Synchronous Bilateral Breast Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SYN003 MIFTS: 40	Synchronous Bilateral Breast Carcinoma Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Synchronous Bilateral Breast Carcinoma

MalaCards integrated aliases for Synchronous Bilateral Breast Carcinoma:

Name: Synchronous Bilateral Breast Carcinoma ¹² ¹⁵ ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6742

NCIt ⁵¹ C40370

UMLS ⁷⁴ C1515107

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Summaries for Synchronous Bilateral Breast Carcinoma

MalaCards based summary : Synchronous Bilateral Breast Carcinoma is related to lymphoma, non-hodgkin, familial and pancreatic neuroendocrine tumor. An important gene associated with Synchronous Bilateral Breast Carcinoma is ATM (ATM Serine/Threonine Kinase), and among its related pathways/superpathways are Gene Expression and Cell Cycle, Mitotic. The drugs Letrozole and Sodium Citrate have been mentioned in the context of this disorder. Affiliated tissues include bone and breast, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

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Related Diseases for Synchronous Bilateral Breast Carcinoma

Diseases related to Synchronous Bilateral Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)

#	Related Disease	Score	Top Affiliating Genes
1	lymphoma, non-hodgkin, familial	29.4	ATM CCND1 TP53
2	pancreatic neuroendocrine tumor	10.3	ATM BRCA2
3	breast duct papilloma	10.3	PGR PTEN
4	clivus chordoma	10.3	ATM PTEN
5	endometrium carcinoma in situ	10.2	PGR TP53
6	myxosarcoma	10.2	ATM TP53
7	corneal abscess	10.2	PGR PTEN
8	breast malignant phyllodes tumor	10.2	PGR TP53
9	ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	10.2	PTEN TP53
10	richter's syndrome	10.2	ATM TP53
11	olfactory groove meningioma	10.2	PGR TP53
12	gliomatosis cerebri	10.2	PTEN TP53
13	uterine body mixed cancer	10.2	PGR TP53
14	bartholin's gland disease	10.2	PGR TP53
15	microglandular adenosis	10.2	PGR TP53
16	hereditary site-specific ovarian cancer syndrome	10.2	BRCA1 BRCA2
17	anterior cranial fossa meningioma	10.2	PGR TP53
18	breast giant fibroadenoma	10.2	BRCA2 ESR1
19	vestibular gland benign neoplasm	10.2	ESR1 PGR
20	bartholin's gland adenoma	10.2	ESR1 PGR
21	tuberculous salpingitis	10.2	BRCA1 BRCA2
22	vulvar syringoma	10.2	ESR1 PGR
23	lung leiomyoma	10.2	ESR1 PGR
24	glassy cell carcinoma of the cervix	10.2	ESR1 PGR
25	breast reconstruction	10.2	BRCA1 BRCA2
26	vulvar benign neoplasm	10.2	ESR1 PGR
27	trigonitis	10.2	ESR1 PGR
28	vulvar leiomyoma	10.2	ESR1 PGR
29	breast-ovarian cancer, familial 1	10.2	BRCA1 BRCA2
30	predominantly cortical thymoma	10.2	ESR1 PGR
31	acinar cell carcinoma	10.2	BRCA2 TP53
32	breast scirrhous carcinoma	10.2	ESR1 PGR
33	bartholin's gland benign neoplasm	10.2	ESR1 PGR
34	oncocytic breast carcinoma	10.2	ESR1 PGR
35	fallopian tube adenocarcinoma	10.2	BRCA1 BRCA2
36	progesterone-receptor positive breast cancer	10.2	ESR1 PGR
37	progesterone resistance	10.2	ESR1 PGR
38	cribriform carcinoma	10.2	ESR1 PGR
39	endometrial mucinous adenocarcinoma	10.2	ESR1 PGR
40	adenoid basal cell carcinoma	10.2	ESR1 PGR
41	apocrine adenocarcinoma	10.2	ESR1 PGR
42	peritoneal benign neoplasm	10.1	ESR1 PGR
43	gender identity disorder	10.1	ESR1 PGR
44	deep angioma	10.1	ESR1 PGR
45	diffuse peritoneal leiomyomatosis	10.1	ESR1 PGR
46	breast adenoid cystic carcinoma	10.1	ESR1 PGR
47	estrogen excess	10.1	ESR1 PGR
48	intramuscular hemangioma	10.1	ESR1 PGR
49	mammographic density	10.1	ESR1 PGR
50	cervical clear cell adenocarcinoma	10.1	ESR1 PGR

Graphical network of the top 20 diseases related to Synchronous Bilateral Breast Carcinoma:

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Symptoms & Phenotypes for Synchronous Bilateral Breast Carcinoma

GenomeRNAi Phenotypes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

²⁷ (show all 14)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased homologous recombination repair frequency	GR00151-A-1	10.2	BRCA1
2	Decreased homologous recombination repair frequency	GR00151-A-2	10.2	BRCA1
3	Decreased homologous recombination repair frequency	GR00236-A-1	10.2	BRCA1 BRCA2 PGR
4	Decreased homologous recombination repair frequency	GR00236-A-2	10.2	ATM BRCA1 BRCA2 PGR
5	Decreased homologous recombination repair frequency	GR00236-A-3	10.2	BRCA1 BRCA2
6	Decreased viability in esophageal squamous lineage	GR00235-A	9.97	BRCA1 BRCA2 CCND1 ESR1 PGR PTEN
7	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.64	ATM BRCA1 BRCA2 PTEN TP53
8	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.64	ATM BRCA1 BRCA2 PTEN TP53 CCND1
9	Increased cell death HMECs cells	GR00103-A-0	9.62	BRCA1 PGR PTEN TP53
10	Decreased viability after ionizing radiation	GR00232-A-2	9.58	ATM BRCA1 BRCA2
11	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.46	ATM BRCA1 BRCA2 TP53
12	Decreased TP53 mRNA expression	GR00389-S-5	9.43	ATM TP53
13	Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)	GR00104-A-0	9.43	CCND1 ESR1 PTEN
14	Synthetic lethal with cisplatin	GR00101-A-1	8.96	BRCA1 BRCA2

MGI Mouse Phenotypes related to Synchronous Bilateral Breast Carcinoma:

⁴⁷ (show all 21)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.24	ATM BRCA1 BRCA2 CCND1 ESR1 PGR
2	endocrine/exocrine gland	MP:0005379	10.2	ATM BRCA1 BRCA2 CCND1 ESR1 PGR
3	cardiovascular system	MP:0005385	10.19	ATM BRCA1 CCND1 ESR1 PGR PTEN
4	cellular	MP:0005384	10.18	ATM BRCA1 BRCA2 CCND1 ESR1 PGR
5	hematopoietic system	MP:0005397	10.18	ATM BRCA1 BRCA2 CCND1 ESR1 PGR
6	homeostasis/metabolism	MP:0005376	10.16	ATM BRCA1 BRCA2 CCND1 ESR1 PGR
7	immune system	MP:0005387	10.15	ATM BRCA1 BRCA2 CCND1 ESR1 PGR
8	integument	MP:0010771	10.13	ATM BRCA1 BRCA2 CCND1 ESR1 PGR
9	digestive/alimentary	MP:0005381	10.11	BRCA1 BRCA2 CCND1 ESR1 PTEN SLC5A7
10	embryo	MP:0005380	10.1	ATM BRCA1 BRCA2 ESR1 PGR PTEN
11	mortality/aging	MP:0010768	10.09	ATM BRCA1 BRCA2 CCND1 ESR1 PGR
12	growth/size/body region	MP:0005378	10.08	ATM BRCA1 BRCA2 CCND1 ESR1 PTEN
13	adipose tissue	MP:0005375	10	ATM BRCA1 ESR1 PTEN TP53
14	neoplasm	MP:0002006	9.97	ATM BRCA1 BRCA2 CCND1 ESR1 PGR
15	limbs/digits/tail	MP:0005371	9.93	BRCA1 BRCA2 ESR1 PGR PTEN TP53
16	nervous system	MP:0003631	9.92	ATM BRCA1 BRCA2 CCND1 ESR1 PTEN
17	normal	MP:0002873	9.86	BRCA1 BRCA2 CCND1 ESR1 PGR PTEN
18	muscle	MP:0005369	9.8	BRCA1 ESR1 PGR PTEN TP53
19	reproductive system	MP:0005389	9.76	ATM BRCA1 BRCA2 CCND1 ESR1 PGR
20	respiratory system	MP:0005388	9.43	BRCA1 CCND1 ESR1 PTEN SLC5A7 TP53
21	skeleton	MP:0005390	9.17	BRCA1 BRCA2 CCND1 ESR1 PGR PTEN

Sources

Drugs & Therapeutics for Synchronous Bilateral Breast Carcinoma

Drugs for Synchronous Bilateral Breast Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Letrozole

Approved, Investigational

Phase 3

112809-51-5

3902

Synonyms:

1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole

1-[Bis-(4-cyanophenyl)methyl]-1,2,4-triazole

112809-51-5

4,4'-((1h-1,2,4-triazol-1-yl)methylene)dibenzonitrile

4,4'-(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitrile

4,4'-(1h-1,2,4-triazol-1-ylmethylene) bis-benzonitrile

4,4'-(1H-1,2,4-triazol-1-yl-methylene)-bis(benzonitrile)

4,4'-(1H-1,2,4-Triazol-1-yl-methylene)-bis(benzonitrile)

4,4'-(1h-1,2,4-triazol-1-ylmethylene)bisbenzonitrile

4,4'-(1h-1,2,4-triazol-1-ylmethylene)bis-benzonitrile

4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-Benzonitrile Letrozole

4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile

4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile

AB00514009

AC-1193

AC1L1GYT

AKOS005145822

BIDD:GT0015

BIDD:PXR0130

Bio-0057

BPBio1_001331

BRD-K88789588-001-03-2

BSPBio_001209

C067431

C08163

C17H11N5

CAS-112809-51-5

CCRIS 8822

CGS 20267

CGS 20267, Femara, Piroxicam, Letrozole

CGS-20267

CHEBI:6413

CHEMBL1444

CID3902

CPD000466343

D00964

DB01006

FEM-345

Femara

Fémara

Femara (TN)

Femera

HMS1571M11

HMS2051E08

HMS2089L22

HSDB 7461

I06-0022

Letoval

Letrozol

letrozole

Letrozole

Letrozole (JAN/USP/INN)

Letrozole [USAN:INN]

LS-38788

MLS000759455

MLS001424038

MLS002584991

MolPort-003-848-373

NCGC00016973-01

NCGC00016973-02

Novartis brand OF letrozole

Novartis Brand of Letrozole

NSC719345

Prestwick0_001025

Prestwick1_001025

Prestwick2_001025

Prestwick3_001025

S1235_Selleck

SAM001246649

SMR000466343

SPBio_003070

TL8000371

UNII-7LKK855W8I

ZINC03778874

Sodium Citrate

Approved, Investigational

Phase 3

68-04-2

Synonyms:

Anhydrous sodium citrate

Anhydrous trisodium citrate

Citric acid, trisodium salt

Natrii citras

Natrocitral

Sodium citrate anhydrous

Sodium citrate, anhydrous

Sodium citrate,anhydrous

trisodium citrate anhydrous

Trisodium citrate, anhydrous

Trisodium-citrate

Anastrozole

Approved, Investigational

Phase 3

120511-73-1

2187

Synonyms:

.alpha.,alpha.,.alpha.',.alpha.'-tetramethyl-5(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile

1,3-benzenediacetonitrile, a, a, a', a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)

120511-73-1

2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropionitrile)

2,2'-(5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropionitrile)

2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile)

2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)benzene-1,3-diyl]bis(2-methylpropanenitrile)

2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile

a,a,Alpha',alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile

AC1L1D49

AC-4234

alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile

alpha,alpha,Alpha',alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile

anastrazole

Anastrazole

Anastrole

Anastrozol

anastrozole

Anastrozole

Anastrozole (JAN/USAN/INN)

Anastrozole [USAN:INN:BAN]

Arimidex

Arimidex (TN)

Arimidex (Zeneca)

Arimidex, Anastrozole

Asiolex

Astra brand of anastrozole

Astra brand OF anastrozole

AstraZeneca brand of anastrozole

AstraZeneca brand OF anastrozole

C08159

C090450

C17H19N5

CHEBI:2704

CHEMBL1399

CID2187

CPD000466301

D00960

DB01217

HMS2052M11

HMS2089N10

HSDB 7462

I06-0021

ICI D1033

ICI-D 1033

ICI-D1033

LS-29563

MLS000759396

MLS001424217

MolPort-005-933-078

NCGC00164619-01

NSC719344

S1188_Selleck

SAM001246525

SBB066057

SMR000466301

UNII-2Z07MYW1AZ

ZD 1033

ZD1033

ZD-1033

Zeneca brand of anastrozole

Zeneca brand OF anastrozole

Zeneca ZD 1033

ZINC00000941

α,α,alpha',alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile

α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile

Exemestane

Approved, Investigational

Phase 3

107868-30-4

60198

Synonyms:

(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione

107868-30-4

6-Methylenandrosta-1,4-diene-3,17-dione

6-methyleneandrosta-1,4-diene-3,17-dione

6-Methyleneandrosta-1,4-diene-3,17-dione

6-methylideneandrosta-1,4-diene-3,17-dione

AC1L1SRB

AC1Q6AAZ

AC-2171

Ambap107868-30-4

Aromasil

Aromasin

Aromasin (TN)

Aromasin, Exemestane

Aromasine

C056516

C08162

CHEBI:4953

CHEMBL1200374

CID60198

CPD000466314

Curator_000009

D00963

DB00990

Examestane

EXE

Exemestance

exemestane

Exemestane

EXEMESTANE

Exemestane (JAN/USP/INN)

Exemestane [USAN:INN:BAN]

Exemestano

Exemestano [INN-Spanish]

Exemestanum

Exemestanum [INN-Latin]

Fce 24304

FCE-24304

HMS2051J04

HSDB 7463

LS-19329

MLS000759419

MLS001424062

MolPort-003-847-343

Nikidess

NSC713563

Pfizer brand of exemestane

PNU-155971

S1196_Selleck

S1196_Sellek

SAM001246574

SMR000466314

UNII-NY22HMQ4BX

ZINC03973334

Tamoxifen

Approved

Phase 3

10540-29-1

2733526

Synonyms:

(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene

(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine

(Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethanamine

(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine

(Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine

(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC)

(Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE

(Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine

,citrate

10540-29-1

1-p-.beta.-Dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene

1-Para-b-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

1-Para-β-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

1-P-b-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

1-P-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

1-P-β-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

1ya4

2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine

54965-24-1 (citrate)

AC1MBZ3R

apo-Tamox

Apo-Tamox

BIDD:ER0008

BIDD:GT0009

BIDD:PXR0003

BPBio1_000278

BRD-K93754473-001-02-9

BRD-K93754473-048-05-3

BSPBio_000252

BSPBio_001150

BSPBio_001982

C07108

C26H29NO

CCRIS 3275

CHEBI:41774

CHEMBL83

CID2733526

Citofen

Citrate, tamoxifen

cMAP_000044

Crisafeno

D08559

DB00675

Diemon

EINECS 234-118-0

Gen-tamoxifen

Gen-Tamoxifen

HMS1362J11

HMS1792J11

HMS1990J11

HMS2090N08

HSDB 6782

ICI 47699

ICI-46,474

ICI-47699

IDI1_000258

IDI1_002170

Istubol

Kessar

L024126

Lopac0_001203

LS-393

MLS001332535

MLS001332536

MolPort-003-850-384

NCGC00024928-01

NCGC00024928-03

NCGC00024928-04

NCGC00024928-05

NCGC00024928-07

NCGC00024928-08

NCGC00024928-09

NCGC00024928-12

nchembio.140-comp7

nchembio.76-comp1

nchembio732-comp3

Noltam

Nolvadex

Nolvadex-D

Nourytam

Novaldex

Novo-Tamoxifen

NSC727681

Oncomox

Pms-Tamoxifen

PMS-Tamoxifen

Prestwick2_000146

Prestwick3_000146

QTL1_000079

Retaxim

Savient brand OF tamoxifen citrate

SMR000059172

Soltamox

Spectrum5_001417

Spectrum5_002043

ST50511785

T5648_SIGMA

Tamizam

Tamofen

Tamone

Tamoplex (TN)

Tamoxasta

Tamoxen

tamoxifen

Tamoxifen

Tamoxifen (INN)

TAMOXIFEN (TAMOXIFEN CITRATE (54965-24-1))

Tamoxifen (TN)

Tamoxifen (Z)

Tamoxifen [INN:BAN]

Tamoxifen and its salts

Tamoxifen citrate

Tamoxifen Citrate

Tamoxifene

Tamoxifène

Tamoxifene [INN-French]

Tamoxifeno

Tamoxifeno [INN-Spanish]

Tamoxifenum

Tamoxifenum [INN-Latin]

Tocris-0999

Tomaxithen

TRANS FORM OF TAMOXIFEN

trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine

trans-Tamoxifen

Trans-Tamoxifen

UNII-094ZI81Y45

UPCMLD-DP027

Valodex

Zemide

Zitazonium

Citric Acid

Approved, Nutraceutical, Vet_approved

Phase 3

77-92-9

311

Synonyms:

2-hydroxy-1,2,3-propanetricarboxyic acid

2-Hydroxy-1,2,3-propanetricarboxylate

2-Hydroxy-1,2,3-propanetricarboxylic acid

2-Hydroxytricarballylate

2-Hydroxytricarballylic acid

3-Carboxy-3-hydroxypentane-1,5-dioate

3-carboxy-3-hydroxypentane-1,5-dioic acid

3-Carboxy-3-hydroxypentane-1,5-dioic acid

Acid monohydrate, citric

ácido cítrico

Acidum citricum

Aciletten

Anhydrous citrate

Anhydrous citric acid

beta-Hydroxytricarballylate

beta-Hydroxytricarballylic acid

Chemfill

Citraclean

Citrate

Citretten

Citric acid monoglyceride

Citric acid monohydrate

Citric acid, anhydrous

Citric Acid, Anhydrous

Citric acid,anhydrous

Citro

Citronensaeure

Citronensäure

e 330

e330

H3Cit

Hydrocerol a

Kyselina citronova

Monohydrate, citric acid

Suby g

Uralyt u

uro-Trainer

Calcium

Approved, Nutraceutical

Phase 3

7440-70-2

271

Synonyms:

Blood coagulation factor XIII

Ca(2+)

Ca2+

Calcio

Calcium

Calcium element

CALCIUM ion

Calcium, doubly charged positive ion

Calcium, elemental

Coagulation factor XIII

Elemental calcium

Factor XIII

Factor XIII a chain

Factor XIII a-chain

Factor XIII transamidase

Factor XIII, coagulation

Fibrin stabilizing factor

Fibrinase

Kalzium

Laki lorand factor

Laki-lorand factor

Stabilizing factor, fibrin

Transamidase, factor XIII

XIII, coagulation factor

Bone Density Conservation Agents

Phase 3

Aromatase Inhibitors

Phase 3

Estrogen Receptor Antagonists

Phase 3

Estrogen Antagonists

Phase 3

Hormones

Phase 3

Chelating Agents

Phase 3

Steroid Synthesis Inhibitors

Phase 3

Antineoplastic Agents, Hormonal

Phase 3

Hormone Antagonists

Phase 3

Selective Estrogen Receptor Modulators

Phase 3

Citrate

Phase 3

Anticoagulants

Phase 3

Calcium, Dietary

Phase 3

Estrogens

Phase 3

Estrogen Receptor Modulators

Phase 3

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer	Active, not recruiting	NCT01272037	Phase 3	Anastrozole;Exemestane;Letrozole;Systemic Chemotherapy;Tamoxifen Citrate

Search NIH Clinical Center for Synchronous Bilateral Breast Carcinoma

Sources

Genetic Tests for Synchronous Bilateral Breast Carcinoma

Sources

Anatomical Context for Synchronous Bilateral Breast Carcinoma

MalaCards organs/tissues related to Synchronous Bilateral Breast Carcinoma:

⁴²

Bone, Breast

Sources

Publications for Synchronous Bilateral Breast Carcinoma

Articles related to Synchronous Bilateral Breast Carcinoma:

#	Title	Authors	Year
1	Radiation therapy of synchronous bilateral breast carcinoma (SBBC) using multiple techniques. ( 28988893 )	Kim S.J....Youn S.M.	2018
2	EVOLUTION OF SYNCHRONOUS BILATERAL BREAST CARCINOMA IN A YOUNG PATIENT. ( 27125095 )	Manea E....Munteanu A.	2016
3	Synchronous bilateral breast carcinoma and axillary non-hodgkin lymphoma: a case report and review of the literature. ( 23050177 )	Miles E.F....Jacimore L.L.	2012
4	Synchronous bilateral breast carcinoma in a patient with cowden syndrome: a case report with morphologic, immunohistochemical and genetic analysis. ( 19968660 )	PeirA^ G....CatasA_s L.	2010
5	Synchronous bilateral breast carcinoma with two different morphology subtypes: a case report. ( 20698158 )	Branica B.V....Krizanac S.	2010
6	Diagnostic and prognostic utility of molecular markers in synchronous bilateral breast carcinoma. ( 18469799 )	Saad R.S....Silverman J.F.	2008
7	Synchronous bilateral breast carcinoma in a 50-year-old man with 45,X/46,XY mosaic karyotype: report of a case. ( 16378198 )	Franceschini G....Picciocchi A.	2006
8	Histological grade, p53, HER2 and hormone receptor status of synchronous bilateral breast carcinoma. ( 12016392 )	Matsuo K....Tsuda H.	2002
9	Breast-conserving therapy for stage I-II synchronous bilateral breast carcinoma. ( 9083159 )	Gollamudi S.V....Connolly J.L.	1997

Sources

Genes for Synchronous Bilateral Breast Carcinoma

Genes related to Synchronous Bilateral Breast Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ATM	ATM Serine/Threonine Kinase	Protein Coding	13.75	DISEASES inferred ¹⁵
2	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	13.51	DISEASES inferred ¹⁵
3	PTEN	Phosphatase And Tensin Homolog	Protein Coding	13.42	DISEASES inferred ¹⁵
4	TP53	Tumor Protein P53	Protein Coding	13.37	DISEASES inferred ¹⁵
5	PGR	Progesterone Receptor	Protein Coding	13.32	DISEASES inferred ¹⁵
6	SLC5A7	Solute Carrier Family 5 Member 7	Protein Coding	13.31	DISEASES inferred ¹⁵
7	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	13.23	DISEASES inferred ¹⁵
8	CCND1	Cyclin D1	Protein Coding	13.19	DISEASES inferred ¹⁵
9	ESR1	Estrogen Receptor 1	Protein Coding	13.07	DISEASES inferred ¹⁵

Sources

Variations for Synchronous Bilateral Breast Carcinoma

Sources

Expression for Synchronous Bilateral Breast Carcinoma

Search GEO for disease gene expression data for Synchronous Bilateral Breast Carcinoma.

Sources

Pathways for Synchronous Bilateral Breast Carcinoma

Pathways related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 57)

#	Super pathways	Score	Top Affiliating Genes
1	Gene Expression ⁶⁷ Show member pathways Generic Transcription Pathway ⁶⁷	13.63	ATM BRCA1 ESR1 PGR PTEN TP53
2	Cell Cycle, Mitotic ⁶⁷ Show member pathways Cell Cycle ⁶⁷ M Phase ⁶⁷	13.27	ATM BRCA1 BRCA2 CCND1 TP53
3	PI3K-Akt signaling pathway ³⁸ Show member pathways Human papillomavirus infection ³⁸	12.87	ATM BRCA1 CCND1 PTEN TP53
4	Human cytomegalovirus infection ³⁸ Show member pathways Human immunodeficiency virus 1 infection ³⁸ Kaposi sarcoma-associated herpesvirus infection ³⁸	12.82	ATM CCND1 PTEN TP53
5	Regulation of TP53 Activity ⁶⁷ Show member pathways Regulation of TP53 Activity through Association with Co-factors ⁶⁷ Regulation of TP53 Activity through Methylation ⁶⁷ Regulation of TP53 Activity through Phosphorylation ⁶⁷ Transcriptional Regulation by TP53 ⁶⁷	12.82	ATM BRCA1 PTEN TP53
6	TCR Signaling (Qiagen) ⁶⁵ Show member pathways Fc-EpsilonRI Pathway ⁶⁵ PDGF Pathway ⁶⁵ PKC-Theta Pathway ⁶⁵ TCR Signaling ⁶⁵	12.77	ATM BRCA1 BRCA2 TP53
7	Pathways in cancer ³⁸	12.73	BRCA2 CCND1 ESR1 PTEN TP53
8	Endometrial cancer ³⁸ Show member pathways Acute myeloid leukemia ³⁸ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁷ Chronic myeloid leukemia ³⁸ Colorectal cancer ³⁸ Pancreatic cancer ³⁸ Prostate cancer ³⁸ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁸	12.72	BRCA2 CCND1 PTEN TP53
9	Deubiquitination ⁶⁷ Show member pathways Ub-specific processing proteases ⁶⁷	12.69	BRCA1 ESR1 PTEN TP53
10	Chks in Checkpoint Regulation ⁶⁵ Show member pathways DNA Repair Mechanisms ⁶⁵ Estrogen-mediated S-Phase Entry ⁶⁵ G2-M Phase Transition ⁶⁵ Parkinson's Disease Pathway ⁶⁵ SREBP Proteolysis ⁶⁵	12.52	ATM BRCA1 BRCA2 CCND1 ESR1 TP53
11	MicroRNAs in cancer ³⁸	12.4	ATM BRCA1 CCND1 PTEN TP53
12	DNA Damage ⁴	12.38	ATM BRCA1 BRCA2 CCND1 TP53
13	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.3	ATM BRCA1 BRCA2 CCND1 ESR1 PTEN
14	Development IGF-1 receptor signaling ²³ Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²³ Signal transduction AKT signaling ²³	12.27	CCND1 PTEN TP53
15	Cell cycle ³⁸ ¹	12.24	ATM CCND1 TP53
16	DNA Double Strand Break Response ⁶⁷ Show member pathways Nonhomologous End-Joining (NHEJ) ⁶⁷ Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ⁶⁷ Sensing of DNA Double Strand Breaks ⁶⁷	12.24	ATM BRCA1 TP53
17	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁸	12.24	ATM BRCA1 CCND1 PTEN TP53
18	Human T-cell leukemia virus 1 infection ³⁸	12.23	ATM CCND1 TP53
19	Cyclins and Cell Cycle Regulation ⁶⁵ Show member pathways Cell Cycle Control by BTG Proteins ⁶⁵ Cyclin D associated events in G1 ⁶⁷ G1 Phase ⁶⁷ G1-S Phase Transition ⁶⁵ Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes ⁶⁷	12.23	ATM CCND1 TP53
20	Proteoglycans in cancer ³⁸	12.17	CCND1 ESR1 TP53
21	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	12.17	BRCA1 BRCA2 CCND1 ESR1 PGR PTEN
22	Homologous DNA Pairing and Strand Exchange ⁶⁷ Show member pathways ATR Signaling ¹ HDR through Homologous Recombination (HRR) ⁶⁷ HDR through Single Strand Annealing (SSA) ⁶⁷ Presynaptic phase of homologous DNA pairing and strand exchange ⁶⁷	12.16	ATM BRCA1 BRCA2
23	Cell cycle Role of SCF complex in cell cycle regulation ²³ Show member pathways Cell cycle ESR1 regulation of G1/S transition ²³ Cell cycle Regulation of G1/S transition (part 1) ²³ Immune response MIF-JAB1 signaling ²³	12.14	BRCA1 CCND1 ESR1 PGR
24	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁶ Show member pathways Akt Signaling Pathway ⁶⁶	12.08	CCND1 PTEN TP53
25	p53 Signaling ⁶⁵ Show member pathways p53 Pathway ⁶⁸	12.08	ATM BRCA1 CCND1 PTEN TP53
26	Cellular senescence (KEGG) ³⁸	12.07	ATM CCND1 PTEN TP53
27	AKT Signaling Pathway ⁶⁸	12.02	CCND1 PTEN TP53
28	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) ⁶⁷ Show member pathways Homologous recombination ³⁸ Homologous recombination ¹ Resolution of D-Loop Structures ⁶⁷ Resolution of D-loop Structures through Holliday Junction Intermediates ⁶⁷	12.02	ATM BRCA1 BRCA2
29	FoxO signaling pathway ³⁸ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.98	ATM CCND1 PTEN
30	DNA Damage Response (only ATM dependent) ¹	11.91	ATM CCND1 PTEN TP53
31	Thyroid hormone signaling pathway ³⁸	11.9	CCND1 ESR1 TP53
32	Glioblastoma Multiforme ⁶⁵	11.88	CCND1 PTEN TP53
33	Small cell lung cancer ³⁸	11.8	CCND1 PTEN TP53
34	Androgen receptor signaling pathway ¹	11.78	BRCA1 CCND1 PTEN
35	ATM Pathway ⁶⁵ Show member pathways ATM Signaling Pathway ¹	11.76	ATM BRCA1 TP53
36	BRCA1 Pathway ⁶⁵ Show member pathways Fanconi's Anaemia Pathway ⁶⁵	11.71	ATM BRCA1 BRCA2 TP53
37	Platinum drug resistance ³⁸	11.68	ATM BRCA1 TP53
38	Regulation of Telomerase ¹	11.62	ATM CCND1 ESR1
39	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.58	ATM BRCA1 PTEN TP53
40	Copper homeostasis ¹	11.53	CCND1 PTEN TP53
41	Hepatitis C and Hepatocellular Carcinoma ¹	11.5	BRCA1 CCND1 TP53
42	DNA damage_Role of Brca1 and Brca2 in DNA repair ²³	11.5	ATM BRCA1 BRCA2 TP53
43	miRNAs involved in DNA damage response ¹	11.49	ATM CCND1 TP53
44	Integrated Breast Cancer Pathway ¹	11.35	ATM BRCA1 BRCA2 CCND1 ESR1 PTEN
45	FOXM1 transcription factor network ¹	11.33	BRCA2 CCND1 ESR1
46	Integrated Cancer Pathway ¹	11.33	ATM BRCA1 PTEN TP53
47	Ovarian tumor domain proteases ⁶⁷	11.32	ESR1 PTEN TP53
48	DNA damage_ATM/ATR regulation of G1/S checkpoint ²³	11.27	ATM BRCA1 CCND1 TP53
49	Signaling mediated by p38-alpha and p38-beta ¹	11.26	ESR1 TP53
50	Ovarian Infertility Genes ¹	11.21	ATM PGR

Sources

GO Terms for Synchronous Bilateral Breast Carcinoma

Cellular components related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein-containing complex	GO:0032991	9.46	BRCA1 BRCA2 ESR1 TP53
2	nucleoplasm	GO:0005654	9.23	ATM BRCA1 BRCA2 CCND1 ESR1 PGR
3	lateral element	GO:0000800	8.96	BRCA1 BRCA2

Biological processes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 27)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.97	ATM BRCA1 ESR1 PGR TP53
2	apoptotic process	GO:0006915	9.93	ATM BRCA1 PTEN TP53
3	positive regulation of transcription, DNA-templated	GO:0045893	9.89	BRCA1 BRCA2 ESR1 TP53
4	positive regulation of gene expression	GO:0010628	9.81	ATM BRCA1 PTEN TP53
5	cell cycle	GO:0007049	9.77	ATM BRCA1 BRCA2 CCND1 TP53
6	transcription initiation from RNA polymerase II promoter	GO:0006367	9.76	CCND1 ESR1 PGR
7	regulation of apoptotic process	GO:0042981	9.76	ATM BRCA1 ESR1 TP53
8	regulation of cell cycle	GO:0051726	9.72	ATM CCND1 PTEN
9	protein deubiquitination	GO:0016579	9.71	BRCA1 ESR1 PTEN TP53
10	response to gamma radiation	GO:0010332	9.62	BRCA2 TP53
11	cell aging	GO:0007569	9.62	BRCA2 TP53
12	cellular response to gamma radiation	GO:0071480	9.61	ATM TP53
13	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO:0042771	9.61	BRCA2 TP53
14	response to estrogen	GO:0043627	9.61	BRCA1 CCND1 ESR1
15	positive regulation of cell cycle arrest	GO:0071158	9.6	BRCA1 TP53
16	response to X-ray	GO:0010165	9.58	BRCA2 CCND1
17	mammary gland alveolus development	GO:0060749	9.56	CCND1 ESR1
18	cellular response to DNA damage stimulus	GO:0006974	9.55	ATM BRCA1 BRCA2 CCND1 TP53
19	DNA double-strand break processing	GO:0000729	9.54	ATM BRCA1
20	replicative senescence	GO:0090399	9.52	ATM TP53
21	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.49	ESR1 TP53
22	mitotic G1 DNA damage checkpoint	GO:0031571	9.48	CCND1 TP53
23	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.43	ATM BRCA1 BRCA2
24	mammary gland development	GO:0030879	9.33	PGR
25	chordate embryonic development	GO:0043009	9.32	BRCA1 BRCA2
26	response to estradiol	GO:0032355	9.13	CCND1 ESR1 PTEN
27	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	8.8	BRCA1 BRCA2 TP53

Molecular functions related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA binding	GO:0003677	9.73	ATM BRCA1 BRCA2 ESR1 PGR TP53
2	protein kinase binding	GO:0019901	9.46	CCND1 ESR1 PTEN TP53
3	identical protein binding	GO:0042802	9.43	BRCA1 BRCA2 ESR1 PGR PTEN TP53
4	steroid binding	GO:0005496	9.32	ESR1 PGR
5	enzyme binding	GO:0019899	9.1	BRCA1 CCND1 ESR1 PGR PTEN TP53

Sources

Sources for Synchronous Bilateral Breast Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

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¹⁶ DrugBank

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¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia