MCID: SPP001
MIFTS: 32

Suppurative Lymphadenitis

Categories: Immune diseases

Aliases & Classifications for Suppurative Lymphadenitis

MalaCards integrated aliases for Suppurative Lymphadenitis:

Name: Suppurative Lymphadenitis 12 15
Suppurative Lymphadenopathy 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4639
NCIt 50 C27135
SNOMED-CT 67 48573006
UMLS 70 C0392051

Summaries for Suppurative Lymphadenitis

MalaCards based summary : Suppurative Lymphadenitis, also known as suppurative lymphadenopathy, is related to lymphadenitis and cat-scratch disease. An important gene associated with Suppurative Lymphadenitis is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are PAK Pathway and Immune response CCR3 signaling in eosinophils. Affiliated tissues include lymph node, neutrophil and bone marrow, and related phenotypes are cellular and hematopoietic system

Related Diseases for Suppurative Lymphadenitis

Diseases related to Suppurative Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 338)
# Related Disease Score Top Affiliating Genes
1 lymphadenitis 30.7 IFNG CRP CD4 CCR6
2 cat-scratch disease 30.5 CRP CD4
3 salmonellosis 30.0 IFNG CD4 CCR6
4 cervical adenitis 29.5 PDE6B CRP CD4
5 immune deficiency disease 29.2 IFNG CYBB CRP CD4 CCR6
6 herpes simplex virus keratitis 10.3 CD4 CCR6
7 chancroid 10.3 CD4 CCR6
8 anti-basement membrane glomerulonephritis 10.3 CD4 CCR6
9 esophageal candidiasis 10.3 CD4 CCR6
10 subcutaneous mycosis 10.3 CD4 CCR6
11 pneumonic tularemia 10.3 CD4 CCR6
12 blastomycosis 10.3 CD4 CCR6
13 dacryoadenitis 10.3 CD4 CCR6
14 scabies 10.3 CD4 CCR6
15 autoimmune cholangitis 10.3 CD4 CCR6
16 dermatophytosis 10.3 CD4 CCR6
17 blepharoconjunctivitis 10.3 DOCK8 CD4
18 coccidioidomycosis 10.3 CD4 CCR6
19 legume allergy 10.3 CD4 CCR6
20 fruit allergy 10.3 CD4 CCR6
21 immunodeficiency 16 10.3 CD4 CCR6
22 seborrheic dermatitis 10.3 CD4 CCR6
23 chronic conjunctivitis 10.3 CD4 CCR6
24 autoimmune glomerulonephritis 10.3 CD4 CCR6
25 evans' syndrome 10.3 CD4 CCR6
26 retinal vasculitis 10.3 CD4 CCR6
27 autoimmune disease of urogenital tract 10.3 CD4 CCR6
28 t-cell adult acute lymphocytic leukemia 10.3 CD4 CCR6
29 childhood type dermatomyositis 10.3 CD4 CCR6
30 immunodeficiency 41 with lymphoproliferation and autoimmunity 10.3 DOCK8 CD4
31 anogenital venereal wart 10.3 CD4 CCR6
32 autoimmune disease of eyes, ear, nose and throat 10.3 CD4 CCR6
33 immunodeficiency with hyper-igm, type 3 10.3 DOCK8 CD4
34 intestinal schistosomiasis 10.2 CD4 CCR6
35 immunodeficiency 35 10.2 DOCK8 CCR6
36 immunodeficiency 27b 10.2 DOCK8 CYBB
37 primary thrombocytopenia 10.2 CD4 CCR6
38 vaginitis 10.2 CD4 CCR6
39 necrotic uveal melanoma 10.2 IFNG CD4
40 immunodeficiency 13 10.2 DOCK8 CD4
41 keratoconjunctivitis sicca 10.2 CD4 CCR6
42 ocular tuberculosis 10.2 IFNG CD4
43 blepharitis 10.2 CD4 CCR6
44 adult xanthogranuloma 10.2 FUT4 CD4
45 penicilliosis 10.2 IFNG CD4
46 skin sarcoidosis 10.2 IFNG CD4
47 vernal conjunctivitis 10.2 IFNG CCR6
48 sialadenitis 10.2 CD4 CCR6
49 retinitis pigmentosa 46 10.2 IFNG CD4
50 uveoparotid fever 10.2 IFNG CD4

Graphical network of the top 20 diseases related to Suppurative Lymphadenitis:



Diseases related to Suppurative Lymphadenitis

Symptoms & Phenotypes for Suppurative Lymphadenitis

MGI Mouse Phenotypes related to Suppurative Lymphadenitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 CD4 CYBB DOCK8 FUT4 IFNG NCF1
2 hematopoietic system MP:0005397 9.81 CCR6 CD4 CYBB DOCK8 FUT4 IFNG
3 homeostasis/metabolism MP:0005376 9.61 CCR6 CD4 CRP CYBB FUT4 IFNG
4 immune system MP:0005387 9.28 CCR6 CD4 CRP CYBB DOCK8 FUT4

Drugs & Therapeutics for Suppurative Lymphadenitis

Search Clinical Trials , NIH Clinical Center for Suppurative Lymphadenitis

Genetic Tests for Suppurative Lymphadenitis

Anatomical Context for Suppurative Lymphadenitis

MalaCards organs/tissues related to Suppurative Lymphadenitis:

40
Lymph Node, Neutrophil, Bone Marrow, Skin

Publications for Suppurative Lymphadenitis

Articles related to Suppurative Lymphadenitis:

(show top 50) (show all 147)
# Title Authors PMID Year
1
Factors Affecting Cervical Lymph Node Suppuration in Oropharyngeal Tularemia Cases. 61
33645188 2021
2
Kikuchi Cervical Lymphadenitis in Children: Ultrasound Differentiation From Common Infectious Lymphadenitis. 61
33263358 2020
3
Suppurative lymphadenitis caused by hypermucoid-variant Klebsiella in a Polynesian woman: a case report. 61
32889418 2020
4
[Disseminated infection caused by the bacillus Calmette-Guérin vaccine and SARS-CoV-2 coinfection in a patient with IL-12 receptor β1 subunit deficiency]. 61
33631907 2020
5
Cervical lymphadenopathy in children: a diagnostic tree analysis model based on ultrasonographic and clinical findings. 61
32189052 2020
6
Suppurative Lymphadenitis after Radioactive Iodine Therapy for Graves' Disease: A Rare Complication? 61
31934559 2019
7
Suspected reactivation of extrapulmonary tuberculosis focus after non-medical abuse of anabolic androgenic steroids: a case report. 61
31874100 2019
8
Utility of fine-needle aspiration cytology in the diagnosis of HIV lymphadenopathy. 61
31207176 2019
9
A Case of Incomplete and Atypical Kawasaki Disease Presenting with Retropharyngeal Involvement. 61
31491922 2019
10
Pediatric acute unilateral suppurative lymphadenitis: The role of antibiotic susceptibilities at a large tertiary pediatric care center. 61
30743188 2019
11
Clinical presentation and treatment of melioidosis in the head and neck region. 61
30180912 2018
12
Surgical treatment of non-tuberculous mycobacterial lymphadenitis in children: Our experience and a narrative review. 61
30354841 2018
13
Assessment of Clinically Suspected Tubercular Lymphadenopathy by Real-Time PCR Compared to Non-Molecular Methods on Lymph Node Aspirates. 61
28946148 2018
14
BCG vaccination-induced suppurative lymphadenitis: four signs to pay attention to. 61
28425207 2017
15
Pediatric neck abscesses: No increase in methicillin-resistant Staphylococcus aureus. 61
28964280 2017
16
Bacillus Calmette-Guérin vaccine complications in Iranian children at a University Hospital. 61
28161281 2017
17
Hodgkin's lymphoma masquerading as suppurative lymphadenitis. 61
28701837 2017
18
A New Trend in the Management of Pediatric Deep Neck Abscess: Achievement of the Medical Treatment Alone. 61
29392056 2017
19
Pathogenetic determinants in Kawasaki disease: the haematological point of view. 61
28063205 2017
20
Differences in clinical manifestations of odontogenic and non-odontogenic lymphadenitis. 61
29203744 2017
21
Imaging Findings of Ulceroglandular Tularemia. 61
28580063 2017
22
CLINICAL MANAGEMENT OF LOCALIZED BCG ADVERSE EVENTS IN CHILDREN. 61
27828625 2016
23
Adverse reactions to the Bacillus Calmette-Guérin (BCG) vaccine in new-born infants-an evaluation of the Danish strain 1331 SSI in a randomized clinical trial. 61
27060379 2016
24
Chronic Granulomatous Disease. 61
26865172 2016
25
Fatal Systemic Toxoplasma gondii Infection in a Red Squirrel (Sciurus vulgaris), a Swinhoe's Striped Squirrel (Tamiops swinhoei) and a New World Porcupine (Erethizontidae sp.). 61
26987509 2016
26
Management and outcome of Bacille Calmette-Guérin vaccine adverse reactions. 61
26275478 2015
27
Adverse reactions to Mycobacterium bovis bacille Calmette-Guérin vaccination against tuberculosis in Iranian children. 61
26273579 2015
28
Bartonella henselae infection-associated vasculitis and crescentic glomerulonephritis leading to renal allograft loss. 61
25753276 2015
29
Long-term outcome of patients with p22 (phox) -deficient chronic granulomatous disease on Jeju Island, Korea. 61
25932034 2015
30
Clinical characteristics and needle aspiration management of Bacillus Calmette-Guérin lymphadenitis in children. 61
25737168 2015
31
Role of fine-needle aspiration cytology in human immunodeficiency virus-associated lymphadenopathy: a cross-sectional study from northern India. 61
25418928 2015
32
Role of needle aspiration in diagnosis and management of suppurative bacille calmette-guerin adenitis: an institutional study of 30 cases. 61
25949055 2015
33
Contribution of CT scan and CT-guided aspiration in the management of retropharyngeal abscess in children based on a series of 18 cases. 61
24930845 2014
34
Risk factors for retropharyngeal cellulitis in Kawasaki disease. 61
24958366 2014
35
Investigations into an outbreak of suppurative lymphadenitis with BCG vaccine SSI(®) in Singapore. 61
25173482 2014
36
Sonographic diagnosis of tuberculous lymphadenitis in the neck. 61
25154944 2014
37
Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect. 61
24831405 2014
38
Nodular sclerosing classical Hodgkin lymphoma masquerading as acute suppurative-necrotizing lymphadenitis. 61
21965120 2014
39
Subcutaneous surprise. 61
24669344 2014
40
Tularemia in differential diagnosis of cervical lymphadenopathy: cytologic features of tularemia lymphadenitis. 61
24192314 2014
41
Molecular confirmation of Bacillus Calmette Guerin vaccine related adverse events among Saudi Arabian children. 61
25409184 2014
42
Recurrent Burkholderia gladioli suppurative lymphadenitis associated with neutralizing anti-IL-12p70 autoantibodies. 61
23708995 2013
43
Chronic granulomatous disease with markedly elevated IgE levels mimicking hyperimmunoglobulin E syndrome. 61
23827747 2013
44
Complications of BCG vaccine SSI® recent story and risk management plan: the French experience. 61
23213021 2013
45
Necrotic cervical nodes: usefulness of diffusion-weighted MR imaging in the differentiation of suppurative lymphadenitis from malignancy. 61
22954412 2013
46
Bacille-Calmette-Guérin vaccine-associated suppurative lymphadenitis in Hong Kong Special Administrative Region (China), 2004 to 2012. 61
23908954 2013
47
[Tularemia in Konya region, Turkey]. 61
22639311 2012
48
Safety of intradermal Bacillus Calmette-Guerin vaccine for neonates in Eastern Saudi Arabia. 61
22327758 2012
49
Granulomatous lymphadenitis. 61
22706525 2012
50
Seronegative cat-scratch disease diagnosed by PCR detection of Bartonella henselae DNA in lymph node samples. 61
22358366 2012

Variations for Suppurative Lymphadenitis

Expression for Suppurative Lymphadenitis

Search GEO for disease gene expression data for Suppurative Lymphadenitis.

Pathways for Suppurative Lymphadenitis

Pathways related to Suppurative Lymphadenitis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 NCF2 NCF1 CYBB CD4 CCR6
2
Show member pathways
12.04 NCF2 NCF1 CYBB
3 11.79 NCF2 NCF1 CYBB
4 11.74 NCF2 NCF1 CYBB
5 11.72 NCF2 NCF1 IFNG
6 11.65 NCF2 NCF1 IFNG
7
Show member pathways
11.53 NCF2 NCF1 IFNG CYBB
8
Show member pathways
11.46 NCF2 NCF1 CYBB
9 11.34 IFNG CD4 CCR6
10
Show member pathways
11.07 NCF2 NCF1 CYBB
11 10.97 IFNG CD4
12 10.94 IFNG CD4
13 9.91 NCF2 NCF1 CYBB

GO Terms for Suppurative Lymphadenitis

Cellular components related to Suppurative Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagolysosome GO:0032010 8.96 NCF2 NCF1
2 NADPH oxidase complex GO:0043020 8.8 NCF2 NCF1 CYBB

Biological processes related to Suppurative Lymphadenitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.8 NCF2 NCF1 CYBB CRP
2 cellular response to oxidative stress GO:0034599 9.63 NCF2 NCF1 CYBB
3 electron transport chain GO:0022900 9.61 NCF2 NCF1 CYBB
4 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.58 NCF2 NCF1 CYBB
5 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.54 NCF2 NCF1 CYBB
6 cell redox homeostasis GO:0045454 9.5 NCF2 NCF1 CYBB
7 macrophage differentiation GO:0030225 9.48 IFNG CD4
8 cellular defense response GO:0006968 9.43 NCF2 NCF1 CCR6
9 superoxide metabolic process GO:0006801 9.33 NCF2 NCF1 CYBB
10 superoxide anion generation GO:0042554 9.13 NCF2 NCF1 CYBB
11 respiratory burst GO:0045730 8.8 NCF2 NCF1 CYBB

Molecular functions related to Suppurative Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 superoxide-generating NADPH oxidase activator activity GO:0016176 9.16 NCF2 NCF1
2 electron transfer activity GO:0009055 9.13 NCF2 NCF1 CYBB
3 superoxide-generating NADPH oxidase activity GO:0016175 8.8 NCF2 NCF1 CYBB

Sources for Suppurative Lymphadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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