MCID: SPR007
MIFTS: 36

Superior Mesenteric Artery Syndrome

Categories: Cardiovascular diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Superior Mesenteric Artery Syndrome

MalaCards integrated aliases for Superior Mesenteric Artery Syndrome:

Name: Superior Mesenteric Artery Syndrome 12 73 20 44 15 17 70
Arteriomesenteric Compression of Duodenojejunal Flexure 70
Arteriomesenteric Duodenal Compression Syndrome 20
Vascular Compression of the Duodenum 20
Wilkie Syndrome 20
Cast Syndrome 20

Classifications:



External Ids:

Disease Ontology 12 DOID:3557
MeSH 44 D013478
NCIt 50 C85175
SNOMED-CT 67 24988007
UMLS 70 C0038828 C0400845

Summaries for Superior Mesenteric Artery Syndrome

GARD : 20 Superior mesenteric artery syndrome (SMAS) is a digestive condition that occurs when the duodenum (the first part of the small intestine) is compressed between two arteries (the aorta and the superior mesenteric artery). This compression causes partial or complete blockage of the duodenum. Symptoms vary based on severity, but can be severely debilitating. Symptoms may include abdominal pain, fullness, nausea, vomiting, and/or weight loss. SMAS typically is due to loss of the mesenteric fat pad (fatty tissue that surrounds the superior mesenteric artery). The most common cause is significant weight loss caused by medical disorders, psychological disorders, or surgery. In younger patients, it most commonly occurs after corrective spinal surgery for scoliosis. Delays in diagnosis may result in significant complications. Depending on the cause and severity, treatment options may include addressing the underlying cause, dietary changes (small feedings or a liquid diet), and/or surgery. Symptoms may not resolve completely after treatment.

MalaCards based summary : Superior Mesenteric Artery Syndrome, also known as arteriomesenteric compression of duodenojejunal flexure, is related to duodenal obstruction and intestinal obstruction, and has symptoms including abdominal angina An important gene associated with Superior Mesenteric Artery Syndrome is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Proton Pump Inhibitor Pathway, Pharmacodynamics and Secretion of Hydrochloric Acid in Parietal Cells. Affiliated tissues include small intestine, bone and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 Superior mesenteric artery (SMA) syndrome is a gastro-vascular disorder in which the third and final... more...

Related Diseases for Superior Mesenteric Artery Syndrome

Diseases related to Superior Mesenteric Artery Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 319)
# Related Disease Score Top Affiliating Genes
1 duodenal obstruction 31.3 CRP ATP4A ATP12A
2 intestinal obstruction 31.2 CRP ATP4A ATP12A
3 gastric dilatation 30.9 CRP ATP4A ATP12A
4 peptic ulcer disease 30.6 HRH2 ATP4A ATP12A
5 gastroparesis 30.6 MLNR HRH2
6 gastroesophageal reflux 30.3 HRH2 ATP4A ATP12A
7 bile reflux 30.3 ATP4A ATP12A
8 celiac disease 1 30.2 CRP ATP4A ATP12A
9 meckel diverticulum 30.2 CRP ATP4A
10 intestinal perforation 30.2 CRP ATP4A ATP12A
11 aspiration pneumonia 30.2 CRP ATP4A ATP12A
12 constipation 30.0 MLNR CRP ATP4A ATP12A
13 duodenitis 30.0 CRP ATP4A ATP12A
14 peptic esophagitis 30.0 HRH2 ATP4A ATP12A
15 biliary dyskinesia 29.9 ATP4A ATP12A
16 volvulus of midgut 29.8 MLNR CRP ATP4A ATP12A
17 hernia, hiatus 29.8 HRH2 CRP ATP4A ATP12A
18 gastroenteritis 29.7 HRH2 CRP
19 paralytic ileus 29.5 CRP AVP ATP4A ATP12A
20 renal nutcracker syndrome 11.3
21 scoliosis 10.8
22 anorexia nervosa 10.7
23 aortic aneurysm 10.6
24 aortic aneurysm, familial abdominal, 1 10.6
25 eating disorder 10.5
26 idiopathic scoliosis 10.4
27 ileus 10.4
28 aneurysm 10.4
29 pancreatitis 10.4
30 scoliosis, isolated 1 10.4
31 duodenal ulcer 10.4
32 acute pancreatitis 10.4
33 purpura 10.4
34 paraplegia 10.4
35 quadriplegia 10.3
36 amyotrophic lateral sclerosis 1 10.3
37 body mass index quantitative trait locus 1 10.3
38 intestinal pseudo-obstruction 10.3
39 cerebral palsy 10.3
40 lateral sclerosis 10.3
41 sensory peripheral neuropathy 10.3
42 gastritis 10.3
43 hyperthyroidism 10.3
44 spinal cord injury 10.3
45 cholangitis 10.2
46 vagus nerve disease 10.2 ATP4A ATP12A
47 scalp dermatosis 10.2 ATP4A ATP12A
48 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A
49 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
50 lingual goiter 10.2 ATP4A ATP12A

Graphical network of the top 20 diseases related to Superior Mesenteric Artery Syndrome:



Diseases related to Superior Mesenteric Artery Syndrome

Symptoms & Phenotypes for Superior Mesenteric Artery Syndrome

UMLS symptoms related to Superior Mesenteric Artery Syndrome:


abdominal angina

GenomeRNAi Phenotypes related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.66 KRT17
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.66 KRT17
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.66 CRP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.66 CRP
5 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.66 CRP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.66 CRP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.66 KRT17
8 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.66 KRT17
9 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.66 KRT17
10 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.66 KRT17
11 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.66 KRT17
12 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.66 HRH2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.66 KRT17
14 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.66 HRH2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.66 KRT17
16 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.66 KRT17
17 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.66 KRT17
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.66 KRT17
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.66 HRH2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-55 9.66 HRH2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.66 CRP HRH2

Drugs & Therapeutics for Superior Mesenteric Artery Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Superior Mesenteric Artery Syndrome: a Prospective Study in a Single Institution Completed NCT03416647
2 A Prospective, Observational, Multicenter Study on Ultrasound Evaluation of Superior Mesenteric Artery Measurements in a Healthy Pediatric Population Recruiting NCT04515251

Search NIH Clinical Center for Superior Mesenteric Artery Syndrome

Cochrane evidence based reviews: superior mesenteric artery syndrome

Genetic Tests for Superior Mesenteric Artery Syndrome

Anatomical Context for Superior Mesenteric Artery Syndrome

MalaCards organs/tissues related to Superior Mesenteric Artery Syndrome:

40
Small Intestine, Bone, Spinal Cord, Colon, Pancreas, Eye, Brain

Publications for Superior Mesenteric Artery Syndrome

Articles related to Superior Mesenteric Artery Syndrome:

(show top 50) (show all 685)
# Title Authors PMID Year
1
A Case Series of Laparoscopic Duodenojejunostomy for the Treatment of Pediatric Superior Mesenteric Artery Syndrome. 61 20
27747293 2016
2
A Traumatic Quinceañera: Acute Superior Mesenteric Artery Syndrome in an Adolescent Girl. 61
30130339 2021
3
Correction to: Laparoscopic Duodenojejunostomy for Superior Mesenteric Artery Syndrome. 61
33537922 2021
4
POCUS Case Review: Considering Superior Mesenteric Artery Syndrome in the Pediatric Emergency Department. 61
32541404 2021
5
Superior mesenteric artery syndrome secondary to an abdominal aortic aneurysm. 61
33725497 2021
6
A rare instance of Wilkie's syndrome in a young male during the holy month of Ramadan. 61
33631645 2021
7
Chronic Hypercapnic Respiratory Failure in an Adult Patient with Silver-Russell Syndrome: A Case Report. 61
33518558 2021
8
Successful treatment of superior mesenteric artery syndrome by endoscopic ultrasound-guided gastrojejunostomy. 61
32559775 2021
9
Superior mesenteric artery syndrome in a patient with celiacomesenteric trunk. 61
33622741 2021
10
EUS-guided gastroenterostomy for duodenal obstruction secondary to superior mesenteric artery syndrome. 61
33490746 2021
11
A case of superior mesenteric artery syndrome got physicians in trouble. 61
33569168 2021
12
Unusual presentation of superior mesenteric artery syndrome after trauma. 61
33462027 2021
13
Superior mesenteric artery syndrome in a patient with rheumatoid arthritis and rheumatoid cachexia during the COVID-19 pandemic. 61
33428099 2021
14
Gastrointestinal: Abdominal aortic aneurysm caused symptoms mimicking superior mesenteric artery syndrome. 61
32627232 2021
15
Aortomesenteric clamp: association with Wilkie syndorme and nutcracker syndrome. 61
33406845 2021
16
Laparoscopic duodenojejunostomy to manage small bowel obstruction due to superior mesenteric artery syndrome after Roux-en-Y gastric bypass. 61
33172702 2021
17
Duodenoduodenostomy in the Treatment of Superior Mesenteric Artery Syndrome. 61
33342302 2020
18
Abdominal aortic aneurysm and its association with duodenal obstruction: aortoduodenal syndrome. 61
33299591 2020
19
A case of gastric ischemia caused by massive gastric dilatation due to superior mesenteric artery syndrome. 61
32720221 2020
20
Post-Operative Superior Mesenteric Artery Syndrome Following Retroperitoneal Sarcoma Resection. 61
33599214 2020
21
Superior Mesenteric Artery Syndrome: An Unusual Cause of Abdominal Pain. 61
33354450 2020
22
An extensive posterior circulation infarction secondary to primary hyperthyroidism accompanied with superior mesenteric artery syndrome: A case report and description of patho-physiological association. 61
33181647 2020
23
The risks, reasons, and costs for 30- and 90-day readmissions after fusion surgery for adolescent idiopathic scoliosis. 61
33157526 2020
24
Clinical and Radiological Outcomes of Less Invasive Temporary Internal Distraction Followed by Staged Pedicle Screw Instrumentation in Adolescents with Severe Idiopathic Scoliosis at 2-Year Minimum Follow-Up. 61
32750520 2020
25
Superior mesenteric artery syndrome. 61
33235782 2020
26
Co-occurrence of compression syndromes: celiac axis stenosis, superior mesenteric artery and nutcracker syndrome. 61
32755144 2020
27
Complete laparoscopic duodenojejunostomy for superior mesenteric artery syndrome: Linear stapled closure of the common enterotomy. 61
31845494 2020
28
Ligament of Treitz Release With Duodenal Lowering for Pediatric Superior Mesenteric Artery Syndrome. 61
32422431 2020
29
Superior mesenteric artery syndrome complicating the clinical presentation and treatment of inflammatory bowel disease in a pediatric patient. 61
33107276 2020
30
Wilkie's Weight Loss Wonder, A Case Series. 61
33655184 2020
31
Spinal Casting for the Treatment of Severe Early Onset Scoliosis: Utilization of a Nonsurgical Health Care Provider for Cast Application. 61
32701660 2020
32
Perioperative outcome of severe rigid idiopathic scoliosis: Single-staged posterior spinal fusion utilizing a dual attending surgeon strategy. A report of 41 patients. 61
32762498 2020
33
Case report of superior mesenteric artery syndrome that developed in a lean type 2 diabetes patient and was associated with rapid body weight loss after sodium-glucose cotransporter 2 inhibitor administration. 61
32020751 2020
34
Superior mesenteric artery syndrome: A rare complication of scoliosis corrective surgery. 61
32909907 2020
35
Superior Mesenteric Artery Syndrome: A Forgotten Cause of Duodenal Obstruction. 61
33133874 2020
36
Wilkie's Syndrome as a Rare Cause of Duodenal Obstruction: Perspicacity Is in the Radiological Details. 61
33083170 2020
37
Combined Superior Mesenteric Artery Syndrome and Nutcracker Syndrome in a Young Patient: A Case Report and Review of the Literature. 61
32772039 2020
38
Predictors of Superior Mesenteric Artery Syndrome: Evidence from a Case-Control Study. 61
32821627 2020
39
Superior Mesenteric Artery Syndrome Aggravating Severe Malnutrition. 61
32026334 2020
40
Clinical Usefulness of Gastric-emptying Scintigraphy in Superior Mesenteric Artery Syndrome: A Case Report. 61
32227314 2020
41
Superior Mesenteric Artery Syndrome: A Classic Presentation of a Rare Entity. 61
32983690 2020
42
[Wilkie's syndrome caused by exogenous hyperthyroidism in a patient with primary autoimmune hypothyroidism: a case report and literature review]. 61
33181816 2020
43
Minimal weight loss related to a short fasting period causes superior mesenteric artery syndrome in a patient with amyotrophic lateral sclerosis: A case report. 61
32629635 2020
44
Minimally Invasive Surgical Approach for the Treatment of Superior Mesenteric Artery Syndrome: Long-Term Outcomes. 61
32030438 2020
45
Superior mesenteric artery syndrome and nutcracker syndrome. 61
31902598 2020
46
False Elevation of Volume Determined by Bladder Scanner Secondary to Bowel Obstruction. 61
32426660 2020
47
Endoscopic Ultrasound-Guided Gastrojejunostomy for the Management of Superior Mesenteric Artery Syndrome. 61
32167937 2020
48
Chronic vomiting in children: A prospective study reveals rumination syndrome is an important etiology that is underdiagnosed and untreated. 61
32436177 2020
49
A Case of Nutcracker Syndrome Combined with Wilkie Syndrome with Unusual Clinical Presentation. 61
32317620 2020
50
Adolescent with Superior Mesenteric Artery Syndrome. 61
33082917 2020

Variations for Superior Mesenteric Artery Syndrome

Expression for Superior Mesenteric Artery Syndrome

Search GEO for disease gene expression data for Superior Mesenteric Artery Syndrome.

Pathways for Superior Mesenteric Artery Syndrome

Pathways related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.61 HRH2 ATP4A
2 9.32 HRH2 ATP4A

GO Terms for Superior Mesenteric Artery Syndrome

Biological processes related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell growth GO:0030307 9.43 KRT17 AVP
2 potassium ion import across plasma membrane GO:1990573 9.4 ATP4A ATP12A
3 positive regulation of vasoconstriction GO:0045907 9.37 HRH2 AVP
4 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
5 vasoconstriction GO:0042310 9.26 CRP AVP
6 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
7 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
8 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Superior Mesenteric Artery Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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