MCID: SPP008
MIFTS: 50

Suppurative Otitis Media

Categories: Ear diseases

Aliases & Classifications for Suppurative Otitis Media

MalaCards integrated aliases for Suppurative Otitis Media:

Name: Suppurative Otitis Media 12 15 73
Otitis Media with Effusion - Purulent 12
Otitis Media, Suppurative 44
Purulent Otitis Media 12

Classifications:



Summaries for Suppurative Otitis Media

Disease Ontology : 12 A otitis media which involves inflammation of the middle ear with infected effusion containing pus.

MalaCards based summary : Suppurative Otitis Media, also known as otitis media with effusion - purulent, is related to chronic purulent otitis media and otitis media. An important gene associated with Suppurative Otitis Media is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Acetylcysteine and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and testes, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Suppurative Otitis Media

Diseases related to Suppurative Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 chronic purulent otitis media 33.0 HSF4 WIPF1
2 otitis media 32.4 CD40LG IL1B TLR2 TLR4
3 mastoiditis 31.2 CRP SLC29A3
4 mesenteric lymphadenitis 30.6 CRP TLR2
5 streptococcal meningitis 30.3 CD40LG CRP
6 bacterial meningitis 30.1 CRP IL1B TLR2
7 meningitis 29.9 CD40LG CRP IL1B TLR2
8 appendicitis 29.8 CRP IL1B
9 pneumonia 28.0 CD40LG CRP IL1B TLR2 TLR4 TLR5
10 chronic tubotympanic suppurative otitis media 12.7
11 non-suppurative otitis media 12.5
12 purulent acute otitis media 12.1
13 chronic atticoantral disease 11.8
14 serous glue ear 11.4
15 acute serous otitis media 11.3
16 focal labyrinthitis 11.3
17 eustachian tube disease 11.3
18 acute cervicitis 10.7 TLR2 TLR4
19 penicilliosis 10.7 TLR2 TLR4
20 myositis fibrosa 10.7 TLR2 TLR4
21 periodontitis, chronic 10.7 IL1B TLR2
22 campylobacteriosis 10.7 IL1B TLR4
23 haemophilus influenzae 10.6 IL1B TLR2
24 alveolar echinococcosis 10.6 TLR2 TLR4
25 endometrial disease 10.6 IL1B TLR4
26 neisseria meningitidis infection 10.6 TLR2 TLR4
27 periapical periodontitis 10.6 IL1B TLR2
28 cysticercosis 10.6 IL1B TLR4
29 dental abscess 10.6 CRP TLR4
30 uremic pruritus 10.5 CRP IL1B
31 pericoronitis 10.5 CRP IL1B
32 coccidioidomycosis 10.5 CD40LG TLR4
33 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
34 extrapulmonary tuberculosis 10.5 IL1B TLR2
35 cervical adenitis 10.5 HSF4 IL1B
36 schnitzler syndrome 10.4 CD40LG IL1B
37 cystic echinococcosis 10.4 CD40LG TLR4
38 periodontosis 10.4 CD40LG TLR4
39 primary systemic mycosis 10.4 CD40LG TLR2
40 bone fracture 10.4 CRP TLR4
41 pharyngitis 10.4 CRP IL1B
42 invasive aspergillosis 10.4 TLR2 TLR4
43 bacteriuria 10.4 CD40LG TLR4
44 lemierre's syndrome 10.4 CRP TLR5
45 ocular toxoplasmosis 10.4 CD40LG TLR5
46 muckle-wells syndrome 10.4 CRP IL1B
47 osteosclerotic myeloma 10.4 CD40LG IL1B
48 pleural disease 10.4 CRP IL1B
49 wells syndrome 10.4 CRP IL1B
50 jejunoileitis 10.4 CD40LG IL1B

Graphical network of the top 20 diseases related to Suppurative Otitis Media:



Diseases related to Suppurative Otitis Media

Symptoms & Phenotypes for Suppurative Otitis Media

MGI Mouse Phenotypes related to Suppurative Otitis Media:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 CD40LG CRP IL1B TLR2 TLR4 TLR5
2 hematopoietic system MP:0005397 9.5 WIPF1 CD40LG IL1B SLC29A3 TLR2 TLR4
3 immune system MP:0005387 9.23 CD40LG CRP IL1B SLC29A3 TLR2 TLR4

Drugs & Therapeutics for Suppurative Otitis Media

Drugs for Suppurative Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4 Anti-Bacterial Agents Phase 4,Phase 1,Not Applicable
5 Anti-Infective Agents Phase 4,Phase 1,Not Applicable
6 Topoisomerase Inhibitors Phase 4,Phase 1
7 Cytochrome P-450 Enzyme Inhibitors Phase 4,Not Applicable
8 Antidotes Phase 4
9 Antiemetics Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Antineoplastic Agents, Hormonal Phase 4
12 Antioxidants Phase 4
13 Antiviral Agents Phase 4
14 Autonomic Agents Phase 4
15 BB 1101 Phase 4
16 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
17 Dexamethasone acetate Phase 4 1177-87-3
18 Expectorants Phase 4
19 Gastrointestinal Agents Phase 4
20 glucocorticoids Phase 4
21 HIV Protease Inhibitors Phase 4
22 Hormone Antagonists Phase 4
23 Hormones Phase 4
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
25 N-monoacetylcystine Phase 4
26 Peripheral Nervous System Agents Phase 4
27 Pharmaceutical Solutions Phase 4
28
protease inhibitors Phase 4
29 Protective Agents Phase 4
30 Respiratory System Agents Phase 4
31 Pazufloxacin Investigational Phase 1 127045-41-4
32 Antitubercular Agents Phase 1
33 Fluoroquinolones Phase 1
34 Nucleic Acid Synthesis Inhibitors Phase 1
35
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
36
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
37
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
38
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
39 Antimalarials Not Applicable
40 Antiparasitic Agents Not Applicable
41 Antiprotozoal Agents Not Applicable
42 Folic Acid Antagonists Not Applicable
43 Renal Agents Not Applicable
44 Trimethoprim, Sulfamethoxazole Drug Combination Not Applicable
45 Vitamin B Complex Not Applicable
46 Folate Nutraceutical Not Applicable
47 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media Unknown status NCT00271778 Phase 3
3 Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection
4 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi Unknown status NCT02779907
5 Host-pathogen Interaction in Otitis Media Unknown status NCT00847756
6 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Not Applicable Sulfamethoxazole-trimethoprim;Placebo
7 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Not yet recruiting NCT03456739
8 Evaluation of Prognostic Factors in Tympanoplasty Not yet recruiting NCT03416725
9 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Not yet recruiting NCT02716376 Not Applicable

Search NIH Clinical Center for Suppurative Otitis Media

Cochrane evidence based reviews: otitis media, suppurative

Genetic Tests for Suppurative Otitis Media

Anatomical Context for Suppurative Otitis Media

MalaCards organs/tissues related to Suppurative Otitis Media:

41
Bone, Brain, Testes, Neutrophil, Temporal Lobe, T Cells

Publications for Suppurative Otitis Media

Articles related to Suppurative Otitis Media:

(show top 50) (show all 578)
# Title Authors Year
1
Risk factors of sensorineural hearing loss in patients with unilateral safe chronic suppurative otitis media. ( 29331307 )
2018
2
To Evaluate and Compare the Result of Ossiculoplasty Using Different Types of Graft Materials and Prosthesis in Cases of Ossicular Discontinuity in Chronic Suppurative Otitis Media Cases. ( 29456937 )
2018
3
The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media. ( 29951099 )
2018
4
Efficacy of Boric Acid as a Treatment of Choice for Chronic Suppurative Otitis Media and Its Ototoxicity. ( 29383205 )
2018
5
Fungal Suppurative Otitis Media (Histopathology) Among Patients in North India. ( 29671212 )
2018
6
Development of an ear cap in chronic suppurative otitis media using additive manufacturing and TRIZ. ( 29916767 )
2018
7
Aerobic bacteria associated with chronic suppurative otitis media in Angola. ( 29720274 )
2018
8
Efficacy of Empirical Therapy With Combined Ciprofloxacin Versus Topical Drops Alone in Patients With Tubotympanic Chronic Suppurative Otitis Media: A Randomized Double-Blind Controlled Trial. ( 29348711 )
2018
9
Shewanella algae in a chronic suppurative otitis media patient with cholesteatoma. ( 29681564 )
2018
10
Gradenigo Syndrome Induced by Suppurative Otitis Media. ( 29894453 )
2018
11
Development and Administration of Chronic Suppurative Otitis Media Questionnaire-12 (COMQ-12) and Chronic Otitis Media Outcome Test-15 (COMOT-15) in Kannada. ( 29619096 )
2018
12
Management of Chronic Suppurative Otitis Media and Otosclerosis in Developing Countries. ( 29525390 )
2018
13
A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media. ( 29151379 )
2018
14
Is Routine Use of High Resolution Computerized Tomography of Temporal Bone in Patients of Atticoantral Chronic Suppurative Otitis Media without Intracranial Complications Justified? ( 29456948 )
2018
15
Quality of life measurements for patients with chronic suppurative otitis media: Italian adaptation of "Chronic Ear Survey". ( 28374871 )
2017
16
[The influence of interleukin gene polymorphism on the serum cytokine level in the patients presenting with chonic suppurative otitis media]. ( 28631672 )
2017
17
High-frequency conductive hearing loss as a diagnostic test for incomplete ossicular discontinuity in non-cholesteatomatous chronic suppurative otitis media. ( 29267386 )
2017
18
Mycology of chronic suppurative otitis media-cholesteatoma disease: An evaluative study. ( 29306568 )
2017
19
Sensorineural hearing loss in patients with chronic suppurative otitis media: Is there a significant correlation? ( 28465813 )
2017
20
Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up. ( 29071059 )
2017
21
Impact of Chronic Suppurative Otitis Media in Pediatric Cochlear Implant Recipients-Insight into the Challenges from a Tertiary Referral Center in UK. ( 28333779 )
2017
22
Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link? ( 28466356 )
2017
23
Facial Nerve Paralysis in Acute Suppurative Otitis Media-Management. ( 28239580 )
2017
24
Comparative Evaluation of Tympanoplasty with or Without Mastoidectomy in Treatment of Chronic Suppurative Otitis Media Tubotympanic Type. ( 28607885 )
2017
25
Prevalence of paediatric chronic suppurative otitis media and hearing impairment in rural Malawi: A cross-sectional survey. ( 29267304 )
2017
26
Central Nervous System Inflammatory Myofibroblastic Tumor Masquerading as Chronic Suppurative Otitis Media. ( 28904584 )
2017
27
Fluoroquinolone-Resistant Alcaligenes faecalis Related to Chronic Suppurative Otitis Media, Angola. ( 28930018 )
2017
28
Gradenigo's Syndrome in a Patient with Chronic Suppurative Otitis Media, Petrous Apicitis, and Meningitis. ( 28955030 )
2017
29
Microbiology of Chronic Suppurative Otitis Media in a Tertiary Care Hospital in Bangladesh. ( 28919615 )
2017
30
Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media. ( 27177975 )
2016
31
Evaluation of Role of Mastoid Surgery in the Management of Safe Chronic Suppurative Otitis Media. ( 27833868 )
2016
32
Molecular Microbiological Profile of Chronic Suppurative Otitis Media. ( 27487953 )
2016
33
Changes in antibiotic resistance in recurrent Pseudomonas aeruginosa infections of chronic suppurative otitis media. ( 27792822 )
2016
34
Chronic Suppurative Otitis Media Complicated With Mastoiditis: An Unusual Presentation of Tuberculosis. ( 27865308 )
2016
35
Etiological factors associated with chronic suppurative otitis media in a population of Han adults in China. ( 27206699 )
2016
36
Predictors of disease complications and treatment outcome among patients with chronic suppurative otitis media attending a tertiary hospital, Mwanza Tanzania. ( 26766925 )
2016
37
Preoperative Predictors in Chronic Suppurative Otitis Media for Ossicular Chain Discontinuity: A Cross-Sectional Study. ( 27490829 )
2016
38
Do tissue spears used to clear ear canal pus improve hearing? A case series study of hearing in remote Australian Aboriginal children with chronic suppurative otitis media before and after dry mopping with tissue spears. ( 26685792 )
2016
39
Characterization of the T-cell subpopulations in the granulation tissues of chronic suppurative otitis media. ( 27313854 )
2016
40
Prevalence and associated factors of chronic suppurative otitis media: Data from the Korea National Health and Nutrition Examination Survey, 2009-2012. ( 27076099 )
2016
41
Frequency of Sensorineural hearing loss in chronic suppurative otitis media. ( 27895351 )
2016
42
Chronic suppurative otitis media, middle ear pathology and corresponding hearing loss in a cohort of Greenlandic children. ( 26968069 )
2016
43
Aspergillus fumigatus carrying TR34/L98H resistance allele causing complicated suppurative otitis media in Tanzania: Call for improved diagnosis of fungi in sub-Saharan Africa. ( 27589956 )
2016
44
The evaluation of eustachian tube paratubal structures using magnetic resonance imaging in patients with chronic suppurative otitis media. ( 27008280 )
2016
45
Why are ototopical aminoglycosides still first-line therapy for chronic suppurative otitis media? A systematic review and discussion of aminoglycosides versus quinolones. ( 26584651 )
2016
46
Knowledge, attitudes, beliefs and practices related to chronic suppurative otitis media and hearing impairment in Pokhara, Nepal. ( 26567594 )
2015
47
Is chronic suppurative otitis media a neglected tropical disease? ( 25811602 )
2015
48
A study protocol for a cluster randomised trial for the prevention of chronic suppurative otitis media in children in Jumla, Nepal. ( 26425113 )
2015
49
Patency of the aditus ad antrum in tubotympanic chronic suppurative otitis media. ( 25422281 )
2015
50
Impact of Educational Program on the Management of Chronic Suppurative Otitis Media among Children. ( 25792984 )
2015

Variations for Suppurative Otitis Media

Expression for Suppurative Otitis Media

Search GEO for disease gene expression data for Suppurative Otitis Media.

Pathways for Suppurative Otitis Media

Pathways related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 CD40LG CRP IL1B TLR2 TLR4 TLR5
2
Show member pathways
13.16 CD40LG IL1B TLR2 TLR4 TLR5
3
Show member pathways
12.79 IL1B TLR2 TLR4 TLR5
4
Show member pathways
12.55 IL1B TLR2 TLR4 TLR5
5
Show member pathways
12.34 CD40LG IL1B TLR2 TLR4 TLR5
6
Show member pathways
12.2 IL1B TLR2 TLR4 TLR5
7
Show member pathways
12.11 IL1B TLR2 TLR5
8
Show member pathways
12.05 TLR2 TLR4 TLR5
9 12.01 IL1B TLR2 TLR4
10
Show member pathways
12.01 IL1B TLR2 TLR4 TLR5
11
Show member pathways
12 IL1B TLR2 TLR5
12
Show member pathways
11.98 CD40LG IL1B TLR2 TLR4
13 11.95 TLR2 TLR4 TLR5
14
Show member pathways
11.89 IL1B TLR2 TLR4 TLR5
15
Show member pathways
11.89 CD40LG IL1B TLR2 TLR4 TLR5
16 11.71 IL1B TLR2 TLR4
17 11.69 CD40LG IL1B TLR4
18 11.65 IL1B TLR2 TLR4
19
Show member pathways
11.65 IL1B TLR2 TLR4 TLR5
20 11.62 IL1B TLR4 TLR5
21 11.6 TLR2 TLR4 TLR5
22 11.31 IL1B TLR2 TLR4
23 11.2 IL1B TLR2 TLR4 TLR5
24 11.17 IL1B TLR4
25 11.12 CD40LG TLR4
26 11 IL1B TLR2
27 10.61 CD40LG IL1B TLR2 TLR4

GO Terms for Suppurative Otitis Media

Cellular components related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic component of plasma membrane GO:0031226 8.62 TLR2 TLR4

Biological processes related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.89 CRP TLR2 TLR4 TLR5
2 immune response GO:0006955 9.88 CD40LG IL1B TLR2 TLR4
3 positive regulation of gene expression GO:0010628 9.85 CRP IL1B TLR2 TLR4
4 response to lipopolysaccharide GO:0032496 9.78 IL1B TLR2 TLR4
5 cellular response to mechanical stimulus GO:0071260 9.7 IL1B TLR4 TLR5
6 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B TLR2 TLR4
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 CD40LG IL1B TLR2 TLR4
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.65 IL1B TLR2 TLR4
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 IL1B TLR4 TLR5
10 positive regulation of tumor necrosis factor production GO:0032760 9.62 TLR2 TLR4
11 toll-like receptor signaling pathway GO:0002224 9.62 TLR2 TLR4
12 positive regulation of interferon-gamma production GO:0032729 9.61 IL1B TLR4
13 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.61 TLR2 TLR4 TLR5
14 positive regulation of interferon-beta production GO:0032728 9.6 TLR2 TLR4
15 positive regulation of chemokine production GO:0032722 9.58 TLR2 TLR4
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 IL1B TLR2 TLR4
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.57 TLR2 TLR4
18 I-kappaB phosphorylation GO:0007252 9.56 TLR2 TLR4
19 cellular response to lipoteichoic acid GO:0071223 9.54 TLR2 TLR4
20 positive regulation of toll-like receptor signaling pathway GO:0034123 9.51 TLR2 TLR5
21 positive regulation of interleukin-12 production GO:0032735 9.5 CD40LG TLR2 TLR4
22 positive regulation of interleukin-10 production GO:0032733 9.43 CD40LG TLR2 TLR4
23 inflammatory response GO:0006954 9.43 CD40LG CRP IL1B TLR2 TLR4 TLR5
24 regulation of cytokine secretion GO:0050707 9.33 TLR2 TLR4 TLR5
25 positive regulation of interleukin-8 production GO:0032757 8.92 IL1B TLR2 TLR4 TLR5

Molecular functions related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR5
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Suppurative Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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