MCID: SPN031
MIFTS: 25

Supine Hypotensive Syndrome

Categories: Cardiovascular diseases

Aliases & Classifications for Supine Hypotensive Syndrome

MalaCards integrated aliases for Supine Hypotensive Syndrome:

Name: Supine Hypotensive Syndrome 12 15
Maternal Hypotension Syndrome 72 33
Maternal Hypotension Syndrome, Antepartum Condition or Complication 72
Maternal Hypotension Syndrome, Postpartum Condition or Complication 72
Antepartum Maternal Hypotension Syndrome 12
Postpartum Maternal Hypotension Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10556
ICD9CM 35 669.20
ICD10 33 O26.5
UMLS 72 C0157456 C0157459 C0157460 more

Summaries for Supine Hypotensive Syndrome

Disease Ontology : 12 A vascular disease that is characterized by severe supine hypotension in late pregnancy, whose clinical presentation ranges from minimal cardiovascular alterations to severe shock, resulting from inferior vena cava compression by gravid uterus.

MalaCards based summary : Supine Hypotensive Syndrome, also known as maternal hypotension syndrome, is related to placental abruption and major depressive disorder. An important gene associated with Supine Hypotensive Syndrome is CD2 (CD2 Molecule). The drugs Morphine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include uterus, placenta and testes, and related phenotype is Negative genetic interaction between MUS81-/- and MUS81+/+.

Related Diseases for Supine Hypotensive Syndrome

Diseases related to Supine Hypotensive Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 placental abruption 10.2
2 major depressive disorder 10.0
3 cyanosis, transient neonatal 10.0
4 cardiac arrest 10.0
5 mental depression 10.0
6 cystadenoma 10.0
7 ovarian cyst 10.0
8 depression 10.0
9 syncope 10.0

Graphical network of the top 20 diseases related to Supine Hypotensive Syndrome:



Diseases related to Supine Hypotensive Syndrome

Symptoms & Phenotypes for Supine Hypotensive Syndrome

GenomeRNAi Phenotypes related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between MUS81-/- and MUS81+/+ GR00255-A-2 8.62 CD2 RPL34

Drugs & Therapeutics for Supine Hypotensive Syndrome

Drugs for Supine Hypotensive Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4 57-27-2 5288826
2
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
3
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
4
Norepinephrine Approved Phase 4 51-41-2 439260
5
Ephedrine Approved Phase 4 299-42-3 9294
6
Pseudoephedrine Approved Phase 4 90-82-4 7028
7 Anesthetics, Local Phase 4
8 Parasympatholytics Phase 4
9 Pharmaceutical Solutions Phase 4
10 Narcotics Phase 4
11 Nasal Decongestants Phase 4
12 Adjuvants, Anesthesia Phase 4
13 Cholinergic Agents Phase 4
14 Muscarinic Antagonists Phase 4
15 Analgesics Phase 4
16 Respiratory System Agents Phase 4
17 Mydriatics Phase 4
18 Analgesics, Opioid Phase 4
19 Cholinergic Antagonists Phase 4
20 Anti-Arrhythmia Agents Phase 4
21 Anti-Asthmatic Agents Phase 4
22 Bronchodilator Agents Phase 4
23 Sympathomimetics Phase 4
24 Central Nervous System Stimulants Phase 4
25 Adrenergic alpha-Agonists Phase 4
26 Adrenergic Agonists Phase 4
27 Peripheral Nervous System Agents Phase 4
28 Anesthetics Phase 4
29 Neurotransmitter Agents Phase 4
30 Central Nervous System Depressants Phase 4
31 Adrenergic Agents Phase 4
32 Vasoconstrictor Agents Phase 4
33 Autonomic Agents Phase 4
34
Ropivacaine Approved 84057-95-4 71273 175805
35 Kava Approved, Investigational, Nutraceutical 9000-38-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pharmacological or Non-Pharmacological Management of Maternal Hypotension During Elective Cesarean Section Under Subarachnoid Anesthesia: a Randomized, Controlled Trial Completed NCT00991627 Phase 4 Bupivacaine;Morphine;Lactated Ringer's solution;Ephedrine, continuous infusion;Ephedrine, bolus;Atropine
2 Norepinephrine Versus Ephedrin for Prevention of Post Spinal Anesthesia in Cesarean Section Not yet recruiting NCT03719625 Phase 4 Ephedrine;Norepinephrine
3 Minimum Effective Dose of Intrathecal Ropivacaine Required for Cesarean Delivery: A Prospective, Randomized Comparison Between L2-3 and L3-4 Approach Completed NCT02565303 Ropivacaine
4 Ultrasound Evaluation of Inferior Vena Cava Compression During Elective Cesarean Delivery. Comparison of Tilt Versus No Tilt Positioning. Recruiting NCT03410199

Search NIH Clinical Center for Supine Hypotensive Syndrome

Genetic Tests for Supine Hypotensive Syndrome

Anatomical Context for Supine Hypotensive Syndrome

MalaCards organs/tissues related to Supine Hypotensive Syndrome:

41
Uterus, Placenta, Testes

Publications for Supine Hypotensive Syndrome

Articles related to Supine Hypotensive Syndrome:

(show top 50) (show all 67)
# Title Authors PMID Year
1
Aortocaval compression resulting in sudden loss of consciousness and severe bradycardia and hypotension during cesarean section in a patient with subvalvular aortic stenosis. 38
31272377 2019
2
A huge ovarian mucinous cystadenoma causing virilization, preterm labor, and persistent supine hypotensive syndrome during pregnancy. 38
27547742 2016
3
[Anesthetic Induction in a Patient with Giant Ovarian Tumor Who Developed Severe Hemodynamic Instability]. 38
26442415 2015
4
Prevention of supine hypotensive syndrome in pregnant women treated with transcranial magnetic stimulation. 38
24768354 2014
5
Sleep-disordered breathing in pregnancy: a review of the physiology and potential role for positional therapy. 38
23591835 2014
6
Anesthetic management of a patient with a giant ovarian tumor containing 83 l of fluid. 38
24102044 2013
7
Supine hypotensive syndrome as the probable cause of both maternal and fetal death. 38
22537582 2012
8
Pentax-AWS airway Scope as an alternative for awake flexible fiberoptic intubation of a morbidly obese patient in the semi-sitting position. 38
19234847 2009
9
Should we take a different angle in managing pregnant women at delivery? Attempting to avoid the 'supine hypotensive syndrome'. 38
19115642 2008
10
[Aortocaval compression syndrome]. 38
14992095 2003
11
[Thoracic epidural pressure and peripheral venous pressure in the lower extremity during supine hypotensive syndrome]. 38
12795129 2003
12
Influence of maternal position during epidural labor analgesia. 38
15321496 2003
13
Hemodynamic changes and baroreflex gain in the supine hypotensive syndrome. 38
12501076 2002
14
Laparoscopic surgery during pregnancy. 38
11244920 2001
15
Semi-Fowler's positioning, lateral tilts, and their effects on nonstress tests. 38
9313185 1997
16
Maternal position during labor: effects on fetal oxygen saturation measured by pulse oximetry. 38
8885916 1996
17
The supine hypotensive syndrome. 1960. 38
8678255 1995
18
[An unusual supine hypotensive syndrome during cesarean section: the importance of trying right tilt if there is a poor response to left tilt]. 38
7815712 1994
19
Supine hypotensive syndrome. 38
8164943 1994
20
[Cardiac arrests probably induced by hypermagnesemia during anesthesia for caesarean section]. 38
8182885 1994
21
Maternal cerebral hemodynamics in the supine hypotensive syndrome. 38
1727580 1992
22
[Replies to 8 questions asked about dental caring during pregnancy and nursing]. 38
1947586 1991
23
Cutaneous surgery and the pregnant patient. 38
2212124 1990
24
Uterine and umbilical flow velocity waveforms in the supine hypotensive syndrome. 38
2371021 1990
25
Oxygen saturation in the supine hypotensive syndrome. 38
3368171 1988
26
Factors influencing aortocaval compression in late pregnancy. 38
6702946 1984
27
Bicornuate uterus and aortocaval compression. 38
6846766 1983
28
[The echocardiographic observation of the cardiac function in normal pregnancy and supine hypotensive syndrome]. 38
7183051 1982
29
Death from a snake bite: associated with the supine hypotensive syndrome of pregnancy. 38
7132877 1982
30
'Postmortem' cesarean section with recovery of both mother and offspring. 38
7097967 1982
31
Supine hypotensive syndrome caused by intra-abdominal mass: a case report. 38
1033713 1976
32
Role of the anaesthetist in the prevention of maternal deaths in Caesarian Section. 38
16295078 1976
33
[Changes of vein pressure and renal function by different positions of pregnant women. (A contribution to the supine hypotensive syndrome) (author's transl)]. 38
4442681 1974
34
[Supine hypotensive syndrome and obstetric anaesthesia (author's transl)]. 38
4437570 1974
35
[10 cases with a supine hypotensive syndrome (author's transl)]. 38
4411550 1974
36
[Supine hypotensive syndrome in pregnancy]. 38
4485053 1972
37
[Case of unusual form of collapse occurring during labor (supine hypotensive syndrome)]. 38
5577769 1971
38
[Obstetric shock due to the supine hypotensive syndrome]. 38
5093393 1971
39
[Supine hypotensive syndrome]. 38
5732680 1968
40
[The vena-cava-inferior-syndrome (supine-hypotensive syndrome) in the late pregnancy]. 38
5696608 1968
41
[Collapse in a pregnant woman in supine position (supine hypotensive syndrome) as a possible cause of fetal death]. 38
5699703 1968
42
[Studies of the duration of the placental stage in various positions of the women. (Simultaneously a contribution on the problems of the supine hypotensive syndrome)]. 38
5595030 1967
43
[Shock due to supine hypotensive syndrome]. 38
6071959 1967
44
Giant ovarian cyst and the supine hypotensive syndrome. 38
5946532 1966
45
SUPINE HYPOTENSIVE SYNDROME, SPINAL ANESTHESIA, AND APPARENT CARDIAC ARREST. A CASE REPORT. 38
14084156 1963
46
[Case of supine hypotensive syndrome]. 38
14031476 1963
47
Supine Hypotensive Syndrome. 38
20327415 1963
48
Supine Hypotensive Syndrome. 38
20327416 1963
49
The supine hypotensive syndrome. 38
14023689 1962
50
[A peculiar form of collapse in women in advanced pregnancy (supine hypotensive syndrome)]. 38
13932380 1962

Variations for Supine Hypotensive Syndrome

Expression for Supine Hypotensive Syndrome

Search GEO for disease gene expression data for Supine Hypotensive Syndrome.

Pathways for Supine Hypotensive Syndrome

GO Terms for Supine Hypotensive Syndrome

Sources for Supine Hypotensive Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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