MCID: SPR021
MIFTS: 31

Supraglottis Cancer

Categories: Cancer diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Supraglottis Cancer

MalaCards integrated aliases for Supraglottis Cancer:

Name: Supraglottis Cancer 12 15
Malignant Tumor of Supraglottis 12 70
Malignant Neoplasm of Extrinsic Larynx 12
Malignant Neoplasm of Supraglottis 12
Malignant Supraglottic Tumor 12
Ca Larynx - Supraglottis 12
Neoplasm of Supraglottis 70
Supraglottis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13476
ICD9CM 34 161.1
NCIt 50 C3545
SNOMED-CT 67 187842004
ICD10 32 C32.1
UMLS 70 C0153484 C0345726

Summaries for Supraglottis Cancer

MalaCards based summary : Supraglottis Cancer, also known as malignant tumor of supraglottis, is related to supraglottis neoplasm and squamous cell papilloma. An important gene associated with Supraglottis Cancer is PDPN (Podoplanin), and among its related pathways/superpathways are MicroRNAs in cancer and Glioblastoma Multiforme. The drugs Ethanol and Acetaminophen have been mentioned in the context of this disorder. Related phenotypes are digestive/alimentary and respiratory system

Related Diseases for Supraglottis Cancer

Diseases related to Supraglottis Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 supraglottis neoplasm 32.3 PDPN CDKN2A
2 squamous cell papilloma 30.0 TP53 CDKN2A
3 soft tissue sarcoma 29.6 TP53 EGFR
4 lymphangioma 29.4 TP53 PDPN EGFR
5 small cell carcinoma 29.4 TP53 EGFR CDKN2A
6 carcinosarcoma 29.4 TP53 EGFR CDKN2A
7 papilloma 29.4 TP53 KRT13 EGFR CDKN2A
8 salivary gland carcinoma 29.3 TP53 EGFR CDKN2A
9 squamous cell carcinoma 29.2 TP53 PDPN EGFR CDKN2A
10 adenoid cystic carcinoma 29.2 TP53 PDPN EGFR CDKN2A
11 larynx cancer 29.2 TP53 EGFR CDKN2A
12 inverted papilloma 29.1 TP53 KRT13 EGFR CDKN2A
13 supraglottis verrucous carcinoma 11.2
14 supraglottis squamous cell carcinoma 11.1
15 gallbladder adenoma 10.3 PDPN CDKN2A
16 atypical neurofibroma 10.3 PDPN CDKN2A
17 vulvar intraepithelial neoplasia 10.2 TP53 CDKN2A
18 xanthogranulomatous cholecystitis 10.2 TP53 PDPN
19 conjunctival squamous cell carcinoma 10.2 TP53 PDPN
20 ovarian seromucinous carcinoma 10.2 TP53 CDKN2A
21 spitz nevus 10.2 TP53 CDKN2A
22 bizarre leiomyoma 10.2 TP53 CDKN2A
23 lip cancer 10.2 TP53 PDPN
24 adult malignant schwannoma 10.2 TP53 CDKN2A
25 suppressor of tumorigenicity 3 10.2 TP53 CDKN2A
26 localized osteosarcoma 10.2 TP53 CDKN2A
27 anal canal carcinoma 10.2 KRT13 CDKN2A
28 malignant exocrine pancreas neoplasm 10.2 TP53 CDKN2A
29 chronic cervicitis 10.2 TP53 CDKN2A
30 thyroid lymphoma 10.2 TP53 CDKN2A
31 keratocystic odontogenic tumor 10.2 TP53 PDPN
32 bladder clear cell adenocarcinoma 10.2 TP53 CDKN2A
33 glandular cystitis 10.2 TP53 KRT13
34 male reproductive organ benign neoplasm 10.2 TP53 CDKN2A
35 malignant spiradenoma 10.2 TP53 CDKN2A
36 bile duct adenoma 10.1 TP53 CDKN2A
37 vaginal cancer 10.1 TP53 CDKN2A
38 nasal cavity adenocarcinoma 10.1 TP53 CDKN2A
39 low-grade astrocytoma 10.1 TP53 CDKN2A
40 gliofibroma 10.1 TP53 CDKN2A
41 nasal cavity cancer 10.1 TP53 CDKN2A
42 prostate squamous cell carcinoma 10.1 TP53 CDKN2A
43 borst-jadassohn intraepidermal carcinoma 10.1 TP53 CDKN2A
44 familial retinoblastoma 10.1 TP53 CDKN2A
45 neurofibrosarcoma 10.1 TP53 CDKN2A
46 acanthoma 10.1 TP53 CDKN2A
47 megaesophagus 10.1 TP53 CDKN2A
48 anal squamous cell carcinoma 10.1 TP53 CDKN2A
49 penile benign neoplasm 10.1 TP53 PDPN CDKN2A
50 nodular malignant melanoma 10.1 TP53 CDKN2A

Comorbidity relations with Supraglottis Cancer via Phenotypic Disease Network (PDN):


Larynx Cancer Protein-Energy Malnutrition
Swallowing Disorders

Graphical network of the top 20 diseases related to Supraglottis Cancer:



Diseases related to Supraglottis Cancer

Symptoms & Phenotypes for Supraglottis Cancer

MGI Mouse Phenotypes related to Supraglottis Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 CDKN2A EGFR KRT13 MMP15 MMP16 PDPN
2 respiratory system MP:0005388 9.1 CDKN2A EGFR MMP15 PDPN PRIMA1 TP53

Drugs & Therapeutics for Supraglottis Cancer

Drugs for Supraglottis Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved 64-17-5 702
2
Acetaminophen Approved 103-90-2 1983
3
Codeine Approved, Illicit 76-57-3 5284371
4
Ibuprofen Approved 15687-27-1 3672
5 Anesthetics, General
6 Anesthetics
7 Narcotics
8 Antibiotics, Antitubercular
9 Analgesics
10 Anti-Bacterial Agents
11 Proton Pump Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Sleep Endoscopy to Predict Outcomes of Pediatric Adenotonsillectomy Enrolling by invitation NCT02693977
2 Treatment of Children With Obstructive Sleep Apnea and Laryngomalacia: the Role of Laser Supraglottoplasty Terminated NCT00394550

Search NIH Clinical Center for Supraglottis Cancer

Genetic Tests for Supraglottis Cancer

Anatomical Context for Supraglottis Cancer

Publications for Supraglottis Cancer

Articles related to Supraglottis Cancer:

# Title Authors PMID Year
1
Lymph Nodes Dissection in Elderly Patients with T3-T4 Laryngeal Cancer. 61
33324044 2020
2
Larynx cancer in Slovakia and the role of anatomical subsites. 61
10705091 1999

Variations for Supraglottis Cancer

Expression for Supraglottis Cancer

Search GEO for disease gene expression data for Supraglottis Cancer.

Pathways for Supraglottis Cancer

GO Terms for Supraglottis Cancer

Biological processes related to Supraglottis Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replicative senescence GO:0090399 8.96 TP53 CDKN2A
2 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.62 TP53 EGFR

Molecular functions related to Supraglottis Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloaminopeptidase activity GO:0070006 9.16 MMP16 MMP15
2 chaperone binding GO:0051087 9.13 TP53 PDPN DNAJB7
3 MDM2/MDM4 family protein binding GO:0097371 8.62 TP53 CDKN2A

Sources for Supraglottis Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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