MCID: SPN031
MIFTS: 37

Supine Hypotensive Syndrome

Categories: Cardiovascular diseases
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Aliases & Classifications for Supine Hypotensive Syndrome

MalaCards integrated aliases for Supine Hypotensive Syndrome:

Name: Supine Hypotensive Syndrome 11 14 33
Maternal Hypotension Syndrome 71 31 33
Maternal Hypotension Syndrome, Antepartum Condition or Complication 71
Maternal Hypotension Syndrome, Postpartum Condition or Complication 71
Maternal Hypotension Syndrome, Unspecified Trimester 33
Antepartum Maternal Hypotension Syndrome 11
Postpartum Maternal Hypotension Syndrome 11

Classifications:



External Ids:

Disease Ontology 11 DOID:10556
ICD9CM 34 669.20
ICD10 31 O26.5
ICD11 33 914484324
UMLS 71 C0157456 C0157459 C0157460 more

Summaries for Supine Hypotensive Syndrome

Disease Ontology: 11 A vascular disease that is characterized by severe supine hypotension in late pregnancy, whose clinical presentation ranges from minimal cardiovascular alterations to severe shock, resulting from inferior vena cava compression by gravid uterus.

MalaCards based summary: Supine Hypotensive Syndrome, also known as maternal hypotension syndrome, is related to major depressive disorder and testicular trophoblastic tumor. An important gene associated with Supine Hypotensive Syndrome is LARS1 (Leucyl-TRNA Synthetase 1), and among its related pathways/superpathways are DREAM Repression and Dynorphin Expression and Keratinization. The drugs Racephedrine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include uterus and placenta, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Supine Hypotensive Syndrome

Diseases related to Supine Hypotensive Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)
# Related Disease Score Top Affiliating Genes
1 major depressive disorder 28.7 OXT NR3C2 INS CRP AVP ALB
2 testicular trophoblastic tumor 10.4 CSH2 CSH1
3 non-gestational ovarian choriocarcinoma 10.4 CSH2 CSH1
4 gestational ovarian choriocarcinoma 10.4 CSH2 CSH1
5 choriocarcinoma of ovary 10.4 CSH2 CSH1
6 rh isoimmunization 10.4 CSH2 CSH1
7 fetishism 10.4 OXT LARS1
8 acquired hemangioma 10.4 OXT ACR
9 corpus luteum cyst 10.4 CSH2 CSH1
10 uterine inversion 10.3 OXT F2
11 non-gestational choriocarcinoma 10.3 CSH2 CSH1
12 placental abruption 10.3
13 iga pemphigus 10.3 DSP DSC2
14 arrhythmogenic right ventricular dysplasia, familial, 4 10.3 PKP2 DSG2 DSC2
15 epithelioid trophoblastic tumor 10.3 CSH2 CSH1
16 meckel's diverticulitis 10.3 LARS1 CRP
17 colonic lymphangioma 10.3 KRT20 ACR
18 urinary bladder small cell neuroendocrine carcinoma 10.3 KRT20 ACR
19 arrhythmogenic right ventricular dysplasia, familial, 10 10.3 PKP2 DSG2 DSC2
20 gestational trophoblastic neoplasm 10.3 OXT CSH2 CSH1
21 familial isolated arrhythmogenic right ventricular dysplasia 10.3 PKP2 DSP DSC2
22 protein-deficiency anemia 10.3 INS F2
23 ectopic pregnancy 10.2 OXT CSH2 CSH1
24 pyeloureteritis cystica 10.2 REN CRP
25 orbital osteomyelitis 10.2 F2 CRP
26 spontaneous tension pneumothorax 10.2 OXT CRP
27 nutmeg liver 10.2 ALB ACR
28 achenbach syndrome 10.2 F2 CRP
29 factitious disorder 10.2 INS F2
30 synovial angioma 10.2 F2 CRP
31 bullous skin disease 10.2 DSP DSG2 DSC2
32 emphysematous cholecystitis 10.2 F2 CRP
33 femoral neuropathy 10.2 F2 CRP
34 blue toe syndrome 10.2 F2 CRP
35 ureteric orifice cancer 10.2 INS F2
36 breast abscess 10.2 OXT CRP
37 renal pelvis squamous cell carcinoma 10.2 F2 CRP
38 subclavian steal syndrome 10.2 F2 CRP
39 hematocele of tunica vaginalis testis 10.2 F2 CRP
40 median arcuate ligament syndrome 10.2 TCF21 CRP
41 libman-sacks endocarditis 10.2 F2 CRP
42 nonbacterial thrombotic endocarditis 10.2 F2 CRP
43 orthostatic proteinuria 10.2 REN ALB
44 subdural empyema 10.2 F2 CRP
45 space motion sickness 10.2 REN AVP
46 giant hemangioma 10.2 F2 ALB
47 pericoronitis 10.2 TCF21 CRP
48 hemopneumothorax 10.2 F2 CRP
49 branch retinal artery occlusion 10.2 F2 CRP
50 hemopericardium 10.2 F2 CRP

Graphical network of the top 20 diseases related to Supine Hypotensive Syndrome:



Diseases related to Supine Hypotensive Syndrome

Symptoms & Phenotypes for Supine Hypotensive Syndrome

GenomeRNAi Phenotypes related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 ACR ALB AVP CRP CSH1 CSH2
2 no effect GR00402-S-2 10.17 ACR ALB CRP CSH1 CSH2 DSC2

MGI Mouse Phenotypes related to Supine Hypotensive Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ALB AVP CRP CSH1 CSH2 F2
2 growth/size/body region MP:0005378 10.18 CSH1 CSH2 DSC2 DSG2 DSP F2
3 muscle MP:0005369 10.17 ALB DSC2 DSG2 DSP F2 INS
4 renal/urinary system MP:0005367 10.16 ALB AVP CSH1 CSH2 INS LMNA
5 cardiovascular system MP:0005385 10.13 ALB CRP CSH1 CSH2 DSC2 DSG2
6 immune system MP:0005387 10 ALB AVP CRP CSH1 CSH2 DSC2
7 digestive/alimentary MP:0005381 9.97 ALB DSC2 DSG2 DSP F2 INS
8 reproductive system MP:0005389 9.65 ACR CSH1 CSH2 DSC2 F2 INS
9 mortality/aging MP:0010768 9.53 ALB AVP CSH1 CSH2 DSC2 DSG2

Drugs & Therapeutics for Supine Hypotensive Syndrome

Drugs for Supine Hypotensive Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racephedrine Approved, Experimental Phase 4 299-42-3, 90-82-4, 90-81-3 5032 9294 7028
2
Norepinephrine Approved Phase 4 51-41-2 439260
3 Central Nervous System Stimulants Phase 4
4 Neurotransmitter Agents Phase 4
5 Adrenergic alpha-Agonists Phase 4
6 Adrenergic Agonists Phase 4
7 Adrenergic Agents Phase 4
8 Sympathomimetics Phase 4
9
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
10
Tannic acid Approved 1401-55-4 16129878 16129778
11 Vasoconstrictor Agents
12 Anesthetics
13 Antihypertensive Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Norepinephrine Versus Ephedrin for Prevention of Post Spinal Anesthesia in Cesarean Section Unknown status NCT03719625 Phase 4 Ephedrine;Norepinephrine
2 Hemodynamic Management Target on Continuous Monitoring in Cesarean Delivery-A Randomized Controlled Trial in Patients With Supine Hypotensive Syndrome Recruiting NCT05341362
3 Comparison of Arm and Ankle Blood Pressure During Cesarean Delivery: A Blood Pressure Cuffs Pilot Study Recruiting NCT04934995

Search NIH Clinical Center for Supine Hypotensive Syndrome

Genetic Tests for Supine Hypotensive Syndrome

Anatomical Context for Supine Hypotensive Syndrome

Organs/tissues related to Supine Hypotensive Syndrome:

MalaCards : Uterus, Placenta

Publications for Supine Hypotensive Syndrome

Articles related to Supine Hypotensive Syndrome:

(show top 50) (show all 71)
# Title Authors PMID Year
1
Supine hypotensive syndrome of pregnancy: A review of current knowledge. 62
34231500 2022
2
The effect of various pressure of pneumatic uterine bracket by using saccule sterine external stent on incidence of supine hypotensive syndrome. 62
33844258 2021
3
Perioperative management of a patient with a giant ovarian tumor: A case report. 62
33031322 2020
4
Hemodynamic changes in women with symptoms of supine hypotensive syndrome. 62
31856296 2020
5
Aortocaval compression resulting in sudden loss of consciousness and severe bradycardia and hypotension during cesarean section in a patient with subvalvular aortic stenosis. 62
31272377 2019
6
A huge ovarian mucinous cystadenoma causing virilization, preterm labor, and persistent supine hypotensive syndrome during pregnancy. 62
27547742 2016
7
[Anesthetic Induction in a Patient with Giant Ovarian Tumor Who Developed Severe Hemodynamic Instability]. 62
26442415 2015
8
Prevention of supine hypotensive syndrome in pregnant women treated with transcranial magnetic stimulation. 62
24768354 2014
9
Sleep-disordered breathing in pregnancy: a review of the physiology and potential role for positional therapy. 62
23591835 2014
10
Anesthetic management of a patient with a giant ovarian tumor containing 83 l of fluid. 62
24102044 2013
11
Supine hypotensive syndrome as the probable cause of both maternal and fetal death. 62
22537582 2012
12
Pentax-AWS airway Scope as an alternative for awake flexible fiberoptic intubation of a morbidly obese patient in the semi-sitting position. 62
19234847 2009
13
Should we take a different angle in managing pregnant women at delivery? Attempting to avoid the 'supine hypotensive syndrome'. 62
19115642 2008
14
[Aortocaval compression syndrome]. 62
14992095 2003
15
[Thoracic epidural pressure and peripheral venous pressure in the lower extremity during supine hypotensive syndrome]. 62
12795129 2003
16
Influence of maternal position during epidural labor analgesia. 62
15321496 2003
17
Hemodynamic changes and baroreflex gain in the supine hypotensive syndrome. 62
12501076 2002
18
Laparoscopic surgery during pregnancy. 62
11244920 2001
19
Semi-Fowler's positioning, lateral tilts, and their effects on nonstress tests. 62
9313185 1997
20
Maternal position during labor: effects on fetal oxygen saturation measured by pulse oximetry. 62
8885916 1996
21
The supine hypotensive syndrome. 1960. 62
8678255 1995
22
[An unusual supine hypotensive syndrome during cesarean section: the importance of trying right tilt if there is a poor response to left tilt]. 62
7815712 1994
23
Supine hypotensive syndrome. 62
8164943 1994
24
[Cardiac arrests probably induced by hypermagnesemia during anesthesia for caesarean section]. 62
8182885 1994
25
Maternal cerebral hemodynamics in the supine hypotensive syndrome. 62
1727580 1992
26
[Replies to 8 questions asked about dental caring during pregnancy and nursing]. 62
1947586 1991
27
Uterine and umbilical flow velocity waveforms in the supine hypotensive syndrome. 62
2371021 1990
28
Cutaneous surgery and the pregnant patient. 62
2212124 1990
29
Oxygen saturation in the supine hypotensive syndrome. 62
3368171 1988
30
Factors influencing aortocaval compression in late pregnancy. 62
6702946 1984
31
Bicornuate uterus and aortocaval compression. 62
6846766 1983
32
[The echocardiographic observation of the cardiac function in normal pregnancy and supine hypotensive syndrome]. 62
7183051 1982
33
Death from a snake bite: associated with the supine hypotensive syndrome of pregnancy. 62
7132877 1982
34
'Postmortem' cesarean section with recovery of both mother and offspring. 62
7097967 1982
35
Supine hypotensive syndrome caused by intra-abdominal mass: a case report. 62
1033713 1976
36
Role of the anaesthetist in the prevention of maternal deaths in Caesarian Section. 62
16295078 1976
37
[Changes of vein pressure and renal function by different positions of pregnant women. (A contribution to the supine hypotensive syndrome) (author's transl)]. 62
4442681 1974
38
[Supine hypotensive syndrome and obstetric anaesthesia (author's transl)]. 62
4437570 1974
39
[10 cases with a supine hypotensive syndrome (author's transl)]. 62
4411550 1974
40
[Supine hypotensive syndrome in pregnancy]. 62
4485053 1972
41
[Case of unusual form of collapse occurring during labor (supine hypotensive syndrome)]. 62
5577769 1971
42
[Obstetric shock due to the supine hypotensive syndrome]. 62
5093393 1971
43
[Supine hypotensive syndrome]. 62
5732680 1968
44
[The vena-cava-inferior-syndrome (supine-hypotensive syndrome) in the late pregnancy]. 62
5696608 1968
45
[Collapse in a pregnant woman in supine position (supine hypotensive syndrome) as a possible cause of fetal death]. 62
5699703 1968
46
[Studies of the duration of the placental stage in various positions of the women. (Simultaneously a contribution on the problems of the supine hypotensive syndrome)]. 62
5595030 1967
47
[Shock due to supine hypotensive syndrome]. 62
6071959 1967
48
Giant ovarian cyst and the supine hypotensive syndrome. 62
5946532 1966
49
SUPINE HYPOTENSIVE SYNDROME, SPINAL ANESTHESIA, AND APPARENT CARDIAC ARREST. A CASE REPORT. 62
14084156 1963
50
[Case of supine hypotensive syndrome]. 62
14031476 1963

Variations for Supine Hypotensive Syndrome

Expression for Supine Hypotensive Syndrome

Search GEO for disease gene expression data for Supine Hypotensive Syndrome.

Pathways for Supine Hypotensive Syndrome

Pathways related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 PKP2 LMNA DSP DSG2 DSC2
2
Show member pathways
11.56 PKP2 KRT20 DSP DSG2 DSC2
3
Show member pathways
10.77 INS F2 ALB
4
Show member pathways
10.3 OXT AVP

GO Terms for Supine Hypotensive Syndrome

Cellular components related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 9.91 PKP2 ITK DSP DSG2 DSC2
2 cornified envelope GO:0001533 9.76 PKP2 DSP DSG2 DSC2
3 intercalated disc GO:0014704 9.56 PKP2 DSP DSG2 DSC2
4 desmosome GO:0030057 9.23 PKP2 DSP DSG2 DSC2

Biological processes related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.88 INS F2 CRP
2 regulation of heart rate by cardiac conduction GO:0086091 9.86 DSC2 DSG2 DSP PKP2
3 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.85 F2 CSH2 CSH1
4 hyperosmotic salinity response GO:0042538 9.73 OXT AVP
5 desmosome organization GO:0002934 9.63 PKP2 DSP DSG2
6 maternal aggressive behavior GO:0002125 9.62 OXT AVP
7 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.56 PKP2 DSP DSG2 DSC2
8 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.23 PKP2 DSP DSG2 DSC2

Molecular functions related to Supine Hypotensive Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.56 OXT INS CSH2 CSH1 AVP
2 neurohypophyseal hormone activity GO:0005185 9.46 OXT AVP
3 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 9.23 PKP2 DSP DSG2 DSC2

Sources for Supine Hypotensive Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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