Supine Hypotensive Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A vascular disease that is characterized by severe supine hypotension in late pregnancy, whose clinical presentation ranges from minimal cardiovascular alterations to severe shock, resulting from inferior vena cava compression by gravid uterus.

MalaCards based summary: Supine Hypotensive Syndrome, also known as maternal hypotension syndrome, is related to major depressive disorder and testicular trophoblastic tumor. An important gene associated with Supine Hypotensive Syndrome is LARS1 (Leucyl-TRNA Synthetase 1), and among its related pathways/superpathways are DREAM Repression and Dynorphin Expression and Keratinization. The drugs Racephedrine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include uterus and placenta, and related phenotypes are homeostasis/metabolism and growth/size/body region

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Related Diseases for Supine Hypotensive Syndrome

Diseases related to Supine Hypotensive Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)

#	Related Disease	Score	Top Affiliating Genes
1	major depressive disorder	28.7	OXT NR3C2 INS CRP AVP ALB
2	testicular trophoblastic tumor	10.4	CSH2 CSH1
3	non-gestational ovarian choriocarcinoma	10.4	CSH2 CSH1
4	gestational ovarian choriocarcinoma	10.4	CSH2 CSH1
5	choriocarcinoma of ovary	10.4	CSH2 CSH1
6	rh isoimmunization	10.4	CSH2 CSH1
7	fetishism	10.4	OXT LARS1
8	acquired hemangioma	10.4	OXT ACR
9	corpus luteum cyst	10.4	CSH2 CSH1
10	uterine inversion	10.3	OXT F2
11	non-gestational choriocarcinoma	10.3	CSH2 CSH1
12	placental abruption	10.3
13	iga pemphigus	10.3	DSP DSC2
14	arrhythmogenic right ventricular dysplasia, familial, 4	10.3	PKP2 DSG2 DSC2
15	epithelioid trophoblastic tumor	10.3	CSH2 CSH1
16	meckel's diverticulitis	10.3	LARS1 CRP
17	colonic lymphangioma	10.3	KRT20 ACR
18	urinary bladder small cell neuroendocrine carcinoma	10.3	KRT20 ACR
19	arrhythmogenic right ventricular dysplasia, familial, 10	10.3	PKP2 DSG2 DSC2
20	gestational trophoblastic neoplasm	10.3	OXT CSH2 CSH1
21	familial isolated arrhythmogenic right ventricular dysplasia	10.3	PKP2 DSP DSC2
22	protein-deficiency anemia	10.3	INS F2
23	ectopic pregnancy	10.2	OXT CSH2 CSH1
24	pyeloureteritis cystica	10.2	REN CRP
25	orbital osteomyelitis	10.2	F2 CRP
26	spontaneous tension pneumothorax	10.2	OXT CRP
27	nutmeg liver	10.2	ALB ACR
28	achenbach syndrome	10.2	F2 CRP
29	factitious disorder	10.2	INS F2
30	synovial angioma	10.2	F2 CRP
31	bullous skin disease	10.2	DSP DSG2 DSC2
32	emphysematous cholecystitis	10.2	F2 CRP
33	femoral neuropathy	10.2	F2 CRP
34	blue toe syndrome	10.2	F2 CRP
35	ureteric orifice cancer	10.2	INS F2
36	breast abscess	10.2	OXT CRP
37	renal pelvis squamous cell carcinoma	10.2	F2 CRP
38	subclavian steal syndrome	10.2	F2 CRP
39	hematocele of tunica vaginalis testis	10.2	F2 CRP
40	median arcuate ligament syndrome	10.2	TCF21 CRP
41	libman-sacks endocarditis	10.2	F2 CRP
42	nonbacterial thrombotic endocarditis	10.2	F2 CRP
43	orthostatic proteinuria	10.2	REN ALB
44	subdural empyema	10.2	F2 CRP
45	space motion sickness	10.2	REN AVP
46	giant hemangioma	10.2	F2 ALB
47	pericoronitis	10.2	TCF21 CRP
48	hemopneumothorax	10.2	F2 CRP
49	branch retinal artery occlusion	10.2	F2 CRP
50	hemopericardium	10.2	F2 CRP

Graphical network of the top 20 diseases related to Supine Hypotensive Syndrome:

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Symptoms & Phenotypes for Supine Hypotensive Syndrome

GenomeRNAi Phenotypes related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.17	ACR ALB AVP CRP CSH1 CSH2
2	no effect	GR00402-S-2	10.17	ACR ALB CRP CSH1 CSH2 DSC2

MGI Mouse Phenotypes related to Supine Hypotensive Syndrome:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.25	ALB AVP CRP CSH1 CSH2 F2
2	growth/size/body region	MP:0005378	10.18	CSH1 CSH2 DSC2 DSG2 DSP F2
3	muscle	MP:0005369	10.17	ALB DSC2 DSG2 DSP F2 INS
4	renal/urinary system	MP:0005367	10.16	ALB AVP CSH1 CSH2 INS LMNA
5	cardiovascular system	MP:0005385	10.13	ALB CRP CSH1 CSH2 DSC2 DSG2
6	immune system	MP:0005387	10	ALB AVP CRP CSH1 CSH2 DSC2
7	digestive/alimentary	MP:0005381	9.97	ALB DSC2 DSG2 DSP F2 INS
8	reproductive system	MP:0005389	9.65	ACR CSH1 CSH2 DSC2 F2 INS
9	mortality/aging	MP:0010768	9.53	ALB AVP CSH1 CSH2 DSC2 DSG2

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Drugs & Therapeutics for Supine Hypotensive Syndrome

Drugs for Supine Hypotensive Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Racephedrine

Approved, Experimental

Phase 4

299-42-3, 90-82-4, 90-81-3

5032 9294 7028

2

Norepinephrine

Approved

Phase 4

51-41-2

439260

3

Central Nervous System Stimulants

Phase 4

4

Neurotransmitter Agents

Phase 4

5

Adrenergic alpha-Agonists

Phase 4

6

Adrenergic Agonists

Phase 4

7

Adrenergic Agents

Phase 4

8

Sympathomimetics

Phase 4

9

Benzocaine

Approved, Investigational

1994-09-7, 94-09-7

2337

10

Tannic acid

Approved

1401-55-4

16129878 16129778

11

Vasoconstrictor Agents

12

Anesthetics

13

Antihypertensive Agents

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Norepinephrine Versus Ephedrin for Prevention of Post Spinal Anesthesia in Cesarean Section	Unknown status	NCT03719625	Phase 4	Ephedrine;Norepinephrine
2	Hemodynamic Management Target on Continuous Monitoring in Cesarean Delivery-A Randomized Controlled Trial in Patients With Supine Hypotensive Syndrome	Recruiting	NCT05341362
3	Comparison of Arm and Ankle Blood Pressure During Cesarean Delivery: A Blood Pressure Cuffs Pilot Study	Recruiting	NCT04934995

Search NIH Clinical Center for Supine Hypotensive Syndrome

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Genetic Tests for Supine Hypotensive Syndrome

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Anatomical Context for Supine Hypotensive Syndrome

Organs/tissues related to Supine Hypotensive Syndrome:

MalaCards : Uterus, Placenta

Sources

Publications for Supine Hypotensive Syndrome

Articles related to Supine Hypotensive Syndrome:

(show top 50) (show all 71)

#	Title	Authors	PMID	Year
1	Supine hypotensive syndrome of pregnancy: A review of current knowledge. ⁶²	Massoth C...Wenk M	34231500	2022
2	The effect of various pressure of pneumatic uterine bracket by using saccule sterine external stent on incidence of supine hypotensive syndrome. ⁶²	Xiao T...Wang J	33844258	2021
3	Perioperative management of a patient with a giant ovarian tumor: A case report. ⁶²	Cai S...Jiang Y	33031322	2020
4	Hemodynamic changes in women with symptoms of supine hypotensive syndrome. ⁶²	Humphries A...Stone P	31856296	2020
5	Aortocaval compression resulting in sudden loss of consciousness and severe bradycardia and hypotension during cesarean section in a patient with subvalvular aortic stenosis. ⁶²	Chen S...Jiang X	31272377	2019
6	A huge ovarian mucinous cystadenoma causing virilization, preterm labor, and persistent supine hypotensive syndrome during pregnancy. ⁶²	Kucur SK...Akyol A	27547742	2016
7	[Anesthetic Induction in a Patient with Giant Ovarian Tumor Who Developed Severe Hemodynamic Instability]. ⁶²	Aoi R...Takahashi K	26442415	2015
8	Prevention of supine hypotensive syndrome in pregnant women treated with transcranial magnetic stimulation. ⁶²	Kim DR...Wang E	24768354	2014
9	Sleep-disordered breathing in pregnancy: a review of the physiology and potential role for positional therapy. ⁶²	Morong S...de Vries N	23591835	2014
10	Anesthetic management of a patient with a giant ovarian tumor containing 83 l of fluid. ⁶²	Bamba K...Kohno T	24102044	2013
11	Supine hypotensive syndrome as the probable cause of both maternal and fetal death. ⁶²	De-Giorgio F...Arena V	22537582	2012
12	Pentax-AWS airway Scope as an alternative for awake flexible fiberoptic intubation of a morbidly obese patient in the semi-sitting position. ⁶²	Suzuki A...Iwasaki H	19234847	2009
13	Should we take a different angle in managing pregnant women at delivery? Attempting to avoid the 'supine hypotensive syndrome'. ⁶²	Paech MJ	19115642	2008
14	[Aortocaval compression syndrome]. ⁶²	Kiefer RT...Dieterich HJ	14992095	2003
15	[Thoracic epidural pressure and peripheral venous pressure in the lower extremity during supine hypotensive syndrome]. ⁶²	Kikutani T...Shimada Y	12795129	2003
16	Influence of maternal position during epidural labor analgesia. ⁶²	Soetens FM...Van Zundert AA	15321496	2003
17	Hemodynamic changes and baroreflex gain in the supine hypotensive syndrome. ⁶²	Lanni SM...Silver HM	12501076	2002
18	Laparoscopic surgery during pregnancy. ⁶²	Shay DC...Datta S	11244920	2001
19	Semi-Fowler's positioning, lateral tilts, and their effects on nonstress tests. ⁶²	Moffatt FW...van den Hof M	9313185	1997
20	Maternal position during labor: effects on fetal oxygen saturation measured by pulse oximetry. ⁶²	Carbonne B...Papiernik E	8885916	1996
21	The supine hypotensive syndrome. 1960. ⁶²	Holmes F	8678255	1995
22	[An unusual supine hypotensive syndrome during cesarean section: the importance of trying right tilt if there is a poor response to left tilt]. ⁶²	Hirabayashi Y...Shimizu R	7815712	1994
23	Supine hypotensive syndrome. ⁶²	Kinsella SM...Lohmann G	8164943	1994
24	[Cardiac arrests probably induced by hypermagnesemia during anesthesia for caesarean section]. ⁶²	Saitoh K...Shimizu R	8182885	1994
25	Maternal cerebral hemodynamics in the supine hypotensive syndrome. ⁶²	Ikeda T...Mori N	1727580	1992
26	[Replies to 8 questions asked about dental caring during pregnancy and nursing]. ⁶²	Alp Alantar S	1947586	1991
27	Uterine and umbilical flow velocity waveforms in the supine hypotensive syndrome. ⁶²	Pirhonen JP...Erkkola RU	2371021	1990
28	Cutaneous surgery and the pregnant patient. ⁶²	Gormley DE	2212124	1990
29	Oxygen saturation in the supine hypotensive syndrome. ⁶²	Calvin S...Weinstein L	3368171	1988
30	Factors influencing aortocaval compression in late pregnancy. ⁶²	Milsom I...Forssman L	6702946	1984
31	Bicornuate uterus and aortocaval compression. ⁶²	Magee DA	6846766	1983
32	[The echocardiographic observation of the cardiac function in normal pregnancy and supine hypotensive syndrome]. ⁶²	Arima N	7183051	1982
33	Death from a snake bite: associated with the supine hypotensive syndrome of pregnancy. ⁶²	Sutherland SK...Tibballs J	7132877	1982
34	'Postmortem' cesarean section with recovery of both mother and offspring. ⁶²	DePace NL...Kotler MN	7097967	1982
35	Supine hypotensive syndrome caused by intra-abdominal mass: a case report. ⁶²	Kim JM...McAmis F	1033713	1976
36	Role of the anaesthetist in the prevention of maternal deaths in Caesarian Section. ⁶²	Oyegunle AO	16295078	1976
37	[Changes of vein pressure and renal function by different positions of pregnant women. (A contribution to the supine hypotensive syndrome) (author's transl)]. ⁶²	Friedberg V...Gerteis R	4442681	1974
38	[Supine hypotensive syndrome and obstetric anaesthesia (author's transl)]. ⁶²	Lemtis H...Seger R	4437570	1974
39	[10 cases with a supine hypotensive syndrome (author's transl)]. ⁶²	Lemtis H...Seger R	4411550	1974
40	[Supine hypotensive syndrome in pregnancy]. ⁶²	Shimada N	4485053	1972
41	[Case of unusual form of collapse occurring during labor (supine hypotensive syndrome)]. ⁶²	Kolodziej K	5577769	1971
42	[Obstetric shock due to the supine hypotensive syndrome]. ⁶²	Avramov M	5093393	1971
43	[Supine hypotensive syndrome]. ⁶²	Sensing H	5732680	1968
44	[The vena-cava-inferior-syndrome (supine-hypotensive syndrome) in the late pregnancy]. ⁶²	Dieminger HJ	5696608	1968
45	[Collapse in a pregnant woman in supine position (supine hypotensive syndrome) as a possible cause of fetal death]. ⁶²	Otrebski W	5699703	1968
46	[Studies of the duration of the placental stage in various positions of the women. (Simultaneously a contribution on the problems of the supine hypotensive syndrome)]. ⁶²	Lemtis H...Saavedra JA	5595030	1967
47	[Shock due to supine hypotensive syndrome]. ⁶²	Kato J...Tanaka T	6071959	1967
48	Giant ovarian cyst and the supine hypotensive syndrome. ⁶²	Epstein RA...Panter GG	5946532	1966
49	SUPINE HYPOTENSIVE SYNDROME, SPINAL ANESTHESIA, AND APPARENT CARDIAC ARREST. A CASE REPORT. ⁶²	SHELD HH	14084156	1963
50	[Case of supine hypotensive syndrome]. ⁶²	KAWAHARA H...MOROHARA H	14031476	1963

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Genes for Supine Hypotensive Syndrome

Genes related to Supine Hypotensive Syndrome (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	LARS1	Leucyl-TRNA Synthetase 1	Protein Coding	5.76	DISEASES inferred ¹⁴
2	ACR	Acrosin	Protein Coding	5.22	DISEASES inferred ¹⁴
3	CSH1	Chorionic Somatomammotropin Hormone 1	Protein Coding	4.63	DISEASES inferred ¹⁴
4	CSH2	Chorionic Somatomammotropin Hormone 2	Protein Coding	4.58	DISEASES inferred ¹⁴
5	PKP2	Plakophilin 2	Protein Coding	3.86	DISEASES inferred ¹⁴
6	DSC2	Desmocollin 2	Protein Coding	3.78	DISEASES inferred ¹⁴
7	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	3.69	DISEASES inferred ¹⁴
8	DSG2	Desmoglein 2	Protein Coding	3.69	DISEASES inferred ¹⁴
9	REN	Renin	Protein Coding	3.62	DISEASES inferred ¹⁴
10	DSP	Desmoplakin	Protein Coding	3.56	DISEASES inferred ¹⁴
11	F2	Coagulation Factor II, Thrombin	Protein Coding	3.46	DISEASES inferred ¹⁴
12	TCF21	Transcription Factor 21	Protein Coding	3.38	DISEASES inferred ¹⁴
13	ITK	IL2 Inducible T Cell Kinase	Protein Coding	3.33	DISEASES inferred ¹⁴
14	INS	Insulin	Protein Coding	3.28	DISEASES inferred ¹⁴
15	KRT20	Keratin 20	Protein Coding	3.24	DISEASES inferred ¹⁴
16	CRP	C-Reactive Protein	Protein Coding	3.06	DISEASES inferred ¹⁴
17	ALB	Albumin	Protein Coding	2.99	DISEASES inferred ¹⁴
18	LMNA	Lamin A/C	Protein Coding	2.88	DISEASES inferred ¹⁴
19	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	2.87	DISEASES inferred ¹⁴
20	AVP	Arginine Vasopressin	Protein Coding	2.85	DISEASES inferred ¹⁴

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Variations for Supine Hypotensive Syndrome

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Expression for Supine Hypotensive Syndrome

Search GEO for disease gene expression data for Supine Hypotensive Syndrome.

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Pathways for Supine Hypotensive Syndrome

Pathways related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	DREAM Repression and Dynorphin Expression ⁶⁴ Show member pathways Arrhythmogenic right ventricular cardiomyopathy ⁷⁴ BMP Pathway ⁶⁴ Calpain Protease Regulates Cellular Mechanics ⁶⁴ Caspase Cascade ⁶⁴ nNOS Signaling in Skeletal Muscle ⁶⁴ Presynaptic depolarization and calcium channel opening ⁶⁶ TOB in Osteoblast Signaling ⁶⁴	12.22	PKP2 LMNA DSP DSG2 DSC2
2	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	11.56	PKP2 KRT20 DSP DSG2 DSC2
3	FOXA2 and FOXA3 transcription factor networks ⁶¹ Show member pathways FOXA transcription factor networks ⁶¹	10.77	INS F2 ALB
4	Vasopressin-like receptors ⁶⁶ Show member pathways Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) ⁶⁶ Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ⁶⁶	10.3	OXT AVP

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GO Terms for Supine Hypotensive Syndrome

Cellular components related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell junction	GO:0005911	9.91	PKP2 ITK DSP DSG2 DSC2
2	cornified envelope	GO:0001533	9.76	PKP2 DSP DSG2 DSC2
3	intercalated disc	GO:0014704	9.56	PKP2 DSP DSG2 DSC2
4	desmosome	GO:0030057	9.23	PKP2 DSP DSG2 DSC2

Biological processes related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	acute-phase response	GO:0006953	9.88	INS F2 CRP
2	regulation of heart rate by cardiac conduction	GO:0086091	9.86	DSC2 DSG2 DSP PKP2
3	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	9.85	F2 CSH2 CSH1
4	hyperosmotic salinity response	GO:0042538	9.73	OXT AVP
5	desmosome organization	GO:0002934	9.63	PKP2 DSP DSG2
6	maternal aggressive behavior	GO:0002125	9.62	OXT AVP
7	regulation of ventricular cardiac muscle cell action potential	GO:0098911	9.56	PKP2 DSP DSG2 DSC2
8	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	GO:0086073	9.23	PKP2 DSP DSG2 DSC2

Molecular functions related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.56	OXT INS CSH2 CSH1 AVP
2	neurohypophyseal hormone activity	GO:0005185	9.46	OXT AVP
3	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	GO:0086083	9.23	PKP2 DSP DSG2 DSC2

Sources

Sources for Supine Hypotensive Syndrome

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: SPN031 MIFTS: 37	Supine Hypotensive Syndrome Categories: Cardiovascular diseases	Data Licensing For inquiries, contact: [email protected]
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