MCID: SYM002
MIFTS: 45

Sympathetic Ophthalmia

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Sympathetic Ophthalmia

MalaCards integrated aliases for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 12 58 15 17
Ophthalmia, Sympathetic 44 70
Sympathetic Uveitis 12 58

Characteristics:

Orphanet epidemiological data:

58
sympathetic ophthalmia
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:12029
ICD9CM 34 360.11
MeSH 44 D009879
SNOMED-CT 67 75315001
ICD10 32 H44.13
MESH via Orphanet 45 D009879
ICD10 via Orphanet 33 H44.1
UMLS via Orphanet 71 C0029077
Orphanet 58 ORPHA79098
UMLS 70 C0029077

Summaries for Sympathetic Ophthalmia

Disease Ontology : 12 A panuveitis that is characterized by bilateral diffuse intraocular inflammation following penetrating trauma to an eye, has symptom blurry vision, watering, pain, and photophobia.

MalaCards based summary : Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to panuveitis and iridocyclitis, and has symptoms including blurry vision An important gene associated with Sympathetic Ophthalmia is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include eye, skin and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 73 Sympathetic ophthalmia (SO), also called spared eye injury, is a diffuse granulomatous inflammation of... more...

Related Diseases for Sympathetic Ophthalmia

Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 382)
# Related Disease Score Top Affiliating Genes
1 panuveitis 31.0 TNF RBP3 IL10 HLA-DRB1
2 iridocyclitis 31.0 TNF RBP3 IL10
3 vogt-koyanagi-harada disease 30.9 IL10 HLA-DRB1 HLA-DQA1 HLA-C
4 choroiditis 30.8 TNF RBP3 IL10
5 endophthalmitis 30.8 TNF SELE ICAM1
6 retinal detachment 30.8 TNF IL10 CXCL12
7 posterior uveitis 30.7 TNF RBP3 LTA
8 multifocal choroiditis 30.5 TNF IL10
9 chorioretinitis 30.5 TNF RBP3 IL10
10 syphilis 30.5 TNF HLA-DRB1 HLA-C
11 hypopyon 30.3 TNF RBP3 IL10
12 uveitis 30.3 TNFRSF1A TNF RBP3 LTA IL10 ICAM1
13 iritis 30.3 TNF RBP3 IL10
14 intermediate uveitis 30.3 TNF IL10 HLA-DRB1
15 vitiligo-associated multiple autoimmune disease susceptibility 1 30.3 TNF PDCD1 CTLA4
16 chickenpox 30.3 TNF IL10 CTLA4
17 macular retinal edema 30.2 TNF ICAM1 CXCL12
18 sarcoidosis 1 30.2 TNF LTA ICAM1 HLA-DRB1
19 scleritis 30.2 TNF SELE CTLA4
20 meningitis 30.0 TNF IL10 ICAM1
21 conjunctivitis 29.9 TNF IL10 ICAM1
22 autoimmune uveitis 29.6 TNF RBP3 IL10 ICAM1
23 microvascular complications of diabetes 5 29.5 VCAM1 ICAM1 CXCL12
24 vasculitis 29.5 VCAM1 TNF SELE ICAM1 CTLA4
25 proteasome-associated autoinflammatory syndrome 1 29.3 VCAM1 TNF SELE IL10 ICAM1
26 melanoma 29.0 TNF PDCD1 IL10 ICAM1 HLA-DRB1 CTLA4
27 autoimmune disease 28.8 VCAM1 TNFRSF1A TNF RBP3 PDCD1 LTA
28 eye disease 28.6 VCAM1 TNF RBP3 IL10 ICAM1 HLA-C
29 behcet syndrome 27.5 VCAM1 TNFRSF1A TNF SELE RBP3 LTA
30 intraocular pressure quantitative trait locus 10.5
31 cataract 10.5
32 pars planitis 10.4
33 punctate inner choroidopathy 10.4 TNF IL10
34 tropical endomyocardial fibrosis 10.4 TNF IL10
35 yemenite deaf-blind hypopigmentation syndrome 10.4
36 palladium allergic contact dermatitis 10.4 TNF IL10
37 streptococcal toxic-shock syndrome 10.4 TNF LTA
38 juvenile myasthenia gravis 10.4 IL10 HLA-DRB1
39 ifap syndrome 2 10.4
40 beryllium disease 10.4 TNF HLA-DRB1
41 null-cell leukemia 10.4 TNF LTA
42 primary adrenal insufficiency 10.3 HLA-DRB1 HLA-DQA1
43 adult-onset myasthenia gravis 10.3 HLA-DQA1 CTLA4
44 chronic beryllium disease 10.3 TNF HLA-DRB1
45 tertiary syphilis 10.3 TNF IL10
46 orbital plasma cell granuloma 10.3 LTA CTLA4
47 systemic onset juvenile idiopathic arthritis 10.3 TNF HLA-DRB1
48 metal allergy 10.3 IL10 HLA-DRB1
49 latent autoimmune diabetes in adults 10.3 HLA-DRB1 CTLA4
50 nontuberculous mycobacterial lung disease 10.3 TNF HLA-DRB1

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to Sympathetic Ophthalmia

Symptoms & Phenotypes for Sympathetic Ophthalmia

Symptoms:

12
  • blurry vision

GenomeRNAi Phenotypes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 IL10 LTA PDCD1 TNF TNFRSF1A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 ICAM1 IL10 LTA PDCD1 TNF TNFRSF1A
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.4 ICAM1

MGI Mouse Phenotypes related to Sympathetic Ophthalmia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.22 CD44 CTLA4 CXCL12 ICAM1 IL10 LTA
2 hematopoietic system MP:0005397 10.21 CD44 CTLA4 CXCL12 HLA-DQA1 ICAM1 IL10
3 immune system MP:0005387 10.18 CD44 CTLA4 CXCL12 HLA-DQA1 ICAM1 IL10
4 endocrine/exocrine gland MP:0005379 10.11 CD44 CTLA4 HLA-DQA1 ICAM1 IL10 LTA
5 mortality/aging MP:0010768 10.06 CD44 CTLA4 CXCL12 ICAM1 IL10 LTA
6 liver/biliary system MP:0005370 10.02 CD44 CTLA4 CXCL12 IL10 LTA PDCD1
7 muscle MP:0005369 9.8 CD44 CXCL12 ICAM1 IL10 PDCD1 TNF
8 neoplasm MP:0002006 9.63 CD44 ICAM1 IL10 PDCD1 TNF TNFRSF1A
9 respiratory system MP:0005388 9.56 CD44 CTLA4 IL10 LTA PDCD1 SELE
10 vision/eye MP:0005391 9.28 CD44 ICAM1 IL10 LTA PDCD1 RBP3

Drugs & Therapeutics for Sympathetic Ophthalmia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open-Label, Safety and Tolerability Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle in Subjects With Non-Infectious Uveitis Completed NCT01789320 Phase 1, Phase 2 triamcinolone acetonide (Triesence®)
2 Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in Patients With Neovascular Age-Related Macular Degeneration Withdrawn NCT02457026 Aflibercept;Triamcinolone Acetonide;Verteporfin

Search NIH Clinical Center for Sympathetic Ophthalmia

Cochrane evidence based reviews: ophthalmia, sympathetic

Genetic Tests for Sympathetic Ophthalmia

Anatomical Context for Sympathetic Ophthalmia

MalaCards organs/tissues related to Sympathetic Ophthalmia:

40
Eye, Skin, Bone, Lung, Heart, Kidney, Retina

Publications for Sympathetic Ophthalmia

Articles related to Sympathetic Ophthalmia:

(show top 50) (show all 798)
# Title Authors PMID Year
1
Atypical Sympathetic Ophthalmia Presenting with Ocular Pain Associated with Posterior Scleral Involvement. 61
33734929 2021
2
An Atypical Presentation of Sympathetic Ophthalmia in an Intact Globe Following Mechanical Fall: A Case Report and Literature Review. 61
33669961 2021
3
Persumed sympathetic Ophthalmia after scleral buckling surgery: case report. 61
33615391 2021
4
Efficacy and Safety of Adalimumab Therapy for the Treatment of Non-infectious Uveitis: Efficacy comparison among Uveitis Aetiologies. 61
33560160 2021
5
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis. 61
32422390 2021
6
Tracing Ocular Conditions in 15,921 Interwar Refugees, Veria, Greece (1926-1940). 61
33781073 2020
7
Sympathetic ophthalmia: Report of a case series and comprehensive review of the literature. 61
33256432 2020
8
Exudative Retinal Detachment in Ocular Inflammatory Diseases: Risk and Predictive Factors. 61
32621891 2020
9
Sympathetic Ophthalmia - a Contribution to Immunology, Clinic and Current Imaging. 61
32967030 2020
10
Early presentation of sympathetic ophthalmia in optical coherence tomography studies: A case report. 61
32823465 2020
11
Commentary: Optical coherence tomography in sympathetic ophthalmia. 61
32823466 2020
12
Sympathetic ophthalmia presenting 5 days after penetrating injury. 61
32695926 2020
13
miR-182-5p inhibits the pathogenic Th17 response in experimental autoimmune uveitis mice via suppressing TAF15. 61
32736708 2020
14
Recurrent Sympathetic Ophthalmia with Annular Choroidal Detachment after Pembrolizumab Treatment: A Case Report. 61
31260339 2020
15
Tuberculous choroiditis masquerading as sympathetic ophthalmia: a case report. 61
32844076 2020
16
Unusual presentation of Retinoblastoma. 61
32613860 2020
17
Sympathetic Ophthalmia Two Weeks After 23-Gauge Vitrectomy. 61
32588152 2020
18
Yellow Sub-Retinal Pigment Epithelium (YSRPE) Deposits: A Novel Sign in Ocular Tuberculosis. 61
32541431 2020
19
Pediatric Sympathetic Ophthalmia: 20 Years of Data From a Tertiary Eye Center in India. 61
32453848 2020
20
The Effectiveness and Safety of Micropulse Cyclophotocoagulation in the Treatment of Ocular Hypertension and Glaucoma. 61
32672613 2020
21
Retinal vascular inflammatory and occlusive changes in infectious and non-infectious uveitis. 61
32016664 2020
22
Evisceration Versus Enucleation Following Ocular Trauma, a Retrospective Analysis at a Level One Trauma Center. 61
31642476 2020
23
Lord Nelson's (1758-1805) left eye. 61
28972425 2020
24
Optical coherence tomography as a tool to detect early sympathetic ophthalmia in an asymptomatic patient. 61
31712032 2020
25
A rare entity: Sympathetic ophthalmia presumably after blunt trauma to the phthisical eye and optical coherence tomography angiography metrics to monitor response to treatment. 61
31998506 2020
26
Continuous ab interno repairing of traumatic cyclodialysis cleft using a 30-gauge needle in severe ocular trauma: a clinical observation. 61
31878971 2019
27
Sustained Control from Recurring Non-Infectious Uveitic Macular Edema with 0.19 mg Fluocinolone Acetonide Intravitreal Implant - A Case Report. 61
31506865 2019
28
Outcomes of ocular evisceration and enucleation in the British Armed Forces from Iraq and Afghanistan. 61
31165770 2019
29
Choroidal Structural Changes in Sympathetic Ophthalmia on Swept-Source Optical Coherence Tomography. 61
31743045 2019
30
Sympathetic ophthalmia with incidental finding of chicken pox supported by histopathology and immunohistochemistry. 61
31611447 2019
31
Comparison of Clinical Features and Visual Outcome between Sympathetic Ophthalmia and Vogt-Koyanagi-Harada Disease in Chinese Patients. 61
30959067 2019
32
Sympathetic ophthalmia following cyclodialysis cleft repair. 61
30801884 2019
33
Effective treatment of refractory sympathetic ophthalmia with glaucoma using adalimumab. 61
30766937 2019
34
Visual and ocular morbidity in severe open-globe injuries presenting to a regional eye centre in New Zealand. 61
30414237 2019
35
Cyclophotocoagulation with an illuminated laser probe under a noncontact wide-angle retinoscope: A modified technique of ciliary body photocoagulation. 61
30900585 2019
36
A rare case of atypical sympathetic ophthalmia. 61
30879836 2019
37
[Steroid implant in treatment of sympathetic ophthalmia : Intravitreal implant of dexamethasone in cystoid macular edema in the context of sympathetic ophthalmia]. 61
29948149 2019
38
Rare case of sympathetic ophthalmia with severe annular choroidal detachment. 61
30851801 2019
39
Surgical Intervention in Inciting Eyes of Patients with Sympathetic Ophthalmia: A Case Series and Review of Literature. 61
30081702 2019
40
Analysis of 130 Cases of Sympathetic Ophthalmia - A Retrospective Multicenter Case Series. 61
30207811 2019
41
[Atypical presentation of sympathetic ophthalmia]. 61
30598233 2019
42
Sympathetic Ophthalmia after Vitreoretinal Surgeries: Incidence, Clinical Presentations and Outcomes of a Rare Disease. 61
31055985 2019
43
NOVEL OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF A CASE OF SYMPATHETIC OPHTHALMIA AFTER 23-GAUGE VITRECTOMY. 61
30668552 2019
44
Exploring the role of programmed cell death protein 1 and its ligand 1 in eye diseases. 61
30602320 2019
45
The long-term monitoring of sympathetic ophthalmia in the diagnostic and terapeutic view. Review Department of Ophthalmology. 61
32397725 2019
46
Certification of Vision Impairment in Patients with Uveitis Attending a Specialist Clinic. 61
29543542 2019
47
Progressive, subretinal fibrosis mimicking retinal necrosis with poor visual prognosis in sympathetic ophthalmia: A rare finding. 61
30451212 2018
48
Postsurgical sympathetic ophthalmia: retrospective analysis of a rare entity. 61
29164454 2018
49
Sympathetic ophthalmia associated with untreated choroidal melanoma. 61
30340733 2018
50
Sympathetic Ophthalmia: Experience from a Tertiary Care Center in Northern India. 61
30479714 2018

Variations for Sympathetic Ophthalmia

Expression for Sympathetic Ophthalmia

Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for Sympathetic Ophthalmia

Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 VCAM1 TNFRSF1A TNF PDCD1 LTA IL10
2
Show member pathways
13.4 VCAM1 PDCD1 ICAM1 HLA-DRB1 HLA-DQA1 HLA-C
3
Show member pathways
13.3 VCAM1 TNFRSF1A TNF LTA IL10 ICAM1
4
Show member pathways
13.15 VCAM1 TNFRSF1A TNF SELE IL10 ICAM1
5
Show member pathways
12.89 TNFRSF1A TNF ICAM1 HLA-C CXCL12
6 12.79 TNFRSF1A TNF LTA HLA-DRB1 HLA-DQA1 HLA-C
7
Show member pathways
12.78 TNFRSF1A TNF ICAM1 HLA-DRB1 HLA-DQA1 HLA-C
8
Show member pathways
12.63 VCAM1 TNFRSF1A TNF IL10 ICAM1
9
Show member pathways
12.61 TNFRSF1A TNF IL10 HLA-DRB1 HLA-DQA1
10
Show member pathways
12.55 TNF PDCD1 IL10 CTLA4
11
Show member pathways
12.55 TNF LTA IL10 ICAM1 HLA-DRB1 HLA-DQA1
12
Show member pathways
12.54 TNF IL10 HLA-DRB1 HLA-DQA1
13
Show member pathways
12.52 VCAM1 ICAM1 HLA-DRB1 HLA-DQA1 HLA-C CD44
14
Show member pathways
12.37 VCAM1 SELE ICAM1 CD44
15 12.37 VCAM1 TNFRSF1A TNF PDCD1 IL10 CXCL12
16
Show member pathways
12.33 TNFRSF1A TNF LTA IL10 CXCL12
17 12.29 TNFRSF1A TNF LTA ICAM1 HLA-DRB1 HLA-DQA1
18
Show member pathways
12.26 TNFRSF1A TNF IL10 HLA-DRB1 HLA-DQA1
19
Show member pathways
12.25 TNF LTA IL10 HLA-C CXCL12
20 12.23 TNFRSF1A TNF IL10 HLA-DRB1 HLA-DQA1
21
Show member pathways
12.2 PDCD1 HLA-DRB1 HLA-DQA1 CTLA4
22 12.08 VCAM1 TNFRSF1A TNF SELE ICAM1
23 11.99 VCAM1 TNF IL10 ICAM1
24 11.98 VCAM1 TNFRSF1A TNF SELE LTA ICAM1
25 11.97 VCAM1 ICAM1 CD44
26 11.95 TNF IL10 CD44
27 11.93 VCAM1 TNF SELE ICAM1
28 11.93 VCAM1 TNFRSF1A TNF LTA ICAM1 CXCL12
29 11.92 TNF HLA-DRB1 HLA-DQA1 CD44
30
Show member pathways
11.91 PDCD1 HLA-DRB1 HLA-DQA1
31 11.9 IL10 ICAM1 HLA-DRB1 HLA-DQA1
32 11.81 TNF LTA IL10 CD44
33
Show member pathways
11.79 VCAM1 LTA CXCL12
34
Show member pathways
11.78 TNFRSF1A TNF LTA
35 11.77 TNF ICAM1 HLA-DRB1 HLA-DQA1 CXCL12 CTLA4
36
Show member pathways
11.74 TNF LTA IL10
37 11.73 VCAM1 SELE PDCD1 ICAM1 HLA-DRB1 HLA-DQA1
38
Show member pathways
11.71 VCAM1 TNFRSF1A TNF SELE ICAM1
39 11.7 HLA-DRB1 HLA-DQA1 CTLA4
40 11.58 TNFRSF1A TNF LTA
41 11.57 VCAM1 TNF SELE IL10 ICAM1
42
Show member pathways
11.55 TNFRSF1A TNF LTA
43 11.55 TNFRSF1A TNF IL10 ICAM1
44 11.48 VCAM1 SELE ICAM1
45
Show member pathways
11.38 TNFRSF1A TNF IL10
46 11.33 VCAM1 TNF SELE IL10 ICAM1
47 11.28 TNF IL10 HLA-DRB1
48 10.99 VCAM1 TNF PDCD1 LTA IL10 ICAM1
49 10.97 VCAM1 TNF ICAM1
50 10.64 TNF CXCL12

GO Terms for Sympathetic Ophthalmia

Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.22 VCAM1 TNFRSF1A TNF SELE PDCD1 ICAM1
2 plasma membrane GO:0005886 10.13 VCAM1 TNFRSF1A TNF SELE PDCD1 LTA
3 Golgi apparatus GO:0005794 9.95 VCAM1 TNFRSF1A HLA-DRB1 HLA-DQA1 HLA-C CTLA4
4 extracellular space GO:0005615 9.85 VCAM1 TNFRSF1A TNF SELE RBP3 LTA
5 cell surface GO:0009986 9.8 VCAM1 TNFRSF1A TNF ICAM1 HLA-DRB1 HLA-C
6 membrane raft GO:0045121 9.76 TNFRSF1A TNF SELE ICAM1
7 ER to Golgi transport vesicle membrane GO:0012507 9.61 HLA-DRB1 HLA-DQA1 HLA-C
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.54 HLA-DRB1 HLA-DQA1 HLA-C
9 external side of plasma membrane GO:0009897 9.5 VCAM1 TNF PDCD1 ICAM1 HLA-DRB1 CXCL12
10 MHC class II protein complex GO:0042613 9.49 HLA-DRB1 HLA-DQA1
11 integral component of plasma membrane GO:0005887 9.32 VCAM1 TNFRSF1A TNF SELE ICAM1 HLA-DRB1

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.03 VCAM1 SELE ICAM1 CXCL12 CD44
2 adaptive immune response GO:0002250 9.96 PDCD1 HLA-DRB1 HLA-DQA1 HLA-C CTLA4
3 extracellular matrix organization GO:0030198 9.91 VCAM1 TNF ICAM1 CD44
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 TNF ICAM1 HLA-DRB1 CD44
5 regulation of immune response GO:0050776 9.88 VCAM1 PDCD1 ICAM1 HLA-C
6 leukocyte migration GO:0050900 9.84 TNF SELE ICAM1 CD44
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.82 TNFRSF1A TNF LTA
8 response to hypoxia GO:0001666 9.8 VCAM1 LTA ICAM1 CXCL12
9 cytokine-mediated signaling pathway GO:0019221 9.77 VCAM1 TNFRSF1A TNF IL10 ICAM1
10 humoral immune response GO:0006959 9.72 TNF PDCD1 LTA
11 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.69 VCAM1 SELE ICAM1
12 positive regulation of glial cell proliferation GO:0060252 9.65 TNF LTA
13 negative regulation of B cell proliferation GO:0030889 9.65 IL10 CTLA4
14 antigen processing and presentation GO:0019882 9.65 HLA-DRB1 HLA-DQA1 HLA-C
15 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.64 TNF ICAM1
16 negative regulation of immune response GO:0050777 9.64 PDCD1 CTLA4
17 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.63 HLA-DRB1 HLA-DQA1
18 negative regulation of T cell proliferation GO:0042130 9.63 IL10 HLA-DRB1 CTLA4
19 positive regulation of ceramide biosynthetic process GO:2000304 9.62 TNFRSF1A TNF
20 regulation of establishment of endothelial barrier GO:1903140 9.62 TNFRSF1A TNF
21 endothelial cell apoptotic process GO:0072577 9.61 TNF IL10
22 leukocyte cell-cell adhesion GO:0007159 9.61 VCAM1 SELE ICAM1
23 death-inducing signaling complex assembly GO:0071550 9.6 TNFRSF1A TNF
24 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.58 TNF LTA
25 negative regulation of cytokine production involved in immune response GO:0002719 9.57 TNF IL10
26 immune response GO:0006955 9.56 TNF LTA IL10 HLA-DRB1 HLA-DQA1 HLA-C
27 response to lipopolysaccharide GO:0032496 9.55 VCAM1 SELE LTA IL10 ICAM1
28 membrane to membrane docking GO:0022614 9.52 VCAM1 ICAM1
29 leukocyte tethering or rolling GO:0050901 9.5 VCAM1 TNF SELE
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.43 TNF IL10 CD44
31 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.4 TNF LTA
32 interferon-gamma-mediated signaling pathway GO:0060333 9.1 VCAM1 ICAM1 HLA-DRB1 HLA-DQA1 HLA-C CD44

Molecular functions related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF LTA IL10 CXCL12
2 MHC class II receptor activity GO:0032395 9.16 HLA-DRB1 HLA-DQA1
3 peptide antigen binding GO:0042605 8.8 HLA-DRB1 HLA-DQA1 HLA-C

Sources for Sympathetic Ophthalmia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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