MCID: SWT004
MIFTS: 33

Sweat Gland Neoplasm

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sweat Gland Neoplasm

MalaCards integrated aliases for Sweat Gland Neoplasm:

Name: Sweat Gland Neoplasm 12 15 17
Tumor of the Sweat Gland 12
Neoplasm of Sweat Gland 12
Sweat Gland Neoplasms 43
Sweat Gland Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2664
MeSH 43 D013544
NCIt 49 C3398
SNOMED-CT 67 12933008
UMLS 71 C0038987

Summaries for Sweat Gland Neoplasm

MalaCards based summary : Sweat Gland Neoplasm, also known as tumor of the sweat gland, is related to eccrine sweat gland neoplasm and apocrine sweat gland neoplasm. An important gene associated with Sweat Gland Neoplasm is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Cytoskeleton remodeling Neurofilaments. The drugs nivolumab and Talimogene laherparepvec have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and liver, and related phenotypes are digestive/alimentary and immune system

Related Diseases for Sweat Gland Neoplasm

Diseases related to Sweat Gland Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 440)
# Related Disease Score Top Affiliating Genes
1 eccrine sweat gland neoplasm 33.2 PIP MME KRT7 KRT5 KRT14 CLEC2A
2 apocrine sweat gland neoplasm 33.1 PIP KRT8 KRT7 KRT5 KRT14 CYLD
3 eccrine papillary adenoma 32.5 PIP KRT8 KRT14 CEACAM5
4 myoepithelioma 31.5 ZNF444 SMARCB1 PLAG1 KRT14 GFAP EWSR1
5 sweat gland cancer 31.2 TP53 PIP KRT8 KRT7 KRT5 CLEC2A
6 nodular hidradenoma 31.1 PIP CLEC2A CEACAM5
7 eccrine porocarcinoma 31.1 KRT7 KRT5 CEACAM5
8 hidradenoma 30.9 PIP MME MAML2 KRT7 KRT5 CRTC1
9 apocrine adenoma 30.9 PIP KRT7 CEACAM5
10 mammary paget's disease 30.8 PIP KRT8 KRT7 KRT14
11 cystadenoma 30.8 MME KRT7 CEACAM5
12 fox-fordyce disease 30.7 PIP CEACAM5
13 hidrocystoma 30.7 PIP KRT8 KRT7 CLEC2A CEACAM5
14 malignant acrospiroma 30.6 MAML2 KRT5 CLEC2A CEACAM5
15 malignant syringoma 30.6 PIP KRT7 CLEC2A CEACAM5
16 eccrine adenocarcinoma 30.4 PIP KRT7 CYLD CEACAM5
17 apocrine adenocarcinoma 30.3 PIP KRT7 KRT5 KRT14
18 syringoma 30.3 KRT7 GFAP CLEC2A CEACAM5
19 cribriform carcinoma 30.2 PIP KRT8 KRT7 KRT5
20 skin benign neoplasm 30.2 KRT5 KRT14 CLEC2A CD34
21 soft tissue sarcoma 30.0 TP53 EWSR1
22 papillary adenocarcinoma 29.9 TP53 PIP KRT7 CEACAM5
23 signet ring cell adenocarcinoma 29.9 TP53 PIP KRT7 CEACAM5
24 neuroma 29.9 SMARCB1 GFAP CD34
25 sebaceous adenocarcinoma 29.8 TP53 PIP KRT5 KRT14
26 spiradenoma 29.7 TP53 KRT7 KRT14 CYLD CLEC2A
27 adenoid cystic carcinoma 29.7 TP53 PLAG1 KRT7 KRT5 KRT14 CYLD
28 malignant spiradenoma 29.7 TP53 KRT7 KRT5 CYLD CEACAM5
29 eccrine acrospiroma 29.4 TP53 PIP KRT7 KRT5 CLEC2A CEACAM5
30 meningioma, familial 29.3 TP53 SMARCB1 GFAP CD34
31 clear cell hidradenoma 28.8 PIP MME MAML2 KRT7 KRT5 CRTC1
32 basal cell carcinoma 28.3 TP53 MME KRT8 KRT7 KRT5 KRT14
33 adenosquamous carcinoma 28.2 TP53 MAML2 KRT8 KRT7 KRT5 CRTC1
34 mucoepidermoid carcinoma 28.1 TP53 MAML2 KRT7 KRT5 KRT14 EWSR1
35 anal canal paget's disease 10.6 PIP KRT7
36 anal gland adenocarcinoma 10.6 PIP KRT7
37 bartholin's gland adenocarcinoma 10.6 PIP KRT7
38 anus basaloid carcinoma 10.6 KRT7 CYLD
39 gastric signet ring cell adenocarcinoma 10.6 PIP KRT7
40 bartholin's gland carcinoma 10.6 PIP KRT7
41 urethral villous adenoma 10.6 KRT7 CEACAM5
42 seminal vesicle adenocarcinoma 10.6 KRT7 CEACAM5
43 vulvar syringoma 10.6 PIP CEACAM5
44 bartholin's gland disease 10.6 PIP KRT7
45 mucinous adenofibroma 10.6 KRT7 CEACAM5
46 vulvar eccrine porocarcinoma 10.6 PIP CEACAM5
47 inverted transitional papilloma 10.6 KRT7 KRT5
48 urinary bladder villous adenoma 10.6 KRT7 CEACAM5
49 sigmoid neoplasm 10.6 KRT7 CEACAM5
50 eyelid carcinoma 10.6 PIP KRT7

Graphical network of the top 20 diseases related to Sweat Gland Neoplasm:



Diseases related to Sweat Gland Neoplasm

Symptoms & Phenotypes for Sweat Gland Neoplasm

MGI Mouse Phenotypes related to Sweat Gland Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.61 CYLD GFAP KRT14 KRT5 KRT8 PBX1
2 immune system MP:0005387 9.36 CD34 CRTC1 CYLD GFAP KRT14 KRT8

Drugs & Therapeutics for Sweat Gland Neoplasm

Drugs for Sweat Gland Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
3 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors Suspended NCT02978625 Phase 2

Search NIH Clinical Center for Sweat Gland Neoplasm

Cochrane evidence based reviews: sweat gland neoplasms

Genetic Tests for Sweat Gland Neoplasm

Anatomical Context for Sweat Gland Neoplasm

MalaCards organs/tissues related to Sweat Gland Neoplasm:

40
Breast, Skin, Liver, Lung, Bone, Thymus, Colon

Publications for Sweat Gland Neoplasm

Articles related to Sweat Gland Neoplasm:

(show all 34)
# Title Authors PMID Year
1
Giant vascular eccrine spiradenoma presenting as a thrombosed varix. 61
31799485 2019
2
Sonographic appearance of an eccrine spiradenoma: A case report. 61
29271484 2018
3
Primary Cutaneous Mucinous Carcinoma with Extramammary Paget's Disease: Eccrine or Apocrine? 61
29366305 2018
4
Hidradenocarcinoma: Five Years of Local and Systemic Control of a Rare Sweat Gland Neoplasm with Nodal Metastasis. 61
30155386 2018
5
Mammographic and ultrasound findings in poroid hidradenoma of the breast mimicking intraductal papilloma and papillary carcinoma: A case report. 61
29924021 2018
6
Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature. 61
27870729 2016
7
An unusual presentation of chondroid syringoma. 61
27510678 2016
8
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. 61
26288440 2015
9
Primary mucinous carcinoma of the skin: the Mayo Clinic experience over the past 2 decades. 61
25627628 2015
10
Combined melanocytic and sweat gland neoplasm: cell subsets harbor an identical HRAS mutation in phacomatosis pigmentokeratotica. 61
24628623 2014
11
Apocrine adenomyoepithelioma--a rare but distinctive primary sweat gland neoplasm. 61
22612240 2012
12
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature. 61
21809988 2011
13
Poroid hidradenoma in a child: an unusual presentation. 61
21276058 2011
14
Aggressive digital papillary adenocarcinoma diagnosed by fine needle aspiration cytology. 61
21187879 2010
15
Axillary apocrine carcinoma with Paget's disease and apocrine naevus. 61
19438526 2009
16
Mucinous carcinoma of the skin: evaluation of lymphatic invasion with D2-40. 61
18806501 2008
17
Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. 61
18182815 2008
18
'Nuclear grooves' in nodular hidradenoma: frequency and significance of an unrecognized histopatological feature. 61
17944729 2007
19
A rare and unusual case of bilateral, axillary, metachronous apocrine carcinoma. 61
18402127 2007
20
Papillary eccrine adenoma in association with cutaneous horn. 61
17492846 2007
21
Primary mucinous carcinoma with direct histopathologic evidence of lymphatic invasion. 61
16865872 2006
22
[Primary mucinous carcinoma of the skin. A case report]. 61
17127853 2006
23
Mohs micrographic surgery of a papillary eccrine adenoma. 61
12472500 2002
24
Aggressive digital papillary adenocarcinoma presenting as finger infection. 61
12351985 2002
25
Aberrant expression of p16 and RB protein in eccrine porocarcinoma. 61
12207741 2002
26
Apocrine gland carcinoma of the axilla: review of the literature and recommendations for treatment. 61
10199445 1999
27
Malignant chondroid syringoma. 61
9769603 1998
28
Mucinous syringometaplasia mimicked by a clear cell hidradenoma with mucinous change. 61
1662242 1991
29
Atypical chondroid syringoma. 61
1652102 1991
30
Papillary eccrine adenoma. A light microscopic and immunohistochemical study. 61
3290282 1988
31
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations. 61
3301927 1987
32
Primary mucinous carcinoma of the skin with metastases to the lymph nodes. 61
3004247 1985
33
Apocrine mixed tumour of the lid. 61
51494 1975
34
[Recurring brain metastases of a sweat gland neoplasm]. 61
4327568 1971

Variations for Sweat Gland Neoplasm

Expression for Sweat Gland Neoplasm

Search GEO for disease gene expression data for Sweat Gland Neoplasm.

Pathways for Sweat Gland Neoplasm

Pathways related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.17 TP53 PBX1 KRT5 KRT14
2
Show member pathways
11.05 KRT8 KRT7 KRT5 KRT14 GFAP

GO Terms for Sweat Gland Neoplasm

Cellular components related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 9.33 KRT8 KRT14 CD34
2 keratin filament GO:0045095 9.26 KRT8 KRT7 KRT5 KRT14
3 intermediate filament GO:0005882 9.02 KRT8 KRT7 KRT5 KRT14 GFAP

Biological processes related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.55 TP53 SMARCB1 KRT8 KRT7 CRTC1
2 replicative senescence GO:0090399 9.32 TP53 MME
3 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
4 keratinization GO:0031424 9.26 KRT8 KRT7 KRT5 KRT14
5 cornification GO:0070268 8.92 KRT8 KRT7 KRT5 KRT14

Sources for Sweat Gland Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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