MCID: SWT004
MIFTS: 37

Sweat Gland Neoplasm

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sweat Gland Neoplasm

MalaCards integrated aliases for Sweat Gland Neoplasm:

Name: Sweat Gland Neoplasm 12 15 17
Tumor of the Sweat Gland 12
Neoplasm of Sweat Gland 12
Sweat Gland Neoplasms 45
Sweat Gland Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2664
MeSH 45 D013544
NCIt 51 C3398
SNOMED-CT 69 12933008
UMLS 74 C0038987

Summaries for Sweat Gland Neoplasm

MalaCards based summary : Sweat Gland Neoplasm, also known as tumor of the sweat gland, is related to eccrine sweat gland neoplasm and apocrine sweat gland neoplasm. An important gene associated with Sweat Gland Neoplasm is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs nivolumab and Talimogene laherparepvec have been mentioned in the context of this disorder. Affiliated tissues include skin, thymus and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Sweat Gland Neoplasm

Diseases related to Sweat Gland Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 eccrine sweat gland neoplasm 33.3 KRT15 KRT5 KRT7 TP53
2 apocrine sweat gland neoplasm 33.0 CYLD KRT14 KRT15 KRT5 KRT7 KRT8
3 hidradenoma 32.3 KRT7 MAML2
4 myoepithelioma 31.5 EWSR1 GFAP KRT14 SMARCB1
5 sweat gland cancer 31.1 KRT14 KRT15 KRT5 KRT7 KRT8 TP53
6 nodular hidradenoma 30.2 KRT7 PIP
7 hidradenocarcinoma 29.9 KRT5 KRT7 PIP TP53
8 eccrine papillary adenoma 11.3
9 acrospiroma 11.3
10 epidermolysis bullosa simplex, dowling-meara type 10.4 KRT14 KRT5
11 anus cancer 10.4 KRT5 KRT7
12 anus basaloid carcinoma 10.4 CYLD KRT7
13 lichen planopilaris 10.4 KRT14 KRT5
14 epidermolysis bullosa simplex, autosomal recessive 1 10.4 KRT14 KRT5
15 cervical adenosquamous carcinoma 10.4 KRT7 MAML2
16 inverted transitional papilloma 10.4 KRT5 KRT7
17 balloon cell malignant melanoma 10.4 KRT5 KRT7
18 benign mesothelioma 10.4 KRT5 KRT7
19 epidermolysis bullosa simplex, localized 10.4 KRT14 KRT5
20 immune system organ benign neoplasm 10.4 KRT7 KRT8
21 sensory organ benign neoplasm 10.4 KRT5 KRT7
22 bile duct mucoepidermoid carcinoma 10.4 KRT5 KRT7
23 middle ear adenoma 10.4 KRT5 KRT7
24 epidermolysis bullosa simplex, generalized 10.4 KRT14 KRT5
25 cutaneous mucoepidermoid carcinoma 10.4 KRT7 MAML2
26 sarcomatoid squamous cell skin carcinoma 10.4 KRT5 KRT8
27 parachordoma 10.4 GFAP KRT7
28 epidermolysis bullosa simplex with mottled pigmentation 10.4 KRT14 KRT5
29 proliferating trichilemmal cyst 10.3 KRT7 KRT8
30 endolymphatic sac tumor 10.3 KRT7 KRT8
31 esophageal basaloid squamous cell carcinoma 10.3 KRT14 TP53
32 malignant biphasic mesothelioma 10.3 KRT5 KRT7
33 adenoid squamous cell carcinoma 10.3 KRT7 KRT8
34 appendix cancer 10.3 KRT7 TP53
35 mixed cell type cancer 10.3 KRT7 TP53
36 granulosa cell tumor of the ovary 10.3 KRT7 TP53
37 malignant syringoma 10.3 KRT15 KRT7
38 medulloepithelioma 10.3 GFAP KRT7
39 optic nerve neoplasm 10.3 KRT5 TP53
40 nasal cavity cancer 10.3 KRT7 KRT8
41 central nervous system benign neoplasm 10.3 GFAP TP53
42 peritoneum cancer 10.3 KRT5 KRT7
43 lung mucoepidermoid carcinoma 10.3 KRT8 MAML2
44 schneiderian carcinoma 10.3 KRT5 MAML2
45 gastric squamous cell carcinoma 10.3 KRT5 KRT7
46 fibroepithelial basal cell carcinoma 10.3 KRT14 TP53
47 vulvar intraepithelial neoplasia 10.3 KRT7 TP53
48 apocrine adenocarcinoma 10.3 KRT15 KRT5
49 warthin tumor 10.3 KRT7 MAML2
50 benign breast adenomyoepithelioma 10.3 KRT14 KRT5 KRT7

Graphical network of the top 20 diseases related to Sweat Gland Neoplasm:



Diseases related to Sweat Gland Neoplasm

Symptoms & Phenotypes for Sweat Gland Neoplasm

GenomeRNAi Phenotypes related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.77 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.77 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.77 KRT5 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.77 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.77 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.77 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.77 KRT5 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.77 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.77 KRT5 KRT7
10 Increased proliferation GR00094-A 8.62 SMARCB1 TP53

MGI Mouse Phenotypes related to Sweat Gland Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 CYLD GFAP KRT14 KRT7 PBX1 PIP
2 digestive/alimentary MP:0005381 9.85 CYLD GFAP KRT14 KRT15 KRT5 KRT8
3 homeostasis/metabolism MP:0005376 9.61 CYLD GFAP KRT14 KRT15 KRT7 KRT8
4 immune system MP:0005387 9.23 CYLD GFAP KRT14 KRT8 PBX1 PIP

Drugs & Therapeutics for Sweat Gland Neoplasm

Drugs for Sweat Gland Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
3 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Sweat Gland Neoplasm

Cochrane evidence based reviews: sweat gland neoplasms

Genetic Tests for Sweat Gland Neoplasm

Anatomical Context for Sweat Gland Neoplasm

MalaCards organs/tissues related to Sweat Gland Neoplasm:

42
Skin, Thymus, Kidney, Ovary, Spinal Cord, Prostate, Tonsil

Publications for Sweat Gland Neoplasm

Articles related to Sweat Gland Neoplasm:

# Title Authors Year
1
Hidradenocarcinoma: Five Years of Local and Systemic Control of a Rare Sweat Gland Neoplasm with Nodal Metastasis. ( 30155386 )
2018
2
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. ( 26288440 )
2015
3
Combined melanocytic and sweat gland neoplasm: cell subsets harbor an identical HRAS mutation in phacomatosis pigmentokeratotica. ( 24628623 )
2014
4
Apocrine adenomyoepithelioma--a rare but distinctive primary sweat gland neoplasm. ( 22612240 )
2012

Variations for Sweat Gland Neoplasm

Expression for Sweat Gland Neoplasm

Search GEO for disease gene expression data for Sweat Gland Neoplasm.

Pathways for Sweat Gland Neoplasm

Pathways related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 KRT14 KRT15 KRT5 KRT7 KRT8 PBX1
2
Show member pathways
12.01 KRT14 KRT15 KRT5 KRT7 KRT8
3 11.81 EWSR1 PBX1 TP53
4 11.17 KRT14 KRT5 PBX1 TP53
5
Show member pathways
11.05 GFAP KRT14 KRT5 KRT7 KRT8
6 10.78 EWSR1 TP53

GO Terms for Sweat Gland Neoplasm

Cellular components related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.9 EWSR1 KRT14 KRT15 KRT5 KRT7 KRT8
2 keratin filament GO:0045095 9.26 KRT14 KRT5 KRT7 KRT8
3 intermediate filament GO:0005882 9.1 GFAP KRT14 KRT15 KRT5 KRT7 KRT8

Biological processes related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.67 KRT7 KRT8 SMARCB1 TP53
2 epidermis development GO:0008544 9.43 KRT14 KRT15 KRT5
3 keratinization GO:0031424 9.35 KRT14 KRT15 KRT5 KRT7 KRT8
4 positive regulation of transcription of Notch receptor target GO:0007221 9.32 MAML2 PBX1
5 hemidesmosome assembly GO:0031581 9.16 KRT14 KRT5
6 cornification GO:0070268 9.02 KRT14 KRT15 KRT5 KRT7 KRT8

Molecular functions related to Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 CYLD EWSR1 GFAP KRT14 KRT15 KRT5
2 scaffold protein binding GO:0097110 9.13 KRT15 KRT5 KRT8
3 structural constituent of cytoskeleton GO:0005200 8.92 GFAP KRT14 KRT15 KRT5

Sources for Sweat Gland Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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