MCID: SPR023
MIFTS: 22

Supraglottis Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Supraglottis Squamous Cell Carcinoma

MalaCards integrated aliases for Supraglottis Squamous Cell Carcinoma:

Name: Supraglottis Squamous Cell Carcinoma 12
Epidermoid Carcinoma of the Supraglottis 12
Supraglottic Squamous Cell Carcinoma 72

Classifications:



External Ids:

Disease Ontology 12 DOID:7587
NCIt 50 C4945
UMLS 72 C0749163

Summaries for Supraglottis Squamous Cell Carcinoma

MalaCards based summary : Supraglottis Squamous Cell Carcinoma, also known as epidermoid carcinoma of the supraglottis, is related to vascular disease. An important gene associated with Supraglottis Squamous Cell Carcinoma is NOS2 (Nitric Oxide Synthase 2), and among its related pathways/superpathways are Pathways in cancer and Immune response IL-23 signaling pathway. Affiliated tissues include lymph node, bone and skin, and related phenotype is neoplasm.

Related Diseases for Supraglottis Squamous Cell Carcinoma

Diseases related to Supraglottis Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vascular disease 9.2 NOS2 FGF2

Symptoms & Phenotypes for Supraglottis Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Supraglottis Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.62 FGF2 NOS2

Drugs & Therapeutics for Supraglottis Squamous Cell Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Local Control 2 Years After Robot-assisted Supraglottic Laryngectomy: a Multicenter Retrospective Study Completed NCT03357107
2 A Single Arm Study of Efficacy and Functional Quality of Life in Patients Treated With Transoral Robotic Surgery for Oropharyngeal and Supraglottic Squamous Cell Carcinoma Recruiting NCT01819480
3 Radiotherapy Versus Elective Neck Dissection for Management of Cervical Nodes in Clinical T1/2N0 Supraglottic Squamous Cell Carcinoma Not yet recruiting NCT03358602

Search NIH Clinical Center for Supraglottis Squamous Cell Carcinoma

Genetic Tests for Supraglottis Squamous Cell Carcinoma

Anatomical Context for Supraglottis Squamous Cell Carcinoma

MalaCards organs/tissues related to Supraglottis Squamous Cell Carcinoma:

41
Lymph Node, Bone, Skin, Bone Marrow, Endothelial, Pituitary

Publications for Supraglottis Squamous Cell Carcinoma

Articles related to Supraglottis Squamous Cell Carcinoma:

(show top 50) (show all 77)
# Title Authors PMID Year
1
[Inducible nitric oxide synthase and basic fibroblast growth factor expression as prognostic factors in supraglottic squamous cell carcinoma]. 9 38
12969533 2003
2
[Expression of inducible nitric oxide synthase and basic fibroblast growth factor in supraglottic squamous cell carcinoma and their clinical significance]. 9 38
12508542 2002
3
Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases. 38
30536822 2019
4
Hypopharyngeal Skin Cancer Following Total Laryngectomy and Pectoralis Flap Reconstruction: Case Report and Literature Review. 38
30888639 2019
5
Oncologic outcomes with transoral robotic surgery for supraglottic squamous cell carcinoma: Results of the French Robotic Surgery Group of GETTEC. 38
30051531 2018
6
The role of E-cadherin and β-catenin in laryngeal cancer. 38
30046398 2018
7
Intravenous opioid drug abuse as an independent risk factor for supraglottic squamous cell carcinoma-A case-control study. 38
28950046 2018
8
Treatment of early stage Supraglottic squamous cell carcinoma: meta-analysis comparing primary surgery versus primary radiotherapy. 38
29506564 2018
9
CO2 Transoral Microsurgery for Supraglottic Squamous Cell Carcinoma. 38
30234007 2018
10
Rate of Occult Cervical Lymph Node Involvement in Supraglottic Squamous Cell Carcinoma. 38
28589106 2017
11
PD-L1 expressing circulating tumour cells in head and neck cancers. 38
28511705 2017
12
Treatment results of alternating chemoradiotherapy with early assessment for advanced laryngeal cancer: A multi-institutional phase II study. 38
27435048 2017
13
Supraglottic squamous cell carcinomas have distinctive clinical features and prognosis based on subregion. 38
29155864 2017
14
Functional outcomes of supraglottic squamous cell carcinoma treated by transoral laser microsurgery compared with horizontal supraglottic laryngectomy in patients younger and older than 65 years. 38
28177327 2016
15
Transoral laser microsurgery for locally advanced (T3-T4a) supraglottic squamous cell carcinoma: Sixteen years of experience. 38
26872432 2016
16
Clinical outcomes with transoral robotic surgery for supraglottic squamous cell carcinoma: Experience of a French evaluation cooperative subgroup of GETTEC. 38
26435046 2016
17
The role of primary transoral laser microsurgery in laryngeal cancer: a retrospective study. 38
25704647 2015
18
Laryngopyocele: Presenting with pressure symptom. 38
26539381 2015
19
Distant bone metastasis from supraglottic squamous cell carcinoma. 38
25223573 2015
20
Clinical outcomes of transoral robotic surgery for supraglottic squamous cell carcinoma: experience of a french evaluation cooperative subgroup of gettec. 38
26891530 2015
21
Robotic-assisted salvage supraglottic laryngectomy. 38
24964644 2014
22
Survival differences between organ preservation surgery and definitive radiotherapy in early supraglottic squamous cell carcinoma. 38
24255085 2014
23
Late Prevertebral and Spinal Abscess following Chemoradiation for Laryngeal Squamous Cell Carcinoma. 38
24716067 2014
24
Analysis of multicentricity in supraglottic laryngeal carcinoma treated with partial laryngeal surgery. 38
23053372 2013
25
Functional swallowing outcomes following transoral robotic surgery vs primary chemoradiotherapy in patients with advanced-stage oropharynx and supraglottis cancers. 38
23247974 2013
26
Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma. 38
23151319 2012
27
Transoral robotic surgery for supraglottic squamous cell carcinoma. 38
22133967 2012
28
Oncologic outcomes after supracricoid partial laryngectomy. 38
21493316 2011
29
Hypopituitarism caused by pituitary metastasis of supraglottic laryngeal carcinoma: case report. 38
21462828 2010
30
Role of concurrent chemoradiation in laryngeal preservation for supraglottic cancer. 38
20211100 2010
31
Endoscopic partial supraglottic laryngectomies: techniques and results. 38
19716017 2009
32
Endoscopic horizontal partial laryngectomy by CO(2) laser in the management of supraglottic squamous cell carcinoma. 38
19360749 2009
33
Prognostic significance of vascular endothelial growth factor-C expression and lymphatic vessel density in supraglottic squamous cell carcinoma. 38
19444880 2009
34
Expression profiling of supraglottic carcinoma: PTEN and thrombospondin 2 are associated with inhibition of lymphatic metastasis. 38
18720079 2009
35
Efficacy of diagnostic upper node evaluation during (salvage) laryngectomy for supraglottic carcinoma. 38
19031402 2009
36
Supraglottic carcinoma treatment results analysed by therapeutic approach. 38
19460215 2009
37
Overexpression of Cap43 gene in supraglottic laryngeal squamous cell carcinoma. 38
19460198 2009
38
Mixed laryngocele: a case report and review of the literature. 38
18198756 2007
39
Supracricoid laryngectomies: long-term oncological and functional results. 38
16720450 2006
40
Efficacy of routine bilateral neck dissection in the management of the N0 neck in T1-T2 unilateral supraglottic cancer. 38
16419080 2006
41
Supracricoid partial laryngectomy in the treatment of laryngeal cancer: univariate and multivariate analysis of prognostic factors. 38
16027286 2005
42
Horizontal partial laryngectomy for supraglottic squamous cell carcinoma. 38
15316823 2005
43
[Pathological feature and management of occult lymphatic metastasis in supraglottic carcinoma]. 38
16429726 2005
44
Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging. 38
15286316 2004
45
c-myc and bcl-2 Expression in supraglottic squamous cell carcinoma of the larynx. 38
15243561 2004
46
Parathyroid hormone-related peptide as a cause of hypercalcemia in squamous cell carcinoma of the head and neck: a case presentation and subject review. 38
15054743 2004
47
[Results of supraglottic partial horizontal laryngectomy]. 38
15080052 2003
48
[Detailed mapping and clinical significance of loss of heterozygosity on 9p13-23 in laryngeal squamous cell carcinoma by microsatellite analysis]. 38
12753701 2003
49
The distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications. 38
12369069 2002
50
Radioactive gold grain implants in recurrent and locally advanced head-and-neck cancers. 38
15090280 2002

Variations for Supraglottis Squamous Cell Carcinoma

Cosmic variations for Supraglottis Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM521 KRAS upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.35G>A p.G12D 12:25245350-25245350 0

Expression for Supraglottis Squamous Cell Carcinoma

Search GEO for disease gene expression data for Supraglottis Squamous Cell Carcinoma.

Pathways for Supraglottis Squamous Cell Carcinoma

GO Terms for Supraglottis Squamous Cell Carcinoma

Biological processes related to Supraglottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 8.62 NOS2 FGF2

Sources for Supraglottis Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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