MCID: SPR022
MIFTS: 31

Supraglottis Neoplasm

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Supraglottis Neoplasm

MalaCards integrated aliases for Supraglottis Neoplasm:

Name: Supraglottis Neoplasm 12 15
Neoplasm of Supraglottis 12
Supraglottic Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8002
NCIt 51 C6793
UMLS 74 C0345726

Summaries for Supraglottis Neoplasm

MalaCards based summary : Supraglottis Neoplasm, also known as neoplasm of supraglottis, is related to supraglottis cancer and olfactory groove meningioma. An important gene associated with Supraglottis Neoplasm is ARHGEF6 (Rac/Cdc42 Guanine Nucleotide Exchange Factor 6), and among its related pathways/superpathways are Endometrial cancer and DNA Damage Response. Affiliated tissues include cervix, skin and tongue, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Supraglottis Neoplasm

Diseases related to Supraglottis Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 supraglottis cancer 31.8 ARHGEF6 ENO2 PGRMC1 TP53
2 olfactory groove meningioma 10.3 PGRMC1 TP53
3 atypical follicular adenoma 10.3 ENO2 TP53
4 anterior cranial fossa meningioma 10.3 PGRMC1 TP53
5 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 TP53
6 cerebellum cancer 10.3 ENO2 TP53
7 cerebral neuroblastoma 10.3 ENO2 TP53
8 malignant teratoma 10.3 ENO2 TP53
9 cerebral ventricle cancer 10.3 ENO2 TP53
10 rhabdoid cancer 10.3 ENO2 TP53
11 glomus tumor 10.2 ENO2 TP53
12 cystic teratoma 10.2 ENO2 TP53
13 central nervous system benign neoplasm 10.2 ENO2 TP53
14 cerebellar liponeurocytoma 10.2 ENO2 TP53
15 cerebral primitive neuroectodermal tumor 10.2 ENO2 TP53
16 mixed cell type cancer 10.2 ENO2 TP53
17 liver angiosarcoma 10.2 ENO2 TP53
18 granulosa cell tumor of the ovary 10.2 ENO2 TP53
19 bladder squamous cell carcinoma 10.2 CDKN2A TP53
20 keratinizing squamous cell carcinoma 10.2 CDKN2A TP53
21 spitz nevus 10.2 CDKN2A TP53
22 medullomyoblastoma 10.2 ENO2 TP53
23 bladder carcinoma in situ 10.2 CDKN2A TP53
24 vulva squamous cell carcinoma 10.2 CDKN2A TP53
25 scrotal carcinoma 10.2 CDKN2A TP53
26 thyroid lymphoma 10.2 CDKN2A TP53
27 nasal cavity adenocarcinoma 10.2 CDKN2A TP53
28 causalgia 10.2 ENO2 SCN10A
29 bartholin's gland disease 10.2 CDKN2A TP53
30 anal squamous cell carcinoma 10.2 CDKN2A TP53
31 adult medulloblastoma 10.2 ENO2 TP53
32 megaesophagus 10.2 CDKN2A TP53
33 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A TP53
34 gastric adenosquamous carcinoma 10.2 CDKN2A TP53
35 anogenital venereal wart 10.2 CDKN2A TP53
36 cervix uteri carcinoma in situ 10.2 CDKN2A TP53
37 uterus carcinoma in situ 10.2 CDKN2A TP53
38 germ cell and embryonal cancer 10.2 ENO2 TP53
39 tracheal cancer 10.2 ENO2 PGRMC1
40 meningeal melanocytoma 10.2 CDKN2A ENO2
41 suppressor of tumorigenicity 3 10.2 CDKN2A TP53
42 dedifferentiated liposarcoma 10.2 CDKN2A TP53
43 endocervical adenocarcinoma 10.2 CDKN2A TP53
44 necrotizing sialometaplasia 10.1 CDKN2A TP53
45 tongue disease 10.1 CDKN2A TP53
46 non-proliferative fibrocystic change of the breast 10.1 CCND1 TP53
47 synchronous bilateral breast carcinoma 10.1 CCND1 TP53
48 cll/sll 10.1 CCND1 TP53
49 tonsil cancer 10.1 CDKN2A TP53
50 squamous cell papilloma 10.1 CDKN2A TP53

Graphical network of the top 20 diseases related to Supraglottis Neoplasm:



Diseases related to Supraglottis Neoplasm

Symptoms & Phenotypes for Supraglottis Neoplasm

GenomeRNAi Phenotypes related to Supraglottis Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 ARHGEF6 CDKN2A MAEA PGRMC1 TP53
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 ARHGEF6 CDKN2A MAEA PGRMC1 TP53 CCND1

MGI Mouse Phenotypes related to Supraglottis Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 APP ARHGEF6 CCND1 CDKN2A ENO2 MAEA
2 hematopoietic system MP:0005397 9.87 APP ARHGEF6 CCND1 CDKN2A MAEA PDPN
3 immune system MP:0005387 9.8 APP ARHGEF6 CCND1 CDKN2A MAEA PDPN
4 integument MP:0010771 9.7 APP CCND1 CDKN2A MAEA PDPN SCN10A
5 nervous system MP:0003631 9.56 APP ARHGEF6 CCND1 CDKN2A ENO2 PGRMC1
6 respiratory system MP:0005388 9.1 CCND1 CDKN2A ENO2 PDPN SCN10A TP53

Drugs & Therapeutics for Supraglottis Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter, Randomized, Case-control Study of Unilateral vs Bilateral Neck Dissection for cN0 Supraglottic Laryngeal Cancer Recruiting NCT03392220 Not Applicable

Search NIH Clinical Center for Supraglottis Neoplasm

Genetic Tests for Supraglottis Neoplasm

Anatomical Context for Supraglottis Neoplasm

MalaCards organs/tissues related to Supraglottis Neoplasm:

42
Cervix, Skin, Tongue, B Cells, Tonsil, Bone, Cerebellum

Publications for Supraglottis Neoplasm

Variations for Supraglottis Neoplasm

Expression for Supraglottis Neoplasm

Search GEO for disease gene expression data for Supraglottis Neoplasm.

Pathways for Supraglottis Neoplasm

Pathways related to Supraglottis Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 ARHGEF6 CCND1 CDKN2A TP53
2
Show member pathways
12.1 CCND1 CDKN2A TP53
3 12.08 CCND1 CDKN2A TP53
4 12.08 CCND1 CDKN2A TP53
5
Show member pathways
12.06 CCND1 CDKN2A TP53
6 11.97 CCND1 CDKN2A TP53
7 11.78 CCND1 CDKN2A TP53
8 11.67 APP CCND1 TP53
9 11.56 CCND1 CDKN2A TP53
10 11.48 CCND1 CDKN2A TP53
11 11.2 CCND1 CDKN2A TP53
12 11.03 CCND1 TP53
13 11.02 CDKN2A TP53
14 10.86 APP CCND1 TP53
15 10.8 CDKN2A TP53
16
Show member pathways
10.78 CDKN2A TP53
17 10.51 CCND1 CDKN2A TP53

GO Terms for Supraglottis Neoplasm

Biological processes related to Supraglottis Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.71 APP ARHGEF6 CDKN2A TP53
2 cell cycle GO:0007049 9.67 CCND1 CDKN2A MAEA TP53
3 negative regulation of cell proliferation GO:0008285 9.56 APP CDKN2A PDPN TP53
4 positive regulation of G2/M transition of mitotic cell cycle GO:0010971 9.32 APP CCND1
5 replicative senescence GO:0090399 9.16 CDKN2A TP53
6 amyloid fibril formation GO:1990000 8.96 APP CDKN2A
7 mitotic G1 DNA damage checkpoint GO:0031571 8.62 CCND1 TP53

Molecular functions related to Supraglottis Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Supraglottis Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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