MCID: SPP003
MIFTS: 30

Suppurative Periapical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Suppurative Periapical Periodontitis

MalaCards integrated aliases for Suppurative Periapical Periodontitis:

Name: Suppurative Periapical Periodontitis 12 15 73
Periapical Abscess 12 55 44
Suppurative Apical Periodontitis 12
Dentoalveolar Abscess 12
Apical Abscess 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2562
MeSH 44 D010482
NCIt 50 C34913
ICD10 33 K04.6 K04.7
UMLS 73 C0031024

Summaries for Suppurative Periapical Periodontitis

MalaCards based summary : Suppurative Periapical Periodontitis, also known as periapical abscess, is related to dental abscess and hypochondroplasia. An important gene associated with Suppurative Periapical Periodontitis is PIMREG (PICALM Interacting Mitotic Regulator), and among its related pathways/superpathways are Defensins and Matrix Metalloproteinases. The drugs Amoxicillin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotype is neoplasm.

Related Diseases for Suppurative Periapical Periodontitis

Diseases related to Suppurative Periapical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 dental abscess 11.2
2 hypochondroplasia 9.9
3 hypophosphatemic rickets, x-linked recessive 9.9
4 rickets 9.9
5 acute apical periodontitis 9.7
6 periodontitis 9.7
7 gingivitis 9.5 CTSG LTF
8 cholangitis, primary sclerosing 9.2 CTSG LTF

Graphical network of the top 20 diseases related to Suppurative Periapical Periodontitis:



Diseases related to Suppurative Periapical Periodontitis

Symptoms & Phenotypes for Suppurative Periapical Periodontitis

MGI Mouse Phenotypes related to Suppurative Periapical Periodontitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 CTSG LTF MMP19

Drugs & Therapeutics for Suppurative Periapical Periodontitis

Drugs for Suppurative Periapical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3 Amoxicillin-Potassium Clavulanate Combination Phase 4
4 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
5 Anti-Infective Agents Phase 4,Phase 2,Phase 3
6 beta-Lactamase Inhibitors Phase 4
7 Clavulanic Acid Phase 4
8 Clindamycin palmitate Phase 4
9 Clindamycin phosphate Phase 4
10
Chlorhexidine Approved, Vet_approved Phase 2, Phase 3 55-56-1 9552079 2713
11 Anti-Inflammatory Agents Phase 2, Phase 3,Not Applicable
12 Anti-Infective Agents, Local Phase 2, Phase 3
13 Chlorhexidine gluconate Phase 2, Phase 3
14 Dermatologic Agents Phase 2, Phase 3
15 Disinfectants Phase 2, Phase 3
16 Pharmaceutical Solutions Phase 2, Phase 3
17 Root Canal Irrigants Phase 2, Phase 3
18 Neem Nutraceutical Phase 2, Phase 3
19
Acetaminophen Approved Not Applicable 103-90-2 1983
20
Codeine Approved, Illicit Not Applicable 76-57-3 5284371
21
Guaifenesin Approved, Investigational, Vet_approved Not Applicable 93-14-1 3516
22
Tramadol Approved, Investigational Not Applicable 27203-92-5 33741
23
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
24 Analgesics Not Applicable
25 Analgesics, Non-Narcotic Not Applicable
26 Analgesics, Opioid Not Applicable
27 Antipyretics Not Applicable
28 Antitussive Agents Not Applicable
29 Central Nervous System Depressants Not Applicable
30 Chlorpheniramine, phenylpropanolamine drug combination Not Applicable
31 Narcotics Not Applicable
32 Peripheral Nervous System Agents Not Applicable
33 Respiratory System Agents Not Applicable
34 Antiemetics Not Applicable
35 Antineoplastic Agents, Hormonal Not Applicable
36 Autonomic Agents Not Applicable
37 BB 1101 Not Applicable
38 Dexamethasone acetate Not Applicable 1177-87-3
39 Gastrointestinal Agents Not Applicable
40 glucocorticoids Not Applicable
41 HIV Protease Inhibitors Not Applicable
42 Hormone Antagonists Not Applicable
43 Hormones Not Applicable
44 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
45
protease inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old. Completed NCT03533231 Phase 4
2 AUGMENTIN™ in Dental Infections Completed NCT02141217 Phase 4 Amoxicillin/clavulanate;Clindamycin
3 Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy Not yet recruiting NCT02943759 Phase 2, Phase 3 Neem leaf extract;Chlorhexidine gluconate
4 Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess Completed NCT02750696 Not Applicable Fixed-dose oral tablet of codeine/ acetaminophen every 4 hours for 3 days;Fixed-dose oral tablet of tramadol/ acetaminophen every 4 hours for 3 days
5 Periodontal and Periapical Inflammation and Pregnancy Completed NCT00490165
6 The Effects of Dexamethasone on the Time to Pain Resolution in Dental Periapical Abscess Recruiting NCT03005522 Not Applicable oral dexamethasone;Placebo Oral Capsule
7 Clinical Applicability of PBSCIMMO as a Single Material in Endodontic Obturations Enrolling by invitation NCT03514264 Not Applicable

Search NIH Clinical Center for Suppurative Periapical Periodontitis

Cochrane evidence based reviews: periapical abscess

Genetic Tests for Suppurative Periapical Periodontitis

Anatomical Context for Suppurative Periapical Periodontitis

MalaCards organs/tissues related to Suppurative Periapical Periodontitis:

41
Bone

Publications for Suppurative Periapical Periodontitis

Articles related to Suppurative Periapical Periodontitis:

# Title Authors Year
1
Chondroblastic osteosarcoma mimicking periapical abscess. ( 28877285 )
2017
2
A retrospective cohort study on the association between periapical abscess, advanced periodontal disease, and the national oral health screening program among Korean adults. ( 22186394 )
2013
3
Dentin malformation with alveolar bone loss and periapical abscess formation. ( 10197342 )
1999

Variations for Suppurative Periapical Periodontitis

Expression for Suppurative Periapical Periodontitis

Search GEO for disease gene expression data for Suppurative Periapical Periodontitis.

Pathways for Suppurative Periapical Periodontitis

Pathways related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.31 CTSG LTF
2
Show member pathways
10.62 CTSG MMP19

GO Terms for Suppurative Periapical Periodontitis

Cellular components related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.96 CTSG MMP19
2 secretory granule GO:0030141 8.62 CTSG LTF

Biological processes related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.5 CTSG LTF MMP19
2 defense response to bacterium GO:0042742 9.4 CTSG LTF
3 cellular protein metabolic process GO:0044267 9.37 CTSG LTF
4 defense response to Gram-negative bacterium GO:0050829 9.26 CTSG LTF
5 extracellular matrix disassembly GO:0022617 9.16 CTSG MMP19
6 antimicrobial humoral response GO:0019730 8.96 CTSG LTF
7 antibacterial humoral response GO:0019731 8.62 CTSG LTF

Molecular functions related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.26 CTSG LTF
2 serine-type peptidase activity GO:0008236 9.16 CTSG LTF
3 peptidase activity GO:0008233 9.13 CTSG LTF MMP19
4 serine-type endopeptidase activity GO:0004252 8.8 CTSG LTF MMP19

Sources for Suppurative Periapical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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