MCID: SPR034
MIFTS: 33

Superior Limbic Keratoconjunctivitis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Superior Limbic Keratoconjunctivitis

MalaCards integrated aliases for Superior Limbic Keratoconjunctivitis:

Name: Superior Limbic Keratoconjunctivitis 53 59 73
Slk 53 59
Theodore's Superior Limbic Keratoconjunctivitis 59
Theodores Superior Limbic Keratoconjunctivitis 53
Theodore's Syndrome 59
Theodores Syndrome 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA88633
UMLS via Orphanet 74 C0339229
ICD10 via Orphanet 34 H16.2
UMLS 73 C0339229

Summaries for Superior Limbic Keratoconjunctivitis

NIH Rare Diseases : 53 Superior limbic keratoconjunctivitis (SLK) is a chronic and recurrent eye disease which affects the superior bulbar conjunctiva (the clear layer that covers the eyeball, over the sclera) and tarsal conjunctiva (the clear layer that lines the eyelids), as well as the superior limbic aspect of the cornea (the area above the cornea). It is commonly found in women 20-70 years of age. The signs and symptoms include burning, redness and irritation and tend to develop slowly over a period of 1 to 10 years. Vision usually remains intact. While the underlying cause of SLK remains unknown, it is believed that the condition is secondary to superior bulbar conjunctiva laxity.  Factors inducing conjunctiva laxity include  thyroid eye disease (usually hyperthyroidism), tight upper eyelids, and prominent globes. A mimicking disorder has been encountered in soft contact lens (SCL) wearers, typically with exposure to thimerosal-preserved solutions. Treatment of SLK may involve the use of various medications, surgery, or a combination of both.

MalaCards based summary : Superior Limbic Keratoconjunctivitis, also known as slk, is related to conjunctivochalasis and robinow syndrome, autosomal dominant 1. An important gene associated with Superior Limbic Keratoconjunctivitis is MMP1 (Matrix Metallopeptidase 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and IL-17 Family Signaling Pathways. Affiliated tissues include eye and thyroid.

Wikipedia : 76 Superior limbic keratoconjunctivitis is an ocular disease characterized by episodes of recurrent... more...

Related Diseases for Superior Limbic Keratoconjunctivitis

Diseases related to Superior Limbic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 conjunctivochalasis 29.6 MMP1 MMP3
2 robinow syndrome, autosomal dominant 1 11.1
3 amyotrophic lateral sclerosis 9 11.1
4 keratoconjunctivitis 10.8
5 conjunctivitis 9.9
6 thyroiditis 9.9
7 chronic graft versus host disease 9.9
8 graft-versus-host disease 9.9
9 graves' disease 9.9
10 giant papillary conjunctivitis 9.9
11 papillary conjunctivitis 9.9
12 breast cancer 9.9
13 sarcoma 9.9
14 spastic entropion 9.8 MMP1 MMP3
15 adult astrocytic tumour 9.8 MMP1 MMP3
16 adenomyosis 9.8 MMP1 MMP3
17 corneal edema 9.8 MMP1 MMP3
18 epidermolysis bullosa dystrophica 9.8 MMP1 MMP3
19 tendinosis 9.8 MMP1 MMP3
20 bone deterioration disease 9.8 MMP1 MMP3
21 pelvic organ prolapse 9.8 MMP1 MMP3
22 coronary artery aneurysm 9.7 MMP1 MMP3
23 lymph node disease 9.7 MMP1 MMP3
24 gingival overgrowth 9.7 MMP1 MMP3
25 varicose veins 9.7 MMP1 MMP3
26 bone inflammation disease 9.7 MMP1 MMP3
27 gingival fibromatosis 9.7 MMP1 MMP3
28 aortic aneurysm, familial abdominal, 1 9.7 MMP1 MMP3
29 synovitis 9.7 MMP1 MMP3
30 periodontitis 9.6 MMP1 MMP3
31 periodontal disease 9.6 MMP1 MMP3
32 chondrosarcoma 9.6 MMP1 MMP3
33 psoriatic arthritis 9.6 MMP1 MMP3
34 fibrosarcoma 9.6 MMP1 MMP3
35 osteoarthritis 9.5 MMP1 MMP3
36 keratoconus 9.5 MMP1 MMP3
37 arthritis 9.4 MMP1 MMP3
38 ewing sarcoma 9.3 MMP1 MMP3
39 rheumatoid arthritis 9.2 MMP1 MMP3
40 inflammatory bowel disease 9.0 MMP1 MMP3

Graphical network of the top 20 diseases related to Superior Limbic Keratoconjunctivitis:



Diseases related to Superior Limbic Keratoconjunctivitis

Symptoms & Phenotypes for Superior Limbic Keratoconjunctivitis

Drugs & Therapeutics for Superior Limbic Keratoconjunctivitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Pathogenesis of Superior Limbic Keratoconjunctivitis Unknown status NCT00167050
2 The Role of Cytokines and Mast Cell in the Pathogenesis of SLK, Conjunctivochalasis, and Dry Eye Unknown status NCT02160327

Search NIH Clinical Center for Superior Limbic Keratoconjunctivitis

Genetic Tests for Superior Limbic Keratoconjunctivitis

Anatomical Context for Superior Limbic Keratoconjunctivitis

MalaCards organs/tissues related to Superior Limbic Keratoconjunctivitis:

41
Eye, Thyroid

Publications for Superior Limbic Keratoconjunctivitis

Articles related to Superior Limbic Keratoconjunctivitis:

(show top 50) (show all 65)
# Title Authors Year
1
High Inflammatory Infiltrate Correlates With Poor Symptomatic Improvement After Surgical Treatment for Superior Limbic Keratoconjunctivitis. ( 29346129 )
2018
2
Clinical Severity Classification using Automated Conjunctival Hyperemia Analysis Software in Patients with Superior Limbic Keratoconjunctivitis. ( 29336627 )
2018
3
Efficacy and safety of 0.1% lodoxamide for the long-term treatment of superior limbic keratoconjunctivitis. ( 28602013 )
2017
4
Superior Limbic Keratoconjunctivitis-like Inflammation in Patients with Chronic Graft-Versus-Host Disease. ( 27179980 )
2016
5
Extensive superior limbic keratoconjunctivitis in Graves' disease: case report and mini-review of the literature. ( 25792798 )
2015
6
Stem Cell Factor and Thymic Stromal Lymphopoietin Overexpression With Correlation to Mast Cells in Superior Limbic Keratoconjunctivitis. ( 26382891 )
2015
7
Surgical approach with high-frequency radiowave electrosurgery for superior limbic keratoconjunctivitis. ( 24322803 )
2014
8
Topical Rebamipide Treatment for Superior Limbic Keratoconjunctivitis in Patients with Thyroid Eye Disease. ( 24412123 )
2014
9
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. ( 23791418 )
2013
10
Treatment of superior limbic keratoconjunctivitis with topical tacrolimus 0.03% ointment. ( 23770977 )
2013
11
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. ( 23158547 )
2012
12
Overexpression of matrix metalloproteinase-1 (MMP-1) and MMP-3 in superior limbic keratoconjunctivitis. ( 21357403 )
2011
13
Ocular surface squamous neoplasia masquerading as superior limbic keratoconjunctivitis. ( 21572741 )
2011
14
Conjunctival resection with and without amniotic membrane graft for the treatment of superior limbic keratoconjunctivitis. ( 20539210 )
2010
15
In vivo evaluation of superior limbic keratoconjunctivitis using laser scanning confocal microscopy and conjunctival impression cytology. ( 20375341 )
2010
16
Liquid nitrogen cryotherapy of superior limbic keratoconjunctivitis. ( 18835475 )
2009
17
Treatment of superior limbic keratoconjunctivitis with a large-diameter contact lens and Botulium Toxin A. ( 19574913 )
2009
18
Conjunctival fixation sutures for refractory superior limbic keratoconjunctivitis. ( 18812388 )
2009
19
Topical cyclosporine a in the treatment of superior limbic keratoconjunctivitis: a long-term follow-up. ( 18216575 )
2008
20
Conjunctival resection combined with tenon layer excision and the involvement of mast cells in superior limbic keratoconjunctivitis. ( 18201682 )
2008
21
Development of superior limbic keratoconjunctivitis after upper eyelid blepharoplasty surgery: support for the mechanical theory of its pathogenesis. ( 17457203 )
2007
22
Supratarsal triamcinolone injection in the treatment of superior limbic keratoconjunctivitis. ( 17457190 )
2007
23
Topical cyclosporine A 0.5% as a possible new treatment for superior limbic keratoconjunctivitis. ( 12917176 )
2003
24
New surgical treatment for superior limbic keratoconjunctivitis and its association with conjunctivochalasis. ( 12614746 )
2003
25
Treatment of superior limbic keratoconjunctivitis with a unilateral bandage contact lens. ( 11914237 )
2002
26
Ketotifen fumarate treatment of superior limbic keratoconjunctivitis. ( 12410035 )
2002
27
Treatment of superior limbic keratoconjunctivitis by application of autologous serum. ( 11685056 )
2001
28
Superior limbic keratoconjunctivitis: multifactorial mechanical pathogenesis. ( 10981793 )
2000
29
TGF-beta2, tenascin, and integrin beta1 expression in superior limbic keratoconjunctivitis. ( 10482468 )
1999
30
Diagnosis of Theodore's superior limbic keratoconjunctivitis. ( 9850281 )
1998
31
Lacrimal occlusion therapy for the treatment of superior limbic keratoconjunctivitis. ( 9798210 )
1998
32
Lacrimal punctal occlusion for the treatment of superior limbic keratoconjunctivitis. ( 9222236 )
1997
33
Cytokeratin and proliferative cell nuclear antigen expression in superior limbic keratoconjunctivitis. ( 8921242 )
1996
34
Superior limbic keratoconjunctivitis in association with scarring of the superior tarsal conjunctiva. ( 8713936 )
1996
35
Lodoxamide tromethamine treatment for superior limbic keratoconjunctivitis. ( 7661218 )
1995
36
Superior limbic keratoconjunctivitis. A prognostic sign for severe Graves ophthalmopathy. ( 9097794 )
1995
37
Management of superior limbic keratoconjunctivitis with botulinum toxin. ( 7713245 )
1995
38
Superior limbic keratoconjunctivitis in identical twins. ( 1587136 )
1992
39
Superior limbic keratoconjunctivitis (SLK). ( 2695351 )
1989
40
Protein and elemental analysis of contact lenses of patients with superior limbic keratoconjunctivitis or giant papillary conjunctivitis. ( 2717140 )
1989
41
Superior limbic keratoconjunctivitis apparently related to particulate material from a ventilation system. ( 2716779 )
1989
42
Vitamin A eyedrops for superior limbic keratoconjunctivitis. ( 3285694 )
1988
43
Treatment of superior limbic keratoconjunctivitis with topical cromolyn sodium. ( 3113315 )
1987
44
Superior limbic keratoconjunctivitis. ( 3804639 )
1986
45
Treatment of superior limbic keratoconjunctivitis by thermocauterization of the superior bulbar conjunctiva. ( 3951822 )
1986
46
Sebaceous carcinoma of the eyelid masquerading as superior limbic keratoconjunctivitis. ( 4051856 )
1985
47
Superior limbic keratoconjunctivitis. ( 6721747 )
1984
48
Conjunctival resection for superior limbic keratoconjunctivitis. ( 6493706 )
1984
49
Superior limbic keratoconjunctivitis associated with cosmetic soft contact lens wear. ( 6882249 )
1983
50
Superior limbic keratoconjunctivitis. ( 6626019 )
1983

Variations for Superior Limbic Keratoconjunctivitis

Expression for Superior Limbic Keratoconjunctivitis

Search GEO for disease gene expression data for Superior Limbic Keratoconjunctivitis.

Pathways for Superior Limbic Keratoconjunctivitis

GO Terms for Superior Limbic Keratoconjunctivitis

Cellular components related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.62 MMP1 MMP3

Biological processes related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.26 MMP1 MMP3
2 extracellular matrix disassembly GO:0022617 9.16 MMP1 MMP3
3 collagen catabolic process GO:0030574 8.96 MMP1 MMP3
4 positive regulation of protein oligomerization GO:0032461 8.62 MMP1 MMP3

Molecular functions related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.32 MMP1 MMP3
2 serine-type endopeptidase activity GO:0004252 9.26 MMP1 MMP3
3 metallopeptidase activity GO:0008237 9.16 MMP1 MMP3
4 metalloendopeptidase activity GO:0004222 8.96 MMP1 MMP3
5 endopeptidase activity GO:0004175 8.62 MMP1 MMP3

Sources for Superior Limbic Keratoconjunctivitis

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