MCID: SPP008
MIFTS: 51

Suppurative Otitis Media

Categories: Ear diseases

Aliases & Classifications for Suppurative Otitis Media

MalaCards integrated aliases for Suppurative Otitis Media:

Name: Suppurative Otitis Media 12 15 73
Otitis Media with Effusion - Purulent 12
Otitis Media, Suppurative 44
Purulent Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11506
ICD9CM 35 382 382.4
MeSH 44 D010035
SNOMED-CT 68 38394007 39288006
UMLS 73 C0029888

Summaries for Suppurative Otitis Media

Disease Ontology : 12 A otitis media which involves inflammation of the middle ear with infected effusion containing pus.

MalaCards based summary : Suppurative Otitis Media, also known as otitis media with effusion - purulent, is related to chronic purulent otitis media and otitis media. An important gene associated with Suppurative Otitis Media is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Dexamethasone acetate and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and testes, and related phenotypes are digestive/alimentary and hematopoietic system

Related Diseases for Suppurative Otitis Media

Diseases related to Suppurative Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 chronic purulent otitis media 33.4 HSF4 TLR9 WIPF1
2 otitis media 33.2 IL1B TLR2 TLR4
3 mastoiditis 30.5 CRP SLC29A3
4 meningitis 30.5 CRP IL1B TLR2 TLR9
5 mesenteric lymphadenitis 30.3 CRP TLR2
6 appendicitis 30.1 CRP IL1B
7 tonsillitis 29.9 IL1B TLR9
8 bacterial meningitis 29.8 CRP IL1B TLR2 TLR9
9 pneumonia 29.4 CRP IL1B TLR2 TLR4 TLR5 TLR9
10 chronic tubotympanic suppurative otitis media 12.8
11 non-suppurative otitis media 12.7
12 purulent acute otitis media 12.3
13 chronic atticoantral disease 12.0
14 serous glue ear 11.6
15 acute serous otitis media 11.5
16 focal labyrinthitis 11.4
17 eustachian tube disease 11.4
18 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
19 thrombosis 10.4
20 sensorineural hearing loss 10.4
21 lateral sinus thrombosis 10.3
22 trench fever 10.2 TLR2 TLR4
23 fungal keratitis 10.2 TLR2 TLR4
24 acute cervicitis 10.2 TLR2 TLR4
25 anterior uveitis 10.2 TLR2 TLR4
26 penicilliosis 10.2 TLR2 TLR4
27 campylobacteriosis 10.2 IL1B TLR4
28 periodontitis, chronic 10.2 IL1B TLR2
29 cleft palate, isolated 10.2
30 allergic rhinitis 10.2
31 inflammatory myofibroblastic tumor 10.2
32 otosclerosis 10.2
33 facial paralysis 10.2
34 labyrinthitis 10.2
35 rhinitis 10.2
36 otitis externa 10.2
37 perilymphatic fistula 10.2
38 spondylarthropathy 10.2 TLR2 TLR4
39 neisseria meningitidis infection 10.2 TLR2 TLR4
40 haemophilus influenzae 10.2 IL1B TLR2
41 endometrial disease 10.2 IL1B TLR4
42 congenital cytomegalovirus 10.2 IL1B TLR2
43 cysticercosis 10.2 IL1B TLR4
44 alveolar echinococcosis 10.2 TLR2 TLR4
45 periapical periodontitis 10.2 IL1B TLR2
46 echinococcosis 10.2 TLR2 TLR4
47 primary systemic mycosis 10.2 IL1B TLR2
48 dental abscess 10.2 CRP TLR4
49 pyelitis 10.2 CRP TLR4
50 pericoronitis 10.2 CRP IL1B

Graphical network of the top 20 diseases related to Suppurative Otitis Media:



Diseases related to Suppurative Otitis Media

Symptoms & Phenotypes for Suppurative Otitis Media

MGI Mouse Phenotypes related to Suppurative Otitis Media:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.55 TLR2 TLR4 TLR5 TLR9 WIPF1
2 hematopoietic system MP:0005397 9.5 IL1B SLC29A3 TLR2 TLR4 TLR5 TLR9
3 immune system MP:0005387 9.23 CRP IL1B SLC29A3 TLR2 TLR4 TLR5

Drugs & Therapeutics for Suppurative Otitis Media

Drugs for Suppurative Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
5 Anti-Infective Agents Phase 4,Phase 1,Not Applicable
6 Anti-Bacterial Agents Phase 4,Phase 1,Not Applicable
7 Topoisomerase Inhibitors Phase 4,Phase 1
8 Cytochrome P-450 Enzyme Inhibitors Phase 4,Not Applicable
9 Expectorants Phase 4
10 Gastrointestinal Agents Phase 4
11 Hormones Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Protective Agents Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Pharmaceutical Solutions Phase 4
16 Antiemetics Phase 4
17 Free Radical Scavengers Phase 4
18 HIV Protease Inhibitors Phase 4
19 N-monoacetylcystine Phase 4
20 Antioxidants Phase 4
21 Antiviral Agents Phase 4
22 Hormone Antagonists Phase 4
23
protease inhibitors Phase 4
24 Respiratory System Agents Phase 4
25 BB 1101 Phase 4
26 Peripheral Nervous System Agents Phase 4,Not Applicable
27 glucocorticoids Phase 4
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
29 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
30 Antidotes Phase 4
31 Autonomic Agents Phase 4
32 Pazufloxacin Investigational Phase 1 127045-41-4
33 Antitubercular Agents Phase 1
34 Nucleic Acid Synthesis Inhibitors Phase 1
35 Fluoroquinolones Phase 1
36
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
37
leucovorin Approved Not Applicable 58-05-9 6006 143
38
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
39
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
40 Trimethoprim, Sulfamethoxazole Drug Combination Not Applicable
41 Folic Acid Antagonists Not Applicable
42 Vitamin B Complex Not Applicable
43 Antimalarials Not Applicable
44 Folate Not Applicable
45 Antiprotozoal Agents Not Applicable
46 Renal Agents Not Applicable
47 Anti-Infective Agents, Urinary Not Applicable
48 Vitamin B9 Not Applicable
49 Antiparasitic Agents Not Applicable
50 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media Unknown status NCT00271778 Phase 3
3 Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection
4 Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media Recruiting NCT03675841 Phase 1 Pazufloxacin Mesilate ear drops
5 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi Unknown status NCT02779907
6 Host-pathogen Interaction in Otitis Media Unknown status NCT00847756
7 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Not Applicable Sulfamethoxazole-trimethoprim;Placebo
8 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Not yet recruiting NCT03456739
9 Evaluation of Prognostic Factors in Tympanoplasty Not yet recruiting NCT03416725
10 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Not yet recruiting NCT02716376 Not Applicable
11 Preemptive Pregabalin in Myringoplasty Withdrawn NCT03603626 Not Applicable Pregabalin 150mg;Placebo oral capsule

Search NIH Clinical Center for Suppurative Otitis Media

Cochrane evidence based reviews: otitis media, suppurative

Genetic Tests for Suppurative Otitis Media

Anatomical Context for Suppurative Otitis Media

MalaCards organs/tissues related to Suppurative Otitis Media:

41
Bone, Brain, Testes, Lung, Lymph Node, Tonsil, Placenta

Publications for Suppurative Otitis Media

Articles related to Suppurative Otitis Media:

(show top 50) (show all 598)
# Title Authors Year
1
The Value of Diffusion-Weighted MRI in the Long-term follow-up After Subtotal Petrosectomy for Extensive Cholesteatoma and Chronic Suppurative Otitis Media. ( 30531639 )
2019
2
Risk factors of sensorineural hearing loss in patients with unilateral safe chronic suppurative otitis media. ( 29331307 )
2018
3
To Evaluate and Compare the Result of Ossiculoplasty Using Different Types of Graft Materials and Prosthesis in Cases of Ossicular Discontinuity in Chronic Suppurative Otitis Media Cases. ( 29456937 )
2018
4
The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media. ( 29951099 )
2018
5
Efficacy of Boric Acid as a Treatment of Choice for Chronic Suppurative Otitis Media and Its Ototoxicity. ( 29383205 )
2018
6
Fungal Suppurative Otitis Media (Histopathology) Among Patients in North India. ( 29671212 )
2018
7
Development of an ear cap in chronic suppurative otitis media using additive manufacturing and TRIZ. ( 29916767 )
2018
8
Aerobic bacteria associated with chronic suppurative otitis media in Angola. ( 29720274 )
2018
9
Efficacy of Empirical Therapy With Combined Ciprofloxacin Versus Topical Drops Alone in Patients With Tubotympanic Chronic Suppurative Otitis Media: A Randomized Double-Blind Controlled Trial. ( 29348711 )
2018
10
Shewanella algae in a chronic suppurative otitis media patient with cholesteatoma. ( 29681564 )
2018
11
Gradenigo Syndrome Induced by Suppurative Otitis Media. ( 29894453 )
2018
12
Development and Administration of Chronic Suppurative Otitis Media Questionnaire-12 (COMQ-12) and Chronic Otitis Media Outcome Test-15 (COMOT-15) in Kannada. ( 29619096 )
2018
13
Management of Chronic Suppurative Otitis Media and Otosclerosis in Developing Countries. ( 29525390 )
2018
14
A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media. ( 29151379 )
2018
15
Implementation and results of a surgical training programme for chronic suppurative otitis media in Cambodia. ( 29998817 )
2018
16
Citric Acid as an Alternative to Boric Acid in the Treatment of Chronic Suppurative Otitis Media. ( 30049178 )
2018
17
Causes of Delayed Care Seeking for Chronic Suppurative Otitis Media at a Rwandan Tertiary Hospital. ( 30057615 )
2018
18
Effectiveness of Type I Tympanoplasty in Wet and Dry Ear in Safe Chronic Suppurative Otitis Media. ( 30211083 )
2018
19
Comment to Empirical Therapy for Chronic Suppurative Otitis Media. ( 30479492 )
2018
20
Three cases of Chronic Suppurative Otitis Media (CSOM) caused by Kerstersia gyiorum and a review of the literature. ( 30555142 )
2018
21
Is Routine Use of High Resolution Computerized Tomography of Temporal Bone in Patients of Atticoantral Chronic Suppurative Otitis Media without Intracranial Complications Justified? ( 29456948 )
2018
22
Quality of life measurements for patients with chronic suppurative otitis media: Italian adaptation of "Chronic Ear Survey". ( 28374871 )
2017
23
[The influence of interleukin gene polymorphism on the serum cytokine level in the patients presenting with chonic suppurative otitis media]. ( 28631672 )
2017
24
High-frequency conductive hearing loss as a diagnostic test for incomplete ossicular discontinuity in non-cholesteatomatous chronic suppurative otitis media. ( 29267386 )
2017
25
Mycology of chronic suppurative otitis media-cholesteatoma disease: An evaluative study. ( 29306568 )
2017
26
Sensorineural hearing loss in patients with chronic suppurative otitis media: Is there a significant correlation? ( 28465813 )
2017
27
Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up. ( 29071059 )
2017
28
Impact of Chronic Suppurative Otitis Media in Pediatric Cochlear Implant Recipients-Insight into the Challenges from a Tertiary Referral Center in UK. ( 28333779 )
2017
29
Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link? ( 28466356 )
2017
30
Facial Nerve Paralysis in Acute Suppurative Otitis Media-Management. ( 28239580 )
2017
31
Comparative Evaluation of Tympanoplasty with or Without Mastoidectomy in Treatment of Chronic Suppurative Otitis Media Tubotympanic Type. ( 28607885 )
2017
32
Prevalence of paediatric chronic suppurative otitis media and hearing impairment in rural Malawi: A cross-sectional survey. ( 29267304 )
2017
33
Central Nervous System Inflammatory Myofibroblastic Tumor Masquerading as Chronic Suppurative Otitis Media. ( 28904584 )
2017
34
Fluoroquinolone-Resistant Alcaligenes faecalis Related to Chronic Suppurative Otitis Media, Angola. ( 28930018 )
2017
35
Gradenigo's Syndrome in a Patient with Chronic Suppurative Otitis Media, Petrous Apicitis, and Meningitis. ( 28955030 )
2017
36
Microbiology of Chronic Suppurative Otitis Media in a Tertiary Care Hospital in Bangladesh. ( 28919615 )
2017
37
Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media. ( 27177975 )
2016
38
Evaluation of Role of Mastoid Surgery in the Management of Safe Chronic Suppurative Otitis Media. ( 27833868 )
2016
39
Molecular Microbiological Profile of Chronic Suppurative Otitis Media. ( 27487953 )
2016
40
Changes in antibiotic resistance in recurrent Pseudomonas aeruginosa infections of chronic suppurative otitis media. ( 27792822 )
2016
41
Chronic Suppurative Otitis Media Complicated With Mastoiditis: An Unusual Presentation of Tuberculosis. ( 27865308 )
2016
42
Etiological factors associated with chronic suppurative otitis media in a population of Han adults in China. ( 27206699 )
2016
43
Predictors of disease complications and treatment outcome among patients with chronic suppurative otitis media attending a tertiary hospital, Mwanza Tanzania. ( 26766925 )
2016
44
Preoperative Predictors in Chronic Suppurative Otitis Media for Ossicular Chain Discontinuity: A Cross-Sectional Study. ( 27490829 )
2016
45
Do tissue spears used to clear ear canal pus improve hearing? A case series study of hearing in remote Australian Aboriginal children with chronic suppurative otitis media before and after dry mopping with tissue spears. ( 26685792 )
2016
46
Characterization of the T-cell subpopulations in the granulation tissues of chronic suppurative otitis media. ( 27313854 )
2016
47
Prevalence and associated factors of chronic suppurative otitis media: Data from the Korea National Health and Nutrition Examination Survey, 2009-2012. ( 27076099 )
2016
48
Frequency of Sensorineural hearing loss in chronic suppurative otitis media. ( 27895351 )
2016
49
Chronic suppurative otitis media, middle ear pathology and corresponding hearing loss in a cohort of Greenlandic children. ( 26968069 )
2016
50
Aspergillus fumigatus carrying TR34/L98H resistance allele causing complicated suppurative otitis media in Tanzania: Call for improved diagnosis of fungi in sub-Saharan Africa. ( 27589956 )
2016

Variations for Suppurative Otitis Media

Expression for Suppurative Otitis Media

Search GEO for disease gene expression data for Suppurative Otitis Media.

Pathways for Suppurative Otitis Media

Pathways related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 CRP IL1B TLR2 TLR4 TLR5 TLR9
2
Show member pathways
13.18 IL1B TLR2 TLR4 TLR5 TLR9
3
Show member pathways
12.99 IL1B TLR2 TLR4 TLR5 TLR9
4
Show member pathways
12.79 IL1B TLR2 TLR4 TLR5 TLR9
5
Show member pathways
12.59 IL1B TLR2 TLR4 TLR9
6
Show member pathways
12.42 IL1B TLR2 TLR4 TLR5 TLR9
7
Show member pathways
12.41 IL1B TLR2 TLR4 TLR5
8
Show member pathways
12.36 IL1B TLR2 TLR4 TLR5 TLR9
9
Show member pathways
12.22 TLR2 TLR4 TLR5 TLR9
10
Show member pathways
12.14 IL1B TLR2 TLR5
11
Show member pathways
12.07 TLR2 TLR4 TLR5 TLR9
12
Show member pathways
12.06 IL1B TLR2 TLR4
13
Show member pathways
12.03 IL1B TLR2 TLR5
14
Show member pathways
12.03 IL1B TLR2 TLR4 TLR5 TLR9
15 12.03 IL1B TLR2 TLR4 TLR9
16 11.98 TLR2 TLR4 TLR5 TLR9
17
Show member pathways
11.87 IL1B TLR2 TLR4
18
Show member pathways
11.77 IL1B TLR2 TLR4 TLR5 TLR9
19 11.74 IL1B TLR2 TLR4
20 11.7 IL1B TLR2 TLR4
21 11.67 IL1B TLR4 TLR5
22 11.6 TLR2 TLR4 TLR5 TLR9
23
Show member pathways
11.47 IL1B TLR2 TLR4 TLR5 TLR9
24 11.37 IL1B TLR2 TLR4
25 11.36 IL1B TLR2 TLR4 TLR5
26 11.25 IL1B TLR2 TLR4 TLR9
27 11.19 IL1B TLR9
28 11.19 IL1B TLR4
29
Show member pathways
11.11 IL1B TLR2 TLR4 TLR5 TLR9
30 11.02 IL1B TLR2

GO Terms for Suppurative Otitis Media

Cellular components related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic component of plasma membrane GO:0031226 8.96 TLR2 TLR4
2 cytoplasmic vesicle GO:0031410 8.92 IL1B TLR2 TLR9 WIPF1

Biological processes related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.99 CRP TLR2 TLR4 TLR5 TLR9
2 immune system process GO:0002376 9.97 TLR2 TLR4 TLR5 TLR9
3 immune response GO:0006955 9.96 IL1B TLR2 TLR4 TLR9
4 positive regulation of gene expression GO:0010628 9.95 CRP IL1B TLR2 TLR4 TLR9
5 defense response to bacterium GO:0042742 9.85 TLR4 TLR5 TLR9
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.85 IL1B TLR4 TLR9
7 response to lipopolysaccharide GO:0032496 9.84 IL1B TLR2 TLR4
8 cellular response to lipopolysaccharide GO:0071222 9.84 IL1B TLR4 TLR5
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 IL1B TLR2 TLR4 TLR9
10 positive regulation of JNK cascade GO:0046330 9.8 IL1B TLR4 TLR9
11 cellular response to mechanical stimulus GO:0071260 9.8 IL1B TLR4 TLR5
12 inflammatory response GO:0006954 9.8 CRP IL1B TLR2 TLR4 TLR5 TLR9
13 positive regulation of inflammatory response GO:0050729 9.79 TLR2 TLR4 TLR9
14 positive regulation of tumor necrosis factor production GO:0032760 9.77 TLR2 TLR4 TLR9
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IL1B TLR4 TLR5
16 toll-like receptor signaling pathway GO:0002224 9.75 TLR2 TLR4 TLR9
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 IL1B TLR2 TLR4
18 positive regulation of interleukin-6 production GO:0032755 9.71 IL1B TLR2 TLR4 TLR9
19 positive regulation of interferon-beta production GO:0032728 9.7 TLR2 TLR4 TLR9
20 positive regulation of interferon-gamma production GO:0032729 9.69 IL1B TLR4
21 positive regulation of interleukin-12 production GO:0032735 9.69 TLR2 TLR4 TLR9
22 positive regulation of JUN kinase activity GO:0043507 9.68 IL1B TLR9
23 positive regulation of B cell proliferation GO:0030890 9.68 TLR4 TLR9
24 negative regulation of interleukin-6 production GO:0032715 9.68 TLR4 TLR9
25 positive regulation of interleukin-10 production GO:0032733 9.67 TLR2 TLR4 TLR9
26 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.67 IL1B TLR2 TLR4 TLR9
27 response to molecule of bacterial origin GO:0002237 9.65 TLR2 TLR9
28 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.65 IL1B TLR9
29 positive regulation of chemokine production GO:0032722 9.65 TLR2 TLR4 TLR9
30 cellular response to lipoteichoic acid GO:0071223 9.64 TLR2 TLR4
31 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.64 TLR4 TLR9
32 positive regulation of interferon-beta biosynthetic process GO:0045359 9.63 TLR4 TLR9
33 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 TLR2 TLR4 TLR9
34 positive regulation of interleukin-18 production GO:0032741 9.61 TLR2 TLR9
35 tumor necrosis factor production GO:0032640 9.61 TLR2 TLR9
36 I-kappaB phosphorylation GO:0007252 9.61 TLR2 TLR4 TLR9
37 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.57 TLR2 TLR4
38 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.56 TLR2 TLR4 TLR5 TLR9
39 positive regulation of toll-like receptor signaling pathway GO:0034123 9.33 TLR2 TLR5 TLR9
40 regulation of cytokine secretion GO:0050707 9.26 TLR2 TLR4 TLR5 TLR9
41 positive regulation of interleukin-8 production GO:0032757 9.02 IL1B TLR2 TLR4 TLR5 TLR9
42 positive regulation of transcription by RNA polymerase II GO:0045944 10.06 HSF4 IL1B TLR2 TLR4 TLR9

Molecular functions related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.43 TLR4 TLR5 TLR9
2 lipopolysaccharide binding GO:0001530 9.32 TLR2 TLR4
3 signaling pattern recognition receptor activity GO:0008329 9.16 TLR2 TLR9
4 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4
5 interleukin-1 receptor binding GO:0005149 8.8 IL1B TLR5 TLR9

Sources for Suppurative Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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