MCID: SPP004
MIFTS: 32

Suppurative Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Suppurative Cholangitis

MalaCards integrated aliases for Suppurative Cholangitis:

Name: Suppurative Cholangitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14269
ICD10 33 K83.0
NCIt 50 C35336
SNOMED-CT 68 197437002 69850007
UMLS 73 C0267924

Summaries for Suppurative Cholangitis

MalaCards based summary : Suppurative Cholangitis is related to cholangitis and sclerosing cholangitis. An important gene associated with Suppurative Cholangitis is TREM1 (Triggering Receptor Expressed On Myeloid Cells 1), and among its related pathways/superpathways are Innate Immune System and amb2 Integrin signaling. Affiliated tissues include liver, myeloid and kidney, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Suppurative Cholangitis

Diseases related to Suppurative Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 cholangitis 30.9 ABCB4 CRP DLAT TNF
2 sclerosing cholangitis 29.4 ABCB4 MPO TNF
3 orbital melanoma 10.9 CANX TAPBP
4 maxillary sinus squamous cell carcinoma 10.6 CANX TAPBP
5 mucinous intrahepatic cholangiocarcinoma 10.6 CDX2 MUC2
6 acute cholangitis 10.4 CRP TREM1
7 staphylococcal toxic shock syndrome 10.3 HMGB1 TNF
8 ovarian mucinous adenocarcinoma 10.2 CDX2 MUC2
9 voyeurism 10.2 SLC4A4 SLC4A8
10 hypersensitivity reaction disease 10.2 CDSN DLAT TNF
11 mononeuritis of upper limb and mononeuritis multiplex 10.2 CDSN MPO
12 cholangitis, primary sclerosing 10.2 ABCB4 DLAT MPO
13 toxic shock syndrome 10.1 HMGB1 TNF TREM1
14 transvestism 10.1 SLC4A4 SLC4A8
15 fetishism 10.1 SLC4A4 SLC4A8
16 myeloperoxidase deficiency 10.1 CANX MPO
17 carotid stenosis 10.1 CRP TNF TREM1
18 spondyloarthropathy 1 10.0 CRP TAPBP TNF
19 autoimmune inner ear disease 10.0 MPO TNF
20 trench fever 10.0 TNF TRIM33
21 hepatitis 10.0
22 aortitis 10.0 CRP MPO
23 microscopic polyangiitis 9.9 MPO TNF
24 choledocholithiasis 9.9
25 cholecystitis 9.9
26 pancreatitis 9.9
27 mononeuritis multiplex 9.9 CDSN CRP MPO
28 chronic cholangitis 9.8 CDX2 MUC2
29 mouth disease 9.8 CRP HMGB1 TNF
30 rheumatic disease 9.8 CRP HMGB1 TNF
31 agammaglobulinemia, x-linked 9.8
32 aging 9.8
33 hepatitis b 9.8
34 liver cirrhosis 9.8
35 inflammatory bowel disease 9.8
36 cholelithiasis 9.8
37 cholera 9.8
38 agammaglobulinemia 9.8
39 hyperglycemia 9.8
40 amyloidosis 9.8
41 al amyloidosis 9.8
42 aneurysm 9.8
43 secondary sclerosing cholangitis 9.8
44 anca-associated vasculitis 9.7 HMGB1 MPO TNF
45 mediastinitis 9.6 CRP MPO
46 pleural disease 9.6 CRP MPO TNF
47 proctitis 9.6 CRP MPO TNF
48 pleurisy 9.6 CRP MPO TNF
49 appendicitis 9.6 CRP MPO TNF
50 autoinflammation, lipodystrophy, and dermatosis syndrome 9.6 CRP MPO TNF

Graphical network of the top 20 diseases related to Suppurative Cholangitis:



Diseases related to Suppurative Cholangitis

Symptoms & Phenotypes for Suppurative Cholangitis

MGI Mouse Phenotypes related to Suppurative Cholangitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 ABCB4 ACTB CDKN1A CDX2 CRP FOXO3
2 hematopoietic system MP:0005397 10.03 SLC4A4 SULT1E1 TAPBP TNF TREM1 S1PR2
3 homeostasis/metabolism MP:0005376 10 ABCB4 ACTB CDKN1A CDX2 CRP FOXO3
4 digestive/alimentary MP:0005381 9.97 ABCB4 CDKN1A CDX2 FOXO3 MUC2 SLC4A4
5 endocrine/exocrine gland MP:0005379 9.97 ABCB4 ACTB CDKN1A CDX2 FOXO3 MUC2
6 immune system MP:0005387 9.8 TRIM33 ABCB4 ACTB CANX CDKN1A CRP
7 neoplasm MP:0002006 9.32 ABCB4 ACTB CDKN1A CDX2 FOXO3 MUC2

Drugs & Therapeutics for Suppurative Cholangitis

Search Clinical Trials , NIH Clinical Center for Suppurative Cholangitis

Genetic Tests for Suppurative Cholangitis

Anatomical Context for Suppurative Cholangitis

MalaCards organs/tissues related to Suppurative Cholangitis:

41
Liver, Myeloid, Kidney

Publications for Suppurative Cholangitis

Articles related to Suppurative Cholangitis:

(show top 50) (show all 82)
# Title Authors Year
1
Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia. ( 28856582 )
2017
2
Acute suppurative cholangitis due to an impacted pancreatic stone: a rare adverse event in the setting of chronic calcifiedA pancreatitis. ( 28842170 )
2017
3
Changes of Foxo3a in PBMCs and its associations with stress hyperglycemia in acute obstructive suppurative cholangitis patients. ( 29100348 )
2017
4
Safety of immediate endoscopic sphincterotomy in acute suppurative cholangitis caused by choledocholithiasis. ( 26862368 )
2016
5
Urgent endoscopic ultrasound-guided choledochoduodenostomy for acute obstructive suppurative cholangitis-induced sepsis. ( 27122677 )
2016
6
Risk Factors for Death of Elderly Patients with Acute Obstructive Suppurative Cholangitis. ( 26716798 )
2015
7
Role of high-mobility group box 1 in patients with acute obstructive suppurative cholangitis-induced sepsis. ( 25792849 )
2015
8
Suppurative cholangitis induced by a fully covered self-expandable metal stent covering cystic stumps in a post-liver transplant patient. ( 24193943 )
2013
9
AL amyloidosis with severe gastrointestinal invasion and acute obstructive suppurative cholangitis. ( 21643678 )
2012
10
Endoscopic nasobiliary drainage and percutaneous transhepatic biliary drainage for the treatment of acute obstructive suppurative cholangitis: a retrospective study of 37 cases. ( 22591676 )
2012
11
Acute obstructive suppurative cholangitis as a cause of acute kidney injury and rhabdomyolysis. ( 21707899 )
2011
12
What are the risk factors for acute suppurative cholangitis caused by common bile duct stones? ( 20981214 )
2010
13
Is nasobiliary drainage unnecessary for drainage of acute suppurative cholangitis? Our experience. ( 20590759 )
2010
14
Clinical determinants of suppurative cholangitis in malignant biliary tract obstruction. ( 20635678 )
2010
15
Discrimination of suppurative cholangitis from nonsuppurative cholangitis with computed tomography (CT). ( 18191523 )
2009
16
Cholangiographic features of suppurative cholangitis. ( 19058801 )
2009
17
[Expression of human triggering receptor expressed on myeloid cells 1 in peripheral blood mononuclear cells of patients with acute obstructive suppurative cholangitis]. ( 19923060 )
2009
18
The safety and effectiveness of endoscopic biliary decompression by plastic stent placement in acute suppurative cholangitis compared with nasobiliary drainage. ( 18635173 )
2008
19
Risk factors for acute suppurative cholangitis caused by bile duct stones. ( 17556906 )
2007
20
Rupture of a pancreaticoduodenal artery aneurysm into the common bile duct resulting in fatal suppurative cholangitis: report of a case. ( 15622474 )
2005
21
Non-calculus suppurative cholangitis in Danish patients with inflammatory bowel disease. ( 15783009 )
2005
22
Does the addition of endoscopic sphincterotomy to stent insertion improve drainage of the bile duct in acute suppurative cholangitis? ( 14520292 )
2003
23
Does the addition of endoscopic sphincterotomy to stent insertion improve drainage of the bile duct in acute suppurative cholangitis? ( 14520280 )
2003
24
Aeromonas veronii biovar veronii septicaemia and acute suppurative cholangitis in a patient with hepatitis B. ( 12867570 )
2003
25
Biliary decompression by nasobiliary catheter or biliary stent in acute suppurative cholangitis: a prospective randomized trial. ( 12196773 )
2002
26
Rapid progress of acute suppurative cholangitis to secondary sclerosing cholangitis sequentially followed-up by endoscopic retrograde cholangiography. ( 11473338 )
2001
27
Endoscopic removal of Ascaris lumbricoides from the biliary tract as emergency treatment for acute suppurative cholangitis. ( 11558071 )
2001
28
Aeromonas infection in acute suppurative cholangitis: review of 30 cases. ( 10762115 )
2000
29
Intravenous ciprofloxacin as treatment for patients with acute suppurative cholangitis: a randomized, controlled clinical trial. ( 7559196 )
1995
30
Treatment of choice for choledocholithiasis in patients with acute obstructive suppurative cholangitis and liver cirrhosis. ( 7573728 )
1995
31
Acute suppurative cholangitis associated with choledochal sludge. ( 8147369 )
1994
32
Endoscopic nasobiliary drainage in acute suppurative cholangitis. ( 8076986 )
1994
33
Endoscopic nasobiliary drainage for acute suppurative cholangitis: a sonographically guided method. ( 8495839 )
1993
34
Emergency endoscopic nasobiliary drainage for acute calculous suppurative cholangitis and its potential use in chemical dissolution. ( 8439660 )
1993
35
Sonographic detection of hepatic portal venous gas associated with suppurative cholangitis. ( 8514901 )
1993
36
Risk factors and classification of acute suppurative cholangitis. ( 1643478 )
1992
37
Duodenoscopic sphincterotomy for acute suppurative cholangitis. ( 2490941 )
1989
38
Urgent endoscopic drainage for acute suppurative cholangitis. ( 2566834 )
1989
39
Bacteriological study of choledochal bile in patients with common bile duct stones, with or without acute suppurative cholangitis. ( 2502489 )
1989
40
A case report of acute obstructive suppurative cholangitis in a non-0-1 Vibrio cholerae biliary carrier. ( 2802912 )
1989
41
Histological analysis of liver parenchyma and choledochal wall, and external diameter and intraluminal pressure of the common bile duct in controls and patients with common bile duct stones with and without acute suppurative cholangitis. ( 2753460 )
1989
42
Endoscopic drainage for suppurative cholangitis. ( 2568534 )
1989
43
Common bile duct pressure in patients with common bile duct stones with or without acute suppurative cholangitis. ( 3369934 )
1988
44
Isolation of Vibrio fluvialis, and unusual pathogen in acute suppurative cholangitis. ( 3631041 )
1987
45
Ultrasonography of acute obstructive suppurative cholangitis: serial observation by ultrasound. ( 3106424 )
1987
46
Percutaneous biliary drainage in acute suppurative cholangitis. ( 3943682 )
1986
47
Animal model of suppurative cholangitis and bilirubin cholangiolithiasis. ( 3089705 )
1986
48
CT detection of portal venous gas associated with suppurative cholangitis and cholecystitis. ( 3876731 )
1985
49
Acute obstructive suppurative cholangitis. ( 6366490 )
1984
50
The significance of nonvisualization of extrahepatic bile duct in intravenous radionuclide cholescintigraphy with special reference to acute suppurative cholangitis. ( 6467762 )
1984

Variations for Suppurative Cholangitis

Expression for Suppurative Cholangitis

Search GEO for disease gene expression data for Suppurative Cholangitis.

Pathways for Suppurative Cholangitis

Pathways related to Suppurative Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 ACTB CANX CDKN1A CRP FOXO3 HMGB1
2 10.48 HMGB1 MPO TNF
3 10.36 MPO TNF

GO Terms for Suppurative Cholangitis

Biological processes related to Suppurative Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to organic substance GO:0010033 9.58 ABCB4 CDKN1A TNF
2 negative regulation of growth of symbiont in host GO:0044130 9.37 MPO TNF
3 response to dexamethasone GO:0071548 9.32 ABCB4 FOXO3
4 positive regulation of programmed cell death GO:0043068 9.26 CDKN1A TNF
5 negative regulation of lipid storage GO:0010888 9.16 CRP TNF
6 response to glucocorticoid GO:0051384 9.13 CDKN1A HMGB1 TNF
7 protein kinase B signaling GO:0043491 8.8 CDKN1A FOXO3 TNF

Molecular functions related to Suppurative Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anion transmembrane transporter activity GO:0008509 8.96 SLC4A4 SLC4A8
2 sodium:bicarbonate symporter activity GO:0008510 8.62 SLC4A4 SLC4A8

Sources for Suppurative Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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