MCID: SWT002
MIFTS: 42

Sweat Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sweat Gland Cancer

MalaCards integrated aliases for Sweat Gland Cancer:

Name: Sweat Gland Cancer 12 15
Sweat Gland Carcinoma 12 15
Sweat Gland Neoplasms 44 73
Sweat Gland Neoplasm 12 15
Primary Malignant Neoplasm of Sweat Gland 73
Malignant Tumor of the Sweat Gland 12
Malignant Neoplasm of Sweat Gland 12
Carcinoma of the Sweat Gland 12
Tumor of the Sweat Gland 12
Neoplasm of Sweat Gland 12
Sweat Gland Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2095 DOID:2664 DOID:5667
ICD10 33 C44
SNOMED-CT 68 32272007 12933008
MeSH 44 D013544

Summaries for Sweat Gland Cancer

MalaCards based summary : Sweat Gland Cancer, also known as sweat gland carcinoma, is related to apocrine sweat gland neoplasm and eccrine sweat gland neoplasm. An important gene associated with Sweat Gland Cancer is KRT7 (Keratin 7), and among its related pathways/superpathways are Developmental Biology and Circadian entrainment. Affiliated tissues include skin, lung and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Sweat Gland Cancer

Diseases related to Sweat Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 380)
# Related Disease Score Top Affiliating Genes
1 apocrine sweat gland neoplasm 33.5 KRT14 KRT15 KRT5 KRT7 KRT8
2 eccrine sweat gland neoplasm 32.1 KRT15 KRT20 KRT5 KRT7 TP53
3 eccrine adenocarcinoma 31.9 ESR1 KRT7
4 apocrine adenocarcinoma 31.5 ERBB2 ESR1 KRT15 KRT5 PGR
5 eyelid carcinoma 30.8 KRT20 KRT7
6 eccrine papillary adenocarcinoma 30.4 KRT7 PGR
7 spiradenoma 30.2 KRT14 KRT7 TP53
8 malignant spiradenoma 30.1 KRT5 KRT7 TP53
9 mucoepidermoid carcinoma 30.0 ERBB2 KRT14 KRT7
10 hidradenocarcinoma 29.9 ERBB2 ESR1 KRT5 KRT7 TP53
11 papillary carcinoma 29.9 ERBB2 KRT20 KRT7 PGR
12 papillary adenocarcinoma 29.9 ERBB2 KRT7 PGR TP53
13 spindle cell carcinoma 29.8 KRT14 KRT5 KRT7 PGR SYP
14 merkel cell carcinoma 29.3 ENO2 KRT20 KRT7 KRT8 SYP TP53
15 malignant acrospiroma 11.5
16 hidradenoma 11.3
17 acrospiroma 11.3
18 myoepithelioma 11.1
19 eccrine papillary adenoma 11.1
20 eccrine porocarcinoma 11.1
21 balloon cell malignant melanoma 10.3 KRT5 KRT7
22 ceruminoma 10.3 KRT5 KRT7
23 cystic basal cell carcinoma 10.3 KRT20 KRT7
24 benign mesothelioma 10.3 KRT5 KRT7
25 seminal vesicle adenocarcinoma 10.3 KRT20 KRT7
26 transverse colon cancer 10.3 KRT20 KRT7
27 appendix adenocarcinoma 10.3 KRT20 KRT7
28 glandular cystitis 10.3 KRT20 KRT7
29 krukenberg carcinoma 10.3 KRT20 KRT7
30 bile duct mucoepidermoid carcinoma 10.3 KRT5 KRT7
31 large intestine adenocarcinoma 10.3 KRT20 KRT7
32 endolymphatic sac tumor 10.3 KRT7 KRT8
33 linitis plastica 10.3 KRT20 KRT7
34 lung acinar adenocarcinoma 10.3 KRT20 KRT7
35 intratubular embryonal carcinoma 10.3 KRT20 KRT7
36 ovary neuroendocrine neoplasm 10.3 KRT7 SYP
37 bile duct cystadenocarcinoma 10.3 KRT20 KRT7
38 bile duct adenoma 10.3 KRT20 KRT7
39 endosalpingiosis 10.3 KRT7 PGR
40 jejunal adenocarcinoma 10.3 KRT20 KRT7
41 ovarian mucinous adenocarcinoma 10.3 KRT20 KRT7
42 breast papillary carcinoma 10.3 KRT5 SYP
43 ovarian large-cell neuroendocrine carcinoma 10.3 KRT20 SYP
44 thymus adenocarcinoma 10.3 KRT20 KRT7
45 morpheaform basal cell carcinoma 10.3 KRT15 KRT20
46 appendix disease 10.3 KRT20 KRT7
47 benign metastasizing leiomyoma 10.3 KRT7 PGR
48 adenoma of the pancreas 10.3 KRT20 SYP
49 gastric diffuse adenocarcinoma 10.3 KRT20 KRT7
50 nasal cavity cancer 10.3 KRT7 KRT8

Graphical network of the top 20 diseases related to Sweat Gland Cancer:



Diseases related to Sweat Gland Cancer

Symptoms & Phenotypes for Sweat Gland Cancer

GenomeRNAi Phenotypes related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.58 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.58 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.58 KRT18 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.58 KRT5 KRT8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.58 KRT5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.58 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.58 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.58 KRT18 KRT5 KRT7 KRT8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.58 KRT7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.58 KRT18
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.58 KRT5 KRT7

MGI Mouse Phenotypes related to Sweat Gland Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.76 ERBB2 ESR1 GATA3 KRT14 KRT15 KRT5
2 craniofacial MP:0005382 9.73 ENO2 ERBB2 GATA3 KRT14 KRT5 TP53
3 embryo MP:0005380 9.5 ERBB2 ESR1 GATA3 KRT18 KRT8 PGR
4 integument MP:0010771 9.17 ERBB2 ESR1 GATA3 KRT14 KRT5 PGR

Drugs & Therapeutics for Sweat Gland Cancer

Search Clinical Trials , NIH Clinical Center for Sweat Gland Cancer

Cochrane evidence based reviews: sweat gland neoplasms

Genetic Tests for Sweat Gland Cancer

Anatomical Context for Sweat Gland Cancer

MalaCards organs/tissues related to Sweat Gland Cancer:

41
Skin, Lung, Ovary, Prostate, Thymus, Pineal, Appendix

Publications for Sweat Gland Cancer

Articles related to Sweat Gland Cancer:

(show all 37)
# Title Authors Year
1
Gene expression profiling in aggressive digital papillary adenocarcinoma sheds light on the architecture of a rare sweat gland carcinoma. ( 30472730 )
2018
2
Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid Associated With Mucinous Adenocarcinoma. ( 28902090 )
2018
3
Bilateral primary histiocytoid eccrine sweat gland carcinoma of eyelids. ( 27132240 )
2018
4
Dermoscopic features of endocrine mucin-producing sweat gland carcinoma. ( 29178396 )
2018
5
Primary cutaneous secretory carcinoma: A previously overlooked low-grade sweat gland carcinoma. ( 29205457 )
2018
6
Polymorphous Sweat Gland Carcinoma: An Immunohistochemical and Molecular Study. ( 29533280 )
2018
7
Endocrine mucin-producing sweat gland carcinoma: Clinicopathologic, immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression. ( 29882219 )
2018
8
Neuroendocrine cells associated with endocrine mucin-producing sweat gland carcinoma: a potential precursor lesion? ( 29908841 )
2018
9
Endocrine mucin-producing sweat gland carcinoma of the eyelid: A clinical and histological conundrum. ( 29941769 )
2018
10
Endocrine mucin-producing sweat gland carcinoma: A study of 11 cases with molecular analysis. ( 29943394 )
2018
11
Re-evaluation of "Polymorphous Sweat Gland Carcinoma". ( 30085958 )
2018
12
Endocrine mucin-producing sweat gland carcinoma of the scalp treated with Mohs micrographic surgery. ( 30306119 )
2018
13
Endocrine Mucin-Producing Sweat Gland Carcinoma: An Uncommon Presentation. ( 27419539 )
2017
14
Treatment of Sweat gland carcinoma with Topical Aminolevulinic Acid Photodynamic therapy: An effective treatment method to improve surgical outcomes. ( 28034762 )
2017
15
Endocrine Mucin-Producing Sweat Gland Carcinoma, a Histological Challenge. ( 28299221 )
2017
16
Endocrine Mucin-Producing Sweat Gland Carcinoma Treated With Mohs Micrographic Surgery. ( 28394861 )
2017
17
F-18 FDG PET/CT Imaging of Eccrine Sweat Gland Carcinoma of the Scrotum with Extensive Regional and Distant Metastases. ( 28660220 )
2017
18
Endocrine mucin-producing sweat gland carcinoma with GATA3 expression: report of two cases. ( 29078998 )
2017
19
Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid: A Report of a Case With Molecular Analysis. ( 26675355 )
2016
20
Polymorphous sweat gland carcinoma: a report of two cases. ( 26956440 )
2016
21
Histopathology of endocrine mucin-producing sweat gland carcinoma of the eyelid. ( 27085285 )
2016
22
Sweat Gland Carcinoma With Lymphadenopathy. ( 28712249 )
2016
23
WT1 expression in endocrine mucin-producing sweat gland carcinoma: a study of 13 cases. ( 25219513 )
2014
24
Neck sweat gland cancer hemorrhage. Case study. ( 23788972 )
2013
25
Histiocytoid eccrine sweat gland carcinoma of the eyelid: report of a case. ( 16869823 )
2006
26
CD34-positive stromal cells and alpha-smooth muscle actin-positive stromal cells in the tumor capsule of skin sweat gland neoplasms. ( 11940203 )
2002
27
Sweat gland carcinoma of the foot: a review and patient report. ( 9827961 )
1998
28
Eccrine sweat gland carcinoma of the scrotum with associated extramammary Paget's disease. ( 9372896 )
1997
29
Adenocarcinoma of the mammary-like glands of the vulva: a concept unifying sweat gland carcinoma of the vulva, carcinoma of supernumerary mammary glands and extramammary Paget's disease. ( 8040464 )
1994
30
Metastatic sweat gland carcinoma: response to 5-fluorouracil infusion. ( 2770311 )
1989
31
Metastatic sweat gland carcinoma in an adolescent: a case report. ( 3224904 )
1988
32
Extramammary Paget's disease. Arising in knee region in association with sweat gland carcinoma. ( 6205637 )
1984
33
Sweat gland carcinoma: a clinico-pathological reappraisal. ( 1249938 )
1976
34
Sweat gland carcinoma with regional lymph node metastasis. ( 1155958 )
1975
35
Eccrine sweat gland carcinoma with metastases. ( 5060426 )
1972
36
Intracranial metastasis of sweat gland carcinoma. Case report. ( 4288759 )
1966
37
Sweat Gland Carcinoma of the Breast: A Morpho-Histological Study. ( 29639017 )
1932

Variations for Sweat Gland Cancer

Expression for Sweat Gland Cancer

Search GEO for disease gene expression data for Sweat Gland Cancer.

Pathways for Sweat Gland Cancer

GO Terms for Sweat Gland Cancer

Cellular components related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.95 ENO2 KRT14 KRT15 KRT18 KRT5 KRT7
2 cytosol GO:0005829 9.93 ENO2 ERBB2 ESR1 KRT14 KRT15 KRT18
3 cell periphery GO:0071944 9.43 KRT14 KRT18 KRT8
4 keratin filament GO:0045095 9.35 KRT14 KRT18 KRT5 KRT7 KRT8
5 intermediate filament GO:0005882 9.17 KRT14 KRT15 KRT18 KRT20 KRT5 KRT7
6 cytoplasm GO:0005737 10.11 ENO2 ERBB2 ESR1 KRT14 KRT18 KRT20
7 nucleus GO:0005634 10.06 ERBB2 ESR1 GATA3 KRT14 KRT15 KRT18

Biological processes related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.54 KRT14 KRT15 KRT5
2 keratinization GO:0031424 9.5 KRT14 KRT15 KRT18 KRT20 KRT5 KRT7
3 uterus development GO:0060065 9.4 ESR1 GATA3
4 hemidesmosome assembly GO:0031581 9.32 KRT14 KRT5
5 hepatocyte apoptotic process GO:0097284 9.26 KRT18 KRT8
6 cornification GO:0070268 9.17 KRT14 KRT15 KRT18 KRT20 KRT5 KRT7
7 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.16 ESR1 TP53

Molecular functions related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 ENO2 ERBB2 ESR1 GATA3 KRT14 KRT15
2 structural constituent of cytoskeleton GO:0005200 9.26 KRT14 KRT15 KRT20 KRT5
3 scaffold protein binding GO:0097110 8.92 KRT15 KRT18 KRT5 KRT8

Sources for Sweat Gland Cancer

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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
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31 HMDB
32 HPO
33 ICD10
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62 PubMed
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69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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