MCID: SPR007
MIFTS: 42

Superior Mesenteric Artery Syndrome

Categories: Rare diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Superior Mesenteric Artery Syndrome

MalaCards integrated aliases for Superior Mesenteric Artery Syndrome:

Name: Superior Mesenteric Artery Syndrome 12 76 53 44 15 73
Arteriomesenteric Compression of Duodenojejunal Flexure 73
Arteriomesenteric Duodenal Compression Syndrome 53
Vascular Compression of the Duodenum 53
Wilkie Syndrome 53
Cast Syndrome 53

Classifications:



External Ids:

Disease Ontology 12 DOID:3557
MeSH 44 D013478
NCIt 50 C85175
SNOMED-CT 68 197006009 24988007

Summaries for Superior Mesenteric Artery Syndrome

NIH Rare Diseases : 53 Superior mesenteric artery syndrome (SMAS) is a digestive condition that occurs when the duodenum (the first part of the small intestine) is compressed between two arteries (the aorta and the superior mesenteric artery). This compression causes partial or complete blockage of the duodenum. Symptoms vary based on severity, but can be severely debilitating. Symptoms may include abdominal pain, fullness, nausea, vomiting, and/or weight loss. SMAS typically is due to loss of the mesenteric fat pad (fatty tissue that surrounds the superior mesenteric artery). The most common cause is significant weight loss caused by medical disorders, psychological disorders, or surgery. In younger patients, it most commonly occurs after corrective spinal surgery for scoliosis. Delays in diagnosis may result in significant complications. Depending on the cause and severity, treatment options may include addressing the underlying cause, dietary changes (small feedings or a liquid diet), and/or surgery. Symptoms may not resolve completely after treatment.

MalaCards based summary : Superior Mesenteric Artery Syndrome, also known as arteriomesenteric compression of duodenojejunal flexure, is related to duodenitis and hernia, hiatus, and has symptoms including abdominal angina An important gene associated with Superior Mesenteric Artery Syndrome is KRT17 (Keratin 17), and among its related pathways/superpathways are Diseases of glycosylation and Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS). Affiliated tissues include small intestine, brain and spinal cord, and related phenotype is digestive/alimentary.

Wikipedia : 76 Superior mesenteric artery (SMA) syndrome is a gastro-vascular disorder in which the third and final... more...

Related Diseases for Superior Mesenteric Artery Syndrome

Diseases related to Superior Mesenteric Artery Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
# Related Disease Score Top Affiliating Genes
1 duodenitis 31.7 ATP12A ATP4A
2 hernia, hiatus 30.7 ATP12A ATP4A
3 renal nutcracker syndrome 11.5
4 fungal esophagitis 10.8 ATP12A ATP4A
5 gastrointestinal neuroendocrine benign tumor 10.8 ATP12A ATP4A
6 pancreatic intraductal papillary-mucinous neoplasm 10.8 MUC2 MUC6
7 neonatal candidiasis 10.8 ATP12A ATP4A
8 photoallergic dermatitis 10.8 ATP12A ATP4A
9 squamous papillomatosis 10.8 ATP12A ATP4A
10 acute laryngitis 10.8 ATP12A ATP4A
11 gastroduodenal crohn's disease 10.8 ATP12A ATP4A
12 tumor of exocrine pancreas 10.8 MUC2 MUC6
13 gastric neuroendocrine neoplasm 10.8 ATP12A ATP4A
14 toxic megacolon 10.8 ATP12A ATP4A
15 aspiration pneumonitis 10.8 ATP12A ATP4A
16 postsurgical hypothyroidism 10.8 ATP12A ATP4A
17 gastric antral vascular ectasia 10.8 ATP12A ATP4A
18 esophageal candidiasis 10.8 ATP12A ATP4A
19 granulomatous gastritis 10.7 ATP12A ATP4A
20 tn polyagglutination syndrome 10.7 MUC2 MUC6
21 active peptic ulcer disease 10.7 ATP12A ATP4A
22 laryngeal disease 10.7 ATP12A ATP4A
23 capillary disease 10.7 ATP12A ATP4A
24 peptic esophagitis 10.7 ATP12A ATP4A
25 duodenal disease 10.7 ATP12A ATP4A
26 dyskinesia of esophagus 10.7 ATP12A ATP4A
27 congenital disorder of deglycosylation 10.7 ATP12A ATP4A
28 anismus 10.7 ATP12A ATP4A
29 esophageal atresia/tracheoesophageal fistula 10.7 ATP12A ATP4A
30 laryngitis 10.7 ATP12A ATP4A
31 laryngeal tuberculosis 10.7 ATP12A ATP4A
32 lymphocytic colitis 10.7 ATP12A ATP4A
33 clostridium difficile colitis 10.7 ATP12A ATP4A
34 aspiration pneumonia 10.6 ATP12A ATP4A
35 sphenoid sinusitis 10.6 AVP PGRMC1
36 diarrhea 1, secretory chloride, congenital 10.6 ATP12A ATP4A
37 chronic intestinal vascular insufficiency 10.6 ATP12A ATP4A
38 ovarian mucinous adenocarcinoma 10.6 CDX2 MUC2
39 chronic cholangitis 10.6 CDX2 MUC2
40 eosinophilic gastritis 10.6 ATP12A ATP4A
41 esophageal varix 10.6 ATP12A ATP4A
42 esophagus adenocarcinoma 10.5 ATP12A ATP4A
43 endocervical adenocarcinoma 10.5 CDX2 MUC6
44 bladder calculus 10.5 ATP12A ATP4A PGRMC1
45 myopathy, x-linked, with excessive autophagy 10.5 ATP12A ATP4A
46 lower urinary tract calculus 10.5 ATP12A ATP4A PGRMC1
47 motion sickness 10.5 AVP HTR3A
48 ischemic neuropathy 10.5 ATP12A ATP4A PMAIP1
49 anal paget's disease 10.5 CDX2 CEACAM5
50 rumination disorder 10.5 ATP12A ATP4A HTR3A

Graphical network of the top 20 diseases related to Superior Mesenteric Artery Syndrome:



Diseases related to Superior Mesenteric Artery Syndrome

Symptoms & Phenotypes for Superior Mesenteric Artery Syndrome

UMLS symptoms related to Superior Mesenteric Artery Syndrome:


abdominal angina

MGI Mouse Phenotypes related to Superior Mesenteric Artery Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.23 ATP12A ATP4A CDX2 KRT17 KRT19 MUC2

Drugs & Therapeutics for Superior Mesenteric Artery Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 SMAS: a Prospective Study in a Single Institution Completed NCT03416647 Not Applicable

Search NIH Clinical Center for Superior Mesenteric Artery Syndrome

Cochrane evidence based reviews: superior mesenteric artery syndrome

Genetic Tests for Superior Mesenteric Artery Syndrome

Anatomical Context for Superior Mesenteric Artery Syndrome

MalaCards organs/tissues related to Superior Mesenteric Artery Syndrome:

41
Small Intestine, Brain, Spinal Cord, Testes, B Cells, Pancreas, Colon

Publications for Superior Mesenteric Artery Syndrome

Articles related to Superior Mesenteric Artery Syndrome:

(show top 50) (show all 392)
# Title Authors Year
1
Robotic Strong's procedure for the treatment of superior mesenteric artery syndrome. Description of surgical technique on occasion of the first reported case in the literature. ( 29168288 )
2018
2
A Rare Cause and Complication of Acute Gastric Dilatation: Superior Mesenteric Artery Syndrome and Perforation. ( 29531498 )
2018
3
Superior Mesenteric Artery Syndrome ( 29489172 )
2018
4
Superior Mesenteric Artery Syndrome: An Uncommon Cause of Abdominal Pain. ( 29336988 )
2018
5
Superior Mesenteric Artery Syndrome in Patients with Crohn's Disease: A Description of 2 Cases Studied with a Novel Magnetic Resonance Enterography (MRE) Procedure. ( 29643328 )
2018
6
Case report of gastric distension due to superior mesenteric artery syndrome mimicking hollow viscus perforation: Considerations in critical care ultrasound. ( 29768359 )
2018
7
Superior mesenteric artery syndrome: quality of life after laparoscopic duodenojejunostomy. ( 29445471 )
2018
8
Superior mesenteric artery syndrome in an 18-year old female: Case report. ( 29540902 )
2018
9
A Case Series on Superior Mesenteric Artery Syndrome Surgical Management, Single Institution Experience. ( 28969208 )
2017
10
Unusual Mechanism for Superior Mesenteric Artery Syndrome after Scoliosis Surgery. ( 28759898 )
2017
11
Clinical and Radiologic Considerations for Idiopathic Superior Mesenteric Artery Syndrome. ( 29321946 )
2017
12
Superior mesenteric artery syndrome: A rare but life threatening disease. ( 28616620 )
2017
13
Superior Mesenteric Artery Syndrome May Be Overlooked in Women with Functional Dyspepsia. ( 28883239 )
2017
14
Superior mesenteric artery syndrome after lung transplantation: a rare early gastrointestinal complication of lung transplantation. ( 28364397 )
2017
15
Superior Mesenteric Artery Syndrome Combined with Renal Nutcracker Syndrome in a Young Male: A Case Report. ( 29277094 )
2017
16
A Rare Case of Coexisting Superior Mesenteric Artery Syndrome and Nutcracker Phenomenon. ( 29062567 )
2017
17
Intestinal atresia following chemotherapy, presenting as superior mesenteric artery syndrome: A case report. ( 28855988 )
2017
18
Wilkie Syndrome behind Crohn Disease? Superior Mesenteric Artery Syndrome Mimicking and Complicating Crohn Disease of the Upper Gastrointestinal Tract. ( 28848781 )
2017
19
Superior mesenteric artery syndrome: A diagnosis to be kept in mind (Case report and literature review). ( 28376419 )
2017
20
Superior Mesenteric Artery Syndrome Improved by Enteral Nutritional Therapy according to the Controlling Nutritional Status Score. ( 29430225 )
2017
21
Superior Mesenteric Artery Syndrome: Weight Loss Can Be a Problem, Weight Gain Can Be a Solution. ( 28848779 )
2017
22
Superior Mesenteric Artery Syndrome Associated with Abdominal Aortic Aneurysm. ( 28256350 )
2017
23
Superior mesenteric artery syndrome: a single centre experience of laparoscopic duodenojejunostomy as the operation of choice. ( 28660836 )
2017
24
Superior mesenteric artery syndrome: an uncommon cause of intestinal obstruction. ( 28100055 )
2017
25
The two sides of superior mesenteric artery syndrome treatment: conservative or surgical management? ( 29095027 )
2017
26
Superior Mesenteric Artery Syndrome in association with Abdominal Tuberculosis: An Eye Opener. ( 28814938 )
2017
27
Unusual delayed presentation of superior mesenteric artery syndrome following scoliosis correction surgery-a case report and review of literature. ( 28744512 )
2017
28
Superior Mesenteric Artery Syndrome as a Complication of Scoliosis Surgery. ( 28437498 )
2017
29
Anorexia nervosa complicated with hiatal hernia and superior mesenteric artery syndrome: A case illustrating the risk of inference observation confusion. ( 29264011 )
2017
30
Significant gastric distension caused by superior mesenteric artery syndrome or Wilkie's syndrome. ( 28434785 )
2017
31
Superior mesenteric artery syndrome in a healthy adolescent. ( 28637846 )
2017
32
Increase body weight to treat superior mesenteric artery syndrome. ( 28576908 )
2017
33
Superior Mesenteric Artery Syndrome Combined with Renal Nutcracker Syndrome in a Young Male: A Case Report. ( 29161795 )
2017
34
Superior mesenteric artery syndrome leading to reversible mucosal gangrene. ( 29123896 )
2017
35
Superior mesenteric artery syndrome in a young woman. ( 28270402 )
2017
36
Superior Mesenteric Artery Syndrome after Kyphosis Correction - A Case Report. ( 29242799 )
2017
37
Superior Mesenteric Artery Syndrome: The Dark Side of Weight Loss. ( 29375945 )
2017
38
Superior Mesenteric Artery Syndrome Presented with Parkinson's Disease. ( 27523019 )
2016
39
Severe malnutrition causing superior mesenteric artery syndrome in an adolescent with Triple A syndrome. ( 27682707 )
2016
40
Laparoscopic duodenojejunostomy for superior mesenteric artery syndrome: intermediate follow-up results and a review of the literature. ( 27405482 )
2016
41
Superior Mesenteric Artery Syndrome Treated with Percutaneous Radiologic Gastrojejunostomy. ( 27312833 )
2016
42
Primary adenocarcinoma of the small intestine presenting as superior mesenteric artery syndrome: A case report. ( 26998097 )
2016
43
Superior Mesenteric Artery Syndrome: A Case Report of Two Surgical Options, Duodenal Derotation and Duodenojejunostomy. ( 28101395 )
2016
44
Conservative therapy for superior mesenteric artery syndrome. ( 26620963 )
2016
45
A Rare Case of Gastric Mantle Cell Lymphoma causing Superior Mesenteric Artery Syndrome in an Adult. ( 28031660 )
2016
46
Familial superior mesenteric artery syndrome. ( 27126095 )
2016
47
Laparoscopic Duodenojejunostomy for Superior Mesenteric Artery Syndrome. ( 27457852 )
2016
48
Superior mesenteric artery syndrome as a cause of acute pancreatitis. ( 27646321 )
2016
49
Superior mesenteric artery syndrome: CT findings. ( 27353179 )
2016
50
Acute abdominal pain caused by superior mesenteric artery syndrome in a healthy young boy. ( 27993824 )
2016

Variations for Superior Mesenteric Artery Syndrome

Expression for Superior Mesenteric Artery Syndrome

Search GEO for disease gene expression data for Superior Mesenteric Artery Syndrome.

Pathways for Superior Mesenteric Artery Syndrome

GO Terms for Superior Mesenteric Artery Syndrome

Cellular components related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC2 MUC5AC MUC6

Biological processes related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.58 MUC2 MUC5AC MUC6
2 ATP hydrolysis coupled proton transport GO:0015991 9.43 ATP12A ATP4A
3 cellular sodium ion homeostasis GO:0006883 9.37 ATP12A ATP4A
4 cellular potassium ion homeostasis GO:0030007 9.32 ATP12A ATP4A
5 sodium ion export across plasma membrane GO:0036376 9.26 ATP12A ATP4A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
7 maintenance of gastrointestinal epithelium GO:0030277 8.96 MUC2 MUC6
8 O-glycan processing GO:0016266 8.8 MUC2 MUC5AC MUC6

Molecular functions related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Superior Mesenteric Artery Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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