MCID: SPR023
MIFTS: 21

Supraglottis Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Supraglottis Squamous Cell Carcinoma

MalaCards integrated aliases for Supraglottis Squamous Cell Carcinoma:

Name: Supraglottis Squamous Cell Carcinoma 12
Epidermoid Carcinoma of the Supraglottis 12
Supraglottic Squamous Cell Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7587
NCIt 50 C4945
UMLS 73 C0749163

Summaries for Supraglottis Squamous Cell Carcinoma

MalaCards based summary : Supraglottis Squamous Cell Carcinoma, also known as epidermoid carcinoma of the supraglottis, is related to vascular disease. An important gene associated with Supraglottis Squamous Cell Carcinoma is NOS2 (Nitric Oxide Synthase 2), and among its related pathways/superpathways are Pathways in cancer and Immune response IL-23 signaling pathway. Affiliated tissues include skin and endothelial, and related phenotype is neoplasm.

Related Diseases for Supraglottis Squamous Cell Carcinoma

Diseases related to Supraglottis Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vascular disease 9.7 FGF2 NOS2

Symptoms & Phenotypes for Supraglottis Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Supraglottis Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.62 FGF2 NOS2

Drugs & Therapeutics for Supraglottis Squamous Cell Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Local Control After Robot-assisted Supraglottic Laryngectomy Completed NCT03357107
2 Efficacy and Safety of TORS for SCCA Recruiting NCT01819480 Not Applicable
3 Radiotherapy vs Neck Dissection for Clinical T1/2N0 Supraglottic Cancer Not yet recruiting NCT03358602 Not Applicable

Search NIH Clinical Center for Supraglottis Squamous Cell Carcinoma

Genetic Tests for Supraglottis Squamous Cell Carcinoma

Anatomical Context for Supraglottis Squamous Cell Carcinoma

MalaCards organs/tissues related to Supraglottis Squamous Cell Carcinoma:

41
Skin, Endothelial

Publications for Supraglottis Squamous Cell Carcinoma

Articles related to Supraglottis Squamous Cell Carcinoma:

# Title Authors Year
1
Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases. ( 30536822 )
2018
2
CO2 Transoral Microsurgery for Supraglottic Squamous Cell Carcinoma. ( 30234007 )
2018
3
Intravenous Opioid Drug Abuse as an Independent Risk Factor for Supraglottic Squamous Cell Carcinoma - A Case Control Study. ( 28950046 )
2017
4
Survival Differences between Organ Preservation Surgery and Definitive Radiotherapy in Early Supraglottic Squamous Cell Carcinoma. ( 24255085 )
2013
5
Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma. ( 23151319 )
2012
6
Prognostic significance of vascular endothelial growth factor-C expression and lymphatic vessel density in supraglottic squamous cell carcinoma. ( 19444880 )
2009
7
c-myc and bcl-2 Expression in supraglottic squamous cell carcinoma of the larynx. ( 15243561 )
2004
8
[Inducible nitric oxide synthase and basic fibroblast growth factor expression as prognostic factors in supraglottic squamous cell carcinoma]. ( 12969533 )
2003
9
[Expression of inducible nitric oxide synthase and basic fibroblast growth factor in supraglottic squamous cell carcinoma and their clinical significance]. ( 12508542 )
2002

Variations for Supraglottis Squamous Cell Carcinoma

Cosmic variations for Supraglottis Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM44067 TP53 upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.721T>A p.S241T 17:7674242-7674242 10
2 COSM45544 TP53 upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.947C>T p.P316L 17:7673581-7673581 10
3 COSM43597 TP53 upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.538G>T p.E180* 17:7675074-7675074 10
4 COSM10648 TP53 upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 10
5 COSM6913 TP53 upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.783-1G>T p.? 17:7673838-7673838 10
6 COSM521 KRAS upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.35G>A p.G12D 12:25245350-25245350 10

Expression for Supraglottis Squamous Cell Carcinoma

Search GEO for disease gene expression data for Supraglottis Squamous Cell Carcinoma.

Pathways for Supraglottis Squamous Cell Carcinoma

GO Terms for Supraglottis Squamous Cell Carcinoma

Biological processes related to Supraglottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 8.62 FGF2 NOS2

Sources for Supraglottis Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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