Aliases & Classifications for Sutton Disease 2

MalaCards integrated aliases for Sutton Disease 2:

Name: Sutton Disease 2 53 73
Recurrent Aphthous Stomatitis 29 6
Aphthous Stomatitis, Recurrent 53
Recurrent Scarring Aphthae 53
Aphthous Ulcer, Recurrent 53
Recurrent Aphthous Ulcer 73
Major Aphthous Ulcer 53
Major Canker Sore 53

Classifications:



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Summaries for Sutton Disease 2

NIH Rare Diseases : 53 Sutton disease 2, also known as recurrent aphthous stomatitis, is a chronic inflammatory disease characterized by painful ulcers in the mouth. These sores, which can be of varying size and frequency, are commonly called canker sores. The exact cause of this condition is not fully understood, although it may be due to an abnormal immune response. Treatment is not always necessary, but may include mouth rinses, topical ointments or systemic corticosteroids.

MalaCards based summary : Sutton Disease 2, also known as recurrent aphthous stomatitis, is related to aphthous stomatitis and stomatitis. An important gene associated with Sutton Disease 2 is VPS13B (Vacuolar Protein Sorting 13 Homolog B). The drugs Minocycline and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, testes and thyroid.

Related Diseases for Sutton Disease 2

Diseases related to Sutton Disease 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 aphthous stomatitis 10.6
2 stomatitis 10.5

Symptoms & Phenotypes for Sutton Disease 2

Drugs & Therapeutics for Sutton Disease 2

Drugs for Sutton Disease 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Early Phase 1 50-02-2 5743
3
Menthol Approved Phase 3 2216-51-5 16666
4
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
5
Glycerol Approved, Investigational Phase 3 56-81-5 753
6
Hydroxocobalamin Approved Phase 3,Not Applicable 13422-51-0 11953898 44475014
7
Ethanol Approved Phase 3 64-17-5 702
8
Neomycin Approved, Vet_approved Phase 3 1404-04-2 8378
9
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
10
Cyanocobalamin Approved, Nutraceutical Phase 3,Not Applicable 68-19-9 44176380
11 Dexamethasone acetate Phase 3,Early Phase 1 1177-87-3
12 glucocorticoids Phase 3,Phase 2
13
protease inhibitors Phase 3
14 Gastrointestinal Agents Phase 3,Phase 2,Early Phase 1
15 HIV Protease Inhibitors Phase 3
16 Hormone Antagonists Phase 3,Phase 2
17 Hormones Phase 3,Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
19 Peripheral Nervous System Agents Phase 3,Phase 2,Early Phase 1
20 Anti-Bacterial Agents Phase 3
21 Anti-Infective Agents Phase 3
22 Antiemetics Phase 3,Phase 2,Early Phase 1
23 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
24 BB 1101 Phase 3,Early Phase 1
25 Autonomic Agents Phase 3,Phase 2,Early Phase 1
26 Antineoplastic Agents, Hormonal Phase 3
27
Bismuth Phase 3 7440-69-9 16682734 105143
28 Central Nervous System Depressants Phase 3,Phase 2,Early Phase 1
29 Retinol palmitate Phase 3
30 Micronutrients Phase 3,Phase 2,Not Applicable
31 Anesthetics Phase 3,Phase 2,Early Phase 1
32 Trace Elements Phase 3,Phase 2,Not Applicable
33 Anesthetics, Local Phase 3,Phase 2,Early Phase 1
34 Antacids Phase 3
35 Vitamin B 12 Phase 3,Not Applicable
36 Vitamins Phase 3,Not Applicable
37 Anti-Ulcer Agents Phase 3
38 Vitamin B12 Nutraceutical Phase 3,Not Applicable
39
Cobalamin Nutraceutical Phase 3,Not Applicable 13408-78-1 6438156
40 retinol Nutraceutical Phase 3
41
Zinc Approved, Investigational Phase 2,Early Phase 1 7440-66-6 23994
42
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
43
Ibuprofen Approved Phase 2 15687-27-1 3672
44
Diphenhydramine Approved, Investigational Phase 2,Early Phase 1 147-24-0, 58-73-1 3100
45
Histamine Approved, Investigational Phase 2,Early Phase 1 75614-87-8, 51-45-6 774
46
Betamethasone Approved, Vet_approved Phase 2 378-44-9 9782
47
Promethazine Approved, Investigational Phase 2,Early Phase 1 60-87-7 4927
48
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
49
Zinc sulfate Approved, Investigational Phase 2 7733-02-0
50 Prednisolone acetate Phase 2

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
2 Prevention of Recurrent Aphthous Stomatitis Using Vitamins Completed NCT00527306 Phase 3
3 Efficacy of the Combination Bismuth + Neomycin + Procaine in the Treatment of Recurrent Aphthous Ulceration Completed NCT00857688 Phase 3 Bismu-Jet
4 Omega-3 and Quality of Life in Recurrent Aphthous Stomatitis Patients Unknown status NCT01831453 Phase 2 omega-3;placebo
5 Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis Completed NCT01652625 Phase 2 Yunnan Baiyao toothpaste;Placebo toothpaste
6 Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study Completed NCT01210014 Phase 2 zinc sulphate 220mg/day in one dosage;placebo: one dosage
7 Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis Completed NCT01293968 Phase 2 Ibuprofen, Diphenhydramine and Aluminium MgS;Diphenhydramine and Aluminium MgS
8 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
9 Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome Recruiting NCT03469232 Phase 1, Phase 2 Huanglian-Jiedu Decoction
10 Effectiveness and Safety of Lactobacillus Rhamnosus Lcr35® in the Treatment of Recurrent Aphthous Stomatitis Recruiting NCT02789605 Phase 2 Bacilor;Placebo
11 Efficacy of Adhesive Tablets in Treating Oral Ulcers (Aphthous) Suspended NCT00281723 Phase 2 Pro-Pe adhesive tablet
12 Clinical Evaluation of Fluid Extract of Chamomilla Tincture for Oral Aphthae Completed NCT01122147 Phase 1 chamomilla tincture mouthwash;placebo mouthwash
13 Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis Completed NCT01501409 Not Applicable
14 Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis Completed NCT00288769 Not Applicable daily sublingual tablets Vitamin B12 1000 mcg versus placebo
15 Treatment of Recurrent Aphthous Stomatitis With Er,Cr:YSGG Laser Irradiation Completed NCT02925182 Not Applicable
16 The Effect of 2-DeNT Oral Topical Powder on Minor Recurrent Aphthous Ulcer Completed NCT02142543 Early Phase 1 2-DeNT powder;Placebo Comparator
17 A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis Completed NCT00315679 Not Applicable Pentoxifylline (also known as oxpentifylline)
18 Special Investigation in Patients With Intestinal Behcet's Disease (All Case Investigation) Completed NCT01960790
19 The Salivary and Faecal Microbiome of Recurrent Aphthous Stomatitis Patients Before and After Treatment With Probiotics Recruiting NCT02976922 Not Applicable
20 Tokushima Night Guard for Recurrent Aphthous Stomatitis Recruiting NCT02890524 Early Phase 1
21 Oral Lesions In Non-Celiac Wheat Sensitivity Patients Recruiting NCT02421809
22 The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus Not yet recruiting NCT03052179 Not Applicable
23 Clinical Evaluation of Topical Coenzyme Q10 in Management of Oral Aphthous Ulcer Not yet recruiting NCT03213769 Not Applicable topical coenzyme Q10 gel;Carpabol gel
24 Influence of Different Doses of the Vitamin B12 on Recurrent Aphthous Stomatitis Terminated NCT01127724 Not Applicable vitamin B12 treatment

Search NIH Clinical Center for Sutton Disease 2

Genetic Tests for Sutton Disease 2

Genetic tests related to Sutton Disease 2:

# Genetic test Affiliating Genes
1 Recurrent Aphthous Stomatitis 29

Anatomical Context for Sutton Disease 2

MalaCards organs/tissues related to Sutton Disease 2:

41
Neutrophil, Testes, Thyroid, T Cells, Heart, Endothelial

Publications for Sutton Disease 2

Articles related to Sutton Disease 2:

(show top 50) (show all 450)
# Title Authors Year
1
Association of Serotonin Transporter Gene Polymorphism with Recurrent Aphthous Stomatitis. ( 29296268 )
2018
2
Prevalence and psychological stress in recurrent aphthous stomatitis among female dental students in Saudi Arabia. ( 29785161 )
2018
3
The association between minor recurrent aphthous stomatitis (RAS), children's poor oral condition, and underlying negativeA psychosocial habits and attitudes towards oral hygiene. ( 29653566 )
2018
4
Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus. ( 29753458 )
2018
5
Autosomal dominant deficiency of the interleukin-17F in recurrent aphthous stomatitis: Possible novel mutation in a new entity. ( 29458167 )
2018
6
Associations of IL-1, 6, and 10 Gene Polymorphisms with Susceptibility to Recurrent Aphthous Stomatitis: Insights from a Meta-Analysis. ( 29641282 )
2018
7
Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk. ( 29550839 )
2018
8
Association of the nod-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population. ( 29430721 )
2018
9
Healthy lifestyle habits benefit remission of recurrent aphthous stomatitis and RAS type ulceration. ( 29327722 )
2018
10
Hematinic dei-8ciencies in patients with recurrent aphthous stomatitis: variations by gender and age. ( 29476670 )
2018
11
Salivary levels of TNF-I+ in patients with recurrent aphthous stomatitis: A cross-sectional study. ( 29732020 )
2018
12
Relationship between salivary calprotectin levels and recurrent aphthous stomatitis: A preliminary study. ( 29519972 )
2018
13
Examination of serum hematinics and autoantibodies is important for treatment of recurrent aphthous stomatitis. ( 29336939 )
2018
14
Analysis of Dietary Related Factors of Recurrent Aphthous Stomatitis among College Students. ( 29681971 )
2018
15
Haematinic deficiencies and patient clinical profiles in Polish patients with recurrent aphthous stomatitis (RAS). ( 29499093 )
2018
16
The association between interleukin polymorphism and recurrent aphthous stomatitis: A meta-analysis. ( 29800802 )
2018
17
Evidence that Enterobius vermicularis plays a causative role for PFAPA and recurrent aphthous stomatitis. ( 29856193 )
2018
18
Evaluation and Comparison of Total Antioxidant Capacity of Saliva Between Patients with Recurrent Aphthous Stomatitis and Healthy Subjects. ( 29755602 )
2018
19
A Clinical and Microbiological Evaluation of Helicobacter pylori in Recurrent Aphthous Stomatitis. ( 29208798 )
2017
20
Preventive effects of mouthguard use while sleeping on recurrent aphthous stomatitis: Preliminary interventional study. ( 29744201 )
2017
21
Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS). ( 29262804 )
2017
22
Interleukin-2, Interferon-gamma Gene Polymorphisms in Recurrent Aphthous Stomatitis. ( 28922104 )
2017
23
Letter regarding "Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review". ( 28801870 )
2017
24
Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis. ( 27793414 )
2017
25
Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic. ( 28776757 )
2017
26
Recurrent aphthous stomatitis in 18-year-old adolescents - Prevalence and associated factors: a population-based study. ( 29166496 )
2017
27
Association of IL-6-174a88G/C and IL10-1082a88G/A polymorphisms with recurrent aphthous stomatitis risk: A meta-analysis. ( 29384969 )
2017
28
The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oralA rinse. ( 28411006 )
2017
29
Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis. ( 28839413 )
2017
30
The absence of an association between Interleukin 1I^ gene polymorphisms and recurrent aphthous stomatitis (RAS). ( 28942153 )
2017
31
Systemic bioinformatics analysis of recurrent aphthous stomatitis gene expression profiles. ( 29340037 )
2017
32
Vitamin D status in recurrent aphthous stomatitis. ( 29422828 )
2017
33
Assessment of Oxidant-Antioxidant Status and Stress Factor in Recurrent Aphthous Stomatitis Patients: Case Control Study. ( 28511497 )
2017
34
Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis. ( 27875792 )
2017
35
Patient-reported outcome measures in recurrent aphthous stomatitis: A critical assessment of quality properties. ( 28779517 )
2017
36
Association of Transforming Growth Factor-Beta Gene Polymorphisms in Recurrent Aphthous Stomatitis. ( 29307155 )
2017
37
Efficacy and safety of Chinese patent medicines in the treatment ofA recurrent aphthous stomatitis: A systematic review. ( 28062049 )
2017
38
Recurrent Aphthous Stomatitis: A Review. ( 28360966 )
2017
39
INFLUENCE OF OZONE THERAPY ON ORAL TISSUE IN MODELING OF CHRONIC RECURRENT APHTHOUS STOMATITIS. ( 28480862 )
2017
40
Salivary Alpha-Amylase Enzyme, Psychological Disorders, and Life Quality in Patients with Recurrent Aphthous Stomatitis. ( 28408928 )
2017
41
Enzymatic antioxidants status in patients with recurrent aphthous stomatitis. ( 28054386 )
2017
42
Recurrent Aphthous Stomatitis: An Assessment of Antioxidant Levels in Plasma and Saliva. ( 29207836 )
2017
43
Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis. ( 28543912 )
2017
44
Stress as a Cause of Recurrent Aphthous Stomatitis and Its Correlation with Salivary Stress Markers. ( 28847142 )
2017
45
Is there a role of food additives in recurrent aphthous stomatitis? A prospective study with patch testing. ( 28035659 )
2016
46
Is Optimal Management of Recurrent Aphthous Stomatitis Possible? A Reality Check. ( 27891490 )
2016
47
The safety and efficacy of AphtoFixAr mouth ulcer cream in the management of recurrent aphthous stomatitis. ( 26868504 )
2016
48
Lack of Association between Interleukin-12 Gene Polymorphisms and Recurrent Aphthous Stomatitis. ( 27920889 )
2016
49
Status of Neutrophils, Lymphocytes and Platelets in Patients with Recurrent Aphthous Stomatitis: A Retrospective Study. ( 28008393 )
2016
50
Different modalities for treatment of recurrent aphthous stomatitis. A Randomized clinical trial. ( 27957263 )
2016

Variations for Sutton Disease 2

ClinVar genetic disease variations for Sutton Disease 2:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 VPS13B NM_017890.4(VPS13B): c.11314C> T (p.Gln3772Ter) single nucleotide variant Pathogenic rs386834061 GRCh37 Chromosome 8, 100880540: 100880540
2 VPS13B NM_017890.4(VPS13B): c.11314C> T (p.Gln3772Ter) single nucleotide variant Pathogenic rs386834061 GRCh38 Chromosome 8, 99868312: 99868312
3 VPS13B NM_017890.4(VPS13B): c.4620delA (p.Ser1541Profs) deletion Pathogenic rs1057518939 GRCh37 Chromosome 8, 100523652: 100523652
4 VPS13B NM_017890.4(VPS13B): c.4620delA (p.Ser1541Profs) deletion Pathogenic rs1057518939 GRCh38 Chromosome 8, 99511424: 99511424

Expression for Sutton Disease 2

Search GEO for disease gene expression data for Sutton Disease 2.

Pathways for Sutton Disease 2

GO Terms for Sutton Disease 2

Sources for Sutton Disease 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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