Aliases & Classifications for Suppression Amblyopia

MalaCards integrated aliases for Suppression Amblyopia:

Name: Suppression Amblyopia 12 15
Amblyopia 44 72
Amblyopia, Suppression 72
Strabismic Amblyopia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10375
ICD9CM 35 368.01
MeSH 44 D000550
SNOMED-CT 68 35600002
ICD10 33 H53.03
UMLS 72 C0002418 C0750903

Summaries for Suppression Amblyopia

MalaCards based summary : Suppression Amblyopia, also known as amblyopia, is related to amblyopia and disuse amblyopia, and has symptoms including photophobia, other specified visual disturbances and visual disturbance. An important gene associated with Suppression Amblyopia is SIRPA (Signal Regulatory Protein Alpha). The drugs Tropicamide and Atropine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex, and related phenotype is Increased shRNA abundance.

Related Diseases for Suppression Amblyopia

Diseases related to Suppression Amblyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 amblyopia 30.0 SIRPA DPT
2 disuse amblyopia 12.5
3 mental and growth retardation with amblyopia 12.2
4 microphthalmia, isolated 6 11.6
5 farsightedness 11.6
6 astigmatism 11.6
7 duane retraction syndrome 1 11.6
8 peters-plus syndrome 11.4
9 hemifacial hyperplasia with strabismus 11.4
10 isolated ectopia lentis 11.4
11 paralytic squint 11.4
12 blepharophimosis, ptosis, and epicanthus inversus 11.2
13 duane retraction syndrome 2 11.2
14 corneal dystrophy, congenital stromal 11.2
15 bestrophinopathy, autosomal recessive 11.2
16 cerulean cataract 11.2
17 aniridia 1 11.1
18 aniridia and absent patella 11.1
19 cataract 41 11.1
20 fibrosis of extraocular muscles, congenital, 1 11.1
21 bornholm eye disease 11.1
22 fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement 11.1
23 mental retardation, anterior maxillary protrusion, and strabismus 11.1
24 cognitive impairment with or without cerebellar ataxia 11.1
25 duane retraction syndrome 3 with or without deafness 11.1
26 aniridia 2 11.1
27 duane syndrome type 2 11.1
28 hivep2-related intellectual disability 11.1
29 isolated duane retraction syndrome 11.1
30 monocular esotropia 10.8
31 esotropia 10.8
32 anisometropia 10.7
33 ptosis 10.6
34 refractive error 10.6
35 eye disease 10.6
36 pathologic nystagmus 10.5
37 ocular dominance 10.5
38 congenital ptosis 10.5
39 hemangioma 10.4
40 microvascular complications of diabetes 5 10.4
41 alternating exotropia 10.4
42 exotropia 10.4
43 scotoma 10.4
44 47,xyy 10.4
45 lacrimal duct defect 10.3
46 optic nerve disease 10.3
47 intraocular pressure quantitative trait locus 10.2
48 achromatopsia 10.2
49 3-methylglutaconic aciduria, type iii 10.2
50 macular degeneration, age-related, 1 10.2

Graphical network of the top 20 diseases related to Suppression Amblyopia:



Diseases related to Suppression Amblyopia

Symptoms & Phenotypes for Suppression Amblyopia

UMLS symptoms related to Suppression Amblyopia:


photophobia, other specified visual disturbances, visual disturbance

GenomeRNAi Phenotypes related to Suppression Amblyopia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.62 APTX GRM6

Drugs & Therapeutics for Suppression Amblyopia

Drugs for Suppression Amblyopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tropicamide Approved, Investigational Phase 4 1508-75-4 5593
2
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
3
Donepezil Approved Phase 4 120014-06-4 3152
4
Brinzolamide Approved Phase 4 138890-62-7 68844
5
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
6
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
7
Cefpirome Approved Phase 4 84957-29-9 5479539
8
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
9
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
10
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
11
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
12
Polyestradiol phosphate Approved Phase 4 28014-46-2
13
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
14 Mydriatics Phase 4
15 Parasympatholytics Phase 4
16 Adjuvants, Anesthesia Phase 4
17 Cholinergic Antagonists Phase 4
18 Muscarinic Antagonists Phase 4
19 Respiratory System Agents Phase 4
20 Anti-Asthmatic Agents Phase 4
21 Bronchodilator Agents Phase 4
22 Nootropic Agents Phase 4
23 Cholinesterase Inhibitors Phase 4
24 Ophthalmic Solutions Phase 4
25 Anti-Inflammatory Agents Phase 4
26 Carbonic Anhydrase Inhibitors Phase 4
27 Analgesics Phase 4
28 Cyclooxygenase Inhibitors Phase 4
29 Analgesics, Non-Narcotic Phase 4
30 Anti-Inflammatory Agents, Non-Steroidal Phase 4
31 Ketorolac Tromethamine Phase 4
32 Antirheumatic Agents Phase 4
33 Contraceptives, Oral Phase 4
34 Contraceptive Agents Phase 4
35 Contraceptives, Oral, Combined Phase 4
36 Norgestimate, ethinyl estradiol drug combination Phase 4
37 Anti-Bacterial Agents Phase 4
38 Cephalosporins Phase 4
39 Anti-Infective Agents Phase 4
40 Antibiotics, Antitubercular Phase 4
41 Topoisomerase Inhibitors Phase 4
42 Estradiol 3-benzoate Phase 4
43 Estradiol 17 beta-cypionate Phase 4
44 Peripheral Nervous System Agents Phase 4
45 Autonomic Agents Phase 4
46 Sodium Channel Blockers Phase 4
47 Diuretics, Potassium Sparing Phase 4
48 Sympatholytics Phase 4
49
Levodopa Approved Phase 3 59-92-7 6047
50
Carbidopa Approved Phase 3 28860-95-9 34359

Interventional clinical trials:

(show top 50) (show all 145)
# Name Status NCT ID Phase Drugs
1 Pilot Study of Prevention Myopia in Children With Low Concentration of Atropine Unknown status NCT00541177 Phase 4 atropine;tropicamide
2 The Effect of Donepezil on Perceptual Learning in Adult Amblyopia Completed NCT03109314 Phase 4 Donepezil
3 A Randomized Trial Comparing Daily Atropine Versus Weekend Atropine Completed NCT00094614 Phase 4 Atropine
4 Topical Brinzolamide Ophthalmic Suspension Versus Placebo in the Treatment of Infantile Nystagmus Syndrome Completed NCT01312402 Phase 4 topical brinzolamide 1% in 5mL ophthalmic medication;Placebo in 5 mL dispenser
5 Mini-flared Kelman Tip and Reverse Tip With Torsional Phaco: Prospective Randomized Comparative Study Completed NCT02089698 Phase 4
6 Comparison of Ketorolac Tromethamine 0.4% and Nepafenac 0.1% for the Prevention of Cystoid Macular Edema After Phacoemulsification: Prospective Randomized Double-masked Study Completed NCT02084576 Phase 4 Nepafenac;Ketorolac
7 Plasma and Abscess Fluid Pharmacokinetics of Cefpirome and Moxifloxacin After Single and Multiple Dose Administration Completed NCT00280514 Phase 4 cefpirome and moxifloxacin administration
8 A Pilot and Feasibility Study to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Recruiting NCT02347111 Phase 4 Flecainide;Sotalol
9 Topical Timolol for the Treatment of Benign Vascular Periocular Lesions Withdrawn NCT01250457 Phase 4 topical Timolol
10 Clinical Evaluation of the Use of Sealed Capsule Irrigation With Sodium Chloride During Pediatric Cataract Surgery and IOL Implantation Withdrawn NCT00366613 Phase 4
11 Vision In Preschoolers Study (VIP Study) Unknown status NCT00038753 Phase 3
12 Anisometropia Amblyopia Improved by Perceptual Learning and Patching Completed NCT00498641 Phase 3
13 A Randomized Trial of Levodopa as Treatment for Residual Amblyopia (ATS 17) Completed NCT01190813 Phase 3 Levodopa/Carbidopa;Placebo
14 A Randomized Trial Comparing Part-time Versus Minimal-time Patching for Moderate Amblyopia Completed NCT00094679 Phase 3
15 Increasing Patching for Amblyopia in Children 3 to < 8 Years Old Completed NCT00945100 Phase 3
16 A Randomized Trial Comparing Near Versus Distance Activities While Patching for Amblyopia in Children 3 to <7 Years Old Completed NCT00315198 Phase 3
17 A Randomized Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye As Prescribed Treatments for Amblyopia in Children 3 to <7 Years Old Completed NCT00315302 Phase 3 Atropine
18 A Randomized Trial Comparing Part-time Versus Full-time Patching for Severe Amblyopia Completed NCT00094744 Phase 3
19 Electronic Recording of Compliance With Occlusion Therapy for Amblyopia: 1 Effects of Patient Education on Compliance 2 Predictors for Non-Compliance Completed NCT00131729 Phase 3
20 Amblyopia Treatment Study: Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia Completed NCT00000170 Phase 3 Atropine
21 Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old Completed NCT00944710 Phase 3 Atropine;Atropine
22 An Evaluation of Treatment of Amblyopia in 7 To <18 Year Olds Completed NCT00094692 Phase 3 atropine
23 Amblyopia Treatment Study Completed NCT00001864 Phase 3 Atropine
24 A Randomized Trial to Evaluate 2 Hours of Daily Patching for Amblyopia in Children 3 to <7 Years Old Completed NCT00091923 Phase 3
25 A Randomized Trial of Full-time Bangerter Filters Versus Part-time Daily Patching for the Treatment of Moderate Amblyopia in Children Completed NCT00525174 Phase 3
26 A Randomized Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds Completed NCT00315328 Phase 3 Atropine
27 Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity Completed NCT01203436 Phase 2, Phase 3
28 A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
29 A Randomized Trial Comparing Patching With Active Vision Therapy to Patching With Control Vision Therapy as Treatment for Amblyopia in Children 7 to <13 Years Old Terminated NCT00587171 Phase 3
30 A Randomized Trial to Evaluate Combined Patching-Atropine for Residual Amblyopia Terminated NCT00506675 Phase 3 Atropine;Atropine
31 A Novel Therapeutic Strategy Targeting Photoreceptor Oxidative Damage in ABCR-related Retinal Degenerations Unknown status NCT01278277 Phase 1, Phase 2
32 Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia? Completed NCT01308307 Phase 2
33 A Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia in 8 to 17 Year Olds Completed NCT00789672 Phase 2 levodopa/carbidopa;levodopa/carbidopa
34 Effectiveness of Telescopic Magnification in the Treatment of Amblyopia Completed NCT00970554 Phase 1, Phase 2
35 Evaluation and Development of a Novel Binocular Treatment (I-BiTTM) System Using Video Clips and Interactive Games to Improve Vision in Children With Amblyopia ('Lazy Eye'). Completed NCT01702727 Phase 2
36 Comparison of Photorefraction With Cycloautorefraction and Cycloretinoscopy at Emam Hosein Medical Centre in 2008-2009 Completed NCT00815581 Phase 1, Phase 2
37 Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants Completed NCT00349726 Phase 2 Inositol lower volume;Inositol higher volume;Placebo lower volume;Placebo higher volume
38 Phase II Randomized, Double-Masked, Placebo-Controlled, Safety, Pharmacokinetic, and Dose-Ranging Study of Multiple Doses of Inositol in Premature Infants Completed NCT01030575 Phase 2 Inositol lower volume;Inositol mid-level volume;Inositol high volume;Placebo low volume
39 THOR - Tübingen Choroideremia Gene Therapy Trial Open Label Phase 2 Clinical Trial Using an Adeno-associated Viral Vector (AAV2) Encoding Rab-escort Protein 1 (REP1) Active, not recruiting NCT02671539 Phase 2
40 Pilot Study to Evaluate Docosahexaenoic Acid as Treatment for Residual Amblyopia Not yet recruiting NCT03402789 Phase 1, Phase 2 Docosahexaenoic Acid;Placebo Oral Tablet
41 Caffeine in Amblyopia Study Withdrawn NCT02594358 Phase 1, Phase 2 Caffeine
42 Randomised Occlusion Treatment of Amblyopia Study (ROTAS): Trial of Maximal Vs Substantial Doses of Occlusion to Evaluate Visual Outcome for Children With Amblyopia Completed NCT00274664 Phase 1
43 Investigation of Visual Plasticity by a Direct Current Stimulation of Occipital Cortex in Adult Amblyopia Completed NCT00097162 Phase 1
44 A Singapore Pilot Study To Evaluate The Efficacy Of A Computerized System For The Vision Improvement Of People With Low Myopia Completed NCT00348127 Phase 1
45 Monovision for Treatment of Diplopia Completed NCT01426672 Phase 1
46 Pilot Study To Evaluate The Efficacy Of Neurovision'S NVC™- Vision Correction Technology For The Improvement In Visual Acuity In Myopic Children And Slowing Down Of Myopia Progression Completed NCT00348218 Phase 1
47 Recovery From Amblyopia With Cholinesterase Inhibitors Recruiting NCT01584076 Phase 1 Donepezil
48 Dichoptic Virtual Reality Therapy for Amblyopia in Adults Terminated NCT02246556 Phase 1
49 Phase 1 Study of Topical Beta Blocker to Prevent the Proliferative Stage of Infantile Hemangioma Terminated NCT01434849 Phase 1 topical 0.5% Timolol maleate;Control (placebo) group
50 Early Vision Screening With Automated Photorefraction in Pre-term, Low-birth- Weight and Development-delay Children in Far-Eastern Memorial Hospital, Taiwan Unknown status NCT02678468

Search NIH Clinical Center for Suppression Amblyopia

Cochrane evidence based reviews: amblyopia

Genetic Tests for Suppression Amblyopia

Anatomical Context for Suppression Amblyopia

MalaCards organs/tissues related to Suppression Amblyopia:

41
Eye, Testes, Cortex, Brain, Retina, Endothelial, Pituitary

Publications for Suppression Amblyopia

Articles related to Suppression Amblyopia:

(show top 50) (show all 6917)
# Title Authors PMID Year
1
tDCS recovers depth perception in adult amblyopic rats and reorganizes visual cortex activity. 38
31078617 2019
2
Bilateral Congenital Corneal Opacities as an Early-Onset Ocular Feature of Kabuki Syndrome. 38
30950893 2019
3
Simplified updates on the pathophysiology and recent developments in the treatment of amblyopia: A review. 38
31436180 2019
4
Biometry: a tool for the detection of amblyopia risk factor in children. 38
31183540 2019
5
[An investigation on professional performance of optometric refraction in spectacles stores in Anyang city of Henan Province]. 38
31422635 2019
6
Analysis of Choroidal Vascularity in Children with Unilateral Hyperopic Amblyopia. 38
31434959 2019
7
Amblyopia Affects the ON Visual Pathway More than the OFF. 38
31189574 2019
8
Effects of Temporal Frequency on Binocular Deficits in Amblyopia. 38
31404553 2019
9
Morphologic changes in the visual cortex of patients with anisometropic amblyopia: a surface-based morphometry study. 38
31375091 2019
10
Analysis of Macular Vessel Density and Foveal Avascular Zone in Adults with Amblyopia. 38
31283893 2019
11
Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens. 38
31429729 2019
12
Comparison of amblyopia in schoolchildren in Ireland and Northern Ireland: a population-based observational cross-sectional analysis of a treatable childhood visual deficit. 38
31401612 2019
13
Factors determining the outcome of paediatric exotropia surgery. 38
31424031 2019
14
Study on the High Functional Contact Lens Material with Superior Oxygen Transmissibility and Antibacterial Properties. 38
30913731 2019
15
Ocular dominance plasticity: A binocular combination task finds no cumulative effect with repeated patching. 38
31194984 2019
16
Novel BRPF1 mutation in a boy with intellectual disability, coloboma, facial nerve palsy and hypoplasia of the corpus callosum. 38
31176769 2019
17
Cost-Effectiveness of Limited Vitrectomy for Vision-Degrading Myodesopsia. 38
30849342 2019
18
Assessment of stereovision with digital testing in adults and children with normal and impaired binocularity. 38
31377344 2019
19
[Orbital Disorders in Childhood]. 38
31412385 2019
20
Impaired Fellow Eye Motion Perception and Abnormal Binocular Function. 38
31387113 2019
21
Referral for Ophthalmology Evaluation and Visual Sequelae in Children With Primary Brain Tumors. 38
31373649 2019
22
Foveal avascular zone and macular vessel density after correction for magnification error in unilateral amblyopia using optical coherence tomography angiography. 38
31382925 2019
23
Prevalence of anterior polar cataracts in children and risk factors for amblyopia. 38
30390373 2019
24
The effect of asymmetrical accommodation on anisometropic amblyopia treatment outcomes. 38
31301347 2019
25
Video interpretation and diagnosis of pediatric amblyopia and eye disease. 38
31364472 2019
26
Regression of fetal vasculature and visual improvement in nonsurgical persistent hyperplastic primary vitreous: a case report. 38
31349817 2019
27
The Outcome of Scleral Lens Fitting for Keratoconus With Resolved Corneal Hydrops. 38
31170103 2019
28
Fellow Eye Deficits in Amblyopia. 38
31161888 2019
29
A Convenient and Robust Test to Quantify Interocular Suppression for Children With Amblyopia. 38
31384415 2019
30
Amblyopia treatment and quality of life: the child's perspective on atropine versus patching. 38
31329017 2019
31
Feasibility of monitoring compliance with intermittent occlusion therapy glasses for amblyopia treatment. 38
31271842 2019
32
Analysis of retinal nerve fiber layer thickness in anisometropic amblyopia via optic coherence tomography. 38
31270595 2019
33
Dichoptic De-Masking Learning in Adults With Amblyopia and Its Mechanisms. 38
31307059 2019
34
Optical Coherence Tomography normative peripapillary retinal nerve fiber layer and macular data in children ages 0-5 years. 38
31271744 2019
35
Sex-specific difference in age distribution of congenital lower eyelid epiblepharon in a Japanese population. 38
31286315 2019
36
Defining outcome measures in juvenile idiopathic arthritis associated uveitis by a systematic review analysis: do we need a consensus? 38
31296236 2019
37
Oral fluoxetine in the management of amblyopic patients aged between 10 and 40 years old: a randomized clinical trial. 38
30783259 2019
38
Visual Acuity and Ophthalmic Outcomes in the Year After Cataract Surgery Among Children Younger Than 13 Years. 38
31095258 2019
39
Analysis of macular, foveal, and retinal nerve fiber layer thickness in children with unilateral anisometropic amblyopia and their changes following occlusion therapy. 38
31238399 2019
40
Commentary: Analysis of macular, foveal and retinal nerve fiber layer thickness in children with unilateral anisometropic amblyopia and their changes following occlusion therapy. 38
31238400 2019
41
Comparison of higher order aberrations in amblyopic and non-amblyopic eyes in pediatric patients with anisometropic amblyopia. 38
31238401 2019
42
Binocular game versus part-time patching for treatment of anisometropic amblyopia in Chinese children: a randomised clinical trial. 38
31272953 2019
43
Don't Miss This! Red Flags in the Pediatric Eye Examination: Subnormal Acuity. 38
31329058 2019
44
OCT angiography of persistent hyaloid artery: a case report. 38
31272412 2019
45
A commonly occurring genetic variant within the NPLOC4-TSPAN10-PDE6G gene cluster is associated with the risk of strabismus. 38
31073882 2019
46
Comparative study of visual dysfunctions in 6-10-year-old very preterm- and full-term-born children. 38
29916121 2019
47
Expanding the phenotypic spectrum of MBOAT7-related intellectual disability. 38
31282596 2019
48
Tribal Odisha Eye Disease Study (TOES) report # 5: Comparison of prevalence and causes of visual impairment among tribal children in native and urban schools of Odisha (India). 38
31238398 2019
49
Visual outcome and surgical results in children with Marfan syndrome. 38
31325202 2019
50
Clinical investigation plan for the use of interactive binocular treatment (I-BiT) for the management of anisometropic, strabismic and mixed amblyopia in children aged 3.5-12 years: a randomised controlled trial. 38
31311577 2019

Variations for Suppression Amblyopia

Expression for Suppression Amblyopia

Search GEO for disease gene expression data for Suppression Amblyopia.

Pathways for Suppression Amblyopia

GO Terms for Suppression Amblyopia

Sources for Suppression Amblyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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