MCID: SPR034
MIFTS: 36

Superior Limbic Keratoconjunctivitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Superior Limbic Keratoconjunctivitis

MalaCards integrated aliases for Superior Limbic Keratoconjunctivitis:

Name: Superior Limbic Keratoconjunctivitis 54 60 74
Slk 54 60
Theodore's Superior Limbic Keratoconjunctivitis 60
Theodores Superior Limbic Keratoconjunctivitis 54
Theodore's Syndrome 60
Theodores Syndrome 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 60  
Rare eye diseases


External Ids:

ICD10 via Orphanet 35 H16.2
UMLS via Orphanet 75 C0339229
Orphanet 60 ORPHA88633
UMLS 74 C0339229

Summaries for Superior Limbic Keratoconjunctivitis

NIH Rare Diseases : 54 Superior limbic keratoconjunctivitis (SLK) is a chronic and recurrent eye disease which affects the superior bulbar conjunctiva (the clear layer that covers the eyeball, over the sclera) and tarsal conjunctiva (the clear layer that lines the eyelids), as well as the superior limbic aspect of the cornea (the area above the cornea). It is commonly found in women 20-70 years of age. The signs and symptoms include burning, redness and irritation and tend to develop slowly over a period of 1 to 10 years. Vision usually remains intact. While the underlying cause of SLK remains unknown, it is believed that the condition is secondary to superior bulbar conjunctiva laxity.  Factors inducing conjunctiva laxity include  thyroid eye disease (usually hyperthyroidism), tight upper eyelids, and prominent globes. A mimicking disorder has been encountered in soft contact lens (SCL) wearers, typically with exposure to thimerosal-preserved solutions. Treatment of SLK may involve the use of various medications, surgery, or a combination of both.

MalaCards based summary : Superior Limbic Keratoconjunctivitis, also known as slk, is related to conjunctivochalasis and robinow syndrome, autosomal dominant 1. An important gene associated with Superior Limbic Keratoconjunctivitis is MMP1 (Matrix Metallopeptidase 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and IL-17 Family Signaling Pathways. Affiliated tissues include eye, thyroid and kidney.

Wikipedia : 77 Superior limbic keratoconjunctivitis is an ocular disease characterized by episodes of recurrent... more...

Related Diseases for Superior Limbic Keratoconjunctivitis

Diseases related to Superior Limbic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 conjunctivochalasis 29.9 MMP1 MMP3
2 robinow syndrome, autosomal dominant 1 11.3
3 autoimmune glomerulonephritis 11.3
4 keratoconjunctivitis 11.0
5 kaposi sarcoma 10.2
6 sarcoma 10.2
7 graft-versus-host disease 10.1
8 graves' disease 10.1
9 giant papillary conjunctivitis 10.1
10 papillary conjunctivitis 10.1
11 sebaceous adenocarcinoma 10.1
12 conjunctivitis 10.1
13 eyelid carcinoma 10.1
14 chronic graft versus host disease 10.1
15 cytokine deficiency 10.1
16 breast cancer 10.0
17 polyglucosan body myopathy 1 with or without immunodeficiency 10.0
18 muscle disorders 10.0
19 myopathy 10.0
20 spindle cell sarcoma 10.0
21 spastic entropion 9.9 MMP1 MMP3
22 tendinopathy 9.9 MMP1 MMP3
23 adult astrocytic tumour 9.9 MMP1 MMP3
24 corneal edema 9.9 MMP1 MMP3
25 epidermolysis bullosa dystrophica 9.9 MMP1 MMP3
26 tendinosis 9.9 MMP1 MMP3
27 coronary artery aneurysm 9.9 MMP1 MMP3
28 lymph node disease 9.9 MMP1 MMP3
29 aortic aneurysm, familial abdominal, 1 9.9 MMP1 MMP3
30 gingival fibromatosis 9.8 MMP1 MMP3
31 carotid artery disease 9.8 MMP1 MMP3
32 varicose veins 9.8 MMP1 MMP3
33 bone inflammation disease 9.8 MMP1 MMP3
34 gingival overgrowth 9.8 MMP1 MMP3
35 synovitis 9.8 MMP1 MMP3
36 periodontitis 9.8 MMP1 MMP3
37 periodontal disease 9.8 MMP1 MMP3
38 chondrosarcoma 9.8 MMP1 MMP3
39 psoriatic arthritis 9.8 MMP1 MMP3
40 arthritis 9.7 MMP1 MMP3
41 fibrosarcoma 9.7 MMP1 MMP3
42 osteoarthritis 9.7 MMP1 MMP3
43 rheumatoid arthritis 9.6 MMP1 MMP3
44 ewing sarcoma 9.5 MMP1 MMP3

Graphical network of the top 20 diseases related to Superior Limbic Keratoconjunctivitis:



Diseases related to Superior Limbic Keratoconjunctivitis

Symptoms & Phenotypes for Superior Limbic Keratoconjunctivitis

Drugs & Therapeutics for Superior Limbic Keratoconjunctivitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Pathogenesis of Superior Limbic Keratoconjunctivitis Unknown status NCT00167050
2 The Role of Cytokines and Mast Cell in the Pathogenesis of SLK, Conjunctivochalasis, and Dry Eye Unknown status NCT02160327
3 Diadenosine Polyphosphates and Mucin Associated With Ocular Surface Disorders Recruiting NCT03731624

Search NIH Clinical Center for Superior Limbic Keratoconjunctivitis

Genetic Tests for Superior Limbic Keratoconjunctivitis

Anatomical Context for Superior Limbic Keratoconjunctivitis

MalaCards organs/tissues related to Superior Limbic Keratoconjunctivitis:

42
Eye, Thyroid, Kidney, Endothelial, Skeletal Muscle, Bone, Lymph Node

Publications for Superior Limbic Keratoconjunctivitis

Articles related to Superior Limbic Keratoconjunctivitis:

(show top 50) (show all 110)
# Title Authors Year
1
Tear cytokine profiling in patients with superior limbic keratoconjunctivitis who underwent medical treatment or in conjunction with surgical management. ( 30926588 )
2019
2
Efficacy and safety of 0.1% lodoxamide for the long-term treatment of superior limbic keratoconjunctivitis. ( 28602013 )
2018
3
Clinical Severity Classification using Automated Conjunctival Hyperemia Analysis Software in Patients with Superior Limbic Keratoconjunctivitis. ( 29336627 )
2018
4
High Inflammatory Infiltrate Correlates With Poor Symptomatic Improvement After Surgical Treatment for Superior Limbic Keratoconjunctivitis. ( 29346129 )
2018
5
MicroRNA-126 regulates the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) pathway in SLK cells in vitro and the expression of its pathway members in Kaposi's sarcoma tissue. ( 30170375 )
2018
6
Ste20-like kinase, SLK, a novel mediator of podocyte integrity. ( 29187370 )
2018
7
Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness. ( 28153048 )
2017
8
Regulation of Ste20-like kinase, SLK, activity: Dimerization and activation segment phosphorylation. ( 28475647 )
2017
9
Transforming growth factor β-induced epithelial to mesenchymal transition requires the Ste20-like kinase SLK independently of its catalytic activity. ( 29228724 )
2017
10
Superior Limbic Keratoconjunctivitis-like Inflammation in Patients with Chronic Graft-Versus-Host Disease. ( 27179980 )
2016
11
SLK/LOSK kinase regulates cell motility independently of microtubule organization and Golgi polarization. ( 26818812 )
2016
12
Simultaneous Liver Kidney Transplant (SLK) Allocation Policy Change Proposal: Is It Really a Smart Move? ( 27129113 )
2016
13
Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway. ( 27216364 )
2016
14
Extensive superior limbic keratoconjunctivitis in Graves' disease: case report and mini-review of the literature. ( 25792798 )
2015
15
Stem Cell Factor and Thymic Stromal Lymphopoietin Overexpression With Correlation to Mast Cells in Superior Limbic Keratoconjunctivitis. ( 26382891 )
2015
16
Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4. ( 25882817 )
2015
17
Identification of Tpr and α-actinin-4 as two novel SLK-interacting proteins. ( 26094769 )
2015
18
Surgical approach with high-frequency radiowave electrosurgery for superior limbic keratoconjunctivitis. ( 24322803 )
2014
19
Topical rebamipide treatment for superior limbic keratoconjunctivitis in patients with thyroid eye disease. ( 24412123 )
2014
20
Essential role for the SLK protein kinase in embryogenesis and placental tissue development. ( 24868594 )
2014
21
SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation. ( 24958772 )
2014
22
Treatment of superior limbic keratoconjunctivitis with topical tacrolimus 0.03% ointment. ( 23770977 )
2013
23
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. ( 23791418 )
2013
24
Kaposi's sarcoma-derived cell line SLK is not of endothelial origin, but is a contaminant from a known renal carcinoma cell line. ( 22987579 )
2013
25
SLK-mediated phosphorylation of paxillin is required for focal adhesion turnover and cell migration. ( 23128389 )
2013
26
Ste20-like kinase SLK, at the crossroads: a matter of life and death. ( 23154402 )
2013
27
Distinct roles for Ste20-like kinase SLK in muscle function and regeneration. ( 23815977 )
2013
28
Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome. ( 23985322 )
2013
29
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. ( 23158547 )
2012
30
Regulation of the Ste20-like kinase, SLK: involvement of activation segment phosphorylation. ( 22203681 )
2012
31
Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells. ( 23209304 )
2012
32
Comparison of ESWL outcome between Wolf Piezolith 3000 vs. storz Modulith Slk. it is the man who makes efficient the machine. ( 23427761 )
2012
33
Overexpression of matrix metalloproteinase-1 (MMP-1) and MMP-3 in superior limbic keratoconjunctivitis. ( 21357403 )
2011
34
Ocular surface squamous neoplasia masquerading as superior limbic keratoconjunctivitis. ( 21572741 )
2011
35
Sulfated polymannuroguluronate inhibits Tat-induced SLK cell adhesion via a novel binding site, a KKR spatial triad. ( 21499289 )
2011
36
Activity of the Ste20-like kinase, SLK, is enhanced by homodimerization. ( 21677149 )
2011
37
In vivo evaluation of superior limbic keratoconjunctivitis using laser scanning confocal microscopy and conjunctival impression cytology. ( 20375341 )
2010
38
Conjunctival resection with and without amniotic membrane graft for the treatment of superior limbic keratoconjunctivitis. ( 20539210 )
2010
39
Podocyte injury and albuminuria in mice with podocyte-specific overexpression of the Ste20-like kinase, SLK. ( 20889563 )
2010
40
Treatment of superior limbic keratoconjunctivitis with a large-diameter contact lens and Botulium Toxin A. ( 19574913 )
2009
41
Conjunctival fixation sutures for refractory superior limbic keratoconjunctivitis. ( 18812388 )
2009
42
Liquid nitrogen cryotherapy of superior limbic keratoconjunctivitis. ( 18835475 )
2009
43
The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration. ( 19675209 )
2009
44
A novel role for the Ste20 kinase SLK in adhesion signaling and cell migration. ( 19262175 )
2009
45
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility. ( 19525980 )
2009
46
The Ste20-like kinase SLK promotes p53 transactivation and apoptosis. ( 19640899 )
2009
47
Conjunctival resection combined with tenon layer excision and the involvement of mast cells in superior limbic keratoconjunctivitis. ( 18201682 )
2008
48
Topical cyclosporine a in the treatment of superior limbic keratoconjunctivitis: a long-term follow-up. ( 18216575 )
2008
49
Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase. ( 18287541 )
2008
50
Plk1 activation by Ste20-like kinase (Slk) phosphorylation and polo-box phosphopeptide binding assayed with the substrate translationally controlled tumor protein (TCTP). ( 18298087 )
2008

Variations for Superior Limbic Keratoconjunctivitis

Expression for Superior Limbic Keratoconjunctivitis

Search GEO for disease gene expression data for Superior Limbic Keratoconjunctivitis.

Pathways for Superior Limbic Keratoconjunctivitis

GO Terms for Superior Limbic Keratoconjunctivitis

Cellular components related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.62 MMP1 MMP3

Biological processes related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.32 MMP1 MMP3
2 cytokine-mediated signaling pathway GO:0019221 9.26 MMP1 MMP3
3 extracellular matrix disassembly GO:0022617 9.16 MMP1 MMP3
4 collagen catabolic process GO:0030574 8.96 MMP1 MMP3
5 positive regulation of protein oligomerization GO:0032461 8.62 MMP1 MMP3

Molecular functions related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.32 MMP1 MMP3
2 serine-type endopeptidase activity GO:0004252 9.26 MMP1 MMP3
3 metallopeptidase activity GO:0008237 9.16 MMP1 MMP3
4 metalloendopeptidase activity GO:0004222 8.96 MMP1 MMP3
5 endopeptidase activity GO:0004175 8.62 MMP1 MMP3

Sources for Superior Limbic Keratoconjunctivitis

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