SLK
MCID: SPR034
MIFTS: 35

Superior Limbic Keratoconjunctivitis (SLK)

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Superior Limbic Keratoconjunctivitis

MalaCards integrated aliases for Superior Limbic Keratoconjunctivitis:

Name: Superior Limbic Keratoconjunctivitis 54 60 74
Slk 54 60
Theodore's Superior Limbic Keratoconjunctivitis 60
Theodores Superior Limbic Keratoconjunctivitis 54
Theodore's Syndrome 60
Theodores Syndrome 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 60  
Rare eye diseases


External Ids:

ICD10 via Orphanet 35 H16.2
UMLS via Orphanet 75 C0339229
Orphanet 60 ORPHA88633
UMLS 74 C0339229

Summaries for Superior Limbic Keratoconjunctivitis

NIH Rare Diseases : 54 Superior limbic keratoconjunctivitis (SLK) is a chronic and recurrent eye disease which affects the superior bulbar conjunctiva (the clear layer that covers the eyeball, over the sclera) and tarsal conjunctiva (the clear layer that lines the eyelids), as well as the superior limbic aspect of the cornea (the area above the cornea). It is commonly found in women 20-70 years of age. The signs and symptoms include burning, redness and irritation and tend to develop slowly over a period of 1 to 10 years. Vision usually remains intact. While the underlying cause of SLK remains unknown, it is believed that the condition is secondary to superior bulbar conjunctiva laxity.  Factors inducing conjunctiva laxity include  thyroid eye disease (usually hyperthyroidism), tight upper eyelids, and prominent globes. A mimicking disorder has been encountered in soft contact lens (SCL) wearers, typically with exposure to thimerosal-preserved solutions. Treatment of SLK may involve the use of various medications, surgery, or a combination of both.

MalaCards based summary : Superior Limbic Keratoconjunctivitis, also known as slk, is related to conjunctivochalasis and robinow syndrome, autosomal dominant 1. An important gene associated with Superior Limbic Keratoconjunctivitis is MMP1 (Matrix Metallopeptidase 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and IL-17 Family Signaling Pathways. Affiliated tissues include eye, thyroid and kidney.

Wikipedia : 77 Superior limbic keratoconjunctivitis is an ocular disease characterized by episodes of recurrent... more...

Related Diseases for Superior Limbic Keratoconjunctivitis

Diseases related to Superior Limbic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 conjunctivochalasis 29.9 MMP1 MMP3
2 robinow syndrome, autosomal dominant 1 11.3
3 autoimmune glomerulonephritis 11.3
4 keratoconjunctivitis 11.0
5 sarcoma 10.2
6 graft-versus-host disease 10.1
7 graves' disease 10.1
8 giant papillary conjunctivitis 10.1
9 papillary conjunctivitis 10.1
10 conjunctivitis 10.1
11 chronic graft versus host disease 10.1
12 breast cancer 10.0
13 kaposi sarcoma 10.0
14 polyglucosan body myopathy 1 with or without immunodeficiency 10.0
15 muscle disorders 10.0
16 myopathy 10.0
17 spindle cell sarcoma 10.0
18 spastic entropion 9.9 MMP1 MMP3
19 tendinopathy 9.9 MMP1 MMP3
20 adult astrocytic tumour 9.9 MMP1 MMP3
21 corneal edema 9.9 MMP1 MMP3
22 epidermolysis bullosa dystrophica 9.9 MMP1 MMP3
23 tendinosis 9.9 MMP1 MMP3
24 coronary artery aneurysm 9.9 MMP1 MMP3
25 lymph node disease 9.9 MMP1 MMP3
26 aortic aneurysm, familial abdominal, 1 9.9 MMP1 MMP3
27 gingival fibromatosis 9.8 MMP1 MMP3
28 carotid artery disease 9.8 MMP1 MMP3
29 varicose veins 9.8 MMP1 MMP3
30 bone inflammation disease 9.8 MMP1 MMP3
31 gingival overgrowth 9.8 MMP1 MMP3
32 synovitis 9.8 MMP1 MMP3
33 periodontitis 9.8 MMP1 MMP3
34 periodontal disease 9.8 MMP1 MMP3
35 chondrosarcoma 9.8 MMP1 MMP3
36 psoriatic arthritis 9.8 MMP1 MMP3
37 arthritis 9.7 MMP1 MMP3
38 fibrosarcoma 9.7 MMP1 MMP3
39 osteoarthritis 9.7 MMP1 MMP3
40 rheumatoid arthritis 9.6 MMP1 MMP3
41 ewing sarcoma 9.5 MMP1 MMP3

Graphical network of the top 20 diseases related to Superior Limbic Keratoconjunctivitis:



Diseases related to Superior Limbic Keratoconjunctivitis

Symptoms & Phenotypes for Superior Limbic Keratoconjunctivitis

Drugs & Therapeutics for Superior Limbic Keratoconjunctivitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Pathogenesis of Superior Limbic Keratoconjunctivitis Unknown status NCT00167050
2 The Role of Cytokines and Mast Cell in the Pathogenesis of SLK, Conjunctivochalasis, and Dry Eye Unknown status NCT02160327
3 Diadenosine Polyphosphates and Mucin Associated With Ocular Surface Disorders Recruiting NCT03731624

Search NIH Clinical Center for Superior Limbic Keratoconjunctivitis

Genetic Tests for Superior Limbic Keratoconjunctivitis

Anatomical Context for Superior Limbic Keratoconjunctivitis

MalaCards organs/tissues related to Superior Limbic Keratoconjunctivitis:

42
Eye, Thyroid, Kidney, Skeletal Muscle

Publications for Superior Limbic Keratoconjunctivitis

Articles related to Superior Limbic Keratoconjunctivitis:

(show top 50) (show all 87)
# Title Authors Year
1
High Inflammatory Infiltrate Correlates With Poor Symptomatic Improvement After Surgical Treatment for Superior Limbic Keratoconjunctivitis. ( 29346129 )
2018
2
Clinical Severity Classification using Automated Conjunctival Hyperemia Analysis Software in Patients with Superior Limbic Keratoconjunctivitis. ( 29336627 )
2018
3
MicroRNA-126 regulates the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) pathway in SLK cells in vitro and the expression of its pathway members in Kaposi's sarcoma tissue. ( 30170375 )
2018
4
Ste20-like kinase, SLK, a novel mediator of podocyte integrity. ( 29187370 )
2018
5
Efficacy and safety of 0.1% lodoxamide for the long-term treatment of superior limbic keratoconjunctivitis. ( 28602013 )
2017
6
Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness. ( 28153048 )
2017
7
Regulation of Ste20-like kinase, SLK, activity: Dimerization and activation segment phosphorylation. ( 28475647 )
2017
8
Transforming growth factor β-induced epithelial to mesenchymal transition requires the Ste20-like kinase SLK independently of its catalytic activity. ( 29228724 )
2017
9
Superior Limbic Keratoconjunctivitis-like Inflammation in Patients with Chronic Graft-Versus-Host Disease. ( 27179980 )
2016
10
Simultaneous Liver Kidney Transplant (SLK) Allocation Policy Change Proposal: Is It Really a Smart Move? ( 27129113 )
2016
11
Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway. ( 27216364 )
2016
12
Extensive superior limbic keratoconjunctivitis in Graves' disease: case report and mini-review of the literature. ( 25792798 )
2015
13
Stem Cell Factor and Thymic Stromal Lymphopoietin Overexpression With Correlation to Mast Cells in Superior Limbic Keratoconjunctivitis. ( 26382891 )
2015
14
Surgical approach with high-frequency radiowave electrosurgery for superior limbic keratoconjunctivitis. ( 24322803 )
2014
15
Topical Rebamipide Treatment for Superior Limbic Keratoconjunctivitis in Patients with Thyroid Eye Disease. ( 24412123 )
2014
16
Essential role for the SLK protein kinase in embryogenesis and placental tissue development. ( 24868594 )
2014
17
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. ( 23791418 )
2013
18
Treatment of superior limbic keratoconjunctivitis with topical tacrolimus 0.03% ointment. ( 23770977 )
2013
19
Ste20-like kinase SLK, at the crossroads: a matter of life and death. ( 23154402 )
2013
20
Distinct roles for Ste20-like kinase SLK in muscle function and regeneration. ( 23815977 )
2013
21
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. ( 23158547 )
2012
22
Comparison of ESWL outcome between Wolf Piezolith 3000 vs. storz Modulith Slk. it is the man who makes efficient the machine. ( 23427761 )
2012
23
Overexpression of matrix metalloproteinase-1 (MMP-1) and MMP-3 in superior limbic keratoconjunctivitis. ( 21357403 )
2011
24
Ocular surface squamous neoplasia masquerading as superior limbic keratoconjunctivitis. ( 21572741 )
2011
25
Sulfated polymannuroguluronate inhibits Tat-induced SLK cell adhesion via a novel binding site, a KKR spatial triad. ( 21499289 )
2011
26
Activity of the Ste20-like kinase, SLK, is enhanced by homodimerization. ( 21677149 )
2011
27
Conjunctival resection with and without amniotic membrane graft for the treatment of superior limbic keratoconjunctivitis. ( 20539210 )
2010
28
In vivo evaluation of superior limbic keratoconjunctivitis using laser scanning confocal microscopy and conjunctival impression cytology. ( 20375341 )
2010
29
Podocyte injury and albuminuria in mice with podocyte-specific overexpression of the Ste20-like kinase, SLK. ( 20889563 )
2010
30
Liquid nitrogen cryotherapy of superior limbic keratoconjunctivitis. ( 18835475 )
2009
31
Treatment of superior limbic keratoconjunctivitis with a large-diameter contact lens and Botulium Toxin A. ( 19574913 )
2009
32
Conjunctival fixation sutures for refractory superior limbic keratoconjunctivitis. ( 18812388 )
2009
33
A novel role for the Ste20 kinase SLK in adhesion signaling and cell migration. ( 19262175 )
2009
34
Topical cyclosporine a in the treatment of superior limbic keratoconjunctivitis: a long-term follow-up. ( 18216575 )
2008
35
Conjunctival resection combined with tenon layer excision and the involvement of mast cells in superior limbic keratoconjunctivitis. ( 18201682 )
2008
36
Proceedings of Consensus Conference on Simultaneous Liver Kidney Transplantation (SLK). ( 18808402 )
2008
37
Development of superior limbic keratoconjunctivitis after upper eyelid blepharoplasty surgery: support for the mechanical theory of its pathogenesis. ( 17457203 )
2007
38
Supratarsal triamcinolone injection in the treatment of superior limbic keratoconjunctivitis. ( 17457190 )
2007
39
Acute and long-term outcomes of the novel side access (SLK-View) stent for bifurcation coronary lesions: a multicenter nonrandomized feasibility study. ( 16404749 )
2006
40
The Ste20-like kinase SLK is required for cell cycle progression through G2. ( 16236704 )
2005
41
LOSK (SLK) protein kinase activity is necessary for microtubule organization in the interphase cell centrosome. ( 16358584 )
2005
42
Ste20-like kinase SLK displays myofiber type specificity and is involved in C2C12 myoblast differentiation. ( 15052621 )
2004
43
Topical cyclosporine A 0.5% as a possible new treatment for superior limbic keratoconjunctivitis. ( 12917176 )
2003
44
New surgical treatment for superior limbic keratoconjunctivitis and its association with conjunctivochalasis. ( 12614746 )
2003
45
Treatment of superior limbic keratoconjunctivitis with a unilateral bandage contact lens. ( 11914237 )
2002
46
Ketotifen fumarate treatment of superior limbic keratoconjunctivitis. ( 12410035 )
2002
47
Expression of the Ste20-like kinase SLK during embryonic development and in the murine adult central nervous system. ( 12480135 )
2002
48
Treatment of superior limbic keratoconjunctivitis by application of autologous serum. ( 11685056 )
2001
49
Superior limbic keratoconjunctivitis: multifactorial mechanical pathogenesis. ( 10981793 )
2000
50
TGF-beta2, tenascin, and integrin beta1 expression in superior limbic keratoconjunctivitis. ( 10482468 )
1999

Variations for Superior Limbic Keratoconjunctivitis

Expression for Superior Limbic Keratoconjunctivitis

Search GEO for disease gene expression data for Superior Limbic Keratoconjunctivitis.

Pathways for Superior Limbic Keratoconjunctivitis

GO Terms for Superior Limbic Keratoconjunctivitis

Cellular components related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.62 MMP1 MMP3

Biological processes related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.32 MMP1 MMP3
2 cytokine-mediated signaling pathway GO:0019221 9.26 MMP1 MMP3
3 extracellular matrix disassembly GO:0022617 9.16 MMP1 MMP3
4 collagen catabolic process GO:0030574 8.96 MMP1 MMP3
5 positive regulation of protein oligomerization GO:0032461 8.62 MMP1 MMP3

Molecular functions related to Superior Limbic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.32 MMP1 MMP3
2 serine-type endopeptidase activity GO:0004252 9.26 MMP1 MMP3
3 metallopeptidase activity GO:0008237 9.16 MMP1 MMP3
4 metalloendopeptidase activity GO:0004222 8.96 MMP1 MMP3
5 endopeptidase activity GO:0004175 8.62 MMP1 MMP3

Sources for Superior Limbic Keratoconjunctivitis

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