MCID: SPR024
MIFTS: 49

Supratentorial Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Supratentorial Cancer

MalaCards integrated aliases for Supratentorial Cancer:

Name: Supratentorial Cancer 12 15
Supratentorial Neoplasms 44 73
Brain Neoplasm, Supratentorial 12
Malignant Supratentorial Tumor 12
Cancer, Supratentorial 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1659
ICD10 33 C71.0
MeSH 44 D015173
NCIt 50 C3397 C4964

Summaries for Supratentorial Cancer

Disease Ontology : 12 A brain cancer that is located in the supratentorial region.

MalaCards based summary : Supratentorial Cancer, also known as supratentorial neoplasms, is related to cerebrum cancer and brain ependymoma. An important gene associated with Supratentorial Cancer is TP53 (Tumor Protein P53), and among its related pathways/superpathways are ERK Signaling and Human cytomegalovirus infection. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Supratentorial Cancer

Diseases related to Supratentorial Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 cerebrum cancer 30.4 AKT1 ATRX CDKN2A EGFR GFAP H3F3A
2 brain ependymoma 10.4 EGFR TP53
3 cerebral convexity meningioma 10.4 GFAP TP53
4 enchondroma 10.4 IDH1 IDH2
5 rare adenocarcinoma of the breast 10.4 AKT1 TP53
6 anaplastic ganglioglioma 10.4 GFAP NES
7 pharynx squamous cell carcinoma 10.4 AKT1 PTEN
8 preretinal fibrosis 10.4 GFAP VEGFA
9 mucinous stomach adenocarcinoma 10.4 PTEN VEGFA
10 bladder squamous cell carcinoma 10.4 CDKN2A TP53
11 malignant peritoneal mesothelioma 10.4 CDKN2A EGFR
12 lung combined type small cell carcinoma 10.4 GFAP SYP
13 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
14 sinonasal undifferentiated carcinoma 10.4 IDH2 SYP
15 uterine carcinosarcoma 10.4 EGFR PTEN TP53
16 infiltrating angiolipoma 10.3 CDKN2A VEGFA
17 ductal carcinoma in situ 10.3 AKT1 EGFR TP53
18 estrogen-receptor positive breast cancer 10.3 AKT1 EGFR TP53
19 malignant glandular tumor of peripheral nerve sheath 10.3 NF1 SYP
20 prostate disease 10.3 AKT1 PTEN TP53
21 colorectal adenocarcinoma 10.3 EGFR TP53 VEGFA
22 bile duct cancer 10.3 EGFR TP53 VEGFA
23 differentiated thyroid carcinoma 10.3 EGFR TP53 VEGFA
24 oligoastrocytoma 10.3 GFAP IDH2 MGMT
25 intracranial chondrosarcoma 10.3 IDH1 IDH2 TP53
26 mixed glioma 10.3 GFAP IDH1 TP53
27 gonadal disease 10.3 AKT1 TP53 VEGFA
28 oral cancer 10.3 CDKN2A EGFR TP53
29 protoplasmic astrocytoma 10.3 GFAP IDH2 TP53
30 cerebellar astrocytoma 10.3 IDH1 KIAA1549 TP53
31 gliofibroma 10.3 GFAP NF1 TP53
32 bladder disease 10.3 AKT1 CDKN2A TP53
33 tongue squamous cell carcinoma 10.3 AKT1 CDKN2A TP53
34 gemistocytic astrocytoma 10.3 GFAP IDH2 PTEN
35 ependymoblastoma 10.3 GFAP NES TP53
36 adult oligodendroglioma 10.3 IDH1 IDH2 NF1
37 frontal convexity meningioma 10.3 GFAP TP53
38 ocular cancer 10.3 CDKN2A SOX2 TP53
39 interval angle-closure glaucoma 10.3 IDH1 IDH2
40 extraventricular neurocytoma 10.3 GFAP IDH1 SYP
41 cellular ependymoma 10.3 GFAP SYP TP53
42 hemangioblastoma 10.3 GFAP SYP VEGFA
43 cell type benign neoplasm 10.3 CDKN2A SYP TP53
44 cerebral neuroblastoma 10.3 GFAP SYP TP53
45 central nervous system germ cell tumor 10.3 GFAP NES SOX2
46 soft tissue sarcoma 10.3 EGFR TP53 VEGFA
47 choroid plexus cancer 10.3 ATRX GFAP TP53
48 cerebral ventricle cancer 10.3 GFAP SYP TP53
49 gastric adenosquamous carcinoma 10.3 CDKN2A PROM1 TP53
50 angiocentric glioma 10.3 GFAP IDH1 SYP

Graphical network of the top 20 diseases related to Supratentorial Cancer:



Diseases related to Supratentorial Cancer

Symptoms & Phenotypes for Supratentorial Cancer

GenomeRNAi Phenotypes related to Supratentorial Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.92 EGFR
2 Decreased viability GR00221-A-1 9.92 AKT1 CDKN2A EGFR NF1 SOX2
3 Decreased viability GR00221-A-2 9.92 AKT1 NF1
4 Decreased viability GR00221-A-3 9.92 AKT1 CDKN2A
5 Decreased viability GR00221-A-4 9.92 AKT1 CDKN2A EGFR NF1 SOX2
6 Decreased viability GR00402-S-2 9.92 AKT1 CDKN2A EGFR NF1 SOX2
7 Decreased p24 protein expression GR00163-A-1 9.46 AKT1 EGFR H3F3A IDH1
8 Decreased sensitivity to paclitaxel GR00112-A-0 8.96 NF1 PTEN

MGI Mouse Phenotypes related to Supratentorial Cancer:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.42 AKT1 ATRX CDKN2A GFAP KIAA1549 NF1
2 cellular MP:0005384 10.4 AKT1 ATRX CDKN2A EGFR GFAP H3F3B
3 growth/size/body region MP:0005378 10.4 AKT1 ATRX CDKN2A EGFR GFAP H3F3B
4 mortality/aging MP:0010768 10.37 AKT1 ATRX CDKN2A EGFR GFAP H3F3B
5 cardiovascular system MP:0005385 10.34 AKT1 ATRX CDKN2A EGFR GFAP IDH2
6 homeostasis/metabolism MP:0005376 10.33 AKT1 CDKN2A EGFR GFAP IDH1 KIAA1549
7 immune system MP:0005387 10.28 AKT1 CDKN2A EGFR GFAP IDH1 KIAA1549
8 embryo MP:0005380 10.27 AKT1 ATRX CDKN2A EGFR H3F3B NF1
9 nervous system MP:0003631 10.25 AKT1 ATRX CDKN2A EGFR GFAP NF1
10 neoplasm MP:0002006 10.23 AKT1 CDKN2A EGFR IDH2 MGMT NF1
11 endocrine/exocrine gland MP:0005379 10.22 AKT1 CDKN2A EGFR MGMT NF1 PTEN
12 digestive/alimentary MP:0005381 10.19 CDKN2A EGFR GFAP NF1 PTEN SOX2
13 muscle MP:0005369 10.18 AKT1 CDKN2A EGFR GFAP NF1 OLIG2
14 integument MP:0010771 10.13 AKT1 CDKN2A EGFR NF1 PTEN SOX2
15 normal MP:0002873 10.11 AKT1 EGFR GFAP H3F3B NF1 PROM1
16 liver/biliary system MP:0005370 10.05 AKT1 CDKN2A EGFR NF1 PTEN TP53
17 no phenotypic analysis MP:0003012 10.01 CDKN2A EGFR MGMT OLIG2 PROM1 SOX2
18 reproductive system MP:0005389 9.91 AKT1 ATRX CDKN2A EGFR H3F3B PTEN
19 respiratory system MP:0005388 9.9 AKT1 CDKN2A EGFR IDH1 MGMT NF1
20 pigmentation MP:0001186 9.87 CDKN2A EGFR NF1 PROM1 PTEN SOX2
21 skeleton MP:0005390 9.65 AKT1 CDKN2A EGFR IDH1 NF1 OLIG2
22 vision/eye MP:0005391 9.36 ATRX CDKN2A EGFR GFAP NF1 OLIG2

Drugs & Therapeutics for Supratentorial Cancer

Drugs for Supratentorial Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
3
Lonafarnib Investigational Phase 1 193275-84-2 148195
4 Antineoplastic Agents, Alkylating Phase 1
5 Alkylating Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lonafarnib and Temozolomide in Treating Patients With Glioblastoma Multiforme That Is Recurrent or Did Not Respond to Previous Treatment With Temozolomide Active, not recruiting NCT00102648 Phase 1 Lonafarnib;Temozolomide

Search NIH Clinical Center for Supratentorial Cancer

Cochrane evidence based reviews: supratentorial neoplasms

Genetic Tests for Supratentorial Cancer

Anatomical Context for Supratentorial Cancer

MalaCards organs/tissues related to Supratentorial Cancer:

41
Brain, Lung, Bone, Colon, Tongue, Spinal Cord, Cerebellum

Publications for Supratentorial Cancer

Articles related to Supratentorial Cancer:

# Title Authors Year
1
Intraoperative electrocorticography-guided microsurgical management for patients with onset of supratentorial neoplasms manifesting as epilepsy: a review of 65 cases. ( 24866815 )
2014
2
Effect of intraoperative glucose fluctuation and postoperative IL-6, TNF-α, CRP levels on the short-term prognosis of patients with intracranial supratentorial neoplasms. ( 25605194 )
2014
3
Expression of oncoprotein Bcl-2 and bax protein in the infiltration zone and in the parenchyma of primary glia-derived supratentorial neoplasms. ( 10323081 )
1998
4
Thallium-201-SPECT and 99Tc-HM-PAO SPECT imaging to study functionally cerebral supratentorial neoplasms: the biological basis of the functional imaging interpretation. ( 8803843 )
1995
5
Supratentorial neoplasms, including the sella and parasellar region. ( 2624769 )
1989
6
Specificity of computed tomography in the diagnosis of supratentorial neoplasms. Consideration of metastases and meningiomas. ( 745752 )
1978
7
Carotid angiography in the localisation of supratentorial neoplasms and hamartomata. ( 13624051 )
1959

Variations for Supratentorial Cancer

Expression for Supratentorial Cancer

Search GEO for disease gene expression data for Supratentorial Cancer.

Pathways for Supratentorial Cancer

Pathways related to Supratentorial Cancer according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 AKT1 CDKN2A EGFR GFAP H3F3A H3F3B
2
Show member pathways
13.01 AKT1 CDKN2A EGFR PTEN TP53 VEGFA
3
Show member pathways
12.78 AKT1 CDKN2A EGFR PTEN TP53 VEGFA
4 12.72 AKT1 EGFR NF1 TP53 VEGFA
5
Show member pathways
12.72 AKT1 CDKN2A EGFR PTEN TP53
6 12.72 AKT1 CDKN2A EGFR PTEN TP53 VEGFA
7
Show member pathways
12.54 AKT1 CDKN2A EGFR NF1 PTEN TP53
8 12.42 CDKN2A EGFR PTEN TP53 VEGFA
9 12.25 AKT1 EGFR TP53 VEGFA
10 12.21 H3F3A H3F3B PROM1 TP53
11
Show member pathways
12.17 AKT1 EGFR PTEN VEGFA
12
Show member pathways
12.15 AKT1 EGFR PTEN TP53
13 12.12 AKT1 EGFR TP53 VEGFA
14 12.09 AKT1 EGFR PTEN TP53
15 12.09 AKT1 CDKN2A PTEN TP53
16 11.99 NES PROM1 SOX2 VEGFA
17 11.92 AKT1 EGFR NF1 PTEN TP53 VEGFA
18 11.87 AKT1 CDKN2A PTEN TP53
19
Show member pathways
11.86 AKT1 EGFR H3F3A H3F3B TP53
20 11.84 AKT1 SOX2 TP53 VEGFA
21 11.82 AKT1 PTEN TP53
22 11.81 AKT1 EGFR PTEN
23 11.77 AKT1 PTEN TP53
24 11.7 AKT1 CDKN2A TP53
25
Show member pathways
11.7 AKT1 CDKN2A TP53
26 11.6 CDKN2A EGFR TP53 VEGFA
27 11.55 AKT1 CDKN2A EGFR MGMT NF1 PTEN
28 11.54 AKT1 PTEN TP53
29 11.53 CDKN2A TP53 VEGFA
30 11.52 AKT1 ATRX PTEN TP53
31 11.49 AKT1 TP53 VEGFA
32 11.49 CDKN2A EGFR TP53
33 11.45 EGFR NF1 VEGFA
34 11.41 AKT1 PTEN TP53
35 11.37 AKT1 EGFR IDH1 PTEN TP53
36 11.17 EGFR H3F3A H3F3B TP53
37 11.15 AKT1 EGFR PROM1
38 11.06 GFAP NES OLIG2 PROM1 SOX2 SYP
39
Show member pathways
10.79 IDH1 IDH2

GO Terms for Supratentorial Cancer

Cellular components related to Supratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Barr body GO:0001740 8.96 H3F3A H3F3B
2 nuclear chromosome GO:0000228 8.8 ATRX H3F3A H3F3B

Biological processes related to Supratentorial Cancer according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.99 AKT1 EGFR MGMT PTEN TP53 VEGFA
2 brain development GO:0007420 9.95 H3F3A H3F3B NES NF1
3 positive regulation of apoptotic process GO:0043065 9.95 AKT1 CDKN2A NF1 PTEN TP53
4 multicellular organism growth GO:0035264 9.83 ATRX H3F3A H3F3B
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 AKT1 EGFR VEGFA
6 negative regulation of protein kinase activity GO:0006469 9.82 AKT1 CDKN2A NF1
7 positive regulation of endothelial cell proliferation GO:0001938 9.81 AKT1 NF1 VEGFA
8 response to organic cyclic compound GO:0014070 9.8 EGFR IDH1 MGMT PTEN
9 Ras protein signal transduction GO:0007265 9.79 CDKN2A NF1 TP53
10 response to hormone GO:0009725 9.76 AKT1 H3F3A H3F3B
11 cellular response to hypoxia GO:0071456 9.73 AKT1 PTEN TP53 VEGFA
12 mammary gland epithelial cell differentiation GO:0060644 9.67 AKT1 MGMT
13 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.67 MGMT SOX2
14 replicative senescence GO:0090399 9.66 CDKN2A TP53
15 negative regulation of cell size GO:0045792 9.64 AKT1 PTEN
16 forebrain morphogenesis GO:0048853 9.63 NF1 PTEN
17 NADP metabolic process GO:0006739 9.62 IDH1 IDH2
18 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.62 EGFR TP53
19 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.58 CDKN2A PTEN
20 DNA replication-independent nucleosome assembly GO:0006336 9.58 ATRX H3F3A H3F3B
21 obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.57 AKT1 EGFR
22 isocitrate metabolic process GO:0006102 9.56 IDH1 IDH2
23 cellular response to decreased oxygen levels GO:0036294 9.54 AKT1 PTEN
24 pericentric heterochromatin assembly GO:0031508 9.52 H3F3A H3F3B
25 regulation of centromere complex assembly GO:0090230 9.48 H3F3A H3F3B
26 response to UV-A GO:0070141 9.46 AKT1 EGFR
27 positive regulation of cell growth GO:0030307 9.46 AKT1 EGFR H3F3A H3F3B
28 cell proliferation GO:0008283 9.43 AKT1 EGFR H3F3A H3F3B PTEN TP53
29 glyoxylate cycle GO:0006097 9.37 IDH1 IDH2
30 negative regulation of chromosome condensation GO:1902340 9.32 H3F3A H3F3B
31 telomeric heterochromatin assembly GO:0031509 9.26 H3F3A H3F3B
32 osteoblast differentiation GO:0001649 9.02 AKT1 H3F3A H3F3B NF1 SOX2
33 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 AKT1 ATRX CDKN2A EGFR SOX2 TP53
34 multicellular organism development GO:0007275 10.14 AKT1 EGFR NES OLIG2 SOX2 TP53
35 nervous system development GO:0007399 10.04 AKT1 NES OLIG2 PTEN VEGFA
36 positive regulation of gene expression GO:0010628 10 AKT1 CDKN2A PTEN TP53 VEGFA

Molecular functions related to Supratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.77 EGFR H3F3A H3F3B TP53 VEGFA
2 protein kinase binding GO:0019901 9.65 AKT1 CDKN2A EGFR PTEN TP53
3 nitric-oxide synthase regulator activity GO:0030235 9.32 AKT1 EGFR
4 identical protein binding GO:0042802 9.23 AKT1 EGFR GFAP IDH1 PTEN SYP
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.16 IDH1 IDH2
6 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2

Sources for Supratentorial Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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