Supraglottis Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Supraglottis Neoplasm

MalaCards integrated aliases for Supraglottis Neoplasm:

Name: Supraglottis Neoplasm ¹² ¹⁵

Neoplasm of Supraglottis ¹²

Supraglottic Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8002

NCIt ⁵¹ C6793

UMLS ⁷⁴ C0345726

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Summaries for Supraglottis Neoplasm

MalaCards based summary : Supraglottis Neoplasm, also known as neoplasm of supraglottis, is related to supraglottis cancer and olfactory groove meningioma. An important gene associated with Supraglottis Neoplasm is ARHGEF6 (Rac/Cdc42 Guanine Nucleotide Exchange Factor 6), and among its related pathways/superpathways are Endometrial cancer and DNA Damage Response. Affiliated tissues include cervix, skin and tongue, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Supraglottis Neoplasm

Diseases related to Supraglottis Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)

#	Related Disease	Score	Top Affiliating Genes
1	supraglottis cancer	31.8	ARHGEF6 ENO2 PGRMC1 TP53
2	olfactory groove meningioma	10.3	PGRMC1 TP53
3	atypical follicular adenoma	10.3	ENO2 TP53
4	anterior cranial fossa meningioma	10.3	PGRMC1 TP53
5	central nervous system primitive neuroectodermal neoplasm	10.3	ENO2 TP53
6	cerebellum cancer	10.3	ENO2 TP53
7	cerebral neuroblastoma	10.3	ENO2 TP53
8	malignant teratoma	10.3	ENO2 TP53
9	cerebral ventricle cancer	10.3	ENO2 TP53
10	rhabdoid cancer	10.3	ENO2 TP53
11	glomus tumor	10.2	ENO2 TP53
12	cystic teratoma	10.2	ENO2 TP53
13	central nervous system benign neoplasm	10.2	ENO2 TP53
14	cerebellar liponeurocytoma	10.2	ENO2 TP53
15	cerebral primitive neuroectodermal tumor	10.2	ENO2 TP53
16	mixed cell type cancer	10.2	ENO2 TP53
17	liver angiosarcoma	10.2	ENO2 TP53
18	granulosa cell tumor of the ovary	10.2	ENO2 TP53
19	bladder squamous cell carcinoma	10.2	CDKN2A TP53
20	keratinizing squamous cell carcinoma	10.2	CDKN2A TP53
21	spitz nevus	10.2	CDKN2A TP53
22	medullomyoblastoma	10.2	ENO2 TP53
23	bladder carcinoma in situ	10.2	CDKN2A TP53
24	vulva squamous cell carcinoma	10.2	CDKN2A TP53
25	scrotal carcinoma	10.2	CDKN2A TP53
26	thyroid lymphoma	10.2	CDKN2A TP53
27	nasal cavity adenocarcinoma	10.2	CDKN2A TP53
28	causalgia	10.2	ENO2 SCN10A
29	bartholin's gland disease	10.2	CDKN2A TP53
30	anal squamous cell carcinoma	10.2	CDKN2A TP53
31	adult medulloblastoma	10.2	ENO2 TP53
32	megaesophagus	10.2	CDKN2A TP53
33	glycogen-rich clear cell breast carcinoma	10.2	CDKN2A TP53
34	gastric adenosquamous carcinoma	10.2	CDKN2A TP53
35	anogenital venereal wart	10.2	CDKN2A TP53
36	cervix uteri carcinoma in situ	10.2	CDKN2A TP53
37	uterus carcinoma in situ	10.2	CDKN2A TP53
38	germ cell and embryonal cancer	10.2	ENO2 TP53
39	tracheal cancer	10.2	ENO2 PGRMC1
40	meningeal melanocytoma	10.2	CDKN2A ENO2
41	suppressor of tumorigenicity 3	10.2	CDKN2A TP53
42	dedifferentiated liposarcoma	10.2	CDKN2A TP53
43	endocervical adenocarcinoma	10.2	CDKN2A TP53
44	necrotizing sialometaplasia	10.1	CDKN2A TP53
45	tongue disease	10.1	CDKN2A TP53
46	non-proliferative fibrocystic change of the breast	10.1	CCND1 TP53
47	synchronous bilateral breast carcinoma	10.1	CCND1 TP53
48	cll/sll	10.1	CCND1 TP53
49	tonsil cancer	10.1	CDKN2A TP53
50	squamous cell papilloma	10.1	CDKN2A TP53

Graphical network of the top 20 diseases related to Supraglottis Neoplasm:

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Symptoms & Phenotypes for Supraglottis Neoplasm

GenomeRNAi Phenotypes related to Supraglottis Neoplasm according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.64	ARHGEF6 CDKN2A MAEA PGRMC1 TP53
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.64	ARHGEF6 CDKN2A MAEA PGRMC1 TP53 CCND1

MGI Mouse Phenotypes related to Supraglottis Neoplasm:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.07	APP ARHGEF6 CCND1 CDKN2A ENO2 MAEA
2	hematopoietic system	MP:0005397	9.87	APP ARHGEF6 CCND1 CDKN2A MAEA PDPN
3	immune system	MP:0005387	9.8	APP ARHGEF6 CCND1 CDKN2A MAEA PDPN
4	integument	MP:0010771	9.7	APP CCND1 CDKN2A MAEA PDPN SCN10A
5	nervous system	MP:0003631	9.56	APP ARHGEF6 CCND1 CDKN2A ENO2 PGRMC1
6	respiratory system	MP:0005388	9.1	CCND1 CDKN2A ENO2 PDPN SCN10A TP53

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Drugs & Therapeutics for Supraglottis Neoplasm

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Multicenter, Randomized, Case-control Study of Unilateral vs Bilateral Neck Dissection for cN0 Supraglottic Laryngeal Cancer	Recruiting	NCT03392220	Not Applicable

Search NIH Clinical Center for Supraglottis Neoplasm

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Genetic Tests for Supraglottis Neoplasm

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Anatomical Context for Supraglottis Neoplasm

MalaCards organs/tissues related to Supraglottis Neoplasm:

⁴²

Cervix, Skin, Tongue, B Cells, Tonsil, Bone, Cerebellum

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Publications for Supraglottis Neoplasm

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Genes for Supraglottis Neoplasm

Genes related to Supraglottis Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	16.5	DISEASES inferred ¹⁵
2	PGRMC1	Progesterone Receptor Membrane Component 1	Protein Coding	14.81	DISEASES inferred ¹⁵
3	SCN10A	Sodium Voltage-Gated Channel Alpha Subunit 10	Protein Coding	14.54	DISEASES inferred ¹⁵
4	ENO2	Enolase 2	Protein Coding	13.6	DISEASES inferred ¹⁵
5	TP53	Tumor Protein P53	Protein Coding	13.29	DISEASES inferred ¹⁵
6	APP	Amyloid Beta Precursor Protein	Protein Coding	13.21	DISEASES inferred ¹⁵
7	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	13.11	DISEASES inferred ¹⁵
8	CCND1	Cyclin D1	Protein Coding	13.02	DISEASES inferred ¹⁵
9	PDPN	Podoplanin	Protein Coding	5.04	DISEASES inferred ¹⁵
10	MAEA	Macrophage Erythroblast Attacher	Protein Coding	4.74	DISEASES inferred ¹⁵

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Variations for Supraglottis Neoplasm

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Expression for Supraglottis Neoplasm

Search GEO for disease gene expression data for Supraglottis Neoplasm.

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Pathways for Supraglottis Neoplasm

Pathways related to Supraglottis Neoplasm according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁸ Show member pathways Acute myeloid leukemia ³⁸ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁷ Chronic myeloid leukemia ³⁸ Colorectal cancer ³⁸ Pancreatic cancer ³⁸ Prostate cancer ³⁸ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁸	12.52	ARHGEF6 CCND1 CDKN2A TP53
2	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁸	12.1	CCND1 CDKN2A TP53
3	Human T-cell leukemia virus 1 infection ³⁸	12.08	CCND1 CDKN2A TP53
4	Cell cycle ³⁸ ¹	12.08	CCND1 CDKN2A TP53
5	Cyclins and Cell Cycle Regulation ⁶⁵ Show member pathways Cell Cycle Control by BTG Proteins ⁶⁵ Cyclin D associated events in G1 ⁶⁷ G1 Phase ⁶⁷ G1-S Phase Transition ⁶⁵ Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes ⁶⁷	12.06	CCND1 CDKN2A TP53
6	Viral carcinogenesis ³⁸	11.97	CCND1 CDKN2A TP53
7	Cellular senescence (KEGG) ³⁸	11.78	CCND1 CDKN2A TP53
8	TGF-beta Signaling Pathway (WikiPathways) ¹	11.67	APP CCND1 TP53
9	DNA Damage Response (only ATM dependent) ¹	11.56	CCND1 CDKN2A TP53
10	Glioblastoma Multiforme ⁶⁵	11.48	CCND1 CDKN2A TP53
11	Bladder cancer ¹ ³⁸	11.2	CCND1 CDKN2A TP53
12	GADD45 Pathway ⁶⁵	11.03	CCND1 TP53
13	Oncogene Induced Senescence ⁶⁷	11.02	CDKN2A TP53
14	Copper homeostasis ¹	10.86	APP CCND1 TP53
15	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶⁵	10.8	CDKN2A TP53
16	TP53 Network ¹ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁷	10.78	CDKN2A TP53
17	Photodynamic therapy-induced AP-1 survival signaling. ¹	10.51	CCND1 CDKN2A TP53

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GO Terms for Supraglottis Neoplasm

Biological processes related to Supraglottis Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	apoptotic process	GO:0006915	9.71	APP ARHGEF6 CDKN2A TP53
2	cell cycle	GO:0007049	9.67	CCND1 CDKN2A MAEA TP53
3	negative regulation of cell proliferation	GO:0008285	9.56	APP CDKN2A PDPN TP53
4	positive regulation of G2/M transition of mitotic cell cycle	GO:0010971	9.32	APP CCND1
5	replicative senescence	GO:0090399	9.16	CDKN2A TP53
6	amyloid fibril formation	GO:1990000	8.96	APP CDKN2A
7	mitotic G1 DNA damage checkpoint	GO:0031571	8.62	CCND1 TP53

Molecular functions related to Supraglottis Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	disordered domain specific binding	GO:0097718	8.62	CDKN2A TP53

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