MCID: SPN031
MIFTS: 25

Supine Hypotensive Syndrome

Categories: Cardiovascular diseases

Aliases & Classifications for Supine Hypotensive Syndrome

MalaCards integrated aliases for Supine Hypotensive Syndrome:

Name: Supine Hypotensive Syndrome 12 15
Maternal Hypotension Syndrome, Antepartum Condition or Complication 74
Maternal Hypotension Syndrome, Postpartum Condition or Complication 74
Antepartum Maternal Hypotension Syndrome 12
Postpartum Maternal Hypotension Syndrome 12
Maternal Hypotension Syndrome 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10556
ICD9CM 36 669.20
ICD10 34 O26.5

Summaries for Supine Hypotensive Syndrome

Disease Ontology : 12 A vascular disease that is characterized by severe supine hypotension in late pregnancy, whose clinical presentation ranges from minimal cardiovascular alterations to severe shock, resulting from inferior vena cava compression by gravid uterus.

MalaCards based summary : Supine Hypotensive Syndrome, also known as maternal hypotension syndrome, antepartum condition or complication, is related to placental abruption and cardiac arrest. An important gene associated with Supine Hypotensive Syndrome is JAG1 (Jagged Canonical Notch Ligand 1). The drugs Norepinephrine and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include uterus and placenta, and related phenotype is Negative genetic interaction between MUS81-/- and MUS81+/+.

Related Diseases for Supine Hypotensive Syndrome

Diseases related to Supine Hypotensive Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 placental abruption 10.2
2 cardiac arrest 10.0
3 cystadenoma 10.0
4 ovarian cyst 10.0

Symptoms & Phenotypes for Supine Hypotensive Syndrome

GenomeRNAi Phenotypes related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between MUS81-/- and MUS81+/+ GR00255-A-2 8.62 CD2 RPL34

Drugs & Therapeutics for Supine Hypotensive Syndrome

Drugs for Supine Hypotensive Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4 51-41-2 439260
2
Ephedrine Approved Phase 4 299-42-3 9294
3
Pseudoephedrine Approved Phase 4 90-82-4 7028
4 Adrenergic alpha-Agonists Phase 4
5 Adrenergic Agents Phase 4
6 Adrenergic Agonists Phase 4
7 Peripheral Nervous System Agents Phase 4
8 Central Nervous System Depressants Phase 4
9 Anesthetics Phase 4
10 Central Nervous System Stimulants Phase 4
11 Autonomic Agents Phase 4
12 Vasoconstrictor Agents Phase 4
13 Neurotransmitter Agents Phase 4
14 Sympathomimetics Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Norepinephrine Versus Ephedrin for Prevention of Post Spinal Anesthesia in Cesarean Section Not yet recruiting NCT03719625 Phase 4 Ephedrine;Norepinephrine

Search NIH Clinical Center for Supine Hypotensive Syndrome

Genetic Tests for Supine Hypotensive Syndrome

Anatomical Context for Supine Hypotensive Syndrome

MalaCards organs/tissues related to Supine Hypotensive Syndrome:

42
Uterus, Placenta

Publications for Supine Hypotensive Syndrome

Articles related to Supine Hypotensive Syndrome:

(show all 29)
# Title Authors Year
1
A huge ovarian mucinous cystadenoma causing virilization, preterm labor, and persistent supine hypotensive syndrome during pregnancy. ( 27547742 )
2016
2
Prevention of supine hypotensive syndrome in pregnant women treated with transcranial magnetic stimulation. ( 24768354 )
2014
3
Supine hypotensive syndrome as the probable cause of both maternal and fetal death. ( 22537582 )
2012
4
Hemodynamic changes and baroreflex gain in the supine hypotensive syndrome. ( 12501076 )
2002
5
The supine hypotensive syndrome. 1960. ( 8678255 )
1995
6
Supine hypotensive syndrome. ( 8164943 )
1994
7
Maternal cerebral hemodynamics in the supine hypotensive syndrome. ( 1727580 )
1992
8
Uterine and umbilical flow velocity waveforms in the supine hypotensive syndrome. ( 2371021 )
1990
9
Oxygen saturation in the supine hypotensive syndrome. ( 3368171 )
1988
10
Death from a snake bite: associated with the supine hypotensive syndrome of pregnancy. ( 7132877 )
1982
11
Supine hypotensive syndrome caused by intra-abdominal mass: a case report. ( 1033713 )
1976
12
Giant ovarian cyst and the supine hypotensive syndrome. ( 5946532 )
1966
13
SUPINE HYPOTENSIVE SYNDROME, SPINAL ANESTHESIA, AND APPARENT CARDIAC ARREST. A CASE REPORT. ( 14084156 )
1963
14
Supine Hypotensive Syndrome. ( 20327415 )
1963
15
Supine Hypotensive Syndrome. ( 20327416 )
1963
16
Postural hypotension in late pregnancy. "The supine hypotensive syndrome". ( 14008465 )
1962
17
The supine hypotensive syndrome. ( 14023689 )
1962
18
The supine hypotensive syndrome during conduction anaesthesia for the near-term gravid patient: case reports. ( 13708489 )
1961
19
Supine hypotensive syndrome and abruptio placentae. A case report. ( 13742064 )
1960
20
Supine hypotensive syndrome with ECG changes. Case report. ( 13804663 )
1960
21
Incidence of the supine hypotensive syndrome in late pregnancy. A clinical study in 500 subjects. ( 14402779 )
1960
22
The supine hypotensive syndrome. Its importance to the anaesthetist. ( 14402780 )
1960
23
Supine hypotensive syndrome of late pregnancy and premature separation of the placenta. ( 14435420 )
1960
24
Supine hypotensive syndrome in pregnancy; report of a case. ( 13566720 )
1958
25
The supine hypotensive syndrome; a factor in the etiology of abruptio placentae. ( 13590649 )
1958
26
Supine hypotensive syndrome; a case report. ( 13385898 )
1957
27
The supine hypotensive syndrome of pregnancy. ( 13358969 )
1956
28
Supine hypotensive syndrome producing abruptio placentae. ( 13233765 )
1954
29
Supine hypotensive syndrome in late pregnancy. ( 13055188 )
1953

Variations for Supine Hypotensive Syndrome

Expression for Supine Hypotensive Syndrome

Search GEO for disease gene expression data for Supine Hypotensive Syndrome.

Pathways for Supine Hypotensive Syndrome

GO Terms for Supine Hypotensive Syndrome

Sources for Supine Hypotensive Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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