MCID: SPP007
MIFTS: 38

Suppression Amblyopia

Categories: Neuronal diseases

Aliases & Classifications for Suppression Amblyopia

MalaCards integrated aliases for Suppression Amblyopia:

Name: Suppression Amblyopia 12 15
Amblyopia 44 71
Amblyopia, Suppression 71
Strabismic Amblyopia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10375
ICD9CM 34 368.01
MeSH 44 D000550
SNOMED-CT 67 35600002
ICD10 32 H53.03
UMLS 71 C0002418 C0750903

Summaries for Suppression Amblyopia

MalaCards based summary : Suppression Amblyopia, also known as amblyopia, is related to esotropia and paralytic squint, and has symptoms including photophobia, other specified visual disturbances and visual disturbance. An important gene associated with Suppression Amblyopia is HNMT (Histamine N-Methyltransferase). The drugs Atropine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, cortex and brain, and related phenotype is nervous system.

Related Diseases for Suppression Amblyopia

Diseases related to Suppression Amblyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
# Related Disease Score Top Affiliating Genes
1 esotropia 31.0 PHOX2A CHN1
2 paralytic squint 31.0 PHOX2A MTRNR2L5 CHN1
3 anisometropia 30.6 PHOX2A HNMT CHN1
4 congenital ptosis 30.4 PHOX2A CHN1
5 accommodative esotropia 30.3 PHOX2A CHN1
6 exotropia 30.2 PHOX2A CHN1
7 amblyopia 30.2 SIRPA PHOX2A HNMT CHN1
8 hypotropia 29.9 PHOX2A CHN1
9 hypertropia 29.9 PHOX2A CHN1
10 ocular motility disease 29.8 PHOX2A CHN1
11 facial paralysis 29.5 MTRNR2L5 MTRNR2L4
12 ametropic amblyopia 29.5 PHOX2A MTRNR2L5 MTRNR2L4 CHN1
13 microphthalmia, isolated 6 11.3
14 disuse amblyopia 11.3
15 astigmatism 11.1
16 farsightedness 11.1
17 duane retraction syndrome 1 11.0
18 blepharophimosis, ptosis, and epicanthus inversus 11.0
19 duane retraction syndrome 2 11.0
20 corneal dystrophy, congenital stromal 11.0
21 bestrophinopathy, autosomal recessive 11.0
22 cerulean cataract 11.0
23 mental and growth retardation with amblyopia 10.9
24 microphthalmia 10.9
25 peters-plus syndrome 10.9
26 hemifacial hyperplasia with strabismus 10.8
27 isolated ectopia lentis 10.8
28 aniridia 1 10.8
29 aniridia and absent patella 10.8
30 cataract 41 10.8
31 fibrosis of extraocular muscles, congenital, 1 10.8
32 bornholm eye disease 10.8
33 fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement 10.8
34 mental retardation, anterior maxillary protrusion, and strabismus 10.8
35 cognitive impairment with or without cerebellar ataxia 10.8
36 duane retraction syndrome 3 with or without deafness 10.8
37 aniridia 2 10.8
38 catifa syndrome 10.8
39 hivep2-related intellectual disability 10.8
40 isolated duane retraction syndrome 10.8
41 monocular esotropia 10.6
42 cataract 10.6
43 ptosis 10.5
44 eye disease 10.5
45 refractive error 10.5
46 pathologic nystagmus 10.4
47 ocular dominance 10.4
48 hemangioma 10.3
49 lacrimal duct defect 10.2
50 microvascular complications of diabetes 5 10.2

Graphical network of the top 20 diseases related to Suppression Amblyopia:



Diseases related to Suppression Amblyopia

Symptoms & Phenotypes for Suppression Amblyopia

UMLS symptoms related to Suppression Amblyopia:


photophobia, other specified visual disturbances, visual disturbance

MGI Mouse Phenotypes related to Suppression Amblyopia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 CHN1 GPR17 GRM6 HNMT ITPRIP PHOX2A

Drugs & Therapeutics for Suppression Amblyopia

Drugs for Suppression Amblyopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
2 Neurotransmitter Agents Phase 4
3 Cholinergic Agents Phase 4
4 Anti-Asthmatic Agents Phase 4
5 Respiratory System Agents Phase 4
6 Anesthetics Phase 4
7 Cholinergic Antagonists Phase 4
8 Muscarinic Antagonists Phase 4
9 Bronchodilator Agents Phase 4
10 Parasympatholytics Phase 4
11 Anti-Arrhythmia Agents Phase 4
12
Levodopa Approved Phase 3 59-92-7 6047
13
Carbidopa Approved Phase 3 28860-95-9 34359
14 Antiparkinson Agents Phase 3
15 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3
16 Omega 3 Fatty Acid Phase 1, Phase 2
17
Pentetic acid Approved Phase 1 67-43-6
18
Edetic Acid Approved, Vet_approved Phase 1 60-00-4, 62-33-9 6049
19
Ethanol Approved Phase 1 64-17-5 702
20
Benzyl alcohol Approved Phase 1 100-51-6 244
21
Donepezil Approved Phase 1 120014-06-4 3152
22 Ophthalmic Solutions Phase 1
23 Pharmaceutical Solutions Phase 1
24 Antidotes Phase 1
25 Cholinesterase Inhibitors Phase 1
26
Cocaine Approved, Illicit 50-36-2 5760 446220
27
Calcium carbonate Approved, Investigational 471-34-1
28 Tomato Approved
29
Methamphetamine Approved, Illicit 537-46-2 10836
30
Dopamine Approved 51-61-6, 62-31-7 681
31 Vaccines
32 Dopamine Agents
33 Dopamine Uptake Inhibitors
34 Sympathomimetics
35 Adrenergic Agents

Interventional clinical trials:

(show top 50) (show all 115)
# Name Status NCT ID Phase Drugs
1 The Effect of Donepezil on Perceptual Learning in Adult Amblyopia Completed NCT03109314 Phase 4 Donepezil
2 A Randomized Trial Comparing Daily Atropine Versus Weekend Atropine Completed NCT00094614 Phase 4 Atropine
3 Vision In Preschoolers Study (VIP Study) Unknown status NCT00038753 Phase 3
4 A Randomized Trial Comparing Near Versus Distance Activities While Patching for Amblyopia in Children 3 to <7 Years Old Completed NCT00315198 Phase 3
5 Amblyopia Treatment Study: Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia Completed NCT00000170 Phase 3 Atropine
6 A Randomized Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds Completed NCT00315328 Phase 3 Atropine
7 A Randomized Trial Comparing Part-time Versus Full-time Patching for Severe Amblyopia Completed NCT00094744 Phase 3
8 A Randomized Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye As Prescribed Treatments for Amblyopia in Children 3 to <7 Years Old Completed NCT00315302 Phase 3 Atropine
9 Electronic Recording of Compliance With Occlusion Therapy for Amblyopia: 1 Effects of Patient Education on Compliance 2 Predictors for Non-Compliance Completed NCT00131729 Phase 3
10 An Evaluation of Treatment of Amblyopia in 7 To <18 Year Olds Completed NCT00094692 Phase 3 atropine
11 A Randomized Trial to Evaluate 2 Hours of Daily Patching for Amblyopia in Children 3 to <7 Years Old Completed NCT00091923 Phase 3
12 Increasing Patching for Amblyopia in Children 3 to < 8 Years Old Completed NCT00945100 Phase 3
13 Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old Completed NCT00944710 Phase 3 Atropine;Atropine
14 A Randomized Trial of Levodopa as Treatment for Residual Amblyopia (ATS 17) Completed NCT01190813 Phase 3 Levodopa/Carbidopa;Placebo
15 A Randomized Trial Comparing Part-time Versus Minimal-time Patching for Moderate Amblyopia Completed NCT00094679 Phase 3
16 Amblyopia Treatment Study Completed NCT00001864 Phase 3 Atropine
17 Anisometropia Amblyopia Improved by Perceptual Learning and Patching Completed NCT00498641 Phase 3
18 A Randomized Trial of Full-time Bangerter Filters Versus Part-time Daily Patching for the Treatment of Moderate Amblyopia in Children Completed NCT00525174 Phase 3
19 A Randomized Trial Comparing Patching With Active Vision Therapy to Patching With Control Vision Therapy as Treatment for Amblyopia in Children 7 to <13 Years Old Terminated NCT00587171 Phase 3
20 A Randomized Trial to Evaluate Combined Patching-Atropine for Residual Amblyopia Terminated NCT00506675 Phase 3 Atropine;Atropine
21 Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia? Completed NCT01308307 Phase 2
22 Evaluation and Development of a Novel Binocular Treatment (I-BiTTM) System Using Video Clips and Interactive Games to Improve Vision in Children With Amblyopia ('Lazy Eye'). Completed NCT01702727 Phase 2
23 A Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia in 8 to 17 Year Olds Completed NCT00789672 Phase 2 levodopa/carbidopa;levodopa/carbidopa
24 Effectiveness of Telescopic Magnification in the Treatment of Amblyopia Completed NCT00970554 Phase 1, Phase 2
25 Comparison of Photorefraction With Cycloautorefraction and Cycloretinoscopy at Emam Hosein Medical Centre in 2008-2009 Completed NCT00815581 Phase 1, Phase 2
26 Pilot Study to Evaluate Docosahexaenoic Acid as Treatment for Residual Amblyopia Not yet recruiting NCT03402789 Phase 1, Phase 2 Docosahexaenoic Acid;Placebo Oral Tablet
27 Caffeine in Amblyopia Study Withdrawn NCT02594358 Phase 1, Phase 2 Caffeine
28 Randomised Occlusion Treatment of Amblyopia Study (ROTAS): Trial of Maximal Vs Substantial Doses of Occlusion to Evaluate Visual Outcome for Children With Amblyopia Completed NCT00274664 Phase 1
29 A Randomized, Three-Sequence, Three-Period Crossover Study to Assess the Bioavailability and Pharmacokinetics of a Single Dose of Atropine Administered Sublingually in Healthy Adult Volunteers Completed NCT04290039 Phase 1 Atropine Sulfate Ophthalmic Solution;Atropine Sulphate Injection
30 Investigation of Visual Plasticity by a Direct Current Stimulation of Occipital Cortex in Adult Amblyopia Completed NCT00097162 Phase 1
31 Recovery From Amblyopia With Cholinesterase Inhibitors Recruiting NCT01584076 Phase 1 Donepezil
32 Dichoptic Virtual Reality Therapy for Amblyopia in Adults Terminated NCT02246556 Phase 1
33 Efficacy and Safety of Eyetronix Flicker Glasses to the Treatment of Anisometropic Amblyopia in Chinese Children Unknown status NCT02970708
34 The Use of Interactive Binocular Treatment (I-BiT) for the Management of Anisometropic, Strabismic and Mixed Amblyopia in Children Aged 3.5 - 12 Years Unknown status NCT02810847
35 Visual Functional Connectivity and Visual Function in Amblyopia Before and After TMS and/or Binocular Treatment Unknown status NCT03151200
36 A Randomised Clinical Trial Objectively Comparing the Effect of Patching Therapy With Video Gaming for Amblyopia Unknown status NCT03767985
37 Determining the Efficacy of Full-time Occlusion Therapy in Severe Amblyopia at All Ages Unknown status NCT02113709
38 The Role of Interactive Binocular Treatment System in Amblyopia Therapy Unknown status NCT02740725
39 A Comparative Study Between Dissociative Treatment and Binocular Interactive Treatment in Amblyopia Unknown status NCT03255707
40 Early Vision Screening With Automated Photorefraction in Pre-term, Low-birth- Weight and Development-delay Children in Far-Eastern Memorial Hospital, Taiwan Unknown status NCT02678468
41 MRI-based Biomarkers for the Prognosis Judgement of Punctate White Matter Lesions in Neonates: a Longitudinal Multicenter Study Unknown status NCT02637817
42 Bilateral Refractive Amblyopia Treatment Study Completed NCT00305955
43 Vision Screening of the Four Year Old Children for the Detection of Amblyopia in The Town of Zagreb Completed NCT01430247
44 Will Perceptual Learning Via Video Game Playing Improve Visual Acuity, Stereopsis and Fixation Stability in Mild Amblyopes? Part 2 Study Completed NCT02995174
45 An Observational Study of Optical Correction for Strabismic Amblyopia in Children 3 to <7 Years Old Completed NCT00669539
46 Refractive and Strabismic Amblyopia Risk Factors Detected by Infrared Photoscreener and School Bus Skiascopy Completed NCT03668067
47 Comparative Validation of the Birefringent Amblyopia Screener With Isolated Small-angle Strabismus Completed NCT04195711
48 Prospective Evaluation of a Smartphone Application, GoCheckKids™ as a Photo Screening Tool in a Pediatric Population Completed NCT03119675
49 Prospective Evaluation of a Smartphone Application, GoCheckKids™, to Detect Amblyopia Risk Factors in Young Children Completed NCT03447171
50 Multimodal Physician Intervention to Detect Amblyopia (Recruiting Title "Equipping Primary Care Physicians to Improve Care for Children") Completed NCT01109459

Search NIH Clinical Center for Suppression Amblyopia

Cochrane evidence based reviews: amblyopia

Genetic Tests for Suppression Amblyopia

Anatomical Context for Suppression Amblyopia

MalaCards organs/tissues related to Suppression Amblyopia:

40
Eye, Cortex, Brain, Retina, Endothelial, Pituitary, Thalamus

Publications for Suppression Amblyopia

Articles related to Suppression Amblyopia:

(show top 50) (show all 7349)
# Title Authors PMID Year
1
Motor Competence in Children With and Without Ambliopia. 61
33435851 2021
2
Presentation, surgery and 1-year outcomes of childhood cataract surgery in Tanzania. 61
32522793 2021
3
Ocular biometric measurements and optical coherence tomography parameters in children with refractive errors and emmetropia. 61
33463576 2021
4
Progression From Soft Lens to Piggyback Soft-Scleral Contact Lens System to Facilitate Scleral Lens Use in a Pediatric Patient. 61
33605634 2021
5
[Vision screening for children: Recommended practices from AFSOP]. 61
33388188 2021
6
Brown syndrome: clinical features and results of superior oblique tenotomy. 61
33567010 2021
7
Perceptual learning improves visual functions in patients with albinistic bilateral amblyopia: A pilot study. 61
33554927 2021
8
Is hypermetropia regressing in accommodative esotropia? 61
33567009 2021
9
Predicting Risk Factors for Consecutive Esotropia Failed with Conservative Therapy. 61
33587682 2021
10
The Flash-lag Effect in Amblyopia. 61
33599734 2021
11
The use of atropine for treatment of amblyopia using the OptumLabs Data Warehouse. 61
33348039 2021
12
Long-term follow-up of an amblyopia treatment study: change in visual acuity 15 years after occlusion therapy. 61
32657530 2021
13
Knowledge and attitudes regarding amblyopia among parents in Jeddah, Saudi Arabia: a cross-sectional study. 61
33568219 2021
14
Corrigendum to "l-Dopa methyl ester attenuates amblyopia-induced neuronal injury in visual cortex of amblyopic cat" [Gene 527 (2013) 115-122]. 61
33581886 2021
15
Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia. 61
33542265 2021
16
Visual preservation in congenital orbital fibrosis. 61
32771329 2021
17
Ocular Phenotype Associated with DYRK1A Variants. 61
33562844 2021
18
Amblyopia and Refractive Status in Congenital Ptosis: The Effect and Timing of Surgical Correction. 61
33538502 2021
19
Video interpretation and diagnosis of pediatric amblyopia and eye disease. 61
31364472 2021
20
Quality of life and functional vision across pediatric eye conditions assessed using the PedEyeQ. 61
33601046 2021
21
Clinical characteristics and treatment of secondary glaucoma, glaucoma suspects and ocular hypertension after congenital cataract surgery. 61
33525900 2021
22
Referral outcomes from a vision screening program for school-aged children. 61
32771327 2021
23
Costs and effects of conventional vision screening and photoscreening in the Dutch preventive child health care system. 61
32893298 2021
24
Macular capillary system and ganglion cell-layer complex of the amblyopic eye with optical cohorence tomography angiography and optical cohorence tomography. 61
33079311 2021
25
Small incision lenticule extraction retreatment in a patient with high residual refractive error after photorefractive keratectomy: A case report. 61
33273152 2021
26
Analysis of suspected visual impairment risks based on objective refraction in 3-year-old children. 61
33598802 2021
27
Atypical presentation of peripheral posterior lenticonus and role of multi-modal ocular imaging in its diagnosis and management. 61
33547123 2021
28
Amblyopia screening effectiveness at 3-4 years old: a cohort study. 61
33437872 2021
29
Co-existence of myopia and amblyopia in a guinea pig model with monocular form deprivation. 61
33569412 2021
30
Effect of amblyopia treatment on macular microvasculature in children with anisometropic amblyopia using optical coherence tomographic angiography. 61
33420155 2021
31
Refinement strategies in photoscreening for the detection of amblyopia risk factors in 12-to-24-month-old children. 61
32223997 2021
32
Psychomotor, Psychosocial and Reading Skills in Children with Amblyopia and the Effect of Different Treatments. 61
32281918 2021
33
Prevalence of amblyopia and its determinants in a rural population: a population-based cross-sectional study. 61
33455499 2021
34
Amblyopia. 61
33496776 2021
35
Organic visual loss measured by kinetic perimetry and retinal electrophysiology in children with functional amblyopia. 61
33515394 2021
36
Efficacy of part-time occlusion in amblyopia in Indian children. 61
33323591 2021
37
Commentary: Part time occlusion for amblyopia: The unsung hero! 61
33323592 2021
38
Treatment of Congenital Ptosis in Infants With Associated Amblyopia Using a Frontalis Muscle Flap Eyelid Reanimation Technique. 61
32467524 2021
39
Outcomes of pediatric accommodative esotropia with botulinum toxin A treatment in Thailand. 61
33404269 2021
40
Instrument-based screening for amblyopia risk factors in a primary care setting in children aged 18 to 30 months. 61
33410941 2021
41
Neuroplasticity of the visual cortex: in sickness and in health. 61
33132181 2021
42
Surgical outcomes of cataract surgery in anterior and combined persistent fetal vasculature using a novel surgical technique: a single center, prospective study. 61
32803327 2021
43
Prevalence of Ophthalmologic Diagnoses in Children With Autism Spectrum Disorder Using the Optum Dataset: APopulation-Based Study. 61
32896499 2021
44
Teleophthalmology: Evaluation of Phone-based Visual Acuity in a Pediatric Population. 61
32791067 2021
45
Technical Report: A New Device Attached to a Smartphone for Objective Vision Screening. 61
33394927 2021
46
Ophthalmology examination during well-child visits in primary care health centres: Knowledge and difficulties experienced by health workers. 61
33067032 2021
47
Horizontal rectus muscle transplantation for recurrent and residual strabismus. 61
33470875 2021
48
Ocular manifestations and surgical interventions in pediatric patients with Koolen-de-Vries syndrome. 61
33393407 2021
49
Neuro-Ophthalmological Manifestations of Craniosynostosis: Current Perspectives. 61
33542671 2021
50
Impaired visual acuity caused by uncorrected refractive errors and amblyopia in a German paediatric cohort. 61
33104264 2021

Variations for Suppression Amblyopia

Expression for Suppression Amblyopia

Search GEO for disease gene expression data for Suppression Amblyopia.

Pathways for Suppression Amblyopia

GO Terms for Suppression Amblyopia

Biological processes related to Suppression Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of signaling receptor activity GO:2000272 8.96 MTRNR2L5 MTRNR2L4
2 negative regulation of execution phase of apoptosis GO:1900118 8.62 MTRNR2L5 MTRNR2L4

Molecular functions related to Suppression Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor antagonist activity GO:0048019 8.62 MTRNR2L5 MTRNR2L4

Sources for Suppression Amblyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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