MCID: SWT008
MIFTS: 32

Sweat Gland Benign Neoplasm

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sweat Gland Benign Neoplasm

MalaCards integrated aliases for Sweat Gland Benign Neoplasm:

Name: Sweat Gland Benign Neoplasm 12
Sweat Gland Neoplasm 15 17
Tumor of the Sweat Gland 12
Neoplasm of Sweat Gland 12
Sweat Gland Neoplasms 43
Sweat Gland Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2664
MeSH 43 D013544
NCIt 49 C3398
SNOMED-CT 67 126490003
UMLS 71 C0038987

Summaries for Sweat Gland Benign Neoplasm

MalaCards based summary : Sweat Gland Benign Neoplasm, also known as sweat gland neoplasm, is related to apocrine sweat gland neoplasm and eccrine sweat gland neoplasm. An important gene associated with Sweat Gland Benign Neoplasm is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Cytoskeleton remodeling Neurofilaments. The drugs nivolumab and Talimogene laherparepvec have been mentioned in the context of this disorder. Affiliated tissues include skin, nk cells and t cells, and related phenotypes are digestive/alimentary and immune system

Related Diseases for Sweat Gland Benign Neoplasm

Diseases related to Sweat Gland Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 451)
# Related Disease Score Top Affiliating Genes
1 apocrine sweat gland neoplasm 33.1 PIP KRT8 KRT7 KRT5 KRT14 CYLD
2 eccrine sweat gland neoplasm 33.0 PIP MAML2 KRT8 KRT7 KRT5 KRT14
3 sweat gland cancer 32.1 TP53 PIP KRT8 KRT7 KRT5 CLEC2A
4 hidradenoma 31.9 ZNF444 PIP MME MAML2 KRT7 KRT5
5 myoepithelioma 31.7 ZNF444 SMARCB1 PLAG1 KRT14 GFAP EWSR1
6 syringocystadenoma papilliferum 31.2 SERPINA3 PIP GFAP
7 eccrine papillary adenoma 31.2 PIP KRT14 CEACAM5
8 mammary paget's disease 30.9 PIP KRT8 KRT7 KRT14
9 apocrine adenoma 30.9 PLAG1 PIP KRT7
10 nodular hidradenoma 30.8 PIP KRT7 CLEC2A CEACAM5
11 eccrine porocarcinoma 30.8 MAML2 KRT7 KRT5 CEACAM5
12 fox-fordyce disease 30.7 PIP CEACAM5
13 hidrocystoma 30.7 PIP KRT8 KRT7 CLEC2A CEACAM5
14 malignant syringoma 30.5 PIP KRT7 CLEC2A CEACAM5
15 malignant acrospiroma 30.5 MAML2 KRT7 KRT5 CLEC2A CEACAM5
16 cystadenoma 30.5 SERPINA3 MME KRT7 CEACAM5
17 eccrine adenocarcinoma 30.4 PIP KRT7 KRT5 CEACAM5
18 cribriform carcinoma 30.2 PIP KRT8 KRT7 KRT5
19 papillary adenocarcinoma 30.1 TP53 PIP KRT7 CEACAM5
20 signet ring cell adenocarcinoma 30.0 TP53 PIP KRT7 CEACAM5
21 soft tissue sarcoma 30.0 TP53 EWSR1
22 secretory meningioma 30.0 SMARCB1 SERPINA3 KRT7 CEACAM5
23 syringoma 30.0 PLAG1 KRT7 GFAP CLEC2A CEACAM5
24 sebaceous adenocarcinoma 30.0 TP53 PIP KRT5 KRT14
25 intestinal benign neoplasm 29.9 TP53 SERPINA3 CEACAM5
26 spiradenoma 29.8 TP53 KRT7 KRT14 CYLD CLEC2A
27 apocrine adenocarcinoma 29.7 TP53 SERPINA3 PIP KRT7 KRT5
28 neuroma 29.7 SMARCB1 SERPINA3 GFAP CD34
29 malignant spiradenoma 29.6 TP53 PIP KRT7 KRT5 CYLD CEACAM5
30 eccrine acrospiroma 29.6 PIP MAML2 KRT7 KRT5 KRT14 CLEC2A
31 adenoid cystic carcinoma 29.2 TP53 SERPINA3 PLAG1 KRT8 KRT7 KRT5
32 skin benign neoplasm 29.2 SERPINA3 PIP KRT7 KRT5 KRT14 CYLD
33 meningioma, familial 29.1 TP53 SMARCB1 SERPINA3 GFAP CD34
34 clear cell hidradenoma 29.0 PIP MME MAML2 KRT7 KRT5 CRTC1
35 adenosquamous carcinoma 28.6 TP53 SERPINA3 MAML2 KRT8 KRT7 KRT5
36 mucoepidermoid carcinoma 28.5 TP53 SERPINA3 MAML2 KRT7 KRT5 KRT14
37 basal cell carcinoma 28.4 TP53 MME KRT8 KRT7 KRT5 KRT14
38 anal canal paget's disease 10.6 PIP KRT7
39 bartholin's gland adenocarcinoma 10.6 PIP KRT7
40 anus basaloid carcinoma 10.6 KRT7 CYLD
41 gastric signet ring cell adenocarcinoma 10.6 PIP KRT7
42 leukoplakia of penis 10.6 KRT7 CEACAM5
43 urethral villous adenoma 10.6 KRT7 CEACAM5
44 bartholin's gland carcinoma 10.6 PIP KRT7
45 ureter squamous cell carcinoma 10.6 KRT7 KRT5
46 bartholin's gland disease 10.6 PIP KRT7
47 vulvar syringoma 10.6 PIP CEACAM5
48 inverted transitional papilloma 10.6 KRT7 KRT5
49 mucinous adenofibroma 10.6 KRT7 CEACAM5
50 vulvar eccrine porocarcinoma 10.6 PIP CEACAM5

Graphical network of the top 20 diseases related to Sweat Gland Benign Neoplasm:



Diseases related to Sweat Gland Benign Neoplasm

Symptoms & Phenotypes for Sweat Gland Benign Neoplasm

MGI Mouse Phenotypes related to Sweat Gland Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.81 CYLD GFAP KRT14 KRT5 KRT8 PBX1
2 immune system MP:0005387 9.7 CD34 CRTC1 CYLD GFAP KRT14 KRT8
3 integument MP:0010771 9.28 CD34 CYLD KRT14 KRT5 MME PBX1

Drugs & Therapeutics for Sweat Gland Benign Neoplasm

Drugs for Sweat Gland Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
3 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Sweat Gland Benign Neoplasm

Cochrane evidence based reviews: sweat gland neoplasms

Genetic Tests for Sweat Gland Benign Neoplasm

Anatomical Context for Sweat Gland Benign Neoplasm

MalaCards organs/tissues related to Sweat Gland Benign Neoplasm:

40
Skin, Nk Cells, T Cells, Breast, Lymph Node, Brain

Publications for Sweat Gland Benign Neoplasm

Articles related to Sweat Gland Benign Neoplasm:

(show all 27)
# Title Authors PMID Year
1
Mammographic and ultrasound findings in poroid hidradenoma of the breast mimicking intraductal papilloma and papillary carcinoma: A case report. 61
29924021 2018
2
Hidradenocarcinoma: Five Years of Local and Systemic Control of a Rare Sweat Gland Neoplasm with Nodal Metastasis. 61
30155386 2018
3
Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature. 61
27870729 2016
4
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. 61
26288440 2015
5
Primary mucinous carcinoma of the skin: the Mayo Clinic experience over the past 2 decades. 61
25627628 2015
6
Combined melanocytic and sweat gland neoplasm: cell subsets harbor an identical HRAS mutation in phacomatosis pigmentokeratotica. 61
24628623 2014
7
Apocrine adenomyoepithelioma--a rare but distinctive primary sweat gland neoplasm. 61
22612240 2012
8
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature. 61
21809988 2011
9
Poroid hidradenoma in a child: an unusual presentation. 61
21276058 2011
10
Aggressive digital papillary adenocarcinoma diagnosed by fine needle aspiration cytology. 61
21187879 2010
11
Axillary apocrine carcinoma with Paget's disease and apocrine naevus. 61
19438526 2009
12
Mucinous carcinoma of the skin: evaluation of lymphatic invasion with D2-40. 61
18806501 2008
13
A rare and unusual case of bilateral, axillary, metachronous apocrine carcinoma. 61
18402127 2007
14
'Nuclear grooves' in nodular hidradenoma: frequency and significance of an unrecognized histopatological feature. 61
17944729 2007
15
Papillary eccrine adenoma in association with cutaneous horn. 61
17492846 2007
16
Primary mucinous carcinoma with direct histopathologic evidence of lymphatic invasion. 61
16865872 2006
17
[Primary mucinous carcinoma of the skin. A case report]. 61
17127853 2006
18
Mohs micrographic surgery of a papillary eccrine adenoma. 61
12472500 2002
19
Aggressive digital papillary adenocarcinoma presenting as finger infection. 61
12351985 2002
20
Apocrine gland carcinoma of the axilla: review of the literature and recommendations for treatment. 61
10199445 1999
21
Mucinous syringometaplasia mimicked by a clear cell hidradenoma with mucinous change. 61
1662242 1991
22
Atypical chondroid syringoma. 61
1652102 1991
23
Papillary eccrine adenoma. A light microscopic and immunohistochemical study. 61
3290282 1988
24
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations. 61
3301927 1987
25
Primary mucinous carcinoma of the skin with metastases to the lymph nodes. 61
3004247 1985
26
Apocrine mixed tumour of the lid. 61
51494 1975
27
[Recurring brain metastases of a sweat gland neoplasm]. 61
4327568 1971

Variations for Sweat Gland Benign Neoplasm

Expression for Sweat Gland Benign Neoplasm

Search GEO for disease gene expression data for Sweat Gland Benign Neoplasm.

Pathways for Sweat Gland Benign Neoplasm

Pathways related to Sweat Gland Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.17 TP53 PBX1 KRT5 KRT14
2
Show member pathways
11.05 KRT8 KRT7 KRT5 KRT14 GFAP

GO Terms for Sweat Gland Benign Neoplasm

Cellular components related to Sweat Gland Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.1 ZNF444 TP53 SMARCB1 SERPINA3 PLAG1 PIP
2 cell periphery GO:0071944 9.33 KRT8 KRT14 CD34
3 keratin filament GO:0045095 9.26 KRT8 KRT7 KRT5 KRT14
4 intermediate filament GO:0005882 9.02 KRT8 KRT7 KRT5 KRT14 GFAP

Biological processes related to Sweat Gland Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replicative senescence GO:0090399 9.26 TP53 MME
2 keratinization GO:0031424 9.26 KRT8 KRT7 KRT5 KRT14
3 hemidesmosome assembly GO:0031581 9.16 KRT5 KRT14
4 cornification GO:0070268 8.92 KRT8 KRT7 KRT5 KRT14

Sources for Sweat Gland Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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