MCID: SYM002
MIFTS: 47

Sympathetic Ophthalmia

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Sympathetic Ophthalmia

MalaCards integrated aliases for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 12 60 15 17
Ophthalmia, Sympathetic 45 74
Sympathetic Uveitis 12 60

Characteristics:

Orphanet epidemiological data:

60
sympathetic ophthalmia
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 60  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:12029
ICD9CM 36 360.11
MeSH 45 D009879
SNOMED-CT 69 75315001
ICD10 34 H44.13
MESH via Orphanet 46 D009879
ICD10 via Orphanet 35 H44.1
UMLS via Orphanet 75 C0029077
Orphanet 60 ORPHA79098
UMLS 74 C0029077

Summaries for Sympathetic Ophthalmia

Disease Ontology : 12 A panuveitis that is characterized by bilateral diffuse intraocular inflammation following penetrating trauma to an eye, has symptom blurry vision, watering, pain, and photophobia.

MalaCards based summary : Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to vogt-koyanagi-harada disease and autoimmune disease, and has symptoms including blurry vision An important gene associated with Sympathetic Ophthalmia is HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ Alpha 1), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Triamcinolone and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and bone, and related phenotypes are hematopoietic system and immune system

Wikipedia : 77 Sympathetic ophthalmia (SO) or sympathetic uveitis is a diffuse granulomatous inflammation of the uveal... more...

Related Diseases for Sympathetic Ophthalmia

Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 vogt-koyanagi-harada disease 30.7 HLA-DQA1 HLA-DRB1
2 autoimmune disease 29.3 CTLA4 HLA-DRB1 PDCD1 TNF
3 endophthalmitis 10.4
4 cataract 10.4
5 melanoma 10.4
6 retinal detachment 10.3
7 echinococcosis 10.3 HLA-DRB1 TNF
8 microscopic polyangiitis 10.3 HLA-DRB1 TNF
9 chronic beryllium disease 10.3 HLA-DRB1 TNF
10 endometritis 10.3 HLA-DQA1 TNF
11 hirata disease 10.3 HLA-DQA1 HLA-DRB1
12 microscopic colitis 10.3 HLA-DRB1 TNF
13 nontuberculous mycobacterial lung disease 10.3 HLA-DRB1 TNF
14 central nervous system vasculitis 10.3 HLA-DRB1 TNF
15 rheumatoid vasculitis 10.3 HLA-DRB1 TNF
16 streptococcal toxic-shock syndrome 10.3 LTA TNF
17 transient hypogammaglobulinemia 10.3 LTA TNF
18 eosinophilia-myalgia syndrome 10.3 HLA-DQA1 HLA-DRB1
19 null-cell leukemia 10.3 LTA TNF
20 idiopathic achalasia 10.3 LTA TNF
21 panuveitis 10.2 HLA-DRB1 TNF
22 histoplasmosis 10.2 HLA-DQA1 HLA-DRB1
23 listeria meningitis 10.2 LTA TNF
24 dengue shock syndrome 10.2 HLA-DRB1 TNF
25 acute disseminated encephalomyelitis 10.2 HLA-DQA1 HLA-DRB1
26 palindromic rheumatism 10.2 HLA-DRB1 TNF
27 spondylarthropathy 10.2 LTA TNF
28 post-transplant lymphoproliferative disease 10.2 LTA TNF
29 idiopathic neutropenia 10.2 HLA-DRB1 TNF
30 monoclonal gammopathy of uncertain significance 10.2 LTA TNF
31 focal epithelial hyperplasia 10.2 HLA-DQA1 HLA-DRB1
32 hemorrhagic fever with renal syndrome 10.2 HLA-DRB1 TNF
33 miliary tuberculosis 10.2 PDCD1 TNF
34 mixed connective tissue disease 10.2 HLA-DRB1 TNF
35 guillain-barre syndrome 10.2 HLA-DQA1 TNF
36 primary progressive multiple sclerosis 10.2 HLA-DRB1 TNF
37 acute respiratory distress syndrome 10.2 LTA TNF
38 temporal arteritis 10.2 HLA-DRB1 TNF
39 progressive multifocal leukoencephalopathy 10.2 ITGA4 TNF
40 pediatric multiple sclerosis 10.2 HLA-DRB1 ITGA4
41 dengue hemorrhagic fever 10.2 HLA-DRB1 TNF
42 trachoma 10.1 HLA-C TNF
43 typhoid fever 10.1 LTA TNF
44 mumps 10.1 HLA-DRB1 TNF
45 keratitis, hereditary 10.1
46 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
47 vacterl association 10.1
48 neovascular glaucoma 10.1
49 tonsillitis 10.1 LTA TNF
50 pityriasis rosea 10.1 HLA-C HLA-DRB1

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to Sympathetic Ophthalmia

Symptoms & Phenotypes for Sympathetic Ophthalmia

Symptoms:

12
  • blurry vision

MGI Mouse Phenotypes related to Sympathetic Ophthalmia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CTLA4 HLA-DQA1 ITGA4 LTA PDCD1 TNF
2 immune system MP:0005387 9.1 CTLA4 HLA-DQA1 ITGA4 LTA PDCD1 TNF

Drugs & Therapeutics for Sympathetic Ophthalmia

Drugs for Sympathetic Ophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 1, Phase 2,Not Applicable 124-94-7 31307
2
tannic acid Approved Phase 2 1401-55-4
3
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
4
Ustekinumab Approved, Investigational Phase 2 815610-63-0
5
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
6 Hormones Phase 1, Phase 2,Phase 2,Not Applicable
7 Triamcinolone hexacetonide Phase 1, Phase 2,Not Applicable
8 Immunologic Factors Phase 1, Phase 2,Not Applicable
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2,Phase 2,Not Applicable
10 triamcinolone acetonide Phase 1, Phase 2,Not Applicable
11 Immunosuppressive Agents Phase 1, Phase 2,Not Applicable
12 glucocorticoids Phase 1, Phase 2,Phase 2,Not Applicable
13 Triamcinolone diacetate Phase 1, Phase 2,Not Applicable
14 Anti-Inflammatory Agents Phase 1, Phase 2,Phase 2,Not Applicable
15 Hormone Antagonists Phase 1, Phase 2,Phase 2,Not Applicable
16 Dermatologic Agents Phase 2,Not Applicable
17 Antineoplastic Agents, Hormonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage Glaucoma Unknown status NCT00349414 Phase 1, Phase 2
2 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2 triamcinolone acetonide (Triesence®)
3 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
4 A Multicenter Phase 2 Single-arm Proof-of-concept Trial to Assess the Efficacy and Safety of Ustekinumab in Association With Prednisone for the Treatment of Non-infectious Severe Uveitis (NISU) Not yet recruiting NCT03847272 Phase 2 prednisone and ustekinumab treatment
5 Comparative Effectiveness and Tolerance of Subliminal Subthreshold Transscleral Cyclophotocoagulation Completed NCT03961035
6 Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMD Withdrawn NCT02457026 Not Applicable Aflibercept;Triamcinolone Acetonide;Verteporfin

Search NIH Clinical Center for Sympathetic Ophthalmia

Cochrane evidence based reviews: ophthalmia, sympathetic

Genetic Tests for Sympathetic Ophthalmia

Anatomical Context for Sympathetic Ophthalmia

MalaCards organs/tissues related to Sympathetic Ophthalmia:

42
Eye, Retina, Bone, Heart, Tongue, Tonsil

Publications for Sympathetic Ophthalmia

Articles related to Sympathetic Ophthalmia:

(show top 50) (show all 357)
# Title Authors Year
1
Sympathetic Ophthalmia after Vitreoretinal Surgeries: Incidence, Clinical Presentations and Outcomes of a Rare Disease. ( 31055985 )
2019
2
Comparison of Clinical Features and Visual Outcome between Sympathetic Ophthalmia and Vogt-Koyanagi-Harada Disease in Chinese Patients. ( 30959067 )
2019
3
A rare case of atypical sympathetic ophthalmia. ( 30879836 )
2019
4
Rare case of sympathetic ophthalmia with severe annular choroidal detachment. ( 30851801 )
2019
5
Sympathetic ophthalmia following cyclodialysis cleft repair. ( 30801884 )
2019
6
Effective treatment of refractory sympathetic ophthalmia with glaucoma using adalimumab. ( 30766937 )
2019
7
NOVEL OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF A CASE OF SYMPATHETIC OPHTHALMIA AFTER 23-GAUGE VITRECTOMY. ( 30668552 )
2019
8
Progressive, subretinal fibrosis mimicking retinal necrosis with poor visual prognosis in sympathetic ophthalmia: A rare finding. ( 30451212 )
2018
9
Treatment Response in Sympathetic Ophthalmia as Assessed by Widefield OCT Angiography. ( 30222810 )
2018
10
Analysis of 130 Cases of Sympathetic Ophthalmia - A Retrospective Multicenter Case Series. ( 30207811 )
2018
11
Intravitreal Aflibercept as an Adjunct to Systemic Therapy in a Case of Choroidal Neovascular Membrane Associated with Sympathetic Ophthalmia. ( 30202619 )
2018
12
Surgical Intervention in Inciting Eyes of Patients with Sympathetic Ophthalmia: A Case Series and Review of Literature. ( 30081702 )
2018
13
Dexamethasone Implant as Sole Therapy in Sympathetic Ophthalmia. ( 29928220 )
2018
14
Sympathetic ophthalmia presenting with signs of frosted branch angiitis: Report of a case. ( 29563696 )
2018
15
Postsurgical sympathetic ophthalmia: retrospective analysis of a rare entity. ( 29164454 )
2018
16
Sympathetic Ophthalmia Following Accidental Burn with Hot Water Involving the Other Eye. ( 28910553 )
2018
17
Sympathetic Ophthalmia: Experience from a Tertiary Care Center in Northern India. ( 30479714 )
2018
18
Sympathetic ophthalmia in fellow eye after vitrectomy for massive subretinal hemorrhage secondary to polypoidal choroidal vasculopathy. ( 30464649 )
2018
19
Sympathetic ophthalmia associated with untreated choroidal melanoma. ( 30340733 )
2018
20
Bilateral sensorineural hearing loss secondary to sympathetic ophthalmia in a human leukocyte antigen-A2 positive patient. ( 29118502 )
2017
21
Early Recovery of Sympathetic Ophthalmia with Hearing Loss in a Young Man. ( 29308342 )
2017
22
Association of a PDCD1 Polymorphism With Sympathetic Ophthalmia in Han Chinese. ( 28846771 )
2017
23
Sympathetic ophthalmia related to conjunctival invasive squamous-cell carcinoma. ( 28820163 )
2017
24
Sympathetic Ophthalmia. ( 28414613 )
2017
25
Multimodal Imaging in Sympathetic Ophthalmia. ( 27960610 )
2017
26
AN ATYPICAL CASE OF SYMPATHETIC OPHTHALMIA AFTER LIMBAL CORNEAL LACERATION. ( 27124790 )
2017
27
Long-Term Drug-Free Remission and Visual Outcomes in Sympathetic Ophthalmia. ( 26808121 )
2017
28
Lymphocytic Meningitis in Patients with Sympathetic Ophthalmia. ( 28281853 )
2017
29
Cyclophotocoagulation-induced sympathetic ophthalmia in a Coats' disease patient supported by histopathology and immunohistochemistry. ( 28820164 )
2017
30
Characteristics of Sympathetic Ophthalmia in a Single International Center. ( 27651849 )
2016
31
A rare case of atypical sympathetic ophthalmia post therapeutic keratoplasty. ( 27638462 )
2016
32
Sympathetic ophthalmia following a conjunctival flap procedure for corneal perforation. ( 26976837 )
2016
33
Sympathetic Ophthalmia after Ocular Wasp Sting. ( 26635462 )
2015
34
A case of sympathetic ophthalmia after 23-gauge transconjunctival sutureless vitrectomy. ( 26028951 )
2015
35
Sympathetic ophthalmia caused by a severe ocular chemical burn: a case report and literature review. ( 25932266 )
2015
36
Enhanced depth imaging OCT (EDI-OCT) findings in acute phase of sympathetic ophthalmia. ( 25772275 )
2015
37
Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. ( 25720920 )
2015
38
SYMPATHETIC OPHTHALMIA: Clinicopathologic Correlation in a Consecutive Case Series. ( 25719985 )
2015
39
Spontaneous dislocation of a fluocinolone acetonide implant (Retisert) into the anterior chamber and its successful extraction in sympathetic ophthalmia. ( 25411930 )
2015
40
Spectral-domain optical coherence tomography of sympathetic ophthalmia with Dalen-Fuchs nodules. ( 25347826 )
2014
41
Multiple serous retinal detachments seen on wide-field imaging in a patient with sympathetic ophthalmia. ( 25171189 )
2014
42
Sympathetic ophthalmia after diode laser cyclophotocoagulation: now an issue in informed consent. ( 25103662 )
2014
43
Classical pathology of sympathetic ophthalmia presented in a unique case. ( 25067979 )
2014
44
Adalimumab for pediatric sympathetic ophthalmia. ( 25010359 )
2014
45
Gender differences in vogt-koyanagi-harada disease and sympathetic ophthalmia. ( 24734166 )
2014
46
Sympathetic ophthalmia following diode laser cyclophotocoagulation. ( 24711656 )
2014
47
Long-term, drug-free remission of sympathetic ophthalmia with high-dose, short-term chlorambucil therapy. ( 24572676 )
2014
48
Sympathetic ophthalmia in pediatric age group: clinical features and challenges in management in a tertiary center in southern India. ( 24131076 )
2014
49
Reversible alopecia in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. ( 23514340 )
2013
50
Presumed sympathetic ophthalmia after scleral buckling surgery. ( 25383825 )
2013

Variations for Sympathetic Ophthalmia

Expression for Sympathetic Ophthalmia

Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for Sympathetic Ophthalmia

Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4 LTA
2
Show member pathways
13.11 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4 PDCD1
3
Show member pathways
13.04 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
4
Show member pathways
12.71 HLA-C HLA-DQA1 HLA-DRB1 ITGA4
5
Show member pathways
12.35 HLA-DQA1 HLA-DRB1 TNF
6 12.31 CTLA4 PDCD1 TNF
7
Show member pathways
12.31 CTLA4 PDCD1 TNF
8
Show member pathways
12.27 HLA-C HLA-DQA1 HLA-DRB1
9
Show member pathways
12.24 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4 LTA
10
Show member pathways
12.15 CTLA4 HLA-DQA1 HLA-DRB1
11
Show member pathways
12.01 HLA-C LTA TNF
12 11.98 HLA-DQA1 HLA-DRB1 TNF
13
Show member pathways
11.98 HLA-DQA1 HLA-DRB1 ITGA4 TNF
14
Show member pathways
11.91 CTLA4 HLA-DQA1 HLA-DRB1 PDCD1
15 11.89 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
16 11.88 HLA-C HLA-DQA1 HLA-DRB1
17
Show member pathways
11.72 HLA-DQA1 HLA-DRB1 PDCD1
18 11.61 HLA-DQA1 HLA-DRB1 ITGA4 TNF
19 11.57 ITGA4 LTA TNF
20 11.52 CTLA4 HLA-DQA1 HLA-DRB1 TNF
21 11.5 CTLA4 HLA-DQA1 HLA-DRB1
22 11.47 HLA-DQA1 HLA-DRB1
23 11.41 CTLA4 PDCD1
24 11.36 LTA TNF
25 11.34 CTLA4 HLA-DQA1 HLA-DRB1
26
Show member pathways
11.31 LTA TNF
27 11.26 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4 PDCD1
28 11.08 CTLA4 PDCD1
29 11.03 HLA-DRB1 TNF

GO Terms for Sympathetic Ophthalmia

Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.76 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4 LTA
2 cell surface GO:0009986 9.67 HLA-C HLA-DRB1 ITGA4 TNF
3 external side of plasma membrane GO:0009897 9.56 CTLA4 HLA-DRB1 PDCD1 TNF
4 transport vesicle membrane GO:0030658 9.46 HLA-DQA1 HLA-DRB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.4 HLA-DQA1 HLA-DRB1
6 MHC class II protein complex GO:0042613 9.32 HLA-DQA1 HLA-DRB1
7 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-C HLA-DQA1 HLA-DRB1
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-C HLA-DQA1 HLA-DRB1
9 membrane GO:0016020 10.03 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4 LTA
10 integral component of membrane GO:0016021 10.02 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4 PDCD1

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.81 CTLA4 HLA-C HLA-DQA1 HLA-DRB1
2 positive regulation of apoptotic process GO:0043065 9.71 CTLA4 LTA PDCD1 TNF
3 T cell costimulation GO:0031295 9.55 CTLA4 PDCD1
4 positive regulation of interferon-gamma production GO:0032729 9.54 LTA TNF
5 interferon-gamma-mediated signaling pathway GO:0060333 9.54 HLA-C HLA-DQA1 HLA-DRB1
6 negative regulation of T cell proliferation GO:0042130 9.52 CTLA4 HLA-DRB1
7 leukocyte tethering or rolling GO:0050901 9.49 ITGA4 TNF
8 positive regulation of glial cell proliferation GO:0060252 9.48 LTA TNF
9 negative regulation of growth of symbiont in host GO:0044130 9.46 LTA TNF
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.43 HLA-DQA1 HLA-DRB1
11 humoral immune response GO:0006959 9.43 LTA PDCD1 TNF
12 antigen processing and presentation GO:0019882 9.33 HLA-C HLA-DQA1 HLA-DRB1
13 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.32 LTA TNF
14 immune response GO:0006955 9.1 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
15 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF

Molecular functions related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.16 LTA TNF
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQA1 HLA-DRB1
3 peptide antigen binding GO:0042605 8.8 HLA-C HLA-DQA1 HLA-DRB1

Sources for Sympathetic Ophthalmia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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