MCID: SWN001
MIFTS: 45

Swine Influenza

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Swine Influenza

MalaCards integrated aliases for Swine Influenza:

Name: Swine Influenza 12 73 54 3 15 17 70
Influenza Due to Influenza a Virus Subtype H1n1 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050211
UMLS 70 C0276357 C2076600

Summaries for Swine Influenza

CDC : 3 Swine influenza is a respiratory disease of pigs caused by type A influenza viruses that regularly cause outbreaks of influenza in pigs. Influenza viruses that commonly circulate in swine are called "swine influenza viruses" or "swine flu viruses." Like human influenza viruses, there are different subtypes and strains of swine influenza viruses. The main swine influenza viruses circulating in U.S. pigs in recent years have been, swine triple reassortant (tr) H1N1 influenza virus, trH3N2 virus, and trH1N2 virus.

MalaCards based summary : Swine Influenza, also known as influenza due to influenza a virus subtype h1n1, is related to avian influenza and bacterial pneumonia, and has symptoms including vomiting, fever and lethargy. An important gene associated with Swine Influenza is NEU1 (Neuraminidase 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Zanamivir and Oseltamivir have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract of pigs, skin and lung, and related phenotype is immune system.

Disease Ontology : 12 An influenza that results in infection located in respiratory tract of pigs and humans, has material basis in Influenza C virus, or has material basis in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted by direct contact with infected pigs. The infection in humans has symptom fever, has symptom lethargy, has symptom lack of appetite, has symptom coughing, has symptom runny nose, has symptom sore throat, has symptom nausea, has symptom vomiting, and has symptom diarrhea.

Wikipedia : 73 Swine influenza is an infection caused by any one of several types of swine influenza viruses. Swine... more...

Related Diseases for Swine Influenza

Diseases related to Swine Influenza via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 305)
# Related Disease Score Top Affiliating Genes
1 avian influenza 31.4 TNF NEU1 IFNA1 DDX58
2 bacterial pneumonia 30.7 TNF NEU1 CD8A CD4
3 disease by infectious agent 30.5 TNF IFNB1 IFNA1 CD8A CD4
4 influenza 30.4 TRIM25 TNF NEU1 MX1 IRF3 IFNB1
5 variola major 30.2 CD8A CD4
6 mouth disease 30.2 MX1 IRF3 IFNA1 DDX58
7 rubella 30.2 TNF IFNB1 DDX58
8 bacterial infectious disease 30.2 TNF MX1 IFNB1 CD4
9 bronchopneumonia 30.1 TNF CD8A CD4
10 parainfluenza virus type 3 30.1 NEU1 IFNB1 IFNA1 DDX58
11 mumps 30.0 TNF MX1 IFNB1 IFNA1
12 measles 30.0 TNF IRF3 IFNB1 IFNA1 DDX58
13 respiratory failure 30.0 TNF NEU1 CD8A CD4
14 plague 30.0 TNF DDX58 CD8A CD4
15 rabies 30.0 MX1 IRF3 IFNA1 DDX58
16 newcastle disease 30.0 TNF NEU1 IRF3 IFNB1 IFNA1 DDX58
17 encephalitis 30.0 TNF IRF3 IFNB1 DDX58
18 vaccinia 29.9 TNF IRF3 IFNB1 IFNA1
19 japanese encephalitis 29.8 TNF IRF3 IFNB1 IFNA1 DDX58
20 viral pneumonia 29.8 TNF IFNB1 IFITM3 DDX58 CD8A CD4
21 demyelinating disease 29.8 TNF IFNB1 IFNA1 CD8A CD4
22 pneumonia 10.5
23 haemophilus influenzae 10.5
24 lymphopenia 10.4
25 oral erosive lichen 10.4 IFNB1 IFNA1
26 null-cell leukemia 10.4 TNF IFNA1
27 bolivian hemorrhagic fever 10.4 GP2 DDX58
28 guillain-barre syndrome 10.4
29 toxicodendron dermatitis 10.4 TNF CD8A
30 respiratory syncytial virus infectious disease 10.4 NEU1 IFNB1
31 argentine hemorrhagic fever 10.3 IFNA1 GP2 DDX58
32 wissler-fanconi syndrome 10.3 IFNA1 CD4
33 rheumatoid arthritis interstitial lung disease 10.3 TNF CD4
34 cork-handlers' disease 10.3 CD8A CD4
35 necrotic uveal melanoma 10.3 CD8A CD4
36 early yaws 10.3 CD8A CD4
37 marburg hemorrhagic fever 10.3 IFNA1 GP2 CD8A
38 meningovascular neurosyphilis 10.3 TNF CD4
39 tracheitis 10.3 TNF CD8A
40 ventilation pneumonitis 10.3 CD8A CD4
41 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
42 latent syphilis 10.3 CD8A CD4
43 opportunistic bacterial infectious disease 10.3 TNF CD4
44 subacute sclerosing panencephalitis 10.3 TNF MX1 IFNA1
45 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
46 cutaneous lupus erythematosus 10.3 TNF MX1 IFNA1
47 adult dermatomyositis 10.3 TNF IFNA1
48 nocardiosis 10.3 TNF CD4
49 tick-borne encephalitis 10.3 IFNB1 IFNA1 DDX58
50 arachnoiditis 10.3 TNF CD4

Graphical network of the top 20 diseases related to Swine Influenza:



Diseases related to Swine Influenza

Symptoms & Phenotypes for Swine Influenza

Symptoms:

12
  • vomiting
  • fever
  • lethargy
  • diarrhea
  • nausea
  • sore throat
  • coughing
  • lack of appetite
  • runny nose

UMLS symptoms related to Swine Influenza:


fever; pruritus; snoring; coughing

MGI Mouse Phenotypes related to Swine Influenza:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 CD4 CD8A DDX58 IFITM3 IFNB1 IRF3

Drugs & Therapeutics for Swine Influenza

Drugs for Swine Influenza (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zanamivir Approved, Investigational Phase 3 139110-80-8 60855
2
Oseltamivir Approved Phase 3 196618-13-0, 204255-11-8 65028
3 Anti-Infective Agents Phase 3
4 Antiviral Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicentre, Randomized, Controlled Clinical Trial Comparing Oseltamivir With Placebo And Zanamivir With Control As The First Line Treatment For Human Swine Influenza (H1N1) Infection In Designated Flu Clinics During The Pandemic Influenza in Hong Kong Terminated NCT00979667 Phase 3 Oseltamivir;Zanamivir;Placebo of Oseltamivir

Search NIH Clinical Center for Swine Influenza

Genetic Tests for Swine Influenza

Anatomical Context for Swine Influenza

The Foundational Model of Anatomy Ontology organs/tissues related to Swine Influenza:

19
Respiratory Tract Of Pigs

MalaCards organs/tissues related to Swine Influenza:

40
Skin, Lung, Lymph Node, T Cells, Endothelial, Trachea, Spinal Cord

Publications for Swine Influenza

Articles related to Swine Influenza:

(show top 50) (show all 1755)
# Title Authors PMID Year
1
[Rescue of H3N2 subtype swine influenza virus and substitution of hemagglutinin, neuraminidase]. 61 54
19673419 2009
2
[Origin of hemagglutinin and neuraminidase gene of swine influenza A H1N1 viruses]. 61 54
15340540 2003
3
Comparison of the pathogenesis of two genetically different H3N2 influenza A viruses in pigs. 61 54
12734230 2003
4
Complete sequences of the neuraminidase genes of swine influenza viruses (H1N1) associated with the respiratory disease in pigs. 61 54
9311570 1997
5
Large outbreak of swine influenza in southern Japan caused by reassortant (H1N2) influenza viruses: its epizootic background and characterization of the causative viruses. 61 54
8760422 1996
6
The matrix gene of pdm/09 H1N1 contributes to the pathogenicity and transmissibility of SIV in mammals. 61
33740730 2021
7
Bat influenza vectored NS1-truncated live vaccine protects pigs against heterologous virus challenge. 61
33715905 2021
8
Administration of a CXC Chemokine Receptor 2 (CXCR2) Antagonist, SCH527123, Together with Oseltamivir Suppresses NETosis and Protects Mice from Lethal Influenza and Piglets from Swine-Influenza Infection. 61
33453177 2021
9
Variation in the HA antigenicity of A(H1N1)pdm09-related swine influenza viruses. 61
33616517 2021
10
Human Infection with Eurasian Avian-Like Swine Influenza A(H1N1) Virus, the Netherlands, September 2019. 61
33622472 2021
11
[Cross-reaction of seasonal influenza vaccine immune serum against Eurasian Avian-like H1N1 swine influenza virus]. 61
33663187 2021
12
Swine Influenza A Viruses and the Tangled Relationship with Humans. 61
31988203 2021
13
Implementation of next-generation sequencing for virus identification in veterinary diagnostic laboratories. 61
33357110 2021
14
Infection and risk factors of human and avian influenza in pigs in south China. 61
33744674 2021
15
Development of a swine RNA polymerase I driven Influenza reverse genetics system for the rescue of type A and B Influenza viruses. 61
33152409 2021
16
A bivalent live attenuated influenza virus vaccine protects against H1N2 and H3N2 viral infection in swine. 61
33418392 2021
17
Ser-Leu substitution at P2 position of the hemagglutinin cleavage site attenuates replication and pathogenicity of Eurasian avian-like H1N2 swine influenza viruses. 61
33360319 2021
18
Detection of swine influenza virus in nasal specimens by reverse transcription-loop-mediated isothermal amplification (RT-LAMP). 61
33271254 2021
19
Epidemiology and Genotypic Diversity of Eurasian Avian-Like H1N1 Swine Influenza Viruses in China. 61
32638231 2021
20
Characterization of contemporary 2010.1 H3N2 swine influenza A viruses circulating in United States pigs. 61
33253936 2021
21
Occupations at risk of contracting zoonoses of public health significance in Québec. 61
33679248 2021
22
Vaccines That Reduce Viral Shedding Do Not Prevent Transmission of H1N1 Pandemic 2009 Swine Influenza A Virus Infection to Unvaccinated Pigs. 61
33268518 2021
23
Respiratory viral infections drive different lung cytokine profiles in pigs. 61
33407470 2021
24
Immunity and Protective Efficacy of Mannose Conjugated Chitosan-Based Influenza Nanovaccine in Maternal Antibody Positive Pigs. 61
33746943 2021
25
Associations between animal and herd management factors, serological response to three respiratory pathogens and pluck lesions in finisher pigs on a farrow-to-finish farm. 61
33292673 2020
26
Detection and Characterization of Swine Origin Influenza A(H1N1) Pandemic 2009 Viruses in Humans following Zoonotic Transmission. 61
33115872 2020
27
Molecular epidemiology and glycomics of swine influenza viruses circulating in commercial swine farms in the southeastern and midwest United States. 61
33181438 2020
28
The role of PA-X C-terminal 20 residues of classical swine influenza virus in its replication and pathogenicity. 61
33197868 2020
29
A Century of Swine Influenza: Is It Really Just about the Pigs? 61
33256019 2020
30
H9N2 swine influenza virus infection-induced damage is mediated by TRPM2 channels in mouse pulmonary microvascular endothelial cells. 61
32707310 2020
31
Persistence of pdm2009-H1N1 internal genes of swine influenza in pigs, Thailand. 61
33199784 2020
32
Distribution and evolution of H1N1 influenza A viruses with adamantanes-resistant mutations worldwide from 1918 to 2019. 61
33200496 2020
33
Genetic and Antigenic Evolution of European Swine Influenza A Viruses of HA-1C (Avian-Like) and HA-1B (Human-Like) Lineages in France from 2000 to 2018. 61
33202972 2020
34
Swine influenza viruses and pandemic H1N1-2009 infection in pigs, Myanmar. 61
32385913 2020
35
Primary Swine Respiratory Epithelial Cell Lines for the Efficient Isolation and Propagation of Influenza A Viruses. 61
32967961 2020
36
A chimeric influenza hemagglutinin delivered by parainfluenza virus 5 vector induces broadly protective immunity against genetically divergent influenza a H1 viruses in swine. 61
33039727 2020
37
Swine MicroRNAs ssc-miR-221-3p and ssc-miR-222 Restrict the Cross-Species Infection of Avian Influenza Virus. 61
32907982 2020
38
Environment-, health-, performance- and welfare-related parameters in pig barns with natural and mechanical ventilation. 61
32971371 2020
39
Evaluation of the Pathogenicity and the Escape from Vaccine Protection of a New Antigenic Variant Derived from the European Human-Like Reassortant Swine H1N2 Influenza Virus. 61
33053905 2020
40
Swine influenza virus: Current status and challenge. 61
32798539 2020
41
Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses. 61
32721380 2020
42
Co-infection status of novel parvovirus's (PPV2 to 4) with porcine circovirus 2 in porcine respiratory disease complex and porcine circovirus-associated disease from 1997 to 2012. 61
32969579 2020
43
Correction to Supporting Information for Sun et al., Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection. 61
32900961 2020
44
Porcine Reproductive and Respiratory Syndrome Virus Interferes with Swine Influenza A Virus Infection of Epithelial Cells. 61
32899579 2020
45
Infection Dynamics of Swine Influenza Virus in a Danish Pig Herd Reveals Recurrent Infections with Different Variants of the H1N2 Swine Influenza A Virus Subtype. 61
32927910 2020
46
Risk of zoonotic transmission of swine influenza at the human-pig interface in Guangdong Province, China. 61
32506781 2020
47
Detection of H1 Swine Influenza A Virus Antibodies in Human Serum Samples by Age Group1. 61
32818398 2020
48
Evaluation of two multiplex RT-PCR assays for detection and subtype differentiation of Brazilian swine influenza viruses. 61
32125678 2020
49
Dynamic behavior of swine influenza transmission during the breed-slaughter process. 61
33120579 2020
50
Kinetics of single and dual simultaneous infection of pigs with swine influenza A virus and porcine reproductive and respiratory syndrome virus. 61
32618394 2020

Variations for Swine Influenza

Expression for Swine Influenza

Search GEO for disease gene expression data for Swine Influenza.

Pathways for Swine Influenza

Pathways related to Swine Influenza according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 TRIM25 TNF NEU1 MX1 IRF3 IFNB1
2
Show member pathways
13.13 TRIM25 TNF MX1 IRF3 IFNB1 IFNA17
3
Show member pathways
13.1 TNF MX1 IRF3 IFNB1 IFNA17 IFNA1
4
Show member pathways
12.91 TNF MX1 IRF3 IFNB1 IFNA17 IFNA1
5
Show member pathways
12.84 TNF IRF3 IFNB1 IFNA17 IFNA1 CD4
6
Show member pathways
12.76 TNF IFNA17 IFNA1 CD8A CD4
7 12.7 TNF IRF3 IFNB1 IFNA17 IFNA1 DDX58
8 12.42 TRIM25 TNF IRF3 IFNA1 DDX58 CD8A
9
Show member pathways
12.41 TNF IFNB1 IFNA17 IFNA1
10
Show member pathways
12.39 TRIM25 IRF3 IFNB1 IFNA17 IFNA1 DDX58
11
Show member pathways
12.32 TRIM25 TNF MX1 IRF3 IFNB1 IFNA17
12
Show member pathways
12.31 TNF IRF3 IFNB1 IFNA17 IFNA1
13
Show member pathways
12.2 TRIM25 TNF IRF3 IFNB1 IFNA17 IFNA1
14 12.16 TNF IFNB1 IFNA17 IFNA1
15
Show member pathways
12.12 TNF IFNB1 IFNA17 IFNA1
16 12.11 TNF IRF3 IFNB1 IFNA17 IFNA1
17 12.07 IRF3 IFNB1 IFNA17 IFNA1
18
Show member pathways
12.01 TNF MX1 IRF3 IFNB1 IFNA17 IFNA1
19 11.9 TNF IRF3 IFNB1 CD8A CD4
20 11.83 TRIM25 TNF DDX58
21 11.8 TNF CD8A CD4
22 11.76 IFNB1 IFNA17 IFNA1
23
Show member pathways
11.72 TRIM25 MX1 IRF3 IFNB1 IFNA17 IFNA1
24 11.69 TNF CD8A CD4
25 11.65 TNF IFNB1 CD8A CD4
26 11.43 IFNB1 IFNA17 IFNA1
27 11.17 TNF IFNB1 CD4
28
Show member pathways
11.03 MX1 IRF3 DDX58

GO Terms for Swine Influenza

Biological processes related to Swine Influenza according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.05 TRIM25 MX1 IRF3 IFITM3 DDX58 CD8A
2 viral process GO:0016032 9.99 TRIM25 IRF3 DDX58 CPSF4 CD4
3 adaptive immune response GO:0002250 9.97 IFNB1 IFNA17 IFNA1 CD8A CD4
4 cytokine-mediated signaling pathway GO:0019221 9.93 TNF IFNB1 IFNA17 IFNA1 CD4
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.86 TRIM25 TNF IRF3 CD4
6 defense response GO:0006952 9.8 TNF MX1 IFNB1 IFNA17 IFNA1
7 B cell differentiation GO:0030183 9.76 IFNB1 IFNA17 IFNA1
8 response to virus GO:0009615 9.73 TNF MX1 IFNB1 IFNA17 IFITM3 DDX58
9 B cell proliferation GO:0042100 9.72 IFNB1 IFNA17 IFNA1
10 humoral immune response GO:0006959 9.72 TNF ST6GAL1 IFNB1 IFNA17 IFNA1
11 negative regulation of type I interferon production GO:0032480 9.7 TRIM25 IRF3 DDX58
12 T cell activation involved in immune response GO:0002286 9.67 IFNB1 IFNA17 IFNA1
13 negative regulation of viral genome replication GO:0045071 9.67 TNF MX1 IFNB1 IFITM3
14 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.65 IFNB1 IFNA17 IFNA1
15 cellular response to exogenous dsRNA GO:0071360 9.63 IRF3 IFNB1 DDX58
16 natural killer cell activation involved in immune response GO:0002323 9.61 IFNB1 IFNA17 IFNA1
17 RIG-I signaling pathway GO:0039529 9.57 TRIM25 DDX58
18 response to exogenous dsRNA GO:0043330 9.55 IRF3 IFNB1 IFNA17 IFNA1 DDX58
19 type I interferon signaling pathway GO:0060337 9.43 MX1 IRF3 IFNB1 IFNA17 IFNA1 IFITM3
20 defense response to virus GO:0051607 9.23 TRIM25 MX1 IRF3 IFNB1 IFNA17 IFNA1

Molecular functions related to Swine Influenza according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 TNF IFNB1 IFNA17 IFNA1
2 cytokine receptor binding GO:0005126 9.13 IFNB1 IFNA17 IFNA1
3 type I interferon receptor binding GO:0005132 8.8 IFNB1 IFNA17 IFNA1

Sources for Swine Influenza

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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