MCID: SPP008
MIFTS: 42

Suppurative Otitis Media

Categories: Ear diseases

Aliases & Classifications for Suppurative Otitis Media

MalaCards integrated aliases for Suppurative Otitis Media:

Name: Suppurative Otitis Media 12 15 17 70
Otitis Media with Effusion - Purulent 12
Otitis Media, Suppurative 44
Purulent Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11506
ICD9CM 34 382.4
MeSH 44 D010035
SNOMED-CT 67 267758003
ICD10 32 H66 H66.4
UMLS 70 C0029888

Summaries for Suppurative Otitis Media

Disease Ontology : 12 A otitis media which involves inflammation of the middle ear with infected effusion containing pus.

MalaCards based summary : Suppurative Otitis Media, also known as otitis media with effusion - purulent, is related to otitis media and chronic purulent otitis media. An important gene associated with Suppurative Otitis Media is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Th17 cell differentiation and TRAF Pathway. The drugs Amoxicillin and Telithromycin have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and temporal lobe, and related phenotypes are hearing/vestibular/ear and immune system

Related Diseases for Suppurative Otitis Media

Diseases related to Suppurative Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 otitis media 31.9 TLR4 TLR2 IL1B FBXO11 EYA4 CRP
2 chronic purulent otitis media 31.1 TLR4 TLR2 MECOM FBXO11 EYA4 DRC1
3 mastoiditis 31.1 DOCK8 DHRS2 CRP
4 meningitis 31.0 TLR4 TLR2 IL1B CRP
5 otitis externa 30.8 DOCK8 CRP
6 osteomyelitis 30.7 TLR4 TLR2 IL1B CRP
7 arachnoiditis 30.6 IL1B CRP
8 mesenteric lymphadenitis 30.6 IL1B CRP
9 bacterial infectious disease 30.5 TLR5 TLR4 TLR2 IL1B CRP
10 measles 30.5 TLR4 TLR2 IL1B
11 bacterial meningitis 30.5 TLR4 TLR2 IL1B CRP
12 tonsillitis 30.5 TLR4 TLR2 IL1B
13 disease by infectious agent 30.5 TLR4 TLR2 IL1B CRP
14 appendicitis 30.4 TLR4 IL1B CRP
15 nose disease 30.4 TLR4 IL1B CRP
16 lymphadenitis 30.4 TLR4 IL1B CRP
17 middle ear disease 29.2 TLR4 TLR2 IL1B FBXO11 EYA4 DHRS2
18 purulent acute otitis media 11.8
19 chronic tubotympanic suppurative otitis media 11.8
20 non-suppurative otitis media 11.6
21 chronic atticoantral disease 11.6
22 serous glue ear 11.4
23 acute serous otitis media 11.4
24 focal labyrinthitis 11.3
25 eustachian tube disease 11.3
26 cholesteatoma of middle ear 11.1
27 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.9
28 sensorineural hearing loss 10.7
29 branchiootic syndrome 1 10.6
30 facial paralysis 10.6
31 labyrinthitis 10.6
32 otosclerosis 10.5
33 haemophilus influenzae 10.5
34 lateral sinus thrombosis 10.5
35 thrombophlebitis 10.5
36 tympanosclerosis 10.4
37 auditory system disease 10.4
38 perilymphatic fistula 10.4
39 otomycosis 10.4
40 thrombosis 10.4
41 discharging ear 10.4
42 cellulitis 10.4
43 fungal keratitis 10.4 TLR4 TLR2
44 anaerobic pneumonia 10.4 TLR2 IL1B
45 pathologic nystagmus 10.4
46 urinary tract infection 10.3 TLR4 CRP
47 periapical periodontitis 10.3 TLR2 IL1B
48 uremic pruritus 10.3 IL1B CRP
49 renal infectious disease 10.3 TLR2 CRP
50 pericoronitis 10.3 IL1B CRP

Graphical network of the top 20 diseases related to Suppurative Otitis Media:



Diseases related to Suppurative Otitis Media

Symptoms & Phenotypes for Suppurative Otitis Media

MGI Mouse Phenotypes related to Suppurative Otitis Media:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.43 BPIFA1 EYA4 FBXO11 FOXN1 MECOM TLR4
2 immune system MP:0005387 9.4 BPIFA1 CRP DOCK8 DRC1 EYA4 FBXO11

Drugs & Therapeutics for Suppurative Otitis Media

Drugs for Suppurative Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
2
Telithromycin Approved Phase 3 191114-48-4 5462516 70789201
3
Azithromycin Approved Phase 3 83905-01-5 447043 55185
4 Amoxicillin-Potassium Clavulanate Combination Phase 3
5 Clavulanic Acids Phase 3
6 beta-Lactamase Inhibitors Phase 3
7
carbamide peroxide Approved Phase 1 124-43-6
8
Pazufloxacin Investigational Phase 1 127045-41-4
9 Anti-Infective Agents, Local Phase 1
10 Antitubercular Agents Phase 1
11 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Withdrawn NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 Oral Amoxicillin-clavulanate in Treating Acute Otitis Media in Children: Randomized Double-blind Placebo-controlled Study Including Daily Monitoring With Tympanometry Completed NCT01244581 Phase 3 Amoxicillin-clavulanate;Placebo
3 Multinational, Randomized, Double-Blind, Double-Dummy, Comparative Study to Evaluate the Efficacy and Safety of 5 Days Telithromycin 25mg/kg od Versus 5 Days Azithromycin 10 mg/kg od Followed by 5 mg/kg od for 4 Days, in Children With Acute Otitis Media Terminated NCT00315003 Phase 3 Telithromycin;Azithromycin
4 A Phase I,Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media Unknown status NCT03675841 Phase 1 Pazufloxacin Mesilate ear drops
5 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in a Rural District of Malawi: A Cross-sectional Survey Unknown status NCT02779907
6 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Media in Pediatric Patients in Northern Israel Unknown status NCT03456739
7 Evaluation of Vestibular Function in Patients With Chronic Suppurative Otitis Media: Safe Type Recruiting NCT04791930
8 Assessment of an App Based on Artificial Intelligence for Purulent Acute Otitis Media (AOM) Diagnosis in a a Pediatric Emergency Department Not yet recruiting NCT04752891
9 Effect of Preemptive Pregabalin for Post-operative Pain Relief in Myringoplasty Withdrawn NCT03603626 Pregabalin 150mg;Placebo oral capsule

Search NIH Clinical Center for Suppurative Otitis Media

Cochrane evidence based reviews: otitis media, suppurative

Genetic Tests for Suppurative Otitis Media

Anatomical Context for Suppurative Otitis Media

MalaCards organs/tissues related to Suppurative Otitis Media:

40
Bone, Brain, Temporal Lobe, Skin, Tonsil, Eye, Cerebellum

Publications for Suppurative Otitis Media

Articles related to Suppurative Otitis Media:

(show top 50) (show all 2064)
# Title Authors PMID Year
1
Acute otitis media and pneumococcal vaccination - an observational cross-sectional study of otitis media among vaccinated and unvaccinated children in Greenland. 61
33407056 2021
2
Outcome of surgery for chronic suppurative otitis media with resistant Pseudomonas aeruginosa. 61
32583180 2021
3
[Quality of life assessment after endoscopic and microscopic myringoplasty using Chinese version of the Zurich chronic middle ear inventory]. 61
33794624 2021
4
Otitis media outcomes of a combined 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine and 13-valent pneumococcal conjugate vaccine schedule at 1-2-4-6 months: PREVIX_COMBO, a 3-arm randomised controlled trial. 61
33685411 2021
5
Humanized Anti-DNABII Fab Fragments Plus Ofloxacin Eradicated Biofilms in Experimental Otitis Media. 61
33666254 2021
6
Otitis media guidelines for Australian Aboriginal and Torres Strait Islander children: summary of recommendations. 61
33641192 2021
7
Comparison of Endoscopic Cartilage Myringoplasty in Dry and Wet Ears With Chronic Suppurative Otitis Media. 61
33719601 2021
8
Topical versus systemic antibiotics for chronic suppurative otitis media. 61
33561891 2021
9
Otolaryngeal and Oropharyngeal Conditions: Common Ear Conditions. 61
33595266 2021
10
[Transcanal endoscopic middle ear surgery in children with chronic suppurative otitis media]. 61
33720647 2021
11
Silencing Nrf2 attenuates chronic suppurative otitis media by inhibiting pro-inflammatory cytokine secretion through up-regulating TLR4. 61
32579053 2021
12
Primary bilateral tuberculous otitis media with peripheral facial paralysis: a case report and literature review. 61
33786147 2021
13
Investigating the use of a two-stage attention-aware convolutional neural network for the automated diagnosis of otitis media from tympanic membrane images: a prediction model development and validation study. 61
33478963 2021
14
Evaluation and comparison of tympanoplasty efficacy with tympanic membrane perforation after chronic suppurative otitis media in dry ear with different microorganisms. 61
33454455 2021
15
Quinine in Otology and Neurotology: Ototoxicity and Historic Role in Therapy. 61
33301286 2021
16
Diplopia in a Child: Gradenigo Syndrome Is an Unforgettable Disease. 61
33507110 2021
17
Retroauricular Abscess in Adults. 61
33605218 2021
18
A systematic review of the impact of cigarettes and electronic cigarettes in otology. 61
33272335 2020
19
Surgical outcomes of simultaneous cochlear implantation with subtotal petrosectomy. 61
32518029 2020
20
Subjective Visual Vertical Testing in Patients With Chronic Suppurative Otitis Media. 61
32571144 2020
21
Severe suppurative otitis media due to Streptococcus pneumoniae serotype 19A in a fully vaccinated infant by age. 61
32401687 2020
22
Management challenges at end-of-life in a patient with agitated delirium and benzodiazepine withdrawal at comprehensive cancer care center. 61
33222450 2020
23
Floating labyrinth: A unique finding on CT scan. 61
32944108 2020
24
Suppurative otitis media in Angola: clinical and demographic features. 61
32677730 2020
25
Follow up of a birth cohort to identify prevalence and risk factors for otitis media among Indian children in the eighth year of life. 61
32658800 2020
26
[The discussion on the application of simultaneous balloon Eustachian tuboplasty in the hearing reconstruction in patients with chronic suppurative otitis media]. 61
33254293 2020
27
Chronic suppurative otitis media in Zimbabwean school children: a cross-sectional study. 61
33016257 2020
28
[A prospective comparative study on the short-term effect of endoscopic myringoplasty in dry and wet ears]. 61
33254289 2020
29
Mucosal Type of Chronic Suppurative Otitis Media and the Long-Term Impact on Hearing Loss. 61
33029456 2020
30
Upper Respiratory Tract Microbiome and Otitis Media Intertalk: Lessons from the Literature. 61
32887458 2020
31
Tympanoplasty With or Without Balloon Eustachian Tuboplasty for Chronic Suppurative Otitis Media With Obstructive Eustachian Tube Dysfunction. 61
32472920 2020
32
Aural toilet (ear cleaning) for chronic suppurative otitis media. 61
32926406 2020
33
[Clinical research advances of endoscopic tympanoplasty]. 61
33040515 2020
34
Analysis of main pathogenic bacteria and drug sensitivity in patients with chronic suppurative otitis media and middle ear cholesteatoma in China. 61
32270423 2020
35
A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation. 61
32851190 2020
36
High-resolution computed tomography (HRCT) in pediatric and adult patients with unsafe chronic suppurative otitis media (CSOM) and its surgical correlation. 61
33110811 2020
37
Causality of Chronic Suppurative Otitis Media: An Observational Study. 61
32953341 2020
38
Analysis on the correlation between Eustachian tube function and outcomes of type I tympanoplasty for chronic suppurative otitis media. 61
32400245 2020
39
Poguntano effect on cell viability in cholesteatoma keratinocyte of chronic suppurative otitis media. 61
32662611 2020
40
Comprehensive Community Screening of Otological Patients by Trained Technicians Using a Telemedicine Device: An Efficient and Cost-Effective Way to Triage Patients With Ear Diseases. 61
32845807 2020
41
Use of a sternocleidomastoid rotational and cervical-fascial advancement flap for closure of a persistent mastoid cutaneous fistula. 61
32772935 2020
42
Unsolved problems and new medical approaches to otitis media. 61
32178551 2020
43
Tuberculous otitis media with osteomyelitis of the regional craniofacial bones. 61
32862169 2020
44
[Clinical analysis of complications of suppurative otitis media in children]. 61
32791630 2020
45
Bacteriology of Chronic Supporative Otitis Media (CSOM) at a Tertiary Care Hospital, Mymensingh. 61
32844792 2020
46
Chronic suppurative otitis media due to Streptomyces cacaoi, the second case report in human infection. 61
32652948 2020
47
Application of Enhanced Recovery After Surgery in Perioperative Period of Tympanoplasty and Mastoidectomy. 61
32551958 2020
48
[Patient-reported outcome measures as evaluation parameters in chronic suppurative otitis media]. 61
32842375 2020
49
Deep Learning in Automated Region Proposal and Diagnosis of Chronic Otitis Media Based on Computed Tomography. 61
31567561 2020
50
Management of Foreign Bodies in the Ear: A Retrospective Review of 123 Cases in Nigeria. 61
32396019 2020

Variations for Suppurative Otitis Media

Expression for Suppurative Otitis Media

Search GEO for disease gene expression data for Suppurative Otitis Media.

Pathways for Suppurative Otitis Media

Pathways related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.36 TLR5 TLR4 TLR2 IL1B
2
Show member pathways
12.34 TLR5 TLR4 TLR2 IL1B
3
Show member pathways
11.84 TLR5 TLR4 TLR2 IL1B
4 11.68 TLR4 TLR2 IL1B
5
Show member pathways
11.65 TLR5 TLR4 TLR2 IL1B
6 11.62 TLR4 TLR2 IL1B
7 11.56 TLR5 TLR4 TLR2
8 11.43 TLR5 TLR4 TLR2
9
Show member pathways
11.42 TLR5 TLR4 TLR2 IL1B
10 11.28 TLR4 TLR2 IL1B
11 11.23 TLR4 TLR2 IL1B
12
Show member pathways
11.14 TLR5 TLR4 TLR2 IL1B
13 10.68 TLR5 TLR4 TLR2 IL1B

GO Terms for Suppurative Otitis Media

Biological processes related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.97 TLR5 TLR4 TLR2 CRP BPIFA1
2 inflammatory response GO:0006954 9.85 TLR5 TLR4 TLR2 IL1B CRP
3 positive regulation of inflammatory response GO:0050729 9.73 TLR4 TLR2 IL1B
4 positive regulation of interleukin-6 production GO:0032755 9.71 TLR4 TLR2 IL1B
5 cellular response to mechanical stimulus GO:0071260 9.69 TLR5 TLR4 IL1B
6 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.65 TLR4 TLR2 IL1B
7 toll-like receptor signaling pathway GO:0002224 9.61 TLR5 TLR4 TLR2
8 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.58 TLR4 TLR2
9 I-kappaB phosphorylation GO:0007252 9.55 TLR4 TLR2
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 TLR5 TLR4 IL1B
11 cellular response to lipoteichoic acid GO:0071223 9.52 TLR4 TLR2
12 regulation of cytokine secretion GO:0050707 9.49 TLR5 TLR2
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 TLR4 TLR2 IL1B
14 positive regulation of toll-like receptor signaling pathway GO:0034123 9.4 TLR5 TLR2
15 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.33 TLR5 TLR4 TLR2
16 positive regulation of matrix metallopeptidase secretion GO:1904466 9.32 TLR4 TLR2
17 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 8.96 TLR4 TLR2
18 positive regulation of interleukin-8 production GO:0032757 8.92 TLR5 TLR4 TLR2 IL1B

Molecular functions related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.26 TLR4 TLR2
2 NAD(P)+ nucleosidase activity GO:0050135 9.16 TLR4 TLR2
3 interleukin-1 receptor binding GO:0005149 8.96 TLR5 IL1B
4 lipopolysaccharide receptor activity GO:0001875 8.62 TLR4 TLR2

Sources for Suppurative Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....