Aliases & Classifications for Suppression Amblyopia

MalaCards integrated aliases for Suppression Amblyopia:

Name: Suppression Amblyopia 12 15
Amblyopia 43 71
Amblyopia, Suppression 71
Strabismic Amblyopia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10375
ICD9CM 34 368.01
MeSH 43 D000550
SNOMED-CT 67 35600002
ICD10 32 H53.03
UMLS 71 C0002418 C0750903

Summaries for Suppression Amblyopia

MalaCards based summary : Suppression Amblyopia, also known as amblyopia, is related to paralytic squint and astigmatism, and has symptoms including photophobia, other specified visual disturbances and visual disturbance. An important gene associated with Suppression Amblyopia is PLAAT3 (Phospholipase A And Acyltransferase 3). The drugs Tropicamide and Atropine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex.

Related Diseases for Suppression Amblyopia

Diseases related to Suppression Amblyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 paralytic squint 31.9 PLAAT3 PHOX2A MTRNR2L5
2 astigmatism 31.5 DSE DPT
3 accommodative esotropia 30.6 PLAAT3 PHOX2A
4 hypotropia 30.4 PLAAT3 PHOX2A
5 monofixation syndrome 30.3 TNFRSF10C PLAAT3
6 congenital ptosis 30.2 PHOX2A DPT
7 ocular motility disease 30.2 PLAAT3 PHOX2A
8 esotropia 30.0 PLAAT3 PHOX2A DSE DPT
9 anisometropia 30.0 TNFRSF10C PLAAT3 DSE DPT
10 exotropia 29.9 PLAAT3 PHOX2A DPT
11 cycloplegia 29.8 DSE DPT
12 aniseikonia 29.6 PLAAT3 DSE DPT
13 facial paralysis 29.5 MTRNR2L5 MTRNR2L4
14 hypertropia 29.5 PLAAT3 PHOX2A DPT
15 strabismus 28.5 TNFRSF10C PLAAT3 PHOX2A DSE DPT
16 amblyopia 28.5 TNFRSF10C SIRPA PLAAT3 PHOX2A HNMT DSE
17 ametropic amblyopia 28.4 PHOX2A MTRNR2L5 MTRNR2L4 DSE DPT
18 disuse amblyopia 12.5
19 mental and growth retardation with amblyopia 12.2
20 microphthalmia, isolated 6 11.6
21 farsightedness 11.6
22 duane retraction syndrome 1 11.5
23 peters-plus syndrome 11.4
24 hemifacial hyperplasia with strabismus 11.4
25 isolated ectopia lentis 11.4
26 microphthalmia 11.4
27 blepharophimosis, ptosis, and epicanthus inversus 11.2
28 duane retraction syndrome 2 11.2
29 corneal dystrophy, congenital stromal 11.2
30 bestrophinopathy, autosomal recessive 11.2
31 cerulean cataract 11.2
32 aniridia 1 11.1
33 aniridia and absent patella 11.1
34 cataract 41 11.1
35 fibrosis of extraocular muscles, congenital, 1 11.1
36 bornholm eye disease 11.1
37 fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement 11.1
38 mental retardation, anterior maxillary protrusion, and strabismus 11.1
39 cognitive impairment with or without cerebellar ataxia 11.1
40 duane retraction syndrome 3 with or without deafness 11.1
41 aniridia 2 11.1
42 catifa syndrome 11.1
43 cataract microcornea syndrome 11.1
44 hivep2-related intellectual disability 11.1
45 isolated duane retraction syndrome 11.1
46 monocular esotropia 10.8
47 ptosis 10.6
48 refractive error 10.6
49 eye disease 10.6
50 pathologic nystagmus 10.6

Graphical network of the top 20 diseases related to Suppression Amblyopia:



Diseases related to Suppression Amblyopia

Symptoms & Phenotypes for Suppression Amblyopia

UMLS symptoms related to Suppression Amblyopia:


photophobia, other specified visual disturbances, visual disturbance

Drugs & Therapeutics for Suppression Amblyopia

Drugs for Suppression Amblyopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tropicamide Approved, Investigational Phase 4 1508-75-4 5593
2
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
3
Donepezil Approved Phase 4 120014-06-4 3152
4
Brinzolamide Approved Phase 4 138890-62-7 68844
5
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
6
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
7
Cefpirome Approved Phase 4 84957-29-9 5479539
8
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
9
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
10
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
11
Polyestradiol phosphate Approved Phase 4 28014-46-2
12
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
13
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
14 Mydriatics Phase 4
15 Adjuvants, Anesthesia Phase 4
16 Anti-Asthmatic Agents Phase 4
17 Respiratory System Agents Phase 4
18 Muscarinic Antagonists Phase 4
19 Bronchodilator Agents Phase 4
20 Cholinergic Antagonists Phase 4
21 Parasympatholytics Phase 4
22 Nootropic Agents Phase 4
23 Cholinesterase Inhibitors Phase 4
24 Ophthalmic Solutions Phase 4
25 Anti-Inflammatory Agents Phase 4
26 Carbonic Anhydrase Inhibitors Phase 4
27 Anti-Inflammatory Agents, Non-Steroidal Phase 4
28 Analgesics, Non-Narcotic Phase 4
29 Cyclooxygenase Inhibitors Phase 4
30 Ketorolac Tromethamine Phase 4
31 Antirheumatic Agents Phase 4
32 Analgesics Phase 4
33 Anti-Infective Agents Phase 4
34 Cephalosporins Phase 4
35 Contraceptive Agents Phase 4
36 Norgestimate, ethinyl estradiol drug combination Phase 4
37 Estradiol 17 beta-cypionate Phase 4
38 Antibiotics, Antitubercular Phase 4
39 Contraceptives, Oral, Combined Phase 4
40 Anti-Bacterial Agents Phase 4
41 Topoisomerase Inhibitors Phase 4
42 Contraceptives, Oral Phase 4
43 Estradiol 3-benzoate Phase 4
44 Autonomic Agents Phase 4
45 Sodium Channel Blockers Phase 4
46 Diuretics, Potassium Sparing Phase 4
47 Sympatholytics Phase 4
48
Levodopa Approved Phase 3 59-92-7 6047
49
Carbidopa Approved Phase 3 28860-95-9 34359
50
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983

Interventional clinical trials:

(show top 50) (show all 154)
# Name Status NCT ID Phase Drugs
1 Pilot Study of Prevention Myopia in Children With Low Concentration of Atropine Unknown status NCT00541177 Phase 4 atropine;tropicamide
2 The Effect of Donepezil on Perceptual Learning in Adult Amblyopia Completed NCT03109314 Phase 4 Donepezil
3 A Randomized Trial Comparing Daily Atropine Versus Weekend Atropine Completed NCT00094614 Phase 4 Atropine
4 Mini-flared Kelman Tip and Reverse Tip With Torsional Phaco: Prospective Randomized Comparative Study Completed NCT02089698 Phase 4
5 Topical Brinzolamide Ophthalmic Suspension Versus Placebo in the Treatment of Infantile Nystagmus Syndrome Completed NCT01312402 Phase 4 topical brinzolamide 1% in 5mL ophthalmic medication;Placebo in 5 mL dispenser
6 Comparison of Ketorolac Tromethamine 0.4% and Nepafenac 0.1% for the Prevention of Cystoid Macular Edema After Phacoemulsification: Prospective Randomized Double-masked Study Completed NCT02084576 Phase 4 Nepafenac;Ketorolac
7 Plasma and Abscess Fluid Pharmacokinetics of Cefpirome and Moxifloxacin After Single and Multiple Dose Administration Completed NCT00280514 Phase 4 cefpirome and moxifloxacin administration
8 A Pilot and Feasibility Study to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Recruiting NCT02347111 Phase 4 Flecainide;Sotalol
9 Topical Timolol for the Treatment of Benign Vascular Periocular Lesions Withdrawn NCT01250457 Phase 4 topical Timolol
10 Clinical Evaluation of the Use of Sealed Capsule Irrigation With Sodium Chloride During Pediatric Cataract Surgery and IOL Implantation Withdrawn NCT00366613 Phase 4
11 Vision In Preschoolers Study (VIP Study) Unknown status NCT00038753 Phase 3
12 Anisometropia Amblyopia Improved by Perceptual Learning and Patching Completed NCT00498641 Phase 3
13 A Randomized Trial of Levodopa as Treatment for Residual Amblyopia (ATS 17) Completed NCT01190813 Phase 3 Levodopa/Carbidopa;Placebo
14 A Randomized Trial Comparing Part-time Versus Minimal-time Patching for Moderate Amblyopia Completed NCT00094679 Phase 3
15 Increasing Patching for Amblyopia in Children 3 to < 8 Years Old Completed NCT00945100 Phase 3
16 A Randomized Trial Comparing Near Versus Distance Activities While Patching for Amblyopia in Children 3 to <7 Years Old Completed NCT00315198 Phase 3
17 A Randomized Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye As Prescribed Treatments for Amblyopia in Children 3 to <7 Years Old Completed NCT00315302 Phase 3 Atropine
18 A Randomized Trial Comparing Part-time Versus Full-time Patching for Severe Amblyopia Completed NCT00094744 Phase 3
19 Amblyopia Treatment Study: Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia Completed NCT00000170 Phase 3 Atropine
20 Electronic Recording of Compliance With Occlusion Therapy for Amblyopia: 1 Effects of Patient Education on Compliance 2 Predictors for Non-Compliance Completed NCT00131729 Phase 3
21 Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old Completed NCT00944710 Phase 3 Atropine;Atropine
22 An Evaluation of Treatment of Amblyopia in 7 To <18 Year Olds Completed NCT00094692 Phase 3 atropine
23 Amblyopia Treatment Study Completed NCT00001864 Phase 3 Atropine
24 A Randomized Trial of Full-time Bangerter Filters Versus Part-time Daily Patching for the Treatment of Moderate Amblyopia in Children Completed NCT00525174 Phase 3
25 A Randomized Trial to Evaluate 2 Hours of Daily Patching for Amblyopia in Children 3 to <7 Years Old Completed NCT00091923 Phase 3
26 A Randomized Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds Completed NCT00315328 Phase 3 Atropine
27 Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity Completed NCT01203436 Phase 2, Phase 3
28 A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
29 A Randomized Trial Comparing Patching With Active Vision Therapy to Patching With Control Vision Therapy as Treatment for Amblyopia in Children 7 to <13 Years Old Terminated NCT00587171 Phase 3
30 A Randomized Trial to Evaluate Combined Patching-Atropine for Residual Amblyopia Terminated NCT00506675 Phase 3 Atropine;Atropine
31 A Novel Therapeutic Strategy Targeting Photoreceptor Oxidative Damage in ABCR-related Retinal Degenerations Unknown status NCT01278277 Phase 1, Phase 2
32 Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia? Completed NCT01308307 Phase 2
33 A Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia in 8 to 17 Year Olds Completed NCT00789672 Phase 2 levodopa/carbidopa;levodopa/carbidopa
34 Effectiveness of Telescopic Magnification in the Treatment of Amblyopia Completed NCT00970554 Phase 1, Phase 2
35 Evaluation and Development of a Novel Binocular Treatment (I-BiTTM) System Using Video Clips and Interactive Games to Improve Vision in Children With Amblyopia ('Lazy Eye'). Completed NCT01702727 Phase 2
36 Comparison of Photorefraction With Cycloautorefraction and Cycloretinoscopy at Emam Hosein Medical Centre in 2008-2009 Completed NCT00815581 Phase 1, Phase 2
37 Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants Completed NCT00349726 Phase 2 Inositol lower volume;Inositol higher volume;Placebo lower volume;Placebo higher volume
38 Phase II Randomized, Double-Masked, Placebo-Controlled, Safety, Pharmacokinetic, and Dose-Ranging Study of Multiple Doses of Inositol in Premature Infants Completed NCT01030575 Phase 2 Inositol lower volume;Inositol mid-level volume;Inositol high volume;Placebo low volume
39 THOR - Tübingen Choroideremia Gene Therapy Trial Open Label Phase 2 Clinical Trial Using an Adeno-associated Viral Vector (AAV2) Encoding Rab-escort Protein 1 (REP1) Active, not recruiting NCT02671539 Phase 2
40 Pilot Study to Evaluate Docosahexaenoic Acid as Treatment for Residual Amblyopia Not yet recruiting NCT03402789 Phase 1, Phase 2 Docosahexaenoic Acid;Placebo Oral Tablet
41 Caffeine in Amblyopia Study Withdrawn NCT02594358 Phase 1, Phase 2 Caffeine
42 Randomised Occlusion Treatment of Amblyopia Study (ROTAS): Trial of Maximal Vs Substantial Doses of Occlusion to Evaluate Visual Outcome for Children With Amblyopia Completed NCT00274664 Phase 1
43 Investigation of Visual Plasticity by a Direct Current Stimulation of Occipital Cortex in Adult Amblyopia Completed NCT00097162 Phase 1
44 A Singapore Pilot Study To Evaluate The Efficacy Of A Computerized System For The Vision Improvement Of People With Low Myopia Completed NCT00348127 Phase 1
45 Monovision for Treatment of Diplopia Completed NCT01426672 Phase 1
46 Pilot Study To Evaluate The Efficacy Of Neurovision'S NVC™- Vision Correction Technology For The Improvement In Visual Acuity In Myopic Children And Slowing Down Of Myopia Progression Completed NCT00348218 Phase 1
47 Recovery From Amblyopia With Cholinesterase Inhibitors Recruiting NCT01584076 Phase 1 Donepezil
48 Dichoptic Virtual Reality Therapy for Amblyopia in Adults Terminated NCT02246556 Phase 1
49 Phase 1 Study of Topical Beta Blocker to Prevent the Proliferative Stage of Infantile Hemangioma Terminated NCT01434849 Phase 1 topical 0.5% Timolol maleate;Control (placebo) group
50 Early Vision Screening With Automated Photorefraction in Pre-term, Low-birth- Weight and Development-delay Children in Far-Eastern Memorial Hospital, Taiwan Unknown status NCT02678468

Search NIH Clinical Center for Suppression Amblyopia

Cochrane evidence based reviews: amblyopia

Genetic Tests for Suppression Amblyopia

Anatomical Context for Suppression Amblyopia

MalaCards organs/tissues related to Suppression Amblyopia:

40
Eye, Testes, Cortex, Brain, Retina, Endothelial, Pituitary

Publications for Suppression Amblyopia

Articles related to Suppression Amblyopia:

(show top 50) (show all 7035)
# Title Authors PMID Year
1
Smartphone use in ophthalmology: What is their place in clinical practice? 61
31541618 2020
2
Visual Outcomes in Presumed Congenital Foveal Toxoplasmosis. 61
32035830 2020
3
Colour vision testing in young children with reduced visual acuity. 61
31469512 2020
4
Spontaneous regression of congenital corneal opacity. 61
31768679 2020
5
Visual improvement in amblyopic eye following treatment-induced vision loss in dominant eye with uveal melanoma. 61
31097438 2020
6
Outcomes of surgery in patients with sensory exotropia. 61
31836297 2020
7
Plusoptix photoscreener use for paediatric vision screening in Flanders and Iran. 61
31197950 2020
8
National consensus statement regarding pediatric eye examination, refraction, and amblyopia management. 61
31957721 2020
9
Refractive Errors and Amblyopia Among Children Screened by the UCLA Preschool Vision Program in Los Angeles County. 61
31647932 2020
10
Binocular Treatment of Amblyopia: A Report by the American Academy of Ophthalmology. 61
31619356 2020
11
Effectiveness of combined dichoptic therapy, binocular vision therapy, and part-time patching for the management of amblyopia in adults. 61
31856546 2020
12
Stereoacuity Improvement using Random-Dot Video Games. 61
32009644 2020
13
Anterior lamellar keratoplasty for the management of a central dermoid tumour in a baby. 61
31735598 2020
14
Amblyopia Risk Factors in Newborns With Congenital Nasolacrimal Duct Obstruction. 61
31972039 2020
15
Sensory Eye Dominance: Relationship Between Eye and Brain. 61
32021530 2020
16
Long-term Monocular Deprivation during Juvenile Critical Period Disrupts Binocular Integration in Mouse Visual Thalamus. 61
31767678 2020
17
Two-Year Outcomes of Infants with Stage 2 or Higher Retinopathy of Prematurity: Results from a Large Multicenter Registry. 61
31480086 2020
18
Comparison of photoscreening and autorefractive screening for the detection of amblyopia risk factors in children under 3 years of age. 61
31926368 2020
19
Positive predictive value and screening performance of GoCheck Kids in a primary care university clinic. 61
31940501 2020
20
Comparison of Retinal Vascular Structure in Eyes With and Without Amblyopia by Optical Coherence Tomography Angiography. 61
31972041 2020
21
Ophthalmic Pathology in the Offspring of Pregnant Women with Gestational Diabetes Mellitus. 61
31997119 2020
22
Effectiveness of the iPhone GoCheck Kids smartphone vision screener in detecting amblyopia risk factors. 61
31904429 2020
23
Surgical Intervention of Periocular Infantile Hemangiomas in the Era of β-Blockers. 61
31809485 2020
24
Severe reverse amblyopia with atropine penalization. 61
31953022 2020
25
Multifocal electroretinography in amblyopia. 61
31900648 2020
26
[An amblyopia revealing extended fibers in myelin]. 61
31973974 2020
27
Systematic Evaluation of Levodopa Effect on Visual Improvement in Amblyopia: A Meta-analysis. 61
31738189 2020
28
Infantile simple dacryops: clinicopathological correlation and immunocharacterization. 61
31821863 2019
29
[Vision screening in children: Review of the literature]. 61
31733915 2019
30
Quality of life and mental health in amblyopic children treated with and without occlusion therapy. 61
31678257 2019
31
Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex. 61
31868167 2019
32
The impact of vision screening in preschool children on visual function in the Swedish adult population. 61
31127702 2019
33
Evaluation of Pupillary Light Reflex in Amblyopic Eyes Using Dynamic Pupillometry 61
31893585 2019
34
Children with congenital and childhood cataract require frequent follow-up visits and examinations in general anaesthesia: considerations for the strain on families. 61
30860655 2019
35
Optical Coherence Tomography Normative Peripapillary Retinal Nerve Fiber Layer and Macular Data in Children 0-5 Years of Age. 61
31271744 2019
36
Current Management of Childhood Amblyopia. 61
31833253 2019
37
Visual outcome and surgical results in children with Marfan syndrome. 61
31325202 2019
38
Associations between Attention-Deficit/Hyperactivity Disorder and Ocular Abnormalities in Children: A Population-based Study. 61
31878821 2019
39
Brain abnormalities in infantile esotropia as predictor for consecutive exotropia. 61
31637944 2019
40
Strabismus Patterns in Patients with Intrauterine Drug Exposure. 61
31852370 2019
41
Accuracy of online health information on amblyopia and strabismus. 61
31610240 2019
42
Investigation of Stress and Distress Experienced by Guardians of Children with Strabismus and/or Amblyopia. 61
31858895 2019
43
The Danish Rural Eye Study: prevalence of strabismus among 3785 Danish adults - a population-based cross-sectional study. 61
31025814 2019
44
[Do children with strabismus receive ophthalmic treatment? : Results from the KiGGS (German Health Interview and Examination Survey for Children and Adolescents) baseline survey (2003-2006)]. 61
30980175 2019
45
Long-term visual outcomes following abusive head trauma with retinal hemorrhage. 61
31655114 2019
46
Posterior microphthalmos with good visual acuity: A case report. 61
31763497 2019
47
Altered functional interactions between neurons in primary visual cortex of macaque monkeys with experimental amblyopia. 61
31553685 2019
48
Ophthalmologic disorders and risk factors in children with autism spectrum disorder. 61
31676470 2019
49
Amblyopia: Detection and Treatment. 61
31845774 2019
50
Non-invasive current stimulation in vision recovery: a review of the literature. 61
31884495 2019

Variations for Suppression Amblyopia

Expression for Suppression Amblyopia

Search GEO for disease gene expression data for Suppression Amblyopia.

Pathways for Suppression Amblyopia

GO Terms for Suppression Amblyopia

Biological processes related to Suppression Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to glucocorticoid GO:0051384 9.16 HSD11B2 HNMT
2 negative regulation of signaling receptor activity GO:2000272 8.96 MTRNR2L5 MTRNR2L4
3 negative regulation of execution phase of apoptosis GO:1900118 8.62 MTRNR2L5 MTRNR2L4

Molecular functions related to Suppression Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor antagonist activity GO:0048019 8.96 MTRNR2L5 MTRNR2L4
2 cell-cell adhesion mediator activity GO:0098632 8.62 SIRPA MYPN

Sources for Suppression Amblyopia

3 CDC
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28 GO
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32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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