MCID: SPP001
MIFTS: 31

Suppurative Lymphadenitis

Categories: Immune diseases

Aliases & Classifications for Suppurative Lymphadenitis

MalaCards integrated aliases for Suppurative Lymphadenitis:

Name: Suppurative Lymphadenitis 12 15
Suppurative Lymphadenopathy 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4639
NCIt 49 C27135
SNOMED-CT 67 48573006
UMLS 71 C0392051

Summaries for Suppurative Lymphadenitis

MalaCards based summary : Suppurative Lymphadenitis, also known as suppurative lymphadenopathy, is related to lymphadenitis and immune deficiency disease. An important gene associated with Suppurative Lymphadenitis is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are PAK Pathway and Immune response CCR3 signaling in eosinophils. The drugs BCG vaccine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lymph node.

Related Diseases for Suppurative Lymphadenitis

Diseases related to Suppurative Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 lymphadenitis 31.3 CD4 CCR6 CA8
2 immune deficiency disease 29.1 NCF2 CYBB CD4 CCR6
3 spongiotic dermatitis 10.3 CD4 CCR6
4 anti-basement membrane glomerulonephritis 10.3 CD4 CCR6
5 chancroid 10.3 CD4 CCR6
6 mikulicz disease 10.3 CD4 CCR6
7 esophageal candidiasis 10.3 CD4 CCR6
8 pneumonic tularemia 10.3 CD4 CCR6
9 blastomycosis 10.3 CD4 CCR6
10 scleral disease 10.3 CD4 CCR6
11 autoimmune disease of cardiovascular system 10.3 CD4 CCR6
12 iritis 10.3 CD4 CCR6
13 dacryoadenitis 10.3 CD4 CCR6
14 autoimmune vasculitis 10.3 CD4 CCR6
15 tuberculoid leprosy 10.3 CD4 CCR6
16 dermatophytosis 10.3 CD4 CCR6
17 mucormycosis 10.3 CD4 CCR6
18 central nervous system vasculitis 10.3 CD4 CCR6
19 chronic conjunctivitis 10.3 CD4 CCR6
20 acute proliferative glomerulonephritis 10.3 CD4 CCR6
21 t-cell adult acute lymphocytic leukemia 10.3 CD4 CCR6
22 adult acute lymphocytic leukemia 10.3 CD4 CCR6
23 coccidioidomycosis 10.3 CD4 CCR6
24 autoimmune glomerulonephritis 10.3 CD4 CCR6
25 nut allergy 10.3 CD4 CCR6
26 intestinal schistosomiasis 10.3 CD4 CCR6
27 autoimmune disease of eyes, ear, nose and throat 10.3 CD4 CCR6
28 primary systemic mycosis 10.3 CD4 CCR6
29 thrombocytopenia due to platelet alloimmunization 10.3 CD4 CCR6
30 childhood type dermatomyositis 10.3 CD4 CCR6
31 pneumocystosis 10.3 CD4 CCR6
32 igg4-related disease 10.3 CD4 CCR6
33 autoimmune disease of skin and connective tissue 10.3 CD4 CCR6
34 primary thrombocytopenia 10.3 CD4 CCR6
35 autoimmune gastritis 10.3 CD4 CCR6
36 blepharitis 10.3 CD4 CCR6
37 keratoconjunctivitis sicca 10.3 CD4 CCR6
38 lichen disease 10.3 CD4 CCR6
39 vaginitis 10.3 CD4 CCR6
40 histoplasmosis 10.3 CD4 CCR6
41 eczema herpeticum 10.3 DOCK8 CCR6
42 sialadenitis 10.3 CD4 CCR6
43 autoimmune disease of blood 10.3 CD4 CCR6
44 immunoglobulin alpha deficiency 10.2 CD4 CCR6
45 eyelid disease 10.2 CD4 CCR6
46 plasma protein metabolism disease 10.2 CD4 CCR6
47 folliculitis 10.2 CD4 CCR6
48 genital herpes 10.2 CD4 CCR6
49 lacrimal apparatus disease 10.2 CD4 CCR6
50 common wart 10.2 DOCK8 CD4

Graphical network of the top 20 diseases related to Suppurative Lymphadenitis:



Diseases related to Suppurative Lymphadenitis

Symptoms & Phenotypes for Suppurative Lymphadenitis

Drugs & Therapeutics for Suppurative Lymphadenitis

Drugs for Suppurative Lymphadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
BCG vaccine Investigational Phase 4
2 Vaccines Phase 4
3 Immunologic Factors Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluating the Non-specific Effects of Different BCG Strains in Guinea-Bissau: Randomized Trial of the Impact on Early-life Hospital Admissions and Deaths Recruiting NCT03400878 Phase 4

Search NIH Clinical Center for Suppurative Lymphadenitis

Genetic Tests for Suppurative Lymphadenitis

Anatomical Context for Suppurative Lymphadenitis

MalaCards organs/tissues related to Suppurative Lymphadenitis:

40
Skin, T Cells, Lymph Node, Bone, Thyroid, B Cells, Neutrophil

Publications for Suppurative Lymphadenitis

Articles related to Suppurative Lymphadenitis:

(show top 50) (show all 141)
# Title Authors PMID Year
1
Suppurative Lymphadenitis after Radioactive Iodine Therapy for Graves' Disease: A Rare Complication? 61
31934559 2019
2
Suspected reactivation of extrapulmonary tuberculosis focus after non-medical abuse of anabolic androgenic steroids: a case report. 61
31874100 2019
3
Utility of fine-needle aspiration cytology in the diagnosis of HIV lymphadenopathy. 61
31207176 2019
4
A Case of Incomplete and Atypical Kawasaki Disease Presenting with Retropharyngeal Involvement. 61
31491922 2019
5
Pediatric acute unilateral suppurative lymphadenitis: The role of antibiotic susceptibilities at a large tertiary pediatric care center. 61
30743188 2019
6
Clinical presentation and treatment of melioidosis in the head and neck region. 61
30180912 2018
7
Surgical treatment of non-tuberculous mycobacterial lymphadenitis in children: Our experience and a narrative review. 61
30354841 2018
8
Assessment of Clinically Suspected Tubercular Lymphadenopathy by Real-Time PCR Compared to Non-Molecular Methods on Lymph Node Aspirates. 61
28946148 2018
9
BCG vaccination-induced suppurative lymphadenitis: four signs to pay attention to. 61
28425207 2017
10
Pediatric neck abscesses: No increase in methicillin-resistant Staphylococcus aureus. 61
28964280 2017
11
Bacillus Calmette-Guérin vaccine complications in Iranian children at a University Hospital. 61
28161281 2017
12
Hodgkin's lymphoma masquerading as suppurative lymphadenitis. 61
28701837 2017
13
A New Trend in the Management of Pediatric Deep Neck Abscess: Achievement of the Medical Treatment Alone. 61
29392056 2017
14
Pathogenetic determinants in Kawasaki disease: the haematological point of view. 61
28063205 2017
15
Differences in clinical manifestations of odontogenic and non-odontogenic lymphadenitis. 61
29203744 2017
16
Imaging Findings of Ulceroglandular Tularemia. 61
28580063 2017
17
CLINICAL MANAGEMENT OF LOCALIZED BCG ADVERSE EVENTS IN CHILDREN. 61
27828625 2016
18
Adverse reactions to the Bacillus Calmette-Guérin (BCG) vaccine in new-born infants-an evaluation of the Danish strain 1331 SSI in a randomized clinical trial. 61
27060379 2016
19
Chronic Granulomatous Disease. 61
26865172 2016
20
Fatal Systemic Toxoplasma gondii Infection in a Red Squirrel (Sciurus vulgaris), a Swinhoe's Striped Squirrel (Tamiops swinhoei) and a New World Porcupine (Erethizontidae sp.). 61
26987509 2016
21
Management and outcome of Bacille Calmette-Guérin vaccine adverse reactions. 61
26275478 2015
22
Adverse reactions to Mycobacterium bovis bacille Calmette-Guérin vaccination against tuberculosis in Iranian children. 61
26273579 2015
23
Bartonella henselae infection-associated vasculitis and crescentic glomerulonephritis leading to renal allograft loss. 61
25753276 2015
24
Long-term outcome of patients with p22 (phox) -deficient chronic granulomatous disease on Jeju Island, Korea. 61
25932034 2015
25
Clinical characteristics and needle aspiration management of Bacillus Calmette-Guérin lymphadenitis in children. 61
25737168 2015
26
Role of fine-needle aspiration cytology in human immunodeficiency virus-associated lymphadenopathy: a cross-sectional study from northern India. 61
25418928 2015
27
Role of needle aspiration in diagnosis and management of suppurative bacille calmette-guerin adenitis: an institutional study of 30 cases. 61
25949055 2015
28
Contribution of CT scan and CT-guided aspiration in the management of retropharyngeal abscess in children based on a series of 18 cases. 61
24930845 2014
29
Investigations into an outbreak of suppurative lymphadenitis with BCG vaccine SSI(®) in Singapore. 61
25173482 2014
30
Risk factors for retropharyngeal cellulitis in Kawasaki disease. 61
24958366 2014
31
Sonographic diagnosis of tuberculous lymphadenitis in the neck. 61
25154944 2014
32
Nodular sclerosing classical Hodgkin lymphoma masquerading as acute suppurative-necrotizing lymphadenitis. 61
21965120 2014
33
Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect. 61
24831405 2014
34
Molecular confirmation of Bacillus Calmette Guerin vaccine related adverse events among Saudi Arabian children. 61
25409184 2014
35
Subcutaneous surprise. 61
24669344 2014
36
Tularemia in differential diagnosis of cervical lymphadenopathy: cytologic features of tularemia lymphadenitis. 61
24192314 2014
37
Recurrent Burkholderia gladioli suppurative lymphadenitis associated with neutralizing anti-IL-12p70 autoantibodies. 61
23708995 2013
38
Chronic granulomatous disease with markedly elevated IgE levels mimicking hyperimmunoglobulin E syndrome. 61
23827747 2013
39
Complications of BCG vaccine SSI® recent story and risk management plan: the French experience. 61
23213021 2013
40
Bacille-Calmette-Guérin vaccine-associated suppurative lymphadenitis in Hong Kong Special Administrative Region (China), 2004 to 2012. 61
23908954 2013
41
Necrotic cervical nodes: usefulness of diffusion-weighted MR imaging in the differentiation of suppurative lymphadenitis from malignancy. 61
22954412 2013
42
[Tularemia in Konya region, Turkey]. 61
22639311 2012
43
Safety of intradermal Bacillus Calmette-Guerin vaccine for neonates in Eastern Saudi Arabia. 61
22327758 2012
44
Granulomatous lymphadenitis. 61
22706525 2012
45
Seronegative cat-scratch disease diagnosed by PCR detection of Bartonella henselae DNA in lymph node samples. 61
22358366 2012
46
[Bacille Calmette-Guérin adenitis: diagnostic and therapeutic guidelines]. 61
22849911 2011
47
Late onset suppurative lymphadenopathy induced by bacillus Calmette–Gue´ rin (BCG) vaccination. 61
21998836 2011
48
Affects of N-terminal variation in the SeM protein of Streptococcus equi on antibody and fibrinogen binding. 61
20005857 2010
49
Inflammatory BCG adenitis associated with immune reconstitution following allogeneic haematopoietic stem cell transplant in infancy. 61
19606456 2010
50
[Literature review of adverse events following immunization of Bacillus Calemtte-Guerin vaccine]. 61
20518321 2009

Variations for Suppurative Lymphadenitis

Expression for Suppurative Lymphadenitis

Search GEO for disease gene expression data for Suppurative Lymphadenitis.

Pathways for Suppurative Lymphadenitis

Pathways related to Suppurative Lymphadenitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 NCF2 NCF1 CYBB CD4 CCR6
2
Show member pathways
11.95 NCF2 NCF1 CYBB
3
Show member pathways
11.82 NCF2 NCF1 CYBB
4 11.68 NCF2 NCF1 CYBB
5 11.52 NCF2 NCF1 CYBB
6
Show member pathways
11.3 NCF2 NCF1 CYBB
7
Show member pathways
10.87 NCF2 NCF1 CYBB
8 9.91 NCF2 NCF1 CYBB

GO Terms for Suppurative Lymphadenitis

Cellular components related to Suppurative Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.63 RIT2 NCF2 NCF1 CYBB CD4 CCR6
2 phagolysosome GO:0032010 8.96 NCF2 NCF1
3 NADPH oxidase complex GO:0043020 8.8 NCF2 NCF1 CYBB

Biological processes related to Suppurative Lymphadenitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular response to oxidative stress GO:0034599 9.65 NCF2 NCF1 CYBB
2 electron transport chain GO:0022900 9.63 NCF2 NCF1 CYBB
3 cell redox homeostasis GO:0045454 9.61 NCF2 NCF1 CYBB
4 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.58 NCF2 NCF1 CYBB
5 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.54 NCF2 NCF1 CYBB
6 cellular defense response GO:0006968 9.5 NCF2 NCF1 CCR6
7 cellular response to cadmium ion GO:0071276 9.49 NCF1 CYBB
8 superoxide metabolic process GO:0006801 9.33 NCF2 NCF1 CYBB
9 maintenance of protein location in cell GO:0032507 9.26 RIT2 CD4
10 superoxide anion generation GO:0042554 9.13 NCF2 NCF1 CYBB
11 respiratory burst GO:0045730 8.8 NCF2 NCF1 CYBB

Molecular functions related to Suppurative Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 superoxide-generating NADPH oxidase activator activity GO:0016176 9.16 NCF2 NCF1
2 electron transfer activity GO:0009055 9.13 NCF2 NCF1 CYBB
3 superoxide-generating NADPH oxidase activity GO:0016175 8.8 NCF2 NCF1 CYBB

Sources for Suppurative Lymphadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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