MCID: SWT004
MIFTS: 35

Sweat Gland Neoplasm

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sweat Gland Neoplasm

MalaCards integrated aliases for Sweat Gland Neoplasm:

Name: Sweat Gland Neoplasm 12 15 17
Tumor of the Sweat Gland 12
Neoplasm of Sweat Gland 12
Sweat Gland Neoplasms 44
Sweat Gland Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2664
MeSH 44 D013544
NCIt 50 C3398
SNOMED-CT 68 12933008
UMLS 72 C0038987

Summaries for Sweat Gland Neoplasm

MalaCards based summary : Sweat Gland Neoplasm, also known as tumor of the sweat gland, is related to hidradenoma and eccrine sweat gland neoplasm. An important gene associated with Sweat Gland Neoplasm is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs Talimogene laherparepvec and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and nk cells, and related phenotypes are Increased cell death HMECs cells and digestive/alimentary

Related Diseases for Sweat Gland Neoplasm

Diseases related to Sweat Gland Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 hidradenoma 33.3 MAML2 KRT7
2 eccrine sweat gland neoplasm 33.1 TP53 KRT7 KRT5 KRT10
3 apocrine sweat gland neoplasm 32.8 SOX10 KRT8 KRT7 KRT5 KRT14 CYLD
4 myoepithelioma 31.4 KRT18 KRT14 GFAP EWSR1
5 hidrocystoma 30.8 SOX10 KRT8 KRT7
6 eccrine adenocarcinoma 30.4 PIP KRT7
7 mucoepidermoid carcinoma 30.3 MAML2 KRT7 KRT14
8 soft tissue sarcoma 30.3 TP53 EWSR1
9 sweat gland cancer 30.3 TP53 KRT8 KRT7 KRT5 KRT18 KRT14
10 nodular hidradenoma 30.2 PIP KRT7 KRT10
11 malignant spiradenoma 30.1 TP53 KRT7 KRT5
12 spiradenoma 29.9 TP53 KRT7 KRT14 CYLD
13 hidradenocarcinoma 29.8 TP53 PIP KRT7 KRT5
14 adenosquamous carcinoma 29.6 TP53 KRT8 KRT7 KRT5
15 adenoid cystic carcinoma 29.1 TP53 SOX10 KRT7 KRT5 KRT14 CYLD
16 basal cell carcinoma 28.9 TP53 KRT8 KRT7 KRT10 CYLD
17 eccrine papillary adenoma 11.4
18 anus basaloid carcinoma 10.7 KRT7 CYLD
19 lichen planopilaris 10.6 KRT5 KRT14
20 vulvar sarcoma 10.6 KRT7 EWSR1
21 inverted transitional papilloma 10.6 KRT7 KRT5
22 epidermolysis bullosa simplex, autosomal recessive 1 10.6 KRT5 KRT14
23 balloon cell malignant melanoma 10.6 KRT7 KRT5
24 benign mesothelioma 10.6 KRT7 KRT5
25 middle ear adenoma 10.6 KRT7 KRT5
26 bile duct mucoepidermoid carcinoma 10.6 KRT7 KRT5
27 sensory organ benign neoplasm 10.6 KRT7 KRT5
28 epidermolysis bullosa simplex, localized 10.6 KRT5 KRT14
29 cutaneous mucoepidermoid carcinoma 10.6 MAML2 KRT7
30 epidermolysis bullosa simplex, generalized 10.6 KRT5 KRT14
31 parachordoma 10.6 KRT7 GFAP
32 endolymphatic sac tumor 10.5 KRT8 KRT7
33 adenoid squamous cell carcinoma 10.5 KRT8 KRT7
34 medulloepithelioma 10.5 KRT7 GFAP
35 nasal cavity cancer 10.5 KRT8 KRT7
36 peritoneum cancer 10.5 KRT7 KRT5
37 lung mucoepidermoid carcinoma 10.4 MAML2 KRT8
38 syringocystadenoma papilliferum 10.4
39 vesiculobullous skin disease 10.4 KRT5 KRT14
40 fibroepithelial basal cell carcinoma 10.4 TP53 KRT14
41 large intestine adenocarcinoma 10.4 PIP KRT7
42 adenoma 10.4
43 cystadenofibroma 10.4 KRT7 KRT5
44 frontal convexity meningioma 10.4 TP53 GFAP
45 gliofibroma 10.4 TP53 GFAP
46 benign breast adenomyoepithelioma 10.4 KRT7 KRT5 KRT14
47 breast adenomyoepithelioma 10.4 KRT7 KRT5 KRT14
48 keratinizing squamous cell carcinoma 10.4 TP53 KRT5
49 bladder carcinoma in situ 10.4 TP53 KRT7
50 vulval paget's disease 10.4 PIP KRT7

Graphical network of the top 20 diseases related to Sweat Gland Neoplasm:



Diseases related to Sweat Gland Neoplasm

Symptoms & Phenotypes for Sweat Gland Neoplasm

GenomeRNAi Phenotypes related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.1 CYLD EWSR1 KRT18 PIP SOX10 TP53

MGI Mouse Phenotypes related to Sweat Gland Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.23 CYLD GFAP KRT14 KRT5 KRT8 PIP

Drugs & Therapeutics for Sweat Gland Neoplasm

Drugs for Sweat Gland Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
2
nivolumab Approved Phase 2 946414-94-4
3 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors Suspended NCT02978625 Phase 2

Search NIH Clinical Center for Sweat Gland Neoplasm

Cochrane evidence based reviews: sweat gland neoplasms

Genetic Tests for Sweat Gland Neoplasm

Anatomical Context for Sweat Gland Neoplasm

MalaCards organs/tissues related to Sweat Gland Neoplasm:

41
Skin, T Cells, Nk Cells, Breast, Brain, Lymph Node

Publications for Sweat Gland Neoplasm

Articles related to Sweat Gland Neoplasm:

(show all 33)
# Title Authors PMID Year
1
Sonographic appearance of an eccrine spiradenoma: A case report. 38
29271484 2018
2
Primary Cutaneous Mucinous Carcinoma with Extramammary Paget's Disease: Eccrine or Apocrine? 38
29366305 2018
3
Hidradenocarcinoma: Five Years of Local and Systemic Control of a Rare Sweat Gland Neoplasm with Nodal Metastasis. 38
30155386 2018
4
Mammographic and ultrasound findings in poroid hidradenoma of the breast mimicking intraductal papilloma and papillary carcinoma: A case report. 38
29924021 2018
5
Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature. 38
27870729 2016
6
An unusual presentation of chondroid syringoma. 38
27510678 2016
7
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. 38
26288440 2015
8
Primary mucinous carcinoma of the skin: the Mayo Clinic experience over the past 2 decades. 38
25627628 2015
9
Combined melanocytic and sweat gland neoplasm: cell subsets harbor an identical HRAS mutation in phacomatosis pigmentokeratotica. 38
24628623 2014
10
Apocrine adenomyoepithelioma--a rare but distinctive primary sweat gland neoplasm. 38
22612240 2012
11
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature. 38
21809988 2011
12
Poroid hidradenoma in a child: an unusual presentation. 38
21276058 2011
13
Aggressive digital papillary adenocarcinoma diagnosed by fine needle aspiration cytology. 38
21187879 2010
14
Axillary apocrine carcinoma with Paget's disease and apocrine naevus. 38
19438526 2009
15
Mucinous carcinoma of the skin: evaluation of lymphatic invasion with D2-40. 38
18806501 2008
16
Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. 38
18182815 2008
17
'Nuclear grooves' in nodular hidradenoma: frequency and significance of an unrecognized histopatological feature. 38
17944729 2007
18
A rare and unusual case of bilateral, axillary, metachronous apocrine carcinoma. 38
18402127 2007
19
Papillary eccrine adenoma in association with cutaneous horn. 38
17492846 2007
20
Primary mucinous carcinoma with direct histopathologic evidence of lymphatic invasion. 38
16865872 2006
21
[Primary mucinous carcinoma of the skin. A case report]. 38
17127853 2006
22
Mohs micrographic surgery of a papillary eccrine adenoma. 38
12472500 2002
23
Aggressive digital papillary adenocarcinoma presenting as finger infection. 38
12351985 2002
24
Aberrant expression of p16 and RB protein in eccrine porocarcinoma. 38
12207741 2002
25
Apocrine gland carcinoma of the axilla: review of the literature and recommendations for treatment. 38
10199445 1999
26
Malignant chondroid syringoma. 38
9769603 1998
27
Mucinous syringometaplasia mimicked by a clear cell hidradenoma with mucinous change. 38
1662242 1991
28
Atypical chondroid syringoma. 38
1652102 1991
29
Papillary eccrine adenoma. A light microscopic and immunohistochemical study. 38
3290282 1988
30
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations. 38
3301927 1987
31
Primary mucinous carcinoma of the skin with metastases to the lymph nodes. 38
3004247 1985
32
Apocrine mixed tumour of the lid. 38
51494 1975
33
[Recurring brain metastases of a sweat gland neoplasm]. 38
4327568 1971

Variations for Sweat Gland Neoplasm

Expression for Sweat Gland Neoplasm

Search GEO for disease gene expression data for Sweat Gland Neoplasm.

Pathways for Sweat Gland Neoplasm

Pathways related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 KRT8 KRT7 KRT5 KRT18 KRT14 KRT10
2 12.04 KRT8 KRT7 KRT5 KRT18 KRT10
3
Show member pathways
11.89 KRT8 KRT7 KRT5 KRT18 KRT14 KRT10
4 11.35 TP53 KRT5 KRT14
5
Show member pathways
11.13 KRT8 KRT7 KRT5 KRT18 KRT14 GFAP
6 10.83 TP53 EWSR1

GO Terms for Sweat Gland Neoplasm

Cellular components related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 PIP KRT8 KRT7 KRT5 KRT18 KRT14
2 keratin filament GO:0045095 9.35 KRT8 KRT7 KRT5 KRT18 KRT14
3 cell periphery GO:0071944 9.33 KRT8 KRT18 KRT14
4 intermediate filament GO:0005882 9.17 KRT8 KRT7 KRT5 KRT18 KRT14 KRT10
5 cytoplasm GO:0005737 10.06 TP53 SOX10 KRT8 KRT7 KRT5 KRT18
6 nucleus GO:0005634 10 TP53 SOX10 PIP MAML2 KRT8 KRT7

Biological processes related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.62 TP53 KRT8 KRT7 KRT18
2 keratinization GO:0031424 9.43 KRT8 KRT7 KRT5 KRT18 KRT14 KRT10
3 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
4 hepatocyte apoptotic process GO:0097284 9.16 KRT8 KRT18
5 cornification GO:0070268 9.1 KRT8 KRT7 KRT5 KRT18 KRT14 KRT10

Molecular functions related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.33 KRT5 KRT14 GFAP
2 scaffold protein binding GO:0097110 9.13 KRT8 KRT5 KRT18
3 structural molecule activity GO:0005198 8.8 KRT18 KRT10 GFAP

Sources for Sweat Gland Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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