MCID: SPP004
MIFTS: 28

Suppurative Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Suppurative Cholangitis

MalaCards integrated aliases for Suppurative Cholangitis:

Name: Suppurative Cholangitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:14269
NCIt 49 C35336
SNOMED-CT 67 69850007
ICD10 32 K83.0
UMLS 71 C0267924

Summaries for Suppurative Cholangitis

MalaCards based summary : Suppurative Cholangitis is related to cholangitis and cholelithiasis. An important gene associated with Suppurative Cholangitis is TREM1 (Triggering Receptor Expressed On Myeloid Cells 1). The drugs Furosemide and Kava have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and colon.

Related Diseases for Suppurative Cholangitis

Diseases related to Suppurative Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 cholangitis 31.2 GPT DLAT CRP ABCB4
2 cholelithiasis 30.2 GPT CRP ABCB4
3 acute cholangitis 29.3 TREM1 GPT GGTLC3 GGT2 CRP
4 choledocholithiasis 29.3 GPT GGTLC3 GGT2 CRP ABCB4
5 primary biliary cirrhosis 29.2 SEPSECS GPT DLAT ABCB4
6 biliary tract disease 28.5 GPT GGTLC3 GGT2 DLAT CRP ABCB4
7 chronic cholangitis 10.4 DLAT ABCB4
8 parenteral nutrition-associated cholestasis 10.4 GPT ABCB4
9 obstructive jaundice 10.3
10 cholecystitis 10.3
11 extrahepatic cholestasis 10.2 GPT ABCB4
12 gallbladder disease 1 10.2
13 chondromalacia 10.2 TREM1 CRP
14 emphysematous cholecystitis 10.2 GPT CRP
15 cataract 14, multiple types 10.2 SLC4A8 SLC4A4
16 tinea unguium 10.2 GPT CRP
17 splenic abscess 10.2 GPT CRP
18 acalculous cholecystitis 10.2 GPT CRP
19 granulomatous hepatitis 10.2 GPT CRP
20 gastrointestinal tuberculosis 10.2 GPT CRP
21 cholestasis 10.2
22 toxic shock syndrome 10.2
23 heart aneurysm 10.2 GPT CRP
24 hydrops of gallbladder 10.2 GPT CRP
25 paralytic ileus 10.2 GPT CRP
26 coronary aneurysm 10.2 GPT CRP
27 splenic infarction 10.1 GPT CRP
28 pyuria 10.1 GPT CRP
29 large intestine lipoma 10.1 GPT CRP
30 kwashiorkor 10.1 GPT CRP
31 lipoma of colon 10.1 GPT CRP
32 analbuminemia 10.1 GPT CRP
33 volvulus of midgut 10.1 GPT CRP
34 relapsing polychondritis 10.1 TREM1 CRP
35 intestinal perforation 10.1 GPT CRP
36 nasopharyngitis 10.1 GPT CRP
37 pharyngitis 10.1 GPT CRP
38 drug allergy 10.1 GPT CRP
39 ocular motor apraxia 10.1
40 cholangiocarcinoma 10.1
41 intrahepatic cholangiocarcinoma 10.1
42 liver cirrhosis 10.1
43 alexithymia 10.1 CRP ABCB4
44 compartment syndrome 10.1 GPT CRP
45 cecal disease 10.1 GPT CRP
46 bronchopneumonia 10.1 GPT CRP
47 aspiration pneumonia 10.0 GPT CRP
48 functional gastric disease 10.0 GPT CRP
49 pericardium disease 10.0 GPT CRP
50 bile duct rhabdomyosarcoma 10.0 GGTLC3 GGT2

Graphical network of the top 20 diseases related to Suppurative Cholangitis:



Diseases related to Suppurative Cholangitis

Symptoms & Phenotypes for Suppurative Cholangitis

Drugs & Therapeutics for Suppurative Cholangitis

Drugs for Suppurative Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Furosemide Approved, Vet_approved Phase 2 54-31-9 3440
2 Kava Approved, Investigational, Nutraceutical Phase 2 9000-38-8
3 diuretics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Randomized Trial Comparing Short-term Stenting Versus Balloon Dilatation for Dominant Strictures in Primary Sclerosing Cholangitis Unknown status NCT01398917 Phase 3
2 MANAGEMENT OF THE PATIENT WITH ACUTE ABDOMEN SUBMITTED TO URGENT ABDOMINAL SURGERY: a Pilot Randomized Multicentre Study Completed NCT01911702 Phase 2

Search NIH Clinical Center for Suppurative Cholangitis

Genetic Tests for Suppurative Cholangitis

Anatomical Context for Suppurative Cholangitis

MalaCards organs/tissues related to Suppurative Cholangitis:

40
Liver, Pancreas, Colon, Kidney, Salivary Gland, Myeloid, Neutrophil

Publications for Suppurative Cholangitis

Articles related to Suppurative Cholangitis:

(show top 50) (show all 276)
# Title Authors PMID Year
1
Cumbersome removal of an endoscopic nasobiliary drainage tube. 61
31215215 2019
2
Simplified scoring system for prediction of mortality in acute suppurative cholangitis. 61
30063015 2018
3
[The Management of Common Bile Duct Stones]. 61
29791984 2018
4
Acute suppurative cholangitis due to an impacted pancreatic stone: a rare adverse event in the setting of chronic calcified pancreatitis. 61
28842170 2018
5
Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia. 61
28856582 2017
6
Changes of Foxo3a in PBMCs and its associations with stress hyperglycemia in acute obstructive suppurative cholangitis patients. 61
29100348 2017
7
Intraoperative endoscopic nasobiliary drainage over primary closure of the common bile duct for choledocholithiasis combined with cholecystolithiasis: a cohort study of 211 cases. 61
27864721 2017
8
Successful Removal of a Large Common Bile Duct Stone by Using Direct Peroral Cholangioscopy and Laser Lithotripsy in a Patient with Severe Kyphosis. 61
27000425 2016
9
Urgent endoscopic ultrasound-guided choledochoduodenostomy for acute obstructive suppurative cholangitis-induced sepsis. 61
27122677 2016
10
Safety of immediate endoscopic sphincterotomy in acute suppurative cholangitis caused by choledocholithiasis. 61
26862368 2016
11
[Serum and bile cytokines dynamics in patients with non-tumoral obstructive jaundice and suppurative cholangitis]. 61
27239909 2016
12
[The value of volatile fatty acids, citrulline and malondialdehyde for diagnosis of suppurative cholangitis in obstructive jaundice and choosing of optimal surgical approach (with commentary)]. 61
27804933 2016
13
Risk Factors for Death of Elderly Patients with Acute Obstructive Suppurative Cholangitis. 61
26716798 2015
14
[Application of hepatic segment resection combined with rigid choledochoscope in the treatment of complex hepatolithiasis guided by three-dimensional visualization technology]. 61
26082246 2015
15
[Prevention and treatment of complications for full-covered self-expanding removable metal stents in malignant obstructive jaundice]. 61
25916776 2015
16
Mouse models of primary biliary cirrhosis. 61
25777756 2015
17
The role of endoscopy in the management of recurrent pyogenic cholangitis: a review. 61
26333855 2015
18
Role of high-mobility group box 1 in patients with acute obstructive suppurative cholangitis-induced sepsis. 61
25792849 2015
19
Anatomic resection of liver segments 6-8 for hepatocellular carcinoma. 61
24764684 2014
20
Laparoendoscopic approach for refractory Roux-en-Y hepaticojejunostomy stricture in an acute setting: a unique case and technique. 61
24450348 2014
21
Autoimmune features in metabolic liver disease: a single-center experience and review of the literature. 61
23842720 2013
22
Minimally invasive treatment of cholecysto-choledocal lithiasis: The point of view of the surgical endoscopist. 61
23977417 2013
23
[A case of so-called carcinosarcoma of the middle portion of the bile duct diagnosed preoperatively]. 61
23381215 2013
24
Role of AE2 for pHi regulation in biliary epithelial cells. 61
24478713 2013
25
Suppurative cholangitis induced by a fully covered self-expandable metal stent covering cystic stumps in a post-liver transplant patient. 61
24193943 2013
26
Risk factors and incidence of acute pyogenic cholangitis. 61
23232638 2012
27
Endoscopic nasobiliary drainage and percutaneous transhepatic biliary drainage for the treatment of acute obstructive suppurative cholangitis: a retrospective study of 37 cases. 61
22591676 2012
28
Endoscopic retrograde appendicitis therapy: a pilot minimally invasive technique (with videos). 61
22840292 2012
29
Percutaneous transhepatic metallic stent insertion for malignant afferent loop obstruction following pancreaticoduodenectomy: a case report. 61
22800503 2012
30
AL amyloidosis with severe gastrointestinal invasion and acute obstructive suppurative cholangitis. 61
21643678 2012
31
Approaches to the pathogenesis of primary biliary cirrhosis through animal models. 61
21862437 2012
32
Severe sepsis caused by Aeromonas hydrophila in a patient using tocilizumab: a case report. 61
21970314 2011
33
Acute obstructive suppurative cholangitis as a cause of acute kidney injury and rhabdomyolysis. 61
21707899 2011
34
The role of the pathologist in diagnosing and grading biliary diseases. 61
21474418 2011
35
Charcot's triad. 61
21584209 2011
36
What are the risk factors for acute suppurative cholangitis caused by common bile duct stones? 61
20981214 2010
37
Is nasobiliary drainage unnecessary for drainage of acute suppurative cholangitis? Our experience. 61
20590759 2010
38
Case review of impacted bile duct stone at duodenal papilla: detection and endoscopic treatment. 61
20499418 2010
39
Clinical determinants of suppurative cholangitis in malignant biliary tract obstruction. 61
20635678 2010
40
Two-stage treatment of an unusual haemobilia caused by intrahepatic pseudoaneurysm. 61
21160957 2010
41
Application of endoscopic retrograde cholangiopancreatography in biliary-pancreatic diseases. 61
20137483 2009
42
[Expression of human triggering receptor expressed on myeloid cells 1 in peripheral blood mononuclear cells of patients with acute obstructive suppurative cholangitis]. 61
19923060 2009
43
Endoscopic biliary drainage for choledocholithiasis in a patient with aplastic anemia before hematological engraftment after allogeneic transplantation. 61
19483403 2009
44
Discrimination of suppurative cholangitis from nonsuppurative cholangitis with computed tomography (CT). 61
18191523 2009
45
Cholangiographic features of suppurative cholangitis. 61
19058801 2009
46
Abscess of the round ligament of the liver associated with acute obstructive cholangitis and septic thrombosis. 61
19881239 2009
47
[Oncologic emergency in the abdomen]. 61
19098397 2008
48
The safety and effectiveness of endoscopic biliary decompression by plastic stent placement in acute suppurative cholangitis compared with nasobiliary drainage. 61
18635173 2008
49
Early surgical management for periampullary retroperitoneal perforation caused by endoscopic sphincterotomy: report of a case. 61
19023171 2008
50
Risk factors for acute suppurative cholangitis caused by bile duct stones. 61
17556906 2007

Variations for Suppurative Cholangitis

Expression for Suppurative Cholangitis

Search GEO for disease gene expression data for Suppurative Cholangitis.

Pathways for Suppurative Cholangitis

GO Terms for Suppurative Cholangitis

Biological processes related to Suppurative Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bicarbonate transport GO:0015701 9.37 SLC4A8 SLC4A4
2 regulation of intracellular pH GO:0051453 9.32 SLC4A8 SLC4A4
3 inorganic anion transport GO:0015698 9.26 SLC4A8 SLC4A4
4 anion transport GO:0006820 9.16 SLC4A8 SLC4A4
5 leukotriene D4 biosynthetic process GO:1901750 8.96 GGTLC3 GGT2
6 glutathione catabolic process GO:0006751 8.62 GGTLC3 GGT2

Molecular functions related to Suppurative Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anion transmembrane transporter activity GO:0008509 9.26 SLC4A8 SLC4A4
2 inorganic anion exchanger activity GO:0005452 9.16 SLC4A8 SLC4A4
3 glutathione hydrolase activity GO:0036374 8.96 GGTLC3 GGT2
4 sodium:bicarbonate symporter activity GO:0008510 8.62 SLC4A8 SLC4A4

Sources for Suppurative Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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