MCID: SWT002
MIFTS: 41

Sweat Gland Cancer

Categories: Skin diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Sweat Gland Cancer

MalaCards integrated aliases for Sweat Gland Cancer:

Name: Sweat Gland Cancer 12 15
Sweat Gland Neoplasms 44 73
Sweat Gland Neoplasm 12 15
Primary Malignant Neoplasm of Sweat Gland 73
Malignant Tumor of the Sweat Gland 12
Malignant Neoplasm of Sweat Gland 12
Tumor of the Sweat Gland 12
Neoplasm of Sweat Gland 12
Sweat Gland Tumor 12

Classifications:



Summaries for Sweat Gland Cancer

MalaCards based summary : Sweat Gland Cancer, also known as sweat gland neoplasms, is related to eccrine adenocarcinoma and eccrine sweat gland neoplasm. An important gene associated with Sweat Gland Cancer is KRT7 (Keratin 7), and among its related pathways/superpathways are Developmental Biology and Circadian entrainment. The drugs nivolumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin and smooth muscle, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Sweat Gland Cancer

Diseases related to Sweat Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 304)
# Related Disease Score Top Affiliating Genes
1 eccrine adenocarcinoma 32.4 ESR1 KRT7
2 eccrine sweat gland neoplasm 31.1 DAND5 KRT15 KRT20 KRT7 TP53
3 hidradenocarcinoma 30.4 ERBB2 ESR1 KRT5 KRT7 TP53
4 papillary adenocarcinoma 29.5 ERBB2 KRT7 PGR TP53
5 apocrine adenocarcinoma 29.4 AR ERBB2 ESR1 KRT5 KRT7 PGR
6 hidradenoma 11.1
7 acrospiroma 11.1
8 inverted transitional papilloma 11.0 KRT5 KRT7
9 balloon cell malignant melanoma 11.0 KRT5 KRT7
10 bile duct mucoepidermoid carcinoma 10.9 KRT5 KRT7
11 papillary adenoma 10.9 KRT5 KRT7
12 epidermolysis bullosa simplex, autosomal recessive 1 10.9 KRT14 KRT5
13 epidermolysis bullosa simplex, localized 10.9 KRT14 KRT5
14 lichen planopilaris 10.8 KRT14 KRT5
15 endosalpingiosis 10.8 KRT7 PGR
16 breast cystic hypersecretory carcinoma 10.8 ERBB2 KRT5
17 malignant mixed mullerian tumor 10.8 KRT7 PGR
18 cystic basal cell carcinoma 10.8 KRT20 KRT7
19 benign metastasizing leiomyoma 10.8 KRT7 PGR
20 vaginal benign neoplasm 10.8 KRT20 KRT7
21 seminal vesicle adenocarcinoma 10.8 KRT20 KRT7
22 epidermolysis bullosa simplex, generalized 10.8 KRT14 KRT5
23 transverse colon cancer 10.8 KRT20 KRT7
24 appendix adenocarcinoma 10.8 KRT20 KRT7
25 vaginal adenoma 10.8 KRT20 KRT7
26 vaginal tubulovillous adenoma 10.8 KRT20 KRT7
27 eyelid neoplasm 10.8 KRT20 KRT7
28 glandular cystitis 10.8 KRT20 KRT7
29 krukenberg carcinoma 10.8 KRT20 KRT7
30 large intestine adenocarcinoma 10.8 KRT20 KRT7
31 linitis plastica 10.7 KRT20 KRT7
32 scirrhous adenocarcinoma 10.7 ERBB2 PGR
33 lung acinar adenocarcinoma 10.7 KRT20 KRT7
34 breast apocrine carcinoma 10.7 ERBB2 PGR
35 epidermolysis bullosa simplex with mottled pigmentation 10.7 KRT14 KRT5
36 adenoid squamous cell carcinoma 10.7 KRT20 KRT7
37 breast mucoepidermoid carcinoma 10.7 ERBB2 PGR
38 mucinous bronchioloalveolar adenocarcinoma 10.7 KRT20 KRT7
39 intracystic papillary adenoma 10.7 ERBB2 PGR
40 progesterone-receptor negative breast cancer 10.7 ERBB2 PGR
41 bile duct cystadenocarcinoma 10.7 KRT20 KRT7
42 intratubular embryonal carcinoma 10.7 KRT20 KRT7
43 ovarian mucinous adenocarcinoma 10.7 KRT20 KRT7
44 basal cell carcinoma, infundibulocystic 10.7 KRT14 KRT20
45 ovary neuroendocrine neoplasm 10.7 KRT7 SYP
46 thymus adenocarcinoma 10.7 KRT20 KRT7
47 proliferating trichilemmal cyst 10.7 KRT7 KRT8
48 gastric diffuse adenocarcinoma 10.7 KRT20 KRT7
49 endolymphatic sac tumor 10.7 KRT7 KRT8
50 endocervical carcinoma 10.7 ESR1 KRT7

Graphical network of the top 20 diseases related to Sweat Gland Cancer:



Diseases related to Sweat Gland Cancer

Symptoms & Phenotypes for Sweat Gland Cancer

GenomeRNAi Phenotypes related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.44 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.44 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 KRT5 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.44 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.44 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.44 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.44 KRT5 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.44 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.44 KRT5 KRT7

MGI Mouse Phenotypes related to Sweat Gland Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.97 KRT14 KRT15 KRT5 KRT8 AR TP53
2 embryo MP:0005380 9.87 KRT8 AR PGR DAND5 TP53 ERBB2
3 integument MP:0010771 9.8 KRT14 KRT5 AR PGR TP53 ERBB2
4 limbs/digits/tail MP:0005371 9.63 KRT5 AR PGR TP53 ERBB2 ESR1
5 neoplasm MP:0002006 9.43 KRT14 AR PGR TP53 ERBB2 ESR1
6 reproductive system MP:0005389 9.17 ESR1 KRT14 KRT8 AR PGR TP53

Drugs & Therapeutics for Sweat Gland Cancer

Drugs for Sweat Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies Phase 2
3 Immunoglobulins Phase 2
4 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Sweat Gland Cancer

Cochrane evidence based reviews: sweat gland neoplasms

Genetic Tests for Sweat Gland Cancer

Anatomical Context for Sweat Gland Cancer

MalaCards organs/tissues related to Sweat Gland Cancer:

41
Skin, Smooth Muscle

Publications for Sweat Gland Cancer

Articles related to Sweat Gland Cancer:

# Title Authors Year
1
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. ( 26288440 )
2015
2
Combined melanocytic and sweat gland neoplasm: cell subsets harbor an identical HRAS mutation in phacomatosis pigmentokeratotica. ( 24628623 )
2014
3
Neck sweat gland cancer hemorrhage. Case study. ( 23788972 )
2013
4
Apocrine adenomyoepithelioma--a rare but distinctive primary sweat gland neoplasm. ( 22612240 )
2012
5
CD34-positive stromal cells and alpha-smooth muscle actin-positive stromal cells in the tumor capsule of skin sweat gland neoplasms. ( 11940203 )
2002

Variations for Sweat Gland Cancer

Expression for Sweat Gland Cancer

Search GEO for disease gene expression data for Sweat Gland Cancer.

Pathways for Sweat Gland Cancer

GO Terms for Sweat Gland Cancer

Cellular components related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.9 AR ERBB2 ESR1 KRT14 KRT15 KRT20
2 keratin filament GO:0045095 9.26 KRT14 KRT5 KRT7 KRT8
3 intermediate filament GO:0005882 9.1 KRT14 KRT15 KRT20 KRT5 KRT7 KRT8

Biological processes related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.61 KRT14 KRT15 KRT5
2 mammary gland alveolus development GO:0060749 9.46 AR ESR1
3 steroid hormone mediated signaling pathway GO:0043401 9.43 AR ESR1 PGR
4 keratinization GO:0031424 9.43 KRT14 KRT15 KRT20 KRT5 KRT7 KRT8
5 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.4 ESR1 TP53
6 hemidesmosome assembly GO:0031581 9.37 KRT14 KRT5
7 positive regulation of transcription by RNA polymerase III GO:0045945 9.32 AR ERBB2
8 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.16 AR PGR
9 cornification GO:0070268 9.1 KRT14 KRT15 KRT20 KRT5 KRT7 KRT8

Molecular functions related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.73 AR ESR1 PGR TP53
2 enzyme binding GO:0019899 9.71 AR ESR1 PGR TP53
3 ATPase binding GO:0051117 9.54 AR ESR1 PGR
4 scaffold protein binding GO:0097110 9.5 KRT15 KRT5 KRT8
5 steroid hormone receptor activity GO:0003707 9.43 AR ESR1 PGR
6 nuclear receptor activity GO:0004879 9.33 AR ESR1 PGR
7 steroid binding GO:0005496 9.13 AR ESR1 PGR
8 structural constituent of cytoskeleton GO:0005200 8.92 KRT14 KRT15 KRT20 KRT5

Sources for Sweat Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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