MCID: SPP008
MIFTS: 50

Suppurative Otitis Media

Categories: Ear diseases

Aliases & Classifications for Suppurative Otitis Media

MalaCards integrated aliases for Suppurative Otitis Media:

Name: Suppurative Otitis Media 12 15 17 74
Otitis Media with Effusion - Purulent 12
Otitis Media, Suppurative 45
Purulent Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11506
ICD9CM 36 382 382.4
MeSH 45 D010035
SNOMED-CT 69 38394007 39288006
UMLS 74 C0029888

Summaries for Suppurative Otitis Media

Disease Ontology : 12 A otitis media which involves inflammation of the middle ear with infected effusion containing pus.

MalaCards based summary : Suppurative Otitis Media, also known as otitis media with effusion - purulent, is related to chronic purulent otitis media and otitis media. An important gene associated with Suppurative Otitis Media is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and NF-KappaB Family Pathway. The drugs Acetylcysteine and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and testes, and related phenotypes are hematopoietic system and immune system

Related Diseases for Suppurative Otitis Media

Diseases related to Suppurative Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 chronic purulent otitis media 33.7 HSF4 WIPF1
2 otitis media 33.2 IL1B TLR2 TLR4
3 meningitis 30.8 CRP IL1B TLR2
4 mastoiditis 30.5 CRP SLC29A3
5 lymphadenitis 30.5 IL1B TLR4
6 mesenteric lymphadenitis 30.4 CRP TLR2
7 appendicitis 30.3 CRP IL1B
8 bacterial meningitis 30.1 CRP IL1B TLR2
9 pneumonia 29.4 CRP IL1B TLR2 TLR4 TLR5
10 chronic tubotympanic suppurative otitis media 12.9
11 non-suppurative otitis media 12.7
12 purulent acute otitis media 12.4
13 chronic atticoantral disease 12.0
14 serous glue ear 11.6
15 acute serous otitis media 11.5
16 focal labyrinthitis 11.4
17 eustachian tube disease 11.4
18 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
19 thrombosis 10.4
20 sensorineural hearing loss 10.4
21 trench fever 10.3 TLR2 TLR4
22 fungal keratitis 10.3 TLR2 TLR4
23 acute cervicitis 10.3 TLR2 TLR4
24 penicilliosis 10.3 TLR2 TLR4
25 myositis fibrosa 10.3 TLR2 TLR4
26 cholesteatoma of middle ear 10.3
27 lateral sinus thrombosis 10.3
28 spondylarthropathy 10.3 TLR2 TLR4
29 campylobacteriosis 10.3 IL1B TLR4
30 neisseria meningitidis infection 10.3 TLR2 TLR4
31 periodontitis, chronic 10.3 IL1B TLR2
32 alveolar echinococcosis 10.3 TLR2 TLR4
33 echinococcosis 10.3 TLR2 TLR4
34 endometrial disease 10.3 IL1B TLR4
35 cysticercosis 10.3 IL1B TLR4
36 haemophilus influenzae 10.3 IL1B TLR2
37 congenital cytomegalovirus 10.3 IL1B TLR2
38 dental abscess 10.3 CRP TLR4
39 periapical periodontitis 10.3 IL1B TLR2
40 invasive aspergillosis 10.3 TLR2 TLR4
41 primary systemic mycosis 10.2 IL1B TLR2
42 pyelitis 10.2 CRP TLR4
43 pericoronitis 10.2 CRP IL1B
44 paracoccidioidomycosis 10.2 TLR2 TLR4
45 schnitzler syndrome 10.2 CRP IL1B
46 uremic pruritus 10.2 CRP IL1B
47 extrapulmonary tuberculosis 10.2 IL1B TLR2
48 idiopathic neutropenia 10.2 IL1B TLR4
49 bacterial sepsis 10.2 CRP TLR4
50 mycoplasma pneumoniae pneumonia 10.2 CRP TLR2

Graphical network of the top 20 diseases related to Suppurative Otitis Media:



Diseases related to Suppurative Otitis Media

Symptoms & Phenotypes for Suppurative Otitis Media

MGI Mouse Phenotypes related to Suppurative Otitis Media:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 IL1B SLC29A3 TLR2 TLR4 TLR5 WIPF1
2 immune system MP:0005387 9.5 CRP IL1B SLC29A3 TLR2 TLR4 TLR5
3 neoplasm MP:0002006 8.92 IL1B SLC29A3 TLR2 TLR4

Drugs & Therapeutics for Suppurative Otitis Media

Drugs for Suppurative Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
5 Anti-Bacterial Agents Phase 4,Phase 1,Not Applicable
6 Anti-Infective Agents Phase 4,Phase 1,Not Applicable
7 Topoisomerase Inhibitors Phase 4,Phase 1
8 Cytochrome P-450 Enzyme Inhibitors Phase 4,Not Applicable
9 Antioxidants Phase 4
10 Expectorants Phase 4
11 N-monoacetylcystine Phase 4
12 Peripheral Nervous System Agents Phase 4,Not Applicable
13 Antidotes Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Antiviral Agents Phase 4
16 HIV Protease Inhibitors Phase 4
17 Free Radical Scavengers Phase 4
18 Hormones Phase 4,Not Applicable
19
protease inhibitors Phase 4
20 Autonomic Agents Phase 4
21 BB 1101 Phase 4
22 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
23 Antineoplastic Agents, Hormonal Phase 4
24 Hormone Antagonists Phase 4
25 Antiemetics Phase 4
26 Respiratory System Agents Phase 4
27 Gastrointestinal Agents Phase 4
28 glucocorticoids Phase 4
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
30 Pharmaceutical Solutions Phase 4
31 Protective Agents Phase 4
32
carbamide peroxide Approved Phase 1 124-43-6
33 Pazufloxacin Investigational Phase 1 127045-41-4
34 Antitubercular Agents Phase 1
35 Fluoroquinolones Phase 1
36 Nucleic Acid Synthesis Inhibitors Phase 1
37 Anti-Infective Agents, Local Phase 1
38
leucovorin Approved Not Applicable 58-05-9 6006 143
39
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
40
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
41
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
42 Vitamin B9 Not Applicable
43 Folate Not Applicable
44 Antiparasitic Agents Not Applicable
45 Anti-Infective Agents, Urinary Not Applicable
46 Renal Agents Not Applicable
47 Folic Acid Antagonists Not Applicable
48 Antiprotozoal Agents Not Applicable
49 Trimethoprim, Sulfamethoxazole Drug Combination Not Applicable
50 Vitamin B Complex Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media Unknown status NCT00271778 Phase 3
3 Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection
4 Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media Recruiting NCT03675841 Phase 1 Pazufloxacin Mesilate ear drops
5 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi Unknown status NCT02779907
6 Host-pathogen Interaction in Otitis Media Unknown status NCT00847756
7 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Unknown status NCT02716376 Not Applicable
8 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Not Applicable Sulfamethoxazole-trimethoprim;Placebo
9 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Not yet recruiting NCT03456739
10 Evaluation of Prognostic Factors in Tympanoplasty Not yet recruiting NCT03416725
11 Preemptive Pregabalin in Myringoplasty Withdrawn NCT03603626 Not Applicable Pregabalin 150mg;Placebo oral capsule

Search NIH Clinical Center for Suppurative Otitis Media

Cochrane evidence based reviews: otitis media, suppurative

Genetic Tests for Suppurative Otitis Media

Anatomical Context for Suppurative Otitis Media

MalaCards organs/tissues related to Suppurative Otitis Media:

42
Bone, Brain, Testes, Neutrophil, Temporal Lobe, Colon, T Cells

Publications for Suppurative Otitis Media

Articles related to Suppurative Otitis Media:

(show top 50) (show all 600)
# Title Authors Year
1
The Value of Diffusion-Weighted MRI in the Long-term follow-up After Subtotal Petrosectomy for Extensive Cholesteatoma and Chronic Suppurative Otitis Media. ( 30531639 )
2019
2
The Role of Routine Culture in the Treatment of Chronic Suppurative Otitis Media: Implications for the Standard of Care in Rural Areas of South Africa. ( 30626120 )
2019
3
Correlation of Eustachian Tube Dysfunction with Results of Tympanoplasty in Mucosal Type of Chronic Suppurative Otitis Media. ( 30906705 )
2019
4
Risk factors of sensorineural hearing loss in patients with unilateral safe chronic suppurative otitis media. ( 29331307 )
2018
5
To Evaluate and Compare the Result of Ossiculoplasty Using Different Types of Graft Materials and Prosthesis in Cases of Ossicular Discontinuity in Chronic Suppurative Otitis Media Cases. ( 29456937 )
2018
6
The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media. ( 29951099 )
2018
7
Efficacy of Boric Acid as a Treatment of Choice for Chronic Suppurative Otitis Media and Its Ototoxicity. ( 29383205 )
2018
8
Fungal Suppurative Otitis Media (Histopathology) Among Patients in North India. ( 29671212 )
2018
9
Development of an ear cap in chronic suppurative otitis media using additive manufacturing and TRIZ. ( 29916767 )
2018
10
Aerobic bacteria associated with chronic suppurative otitis media in Angola. ( 29720274 )
2018
11
Efficacy of Empirical Therapy With Combined Ciprofloxacin Versus Topical Drops Alone in Patients With Tubotympanic Chronic Suppurative Otitis Media: A Randomized Double-Blind Controlled Trial. ( 29348711 )
2018
12
Shewanella algae in a chronic suppurative otitis media patient with cholesteatoma. ( 29681564 )
2018
13
Gradenigo Syndrome Induced by Suppurative Otitis Media. ( 29894453 )
2018
14
Development and Administration of Chronic Suppurative Otitis Media Questionnaire-12 (COMQ-12) and Chronic Otitis Media Outcome Test-15 (COMOT-15) in Kannada. ( 29619096 )
2018
15
Management of Chronic Suppurative Otitis Media and Otosclerosis in Developing Countries. ( 29525390 )
2018
16
A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media. ( 29151379 )
2018
17
Is Routine Use of High Resolution Computerized Tomography of Temporal Bone in Patients of Atticoantral Chronic Suppurative Otitis Media without Intracranial Complications Justified? ( 29456948 )
2018
18
Comment to Empirical Therapy for Chronic Suppurative Otitis Media. ( 30479492 )
2018
19
Three cases of Chronic Suppurative Otitis Media (CSOM) caused by Kerstersia gyiorum and a review of the literature. ( 30555142 )
2018
20
Implementation and results of a surgical training programme for chronic suppurative otitis media in Cambodia. ( 29998817 )
2018
21
Citric Acid as an Alternative to Boric Acid in the Treatment of Chronic Suppurative Otitis Media. ( 30049178 )
2018
22
Causes of Delayed Care Seeking for Chronic Suppurative Otitis Media at a Rwandan Tertiary Hospital. ( 30057615 )
2018
23
Effectiveness of Type I Tympanoplasty in Wet and Dry Ear in Safe Chronic Suppurative Otitis Media. ( 30211083 )
2018
24
Quality of life measurements for patients with chronic suppurative otitis media: Italian adaptation of "Chronic Ear Survey". ( 28374871 )
2017
25
[The influence of interleukin gene polymorphism on the serum cytokine level in the patients presenting with chonic suppurative otitis media]. ( 28631672 )
2017
26
High-frequency conductive hearing loss as a diagnostic test for incomplete ossicular discontinuity in non-cholesteatomatous chronic suppurative otitis media. ( 29267386 )
2017
27
Mycology of chronic suppurative otitis media-cholesteatoma disease: An evaluative study. ( 29306568 )
2017
28
Sensorineural hearing loss in patients with chronic suppurative otitis media: Is there a significant correlation? ( 28465813 )
2017
29
Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up. ( 29071059 )
2017
30
Impact of Chronic Suppurative Otitis Media in Pediatric Cochlear Implant Recipients-Insight into the Challenges from a Tertiary Referral Center in UK. ( 28333779 )
2017
31
Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link? ( 28466356 )
2017
32
Facial Nerve Paralysis in Acute Suppurative Otitis Media-Management. ( 28239580 )
2017
33
Comparative Evaluation of Tympanoplasty with or Without Mastoidectomy in Treatment of Chronic Suppurative Otitis Media Tubotympanic Type. ( 28607885 )
2017
34
Prevalence of paediatric chronic suppurative otitis media and hearing impairment in rural Malawi: A cross-sectional survey. ( 29267304 )
2017
35
Central Nervous System Inflammatory Myofibroblastic Tumor Masquerading as Chronic Suppurative Otitis Media. ( 28904584 )
2017
36
Fluoroquinolone-Resistant Alcaligenes faecalis Related to Chronic Suppurative Otitis Media, Angola. ( 28930018 )
2017
37
Gradenigo's Syndrome in a Patient with Chronic Suppurative Otitis Media, Petrous Apicitis, and Meningitis. ( 28955030 )
2017
38
Microbiology of Chronic Suppurative Otitis Media in a Tertiary Care Hospital in Bangladesh. ( 28919615 )
2017
39
Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media. ( 27177975 )
2016
40
Evaluation of Role of Mastoid Surgery in the Management of Safe Chronic Suppurative Otitis Media. ( 27833868 )
2016
41
Molecular Microbiological Profile of Chronic Suppurative Otitis Media. ( 27487953 )
2016
42
Changes in antibiotic resistance in recurrent Pseudomonas aeruginosa infections of chronic suppurative otitis media. ( 27792822 )
2016
43
Chronic Suppurative Otitis Media Complicated With Mastoiditis: An Unusual Presentation of Tuberculosis. ( 27865308 )
2016
44
Etiological factors associated with chronic suppurative otitis media in a population of Han adults in China. ( 27206699 )
2016
45
Predictors of disease complications and treatment outcome among patients with chronic suppurative otitis media attending a tertiary hospital, Mwanza Tanzania. ( 26766925 )
2016
46
Preoperative Predictors in Chronic Suppurative Otitis Media for Ossicular Chain Discontinuity: A Cross-Sectional Study. ( 27490829 )
2016
47
Do tissue spears used to clear ear canal pus improve hearing? A case series study of hearing in remote Australian Aboriginal children with chronic suppurative otitis media before and after dry mopping with tissue spears. ( 26685792 )
2016
48
Characterization of the T-cell subpopulations in the granulation tissues of chronic suppurative otitis media. ( 27313854 )
2016
49
Prevalence and associated factors of chronic suppurative otitis media: Data from the Korea National Health and Nutrition Examination Survey, 2009-2012. ( 27076099 )
2016
50
Frequency of Sensorineural hearing loss in chronic suppurative otitis media. ( 27895351 )
2016

Variations for Suppurative Otitis Media

Expression for Suppurative Otitis Media

Search GEO for disease gene expression data for Suppurative Otitis Media.

Pathways for Suppurative Otitis Media

Pathways related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 IL1B TLR2 TLR4 TLR5
2
Show member pathways
12.43 IL1B TLR2 TLR4 TLR5
3
Show member pathways
12.36 IL1B TLR2 TLR4 TLR5
4
Show member pathways
12.3 IL1B TLR2 TLR4 TLR5
5
Show member pathways
12.17 TLR2 TLR4 TLR5
6
Show member pathways
12.11 IL1B TLR2 TLR5
7
Show member pathways
12.05 TLR2 TLR4 TLR5
8
Show member pathways
12.03 IL1B TLR2 TLR4
9 12 IL1B TLR2 TLR4
10
Show member pathways
11.99 IL1B TLR2 TLR5
11
Show member pathways
11.96 IL1B TLR2 TLR4 TLR5
12 11.94 TLR2 TLR4 TLR5
13
Show member pathways
11.81 IL1B TLR2 TLR4
14
Show member pathways
11.78 IL1B TLR2 TLR4 TLR5
15 11.65 IL1B TLR2 TLR4
16 11.61 IL1B TLR2 TLR4
17
Show member pathways
11.57 IL1B TLR2 TLR4 TLR5
18 11.54 IL1B TLR4 TLR5
19 11.51 TLR2 TLR4 TLR5
20
Show member pathways
11.35 IL1B TLR2 TLR4 TLR5
21 11.23 IL1B TLR2 TLR4
22 11.18 IL1B TLR2 TLR4
23 11.16 IL1B TLR4
24 11 IL1B TLR2
25 10.66 IL1B TLR2 TLR4 TLR5

GO Terms for Suppurative Otitis Media

Cellular components related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic component of plasma membrane GO:0031226 8.62 TLR2 TLR4

Biological processes related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.87 CRP TLR2 TLR4 TLR5
2 positive regulation of gene expression GO:0010628 9.83 CRP IL1B TLR2 TLR4
3 response to lipopolysaccharide GO:0032496 9.76 IL1B TLR2 TLR4
4 cellular response to lipopolysaccharide GO:0071222 9.75 IL1B TLR4 TLR5
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 IL1B TLR2 TLR4
6 cellular response to mechanical stimulus GO:0071260 9.67 IL1B TLR4 TLR5
7 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B TLR2 TLR4
8 positive regulation of tumor necrosis factor production GO:0032760 9.63 TLR2 TLR4
9 positive regulation of interferon-gamma production GO:0032729 9.62 IL1B TLR4
10 toll-like receptor signaling pathway GO:0002224 9.62 TLR2 TLR4
11 positive regulation of interferon-beta production GO:0032728 9.61 TLR2 TLR4
12 positive regulation of interleukin-12 production GO:0032735 9.61 TLR2 TLR4
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.61 IL1B TLR2 TLR4
14 positive regulation of interleukin-10 production GO:0032733 9.6 TLR2 TLR4
15 positive regulation of chemokine production GO:0032722 9.59 TLR2 TLR4
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IL1B TLR4 TLR5
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.55 TLR2 TLR4
18 inflammatory response GO:0006954 9.55 CRP IL1B TLR2 TLR4 TLR5
19 I-kappaB phosphorylation GO:0007252 9.54 TLR2 TLR4
20 cellular response to lipoteichoic acid GO:0071223 9.51 TLR2 TLR4
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.5 IL1B TLR2 TLR4
22 positive regulation of toll-like receptor signaling pathway GO:0034123 9.46 TLR2 TLR5
23 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.43 TLR2 TLR4 TLR5
24 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.37 TLR2 TLR4
25 regulation of cytokine secretion GO:0050707 9.13 TLR2 TLR4 TLR5
26 positive regulation of interleukin-8 production GO:0032757 8.92 IL1B TLR2 TLR4 TLR5

Molecular functions related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR5
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Suppurative Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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