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MCID: SYN003
MIFTS: 27

Synchronous Bilateral Breast Carcinoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Synchronous Bilateral Breast Carcinoma

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MalaCards integrated aliases for Synchronous Bilateral Breast Carcinoma:

Name: Synchronous Bilateral Breast Carcinoma 12 15 71

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6742
NCIt 49 C40370
UMLS 71 C1515107
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Summaries for Synchronous Bilateral Breast Carcinoma

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MalaCards based summary : Synchronous Bilateral Breast Carcinoma is related to bilateral breast cancer and in situ carcinoma. An important gene associated with Synchronous Bilateral Breast Carcinoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Chks in Checkpoint Regulation. Affiliated tissues include breast, ovary and b cells, and related phenotypes are Increased homologous recombination repair frequency and Increased homologous recombination repair frequency

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Related Diseases for Synchronous Bilateral Breast Carcinoma

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Diseases related to Synchronous Bilateral Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 bilateral breast cancer 29.7 PGR BRCA2 BRCA1
2 in situ carcinoma 29.2 PGR BRCA2 BRCA1
3 ductal carcinoma in situ 29.2 PGR BRCA2 BRCA1
4 cowden syndrome 29.1 BRCA2 BRCA1
5 sporadic breast cancer 29.0 PGR BRCA2 BRCA1
6 breast ductal carcinoma 28.9 PGR BRCA2 BRCA1
7 breast cancer 10.4
8 lymphoma, hodgkin, classic 9.9
9 lymphoma, non-hodgkin, familial 9.9
10 diffuse large b-cell lymphoma 9.9
11 follicular lymphoma 9.9
12 b-cell lymphoma 9.9
13 luminal breast carcinoma 9.7 PGR BRCA1
14 hereditary site-specific ovarian cancer syndrome 9.7 BRCA2 BRCA1
15 estrogen-receptor negative breast cancer 9.7 PGR BRCA1
16 breast fibroadenoma 9.7 PGR BRCA1
17 rare malignant breast tumor 9.7 BRCA2 BRCA1
18 cystadenoma 9.7 PGR BRCA1
19 familial ovarian cancer 9.7 BRCA2 BRCA1
20 tetraploidy 9.7 BRCA2 BRCA1
21 cancerophobia 9.7 BRCA2 BRCA1
22 nosophobia 9.7 BRCA2 BRCA1
23 breast-ovarian cancer, familial 2 9.7 BRCA2 BRCA1
24 breast-ovarian cancer, familial 1 9.7 BRCA2 BRCA1
25 mutagen sensitivity 9.7 BRCA2 BRCA1
26 estrogen-receptor positive breast cancer 9.7 PGR BRCA1
27 dysplastic nevus syndrome 9.7 BRCA2 BRCA1
28 peritoneum cancer 9.7 BRCA2 BRCA1
29 premature menopause 9.7 BRCA2 BRCA1
30 fallopian tube disease 9.6 BRCA2 BRCA1
31 fanconi anemia, complementation group d1 9.6 BRCA2 BRCA1
32 myasthenic syndrome, congenital, 6, presynaptic 9.6 BRCA2 BRCA1
33 fanconi anemia, complementation group j 9.6 BRCA2 BRCA1
34 ovarian cystadenocarcinoma 9.6 BRCA2 BRCA1
35 dysgerminoma 9.6 BRCA2 BRCA1
36 congenital hypoplastic anemia 9.6 BRCA2 BRCA1
37 bloom syndrome 9.5 BRCA2 BRCA1
38 hereditary breast ovarian cancer syndrome 9.5 BRCA2 BRCA1
39 cowden syndrome 1 9.5 BRCA2 BRCA1
40 breast juvenile papillomatosis 9.4 PGR BRCA2 BRCA1
41 endosalpingiosis 9.4 PGR BRCA2 BRCA1
42 primary peritoneal carcinoma 9.4 PGR BRCA2 BRCA1
43 intracystic papillary adenoma 9.4 PGR BRCA2 BRCA1
44 hypertrophy of breast 9.4 PGR BRCA2 BRCA1
45 female reproductive endometrioid cancer 9.4 PGR BRCA2 BRCA1
46 papillary serous adenocarcinoma 9.4 PGR BRCA2 BRCA1
47 lobular neoplasia 9.4 PGR BRCA2 BRCA1
48 autosomal recessive cerebellar ataxia 9.4 BRCA2 BRCA1
49 thoracic benign neoplasm 9.4 PGR BRCA2 BRCA1
50 breast benign neoplasm 9.4 PGR BRCA2 BRCA1

Graphical network of the top 20 diseases related to Synchronous Bilateral Breast Carcinoma:



Diseases related to Synchronous Bilateral Breast Carcinoma
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Symptoms & Phenotypes for Synchronous Bilateral Breast Carcinoma

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GenomeRNAi Phenotypes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased homologous recombination repair frequency GR00236-A-1 9.7 BRCA1 BRCA2 PGR
2 Increased homologous recombination repair frequency GR00236-A-2 9.7 APPL1 BRCA1 BRCA2 PGR
3 Increased cell death HMECs cells GR00103-A-0 9.43 BABAM2 BRCA1 PGR
4 Decreased viability after ionizing radiation GR00232-A-2 9.37 BRCA1 BRCA2
5 Decreased viability with cisplatin GR00101-A-4 9.32 BRCA1 BRCA2
6 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.13 BABAM2 BRCA1 BRCA2
7 Synthetic lethal with cisplatin GR00101-A-1 8.62 BRCA1 BRCA2

MGI Mouse Phenotypes related to Synchronous Bilateral Breast Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 APPL1 BABAM2 BRCA1 BRCA2 PGR
2 cellular MP:0005384 9.02 APPL1 BABAM2 BRCA1 BRCA2 PGR
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Drugs & Therapeutics for Synchronous Bilateral Breast Carcinoma

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Search Clinical Trials , NIH Clinical Center for Synchronous Bilateral Breast Carcinoma

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Genetic Tests for Synchronous Bilateral Breast Carcinoma

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Anatomical Context for Synchronous Bilateral Breast Carcinoma

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MalaCards organs/tissues related to Synchronous Bilateral Breast Carcinoma:

40
Breast, Ovary, B Cells
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Publications for Synchronous Bilateral Breast Carcinoma

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Articles related to Synchronous Bilateral Breast Carcinoma:

(show all 14)
# Title Authors PMID Year
1
Radiation therapy of synchronous bilateral breast carcinoma (SBBC) using multiple techniques. 61
28988893 2018
2
EVOLUTION OF SYNCHRONOUS BILATERAL BREAST CARCINOMA IN A YOUNG PATIENT. 61
27125095 2016
3
Periductal stromal tumor of the breast with synchronous bilateral breast cancer. 61
24982380 2014
4
Synchronous bilateral breast carcinoma and axillary non-hodgkin lymphoma: a case report and review of the literature. 61
23050177 2012
5
Synchronous bilateral breast carcinoma with two different morphology subtypes: a case report. 61
20698158 2010
6
Synchronous bilateral breast carcinoma in a patient with cowden syndrome: a case report with morphologic, immunohistochemical and genetic analysis. 61
19968660 2010
7
Diagnostic and prognostic utility of molecular markers in synchronous bilateral breast carcinoma. 61
18469799 2008
8
Clinicopathological characteristics of synchronous bilateral breast carcinomas. Report of 30 patients. 61
18444533 2008
9
[Synchronous bilateral breast cancer: risk factors, diagnosis, histology and treatment]. 61
18178120 2008
10
Synchronous bilateral breast carcinoma in a 50-year-old man with 45,X/46,XY mosaic karyotype: report of a case. 61
16378198 2006
11
Molecular study of clonality in multifocal and bilateral breast tumors. 61
15648612 2004
12
Histological grade, p53, HER2 and hormone receptor status of synchronous bilateral breast carcinoma. 61
12016392 2002
13
Bilateral breast carcinoma: risk factors and outcomes for patients with synchronous and metachronous disease. 61
10870056 2000
14
Breast-conserving therapy for stage I-II synchronous bilateral breast carcinoma. 61
9083159 1997
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Variations for Synchronous Bilateral Breast Carcinoma

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Expression for Synchronous Bilateral Breast Carcinoma

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Search GEO for disease gene expression data for Synchronous Bilateral Breast Carcinoma.
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Pathways for Synchronous Bilateral Breast Carcinoma

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Pathways related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Gastric cancer 36
Show member pathways
 12.21 PGR BRCA2 BRCA1
2
Chks in Checkpoint Regulation 63
Show member pathways
 12.11 BRCA2 BRCA1 BABAM2
3
DNA Damage 4
11.6 BRCA2 BRCA1 BABAM2
4
Fanconi anemia pathway 36 65
11.4 BRCA2 BRCA1
5
BRCA1 Pathway 63
Show member pathways
 11.32 BRCA2 BRCA1
6
Coregulation of Androgen receptor activity 1
11.01 BRCA1 APPL1
7
Resolution of D-loop Structures through Holliday Junction Intermediates 65
Show member pathways
 10.98 BRCA2 BRCA1 BABAM2
8
Metalloprotease DUBs 65
10.74 BRCA1 BABAM2
Sources

GO Terms for Synchronous Bilateral Breast Carcinoma

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Cellular components related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral element GO:0000800 8.96 BRCA2 BRCA1
2 BRCA1-A complex GO:0070531 8.62 BRCA1 BABAM2

Biological processes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.67 BRCA2 BRCA1 BABAM2
2 DNA repair GO:0006281 9.58 BRCA2 BRCA1 BABAM2
3 cell cycle GO:0007049 9.56 BRCA2 BRCA1 BABAM2 APPL1
4 DNA recombination GO:0006310 9.52 BRCA2 BRCA1
5 double-strand break repair via homologous recombination GO:0000724 9.51 BRCA2 BRCA1
6 double-strand break repair via nonhomologous end joining GO:0006303 9.48 BRCA1 BABAM2
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.46 BRCA2 BRCA1
8 response to ionizing radiation GO:0010212 9.43 BRCA1 BABAM2
9 positive regulation of DNA repair GO:0045739 9.37 BRCA1 BABAM2
10 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 BRCA2 BRCA1
11 signal transduction involved in G2 DNA damage checkpoint GO:0072425 9.16 BRCA1 BABAM2
12 chordate embryonic development GO:0043009 8.96 BRCA2 BRCA1
13 double-strand break repair GO:0006302 8.8 BRCA2 BRCA1 BABAM2

Molecular functions related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 PGR BRCA2 BRCA1 APPL1
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Sources for Synchronous Bilateral Breast Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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