MCID: SPR023
MIFTS: 20

Supraglottis Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Supraglottis Squamous Cell Carcinoma

MalaCards integrated aliases for Supraglottis Squamous Cell Carcinoma:

Name: Supraglottis Squamous Cell Carcinoma 12
Epidermoid Carcinoma of the Supraglottis 12
Supraglottic Squamous Cell Carcinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7587
NCIt 51 C4945
UMLS 74 C0749163

Summaries for Supraglottis Squamous Cell Carcinoma

MalaCards based summary : Supraglottis Squamous Cell Carcinoma, also known as epidermoid carcinoma of the supraglottis, is related to vascular disease. An important gene associated with Supraglottis Squamous Cell Carcinoma is NOS2 (Nitric Oxide Synthase 2), and among its related pathways/superpathways are Pathways in cancer and Immune response IL-23 signaling pathway. Affiliated tissues include endothelial, and related phenotype is neoplasm.

Related Diseases for Supraglottis Squamous Cell Carcinoma

Diseases related to Supraglottis Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vascular disease 9.5 FGF2 NOS2

Symptoms & Phenotypes for Supraglottis Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Supraglottis Squamous Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.62 FGF2 NOS2

Drugs & Therapeutics for Supraglottis Squamous Cell Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Local Control After Robot-assisted Supraglottic Laryngectomy Completed NCT03357107
2 Efficacy and Safety of TORS for SCCA Recruiting NCT01819480 Not Applicable
3 Radiotherapy vs Neck Dissection for Clinical T1/2N0 Supraglottic Cancer Not yet recruiting NCT03358602 Not Applicable

Search NIH Clinical Center for Supraglottis Squamous Cell Carcinoma

Genetic Tests for Supraglottis Squamous Cell Carcinoma

Anatomical Context for Supraglottis Squamous Cell Carcinoma

MalaCards organs/tissues related to Supraglottis Squamous Cell Carcinoma:

42
Endothelial

Publications for Supraglottis Squamous Cell Carcinoma

Articles related to Supraglottis Squamous Cell Carcinoma:

# Title Authors Year
1
Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases. ( 30536822 )
2018
2
CO2 Transoral Microsurgery for Supraglottic Squamous Cell Carcinoma. ( 30234007 )
2018
3
Oncologic outcomes with transoral robotic surgery for supraglottic squamous cell carcinoma: Results of the French Robotic Surgery Group of GETTEC. ( 30051531 )
2018
4
Intravenous Opioid Drug Abuse as an Independent Risk Factor for Supraglottic Squamous Cell Carcinoma - A Case Control Study. ( 28950046 )
2017
5
Survival Differences between Organ Preservation Surgery and Definitive Radiotherapy in Early Supraglottic Squamous Cell Carcinoma. ( 24255085 )
2013
6
Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma. ( 23151319 )
2012
7
Prognostic significance of vascular endothelial growth factor-C expression and lymphatic vessel density in supraglottic squamous cell carcinoma. ( 19444880 )
2009
8
c-myc and bcl-2 Expression in supraglottic squamous cell carcinoma of the larynx. ( 15243561 )
2004
9
[Inducible nitric oxide synthase and basic fibroblast growth factor expression as prognostic factors in supraglottic squamous cell carcinoma]. ( 12969533 )
2003
10
[Expression of inducible nitric oxide synthase and basic fibroblast growth factor in supraglottic squamous cell carcinoma and their clinical significance]. ( 12508542 )
2002

Variations for Supraglottis Squamous Cell Carcinoma

Cosmic variations for Supraglottis Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM44067 TP53 upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.721T>A p.S241T 17:7674242-7674242 0
2 COSM45544 TP53 upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.947C>T p.P316L 17:7673581-7673581 0
3 COSM43597 TP53 upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.538G>T p.E180* 17:7675074-7675074 0
4 COSM10648 TP53 upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 0
5 COSM6913 TP53 upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.783-1G>T p.? 17:7673838-7673838 0
6 COSM521 KRAS upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.35G>A p.G12D 12:25245350-25245350 0

Expression for Supraglottis Squamous Cell Carcinoma

Search GEO for disease gene expression data for Supraglottis Squamous Cell Carcinoma.

Pathways for Supraglottis Squamous Cell Carcinoma

GO Terms for Supraglottis Squamous Cell Carcinoma

Biological processes related to Supraglottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 8.62 FGF2 NOS2

Sources for Supraglottis Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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