Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: SPP007
MIFTS: 38

Suppression Amblyopia

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Suppression Amblyopia

About this section

MalaCards integrated aliases for Suppression Amblyopia:

Name: Suppression Amblyopia 12 15
Amblyopia 44 70
Amblyopia, Suppression 70
Strabismic Amblyopia 12

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10375
ICD9CM 34 368.01
MeSH 44 D000550
SNOMED-CT 67 35600002
ICD10 32 H53.03
UMLS 70 C0002418 C0750903
Sources

Summaries for Suppression Amblyopia

About this section
MalaCards based summary : Suppression Amblyopia, also known as amblyopia, is related to esotropia and paralytic squint, and has symptoms including photophobia, other specified visual disturbances and visual disturbance. An important gene associated with Suppression Amblyopia is HNMT (Histamine N-Methyltransferase). The drugs Atropine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, cortex and brain, and related phenotype is nervous system.

Sources

Related Diseases for Suppression Amblyopia

About this section

Diseases related to Suppression Amblyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
# Related Disease Score Top Affiliating Genes
1 esotropia 31.0 PHOX2A CHN1
2 paralytic squint 31.0 PHOX2A MTRNR2L5 CHN1
3 anisometropia 30.6 PHOX2A HNMT CHN1
4 amblyopia 30.5 SIRPA HNMT CHN1
5 congenital ptosis 30.4 PHOX2A CHN1
6 accommodative esotropia 30.4 PHOX2A CHN1
7 exotropia 30.2 PHOX2A CHN1
8 hypotropia 29.9 PHOX2A CHN1
9 hypertropia 29.9 PHOX2A CHN1
10 ocular motility disease 29.9 PHOX2A CHN1
11 facial paralysis 29.5 MTRNR2L5 MTRNR2L4
12 ametropic amblyopia 29.5 PHOX2A MTRNR2L5 MTRNR2L4 CHN1
13 microphthalmia, isolated 6 11.3
14 disuse amblyopia 11.3
15 astigmatism 11.1
16 farsightedness 11.1
17 duane retraction syndrome 1 11.0
18 blepharophimosis, ptosis, and epicanthus inversus 11.0
19 duane retraction syndrome 2 11.0
20 corneal dystrophy, congenital stromal 11.0
21 bestrophinopathy, autosomal recessive 11.0
22 cerulean cataract 11.0
23 mental and growth retardation with amblyopia 10.9
24 albinism 10.9
25 microphthalmia 10.9
26 peters-plus syndrome 10.9
27 hemifacial hyperplasia with strabismus 10.8
28 isolated ectopia lentis 10.8
29 aniridia 1 10.8
30 aniridia and absent patella 10.8
31 cataract 41 10.8
32 fibrosis of extraocular muscles, congenital, 1 10.8
33 bornholm eye disease 10.8
34 fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement 10.8
35 mental retardation, anterior maxillary protrusion, and strabismus 10.8
36 cognitive impairment with or without cerebellar ataxia 10.8
37 duane retraction syndrome 3 with or without deafness 10.8
38 aniridia 2 10.8
39 catifa syndrome 10.8
40 cataract microcornea syndrome 10.8
41 hivep2-related intellectual disability 10.8
42 isolated duane retraction syndrome 10.8
43 monocular esotropia 10.6
44 cataract 10.6
45 ptosis 10.5
46 eye disease 10.5
47 refractive error 10.5
48 pathologic nystagmus 10.4
49 ocular dominance 10.4
50 hemangioma 10.3

Graphical network of the top 20 diseases related to Suppression Amblyopia:



Diseases related to Suppression Amblyopia
Sources

Symptoms & Phenotypes for Suppression Amblyopia

About this section

UMLS symptoms related to Suppression Amblyopia:


photophobia; other specified visual disturbances; visual disturbance

MGI Mouse Phenotypes related to Suppression Amblyopia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 CHN1 GPR17 GRM6 HNMT ITPRIP PHOX2A
Sources

Drugs & Therapeutics for Suppression Amblyopia

About this section

Drugs for Suppression Amblyopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
2 Neurotransmitter Agents Phase 4
3 Cholinergic Agents Phase 4
4 Anti-Arrhythmia Agents Phase 4
5 Respiratory System Agents Phase 4
6 Anti-Asthmatic Agents Phase 4
7 Anesthetics Phase 4
8 Muscarinic Antagonists Phase 4
9 Cholinergic Antagonists Phase 4
10 Mydriatics Phase 4
11 Parasympatholytics Phase 4
12 Bronchodilator Agents Phase 4
13
Levodopa Approved Phase 3 59-92-7 6047
14
Carbidopa Approved Phase 3 28860-95-9 34359
15 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3
16 Antiparkinson Agents Phase 3
17 Omega 3 Fatty Acid Phase 1, Phase 2
18
Ethanol Approved Phase 1 64-17-5 702
19
Edetic Acid Approved, Vet_approved Phase 1 60-00-4, 62-33-9 6049
20
Pentetic acid Approved Phase 1 67-43-6
21
Benzyl alcohol Approved Phase 1 100-51-6 244
22
Donepezil Approved Phase 1 120014-06-4 3152
23 Antidotes Phase 1
24 Pharmaceutical Solutions Phase 1
25 Cholinesterase Inhibitors Phase 1
26 Nootropic Agents Phase 1
27
Cocaine Approved, Illicit 50-36-2 5760 446220
28
Calcium carbonate Approved, Investigational 471-34-1
29 Tomato Approved
30
Dopamine Approved 51-61-6, 62-31-7 681
31
Acetylcholine Approved, Investigational 51-84-3 187
32
Methamphetamine Approved, Illicit 537-46-2 10836
33 Ophthalmic Solutions
34 Dopamine Agents
35 abobotulinumtoxinA
36 Botulinum Toxins, Type A
37 Botulinum Toxins
38 Vaccines
39 Dopamine Uptake Inhibitors
40 Adrenergic Agents
41 Sympathomimetics

Interventional clinical trials:

(show top 50) (show all 119)
# Name Status NCT ID Phase Drugs
1 The Effect of Donepezil on Perceptual Learning in Adult Amblyopia Completed NCT03109314 Phase 4 Donepezil
2 A Randomized Trial Comparing Daily Atropine Versus Weekend Atropine Completed NCT00094614 Phase 4 Atropine
3 Vision In Preschoolers Study (VIP Study) Unknown status NCT00038753 Phase 3
4 A Randomized Trial Comparing Near Versus Distance Activities While Patching for Amblyopia in Children 3 to <7 Years Old Completed NCT00315198 Phase 3
5 Amblyopia Treatment Study: Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia Completed NCT00000170 Phase 3 Atropine
6 A Randomized Trial of Full-time Bangerter Filters Versus Part-time Daily Patching for the Treatment of Moderate Amblyopia in Children Completed NCT00525174 Phase 3
7 Increasing Patching for Amblyopia in Children 3 to < 8 Years Old Completed NCT00945100 Phase 3
8 Anisometropia Amblyopia Improved by Perceptual Learning and Patching Completed NCT00498641 Phase 3
9 Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old Completed NCT00944710 Phase 3 Atropine;Atropine
10 A Randomized Trial of Levodopa as Treatment for Residual Amblyopia (ATS 17) Completed NCT01190813 Phase 3 Levodopa/Carbidopa;Placebo
11 Amblyopia Treatment Study Completed NCT00001864 Phase 3 Atropine
12 A Randomized Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds Completed NCT00315328 Phase 3 Atropine
13 Electronic Recording of Compliance With Occlusion Therapy for Amblyopia: 1 Effects of Patient Education on Compliance 2 Predictors for Non-Compliance Completed NCT00131729 Phase 3
14 A Randomized Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye As Prescribed Treatments for Amblyopia in Children 3 to <7 Years Old Completed NCT00315302 Phase 3 Atropine
15 A Randomized Trial Comparing Part-time Versus Full-time Patching for Severe Amblyopia Completed NCT00094744 Phase 3
16 An Evaluation of Treatment of Amblyopia in 7 To <18 Year Olds Completed NCT00094692 Phase 3 atropine
17 A Randomized Trial Comparing Part-time Versus Minimal-time Patching for Moderate Amblyopia Completed NCT00094679 Phase 3
18 A Randomized Trial to Evaluate 2 Hours of Daily Patching for Amblyopia in Children 3 to <7 Years Old Completed NCT00091923 Phase 3
19 A Prospective, Multicenter, Randomized, Masked, Controlled Pivotal Trial to Assess the Safety and Effectiveness of an Eye-Tracking-Based Treatment for Amblyopia Under Binocular Conditions Versus the Standard of Care, Monocular Deprivation Treatment (Occlusive Patching) Not yet recruiting NCT04785690 Phase 3
20 A Randomized Trial to Evaluate Combined Patching-Atropine for Residual Amblyopia Terminated NCT00506675 Phase 3 Atropine;Atropine
21 A Randomized Trial Comparing Patching With Active Vision Therapy to Patching With Control Vision Therapy as Treatment for Amblyopia in Children 7 to <13 Years Old Terminated NCT00587171 Phase 3
22 Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia? Completed NCT01308307 Phase 2
23 A Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia in 8 to 17 Year Olds Completed NCT00789672 Phase 2 levodopa/carbidopa;levodopa/carbidopa
24 Evaluation and Development of a Novel Binocular Treatment (I-BiTTM) System Using Video Clips and Interactive Games to Improve Vision in Children With Amblyopia ('Lazy Eye'). Completed NCT01702727 Phase 2
25 Effectiveness of Telescopic Magnification in the Treatment of Amblyopia Completed NCT00970554 Phase 1, Phase 2
26 Comparison of Photorefraction With Cycloautorefraction and Cycloretinoscopy at Emam Hosein Medical Centre in 2008-2009 Completed NCT00815581 Phase 1, Phase 2
27 Pilot Study to Evaluate Docosahexaenoic Acid as Treatment for Residual Amblyopia Not yet recruiting NCT03402789 Phase 1, Phase 2 Docosahexaenoic Acid;Placebo Oral Tablet
28 Caffeine in Amblyopia Study Withdrawn NCT02594358 Phase 1, Phase 2 Caffeine
29 Randomised Occlusion Treatment of Amblyopia Study (ROTAS): Trial of Maximal Vs Substantial Doses of Occlusion to Evaluate Visual Outcome for Children With Amblyopia Completed NCT00274664 Phase 1
30 A Randomized, Three-Sequence, Three-Period Crossover Study to Assess the Bioavailability and Pharmacokinetics of a Single Dose of Atropine Administered Sublingually in Healthy Adult Volunteers Completed NCT04290039 Phase 1 Atropine Sulfate Ophthalmic Solution;Atropine Sulphate Injection
31 Investigation of Visual Plasticity by a Direct Current Stimulation of Occipital Cortex in Adult Amblyopia Completed NCT00097162 Phase 1
32 Recovery From Amblyopia With Cholinesterase Inhibitors Recruiting NCT01584076 Phase 1 Donepezil
33 A 52 Week Randomized, Single-masked, Multicenter Proof of Concept Study of Binocular Videogames Versus Patching for Amblyopia in Children 4-7 Years of Age With an Open-label Substudy of Binocular Videogames in Children 8-12 Years of Age Not yet recruiting NCT04784390 Phase 1
34 Dichoptic Virtual Reality Therapy for Amblyopia in Adults Terminated NCT02246556 Phase 1
35 Efficacy and Safety of Eyetronix Flicker Glasses to the Treatment of Anisometropic Amblyopia in Chinese Children Unknown status NCT02970708
36 The Use of Interactive Binocular Treatment (I-BiT) for the Management of Anisometropic, Strabismic and Mixed Amblyopia in Children Aged 3.5 - 12 Years Unknown status NCT02810847
37 Visual Functional Connectivity and Visual Function in Amblyopia Before and After TMS and/or Binocular Treatment Unknown status NCT03151200
38 The Role of Interactive Binocular Treatment System in Amblyopia Therapy Unknown status NCT02740725
39 A Randomised Clinical Trial Objectively Comparing the Effect of Patching Therapy With Video Gaming for Amblyopia Unknown status NCT03767985
40 Intense vs Standard Regimens of Intermittent Occlusion Therapy for Unilateral Moderate Amblyopia in Children Unknown status NCT02767856
41 Efficacy of Intermittent Occlusion Therapy Glasses for Amblyopia Unknown status NCT02687581
42 Determining the Efficacy of Full-time Occlusion Therapy in Severe Amblyopia at All Ages Unknown status NCT02113709
43 A Comparative Study Between Dissociative Treatment and Binocular Interactive Treatment in Amblyopia Unknown status NCT03255707
44 Early Vision Screening With Automated Photorefraction in Pre-term, Low-birth- Weight and Development-delay Children in Far-Eastern Memorial Hospital, Taiwan Unknown status NCT02678468
45 MRI-based Biomarkers for the Prognosis Judgement of Punctate White Matter Lesions in Neonates: a Longitudinal Multicenter Study Unknown status NCT02637817
46 Vision Screening of the Four Year Old Children for the Detection of Amblyopia in The Town of Zagreb Completed NCT01430247
47 Will Perceptual Learning Via Video Game Playing Improve Visual Acuity, Stereopsis and Fixation Stability in Mild Amblyopes? Part 2 Study Completed NCT02995174
48 Bilateral Refractive Amblyopia Treatment Study Completed NCT00305955
49 An Observational Study of Optical Correction for Strabismic Amblyopia in Children 3 to <7 Years Old Completed NCT00669539
50 Refractive and Strabismic Amblyopia Risk Factors Detected by Infrared Photoscreener and School Bus Skiascopy Completed NCT03668067

Search NIH Clinical Center for Suppression Amblyopia

Cochrane evidence based reviews: amblyopia

Sources

Genetic Tests for Suppression Amblyopia

About this section
Sources

Anatomical Context for Suppression Amblyopia

About this section

MalaCards organs/tissues related to Suppression Amblyopia:

40
Eye, Cortex, Brain, Retina, Endothelial, Pituitary, Thalamus
Sources

Publications for Suppression Amblyopia

About this section

Articles related to Suppression Amblyopia:

(show top 50) (show all 7395)
# Title Authors PMID Year
1
Characterising the orientation-specific pattern-onset visual evoked potentials in children with bilateral refractive amblyopia and non-amblyopic controls. 61
32968834 2021
2
Corrigendum to "l-Dopa methyl ester attenuates amblyopia-induced neuronal injury in visual cortex of amblyopic cat" [Gene 527 (2013) 115-122]. 61
33581886 2021
3
Increased Incidence of Ophthalmologic Findings in Children With Concurrent Isolated Nonsyndromic Metopic Suture Abnormalities and Deformational Cranial Vault Asymmetry. 61
32929979 2021
4
Vision Needs of Children Who Failed School-based Vision Screening with and without Eyeglasses. 61
32752905 2021
5
Motor Competence in Children With and Without Ambliopia. 61
33435851 2021
6
Descemet Membrane Endothelial Keratoplasty in Congenital Hereditary Endothelial Dystrophy: Initial Experiences. 61
33734164 2021
7
Ocular manifestations in kabuki syndrome: A report of 10 cases and literature review. 61
33334222 2021
8
Ocular manifestations and surgical interventions in pediatric patients with Koolen-de-Vries syndrome. 61
33393407 2021
9
Prevalence and causes of bilateral visual impairment in rural areas of Tianjin, China - The Tianjin Eye Study. 61
32602247 2021
10
Clinical spectrum and treatment outcomes of patients with nanophthalmos. 61
32461562 2021
11
A toric rigid bifocal contact lens for a presbyopic patient with corneal astigmatism and amblyopia. 61
33689659 2021
12
Brown syndrome: clinical features and results of superior oblique tenotomy. 61
33567010 2021
13
Trametinib for orbital plexiform neurofibromas in young children with neurofibromatosis type 1. 61
33751171 2021
14
Is hypermetropia regressing in accommodative esotropia? 61
33567009 2021
15
The effects of amblyopia on children's reading performance after patching treatment. 61
33653149 2021
16
Adherence to home-based videogame treatment for amblyopia in children and adults. 61
33689654 2021
17
Alternative Flicker Glass: a New Anti-suppression Approach to the Treatment of Anisometropic Amblyopia. 61
33652438 2021
18
Fixation Characteristics of Severe Amblyopia with Eccentric Fixation and Central Fixation Assessed by the MP-1 Microperimeter. 61
33661718 2021
19
Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses. 61
33783486 2021
20
Efficacy of Perceptual Learning-Based Vision Training as an Adjuvant to Occlusion Therapy in the Management of Amblyopia: A Pilot Study. 61
33807038 2021
21
Effectiveness of the Spot Vision Screener in screening 3-year-old children with potential amblyopia in Japan. 61
33646435 2021
22
A New Zealand kaka with amblyopia - does the parrot need a pirate patch? 61
33689649 2021
23
Emerging therapies for amblyopia. 61
33656963 2021
24
Scope and costs of autorefraction and photoscreening for childhood amblyopia-a systematic narrative review in relation to the EUSCREEN project data. 61
33257800 2021
25
Presentation, surgery and 1-year outcomes of childhood cataract surgery in Tanzania. 61
32522793 2021
26
Associations between visual function and magnitude of refractive error for emmetropic to moderately hyperopic 4- and 5-year-old children in the Vision in Preschoolers - Hyperopia in Preschoolers Study. 61
33772848 2021
27
[Prevalence of visual impairment in school-age children: Data analysis from PlanVue® pilot project]. 61
33494974 2021
28
Current landscape of Oculocutaneous Albinism in Japan. 61
32969595 2021
29
Treatment of congenital and early childhood cataract. 61
33783620 2021
30
Binocular summation is affected by crowding and tagging. 61
33649371 2021
31
Reduced visual acuity in children from 5 to 6 years old, with LEA chart. 61
32945936 2021
32
Severe hypercalcemia in an infant with unbalanced translocation of chromosomes 2 and 8: a possible contribution of 2p duplication. 61
33662191 2021
33
2020 Evaluation of Portable Vision Screening Instruments. 61
33795987 2021
34
Long-term ophthalmic outcomes in 120 children with unilateral coronal synostosis: a 20-year retrospective analysis. 61
33716150 2021
35
Contributing ocular comorbidity to end-of-life visual acuity in medically treated glaucoma patients, ocular hypertension and glaucoma suspect patients. 61
32494040 2021
36
The Genetic and Clinical Features of FOXL2-Related Blepharophimosis, Ptosis and Epicanthus Inversus Syndrome. 61
33806295 2021
37
Ocular coloboma-a comprehensive review for the clinician. 61
33746210 2021
38
Clinical assessment and FGFR2 mutation analysis in a Chinese family with Crouzon syndrome: A case report. 61
33725872 2021
39
Choroidal thickness and ocular growth in childhood. 61
32634443 2021
40
A smartphone ocular alignment measurement app in school screening for strabismus. 61
33765984 2021
41
The Flash-lag Effect in Amblyopia. 61
33599734 2021
42
Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia. 61
33542265 2021
43
Knowledge and attitudes regarding amblyopia among parents in Jeddah, Saudi Arabia: a cross-sectional study. 61
33568219 2021
44
Long-term follow-up of an amblyopia treatment study: change in visual acuity 15 years after occlusion therapy. 61
32657530 2021
45
Neural correlates of visual spatial selective attention are altered at early and late processing stages in human amblyopia. 61
33107117 2021
46
The use of atropine for treatment of amblyopia using the OptumLabs Data Warehouse. 61
33348039 2021
47
Predicting Risk Factors for Consecutive Esotropia Failed with Conservative Therapy. 61
33587682 2021
48
Cost-effectiveness analysis of preloaded versus non-preloaded Descemet membrane endothelial keratoplasty for the treatment of Fuchs endothelial corneal dystrophy in an academic centre. 61
33637619 2021
49
Progression From Soft Lens to Piggyback Soft-Scleral Contact Lens System to Facilitate Scleral Lens Use in a Pediatric Patient. 61
33605634 2021
50
Ocular biometric measurements and optical coherence tomography parameters in children with refractive errors and emmetropia. 61
33463576 2021
Sources

Variations for Suppression Amblyopia

About this section
Sources

Expression for Suppression Amblyopia

About this section
Search GEO for disease gene expression data for Suppression Amblyopia.
Sources

Pathways for Suppression Amblyopia

About this section
Sources

GO Terms for Suppression Amblyopia

About this section

Biological processes related to Suppression Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of signaling receptor activity GO:2000272 8.96 MTRNR2L5 MTRNR2L4
2 negative regulation of execution phase of apoptosis GO:1900118 8.62 MTRNR2L5 MTRNR2L4

Molecular functions related to Suppression Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor antagonist activity GO:0048019 8.62 MTRNR2L5 MTRNR2L4
Sources

Sources for Suppression Amblyopia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....