MCID: SPR023
MIFTS: 22

Supraglottis Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Supraglottis Squamous Cell Carcinoma

MalaCards integrated aliases for Supraglottis Squamous Cell Carcinoma:

Name: Supraglottis Squamous Cell Carcinoma 12
Epidermoid Carcinoma of the Supraglottis 12
Supraglottic Squamous Cell Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7587
NCIt 49 C4945
UMLS 71 C0749163

Summaries for Supraglottis Squamous Cell Carcinoma

MalaCards based summary : Supraglottis Squamous Cell Carcinoma, also known as epidermoid carcinoma of the supraglottis, is related to microvascular complications of diabetes 5 and ischemia. An important gene associated with Supraglottis Squamous Cell Carcinoma is NOS2 (Nitric Oxide Synthase 2), and among its related pathways/superpathways are Pathways in cancer and Immune response IL-23 signaling pathway. Affiliated tissues include lymph node, bone and bone marrow.

Related Diseases for Supraglottis Squamous Cell Carcinoma

Diseases related to Supraglottis Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 4, show less)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 9.5 NOS2 FGF2
2 ischemia 9.5 NOS2 FGF2
3 pulmonary hypertension 9.4 NOS2 FGF2
4 vascular disease 9.2 NOS2 FGF2

Symptoms & Phenotypes for Supraglottis Squamous Cell Carcinoma

Drugs & Therapeutics for Supraglottis Squamous Cell Carcinoma

Interventional clinical trials:

(showing 3, show less)
# Name Status NCT ID Phase Drugs
1 Evaluation of Local Control 2 Years After Robot-assisted Supraglottic Laryngectomy: a Multicenter Retrospective Study Completed NCT03357107
2 A Single Arm Study of Efficacy and Functional Quality of Life in Patients Treated With Transoral Robotic Surgery for Oropharyngeal and Supraglottic Squamous Cell Carcinoma Recruiting NCT01819480
3 Radiotherapy Versus Elective Neck Dissection for Management of Cervical Nodes in Clinical T1/2N0 Supraglottic Squamous Cell Carcinoma Not yet recruiting NCT03358602

Search NIH Clinical Center for Supraglottis Squamous Cell Carcinoma

Genetic Tests for Supraglottis Squamous Cell Carcinoma

Anatomical Context for Supraglottis Squamous Cell Carcinoma

MalaCards organs/tissues related to Supraglottis Squamous Cell Carcinoma:

40
Lymph Node, Bone, Bone Marrow, Skin, Endothelial, Pituitary

Publications for Supraglottis Squamous Cell Carcinoma

Articles related to Supraglottis Squamous Cell Carcinoma:

(showing 77, show less)
# Title Authors PMID Year
1
[Inducible nitric oxide synthase and basic fibroblast growth factor expression as prognostic factors in supraglottic squamous cell carcinoma]. 54 61
12969533 2003
2
[Expression of inducible nitric oxide synthase and basic fibroblast growth factor in supraglottic squamous cell carcinoma and their clinical significance]. 54 61
12508542 2002
3
Hypopharyngeal Skin Cancer Following Total Laryngectomy and Pectoralis Flap Reconstruction: Case Report and Literature Review. 61
30888639 2019
4
Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases. 61
30536822 2019
5
Oncologic outcomes with transoral robotic surgery for supraglottic squamous cell carcinoma: Results of the French Robotic Surgery Group of GETTEC. 61
30051531 2018
6
The role of E-cadherin and β-catenin in laryngeal cancer. 61
30046398 2018
7
Intravenous opioid drug abuse as an independent risk factor for supraglottic squamous cell carcinoma-A case-control study. 61
28950046 2018
8
Treatment of early stage Supraglottic squamous cell carcinoma: meta-analysis comparing primary surgery versus primary radiotherapy. 61
29506564 2018
9
CO2 Transoral Microsurgery for Supraglottic Squamous Cell Carcinoma. 61
30234007 2018
10
Rate of Occult Cervical Lymph Node Involvement in Supraglottic Squamous Cell Carcinoma. 61
28589106 2017
11
PD-L1 expressing circulating tumour cells in head and neck cancers. 61
28511705 2017
12
Treatment results of alternating chemoradiotherapy with early assessment for advanced laryngeal cancer: A multi-institutional phase II study. 61
27435048 2017
13
Supraglottic squamous cell carcinomas have distinctive clinical features and prognosis based on subregion. 61
29155864 2017
14
Functional outcomes of supraglottic squamous cell carcinoma treated by transoral laser microsurgery compared with horizontal supraglottic laryngectomy in patients younger and older than 65 years. 61
28177327 2016
15
Transoral laser microsurgery for locally advanced (T3-T4a) supraglottic squamous cell carcinoma: Sixteen years of experience. 61
26872432 2016
16
Clinical outcomes with transoral robotic surgery for supraglottic squamous cell carcinoma: Experience of a French evaluation cooperative subgroup of GETTEC. 61
26435046 2016
17
The role of primary transoral laser microsurgery in laryngeal cancer: a retrospective study. 61
25704647 2015
18
Laryngopyocele: Presenting with pressure symptom. 61
26539381 2015
19
Distant bone metastasis from supraglottic squamous cell carcinoma. 61
25223573 2015
20
Clinical outcomes of transoral robotic surgery for supraglottic squamous cell carcinoma: experience of a french evaluation cooperative subgroup of gettec. 61
26891530 2015
21
Robotic-assisted salvage supraglottic laryngectomy. 61
24964644 2014
22
Survival differences between organ preservation surgery and definitive radiotherapy in early supraglottic squamous cell carcinoma. 61
24255085 2014
23
Late Prevertebral and Spinal Abscess following Chemoradiation for Laryngeal Squamous Cell Carcinoma. 61
24716067 2014
24
Analysis of multicentricity in supraglottic laryngeal carcinoma treated with partial laryngeal surgery. 61
23053372 2013
25
Functional swallowing outcomes following transoral robotic surgery vs primary chemoradiotherapy in patients with advanced-stage oropharynx and supraglottis cancers. 61
23247974 2013
26
Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma. 61
23151319 2012
27
Transoral robotic surgery for supraglottic squamous cell carcinoma. 61
22133967 2012
28
Oncologic outcomes after supracricoid partial laryngectomy. 61
21493316 2011
29
Hypopituitarism caused by pituitary metastasis of supraglottic laryngeal carcinoma: case report. 61
21462828 2010
30
Role of concurrent chemoradiation in laryngeal preservation for supraglottic cancer. 61
20211100 2010
31
Endoscopic partial supraglottic laryngectomies: techniques and results. 61
19716017 2009
32
Endoscopic horizontal partial laryngectomy by CO(2) laser in the management of supraglottic squamous cell carcinoma. 61
19360749 2009
33
Prognostic significance of vascular endothelial growth factor-C expression and lymphatic vessel density in supraglottic squamous cell carcinoma. 61
19444880 2009
34
Expression profiling of supraglottic carcinoma: PTEN and thrombospondin 2 are associated with inhibition of lymphatic metastasis. 61
18720079 2009
35
Efficacy of diagnostic upper node evaluation during (salvage) laryngectomy for supraglottic carcinoma. 61
19031402 2009
36
Supraglottic carcinoma treatment results analysed by therapeutic approach. 61
19460215 2009
37
Overexpression of Cap43 gene in supraglottic laryngeal squamous cell carcinoma. 61
19460198 2009
38
Mixed laryngocele: a case report and review of the literature. 61
18198756 2007
39
Efficacy of routine bilateral neck dissection in the management of the N0 neck in T1-T2 unilateral supraglottic cancer. 61
16419080 2006
40
Supracricoid laryngectomies: long-term oncological and functional results. 61
16720450 2006
41
Supracricoid partial laryngectomy in the treatment of laryngeal cancer: univariate and multivariate analysis of prognostic factors. 61
16027286 2005
42
Horizontal partial laryngectomy for supraglottic squamous cell carcinoma. 61
15316823 2005
43
[Pathological feature and management of occult lymphatic metastasis in supraglottic carcinoma]. 61
16429726 2005
44
Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging. 61
15286316 2004
45
c-myc and bcl-2 Expression in supraglottic squamous cell carcinoma of the larynx. 61
15243561 2004
46
Parathyroid hormone-related peptide as a cause of hypercalcemia in squamous cell carcinoma of the head and neck: a case presentation and subject review. 61
15054743 2004
47
[Results of supraglottic partial horizontal laryngectomy]. 61
15080052 2003
48
[Detailed mapping and clinical significance of loss of heterozygosity on 9p13-23 in laryngeal squamous cell carcinoma by microsatellite analysis]. 61
12753701 2003
49
The distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications. 61
12369069 2002
50
Radioactive gold grain implants in recurrent and locally advanced head-and-neck cancers. 61
15090280 2002
51
Concurrent chemotherapy and radiotherapy as initial treatment for stage II supraglottic squamous cell carcinoma. 61
11683352 2001
52
Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy. 61
11131380 2000
53
The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx. 61
10748452 2000
54
Transcutaneous fine needle aspiration biopsy of the preepiglottic space. 61
10740600 2000
55
Laryngeal long-term morbidity after supraglottic laryngectomy and postoperative radiation therapy. 61
10668672 2000
56
Histopathological predictors of occult lymph node metastases in supraglottic squamous cell carcinomas. 61
11052252 2000
57
Patterns of nodal metastasis and surgical management of the neck in supraglottic laryngeal carcinoma. 61
10388879 1999
58
Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. 61
10386632 1999
59
Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma. 61
10080608 1999
60
Oncological and functional outcome of conservative surgery for primary supraglottic cancer. 61
10456276 1999
61
Tumour volume: implications in T2/T3 glottic/supraglottic squamous cell carcinoma. 61
9800621 1998
62
Stridor as a manifestation of supraglottic carcinoma in a patient with AIDS. 61
9499268 1998
63
Prognostic value of hemoglobin concentration in radiotherapy for cancer of supraglottic larynx. 61
9276366 1997
64
Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx. 61
8931613 1996
65
Squamous cell carcinoma of the pharynx and larynx presenting as a neck abscess or cellulitis. 61
8949308 1996
66
Evaluation of HER-2/neu (c-erbB-2) oncogene expression in whole organ sections of supraglottic squamous cell carcinoma. 61
8604888 1996
67
[External radiotherapy in early stage squamous cell carcinoma of the supraglottic larynx. Report of 28 cases]. 61
8984838 1996
68
Osteoradionecrosis of the hyoid induced by combined modality therapy for laryngeal carcinoma. 61
7555876 1995
69
[Pre-operative radiotherapy for N0 supraglottic carcinoma: a randomized study]. 61
8745456 1995
70
[Detection of neck lymph node metastasis in the patients with supraglottic cancer]. 61
7598987 1995
71
Pearson near-total laryngectomy: a reproducible speaking shunt. 61
8056576 1994
72
[Incidence and distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications]. 61
8036885 1994
73
Penile metastasis secondary to supraglottic squamous cell carcinoma: review of the literature. 61
1729515 1992
74
Concomitant boost radiotherapy of supraglottic cancer--preliminary results, morbidity. 61
1528309 1992
75
Supraglottic carcinoma: patterns of recurrence. 61
2294829 1990
76
Metastatic bone marrow involvement from supraglottic squamous cell carcinoma. 61
2926274 1989
77
Evaluation of randomized preoperative and postoperative radiation therapy for supraglottic carcinoma. Preliminary report. 61
718066 1978

Variations for Supraglottis Squamous Cell Carcinoma

Cosmic variations for Supraglottis Squamous Cell Carcinoma:

9 (showing 1, show less)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM143183345 upper aerodigestive tract,supraglottis,carcinoma,squamous cell carcinoma c.470C>T p.P157L 17:7673581-7673581 0

Expression for Supraglottis Squamous Cell Carcinoma

Search GEO for disease gene expression data for Supraglottis Squamous Cell Carcinoma.

Pathways for Supraglottis Squamous Cell Carcinoma

Pathways related to Supraglottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(showing 4, show less)
# Super pathways Score Top Affiliating Genes
1 11.98 NOS2 FGF2
2
Show member pathways
11.69 NOS2 FGF2
3
Show member pathways
11.25 NOS2 FGF2
4 10.68 NOS2 FGF2

GO Terms for Supraglottis Squamous Cell Carcinoma

Biological processes related to Supraglottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 8.62 NOS2 FGF2

Sources for Supraglottis Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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