial, 3 11.2
4 autoimmune glomerulonephritis 11.2
5 keratoconjunctivitis 11.0
6 acute kidney failure 10.4
7 anoxia 10.3
8 keratitis, hereditary 10.3
9 keratopathy 10.3
10 kaposi sarcoma 10.3
11 eye disease 10.2
12 bladder cancer 10.1
13 renal cell carcinoma, nonpapillary 10.1
14 membranous nephropathy 10.1
15 cerebral artery occlusion 10.1
16 portal hypertension 10.1
17 hepatorenal syndrome 10.1
18 myopathy 10.1
19 clear cell renal cell carcinoma 10.1
20 end stage renal disease 10.1
21 autoimmune disease 10.1
22 astigmatism 10.1
23 graft-versus-host disease 10.1
24 dry eye syndrome 10.1
25 allergic hypersensitivity disease 10.1
26 graves' disease 10.1
27 keratoconjunctivitis sicca 10.1
28 hyperparathyroidism 10.1
29 giant papillary conjunctivitis 10.1
30 papillary conjunctivitis 10.1
31 filamentary keratitis 10.1
32 sebaceous adenocarcinoma 10.1
33 conjunctivitis 10.1
34 eyelid carcinoma 10.1
35 hyperthyroidism 10.1
36 exophthalmos 10.1
37 chronic graft versus host disease 10.1
38 cytokine deficiency 10.1
39 limbal stem cell deficiency 10.1
40 tendinopathy 9.8 MMP3 MMP1
41 spastic entropion 9.8 MMP3 MMP1
42 tendinosis 9.8 MMP3 MMP1
43 epidermolysis bullosa dystrophica 9.8 MMP3 MMP1
44 corneal edema 9.8 MMP3 MMP1
45 gastroschisis 9.8 MMP3 MMP1
46 bone deterioration disease 9.8 MMP3 MMP1
47 viral meningitis 9.8 MMP3 MMP1
48 chondrocalcinosis 9.8 MMP3 MMP1
49 spinal stenosis 9.8 MMP3 MMP1
50 septic arthritis 9.8 MMP3 MMP1

Graphical network of the top 20 diseases related to Superior Limbic Keratoconjunctivitis:



Diseases related to Superior Limbic Keratoconjunctivitis
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Symptoms & Phenotypes for Superior Limbic Keratoconjunctivitis

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Drugs & Therapeutics for Superior Limbic Keratoconjunctivitis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Role of Cytokines and Mast Cell in the Pathogenesis of Ocular Surface Inflammation Diseases Including Superior Limbic Keratoconjunctivitis, Conjunctivochalasis, and Dry Eye Unknown status NCT02160327
2 The Pathogenesis of Superior Limbic Keratoconjunctivitis Unknown status NCT00167050
3 The Expression Levels of Diadenosine Polyphosphates and Mucin in Mechanical Stress-related Ocular Surface Disorders Recruiting NCT03731624

Search NIH Clinical Center for Superior Limbic Keratoconjunctivitis

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Genetic Tests for Superior Limbic Keratoconjunctivitis

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Anatomical Context for Superior Limbic Keratoconjunctivitis

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MalaCards organs/tissues related to Superior Limbic Keratoconjunctivitis:

40
Eye, Thyroid
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Publications for Superior Limbic Keratoconjunctivitis

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Articles related to Superior Limbic Keratoconjunctivitis:

(show top 50) (show all 99)
# Title Authors PMID Year
1
Tear cytokine profiling in patients with superior limbic keratoconjunctivitis who underwent medical treatment or in conjunction with surgical management. 61
30926588 2020
2
Eyelid metrics assessment in patients with chronic ocular graft versus-host disease. 61
30321606 2019
3
Influence of Meibomian Gland Dysfunction and Friction-Related Disease on the Severity of Dry Eye. 61
29459039 2018
4
Clinical Severity Classification using Automated Conjunctival Hyperemia Analysis Software in Patients with Superior Limbic Keratoconjunctivitis. 61
29336627 2018
5
Efficacy and safety of 0.1% lodoxamide for the long-term treatment of superior limbic keratoconjunctivitis. 61
28602013 2018
6
High Inflammatory Infiltrate Correlates With Poor Symptomatic Improvement After Surgical Treatment for Superior Limbic Keratoconjunctivitis. 61
29346129 2018
7
TFOS DEWS II pathophysiology report. 61
28736340 2017
8
Superior Limbic Keratoconjunctivitis-like Inflammation in Patients with Chronic Graft-Versus-Host Disease. 61
27179980 2016
9
Stem Cell Factor and Thymic Stromal Lymphopoietin Overexpression With Correlation to Mast Cells in Superior Limbic Keratoconjunctivitis. 61
26382891 2015
10
Autologous serum eye drops for the treatment of ocular surface disease. 61
25603439 2015
11
Extensive superior limbic keratoconjunctivitis in Graves' disease: case report and mini-review of the literature. 61
25792798 2015
12
Topical rebamipide treatment for superior limbic keratoconjunctivitis in patients with thyroid eye disease. 61
24412123 2014
13
Surgical approach with high-frequency radiowave electrosurgery for superior limbic keratoconjunctivitis. 61
24322803 2014
14
Treatment of superior limbic keratoconjunctivitis with topical tacrolimus 0.03% ointment. 61
23770977 2013
15
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. 61
23791418 2013
16
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. 61
23158547 2012
17
Combined application of autologous serum eye drops and silicone hydrogel lenses for the treatment of persistent epithelial defects. 61
21983552 2011
18
Overexpression of matrix metalloproteinase-1 (MMP-1) and MMP-3 in superior limbic keratoconjunctivitis. 61
21357403 2011
19
Ocular surface squamous neoplasia masquerading as superior limbic keratoconjunctivitis. 61
21572741 2011
20
Long-term use of hydroxypropyl cellulose ophthalmic insert to relieve symptoms of dry eye in a contact lens wearer: case-based experience. 61
21178699 2011
21
Conjunctival resection with and without amniotic membrane graft for the treatment of superior limbic keratoconjunctivitis. 61
20539210 2010
22
In vivo evaluation of superior limbic keratoconjunctivitis using laser scanning confocal microscopy and conjunctival impression cytology. 61
20375341 2010
23
Conjunctival fixation sutures for refractory superior limbic keratoconjunctivitis. 61
18812388 2009
24
Treatment of superior limbic keratoconjunctivitis with a large-diameter contact lens and Botulium Toxin A. 61
19574913 2009
25
[Use of fibrin glue in ocular surgery]. 61
19668958 2009
26
Liquid nitrogen cryotherapy of superior limbic keratoconjunctivitis. 61
18835475 2009
27
Autologous serum for ocular surface diseases. 61
19274411 2008
28
Autologous serum eye drops for the treatment of dry eye diseases. 61
18813071 2008
29
Conjunctival resection combined with tenon layer excision and the involvement of mast cells in superior limbic keratoconjunctivitis. 61
18201682 2008
30
Topical cyclosporine a in the treatment of superior limbic keratoconjunctivitis: a long-term follow-up. 61
18216575 2008
31
Surgery of the conjunctiva. 61
18453766 2008
32
Liquid nitrogen cryotherapy for surface eye disease (an AOS thesis). 61
19277243 2008
33
New surgical approach for superior conjunctivochalasis. 61
17592317 2007
34
Supratarsal triamcinolone injection in the treatment of superior limbic keratoconjunctivitis. 61
17457190 2007
35
Development of superior limbic keratoconjunctivitis after upper eyelid blepharoplasty surgery: support for the mechanical theory of its pathogenesis. 61
17457203 2007
36
Reconstruction of the ocular surface by transplantation of a serum-free derived cultivated conjunctival epithelial equivalent. 61
15201674 2004
37
Topical cyclosporine A 0.5% as a possible new treatment for superior limbic keratoconjunctivitis. 61
12917176 2003
38
Blink-related microtrauma: when the ocular surface harms itself. 61
12786767 2003
39
[Two cases of primary biliary cirrhosis accompanied with severe keratoconjunctivitis sicca due to Sjögren syndrome]. 61
12755067 2003
40
New surgical treatment for superior limbic keratoconjunctivitis and its association with conjunctivochalasis. 61
12614746 2003
41
Thyroid and the eye. 61
12441836 2002
42
Ketotifen fumarate treatment of superior limbic keratoconjunctivitis. 61
12410035 2002
43
Treatment of superior limbic keratoconjunctivitis with a unilateral bandage contact lens. 61
11914237 2002
44
The clinical efficacy of silicone punctal plug therapy. 61
11862081 2002
45
Evaluation of extraocular muscle enlargement in dysthyroid ophthalmopathy. 61
11754905 2001
46
Treatment of superior limbic keratoconjunctivitis by application of autologous serum. 61
11685056 2001
47
Expression of involucrin by ocular surface epithelia of patients with benign and malignant disorders. 61
11262609 2000
48
Superior limbic keratoconjunctivitis: multifactorial mechanical pathogenesis. 61
10981793 2000
49
[Evaluation of extraocular muscle enlargement in dysthyroid ophthalmopathy]. 61
10659624 2000
50
TGF-beta2, tenascin, and integrin beta1 expression in superior limbic keratoconjunctivitis. 61
10482468 1999
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Variations for Superior Limbic Keratoconjunctivitis

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Expression for Superior Limbic Keratoconjunctivitis

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Search GEO for disease gene expression data for Superior Limbic Keratoconjunctivitis.
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Pathways for Superior Limbic Keratoconjunctivitis

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Pathways related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 65
Show member pathways
 12.11 MMP3 MMP1
2
IL-17 Family Signaling Pathways 64
Show member pathways
 11.77 MMP3 MMP1
3
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 11.72 MMP3 MMP1
4
Interleukin-4 and 13 signaling 65
11.43 MMP3 MMP1
5
Matrix Metalloproteinases 1
Show member pathways
 11.32 MMP3 MMP1
6
Rheumatoid arthritis 36
11.23 MMP3 MMP1
7
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.96 MMP3 MMP1
8
Cell adhesion_ECM remodeling 22
10.74 MMP3 MMP1
9
Cell adhesion_Cell-matrix glycoconjugates 22
10.21 MMP3 MMP1
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GO Terms for Superior Limbic Keratoconjunctivitis

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Cellular components related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.62 MMP3 MMP1

Biological processes related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.37 MMP3 MMP1
2 cytokine-mediated signaling pathway GO:0019221 9.32 MMP3 MMP1
3 extracellular matrix organization GO:0030198 9.26 MMP3 MMP1
4 extracellular matrix disassembly GO:0022617 9.16 MMP3 MMP1
5 positive regulation of protein complex assembly GO:0031334 8.96 MMP3 MMP1
6 collagen catabolic process GO:0030574 8.62 MMP3 MMP1

Molecular functions related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.32 MMP3 MMP1
2 serine-type endopeptidase activity GO:0004252 9.26 MMP3 MMP1
3 metallopeptidase activity GO:0008237 9.16 MMP3 MMP1
4 metalloendopeptidase activity GO:0004222 8.96 MMP3 MMP1
5 endopeptidase activity GO:0004175 8.62 MMP3 MMP1
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Sources for Superior Limbic Keratoconjunctivitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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