MCID: SPN031
MIFTS: 33

Supine Hypotensive Syndrome

Categories: Cardiovascular diseases

Aliases & Classifications for Supine Hypotensive Syndrome

MalaCards integrated aliases for Supine Hypotensive Syndrome:

Name: Supine Hypotensive Syndrome 12 15
Maternal Hypotension Syndrome 71 32
Maternal Hypotension Syndrome, Antepartum Condition or Complication 71
Maternal Hypotension Syndrome, Postpartum Condition or Complication 71
Antepartum Maternal Hypotension Syndrome 12
Postpartum Maternal Hypotension Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10556
ICD9CM 34 669.20
ICD10 32 O26.5
UMLS 71 C0157456 C0157459 C0157460 more

Summaries for Supine Hypotensive Syndrome

Disease Ontology : 12 A vascular disease that is characterized by severe supine hypotension in late pregnancy, whose clinical presentation ranges from minimal cardiovascular alterations to severe shock, resulting from inferior vena cava compression by gravid uterus.

MalaCards based summary : Supine Hypotensive Syndrome, also known as maternal hypotension syndrome, is related to cardiac arrest and testicular trophoblastic tumor. An important gene associated with Supine Hypotensive Syndrome is RPL34 (Ribosomal Protein L34). The drugs Morphine and Atropine have been mentioned in the context of this disorder. Affiliated tissues include uterus, placenta and testes, and related phenotype is normal.

Related Diseases for Supine Hypotensive Syndrome

Diseases related to Supine Hypotensive Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 cardiac arrest 29.5 REN OXT AVP
2 testicular trophoblastic tumor 10.3 CSH2 CSH1
3 gestational ovarian choriocarcinoma 10.3 CSH2 CSH1
4 choriocarcinoma of the testis 10.3 CSH2 CSH1
5 non-gestational ovarian choriocarcinoma 10.3 CSH2 CSH1
6 rh isoimmunization 10.3 CSH2 CSH1
7 corpus luteum cyst 10.3 CSH2 CSH1
8 non-gestational choriocarcinoma 10.3 CSH2 CSH1
9 femoral neuropathy 10.3 RPL34 F2
10 gestational choriocarcinoma 10.3 CSH2 CSH1
11 epithelioid trophoblastic tumor 10.3 CSH2 CSH1
12 lemierre's syndrome 10.3 F2 ACR
13 choriocarcinoma of ovary 10.2 CSH2 CSH1
14 intracranial hypotension 10.2 RPL34 F2
15 pyeloureteritis cystica 10.2 REN ALYREF
16 infantile liver failure syndrome 1 10.2 LARS1 F2
17 butyrylcholinesterase deficiency 10.2 CASK BCHE
18 cockayne syndrome b 10.2 CSH2 CSH1
19 placental abruption 10.2
20 placental site trophoblastic tumor 10.2 CSH2 CSH1
21 trophoblastic neoplasm 10.2 CSH2 CSH1
22 alexia 10.2 LINC-PINT BCHE
23 cholesterol embolism 10.1 REN F2
24 hypertensive encephalopathy 10.1 REN F2
25 persistent fetal circulation syndrome 10.1 OXT CSH2 CSH1
26 central sleep apnea 10.1 REN ALYREF
27 subleukemic leukemia 10.1 OXT AVP
28 benign essential hypertension 10.0 REN AVP
29 cardiac tamponade 10.0 REN F2
30 paralytic ileus 10.0 F2 AVP
31 malignant essential hypertension 10.0 SAMHD1 REN
32 schizophrenia 14 10.0 MAPK14 ACR
33 lumbosacral lipoma 10.0 RPL34 MAPK14
34 analbuminemia 10.0 F2 AVP
35 major depressive disorder 10.0
36 cyanosis, transient neonatal 10.0
37 mental depression 10.0
38 cystadenoma 10.0
39 ovarian cyst 10.0
40 depression 10.0
41 syncope 10.0
42 eclampsia 9.9 REN OXT F2
43 pulmonary edema 9.9 REN OXT F2
44 gestational trophoblastic neoplasm 9.9 CSH2 CSH1
45 alcoholic cardiomyopathy 9.9 REN AVP
46 inhibited male orgasm 9.9 OXT MAPK14
47 anuria 9.9 REN F2
48 inappropriate adh syndrome 9.9 REN OXT AVP
49 diabetes insipidus, nephrogenic, autosomal 9.9 REN OXT AVP
50 diabetes insipidus 9.9 REN OXT AVP

Graphical network of the top 20 diseases related to Supine Hypotensive Syndrome:



Diseases related to Supine Hypotensive Syndrome

Symptoms & Phenotypes for Supine Hypotensive Syndrome

MGI Mouse Phenotypes related to Supine Hypotensive Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.17 ACR AVP CD2 F2 MAPK14 REN

Drugs & Therapeutics for Supine Hypotensive Syndrome

Drugs for Supine Hypotensive Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4 57-27-2 5288826
2
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
3
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
4
Pseudoephedrine Approved Phase 4 90-82-4 7028
5
Norepinephrine Approved Phase 4 51-41-2 439260
6
Ephedrine Approved Phase 4 299-42-3 9294
7 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
8 Anesthetics, Local Phase 4
9 Narcotics Phase 4
10 Anti-Arrhythmia Agents Phase 4
11 Anti-Asthmatic Agents Phase 4
12 Pharmaceutical Solutions Phase 4
13 Analgesics, Opioid Phase 4
14 Adjuvants, Anesthesia Phase 4
15 Nasal Decongestants Phase 4
16 Respiratory System Agents Phase 4
17 Muscarinic Antagonists Phase 4
18 Cholinergic Agents Phase 4
19 Mydriatics Phase 4
20 Bronchodilator Agents Phase 4
21 Analgesics Phase 4
22 Parasympatholytics Phase 4
23 Cholinergic Antagonists Phase 4
24 Neurotransmitter Agents Phase 4
25 Sympathomimetics Phase 4
26 Anesthetics Phase 4
27 Adrenergic Agonists Phase 4
28 Central Nervous System Stimulants Phase 4
29 Vasoconstrictor Agents Phase 4
30 Central Nervous System Depressants Phase 4
31 Autonomic Agents Phase 4
32 Adrenergic Agents Phase 4
33
Ropivacaine Approved 84057-95-4 71273 175805

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pharmacological or Non-Pharmacological Management of Maternal Hypotension During Elective Cesarean Section Under Subarachnoid Anesthesia: a Randomized, Controlled Trial Completed NCT00991627 Phase 4 Bupivacaine;Morphine;Lactated Ringer's solution;Ephedrine, continuous infusion;Ephedrine, bolus;Atropine
2 Norepinephrine Versus Ephedrin for Prevention of Post Spinal Anesthesia in Cesarean Section Not yet recruiting NCT03719625 Phase 4 Ephedrine;Norepinephrine
3 Minimum Effective Dose of Intrathecal Ropivacaine Required for Cesarean Delivery: A Prospective, Randomized Comparison Between L2-3 and L3-4 Approach Completed NCT02565303 Ropivacaine
4 Ultrasound Evaluation of Inferior Vena Cava Compression During Elective Cesarean Delivery. Comparison of Tilt Versus No Tilt Positioning. Recruiting NCT03410199

Search NIH Clinical Center for Supine Hypotensive Syndrome

Genetic Tests for Supine Hypotensive Syndrome

Anatomical Context for Supine Hypotensive Syndrome

MalaCards organs/tissues related to Supine Hypotensive Syndrome:

40
Uterus, Placenta, Testes, Liver, Ovary, Testis

Publications for Supine Hypotensive Syndrome

Articles related to Supine Hypotensive Syndrome:

(show top 50) (show all 68)
# Title Authors PMID Year
1
Hemodynamic changes in women with symptoms of supine hypotensive syndrome. 61
31856296 2019
2
Aortocaval compression resulting in sudden loss of consciousness and severe bradycardia and hypotension during cesarean section in a patient with subvalvular aortic stenosis. 61
31272377 2019
3
A huge ovarian mucinous cystadenoma causing virilization, preterm labor, and persistent supine hypotensive syndrome during pregnancy. 61
27547742 2016
4
[Anesthetic Induction in a Patient with Giant Ovarian Tumor Who Developed Severe Hemodynamic Instability]. 61
26442415 2015
5
Prevention of supine hypotensive syndrome in pregnant women treated with transcranial magnetic stimulation. 61
24768354 2014
6
Sleep-disordered breathing in pregnancy: a review of the physiology and potential role for positional therapy. 61
23591835 2014
7
Anesthetic management of a patient with a giant ovarian tumor containing 83 l of fluid. 61
24102044 2013
8
Supine hypotensive syndrome as the probable cause of both maternal and fetal death. 61
22537582 2012
9
Pentax-AWS airway Scope as an alternative for awake flexible fiberoptic intubation of a morbidly obese patient in the semi-sitting position. 61
19234847 2009
10
Should we take a different angle in managing pregnant women at delivery? Attempting to avoid the 'supine hypotensive syndrome'. 61
19115642 2008
11
[Aortocaval compression syndrome]. 61
14992095 2003
12
[Thoracic epidural pressure and peripheral venous pressure in the lower extremity during supine hypotensive syndrome]. 61
12795129 2003
13
Influence of maternal position during epidural labor analgesia. 61
15321496 2003
14
Hemodynamic changes and baroreflex gain in the supine hypotensive syndrome. 61
12501076 2002
15
Laparoscopic surgery during pregnancy. 61
11244920 2001
16
Semi-Fowler's positioning, lateral tilts, and their effects on nonstress tests. 61
9313185 1997
17
Maternal position during labor: effects on fetal oxygen saturation measured by pulse oximetry. 61
8885916 1996
18
The supine hypotensive syndrome. 1960. 61
8678255 1995
19
[An unusual supine hypotensive syndrome during cesarean section: the importance of trying right tilt if there is a poor response to left tilt]. 61
7815712 1994
20
Supine hypotensive syndrome. 61
8164943 1994
21
[Cardiac arrests probably induced by hypermagnesemia during anesthesia for caesarean section]. 61
8182885 1994
22
Maternal cerebral hemodynamics in the supine hypotensive syndrome. 61
1727580 1992
23
[Replies to 8 questions asked about dental caring during pregnancy and nursing]. 61
1947586 1991
24
Cutaneous surgery and the pregnant patient. 61
2212124 1990
25
Uterine and umbilical flow velocity waveforms in the supine hypotensive syndrome. 61
2371021 1990
26
Oxygen saturation in the supine hypotensive syndrome. 61
3368171 1988
27
Factors influencing aortocaval compression in late pregnancy. 61
6702946 1984
28
Bicornuate uterus and aortocaval compression. 61
6846766 1983
29
[The echocardiographic observation of the cardiac function in normal pregnancy and supine hypotensive syndrome]. 61
7183051 1982
30
Death from a snake bite: associated with the supine hypotensive syndrome of pregnancy. 61
7132877 1982
31
'Postmortem' cesarean section with recovery of both mother and offspring. 61
7097967 1982
32
Supine hypotensive syndrome caused by intra-abdominal mass: a case report. 61
1033713 1976
33
Role of the anaesthetist in the prevention of maternal deaths in Caesarian Section. 61
16295078 1976
34
[Changes of vein pressure and renal function by different positions of pregnant women. (A contribution to the supine hypotensive syndrome) (author's transl)]. 61
4442681 1974
35
[Supine hypotensive syndrome and obstetric anaesthesia (author's transl)]. 61
4437570 1974
36
[10 cases with a supine hypotensive syndrome (author's transl)]. 61
4411550 1974
37
[Supine hypotensive syndrome in pregnancy]. 61
4485053 1972
38
[Case of unusual form of collapse occurring during labor (supine hypotensive syndrome)]. 61
5577769 1971
39
[Obstetric shock due to the supine hypotensive syndrome]. 61
5093393 1971
40
[Supine hypotensive syndrome]. 61
5732680 1968
41
[The vena-cava-inferior-syndrome (supine-hypotensive syndrome) in the late pregnancy]. 61
5696608 1968
42
[Collapse in a pregnant woman in supine position (supine hypotensive syndrome) as a possible cause of fetal death]. 61
5699703 1968
43
[Studies of the duration of the placental stage in various positions of the women. (Simultaneously a contribution on the problems of the supine hypotensive syndrome)]. 61
5595030 1967
44
[Shock due to supine hypotensive syndrome]. 61
6071959 1967
45
Giant ovarian cyst and the supine hypotensive syndrome. 61
5946532 1966
46
SUPINE HYPOTENSIVE SYNDROME, SPINAL ANESTHESIA, AND APPARENT CARDIAC ARREST. A CASE REPORT. 61
14084156 1963
47
[Case of supine hypotensive syndrome]. 61
14031476 1963
48
Supine Hypotensive Syndrome. 61
20327415 1963
49
Supine Hypotensive Syndrome. 61
20327416 1963
50
The supine hypotensive syndrome. 61
14023689 1962

Variations for Supine Hypotensive Syndrome

Expression for Supine Hypotensive Syndrome

Search GEO for disease gene expression data for Supine Hypotensive Syndrome.

Pathways for Supine Hypotensive Syndrome

GO Terms for Supine Hypotensive Syndrome

Cellular components related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 REN OXT F2 CSH2 CSH1 BCHE
2 vesicle GO:0031982 9.33 CSH2 CSH1 CASK
3 extracellular region GO:0005576 9.32 REN OXT MAPK14 F2 CSH2 CSH1

Biological processes related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of reactive oxygen species metabolic process GO:2000379 9.48 MAPK14 F2
2 animal organ development GO:0048513 9.46 CSH2 CSH1
3 grooming behavior GO:0007625 9.43 OXT AVP
4 growth hormone receptor signaling pathway GO:0060396 9.4 CSH2 CSH1
5 positive regulation of growth GO:0045927 9.37 CSH2 CSH1
6 maternal behavior GO:0042711 9.32 OXT AVP
7 drinking behavior GO:0042756 9.26 REN OXT
8 hyperosmotic salinity response GO:0042538 9.16 OXT AVP
9 maternal aggressive behavior GO:0002125 8.96 OXT AVP
10 positive regulation of JAK-STAT cascade GO:0046427 8.8 F2 CSH2 CSH1

Molecular functions related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.56 REN F2 CD2 AVP
2 growth factor activity GO:0008083 9.5 F2 CSH2 CSH1
3 neuropeptide hormone activity GO:0005184 9.37 OXT AVP
4 growth hormone receptor binding GO:0005131 9.16 CSH2 CSH1
5 neurohypophyseal hormone activity GO:0005185 8.96 OXT AVP
6 hormone activity GO:0005179 8.92 OXT CSH2 CSH1 AVP

Sources for Supine Hypotensive Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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