MCID: SYM002
MIFTS: 42

Sympathetic Ophthalmia

Categories: Eye diseases, Rare diseases, Immune diseases

Aliases & Classifications for Sympathetic Ophthalmia

MalaCards integrated aliases for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 12 59 15
Ophthalmia, Sympathetic 44 73
Sympathetic Uveitis 12 59

Characteristics:

Orphanet epidemiological data:

59
sympathetic ophthalmia
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:12029
ICD10 33 H44.13
ICD9CM 35 360.11
MeSH 44 D009879
SNOMED-CT 68 75315001
Orphanet 59 ORPHA79098
MESH via Orphanet 45 D009879
UMLS via Orphanet 74 C0029077
ICD10 via Orphanet 34 H44.1
UMLS 73 C0029077

Summaries for Sympathetic Ophthalmia

MalaCards based summary : Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to vogt-koyanagi-harada disease and autoimmune disease. An important gene associated with Sympathetic Ophthalmia is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Triamcinolone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include eye and retina.

Wikipedia : 76 Sympathetic ophthalmia (SO) or Sympathetic uveitis is a bilateral diffuse granulomatous uveitis (a kind... more...

Related Diseases for Sympathetic Ophthalmia

Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 vogt-koyanagi-harada disease 29.7 HLA-DQA1 HLA-DRB1
2 autoimmune disease 27.2 CTLA4 HLA-DQA1 HLA-DRB1 PDCD1 TNF
3 spondylarthropathy 10.6 LTA TNF
4 transient hypogammaglobulinemia 10.6 LTA TNF
5 streptococcal toxic-shock syndrome 10.6 LTA TNF
6 null-cell leukemia 10.6 LTA TNF
7 idiopathic achalasia 10.6 LTA TNF
8 microscopic polyangiitis 10.5 HLA-DRB1 TNF
9 listeria meningitis 10.5 LTA TNF
10 beryllium disease 10.5 HLA-DRB1 TNF
11 chronic beryllium disease 10.5 HLA-DRB1 TNF
12 monoclonal gammopathy of uncertain significance 10.5 LTA TNF
13 lichen sclerosus 10.5 HLA-DRB1 TNF
14 post-transplant lymphoproliferative disease 10.5 LTA TNF
15 actinic prurigo 10.5 HLA-DRB1 TNF
16 nontuberculous mycobacterial lung disease 10.5 HLA-DRB1 TNF
17 microscopic colitis 10.5 HLA-DRB1 TNF
18 central nervous system vasculitis 10.5 HLA-DRB1 TNF
19 rheumatoid vasculitis 10.5 HLA-DRB1 TNF
20 hemorrhagic fever 10.4 HLA-DRB1 TNF
21 acute respiratory distress syndrome 10.4 LTA TNF
22 panuveitis 10.4 HLA-DRB1 TNF
23 palindromic rheumatism 10.4 HLA-DRB1 TNF
24 hemorrhagic fever with renal syndrome 10.4 HLA-DRB1 TNF
25 rheumatic fever 10.4 HLA-DRB1 TNF
26 idiopathic neutropenia 10.4 HLA-DRB1 TNF
27 trachoma 10.4 HLA-C TNF
28 choroiditis 10.4
29 retinitis 10.4
30 mixed connective tissue disease 10.4 HLA-DRB1 TNF
31 echinococcosis 10.3 HLA-DRB1 TNF
32 tonsillitis 10.3 LTA TNF
33 dengue hemorrhagic fever 10.3 HLA-DRB1 TNF
34 pityriasis rosea 10.3 HLA-C HLA-DRB1
35 endophthalmitis 10.3
36 mumps 10.3 HLA-DRB1 TNF
37 retinal detachment 10.3
38 cataract 10.3
39 type 1 diabetes mellitus 12 10.2 CTLA4 HLA-DRB1
40 autoimmune addison disease 10.2 CTLA4 HLA-DRB1
41 melanoma 10.2
42 duodenal ulcer 10.2 LTA TNF
43 spondyloarthropathy 10.2 HLA-C TNF
44 paracoccidioidomycosis 10.2 CTLA4 TNF
45 rubella 10.2 HLA-DRB1 TNF
46 pemphigus foliaceus 10.2 CTLA4 HLA-DRB1
47 paraneoplastic pemphigus 10.1 HLA-C HLA-DRB1
48 myasthenic syndrome, congenital, 7, presynaptic 10.1 CTLA4 PDCD1
49 optic neuritis 10.1 HLA-DRB1 LTA TNF
50 sarcoidosis 1 10.1 HLA-DRB1 LTA TNF

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to Sympathetic Ophthalmia

Symptoms & Phenotypes for Sympathetic Ophthalmia

Drugs & Therapeutics for Sympathetic Ophthalmia

Drugs for Sympathetic Ophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 1, Phase 2,Not Applicable 124-94-7 31307
2
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
3 tannic acid Approved, Nutraceutical Phase 2
4 Anti-Inflammatory Agents Phase 1, Phase 2,Not Applicable
5 glucocorticoids Phase 1, Phase 2,Not Applicable
6 Hormone Antagonists Phase 1, Phase 2,Not Applicable
7 Hormones Phase 1, Phase 2,Not Applicable
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2,Not Applicable
9 Immunosuppressive Agents Phase 1, Phase 2,Not Applicable
10 triamcinolone acetonide Phase 1, Phase 2,Not Applicable
11 Triamcinolone diacetate Phase 1, Phase 2,Not Applicable
12 Triamcinolone hexacetonide Phase 1, Phase 2,Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage Glaucoma Unknown status NCT00349414 Phase 1, Phase 2
2 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2 triamcinolone acetonide (Triesence®)
3 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
4 Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMD Withdrawn NCT02457026 Not Applicable Aflibercept;Triamcinolone Acetonide;Verteporfin

Search NIH Clinical Center for Sympathetic Ophthalmia

Cochrane evidence based reviews: ophthalmia, sympathetic

Genetic Tests for Sympathetic Ophthalmia

Anatomical Context for Sympathetic Ophthalmia

MalaCards organs/tissues related to Sympathetic Ophthalmia:

41
Eye, Retina

Publications for Sympathetic Ophthalmia

Articles related to Sympathetic Ophthalmia:

(show top 50) (show all 331)
# Title Authors Year
1
Sympathetic ophthalmia presenting with signs of frosted branch angiitis: Report of a case. ( 29563696 )
2018
2
Dexamethasone Implant as Sole Therapy in Sympathetic Ophthalmia. ( 29928220 )
2018
3
Early Recovery of Sympathetic Ophthalmia with Hearing Loss in a Young Man. ( 29308342 )
2017
4
Association of a PDCD1 Polymorphism With Sympathetic Ophthalmia in Han Chinese. ( 28846771 )
2017
5
Postsurgical sympathetic ophthalmia: retrospective analysis of a rare entity. ( 29164454 )
2017
6
Lymphocytic Meningitis in Patients with Sympathetic Ophthalmia. ( 28281853 )
2017
7
Sympathetic ophthalmia related to conjunctival invasive squamous-cell carcinoma. ( 28820163 )
2017
8
Sympathetic Ophthalmia Following Accidental Burn with Hot Water Involving the Other Eye. ( 28910553 )
2017
9
Bilateral sensorineural hearing loss secondary to sympathetic ophthalmia in a human leukocyte antigen-A2 positive patient. ( 29118502 )
2017
10
Cyclophotocoagulation-induced sympathetic ophthalmia in a Coats' disease patient supported by histopathology and immunohistochemistry. ( 28820164 )
2017
11
Sympathetic Ophthalmia. ( 28414613 )
2017
12
AN ATYPICAL CASE OF SYMPATHETIC OPHTHALMIA AFTER LIMBAL CORNEAL LACERATION. ( 27124790 )
2016
13
Multimodal Imaging in Sympathetic Ophthalmia. ( 27960610 )
2016
14
Characteristics of Sympathetic Ophthalmia in a Single International Center. ( 27651849 )
2016
15
A rare case of atypical sympathetic ophthalmia post therapeutic keratoplasty. ( 27638462 )
2016
16
Long-Term Drug-Free Remission and Visual Outcomes in Sympathetic Ophthalmia. ( 26808121 )
2016
17
Sympathetic ophthalmia following a conjunctival flap procedure for corneal perforation. ( 26976837 )
2016
18
Sympathetic Ophthalmia after Ocular Wasp Sting. ( 26635462 )
2015
19
Spontaneous dislocation of a fluocinolone acetonide implant (retisert) into the anterior chamber and its successful extraction in sympathetic ophthalmia. ( 25411930 )
2015
20
A case of sympathetic ophthalmia after 23-gauge transconjunctival sutureless vitrectomy. ( 26028951 )
2015
21
Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. ( 25720920 )
2015
22
Sympathetic ophthalmia caused by a severe ocular chemical burn: a case report and literature review. ( 25932266 )
2015
23
SYMPATHETIC OPHTHALMIA: Clinicopathologic Correlation in a Consecutive Case Series. ( 25719985 )
2015
24
Enhanced depth imaging OCT (EDI-OCT) findings in acute phase of sympathetic ophthalmia. ( 25772275 )
2015
25
Spectral-Domain Optical Coherence Tomography of Sympathetic Ophthalmia With Dalen-Fuchs Nodules. ( 25347826 )
2014
26
Adalimumab for pediatric sympathetic ophthalmia. ( 25010359 )
2014
27
Sympathetic ophthalmia after diode laser cyclophotocoagulation: now an issue in informed consent. ( 25103662 )
2014
28
Multiple serous retinal detachments seen on wide-field imaging in a patient with sympathetic ophthalmia. ( 25171189 )
2014
29
Classical pathology of sympathetic ophthalmia presented in a unique case. ( 25067979 )
2014
30
Long-term, drug-free remission of sympathetic ophthalmia with high-dose, short-term chlorambucil therapy. ( 24572676 )
2014
31
Gender differences in vogt-koyanagi-harada disease and sympathetic ophthalmia. ( 24734166 )
2014
32
Sympathetic ophthalmia following diode laser cyclophotocoagulation. ( 24711656 )
2014
33
Presumed sympathetic ophthalmia after scleral buckling surgery. ( 25383825 )
2013
34
Sympathetic ophthalmia: to the twenty-first century and beyond. ( 23724856 )
2013
35
Sympathetic ophthalmia with sensorineural deafness - report of a case. ( 24225003 )
2013
36
Sympathetic Ophthalmia in Pediatric Age Group: Clinical Features and Challenges in Management in a Tertiary Center in Southern India. ( 24131076 )
2013
37
Sympathetic ophthalmia following enucleation. ( 22124788 )
2013
38
Reversible alopecia in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. ( 23514340 )
2013
39
High definition spectral domain optical coherence tomography of retinal pigment epithelial rip in a case of sympathetic ophthalmia. ( 23514588 )
2013
40
Incidence of hypotony and sympathetic ophthalmia following trans-scleral cyclophotocoagulation for glaucoma and a report of risk factors. ( 23433313 )
2013
41
Missed perforation presenting as sympathetic ophthalmia in an adolescent Malay girl. ( 22914237 )
2012
42
Continued vision loss from progressive expansion of inactive chorioretinal scars in a myopic patient with well-controlled sympathetic ophthalmia. ( 25389936 )
2012
43
Presumed occult globe rupture resulting in sympathetic ophthalmia. ( 22200914 )
2012
44
Expression of I+-crystallin in the retina of human sympathetic ophthalmia. ( 22052021 )
2012
45
Update on sympathetic ophthalmia. ( 22346110 )
2012
46
Immunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling. ( 22589448 )
2012
47
Sympathetic ophthalmia in HIV infection. A clinicopathological case report. ( 22411458 )
2012
48
Imaging for sympathetic ophthalmia: impact on the diagnosis and management. ( 22954939 )
2012
49
Multimodality diagnostic imaging in a case of sympathetic ophthalmia. ( 22594960 )
2012
50
Mitochondrial oxidative stress initiates visual loss in sympathetic ophthalmia. ( 22476625 )
2012

Variations for Sympathetic Ophthalmia

Expression for Sympathetic Ophthalmia

Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for Sympathetic Ophthalmia

Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA PDCD1
2
Show member pathways
13.13 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 PDCD1
3
Show member pathways
13.02 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
4
Show member pathways
12.41 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
5
Show member pathways
12.38 HLA-C LTA TNF
6
Show member pathways
12.37 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
7 12.31 CTLA4 PDCD1 TNF
8
Show member pathways
12.28 HLA-C HLA-DQA1 HLA-DRB1
9
Show member pathways
12.2 HLA-DQA1 HLA-DRB1 TNF
10
Show member pathways
12.18 CTLA4 PDCD1 TNF
11
Show member pathways
12.14 CTLA4 HLA-DQA1 HLA-DRB1
12 12.03 HLA-C HLA-DQA1 HLA-DRB1
13
Show member pathways
11.98 HLA-DQA1 HLA-DRB1 TNF
14 11.95 HLA-DQA1 HLA-DRB1 TNF
15
Show member pathways
11.91 CTLA4 HLA-DQA1 HLA-DRB1 PDCD1
16 11.84 HLA-C HLA-DQA1 HLA-DRB1
17 11.76 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
18
Show member pathways
11.67 HLA-DQA1 HLA-DRB1 PDCD1
19 11.6 HLA-DQA1 HLA-DRB1 TNF
20 11.51 CTLA4 HLA-DQA1 HLA-DRB1 TNF
21 11.43 CTLA4 HLA-DQA1 HLA-DRB1
22 11.4 CTLA4 PDCD1
23 11.38 HLA-DQA1 HLA-DRB1
24 11.36 LTA TNF
25
Show member pathways
11.32 LTA TNF
26 11.18 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 PDCD1
27 11.07 CTLA4 PDCD1
28 11.04 HLA-DRB1 TNF

GO Terms for Sympathetic Ophthalmia

Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA PDCD1
2 external side of plasma membrane GO:0009897 9.46 CTLA4 HLA-DRB1 PDCD1 TNF
3 transport vesicle membrane GO:0030658 9.4 HLA-DQA1 HLA-DRB1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.32 HLA-DQA1 HLA-DRB1
5 MHC class II protein complex GO:0042613 9.26 HLA-DQA1 HLA-DRB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-C HLA-DQA1 HLA-DRB1
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-C HLA-DQA1 HLA-DRB1

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.8 CTLA4 HLA-C HLA-DQA1 HLA-DRB1
2 positive regulation of apoptotic process GO:0043065 9.73 CTLA4 LTA PDCD1 TNF
3 interferon-gamma-mediated signaling pathway GO:0060333 9.58 HLA-C HLA-DQA1 HLA-DRB1
4 humoral immune response GO:0006959 9.54 LTA PDCD1 TNF
5 positive regulation of interferon-gamma production GO:0032729 9.52 LTA TNF
6 negative regulation of T cell proliferation GO:0042130 9.51 CTLA4 HLA-DRB1
7 negative regulation of growth of symbiont in host GO:0044130 9.48 LTA TNF
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.46 HLA-DQA1 HLA-DRB1
9 antigen processing and presentation GO:0019882 9.43 HLA-C HLA-DQA1 HLA-DRB1
10 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.32 LTA TNF
11 T cell costimulation GO:0031295 9.26 CTLA4 HLA-DQA1 HLA-DRB1 PDCD1
12 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 LTA TNF
13 immune response GO:0006955 9.1 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF

Molecular functions related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.16 LTA TNF
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQA1 HLA-DRB1
3 peptide antigen binding GO:0042605 8.8 HLA-C HLA-DQA1 HLA-DRB1

Sources for Sympathetic Ophthalmia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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