MCID: SPR023
MIFTS: 23

Supraglottis Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Supraglottis Squamous Cell Carcinoma

MalaCards integrated aliases for Supraglottis Squamous Cell Carcinoma:

Name: Supraglottis Squamous Cell Carcinoma 12
Epidermoid Carcinoma of the Supraglottis 12
Supraglottic Squamous Cell Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7587
NCIt 50 C4945
UMLS 71 C0749163

Summaries for Supraglottis Squamous Cell Carcinoma

MalaCards based summary : Supraglottis Squamous Cell Carcinoma, also known as epidermoid carcinoma of the supraglottis, is related to microvascular complications of diabetes 5 and ischemia. An important gene associated with Supraglottis Squamous Cell Carcinoma is NOS2 (Nitric Oxide Synthase 2), and among its related pathways/superpathways are Pathways in cancer and Immune response IL-23 signaling pathway. Affiliated tissues include lymph node, bone marrow and endothelial.

Related Diseases for Supraglottis Squamous Cell Carcinoma

Diseases related to Supraglottis Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 9.7 NOS2 FGF2
2 ischemia 9.7 NOS2 FGF2
3 nervous system disease 9.7 NOS2 FGF2
4 vascular disease 9.6 NOS2 FGF2
5 pulmonary hypertension 9.6 NOS2 FGF2
6 lipoprotein quantitative trait locus 9.5 NOS2 FGF2

Graphical network of the top 20 diseases related to Supraglottis Squamous Cell Carcinoma:



Diseases related to Supraglottis Squamous Cell Carcinoma

Symptoms & Phenotypes for Supraglottis Squamous Cell Carcinoma

Drugs & Therapeutics for Supraglottis Squamous Cell Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Local Control 2 Years After Robot-assisted Supraglottic Laryngectomy: a Multicenter Retrospective Study Completed NCT03357107
2 A Single Arm Study of Efficacy and Functional Quality of Life in Patients Treated With Transoral Robotic Surgery for Oropharyngeal and Supraglottic Squamous Cell Carcinoma Recruiting NCT01819480
3 Radiotherapy Versus Elective Neck Dissection for Management of Cervical Nodes in Clinical T1/2N0 Supraglottic Squamous Cell Carcinoma Not yet recruiting NCT03358602

Search NIH Clinical Center for Supraglottis Squamous Cell Carcinoma

Genetic Tests for Supraglottis Squamous Cell Carcinoma

Anatomical Context for Supraglottis Squamous Cell Carcinoma

MalaCards organs/tissues related to Supraglottis Squamous Cell Carcinoma:

40
Lymph Node, Bone Marrow, Endothelial, Pituitary

Publications for Supraglottis Squamous Cell Carcinoma

Articles related to Supraglottis Squamous Cell Carcinoma:

(show top 50) (show all 82)
# Title Authors PMID Year
1
[Inducible nitric oxide synthase and basic fibroblast growth factor expression as prognostic factors in supraglottic squamous cell carcinoma]. 54 61
12969533 2003
2
[Expression of inducible nitric oxide synthase and basic fibroblast growth factor in supraglottic squamous cell carcinoma and their clinical significance]. 54 61
12508542 2002
3
Supraglottic Carcinoma in Intravenous Opioid Drug Abusers: A Distinct Disease with Improved Survival. 61
32946621 2020
4
Surgical, Oncological, and Functional Outcomes of Transoral Robotic Supraglottic Laryngectomy. 61
32812245 2020
5
Screening of molecular markers of induced chemotherapy in supraglottic laryngeal squamouscell carcinoma. 61
32426701 2020
6
Patterns of Cervical Lymph Node Metastasis in Locally Advanced Supraglottic Squamous Cell Carcinoma: Implications for Neck CTV Delineation. 61
32984023 2020
7
Craniocerebral metastases from a supraglottic squamous cell carcinoma: A case report and literature review. 61
31893049 2019
8
Hypopharyngeal Skin Cancer Following Total Laryngectomy and Pectoralis Flap Reconstruction: Case Report and Literature Review. 61
30888639 2019
9
Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases. 61
30536822 2019
10
Oncologic outcomes with transoral robotic surgery for supraglottic squamous cell carcinoma: Results of the French Robotic Surgery Group of GETTEC. 61
30051531 2018
11
The role of E-cadherin and β-catenin in laryngeal cancer. 61
30046398 2018
12
Intravenous opioid drug abuse as an independent risk factor for supraglottic squamous cell carcinoma-A case-control study. 61
28950046 2018
13
Treatment of early stage Supraglottic squamous cell carcinoma: meta-analysis comparing primary surgery versus primary radiotherapy. 61
29506564 2018
14
CO2 Transoral Microsurgery for Supraglottic Squamous Cell Carcinoma. 61
30234007 2018
15
Rate of Occult Cervical Lymph Node Involvement in Supraglottic Squamous Cell Carcinoma. 61
28589106 2017
16
PD-L1 expressing circulating tumour cells in head and neck cancers. 61
28511705 2017
17
Treatment results of alternating chemoradiotherapy with early assessment for advanced laryngeal cancer: A multi-institutional phase II study. 61
27435048 2017
18
Supraglottic squamous cell carcinomas have distinctive clinical features and prognosis based on subregion. 61
29155864 2017
19
Functional outcomes of supraglottic squamous cell carcinoma treated by transoral laser microsurgery compared with horizontal supraglottic laryngectomy in patients younger and older than 65 years. 61
28177327 2016
20
Transoral laser microsurgery for locally advanced (T3-T4a) supraglottic squamous cell carcinoma: Sixteen years of experience. 61
26872432 2016
21
Clinical outcomes with transoral robotic surgery for supraglottic squamous cell carcinoma: Experience of a French evaluation cooperative subgroup of GETTEC. 61
26435046 2016
22
The role of primary transoral laser microsurgery in laryngeal cancer: a retrospective study. 61
25704647 2015
23
Laryngopyocele: Presenting with pressure symptom. 61
26539381 2015
24
Distant bone metastasis from supraglottic squamous cell carcinoma. 61
25223573 2015
25
Clinical outcomes of transoral robotic surgery for supraglottic squamous cell carcinoma: experience of a french evaluation cooperative subgroup of gettec. 61
26891530 2015
26
Robotic-assisted salvage supraglottic laryngectomy. 61
24964644 2014
27
Survival differences between organ preservation surgery and definitive radiotherapy in early supraglottic squamous cell carcinoma. 61
24255085 2014
28
Late Prevertebral and Spinal Abscess following Chemoradiation for Laryngeal Squamous Cell Carcinoma. 61
24716067 2014
29
Analysis of multicentricity in supraglottic laryngeal carcinoma treated with partial laryngeal surgery. 61
23053372 2013
30
Functional swallowing outcomes following transoral robotic surgery vs primary chemoradiotherapy in patients with advanced-stage oropharynx and supraglottis cancers. 61
23247974 2013
31
Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma. 61
23151319 2012
32
Transoral robotic surgery for supraglottic squamous cell carcinoma. 61
22133967 2012
33
Oncologic outcomes after supracricoid partial laryngectomy. 61
21493316 2011
34
Hypopituitarism caused by pituitary metastasis of supraglottic laryngeal carcinoma: case report. 61
21462828 2010
35
Role of concurrent chemoradiation in laryngeal preservation for supraglottic cancer. 61
20211100 2010
36
Endoscopic horizontal partial laryngectomy by CO(2) laser in the management of supraglottic squamous cell carcinoma. 61
19360749 2009
37
Endoscopic partial supraglottic laryngectomies: techniques and results. 61
19716017 2009
38
Prognostic significance of vascular endothelial growth factor-C expression and lymphatic vessel density in supraglottic squamous cell carcinoma. 61
19444880 2009
39
Expression profiling of supraglottic carcinoma: PTEN and thrombospondin 2 are associated with inhibition of lymphatic metastasis. 61
18720079 2009
40
Efficacy of diagnostic upper node evaluation during (salvage) laryngectomy for supraglottic carcinoma. 61
19031402 2009
41
Supraglottic carcinoma treatment results analysed by therapeutic approach. 61
19460215 2009
42
Overexpression of Cap43 gene in supraglottic laryngeal squamous cell carcinoma. 61
19460198 2009
43
Mixed laryngocele: a case report and review of the literature. 61
18198756 2007
44
Supracricoid laryngectomies: long-term oncological and functional results. 61
16720450 2006
45
Efficacy of routine bilateral neck dissection in the management of the N0 neck in T1-T2 unilateral supraglottic cancer. 61
16419080 2006
46
Supracricoid partial laryngectomy in the treatment of laryngeal cancer: univariate and multivariate analysis of prognostic factors. 61
16027286 2005
47
Horizontal partial laryngectomy for supraglottic squamous cell carcinoma. 61
15316823 2005
48
[Pathological feature and management of occult lymphatic metastasis in supraglottic carcinoma]. 61
16429726 2005
49
Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging. 61
15286316 2004
50
c-myc and bcl-2 Expression in supraglottic squamous cell carcinoma of the larynx. 61
15243561 2004

Variations for Supraglottis Squamous Cell Carcinoma

Expression for Supraglottis Squamous Cell Carcinoma

Search GEO for disease gene expression data for Supraglottis Squamous Cell Carcinoma.

Pathways for Supraglottis Squamous Cell Carcinoma

Pathways related to Supraglottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.09 NOS2 FGF2
2
Show member pathways
11.85 NOS2 FGF2
3
Show member pathways
11.72 NOS2 FGF2
4
Show member pathways
11.45 NOS2 FGF2
5 11.34 NOS2 FGF2
6 10.68 NOS2 FGF2

GO Terms for Supraglottis Squamous Cell Carcinoma

Biological processes related to Supraglottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 8.96 NOS2 FGF2
2 cytokine-mediated signaling pathway GO:0019221 8.62 NOS2 FGF2

Sources for Supraglottis Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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