MCID: SWT003
MIFTS: 32

Sweat Gland Disease

Categories: Endocrine diseases, Skin diseases

Aliases & Classifications for Sweat Gland Disease

MalaCards integrated aliases for Sweat Gland Disease:

Name: Sweat Gland Disease 12 15 17
Sweat Gland Diseases 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1383
ICD9CM 34 705.9
MeSH 44 D013543
SNOMED-CT 67 88232005
ICD10 32 L74.9
UMLS 70 C0038986

Summaries for Sweat Gland Disease

Disease Ontology : 12 A skin disease located in the sweat glands.

MalaCards based summary : Sweat Gland Disease, also known as sweat gland diseases, is related to fox-fordyce disease and pompholyx, and has symptoms including pruritus, exanthema and increased sweating. An important gene associated with Sweat Gland Disease is PIP (Prolactin Induced Protein), and among its related pathways/superpathways are TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions and NF-kappa B signaling pathway. The drugs Liraglutide and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include sweat glands, and related phenotypes are integument and limbs/digits/tail

Wikipedia : 73 Sweat glands, also known as sudoriferous or sudoriparous glands, from Latin sudor 'sweat', are small... more...

Related Diseases for Sweat Gland Disease

Diseases related to Sweat Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 318)
# Related Disease Score Top Affiliating Genes
1 fox-fordyce disease 32.3 PIP CEACAM5
2 pompholyx 32.2 GLA EDAR EDA
3 miliaria 11.1
4 hidradenitis 11.1
5 ureter squamous cell carcinoma 10.5 KRT7 KRT5
6 anal canal paget's disease 10.5 PIP KRT7
7 gastric signet ring cell adenocarcinoma 10.5 PIP KRT7
8 leukoplakia of penis 10.5 KRT7 CEACAM5
9 inverted transitional papilloma 10.5 KRT7 KRT5
10 mucoepidermoid esophageal carcinoma 10.5 KRT5 CEACAM5
11 subareolar duct papillomatosis 10.5 KRT7 KRT5
12 nipple benign neoplasm 10.5 KRT7 KRT5
13 bartholin's gland carcinoma 10.5 PIP KRT7
14 mucinous adenofibroma 10.5 KRT7 CEACAM5
15 auditory system benign neoplasm 10.5 KRT7 KRT5
16 anus basaloid carcinoma 10.5 KRT7 CYLD
17 pancreatic foamy gland adenocarcinoma 10.5 KRT7 CEACAM5
18 vulvar eccrine porocarcinoma 10.5 PIP CEACAM5
19 microinvasive cervical squamous cell carcinoma 10.5 KRT7 KRT5
20 gallbladder squamous cell carcinoma 10.5 KRT5 CEACAM5
21 thymus adenocarcinoma 10.5 KRT5 CEACAM5
22 nodular hidradenoma 10.5 PIP CEACAM5
23 pancreatic serous cystadenocarcinoma 10.5 KRT7 CEACAM5
24 urinary bladder villous adenoma 10.5 KRT7 CEACAM5
25 eyelid carcinoma 10.5 PIP KRT7
26 vaginal tubulovillous adenoma 10.5 KRT7 CEACAM5
27 female urethral cancer 10.5 KRT7 CEACAM5
28 renal pelvis adenocarcinoma 10.5 KRT7 CEACAM5
29 bile duct cystadenocarcinoma 10.5 KRT7 CEACAM5
30 mucinous ovarian cystadenoma 10.5 KRT7 CEACAM5
31 lung clear cell carcinoma 10.5 KRT7 KRT5
32 rectosigmoid junction neoplasm 10.5 KRT7 CEACAM5
33 sarcomatoid basal cell carcinoma 10.5 KRT5 EWSR1
34 transverse colon cancer 10.5 KRT7 CEACAM5
35 sigmoid neoplasm 10.5 KRT7 CEACAM5
36 bartholin's duct cyst 10.5 PLAG1 PIP
37 krukenberg carcinoma 10.5 KRT7 CEACAM5
38 necrotizing sialometaplasia 10.5 KRT7 KRT5
39 ceruminoma 10.5 PIP KRT7 KRT5
40 anal canal squamous cell carcinoma 10.5 NCSTN KRT5
41 adenoid basal cell carcinoma 10.5 KRT7 CEACAM5
42 sensory organ benign neoplasm 10.5 KRT7 KRT5
43 colon leiomyosarcoma 10.5 KRT5 CEACAM5
44 appendiceal neoplasm 10.5 KRT7 CEACAM5
45 colonic lymphangioma 10.5 KRT7 CEACAM5
46 breast secretory carcinoma 10.5 SERPINA3 PIP KRT5
47 papillary adenoma 10.4 KRT7 KRT5 CEACAM5
48 vulvar syringoma 10.4 PIP PGR
49 papillary cystadenocarcinoma 10.4 SERPINA3 PIP KRT7
50 extraskeletal chondroma 10.4 SERPINA3 EWSR1

Graphical network of the top 20 diseases related to Sweat Gland Disease:



Diseases related to Sweat Gland Disease

Symptoms & Phenotypes for Sweat Gland Disease

UMLS symptoms related to Sweat Gland Disease:


pruritus; exanthema; increased sweating

MGI Mouse Phenotypes related to Sweat Gland Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.65 CYLD EDAR EDARADD ERBB2 KRT14 KRT5
2 limbs/digits/tail MP:0005371 9.23 CYLD EDAR EDARADD ERBB2 KRT5 NTRK1

Drugs & Therapeutics for Sweat Gland Disease

Drugs for Sweat Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Liraglutide Approved Phase 2 204656-20-2 44147092
2 Pharmaceutical Solutions Phase 2
3 Hormone Antagonists Phase 2
4 Incretins Phase 2
5 Hormones Phase 2
6 Hypoglycemic Agents Phase 2
7 Bromides Phase 2
8 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effects of Liraglutide on Sudomotor Function and Inflammation in Type 2 Diabetes Unknown status NCT03426085 Phase 2 Liraglutide 6 mg Solution for Injection
2 A Multicenter, Randomized, Double-Blinded, Vehicle-Controlled Study to Evaluate the Safety and Efficacy of 3 Concentrations of Topically Applied BBI-4000 (Sofpironium Bromide) Gel in Subjects With Axillary Hyperhidrosis Completed NCT03024255 Phase 2 BBI-4000 Concentration 1;BBI-4000 Concentration 2;BBI-4000 Concentration 3;Vehicle (Placebo)
3 Umbilical Cord Blood-derived Mesenchymal Stem Cells in Regeneration of Sweat Glands and Body Repair Unknown status NCT02304562 Phase 1
4 A Refined Minimally Invasive Procedure for Radical Treatment of Axillary Osmidrosis: Combined Tumescent Liposuction With Subcutaneous Pruning Through a Small Incision Unknown status NCT01539460
5 Management of Palmar Hyperhidrosis With Hydrogel-based Iontophoresis Completed NCT02854540

Search NIH Clinical Center for Sweat Gland Disease

Cochrane evidence based reviews: sweat gland diseases

Genetic Tests for Sweat Gland Disease

Anatomical Context for Sweat Gland Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Sweat Gland Disease:

19
Sweat Glands

Publications for Sweat Gland Disease

Articles related to Sweat Gland Disease:

# Title Authors PMID Year
1
Coloured sweat in two brothers: First report of familial chromhidrosis. 61
25753446 2016
2
[Surgical treatment of hidradenitis and Fox-Fordyce disease of the nipples]. 61
7872641 1994

Variations for Sweat Gland Disease

Expression for Sweat Gland Disease

Search GEO for disease gene expression data for Sweat Gland Disease.

Pathways for Sweat Gland Disease

Pathways related to Sweat Gland Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.05 EDARADD EDAR EDA
2 10.94 EDARADD EDAR EDA CYLD

GO Terms for Sweat Gland Disease

Cellular components related to Sweat Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 8.8 KRT7 KRT5 KRT14

Biological processes related to Sweat Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.55 PLAG1 PIP ERBB2 EDAR EDA
2 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
3 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.13 EDARADD EDAR EDA
4 salivary gland cavitation GO:0060662 8.62 EDAR EDA

Molecular functions related to Sweat Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.6 ZNF444 SIGLEC5 SERPINA3 PSTPIP1 PIP PGR

Sources for Sweat Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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