MCID: SWT002
MIFTS: 41

Sweat Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sweat Gland Cancer

MalaCards integrated aliases for Sweat Gland Cancer:

Name: Sweat Gland Cancer 12 15
Sweat Gland Carcinoma 12 15 17
Primary Malignant Neoplasm of Sweat Gland 70
Malignant Tumor of the Sweat Gland 12
Malignant Neoplasm of Sweat Gland 12
Carcinoma of the Sweat Gland 12
Sweat Gland Neoplasms 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2095 DOID:5667
NCIt 50 C4810 C6938
SNOMED-CT 67 254708001 255095005
ICD10 32 C44
UMLS 70 C0038987 C1321904 C1367882 more

Summaries for Sweat Gland Cancer

MalaCards based summary : Sweat Gland Cancer, also known as sweat gland carcinoma, is related to eccrine adenocarcinoma and eccrine porocarcinoma. An important gene associated with Sweat Gland Cancer is PIP (Prolactin Induced Protein), and among its related pathways/superpathways are Developmental Biology and Relaxin signaling pathway. The drugs Talimogene laherparepvec and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lymph node, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Sweat Gland Cancer

Diseases related to Sweat Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 547)
# Related Disease Score Top Affiliating Genes
1 eccrine adenocarcinoma 32.0 PIP KRT7 KRT5 CEACAM5
2 eccrine porocarcinoma 31.9 KRT7 KRT19 CEACAM5
3 eyelid carcinoma 31.3 PIP KRT7 KRT20
4 eccrine sweat gland cancer 31.0 TP53 PIP KRT7 KRT5 KRT20 KRT19
5 apocrine adenocarcinoma 30.8 PIP PGR KRT7 KRT5 GATA3 ESR1
6 appendix adenocarcinoma 30.8 SYP KRT7 KRT20
7 nodular hidradenoma 30.6 PIP CEACAM5
8 skin benign neoplasm 30.5 PIP KRT7 KRT5 KRT20
9 breast papillary carcinoma 30.5 SYP PGR KRT5 ESR1 ERBB2
10 breast secretory carcinoma 30.5 PIP KRT5
11 adenocarcinoma 30.4 TP53 KRT7 KRT20 ERBB2 CEACAM5
12 spiradenoma 30.3 TP53 KRT7 KRT15
13 malignant acrospiroma 30.2 PIP KRT7 KRT5 CEACAM5
14 mammary analogue secretory carcinoma 30.0 TP53 PLIN2
15 cystic teratoma 30.0 TP53 SYP KRT7 KRT20
16 meibomian cyst 29.9 SYP PLIN2 KRT7 KRT20
17 syringoma 29.9 KRT7 KRT19 ESR1 CEACAM5
18 papillary carcinoma 29.9 SYP PGR KRT7 KRT20 KRT19 ESR1
19 malignant syringoma 29.8 PIP KRT7 KRT5 KRT20 KRT15 CEACAM5
20 hidradenoma 29.8 PIP KRT7 KRT5 KRT15 CEACAM5
21 teratoma 29.8 TP53 SYP KRT7 KRT20 CEACAM5
22 benign mesothelioma 29.7 KRT7 KRT5 KRT20 KRT19 CEACAM5
23 neuroendocrine carcinoma 29.7 SYP KRT7 KRT20 KRT19 CEACAM5
24 merkel cell carcinoma 29.5 TP53 SYP KRT8 KRT7 KRT20
25 in situ carcinoma 29.5 TP53 PIP PGR KRT8 KRT5 ESR1
26 adenoid cystic carcinoma 29.5 TP53 PGR KRT7 KRT5 KRT20 KRT19
27 papillary adenocarcinoma 29.4 TP53 PIP PGR KRT7 KRT19 ERBB2
28 wilms tumor 1 29.4 TP53 PGR KRT7 ESR1 ERBB2 AR
29 eccrine papillary adenocarcinoma 29.3 PIP PGR KRT8 KRT7 KRT5 KRT19
30 mucinous adenocarcinoma 29.3 TP53 PGR KRT7 KRT20 KRT19 ESR1
31 mucoepidermoid carcinoma 29.3 TP53 KRT7 KRT5 KRT19 ERBB2 CEACAM5
32 malignant spiradenoma 29.2 TP53 PLIN2 PIP PGR KRT7 KRT5
33 mammary paget's disease 29.2 PIP PGR KRT8 KRT7 KRT20 ESR1
34 vulvar apocrine adenocarcinoma 29.2 PIP KRT7 KRT5 KRT20 KRT19 CEACAM5
35 ductal carcinoma in situ 29.1 TP53 PIP PGR KRT8 KRT5 ESR1
36 papilloma 29.1 TP53 KRT8 KRT7 KRT5 KRT20 ERBB2
37 lung cancer susceptibility 3 29.1 TP53 PIP KRT7 KRT20 KRT19 ERBB2
38 hidrocystoma 28.9 PIP KRT8 KRT7 KRT19 KRT15 CEACAM5
39 cribriform carcinoma 28.7 PIP PGR KRT8 KRT7 KRT5 GATA3
40 basal cell carcinoma 28.5 TP53 SYP KRT8 KRT7 KRT5 KRT20
41 breast ductal carcinoma 27.8 TP53 PIP PGR KRT8 KRT7 KRT5
42 skin carcinoma 27.1 TP53 SYP PIP PGR KRT8 KRT7
43 aggressive digital papillary adenocarcinoma 11.2
44 rare tumor 10.5
45 leukoplakia of penis 10.4 KRT7 CEACAM5
46 anal canal paget's disease 10.4 PIP KRT7
47 gastric signet ring cell adenocarcinoma 10.4 PIP KRT7
48 ureter squamous cell carcinoma 10.4 KRT7 KRT5
49 bartholin's gland carcinoma 10.4 PIP KRT7
50 fox-fordyce disease 10.4 PIP CEACAM5

Graphical network of the top 20 diseases related to Sweat Gland Cancer:



Diseases related to Sweat Gland Cancer

Symptoms & Phenotypes for Sweat Gland Cancer

MGI Mouse Phenotypes related to Sweat Gland Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.13 AR ERBB2 ESR1 GATA3 KRT15 KRT19
2 endocrine/exocrine gland MP:0005379 10.02 AR ERBB2 ESR1 GATA3 KRT19 PGR
3 immune system MP:0005387 10.02 AR ESR1 GATA3 KRT19 KRT5 KRT8
4 embryo MP:0005380 10.01 AR ERBB2 ESR1 GATA3 KRT19 KRT8
5 integument MP:0010771 9.91 AR ERBB2 ESR1 GATA3 KRT19 KRT5
6 neoplasm MP:0002006 9.63 AR ERBB2 ESR1 KRT19 PGR TP53
7 normal MP:0002873 9.56 AR ERBB2 ESR1 GATA3 KRT19 PGR
8 reproductive system MP:0005389 9.32 AR ERBB2 ESR1 GATA3 KRT19 KRT8

Drugs & Therapeutics for Sweat Gland Cancer

Drugs for Sweat Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
2
nivolumab Approved Phase 2 946414-94-4
3 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Sweat Gland Cancer

Genetic Tests for Sweat Gland Cancer

Anatomical Context for Sweat Gland Cancer

MalaCards organs/tissues related to Sweat Gland Cancer:

40
Skin, Breast, Lymph Node, Bone, Bone Marrow, Kidney, Ovary

Publications for Sweat Gland Cancer

Articles related to Sweat Gland Cancer:

(show top 50) (show all 287)
# Title Authors PMID Year
1
MYB Translocations in Both Myoepithelial and Ductoglandular Epithelial Cells in Adenoid Cystic Carcinoma: A Histopathologic and Genetic Reappraisal in Six Primary Cutaneous Cases. 61
32732690 2021
2
A case of endocrine mucin-producing sweat gland carcinoma with distant metastasis. 61
33660318 2021
3
Simultaneous presentation of orbital mantle cell lymphoma and endocrine mucin-producing sweat gland carcinoma. 61
33657963 2021
4
Endocrine mucin-producing sweat gland carcinoma and associated primary cutaneous mucinous carcinoma: Review of the literature. 61
33590507 2021
5
Atypical presentation of an endocrine mucin-producing sweat gland carcinoma of the eyelid. 61
32116079 2021
6
Multicentric endocrine mucin-producing sweat gland carcinoma and mucinous carcinoma of the skin: A case report. 61
33047834 2021
7
Endocrine mucin-producing sweat gland carcinoma of the peno-scrotum with systemic metastases: A rare case report. 61
33433437 2021
8
Next Generation Sequencing analysis suggests varied multistep mutational pathogenesis for Endocrine Mucin Producing Sweat Gland Carcinoma with comments on INSM1 and MUC2 suggesting a conjunctival origin. 61
33515627 2021
9
Metastatic human papillomavirus-positive oropharyngeal carcinoma mimicking primary cutaneous sweat-gland carcinoma. 61
33442919 2021
10
Comparative performance of insulinoma-associated protein 1 (INSM1) and routine immunohistochemical markers of neuroendocrine differentiation in the diagnosis of endocrine mucin-producing sweat gland carcinoma. 61
32745280 2021
11
Endocrine Mucin-Producing Sweat Gland Carcinoma: Two New Eyelid Cases and Review of the Literature. 61
32188317 2020
12
A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma: Is it Still an Under-Recognized Entity? 61
33362513 2020
13
Surgical management and lymph-node biopsy of rare malignant cutaneous adnexal carcinomas: a population-based analysis of 7591 patients. 61
32965516 2020
14
Sweat gland carcinoma of the left axilla with disseminated carcinomatosis of the bone marrow. 61
32202308 2020
15
Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid With Locoregional Metastasis to the Parotid Gland. 61
31977506 2020
16
An Update on Endocrine Mucin-producing Sweat Gland Carcinoma: Clinicopathologic Study of 63 Cases and Comparative Analysis. 61
32452870 2020
17
Next-generation sequencing implicates oncogenic roles for p53 and JAK/STAT signaling in microcystic adnexal carcinomas. 61
31857679 2020
18
Four male cases of endocrine mucin-producing sweat gland carcinoma: Specific gender differences in East Asia. 61
32160405 2020
19
Endocrine mucin-producing sweat gland carcinoma - newly described skin appendageal tumours. 61
32342939 2020
20
Polymorphous sweat gland carcinoma found to have MYB rearrangement. 61
31667857 2020
21
Local invasion in endocrine mucin-producing sweat gland carcinoma: Still an open issue. 61
31755569 2020
22
Endocrine Mucin-Producing Sweat Gland Carcinoma in an Elderly Man. 61
31995546 2020
23
Sentinel lymph node biopsy of primary apocrine sweat gland carcinoma of the axilla: A case report and review of the literature. 61
33160170 2020
24
Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors. 61
31558783 2020
25
Perineural and Vascular Invasion in an Endocrine Mucin-Producing Sweat Gland Carcinoma of the Ear with Associated Mucinous Carcinoma. 61
32232034 2019
26
Delayed treatment of endocrine mucin-producing sweat gland carcinoma initially diagnosed as a chalazion. 61
31516999 2019
27
Re-evaluation of "Polymorphous Sweat Gland Carcinoma". 61
30085958 2019
28
Endocrine mucin-producing sweat gland carcinoma (EMPSGC) of the eyelid: Clinicopathologic features, immunohistochemical findings and review of literature. 61
31332149 2019
29
Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature. 61
31335409 2019
30
Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma: Informed by a Systematic Review. 61
31268498 2019
31
Gene expression profiling in aggressive digital papillary adenocarcinoma sheds light on the architecture of a rare sweat gland carcinoma. 61
30472730 2019
32
Apocrine adenocarcinoma of the eyelid: case report and literature review on management. 61
31220897 2019
33
[Digital papillary adenocarcinoma : Four case reports with brief literature review]. 61
30478600 2019
34
Malignant Sweat Gland Tumors. 61
30497677 2019
35
Endocrine mucin-producing sweat gland carcinoma of the scalp treated with Mohs micrographic surgery. 61
30306119 2018
36
Bilateral primary histiocytoid eccrine sweat gland carcinoma of eyelids. 61
27132240 2018
37
Neuroendocrine cells associated with endocrine mucin-producing sweat gland carcinoma: a potential precursor lesion? 61
29908841 2018
38
Polymorphous Sweat Gland Carcinoma: An Immunohistochemical and Molecular Study. 61
29533280 2018
39
Endocrine mucin-producing sweat gland carcinoma of the eyelid: A clinical and histological conundrum. 61
29941769 2018
40
Endocrine mucin-producing sweat gland carcinoma: A study of 11 cases with molecular analysis. 61
29943394 2018
41
Endocrine mucin-producing sweat gland carcinoma: Clinicopathologic, immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression. 61
29882219 2018
42
Dermoscopic features of endocrine mucin-producing sweat gland carcinoma. 61
29178396 2018
43
Primary cutaneous secretory carcinoma: A previously overlooked low-grade sweat gland carcinoma. 61
29205457 2018
44
Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid Associated With Mucinous Adenocarcinoma. 61
28902090 2018
45
Pure mucinous (colloid) adenocarcinoma of the conjunctiva. 61
29028127 2018
46
Endocrine Mucin-Producing Sweat Gland Carcinoma Treated With Mohs Micrographic Surgery. 61
28394861 2017
47
Endocrine mucin-producing sweat gland carcinoma with GATA3 expression: report of two cases. 61
29078998 2017
48
[Atypical course of an apocrine sweat gland carcinoma of the axilla : A very rare malignant tumor and its interdisciplinary treatment]. 61
28567510 2017
49
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual. 61
28350693 2017
50
Cutaneous Sweat Gland Carcinomas with Basaloid Differentiation: An Update with Emphasis on Differential Diagnoses. 61
28802502 2017

Variations for Sweat Gland Cancer

Expression for Sweat Gland Cancer

Search GEO for disease gene expression data for Sweat Gland Cancer.

Pathways for Sweat Gland Cancer

GO Terms for Sweat Gland Cancer

Cellular components related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.03 TP53 PLIN2 PIP PGR KRT8 KRT7
2 cytosol GO:0005829 9.73 TP53 PLIN2 PGR KRT8 KRT7 KRT5
3 keratin filament GO:0045095 9.33 KRT8 KRT7 KRT5
4 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT8 KRT19
5 intermediate filament GO:0005882 9.1 KRT8 KRT7 KRT5 KRT20 KRT19 KRT15

Biological processes related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.8 TP53 PGR GATA3 ESR1
2 positive regulation of gene expression GO:0010628 9.8 TP53 PIP GATA3 ERBB2 AR
3 protein deubiquitination GO:0016579 9.73 TP53 GATA3 ESR1 AR
4 male gonad development GO:0008584 9.7 GATA3 ESR1 AR
5 cellular response to estrogen stimulus GO:0071391 9.55 ESR1 AR
6 mammary gland alveolus development GO:0060749 9.54 ESR1 AR
7 response to estrogen GO:0043627 9.54 KRT19 GATA3 ESR1
8 uterus development GO:0060065 9.51 GATA3 ESR1
9 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.48 TP53 ESR1
10 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.46 TP53 ESR1
11 keratinization GO:0031424 9.43 KRT8 KRT7 KRT5 KRT20 KRT19 KRT15
12 intracellular steroid hormone receptor signaling pathway GO:0030518 9.33 PGR ESR1 AR
13 cell differentiation involved in embryonic placenta development GO:0060706 9.32 KRT8 KRT19
14 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.26 PGR AR
15 cornification GO:0070268 9.1 KRT8 KRT7 KRT5 KRT20 KRT19 KRT15

Molecular functions related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.36 TP53 SYP PLIN2 PIP PGR KRT8
2 DNA-binding transcription factor activity GO:0003700 9.88 TP53 PGR GATA3 ESR1 AR
3 transcription factor binding GO:0008134 9.8 TP53 GATA3 ESR1 AR
4 identical protein binding GO:0042802 9.76 TP53 SYP PIP PGR GATA3 ESR1
5 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.72 TP53 PGR GATA3 ESR1 AR
6 ATPase binding GO:0051117 9.61 PGR ESR1 AR
7 scaffold protein binding GO:0097110 9.54 KRT8 KRT5 KRT15
8 nuclear receptor activity GO:0004879 9.43 PGR ESR1 AR
9 RNA polymerase II transcription coactivator binding GO:0001225 9.4 PGR AR
10 steroid binding GO:0005496 9.13 PGR ESR1 AR
11 structural constituent of cytoskeleton GO:0005200 8.92 KRT5 KRT20 KRT19 KRT15

Sources for Sweat Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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