MCID: SPP003
MIFTS: 38

Suppurative Periapical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Suppurative Periapical Periodontitis

MalaCards integrated aliases for Suppurative Periapical Periodontitis:

Name: Suppurative Periapical Periodontitis 12 15 17 70
Periapical Abscess 12 54 44
Suppurative Apical Periodontitis 12
Dentoalveolar Abscess 12
Apical Abscess 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2562
MeSH 44 D010482
NCIt 50 C34913
SNOMED-CT 67 34597006
ICD10 32 K04.6 K04.7
UMLS 70 C0031024

Summaries for Suppurative Periapical Periodontitis

MalaCards based summary : Suppurative Periapical Periodontitis, also known as periapical abscess, is related to dental pulp necrosis and dental caries. An important gene associated with Suppurative Periapical Periodontitis is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Bacterial infections in CF airways and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Ciprofloxacin and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and heart.

Related Diseases for Suppurative Periapical Periodontitis

Diseases related to Suppurative Periapical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 409)
# Related Disease Score Top Affiliating Genes
1 dental pulp necrosis 30.5 IL1B DSPP
2 dental caries 30.2 DSPP CRP AMBN
3 pericoronitis 30.1 IL1B CRP
4 dental abscess 30.0 PHEX DSPP CRP
5 periodontitis, chronic 30.0 IL6 IL1B
6 cerebritis 30.0 IL1B CRP
7 periapical periodontitis 30.0 IL6 IL1B DSPP CXCL8
8 tonsillitis 29.9 IL6 IL1B CXCL8
9 pleural empyema 29.8 IL6 CRP
10 lymphadenitis 29.8 IL1B CXCL8 CRP
11 pulpitis 29.8 IL6 IL1B DSPP CXCL8
12 periodontitis 29.7 IL6 IL1B CXCL8 CRP
13 exanthem 29.4 IL6 IL1B CXCL8 CRP
14 skin disease 29.1 IL6 IL1B CXCL8 CRP
15 pulp degeneration 10.4 DSPP AMBN
16 hypercementosis 10.3 DSPP AMBN
17 tooth erosion 10.3 DSPP AMBN
18 acute pericementitis 10.2 IL1B CXCL8
19 trichodentoosseous syndrome 10.2 DSPP AMBN
20 baritosis 10.2 IL1B CXCL8
21 enterocolitis 10.2 IL6 CXCL8
22 physiological polycythemia 10.2 IL6 IL1B
23 tooth resorption 10.2 IL1B DSPP AMBN
24 indolent plasma cell myeloma 10.2 IL6 IL1B
25 tungiasis 10.2 IL1B CXCL8
26 idiopathic anterior uveitis 10.2 IL6 CXCL8
27 anaerobic pneumonia 10.2 IL6 IL1B
28 ulcer of lower limbs 10.2 IL6 IL1B
29 transient arthritis 10.2 IL6 IL1B
30 streptococcal toxic-shock syndrome 10.2 IL6 CXCL8
31 acute transverse myelitis 10.2 IL6 CXCL8
32 acute gonococcal cervicitis 10.2 IL6 CXCL8
33 fuchs' heterochromic uveitis 10.2 IL6 CXCL8
34 glomeruloid hemangioma 10.2 IL6 IL1B
35 epilepsy, familial temporal lobe, 2 10.1 IL6 DSPP
36 stachybotrys chartarum 10.1 IL6 IL1B
37 carbuncle 10.1 IL6 IL1B
38 eales disease 10.1 IL6 IL1B
39 traumatic brain injury 10.1 IL6 IL1B
40 acute monoblastic leukemia 10.1 IL6 CXCL8
41 brain injury 10.1 IL6 IL1B
42 denture stomatitis 10.1 IL6 CXCL8
43 progressive myoclonus epilepsy 8 10.1 IL6 CXCL8
44 arachnoiditis 10.1 IL1B CRP
45 diabetes mellitus, ketosis-prone 10.1
46 mesenteric lymphadenitis 10.1 IL1B CRP
47 teeth hard tissue disease 10.1 IL6 DSPP AMBN
48 slow-channel congenital myasthenic syndrome 10.1 CXCL8 CRP
49 aspiration pneumonitis 10.1 CXCL8 CRP
50 cardiac rupture 10.1 CXCL8 CRP

Graphical network of the top 20 diseases related to Suppurative Periapical Periodontitis:



Diseases related to Suppurative Periapical Periodontitis

Symptoms & Phenotypes for Suppurative Periapical Periodontitis

Drugs & Therapeutics for Suppurative Periapical Periodontitis

Drugs for Suppurative Periapical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
2
Metronidazole Approved Phase 4 443-48-1 4173
3
Ethanol Approved Phase 4 64-17-5 702
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
6
Lactitol Approved, Investigational Phase 4 585-86-4 157355
7 Antibiotics, Antitubercular Phase 4
8 Anti-Bacterial Agents Phase 4
9 Anti-Infective Agents Phase 4
10 Pharmaceutical Solutions Phase 4
11 Anesthetics Phase 4
12 Antiparasitic Agents Phase 4
13 Vasoconstrictor Agents Phase 4
14 Antiprotozoal Agents Phase 4
15 Propolis Phase 4
16 Bee Products Phase 4
17 Cytochrome P-450 Enzyme Inhibitors Phase 4
18
Chlorhexidine Approved, Vet_approved Phase 2, Phase 3 55-56-1 9552079 2713
19
Minocycline Approved, Investigational Phase 2, Phase 3 10118-90-8 5281021
20
Chitosan Experimental Phase 2, Phase 3 9012-76-4 71853
21 Dermatologic Agents Phase 2, Phase 3
22 Anti-Inflammatory Agents Phase 2, Phase 3
23 Anti-Infective Agents, Local Phase 2, Phase 3
24 Root Canal Irrigants Phase 2, Phase 3
25 Chlorhexidine gluconate Phase 2, Phase 3
26 Neem Phase 2, Phase 3
27 Calcium, Dietary Phase 2, Phase 3
28 Disinfectants Phase 2, Phase 3
29
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
30
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
31
Zinc oxide Approved Phase 2 1314-13-2
32
Zinc Approved, Investigational Phase 2 7440-66-6 32051
33 Protective Agents Phase 2
34 Radiation-Protective Agents Phase 2
35 Sunscreening Agents Phase 2
36
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
37
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
38
Acetaminophen Approved 103-90-2 1983
39
Guaifenesin Approved, Investigational, Vet_approved 93-14-1 3516
40
Tramadol Approved, Investigational 27203-92-5 33741
41
Codeine Approved, Illicit 76-57-3 5284371
42
Phenylpropanolamine Approved, Vet_approved, Withdrawn 14838-15-4 26934
43 Gastrointestinal Agents
44 Antiemetics
45 Hormones
46 Hormone Antagonists
47 glucocorticoids
48 Antineoplastic Agents, Hormonal
49 Respiratory System Agents
50 Analgesics, Non-Narcotic

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Comparative Randomized Clinical Trial of Three Endodontic Retrograde Filling Materials Completed NCT04198298 Phase 4 EndoSequence;ProRoot MTA;Biodentine
2 Efficiency of Triple Antibiotic Mixture and Propolis as Intracanal Medication in Revascularization Process in Immature Apex: A Clinical Study Completed NCT03533231 Phase 4
3 Resolution of Pain and Swelling After the Use of Neem Leaf Extract (Azadirachta Indica) Compared to Chlorhexidine Gluconate as an Intracanal Irrigant in Necrotic Primary Molar Teeth in Children Undergoing Pulpectomy Treatment: A Randomised Controlled Trial Completed NCT02943759 Phase 2, Phase 3 Neem leaf extract;Chlorhexidine gluconate
4 Clinical and Radiographic Comparative Evaluation of Healing of Periapical Lesion Using Triple Antibiotic Paste With Combination of Chitosan and Calcium Hydroxide When Used as a Root Canal Disinfectant- An In Vivo Study Recruiting NCT04319575 Phase 2, Phase 3 root canal treatment and intracanal medicament
5 Clinical, Microbiological and Quality of Life Outcomes Following Use of Systemic and Local Antimicrobials in the Management of Odontogenic Infections in Paediatric Patients Completed NCT03761264 Phase 2 Odontopaste®;Pulpdent;Amoxicillin
6 The Effects of Dexamethasone on the Time to Pain Resolution in Dental Periapical Abscess Unknown status NCT03005522 oral dexamethasone;Placebo Oral Capsule
7 Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess: A Randomized Clinical Trial Completed NCT02750696 Fixed-dose oral tablet of codeine/ acetaminophen every 4 hours for 3 days;Fixed-dose oral tablet of tramadol/ acetaminophen every 4 hours for 3 days
8 Root Canal Treatment of Compromised Teeth as Alternative Treatment in Patients Under Bisphosphonate Therapy: 60-month Results of a Prospective Clinical Study Completed NCT04399720
9 Assessment of C-reactive Protein Levels in Acute Apical Abscess Due to Root Canal Infection Recruiting NCT04684407

Search NIH Clinical Center for Suppurative Periapical Periodontitis

Cochrane evidence based reviews: periapical abscess

Genetic Tests for Suppurative Periapical Periodontitis

Anatomical Context for Suppurative Periapical Periodontitis

MalaCards organs/tissues related to Suppurative Periapical Periodontitis:

40
Bone, Brain, Heart, Liver, Lung, Skin, Eye

Publications for Suppurative Periapical Periodontitis

Articles related to Suppurative Periapical Periodontitis:

(show top 50) (show all 171)
# Title Authors PMID Year
1
Dentin malformation with alveolar bone loss and periapical abscess formation. 61 54
10197342 1999
2
Treatment Strategy for Odontogenic Sinusitis. 61
32722916 2021
3
The Effects of Dexamethasone on the Time to Pain Resolution in Dental Periapical Abscess. 61
33483197 2021
4
Chronic inflammatory periapical diseases: a Brazilian multicenter study of 10,381 cases and literature review. 61
33729278 2021
5
Assessment of dental pain in children with intellectual disability using the dental discomfort questionnaire. 61
33499707 2021
6
Diabetes Mellitus and Periapical Abscess: A Cross-sectional Study. 61
32827508 2020
7
Hospital Inpatient Admissions of Children and Adolescents for Nontraumatic Dental Conditions in Florida. 61
32522325 2020
8
Observation of an extracted premolar 2.5 years after mineral trioxide aggregate apexification using micro-computed tomography. 61
32483529 2020
9
Hospital use for non-traumatic dental conditions among older adults in Florida. 61
31774203 2020
10
Evaluation of canine teeth crown reduction technique in macaques. 61
32518764 2020
11
Guided endodontics: a case report of maxillary lateral incisors with multiple dens invaginatus. 61
31799166 2019
12
Primary molar with chronic periapical abscess showing atypical presentation of simultaneous extraoral and intraoral sinus tract with multiple stomata. 61
31511260 2019
13
Antibiotic Prescriptions Associated With Dental-Related Emergency Department Visits. 61
30392733 2019
14
Mesenchymal Stem Cell Marker Expression in Periapical Abscess. 61
31060815 2019
15
A retrospective analysis of hospitalisation for diseases of the pulp and periapical tissues in NHS Grampian 2011-2015: geographic, socioeconomic and increased primary care availability effects. 61
31253916 2019
16
Mediastinitis as complication of odontogenic infection: A case report. 61
31187775 2019
17
Hospital inpatient admissions for nontraumatic dental conditions among Florida adults, 2006 through 2016. 61
30955700 2019
18
Hospital-based Emergency Department Visits with Periapical Abscess: Updated Estimates from 7 Years. 61
30803531 2019
19
Development and evaluation of calcium hydroxide-coated, pericardium-based biomembranes for direct pulp capping. 61
30525301 2019
20
Epidemiological Profile of the Pathologies of the Oral Cavity in a Peruvian Population: A 9-Year Retrospective Study of 18,639 Patients. 61
30853862 2019
21
Opioid abuse/dependence among those hospitalized due to periapical abscess. 61
30066389 2018
22
Non-surgical endodontic management of immature permanent mandibular first molar: a 3 year follow-up. 61
30105499 2018
23
Cervicofacial Actinomycosis and its Management. 61
30693266 2018
24
Capnocytophaga endodontalis sp. nov., Isolated from a Human Refractory Periapical Abscess. 61
29181783 2018
25
Association between Apical Periodontitis and Interleukin Gene Polymorphisms: A Systematic Review and Meta-analysis. 61
29306532 2018
26
Fungal periapical abscess and the burn patient: A report of two cases of an unreported source for systemic infection. 61
28602586 2018
27
[The prognostication of development of peri-apical abscess under chronic periodontitis by blood parameters and cell immunity in children]. 61
30550088 2018
28
[Efficiency of chronic apical periodontitis treatment with use of Granulotec endodontic sealer]. 61
30589425 2018
29
Endodontic Management of a Chronic Periapical Abscess in a Maxillary Central Incisor with an Immature Root Apex Using Platelet-Rich Fibrin: A Case Report. 61
32161877 2018
30
Emergency department visits for dental problems not associated with trauma in Alberta, Canada. 61
28574193 2017
31
Management of Dens Invaginatus Type II Associated with Immature Apex and Large Periradicular Lesion Using Platelet-rich Fibrin and Biodentine. 61
28712634 2017
32
Association Between Apical Periodontitis and TNF-α -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis. 61
29215675 2017
33
Rational use of medicine in dentistry: do dentists prescribe antibiotics in appropriate indications? 61
28462430 2017
34
Arteriovenous Malformation of Face. 61
29042740 2017
35
Chondroblastic osteosarcoma mimicking periapical abscess. 61
28877285 2017
36
Differential diagnosis of periapical cyst using collagen birefringence pattern of the cyst wall. 61
28503476 2017
37
Impact of Periapical Abscess on Infectious Complications in Patients Undergoing Extracorporeal Circulation Auxiliary to Open-Heart Surgical Procedures. 61
28259310 2017
38
Role of Thr399Ile and Asp299Gly polymorphisms of toll-like receptor-4 gene in acute dental abscess. 61
28210435 2017
39
Odontogenic Orofacial Infections. 61
27930461 2017
40
Oxidative stress in patients with endodontic pathologies. 61
28894386 2017
41
Periapical abscess – etiology, pathogenesis and epidemiology 61
29186939 2017
42
Antibacterial Effect of Aloe Vera Gel against Oral Pathogens: An In-vitro Study. 61
28050502 2016
43
The root of the problem: Occurrence of typical and atypical periapical pathoses. 61
27046538 2016
44
Dentin Dysplasia in Notum Knockout Mice. 61
26926082 2016
45
Prevalence of several herpesviruses and human papillomavirus in acute apical abscesses. 61
26073223 2016
46
Diagnosis and Treatment of Odontogenic Cutaneous Sinus Tracts in an 11-Year-Old Boy: A Case Report. 61
27196471 2016
47
Antibiotic prescribing by dentists has increased: Why? 61
26857041 2016
48
A case of bacteremia caused by Dialister pneumosintes and Slackia exigua in a patient with periapical abscess. 61
26612007 2016
49
Analysis of Interleukin 17A in periapical abscess and granuloma lesions. 61
27050938 2016
50
Role of inflammation in developmental odontogenic pathosis. 61
27194886 2016

Variations for Suppurative Periapical Periodontitis

Expression for Suppurative Periapical Periodontitis

Search GEO for disease gene expression data for Suppurative Periapical Periodontitis.

Pathways for Suppurative Periapical Periodontitis

Pathways related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.96 IL6 IL1B CXCL8
2 11.94 IL6 IL1B CXCL8
3 11.86 IL6 IL1B CXCL8
4 11.79 IL6 IL1B CXCL8
5 11.76 IL6 IL1B CXCL8
6 11.71 IL6 IL1B CXCL8
7 11.66 IL6 IL1B CXCL8
8 11.63 IL6 IL1B CXCL8
9 11.58 IL6 IL1B CXCL8
10 11.46 IL6 IL1B CXCL8
11
Show member pathways
11.34 IL6 IL1B CXCL8
12 11.3 IL6 IL1B CXCL8
13 11.19 IL6 IL1B CXCL8
14 11.03 IL6 IL1B CXCL8
15 10.82 IL6 IL1B CXCL8
16 10.57 IL6 IL1B
17 10.08 CRP CXCL8 IL6

GO Terms for Suppurative Periapical Periodontitis

Cellular components related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 NOTUM MMP19 IL6 IL1B DSPP CXCL8

Biological processes related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.62 IL6 IL1B CXCL8 CRP
2 cellular response to lipopolysaccharide GO:0071222 9.58 IL6 IL1B CXCL8
3 positive regulation of glial cell proliferation GO:0060252 9.37 IL6 IL1B
4 positive regulation of neuroinflammatory response GO:0150078 9.26 IL6 IL1B
5 negative regulation of lipid storage GO:0010888 9.16 IL6 CRP
6 vascular endothelial growth factor production GO:0010573 8.96 IL6 IL1B
7 biomineral tissue development GO:0031214 8.8 PHEX DSPP AMBN

Sources for Suppurative Periapical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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