MCID: SWY001
MIFTS: 23

Swayback

Categories: Metabolic diseases

Aliases & Classifications for Swayback

MalaCards integrated aliases for Swayback:

Name: Swayback 12 44 15 73
Swayback of Sheep 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5112
MeSH 44 D013540
SNOMED-CT 68 78714004
UMLS 73 C0038981

Summaries for Swayback

MalaCards based summary : Swayback, also known as swayback of sheep, is related to multiple sclerosis and menkes disease. An important gene associated with Swayback is CNPY3 (Canopy FGF Signaling Regulator 3). The drugs Alvimopan and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and liver, and related phenotype is hematopoietic system.

Wikipedia : 76 Swayback refers to abnormal bent-back postures in humans and in quadrupeds, especially horses.It can... more...

Related Diseases for Swayback

Diseases related to Swayback via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 10.2
2 menkes disease 10.0
3 demyelinating disease 10.0
4 encephalitis 10.0
5 lig4 syndrome 10.0 ATM COX5A
6 iron metabolism disease 9.9 CP HFE
7 hemosiderosis 9.9 CP HFE
8 metal metabolism disorder 9.8 CP HFE
9 atransferrinemia 9.8 CP HFE
10 wilson disease 9.8 CP HFE
11 deficiency anemia 9.8 CP HFE
12 hemochromatosis, type 1 9.7 CP HFE
13 aceruloplasminemia 9.7 ATM CP HFE

Graphical network of the top 20 diseases related to Swayback:



Diseases related to Swayback

Symptoms & Phenotypes for Swayback

MGI Mouse Phenotypes related to Swayback:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.02 ATM CNPY3 CP HFE RUNX2

Drugs & Therapeutics for Swayback

Drugs for Swayback (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alvimopan Approved, Investigational Phase 4 156053-89-3 5488548
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
5 Gastrointestinal Agents Phase 4
6 Betamethasone sodium phosphate Phase 4
7 Betamethasone-17,21-dipropionate Phase 4
8
protease inhibitors Phase 4
9 Betamethasone Valerate Phase 4 2152-44-5
10 Antiemetics Phase 4
11 Antineoplastic Agents, Hormonal Phase 4
12 Hormones Phase 4,Phase 2,Phase 3
13 Autonomic Agents Phase 4
14 Anti-Inflammatory Agents Phase 4,Phase 3
15 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
16 Respiratory System Agents Phase 4
17 Betamethasone benzoate Phase 4
18 BB 1101 Phase 4
19 Hormone Antagonists Phase 4,Phase 2,Phase 3
20 HIV Protease Inhibitors Phase 4
21 Anti-Asthmatic Agents Phase 4
22 glucocorticoids Phase 4
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
24 Calcium, Dietary Phase 4,Phase 3
25
Fospropofol Approved, Illicit, Investigational Phase 3 258516-87-9, 258516-89-1 3038497
26
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
27
Progesterone Approved, Vet_approved Phase 2, Phase 3 57-83-0 5994
28
Diclofenac Approved, Vet_approved Phase 3 15307-86-5 3033
29
Ketorolac Approved Phase 3 66635-83-4, 74103-06-3 3826
30
Oxymorphone Approved, Investigational, Vet_approved Phase 3 76-41-5 5284604
31
Nitroglycerin Approved, Investigational Phase 3 55-63-0 4510
32
Clevidipine Approved, Investigational Phase 3 167221-71-8
33 Anesthetics, Intravenous Phase 3
34 Central Nervous System Depressants Phase 3,Phase 2,Not Applicable
35 Hypnotics and Sedatives Phase 3
36 Anesthetics Phase 3,Phase 2,Not Applicable
37 Anesthetics, General Phase 3
38 Caproate Phase 2, Phase 3
39 11-hydroxyprogesterone Phase 2, Phase 3
40 17-alpha-hydroxy-progesterone caproate Phase 2, Phase 3
41 Progestins Phase 2, Phase 3
42 Estrogen Antagonists Phase 2, Phase 3
43 Estrogens Phase 2, Phase 3
44 Estrogen Receptor Antagonists Phase 2, Phase 3
45 Ketorolac Tromethamine Phase 3
46 Antirheumatic Agents Phase 3
47 Analgesics, Non-Narcotic Phase 3
48 Anti-Inflammatory Agents, Non-Steroidal Phase 3
49 Cyclooxygenase Inhibitors Phase 3
50 Analgesics Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 93)
# Name Status NCT ID Phase Drugs
1 Proximal Junctional Kyphosis Following Long Instrumented Spinal Fusion: The Effect of Implant Selection Completed NCT01441999 Phase 4
2 Study on the Treatment of Osteoporotic Vertebral Fractures Using Vertebral Body Stenting Completed NCT01847898 Phase 4
3 A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy Completed NCT00708201 Phase 4 Alvimopan;Placebo
4 A Randomized Trial Comparing the Impact of One Versus Two Courses of Antenatal Steroids (ACS) on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
5 Comparison of Actifuse ABX and Local Bone in Spinal Surgery Terminated NCT01852747 Phase 4
6 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
7 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
8 An Effectiveness and Safety Study of AQUAVAN® Injection (Fospropofol Disodium) for Sedation During Flexible Bronchoscopy Completed NCT00306722 Phase 3 AQUAVAN® (fospropofol disodium) Injection
9 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
10 Efficacy and Safety of IV Diclofenac (DIC075V) for Pain After Abdominal or Pelvic Surgery Completed NCT00448110 Phase 3 Intravenous Diclofenac (DIC075V);Intravenous Ketorolac;placebo
11 Efficacy and Safety of Oxymorphone Immediate Release in Post-surgical Acute Pain Completed NCT00226395 Phase 3 Oxymorphone immediate release
12 Clevidipine in the Perioperative Treatment of Hypertension (ECLIPSE-NTG) Completed NCT00093886 Phase 3 clevidipine;nitroglycerin
13 Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass (PRIMO-CABG II) Completed NCT00088179 Phase 3 pexelizumab in conjunction with CABG
14 Safety and Efficacy Study of 4975 in Patients Undergoing Total Knee Replacement Completed NCT00681356 Phase 3 4975, 15 and 5 mg;Placebo Comparator;4975 - 5 mg
15 Surgical Treatment of Spinal Deformity With Sagittal Imbalance Using Patient-specific Rods: A Multicenter, Controlled, Double- Blind Randomized Trial: The PROFILE Study Not yet recruiting NCT02730507 Phase 3
16 A Study of the Safety, Tolerability & Efficacy of Long-term Administration of Drisapersen in US & Canadian Subjects Terminated NCT01803412 Phase 3 Drisapersen;Drisapersen;Drisapersen
17 Efficacy and Safety Evaluation of Recombinant Human Growth Hormone (r-hGH), Saizen®, on a Population of Children With Hypochondroplasia, Treated at Least 3 Years or Until Near Final Height, When Applicable, in Comparison With a Historic Cohort of Non-treated Children Completed NCT01111019 Phase 2 Recombinant human growth hormone (Somatropin)
18 Dose-ranging Study for Postoperative Analgesia in Subjects Undergoing Primary Unilateral Inguinal Hernia Repair Completed NCT00485433 Phase 2 Bupivacaine HCl;SKY0402
19 Study to Evaluate Analgesic Effect of Intravenous Administration of Kappa Agonist CR845 After Hysterectomy Surgery Completed NCT00877799 Phase 2 CR845;CR845;CR845;Placebo;Placebo
20 CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB) Terminated NCT00107666 Phase 2 CTI-01 (ethyl pyruvate)
21 Could Cervical Postural Changes Affect the Long Thoracic Nerve Electromyographic Findings? Unknown status NCT02639104 Not Applicable
22 Hammock Positioning's Influence on the Electromyographic Activity in the Flexor Muscles in Newborn Preterm Unknown status NCT02621996 Not Applicable
23 InterFuse® S and T for the Treatment of Scoliosis, Spondylolisthesis and Degenerative Disc Disease (DDD) Unknown status NCT02659722
24 Impact of Age on Surgical Outcome of Adolescent Idiopathic Scoliosis Unknown status NCT02819245 Not Applicable
25 Efficacy and Influence of Pilates Based Physical Therapy Exercises for Low Back Pain Unknown status NCT02622789
26 Dynamic Cervical Change: Prediction of Preterm Labor in Symptomatic Patients Unknown status NCT00298480
27 Post-market Surveillance Study of FLXfit™ TLIF Interbody Fusion Device Unknown status NCT02805985 Not Applicable
28 Analyze the Relationship Between the Density of Fat Tissue and Cellulite With the Lumbar Lordosis Degree Completed NCT02903459
29 Trunk Position Sense, Postural Stability and Spinal Posture in Fibromyalgia Completed NCT03757702
30 SPONGIT: Comparison of Two Surgical Approaches in the Treatment of Degenerative Spondylolysthesis Completed NCT00869882 Not Applicable
31 The Influence of High Heeled Shoes on the Sagittal Balance of the Spine and Whole Body Completed NCT02254694 Not Applicable
32 Effectiveness of Functional Pillow on Neck Pain, Disability, Quality of Sleep and Life Completed NCT02240849 Not Applicable
33 Effects of Unstable Shoes on Trunk Muscle Activity, Lumbar Spine Kinematics and Pain in Patients With Low Back Pain Completed NCT02606370 Not Applicable
34 Comparison of Cage Versus Plate in One Level Cervical Disc Disease Completed NCT01011569
35 Multicenter Retrospective Evaluation of the Surgical Management of Spinal Growth Dystrophy Completed NCT02904681
36 Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine Surgery Completed NCT00320619 Not Applicable Epsilon-Aminocaproic Acid (EACA);Placebo
37 The Frequency Forward Head Posture in Subjects With Temporomandibular Disorder Completed NCT00743223
38 Comparison of Successful Spinal Needle Placement Between Crossed Leg Sitting Position and Traditional Sitting Position Completed NCT02766829 Not Applicable
39 Effects of a School-based Exercise Program on Posture, Trunk Range of Motion, and Musculoskeletal Pain Completed NCT02255695 Not Applicable
40 Fluoroscopy Guided Lumbar Facet Joint Injection Versus Ultrasound Guided Injection in Patients With Low Back Pain Due to Facet Syndrome Completed NCT03770585 Not Applicable
41 The Effect of Myofascial Release in Patients With Cervicogenic Headache Completed NCT03113357 Not Applicable
42 Spine Reference Parameters on EOS Imaging Completed NCT01406743
43 Adolescent Idiopathic Scoliosis (AIS) Patient Positioning in EOS System® Completed NCT02269657
44 Post Market Surveillance to Evaluate the Effectiveness the Polaris Deformity Spinal System Completed NCT01220505
45 Postural Balance of the Adult Completed NCT00926432 Not Applicable
46 Prediction of 3D Effect of Brace in Idiopathic Scoliosis Treatment Using EOS Imaging System and "Anatomic Transfer". Completed NCT03209752
47 the Evaluation of Four Non-operative Treatments for Degenerative Lumbar Spinal Stenosis Completed NCT02592642 Not Applicable
48 A Study Comparing Fusion Rates of Two Lumbar Fusion Procedures Completed NCT01972256
49 Optimal Management of Vasa Previa Study - A Retrospective Study Completed NCT01977040
50 Neonatal Outcome by Reason for Delivery Completed NCT01818518

Search NIH Clinical Center for Swayback

Cochrane evidence based reviews: swayback

Genetic Tests for Swayback

Anatomical Context for Swayback

MalaCards organs/tissues related to Swayback:

41
Spinal Cord, Brain, Liver

Publications for Swayback

Articles related to Swayback:

(show top 50) (show all 59)
# Title Authors Year
1
Delayed swayback diagnosed in lambs with hindlimb paresis. ( 25634923 )
2015
2
Genetics of swayback in American Saddlebred horses. ( 21070278 )
2010
3
Copper deficiency myelopathy (human swayback). ( 17036563 )
2006
4
Human swayback disease: expanding the spectrum of diseases associated with abnormal copper metabolism. ( 11569902 )
2001
5
Cytochrome-c oxidase isolated from the brain of swayback-diseased sheep displays unusual structure and uncharacteristic kinetics. ( 10327420 )
1998
6
Swayback warning. ( 9571759 )
1998
7
Novel mitochondrial proteins and decreased intrinsic activity of cytochrome-c oxidase. Characteristics of swayback disease in sheep. ( 8871971 )
1996
8
Swayback in a blesbok (Damaliscus dorcas phillipsi) and a black wildebeest (Connochaetes gnou). ( 8765071 )
1996
9
Delayed swayback in goat kids, a study of 23 cases. ( 3515745 )
1986
10
A farm investigation into swayback in a herd of goats and the result of administration of copper needles. ( 3526699 )
1986
11
Swayback and copper supplementation. ( 4060531 )
1985
12
Multiple sclerosis in research workers studying swayback in lambs: an updated report. ( 4045479 )
1985
13
Menkes' disease and swayback. A comparative study of two copper deficiency syndromes. ( 6668480 )
1983
14
Cupric oxide needles in the prevention of swayback. ( 7101715 )
1982
15
Enzootic ataxia (swayback) in goats. ( 17422116 )
1982
16
Studies on viral leukoencephalomyelitis and swayback in goats. ( 7193109 )
1980
17
California goats with a disease resembling enzootic ataxia or swayback. ( 566481 )
1978
18
Multiple sclerosis and the swayback story. ( 46064 )
1975
19
A neurochemical study of field cases of the delayed spinal form of swayback (enzootic ataxia) in lambs. ( 4452905 )
1974
20
Swayback (enzootic ataxia) in Alberta lambs. ( 4274817 )
1974
21
Observations on the pathogenesis of delayed swayback. ( 4450391 )
1974
22
Congenital and delayed swayback in lambs in Northern Ireland. ( 5073594 )
1972
23
Relationships between swayback incidence and concentration of copper in the blood of sheep of different breeds. ( 5167497 )
1971
24
Deaths in ewes following the administration of copper calcium edetate for prevention of swayback. ( 4979405 )
1969
25
Structural changes of the central nervous system in swayback (Enzootic Ataxia) of lambs. V. Electron microscopic observations of the corpus callosum. ( 5817344 )
1969
26
Effect of intake of copper, molybdenum and sulphate on copper metabolism in sheep. IV. Production of congenital and delayed swayback. ( 4310872 )
1969
27
Copper concentrations in the liver and blood of sheep of different breeds in relation to swayback history. ( 5813286 )
1969
28
Structural changes of the central nervous system in swayback (enzootic ataxia) of lambs. IV. Electron microscopy of the white matter of the spinal cord. ( 5751529 )
1968
29
Observations on the histology and possible pathogenesis of lesions in the central nervous system of sheep with swayback. ( 5748757 )
1968
30
Observations on the lesions in the white matter of the spinal cord of swayback sheep. ( 5751326 )
1968
31
Cardiovascular system in naturally occurring copper deficiency and swayback in sheep. ( 4226954 )
1967
32
A comparison of the composition of white matter lipids in swayback and border disease of lambs. ( 5950126 )
1966
33
Genetic and other factors in the occurrence of swayback in sheep. ( 6008381 )
1966
34
Cerebral oedema in lambs associated with hypocuprosis, and its relationship to swayback. II. Histopathological findings. ( 6007465 )
1966
35
Structural changes of central nervous system in swayback (enzootic ataxia) of lambs. 3. Electron microscopy of the cerebral lesions. ( 6006979 )
1966
36
Blood copper-levels in sheep in relation to genetic factors, parity and previous swayback history. ( 5950873 )
1966
37
Structural changes of the central nervous system in swayback (enzootic ataxia) of lambs. II. Electron microscopy of the lower motor neuron. ( 6006978 )
1966
38
Cerebral oedema in lambs associated with hypocuprosis, and its relationship to swayback. I. Field, clinical, gross anatomical and biochemical observations. ( 6007464 )
1966
39
ADMINISTRATION OF COPPER TO LAMBS FOR PREVENTION OF DELAYED SWAYBACK: POSSIBLE TOXIC EFFECTS. ( 14331453 )
1965
40
Minerals and the ruminant with special reference to the discovery of swayback in the goat. ( 4287633 )
1965
41
Pathological and biochemical studies of an outbreak of swayback in goats. ( 5892661 )
1965
42
COPPER DEFICIENCY IN RELATION TO SWAYBACK IN SHEEP. II. EFFECT OF DOSING YOUNG LAMBS WITH MOLYBDATE AND SULPHATE. ( 14212102 )
1964
43
MEASUREMENT OF NERVE CELL DAMAGE IN THE SPINAL CORD OF LAMBS AFFECTED WITH SWAYBACK. ( 14212113 )
1964
44
Copper deficiency in relation to swayback in sheep. I. Effect of molybdate and sulphate supplements during pregnancy. ( 14017364 )
1963
45
Further observations on swayback. II. Histochemical localisation of cytochrome oxidase activity in the central nervous system. ( 13966718 )
1963
46
Further observations on swayback. I. Transitional pathology. ( 13966717 )
1963
47
Factors influencing the blood and plasma copper levels of sheep in swayback flocks. ( 14017365 )
1963
48
Swayback in south-east Scotland. II. Clinical, pathological and biochemical aspects. ( 13687057 )
1960
49
Swayback in south-east Scotland. I. Field aspects. ( 13687056 )
1960
50
The copper content and cytochrome oxidase activity of tissues from normal and swayback lambs. ( 13662311 )
1959

Variations for Swayback

Expression for Swayback

Search GEO for disease gene expression data for Swayback.

Pathways for Swayback

GO Terms for Swayback

Biological processes related to Swayback according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 BMP signaling pathway GO:0030509 9.16 HFE RUNX2
2 positive regulation of gene expression GO:0010628 9.13 ATM HFE RUNX2
3 cellular iron ion homeostasis GO:0006879 8.62 CP HFE

Sources for Swayback

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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