MCID: SPP003
MIFTS: 34

Suppurative Periapical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Suppurative Periapical Periodontitis

MalaCards integrated aliases for Suppurative Periapical Periodontitis:

Name: Suppurative Periapical Periodontitis 12 15 17 74
Periapical Abscess 12 56 45
Suppurative Apical Periodontitis 12
Dentoalveolar Abscess 12
Apical Abscess 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2562
MeSH 45 D010482
NCIt 51 C34913
SNOMED-CT 69 34597006
ICD10 34 K04.6 K04.7
UMLS 74 C0031024

Summaries for Suppurative Periapical Periodontitis

MalaCards based summary : Suppurative Periapical Periodontitis, also known as periapical abscess, is related to dental abscess and periodontitis. An important gene associated with Suppurative Periapical Periodontitis is PIMREG (PICALM Interacting Mitotic Regulator), and among its related pathways/superpathways is Matrix Metalloproteinases. The drugs Xylometazoline and Bacitracin have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Suppurative Periapical Periodontitis

Diseases related to Suppurative Periapical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 dental abscess 11.8
2 periodontitis 10.2
3 sinusitis 10.1
4 periapical periodontitis 10.1
5 maxillary sinusitis 10.0
6 burkitt lymphoma 10.0
7 hypochondroplasia 10.0
8 hypophosphatemic rickets, x-linked recessive 10.0
9 diabetes mellitus, ketosis-prone 10.0
10 polyarteritis nodosa, childhood-onset 10.0
11 lymphoma 10.0
12 rickets 10.0
13 acute lymphocytic leukemia 9.9
14 burns 9.9
15 leukemia 9.9
16 lymphocytic leukemia 9.9
17 opioid abuse 9.9
18 chondroblastic osteosarcoma 9.9
19 periodontal disease 9.9
20 acute apical periodontitis 9.8
21 gingivitis 9.7 CTSG LTF
22 cholangitis, primary sclerosing 9.6 CTSG LTF

Graphical network of the top 20 diseases related to Suppurative Periapical Periodontitis:



Diseases related to Suppurative Periapical Periodontitis

Symptoms & Phenotypes for Suppurative Periapical Periodontitis

MGI Mouse Phenotypes related to Suppurative Periapical Periodontitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.35 CHD7 CTSG GFI1 LTF MMP19
2 immune system MP:0005387 9.02 CHD7 CTSG GFI1 LTF MMP19

Drugs & Therapeutics for Suppurative Periapical Periodontitis

Drugs for Suppurative Periapical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
2
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
3
Neomycin Approved, Vet_approved Phase 4 1404-04-2 8378
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5
Ethanol Approved Phase 4 64-17-5 702
6
Polymyxin B Approved, Vet_approved Phase 4 1404-26-8
7
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
8
Metronidazole Approved Phase 4 443-48-1 4173
9
Amoxicillin Approved, Vet_approved Phase 4,Phase 2 26787-78-0 33613
10
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
11
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
12
Lactitol Investigational Phase 4 585-86-4, 585-88-6 493591
13 Anti-Infective Agents, Local Phase 4,Phase 2,Phase 3
14 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
15 Anti-Infective Agents Phase 4,Phase 2,Phase 3
16 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3
17 Cytochrome P-450 Enzyme Inhibitors Phase 4
18 Propolis Phase 4
19 Bee Products Phase 4
20 Vasoconstrictor Agents Phase 4
21 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
22 Anesthetics Phase 4
23 Antiparasitic Agents Phase 4
24 Polymyxins Phase 4
25 Topoisomerase Inhibitors Phase 4
26 Antibiotics, Antitubercular Phase 4
27 Antitubercular Agents Phase 4
28 Antiprotozoal Agents Phase 4
29 Clindamycin palmitate Phase 4
30 Clindamycin phosphate Phase 4
31 beta-Lactamase Inhibitors Phase 4
32 Amoxicillin-Potassium Clavulanate Combination Phase 4
33
Chlorhexidine Approved, Vet_approved Phase 2, Phase 3 55-56-1 2713 9552079
34 Neem Phase 2, Phase 3
35 Anti-Inflammatory Agents Phase 2, Phase 3,Not Applicable
36 Chlorhexidine gluconate Phase 2, Phase 3
37 Disinfectants Phase 2, Phase 3
38 Dermatologic Agents Phase 2, Phase 3
39 Root Canal Irrigants Phase 2, Phase 3
40
Zinc oxide Approved Phase 2 1314-13-2
41
Zinc Approved, Investigational Phase 2 7440-66-6 32051
42
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
43 Calcium, Dietary Phase 2
44
Codeine Approved, Illicit Not Applicable 76-57-3 5284371
45
Acetaminophen Approved Not Applicable 103-90-2 1983
46
Tramadol Approved, Investigational Not Applicable 27203-92-5 33741
47
Guaifenesin Approved, Investigational, Vet_approved Not Applicable 93-14-1 3516
48
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
49
Dexamethasone acetate Approved, Investigational, Vet_approved Not Applicable 1177-87-3
50 Analgesics, Opioid Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old. Completed NCT03533231 Phase 4
2 AUGMENTIN™ in Dental Infections Completed NCT02141217 Phase 4 Amoxicillin/clavulanate;Clindamycin
3 Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy Unknown status NCT02943759 Phase 2, Phase 3 Neem leaf extract;Chlorhexidine gluconate
4 Systemic and Local Antimicrobials in the Management of Dental Abscess in Children Recruiting NCT03761264 Phase 2 Odontopaste®;Pulpdent;Amoxicillin
5 Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess Completed NCT02750696 Not Applicable Fixed-dose oral tablet of codeine/ acetaminophen every 4 hours for 3 days;Fixed-dose oral tablet of tramadol/ acetaminophen every 4 hours for 3 days
6 Periodontal and Periapical Inflammation and Pregnancy Completed NCT00490165
7 The Effects of Dexamethasone on the Time to Pain Resolution in Dental Periapical Abscess Recruiting NCT03005522 Not Applicable oral dexamethasone;Placebo Oral Capsule
8 Clinical Applicability of PBSCIMMO as a Single Material in Endodontic Obturations Enrolling by invitation NCT03514264 Not Applicable

Search NIH Clinical Center for Suppurative Periapical Periodontitis

Cochrane evidence based reviews: periapical abscess

Genetic Tests for Suppurative Periapical Periodontitis

Anatomical Context for Suppurative Periapical Periodontitis

MalaCards organs/tissues related to Suppurative Periapical Periodontitis:

42
Bone

Publications for Suppurative Periapical Periodontitis

Articles related to Suppurative Periapical Periodontitis:

(show all 41)
# Title Authors Year
1
Hospital-based Emergency Department Visits with Periapical Abscess: Updated Estimates from 7 Years. ( 30803531 )
2019
2
Opioid abuse/dependence among those hospitalized due to periapical abscess. ( 30066389 )
2018
3
Fungal periapical abscess and the burn patient: A report of two cases of an unreported source for systemic infection. ( 28602586 )
2018
4
Capnocytophaga endodontalis sp. nov., Isolated from a Human Refractory Periapical Abscess. ( 29181783 )
2018
5
Chondroblastic osteosarcoma mimicking periapical abscess. ( 28877285 )
2017
6
Impact of Periapical Abscess on Infectious Complications in Patients Undergoing Extracorporeal Circulation Auxiliary to Open-Heart Surgical Procedures. ( 28259310 )
2017
7
Periapical abscess – etiology, pathogenesis and epidemiology ( 29186939 )
2017
8
A case of bacteremia caused by Dialister pneumosintes and Slackia exigua in a patient with periapical abscess. ( 26612007 )
2016
9
Analysis of Interleukin 17A in periapical abscess and granuloma lesions. ( 27050938 )
2016
10
A retrospective cohort study on the association between periapical abscess, advanced periodontal disease, and the national oral health screening program among Korean adults. ( 22186394 )
2013
11
Outcomes of hospitalizations attributed to periapical abscess from 2000 to 2008: a longitudinal trend analysis. ( 23953280 )
2013
12
Draft Genome Sequence of the Novel Peptoniphilus sp. Strain ChDC B134, Isolated from a Human Periapical Abscess Lesion. ( 24158551 )
2013
13
Nonsteroidal anti-inflammatory drugs misleading the diagnosis of periapical abscess. ( 22690058 )
2012
14
Periapical abscess. ( 21282676 )
2011
15
Traumatic bone cyst suggestive of a chronic periapical abscess: a case report. ( 21771187 )
2011
16
Outcomes in patients hospitalized for periapical abscess in the United States: an analysis involving the use of a nationwide inpatient sample. ( 20807911 )
2010
17
Outcomes in Patients Hospitalized for Periapical Abscess in the United States. ( 25547691 )
2010
18
Chronic temporal abscess resulting from a periapical abscess of the upper right first molar. ( 19329233 )
2009
19
Maxillary sinusitis and periapical abscess following periodontal therapy: a case report using three-dimensional evaluation. ( 16579714 )
2006
20
Periapical abscess formation and resolution adjacent to dental implants: a clinical report. ( 11208196 )
2001
21
An endodontic periapical abscess mimicking a deep periodontal pocket: a case report. ( 11324272 )
2000
22
Dentin malformation with alveolar bone loss and periapical abscess formation. ( 10197342 )
1999
23
Chronic factitial ulcer of chin cured by endodontic (root-canal) surgery for underlying periapical abscess. ( 10321619 )
1999
24
Aerobic and anaerobic microbiology of periapical abscess. ( 1945488 )
1991
25
Interpret your X-ray. Chronic periapical abscess. ( 3868656 )
1985
26
Effective one-visit therapy for the acute periapical abscess. ( 6596388 )
1984
27
Interpret your x-rays: periapical abscess. ( 6955385 )
1982
28
Intracranial complications of sinusitis in children. A sequela of periapical abscess. ( 7073175 )
1982
29
Metronidazole in the treatment of chronic periapical abscess. ( 6940020 )
1981
30
Bacteriology of acute periapical abscess in children. ( 6943273 )
1981
31
Management and treatment of an immunosuppressed patient with an active periapical abscess. ( 89663 )
1977
32
A case report of an unusual central incisor associated with a chronic periapical abscess. ( 1072804 )
1976
33
Normal pathways of infection resulting from acute periapical abscess of mandibular teeth. ( 1075114 )
1976
34
An unusual periapical abscess. ( 4518041 )
1973
35
Periapical abscess from dens in dente. ( 5280468 )
1971
36
Periapical abscess with intranasal fistula. ( 5288827 )
1971
37
Endodontic management of large periapical abscess. ( 5225994 )
1966
38
Occult periapical abscess: a case report. ( 13842722 )
1960
39
Periapical abscess. ( 13640868 )
1959
40
Isolation of a Bacillus anthracis-like organism from a periapical abscess. ( 18110516 )
1949
41
The periapical abscess. ( 18139253 )
1949

Variations for Suppurative Periapical Periodontitis

Expression for Suppurative Periapical Periodontitis

Search GEO for disease gene expression data for Suppurative Periapical Periodontitis.

Pathways for Suppurative Periapical Periodontitis

Pathways related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.62 CTSG MMP19

GO Terms for Suppurative Periapical Periodontitis

Cellular components related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.62 CTSG LTF

Biological processes related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.5 CTSG LTF MMP19
2 cellular response to lipopolysaccharide GO:0071222 9.37 CTSG GFI1
3 defense response to Gram-negative bacterium GO:0050829 9.26 CTSG LTF
4 extracellular matrix disassembly GO:0022617 9.16 CTSG MMP19
5 antimicrobial humoral response GO:0019730 8.96 CTSG LTF
6 antibacterial humoral response GO:0019731 8.62 CTSG LTF

Molecular functions related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.46 CHD7 CTSG LTF MMP19
2 heparin binding GO:0008201 9.32 CTSG LTF
3 serine-type peptidase activity GO:0008236 9.26 CTSG LTF
4 peptidase activity GO:0008233 9.13 CTSG LTF MMP19
5 serine-type endopeptidase activity GO:0004252 8.8 CTSG LTF MMP19

Sources for Suppurative Periapical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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