MCID: SPR024
MIFTS: 38

Supratentorial Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Supratentorial Cancer

MalaCards integrated aliases for Supratentorial Cancer:

Name: Supratentorial Cancer 12 15
Supratentorial Neoplasms 44 70
Brain Neoplasm, Supratentorial 12
Malignant Supratentorial Tumor 12
Cancer, Supratentorial 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1659
MeSH 44 D015173
NCIt 50 C3397 C4964
ICD10 32 C71.0
UMLS 70 C0038874 C0751589

Summaries for Supratentorial Cancer

Disease Ontology : 12 A brain cancer that is located in the supratentorial region.

MalaCards based summary : Supratentorial Cancer, also known as supratentorial neoplasms, is related to cerebrum cancer and myoblastoma. An important gene associated with Supratentorial Cancer is SYP (Synaptophysin), and among its related pathways/superpathways are Translation Non-genomic (rapid) action of Androgen Receptor and Neuroscience. The drugs Morphine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and pineal, and related phenotypes are Decreased p24 protein expression and Increased proliferation

Related Diseases for Supratentorial Cancer

Diseases related to Supratentorial Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 cerebrum cancer 29.2 ZFTA YAP1 TP53 TAF12 SYP SMARCB1
2 myoblastoma 10.5 SYP ENO2
3 malignant melanocytic neoplasm of the peripheral nerve sheath 10.5 SYP ENO2
4 anal neuroendocrine tumor 10.5 SYP ENO2
5 rela fusion-positive ependymoma 10.5 ZFTA RELA
6 neuronal intestinal dysplasia, type b 10.5 SYP ENO2
7 monosomy 22 10.5 SMARCB1 NF2
8 lung combined type small cell carcinoma 10.5 SYP GFAP
9 intracranial cysts 10.5 GFAP ENO2
10 large cell carcinoma with rhabdoid phenotype 10.5 SMARCB1 ENO2
11 sinonasal undifferentiated carcinoma 10.5 SYP ENO2
12 posterior pituitary gland neoplasm 10.5 SMARCB1 GFAP
13 sarcomatoid transitional cell carcinoma 10.5 TP53 SYP
14 auditory system benign neoplasm 10.5 SYP ENO2
15 primitive neuroectodermal tumor of the cervix uteri 10.5 GFAP ENO2
16 papillary tumor of the pineal region 10.5 SYP ENO2
17 auditory system cancer 10.5 SYP ENO2
18 cloacogenic carcinoma 10.5 SYP ENO2
19 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.5 SYP ENO2
20 internal auditory canal lipoma 10.5 SMARCB1 IDH1
21 intracranial primitive neuroectodermal tumor 10.5 SYP ENO2
22 nodular prostate 10.5 SYP ENO2
23 third ventricle chordoid glioma 10.5 OLIG2 GFAP
24 ampulla of vater benign neoplasm 10.5 SYP ENO2
25 appendix carcinoid tumor 10.4 SYP ENO2
26 suprasellar meningioma 10.4 NF2 GFAP
27 urethra transitional cell carcinoma 10.4 TP53 GFAP
28 carotid body cancer 10.4 SYP ENO2
29 gallbladder small cell carcinoma 10.4 SYP ENO2
30 ureter small cell carcinoma 10.4 SYP ENO2
31 middle ear adenoma 10.4 SYP ENO2
32 urinary bladder small cell neuroendocrine carcinoma 10.4 SYP ENO2
33 gastric small cell carcinoma 10.4 SYP ENO2
34 cerebral falx meningioma 10.4 NF2 ENO2
35 jejunal neoplasm 10.4 SYP ENO2
36 sensory organ benign neoplasm 10.4 SYP ENO2
37 peripheral nerve schwannoma 10.4 SMARCB1 NF2
38 cerebral convexity meningioma 10.4 NF2 IDH1
39 optic nerve astrocytoma 10.4 SYP SMARCB1 ENO2
40 papillary ependymoma 10.4 SYP NF2 GFAP
41 pineal region teratoma 10.4 SYP SMARCB1 ENO2
42 ovarian large-cell neuroendocrine carcinoma 10.4 SYP ENO2
43 bile duct mucinous adenocarcinoma 10.4 TP53 SYP ENO2
44 cerebral neuroblastoma 10.4 SYP GFAP ENO2
45 gastric hemangioma 10.4 SYP ENO2
46 rhabdoid tumor predisposition syndrome 1 10.4 TP53 SMARCB1
47 kidney rhabdoid cancer 10.4 SYP SMARCB1 ENO2
48 psammomatous meningioma 10.4 NF2 ENO2
49 chiari malformation 10.4 SYP GFAP
50 cerebellopontine angle primitive neuroectodermal tumor 10.4 SYP GFAP ENO2

Graphical network of the top 20 diseases related to Supratentorial Cancer:



Diseases related to Supratentorial Cancer

Symptoms & Phenotypes for Supratentorial Cancer

GenomeRNAi Phenotypes related to Supratentorial Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased p24 protein expression GR00163-A-1 9.26 EGFR IDH1 NF2 RELA
2 Increased proliferation GR00094-A 8.8 NF2 SMARCB1 TP53

MGI Mouse Phenotypes related to Supratentorial Cancer:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.28 EGFR ENO2 GFAP IDH1 KCNJ13 MYCN
2 behavior/neurological MP:0005386 10.27 ENO2 GFAP KCNJ13 MYCN NF2 OLIG2
3 embryo MP:0005380 10.16 EGFR KCNJ13 MYCN NF2 RELA SHH
4 digestive/alimentary MP:0005381 10.13 EGFR GFAP KCNJ13 MYCN RELA SHH
5 nervous system MP:0003631 10.13 EGFR ENO2 GFAP MYCN NELL2 NF2
6 muscle MP:0005369 10.02 EGFR GFAP MYCN OLIG2 RELA SHH
7 liver/biliary system MP:0005370 10.01 EGFR MYCN NF2 RELA SHH SMARCB1
8 respiratory system MP:0005388 9.9 EGFR ENO2 IDH1 KCNJ13 MYCN NF2
9 neoplasm MP:0002006 9.87 EGFR NF2 OLIG2 SHH SMARCB1 TP53
10 skeleton MP:0005390 9.7 EGFR IDH1 KCNJ13 MYCN NF2 OLIG2
11 vision/eye MP:0005391 9.36 EGFR GFAP MYCN NF2 OLIG2 RELA

Drugs & Therapeutics for Supratentorial Cancer

Drugs for Supratentorial Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4 57-27-2 5288826
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
3 Dexketoprofen trometamol Phase 4
4 Antirheumatic Agents Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Anti-Inflammatory Agents, Non-Steroidal Phase 4
7 Pharmaceutical Solutions Phase 4
8 Narcotics Phase 4
9 Hypnotics and Sedatives Phase 4
10 Analgesics Phase 4
11 Analgesics, Opioid Phase 4
12 Analgesics, Non-Narcotic Phase 4
13 Adrenergic alpha-Agonists Phase 4
14 Adrenergic Agents Phase 4
15 Neurotransmitter Agents Phase 4
16 Adrenergic Agonists Phase 4
17
Sufentanil Approved, Investigational Phase 3 56030-54-7 41693
18
Sevoflurane Approved, Vet_approved Phase 3 28523-86-6 5206
19
Etoposide Approved Phase 2 33419-42-0 36462
20
Melphalan Approved Phase 2 148-82-3 4053 460612
21
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
22
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
23
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
24 Etoposide phosphate Phase 2
25
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
26
Lonafarnib Approved, Investigational Phase 1 193275-84-2 148195
27 Vaccines Phase 1
28 Alkylating Agents Phase 1
29
Racepinephrine Approved 329-65-7 838
30
Epinephrine Approved, Vet_approved 51-43-4 5816
31
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
32
Magnesium Sulfate Approved, Investigational, Vet_approved 7487-88-9 24083
33
Remifentanil Approved 132875-61-7 60815
34
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
35
Desflurane Approved 57041-67-5 42113
36
Mannitol Approved, Investigational 69-65-8 6251 453
37 Epinephryl borate
38 Anesthetics, Local
39 Anesthetics
40 Anesthetics, General
41 Anesthetics, Intravenous
42 Anesthetics, Inhalation
43 diuretics

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Comparison of Efficacy and Safety of the Postoperative Analgesia Methods for Supratentorial Craniotomy by Integrated Pulmonary Index (IPI) Unknown status NCT02929147 Phase 4 Morphine;Dexketoprofen;Placebo
2 Effect of Remifentanil Infusion Alone During the Closure Period for Early Emergence and Hemodynamic Stability in Patients Undergoing Supratentorial Craniotomy Completed NCT02593942 Phase 4 Remifentanil;Propofol
3 Efficacy of Dexmedetomidine Infusion Without Loading Dose on Hemodynamic Variables and Recovery Time During Craniotomy: A Randomized Double Blinded Controlled Study Completed NCT04607525 Phase 4 Dexmedetomidine;normal saline
4 Anaesthesia for Supratentorial Tumor Resection : a Double-blind Comparison of Target Plasma Concentration of Propofol-remifentanil and Sevoflurane-sufentanil Completed NCT00389883 Phase 3 Comparison of two anesthetics protocol
5 Phase II Prospective Study of Sequential Myeloablative Chemotherapy With Stem Cell Rescue for the Treatment of Selected High Risk CNS Tumors and Recurrent CNS Tumors Completed NCT00179803 Phase 2
6 Phase I Clinical Trial of HSV G207 Alone or With a Single Radiation Dose in Children With Recurrent Supratentorial Brain Tumors Active, not recruiting NCT02457845 Phase 1
7 Phase I/Ib Study of Sarasar and Temodar in Patients With Recurrent or Temodar-Refractory Glioblastoma Multiforme Active, not recruiting NCT00102648 Phase 1 Lonafarnib;Temozolomide
8 Can Mannitol Increments Provide More Brain Relaxation in Patients Undergoing Craniotomy for Supratentorial Brain Tumor Removal? Unknown status NCT02168075 0.25g/kgof 20% mannitol;0.5g/kg of 20% mannitol;1.0g/kg of 20% mannitol;1.5g/kg of 20% mannitol
9 Comparison of Stroke Volume Variation-guided Normovolemic and Restrictive Fluid Management During Craniotomy: a Randomized Controlled Trial Unknown status NCT02113358 Intravenous colloid bolus with Voluven
10 Randomized, Parallelled and Double-blinded Trial of Small-dose Dexmedetomidine Effects on Recovery Profiles of Supratentorial Tumors Patients From General Anesthesia Unknown status NCT02007798 dexmedetomidine;normal saline
11 Effect of Bilateral Scalp Nerve Blocks on Post-operative Pain and Discharge Times in Patients Undergoing Supra-tentorial Craniotomy and General Anaesthesia Completed NCT00972790
12 Spectrum of Serum Sodium Disturbances in Patients With Non-sellar/Suprasellar Supratentorial Tumors Completed NCT03570203
13 Study of the Depth of Anesthesia on Postoperative Clinical Outcome in Patients With Supratentorial Tumor Completed NCT03033693
14 Comparison of Equiosmolar Doses of Mannitol 20% Versus Hypertonic Saline 7.5% Infusion in the Reduction of Brain Bulk During Elective Craniotomies for Supratentorial Brain Tumor Resection Completed NCT00199511 Administration of Hypertonic Solution 7.5% vs Mannitol 20%
15 A Comparative Study Between Laryngeal Mask Airway and Magensium Sulphate in Attenuating Systemic Stress Response During Emergence of Patients Undergoing Supratentorial Tumours. Completed NCT03406403 Magensium sulphate
16 The Usefulness of the Combination of Preoperative Assessment of Optic Nerve Sheath Diameter and Heart Rate Variability to Predict Intraoperative Brain Condition in Patients With Supratentorial Tumors Completed NCT04094974
17 Brain Relaxation Facilitated by Mannitol in Craniotomy: Insight Into the Optimized Operation Window Completed NCT03444519 Mannitol
18 The Effect of Intraoperative Variations in Positive-End Expiratory Pressure on Subdural Pressure, Optic Nerve Sheath Diameter, Lung Compliance and Brain Perfusion Pressure in Supratentorial Tumor Surgery Recruiting NCT04316208
19 Comparison of Desflurane and Propofol for Brain Relaxation in Patients Undergoing Supratentorial Craniotomy:a Randomized Controlled Study Recruiting NCT04691128 Desflurane;Propofol
20 A Prospective, Self-paired, Single-center Clinical Trial Evaluating the Accuracy of Brain Biological Electrical Impedance Tomography Screen for Supratentorial Tumors Active, not recruiting NCT04490954
21 Pre- vs. Postoperative Scalp Block for Pain Control After Supratentorial Craniotomy Not yet recruiting NCT04344132
22 Comparison of Continuous Infusion of 3% Hypertonic Saline, Bolus of 3% Hypertonic Saline and Mannitol on Brain Relaxation During Supratentorial Tumor Resection: A Prospective, Randomized, Clinical Study Not yet recruiting NCT04314674 %3 HS bolus;%3 HS infusion 20 ml/h;20% mannitol

Search NIH Clinical Center for Supratentorial Cancer

Cochrane evidence based reviews: supratentorial neoplasms

Genetic Tests for Supratentorial Cancer

Anatomical Context for Supratentorial Cancer

MalaCards organs/tissues related to Supratentorial Cancer:

40
Brain, Eye, Pineal

Publications for Supratentorial Cancer

Articles related to Supratentorial Cancer:

(show all 26)
# Title Authors PMID Year
1
Perioperative Management of Pediatric Giant Supratentorial Tumors: Challenges and Management Strategies. 61
31908662 2019
2
Dural-Based Frontal Lobe Hemangioblastoma. 61
31150863 2019
3
Undiagnosed obstructive sleep apnea as a predictor of 30-day readmission for brain tumor patients. 61
31323636 2019
4
Mediobasal and lateral temporal gliomas exhibit different growth patterns, surgical outcomes and prognoses. 61
25867451 2015
5
[Germ cell and embryonal tumors]. 61
25119569 2014
6
Intraoperative electrocorticography-guided microsurgical management for patients with onset of supratentorial neoplasms manifesting as epilepsy: a review of 65 cases. 61
24866815 2014
7
Effect of intraoperative glucose fluctuation and postoperative IL-6, TNF-α, CRP levels on the short-term prognosis of patients with intracranial supratentorial neoplasms. 61
25605194 2014
8
Emergence times are similar with sevoflurane and total intravenous anesthesia: results of a multicenter RCT of patients scheduled for elective supratentorial craniotomy. 61
20308817 2010
9
Expression of p53, EGFR, pRb and bcl-2 proteins in pediatric glioblastoma multiforme: a study of 54 patients. 61
16293948 2005
10
Supratentorial low-grade gliomas. Neuroradiology. 61
16288189 2005
11
Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist. 61
15047924 2004
12
Cerebral neoplasms in adults. 61
10231906 1999
13
Expression of oncoprotein Bcl-2 and bax protein in the infiltration zone and in the parenchyma of primary glia-derived supratentorial neoplasms. 61
10323081 1998
14
Desmoplastic supratentorial neuroepithelial tumours of childhood: imaging in 5 patients. 61
8811706 1996
15
Peri-operative prophylaxis with phenytoin: dosage and therapeutic plasma levels. 61
8861695 1996
16
Computed tomography and magnetic resonance imaging findings in primitive neuroectodermal tumours in adults. 61
8785615 1996
17
Thallium-201-SPECT and 99Tc-HM-PAO SPECT imaging to study functionally cerebral supratentorial neoplasms: the biological basis of the functional imaging interpretation. 61
8803843 1995
18
[Early epilepsy in surgery of extra-axial supratentorial neoplasms]. 61
1620438 1992
19
Intracranial ependymomas in children. 61
2357709 1990
20
Adult supratentorial tumors. 61
2190324 1990
21
[Retrospective analysis of the incidence of midline supratentorial neoplasms in children and young patients: craniopharyngiomas, hypophyseal and pineal neoplasms]. 61
2259823 1990
22
Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours. 61
2360466 1990
23
Supratentorial neoplasms, including the sella and parasellar region. 61
2624769 1989
24
Intracranial neoplasms in children in Ibadan, Nigeria. 61
3857124 1985
25
Specificity of computed tomography in the diagnosis of supratentorial neoplasms. Consideration of metastases and meningiomas. 61
745752 1978
26
Carotid angiography in the localisation of supratentorial neoplasms and hamartomata. 61
13624051 1959

Variations for Supratentorial Cancer

Expression for Supratentorial Cancer

Search GEO for disease gene expression data for Supratentorial Cancer.

Pathways for Supratentorial Cancer

Pathways related to Supratentorial Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.78 TP53 SHH RELA EGFR
2 11.63 SYP RBFOX3 NF2 MYCN GFAP ENO2
3 11.28 TP53 IDH1 EGFR
4 11.15 SYP SHH OLIG2 GFAP

GO Terms for Supratentorial Cancer

Biological processes related to Supratentorial Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 YAP1 TP53 SMARCB1 SHH RELA MYCN
2 regulation of cell proliferation GO:0042127 9.73 YAP1 TP53 SHH NF2
3 thalamus development GO:0021794 9.51 SHH OLIG2
4 hair follicle development GO:0001942 9.5 SHH RELA EGFR
5 positive regulation of transcription, DNA-templated GO:0045893 9.5 YAP1 TP53 TAF12 SHH RELA MYCN
6 ectoderm development GO:0007398 9.49 SHH NF2
7 regulation of protein localization to nucleus GO:1900180 9.48 SHH NF2
8 Bergmann glial cell differentiation GO:0060020 9.46 SHH GFAP
9 regulation of stem cell proliferation GO:0072091 9.37 YAP1 NF2
10 negative regulation of protein catabolic process GO:0042177 9.33 SHH RELA EGFR
11 response to cobalamin GO:0033590 9.26 RELA EGFR
12 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.8 TP53 MYCN EGFR

Sources for Supratentorial Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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