MCID: SWN001
MIFTS: 45

Swine Influenza

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Swine Influenza

Summaries for Swine Influenza

CDC : 3 Swine influenza is a respiratory disease of pigs caused by type A influenza viruses that regularly cause outbreaks of influenza in pigs. Influenza viruses that commonly circulate in swine are called “swine influenza viruses” or “swine flu viruses.” Like human influenza viruses, there are different subtypes and strains of swine influenza viruses. The main swine influenza viruses circulating in U.S. pigs in recent years have been, swine triple reassortant (tr) H1N1 influenza virus, trH3N2 virus, and trH1N2 virus.

MalaCards based summary : Swine Influenza, also known as influenza due to influenza a virus subtype h1n1, is related to avian influenza and influenza, and has symptoms including fever, vomiting and diarrhea. An important gene associated with Swine Influenza is TNF (Tumor Necrosis Factor). The drugs Vitamin C and Vitamin A have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and t cells.

Disease Ontology : 12 An influenza that results in infection located in respiratory tract of pigs and humans, has material basis in Influenza C virus, or has material basis in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted by direct contact with infected pigs. The infection in humans has symptom fever, has symptom lethargy, has symptom lack of appetite, has symptom coughing, has symptom runny nose, has symptom sore throat, has symptom nausea, has symptom vomiting, and has symptom diarrhea.

Wikipedia : 77 Swine influenza is an infection caused by any one of several types of swine influenza viruses. Swine... more...

Related Diseases for Swine Influenza

Graphical network of the top 20 diseases related to Swine Influenza:



Diseases related to Swine Influenza

Symptoms & Phenotypes for Swine Influenza

Symptoms:

12
  • fever
  • vomiting
  • diarrhea
  • lethargy
  • nausea
  • sore throat
  • coughing
  • lack of appetite
  • runny nose

UMLS symptoms related to Swine Influenza:


fever, pruritus, snoring, coughing

Drugs & Therapeutics for Swine Influenza

Drugs for Swine Influenza (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
2
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
3
Lactitol Investigational Phase 4,Phase 2,Not Applicable 585-88-6, 585-86-4 493591
4 Vitamins Phase 4
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
6 Trace Elements Phase 4
7 Antipyretics Phase 4
8 Antiviral Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 retinol Phase 4
10 Nutrients Phase 4
11 Antioxidants Phase 4
12 Retinol palmitate Phase 4
13 Micronutrients Phase 4
14 Protective Agents Phase 4
15 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
16 Vaccines Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
17 Antibodies Phase 4,Phase 2,Phase 1,Not Applicable
18 Immunoglobulins Phase 4,Phase 2,Phase 1,Not Applicable
19 MF59 oil emulsion Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
20 Immunosuppressive Agents Phase 4
21 Hemagglutinins Phase 4,Phase 2,Phase 1
22
Zanamivir Approved, Investigational Phase 3,Phase 2 139110-80-8 60855
23
Oseltamivir Approved Phase 3,Phase 2,Not Applicable 204255-11-8, 196618-13-0 65028
24
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
25
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
26 Adjuvants, Immunologic Phase 2, Phase 3,Phase 3,Not Applicable
27 Anti-Inflammatory Agents Phase 3,Phase 2
28 Hydrocortisone-17-butyrate Phase 3
29 Hydrocortisone hemisuccinate Phase 3
30 Hydrocortisone 17-butyrate 21-propionate Phase 3
31
Calcium Approved, Nutraceutical Phase 2,Not Applicable 7440-70-2 271
32
Thymalfasin Investigational Phase 2 62304-98-7
33 Antibodies, Monoclonal Phase 2
34 Pharmaceutical Solutions Phase 2,Phase 1
35 Agglutinins Phase 1, Phase 2
36 Anti-Bacterial Agents Phase 2
37 Antibiotics, Antitubercular Phase 2
38 Immunoglobulins, Intravenous Phase 2
39 Rho(D) Immune Globulin Phase 2
40 gamma-Globulins Phase 2
41 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2,Not Applicable
42 Antimetabolites Phase 2,Not Applicable
43 Anticholesteremic Agents Phase 2,Not Applicable
44 Hypolipidemic Agents Phase 2,Not Applicable
45 Lipid Regulating Agents Phase 2,Not Applicable
46 MEDI8852 Phase 2
47 Rosuvastatin Calcium Phase 2,Not Applicable 147098-20-2
48 Calcium, Dietary Phase 2,Not Applicable
49
Formaldehyde Approved, Vet_approved Phase 1 50-00-0 712
50
Aluminum sulfate Approved Phase 1 10043-01-3

Interventional clinical trials:

(show top 50) (show all 160)
# Name Status NCT ID Phase Drugs
1 The Impact of Vitamin on the Clinical Course in Cases Infected by Novel H1N1 Influenza Virus A Unknown status NCT01127282 Phase 4 Vitamin (vitamin A 15 mg,C 500 mg, E 400IU);Placebo (digestive tablet)
2 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
3 Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients Unknown status NCT01017172 Phase 4
4 Open-label, Uncontrolled Postmarketing Study of Cell-derived A/H1N1 Influenza HA Vaccine in Japanese Elderly Subjects Completed NCT01069367 Phase 4
5 H1N1 Influenza Vaccine Immunogenicity in HIV-1 Infected Patients Completed NCT01111162 Phase 4
6 A Clinical Trial of Split-virion Influenza A/H1N1 Vaccines Completed NCT01004653 Phase 4
7 Sinovac, H1N1 Vaccine + Trivalent Inactivated Influenza Vaccine, Adults Completed NCT01008137 Phase 4
8 Rapid Evaluation of Pandemic H1N1 Influenza Vaccine in Adults With HIV Completed NCT01002040 Phase 4
9 Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients Completed NCT01022905 Phase 4
10 Safety of H1N1 Influenza Vaccination in Pregnant Women Completed NCT01842997 Phase 4
11 Rapid Evaluation of Pandemic H1N1 Influenza Vaccines in Young Children Completed NCT01000831 Phase 4
12 Rapid Evaluation of Pandemic H1N1 Influenza Vaccine in Aboriginal Children and Adults Completed NCT01001026 Phase 4
13 Rapid Evaluation of Pandemic H1N1 Influenza Vaccine in Adults Receiving Seasonal Influenza Vaccine Completed NCT01000584 Phase 4
14 Clinical Study to Evaluate Antibody and Cell Mediated Immunity of A/H1N1 Influenza Vaccine in Healthy Subjects Completed NCT01079273 Phase 4
15 Vaccination Against Influenza in Autoimmune Diseases Completed NCT01065285 Phase 4
16 Phase IV Clinical Trial of an Influenza Split Vaccine Anflu Completed NCT00556062 Phase 4
17 Infectivity, Replication & Immunogenicity of Live nH1N1 Vaccine Completed NCT01023776 Phase 4
18 A Study to Evaluate the Safety of H1N1 Monovalent Vaccine (MEDI3414) in Healthy Adults Completed NCT00945893 Phase 4
19 A Study to Evaluate the Safety of HIN1 Monovalent Vaccine (MEDI3414) in Children 2 to 17 Years of Age Completed NCT00946101 Phase 4
20 Study of GSK Biologicals' Influenza Vaccine Arepanrix™ in Japanese Adults 65 Years of Age or Older Completed NCT01114620 Phase 4
21 A Study to Assess Immunogenicity Parameters After Vaccination Against Influenza and to Evaluate How These Parameters Change During the Influenza Season Completed NCT01457027 Phase 4
22 Direct and Indirect Protection by Influenza Vaccine Given to Children in India Completed NCT00934245 Phase 4
23 Effect of Age and Prior Immunity on Response to H1N1 Vaccines in Children Withdrawn NCT01097941 Phase 4
24 Assessment of Needle-free Disposable-syringe Jet Injector (DSJI) ID Dose-sparing of Pandemic A H1N1 Influenza Vaccine Unknown status NCT01582633 Phase 2, Phase 3
25 Novel Influenza A/H1N1 Split- Virion Vaccine in Healthy Children Aged 6 to 35 Month Unknown status NCT01040078 Phase 3
26 Single-blind, Dose-ranging Study of Novel Swine Influenza Virus Vaccine in Japanese Pediatric Subjects Completed NCT01000207 Phase 2, Phase 3
27 Safety and Immunogenicity of A/H1N1-SOIV (Swine Flu) Vaccine With and Without Adjuvant in Children (3 to < 9 Years) Completed NCT00972816 Phase 2, Phase 3
28 Study of Swine-Origin A/H1N1 Influenza Non-Adjuvanted Vaccine in Healthy Adults in India Completed NCT01053143 Phase 3
29 Safety and Immunogenicity of A/H1N1-SOIV (Swine Flu) Vaccine With and Without Adjuvant in Children, Adolescents and Adults (3 to 64 Years) Completed NCT00973700 Phase 3
30 Safety and Immunogenicity of A/H1N1-SOIV (Swine Flu) Vaccine With and Without Adjuvant in Non-Elderly and Elderly Adults Completed NCT00973349 Phase 2, Phase 3
31 Single-blind, Dose-ranging Study of Novel Swine Influenza Virus Vaccine in Japanese Adult Subjects Completed NCT00996138 Phase 2, Phase 3
32 Immunogenicity, Safety, and Tolerability of MF59-Adjuvanted Versus Non-Adjuvanted Influenza Vaccines in Patients With HIV-1 Infection Completed NCT01032408 Phase 3
33 Clinical Trial to Compare the Immunogenicity, Safety, and Tolerability of an Adjuvanted A(H1N1) Influenza Vaccine Versus Non-Adjuvanted A(H1N1) Influenza Vaccines in Patients With Invasive Solid Tumors Completed NCT01031719 Phase 3
34 Immunogenicity and Safety Study of an Investigational Influenza (H1N1 Influenza Virus) Vaccine in Adults Completed NCT00989287 Phase 2, Phase 3
35 Study to Evaluate the Immunogenicity and Safety of an Investigational Influenza (H1N1 Influenza Virus) Vaccine in Adults, Using Two Different Manufacturing Processes Completed NCT00992511 Phase 3
36 Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine in Healthy Subjects 18 or More Years of Age Completed NCT00971906 Phase 3
37 Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine (Egg-Derived) in Healthy Subjects From 6 Months to 17 Years of Age Completed NCT00971542 Phase 3
38 Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine in Healthy Subjects From 6 Months to 17 Years of Age Completed NCT00971100 Phase 3
39 Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine in Healthy Subjects 18 or More Years of Age Completed NCT00970177 Phase 3
40 Does Seasonal Influenza Vaccination Affect the Incidence of pH1N1 Influenza? Completed NCT01001325 Phase 3
41 Immunogenicity, Safety, and Tolerability of an MF59-Adjuvanted Versus Non-Adjuvanted Influenza Vaccines in Patients With Chronic Pulmonary Disease, Chronic Heart Disease, or Diabetes Mellitus Completed NCT01032395 Phase 3
42 Pivotal, Multicenter, Observer-Blind, Randomized Study of Influenza A (H1N1)2009 Monovalent Subunit Vaccine With and Without Adjuvant in Children Ages 6 to <36 Months Completed NCT00996307 Phase 2, Phase 3
43 Safety and Efficacy of H1N1 Vaccines in Children Aged 6 Months to Less Than 10 Years of Age Completed NCT01051661 Phase 3
44 A Study to Evaluate the Safety and Immunogenicity of an Inactivated Split-virion Influenza A(H1N1) Vaccine Completed NCT01201902 Phase 3
45 A Clinical Trial Comparing Oseltamivir With Placebo And Zanamivir With Control As First Line Treatment For Human Swine Influenza Infection Terminated NCT00979667 Phase 3 Oseltamivir;Zanamivir;Placebo of Oseltamivir
46 Low Doses Corticosteroids as Adjuvant Therapy for the Treatment of Severe H1N1 Flu Terminated NCT01014364 Phase 3 hydrocortisone;isotonic saline
47 Basic and Clinical Research on Applying Blood Fix to Treat Critical H1N1 Patients Unknown status NCT01055990 Phase 2
48 A Study of Swine-origin A/H1N1 Influenza Vaccines in Healthy Europeans Children Aged 6 to 35 Months Completed NCT00956046 Phase 2
49 A Study of the Immunogenicity of Swine-origin A/H1N1 Influenza Vaccine in Healthy Adults Completed NCT01089660 Phase 2
50 A Study of Inactivated Swine-Origin A/H1N1 Influenza Vaccines in Healthy European Subjects Aged 3 to 17 Years Completed NCT00956202 Phase 2

Search NIH Clinical Center for Swine Influenza

Genetic Tests for Swine Influenza

Anatomical Context for Swine Influenza

MalaCards organs/tissues related to Swine Influenza:

42
Testes, Heart, T Cells, Lymph Node, Neutrophil, Brain, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Swine Influenza:

20
Respiratory Tract Of Pigs

Publications for Swine Influenza

Articles related to Swine Influenza:

(show top 50) (show all 814)
# Title Authors Year
1
Prevalence, distribution and risk factors of farmer reported swine influenza infection in Guangdong Province, China. ( 31027710 )
2019
2
Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus. ( 30914224 )
2019
3
Cellular Innate Immunity against PRRSV and Swine Influenza Viruses. ( 30862035 )
2019
4
Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition. ( 30355680 )
2019
5
Retraction statement: 'Hidden authority study data have come to light: besides narcolepsy the swine influenza vaccine Pandemrix caused type 1 diabetes'. ( 30835368 )
2018
6
Complete Genome Sequence of H1N1 Swine Influenza Virus from Pigs in the Republic of Korea in 2016. ( 30574580 )
2018
7
Development of a novel oil-in-water emulsion and evaluation of its potential adjuvant function in a swine influenza vaccine in mice. ( 30577861 )
2018
8
Tulathromycin enhances humoral but not cellular immune response in pigs vaccinated against swine influenza. ( 30585339 )
2018
9
Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine. ( 30507946 )
2018
10
Eurasian avian-like swine influenza A viruses escape human MxA restriction by distinct mutations in their nucleoprotein. ( 30355693 )
2018
11
Protective efficacy of a high-growth reassortant H1N1 influenza virus vaccine against the European Avian-like H1N1 swine influenza virus in mice and pigs. ( 30080677 )
2018
12
Swine Influenza Virus Induces RIPK1/DRP1-Mediated Interleukin-1 Beta Production. ( 30096906 )
2018
13
Detailed mapping of the linear B Cell epitopes of the hemagglutinin (HA) protein of swine influenza virus. ( 30029012 )
2018
14
Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model. ( 30053826 )
2018
15
Swine influenza viruses in Northern Vietnam in 2013-2014. ( 29967457 )
2018
16
Subtyping of Swine Influenza Viruses Using a High-Throughput Real-Time PCR Platform. ( 29872645 )
2018
17
Effects of Isatis root polysaccharide in mice infected with H3N2 swine influenza virus. ( 29890386 )
2018
18
Emergence of Eurasian Avian-Like Swine Influenza A (H1N1) Virus from an Adult Case in Fujian Province, China. ( 29797225 )
2018
19
Genetic analysis of human and swine influenza A viruses isolated in Northern Italy during 2010-2015. ( 28791803 )
2018
20
Influence of microclimate conditions on the cumulative exposure of nursery pigs to swine influenza A viruses. ( 28940764 )
2018
21
Evidence of infection with avian, human, and swine influenza viruses in pigs in Cairo, Egypt. ( 29075888 )
2018
22
Isolation and molecular characterization of an H5N1 swine influenza virus in China in 2015. ( 29164401 )
2018
23
The PB2-K627E mutation attenuates H3N2 swine influenza virus in cultured cells and in mice. ( 29175013 )
2018
24
Corrigendum to "Molecular epidemiology of swine influenza A viruses in the Southeastern United States, highlights regional differences in circulating strains'' [Vet. Microbiol. 211 (2017) 174-179]. ( 29274732 )
2018
25
Molecular subtyping of European swine influenza viruses and scaling to high-throughput analysis. ( 29316958 )
2018
26
Intradermal immunization with inactivated swine influenza virus and adjuvant polydi(sodium carboxylatoethylphenoxy)phosphazene (PCEP) induced humoral and cell-mediated immunity and reduced lung viral titres in pigs. ( 29454517 )
2018
27
Molecular evolution of H1N1 swine influenza in Guangdong, China, 2016-2017. ( 29477550 )
2018
28
Maternally-derived antibodies do not inhibit swine influenza virus replication in piglets but decrease excreted virus infectivity and impair post-infectious immune responses. ( 29519509 )
2018
29
A Naturally Occurring Deletion in the Effector Domain of H5N1 Swine Influenza Virus Nonstructural Protein 1 Regulates Viral Fitness and Host Innate Immunity. ( 29563291 )
2018
30
Effects of the S42 residue of the H1N1 swine influenza virus NS1 protein on interferon responses and virus replication. ( 29587786 )
2018
31
Regional patterns of genetic diversity in swine influenza A viruses in the United States from 2010 to 2016. ( 29624873 )
2018
32
Monoclonal Antibody Against HA Protein of the European Avian-Like H1N1 Swine Influenza Virus. ( 29630477 )
2018
33
Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses. ( 29717109 )
2018
34
Pig Lung Immune Cytokine Response to the Swine Influenza Virus and the Actinobacillus Pleuropneumoniae Infection. ( 29978082 )
2017
35
Hidden authority study data have come to light: besides narcolepsy, the swine influenza vaccine Pandemrix caused type 1 diabetes. ( 27995691 )
2017
36
A cross-sectional study of swine influenza in intensive and extensive farms in the northeastern region of the state of São Paulo, Brazil. ( 27637594 )
2017
37
Effects of PB1-F2 on the pathogenicity of H1N1 swine influenza virus in mice and pigs. ( 28008819 )
2017
38
Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous cell-mediated immune response in pigs. ( 28057521 )
2017
39
Detection of Antigenic Variants of Subtype H3 Swine Influenza A Viruses from Clinical Samples. ( 28077698 )
2017
40
Swine Influenza Virus (H1N2) Characterization and Transmission in Ferrets, Chile. ( 28098524 )
2017
41
Pathogenicity of modified bat influenza virus with different M genes and its reassortment potential with swine influenza A virus. ( 28100299 )
2017
42
Polyanhydride nanovaccine against swine influenza virus in pigs. ( 28117173 )
2017
43
Swine influenza A (H1N1) virus (SIV) infection requiring extracorporeal life support in an immunocompetent adult patient with indirect exposure to pigs, Italy, October 2016. ( 28183395 )
2017
44
Estimation of the transmission parameters for swine influenza and porcine reproductive and respiratory syndrome viruses in pigs from weaning to slaughter under natural conditions. ( 28237230 )
2017
45
Kaempferol ameliorates H9N2 swine influenza virus-induced acute lung injury by inactivation of TLR4/MyD88-mediated NF-κB and MAPK signaling pathways. ( 28262619 )
2017
46
Protection of human influenza vaccines against a reassortant swine influenza virus of pandemic H1N1 origin using a pig model. ( 28267619 )
2017
47
Kinetics of single and dual infection of pigs with swine influenza virus and Actinobacillus pleuropneumoniae. ( 28284596 )
2017
48
Pathogenicity and transmission of triple reassortant H3N2 swine influenza A viruses is attenuated following Turkey embryo propagation. ( 28284612 )
2017
49
Authors' reply: Two severe human cases due to swine influenza A (H1N1)v in October 2016 in Europe were chronologic coincident yet distinct events. ( 28300530 )
2017
50
Letter to the editor: Just a coincidence? Two severe human cases due to swine influenza (SIV) A(H1N1)v in Europe, October 2016. ( 28300531 )
2017

Variations for Swine Influenza

Expression for Swine Influenza

Search GEO for disease gene expression data for Swine Influenza.

Pathways for Swine Influenza

GO Terms for Swine Influenza

Biological processes related to Swine Influenza according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of insulin secretion GO:0050796 8.62 SLC8B1 TNF

Sources for Swine Influenza

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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