MCID: SYN003
MIFTS: 33

Synchronous Bilateral Breast Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Synchronous Bilateral Breast Carcinoma

MalaCards integrated aliases for Synchronous Bilateral Breast Carcinoma:

Name: Synchronous Bilateral Breast Carcinoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6742
NCIt 50 C40370
UMLS 71 C1515107

Summaries for Synchronous Bilateral Breast Carcinoma

MalaCards based summary : Synchronous Bilateral Breast Carcinoma is related to bilateral breast cancer and cowden syndrome. An important gene associated with Synchronous Bilateral Breast Carcinoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are ERK Signaling and Gene Expression. Affiliated tissues include breast, and related phenotypes are Decreased viability after ionizing radiation and cellular

Related Diseases for Synchronous Bilateral Breast Carcinoma

Diseases related to Synchronous Bilateral Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 410)
# Related Disease Score Top Affiliating Genes
1 bilateral breast cancer 30.1 PTEN PGR ESR1 ERBB2 BRCA2 BRCA1
2 cowden syndrome 29.1 TP53 PTEN ERBB2 EGFR BRCA2 BRCA1
3 ductal carcinoma in situ 28.0 TP53 PTEN PGR KRT5 KRT14 ESR1
4 breast ductal carcinoma 27.8 TP53 PGR KRT5 KRT14 ESR1 ERBB2
5 in situ carcinoma 27.7 TP53 PTEN PGR KRT5 KRT17 KRT14
6 fallopian tube clear cell adenocarcinoma 10.4 BRCA2 BRCA1
7 cancerophobia 10.4 BRCA2 BRCA1
8 ovary transitional cell carcinoma 10.4 BRCA2 BRCA1
9 bartholin's gland adenoid cystic carcinoma 10.4 PGR ESR1
10 uterine corpus adenosarcoma 10.4 PGR ESR1
11 chronic tympanitis 10.4 PGR ESR1
12 granulomatous endometritis 10.4 PGR ESR1
13 vulvar syringoma 10.4 PGR ESR1
14 nosophobia 10.4 BRCA2 BRCA1
15 hereditary site-specific ovarian cancer syndrome 10.4 BRCA2 BRCA1
16 tetraploidy 10.4 BRCA2 BRCA1
17 b-lymphoblastic leukemia/lymphoma with hyperdiploidy 10.4 BRCA2 BRCA1
18 lung leiomyoma 10.4 PGR ESR1
19 adult type testicular granulosa cell tumor 10.4 PGR ESR1
20 scirrhous adenocarcinoma 10.3 PGR ERBB2
21 intravenous leiomyomatosis 10.3 PGR ESR1
22 endosalpingiosis 10.3 PGR BRCA2 BRCA1
23 intracranial meningioma 10.3 PGR ESR1
24 breast duct papilloma 10.3 PTEN PGR
25 luminal breast carcinoma b 10.3 PGR ERBB2
26 bile duct cystadenoma 10.3 ESR1 ATM
27 familial ovarian cancer 10.3 ESR1 BRCA2 BRCA1
28 gastric papillary adenocarcinoma 10.3 TP53 ERBB2
29 esophageal leukoplakia 10.3 TP53 CCND1
30 vulvar leiomyoma 10.3 PGR ESR1
31 bartholin's gland adenoma 10.3 TP53 PGR ESR1
32 bartholin's gland benign neoplasm 10.3 TP53 PGR ESR1
33 vestibular gland benign neoplasm 10.3 TP53 PGR ESR1
34 basosquamous carcinoma 10.3 TP53 KRT17
35 ovarian seromucinous carcinoma 10.3 TP53 PGR ESR1
36 bizarre leiomyoma 10.3 TP53 PGR ESR1
37 breast-ovarian cancer, familial 2 10.3 BRCA2 BRCA1
38 fallopian tube disease 10.3 TP53 BRCA2 BRCA1
39 cervical adenosarcoma 10.3 TP53 PGR ESR1
40 vaginal cancer 10.3 TP53 PGR ESR1
41 pancreatic foamy gland adenocarcinoma 10.3 TP53 CCND1
42 maxillary sinus adenocarcinoma 10.3 TP53 ATM
43 parotid gland cancer 10.3 TP53 ERBB2
44 myasthenic syndrome, congenital, 6, presynaptic 10.3 TP53 BRCA2 BRCA1
45 dysplastic nevus syndrome 10.3 BRCA2 BRCA1 ATM
46 gastric diffuse adenocarcinoma 10.3 PGR ERBB2
47 papillary carcinoma 10.3 PGR ESR1 ERBB2
48 peritoneal serous adenocarcinoma 10.2 TP53 PGR KRT17
49 glassy cell carcinoma of the cervix 10.2 PGR ESR1 ERBB2
50 breast intraductal papillomatosis 10.2 PGR ESR1 ERBB2

Graphical network of the top 20 diseases related to Synchronous Bilateral Breast Carcinoma:



Diseases related to Synchronous Bilateral Breast Carcinoma

Symptoms & Phenotypes for Synchronous Bilateral Breast Carcinoma

GenomeRNAi Phenotypes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability after ionizing radiation GR00232-A-2 8.8 ATM BRCA1 BRCA2

MGI Mouse Phenotypes related to Synchronous Bilateral Breast Carcinoma:

46 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.44 ATM BABAM2 BRCA1 BRCA2 CCND1 EGFR
2 endocrine/exocrine gland MP:0005379 10.4 ATM BRCA1 BRCA2 CCND1 CDH3 EGFR
3 digestive/alimentary MP:0005381 10.39 BRCA1 BRCA2 CCND1 EGFR ERBB2 ESR1
4 growth/size/body region MP:0005378 10.39 ATM BRCA1 BRCA2 CCND1 EGFR ERBB2
5 behavior/neurological MP:0005386 10.38 ATM BABAM2 BRCA1 BRCA2 CCND1 ERBB2
6 homeostasis/metabolism MP:0005376 10.37 ATM BABAM2 BRCA1 BRCA2 CCND1 EGFR
7 integument MP:0010771 10.37 ATM BRCA1 BRCA2 CCND1 CDH3 EGFR
8 mortality/aging MP:0010768 10.33 ATM BRCA1 BRCA2 CCND1 EGFR ERBB2
9 hematopoietic system MP:0005397 10.31 ATM BRCA1 BRCA2 CCND1 EGFR ESR1
10 cardiovascular system MP:0005385 10.3 ATM BRCA1 CCND1 EGFR ERBB2 ESR1
11 immune system MP:0005387 10.29 ATM BRCA1 BRCA2 CCND1 EGFR ESR1
12 embryo MP:0005380 10.27 ATM BRCA1 BRCA2 EGFR ERBB2 ESR1
13 craniofacial MP:0005382 10.24 CCND1 EGFR ERBB2 KIT KRT14 KRT17
14 limbs/digits/tail MP:0005371 10.18 BRCA1 BRCA2 EGFR ERBB2 ESR1 KIT
15 neoplasm MP:0002006 10.18 ATM BRCA1 BRCA2 CCND1 EGFR ERBB2
16 adipose tissue MP:0005375 10.16 ATM BRCA1 EGFR ESR1 KRT14 PTEN
17 nervous system MP:0003631 10.11 ATM BRCA1 BRCA2 CCND1 EGFR ERBB2
18 muscle MP:0005369 10.03 BRCA1 EGFR ERBB2 ESR1 KIT PGR
19 normal MP:0002873 10.02 BRCA1 BRCA2 CCND1 EGFR ERBB2 ESR1
20 reproductive system MP:0005389 9.97 ATM BABAM2 BRCA1 BRCA2 CCND1 EGFR
21 pigmentation MP:0001186 9.8 BRCA1 EGFR KIT KRT14 KRT17 PTEN
22 respiratory system MP:0005388 9.65 BRCA1 CCND1 EGFR ERBB2 ESR1 KIT
23 skeleton MP:0005390 9.36 BABAM2 BRCA1 BRCA2 CCND1 EGFR ERBB2

Drugs & Therapeutics for Synchronous Bilateral Breast Carcinoma

Search Clinical Trials , NIH Clinical Center for Synchronous Bilateral Breast Carcinoma

Genetic Tests for Synchronous Bilateral Breast Carcinoma

Anatomical Context for Synchronous Bilateral Breast Carcinoma

MalaCards organs/tissues related to Synchronous Bilateral Breast Carcinoma:

40
Breast

Publications for Synchronous Bilateral Breast Carcinoma

Articles related to Synchronous Bilateral Breast Carcinoma:

(show all 14)
# Title Authors PMID Year
1
Radiation therapy of synchronous bilateral breast carcinoma (SBBC) using multiple techniques. 61
28988893 2018
2
EVOLUTION OF SYNCHRONOUS BILATERAL BREAST CARCINOMA IN A YOUNG PATIENT. 61
27125095 2016
3
Periductal stromal tumor of the breast with synchronous bilateral breast cancer. 61
24982380 2014
4
Synchronous bilateral breast carcinoma and axillary non-hodgkin lymphoma: a case report and review of the literature. 61
23050177 2012
5
Synchronous bilateral breast carcinoma with two different morphology subtypes: a case report. 61
20698158 2010
6
Synchronous bilateral breast carcinoma in a patient with cowden syndrome: a case report with morphologic, immunohistochemical and genetic analysis. 61
19968660 2010
7
Diagnostic and prognostic utility of molecular markers in synchronous bilateral breast carcinoma. 61
18469799 2008
8
Clinicopathological characteristics of synchronous bilateral breast carcinomas. Report of 30 patients. 61
18444533 2008
9
[Synchronous bilateral breast cancer: risk factors, diagnosis, histology and treatment]. 61
18178120 2008
10
Synchronous bilateral breast carcinoma in a 50-year-old man with 45,X/46,XY mosaic karyotype: report of a case. 61
16378198 2006
11
Molecular study of clonality in multifocal and bilateral breast tumors. 61
15648612 2004
12
Histological grade, p53, HER2 and hormone receptor status of synchronous bilateral breast carcinoma. 61
12016392 2002
13
Bilateral breast carcinoma: risk factors and outcomes for patients with synchronous and metachronous disease. 61
10870056 2000
14
Breast-conserving therapy for stage I-II synchronous bilateral breast carcinoma. 61
9083159 1997

Variations for Synchronous Bilateral Breast Carcinoma

Expression for Synchronous Bilateral Breast Carcinoma

Search GEO for disease gene expression data for Synchronous Bilateral Breast Carcinoma.

Pathways for Synchronous Bilateral Breast Carcinoma

Pathways related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 TP53 PTEN KIT ESR1 ERBB2 EGFR
2
Show member pathways
13.79 TP53 PTEN PGR NFIB KIT ESR1
3
Show member pathways
13.69 TP53 KIT ESR1 ERBB2 EGFR CCND1
4
Show member pathways
12.87 TP53 PTEN KIT ERBB2 EGFR CCND1
5
Show member pathways
12.84 TP53 PTEN KIT ERBB2 EGFR CCND1
6
Show member pathways
12.83 TP53 PTEN ESR1 BRCA1 BABAM2
7
Show member pathways
12.74 TP53 PTEN KIT ERBB2 EGFR
8 12.7 TP53 PTEN KIT ESR1 ERBB2 EGFR
9
Show member pathways
12.68 PGR KRT17 KRT14 ESR1 EGFR
10
Show member pathways
12.63 TP53 PTEN ERBB2 EGFR CCND1
11
Show member pathways
12.63 TP53 ESR1 CCND1 BRCA2 BRCA1 BABAM2
12
Show member pathways
12.49 TP53 PTEN ERBB2 EGFR
13
Show member pathways
12.48 PTEN ESR1 ERBB2 CCND1
14 12.48 TP53 CCND1 BRCA2 BRCA1 BABAM2 ATM
15
Show member pathways
12.44 TP53 ERBB2 EGFR ATM
16
Show member pathways
12.41 TP53 PTEN ESR1 ERBB2 EGFR CCND1
17
Show member pathways
12.39 TP53 PTEN CCND1 BRCA1 ATM
18
Show member pathways
12.37 TP53 BRCA1 BABAM2 ATM
19 12.36 TP53 PTEN ERBB2 EGFR CCND1 BRCA1
20 12.35 TP53 PTEN CCND1 ATM
21
Show member pathways
12.33 ESR1 ERBB2 EGFR CCND1
22
Show member pathways
12.32 TP53 PTEN ERBB2 EGFR CCND1
23
Show member pathways
12.32 TP53 PTEN PGR KIT ESR1 ERBB2
24 12.3 TP53 ESR1 ERBB2 EGFR CCND1
25
Show member pathways
12.24 TP53 PTEN ERBB2 EGFR CCND1
26
Show member pathways
12.23 PGR ESR1 CCND1 BRCA1
27
Show member pathways
12.23 TP53 PTEN CCND1 BRCA1 ATM
28 12.17 TP53 PTEN CCND1 ATM
29
Show member pathways
12.15 BRCA2 BRCA1 BABAM2 ATM
30
Show member pathways
12.1 PTEN EGFR CCND1 ATM
31 11.99 TP53 PTEN EGFR CCND1
32
Show member pathways
11.98 PGR ESR1 ERBB2 EGFR
33 11.95 TP53 PTEN ERBB2 CCND1 ATM
34
Show member pathways
11.9 KIT ESR1 ERBB2 EGFR
35 11.89 PTEN EGFR CCND1 BRCA1
36 11.86 TP53 PTEN CCND1
37
Show member pathways
11.84 TP53 BRCA1 ATM
38
Show member pathways
11.83 TP53 BRCA2 BRCA1 ATM
39 11.82 TP53 KRT5 KRT17 KRT14
40 11.75 TP53 ERBB2 BRCA1 ATM
41 11.74 TP53 ERBB2 EGFR CCND1
42
Show member pathways
11.73 ESR1 EGFR CCND1
43 11.68 ESR1 EGFR CCND1 ATM
44 11.66 ERBB2 CCND1 BRCA1
45 11.65 TP53 PTEN KIT ERBB2 EGFR
46 11.61 TP53 PTEN CCND1
47 11.58 TP53 EGFR CCND1
48 11.58 TP53 CCND1 BRCA1
49 11.57 TP53 CCND1 ATM
50 11.55 TP53 PTEN NFIB ERBB2 BRCA1 ATM

GO Terms for Synchronous Bilateral Breast Carcinoma

Cellular components related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.96 TP53 PTEN PGR NFIB ESR1 CCND1
2 nucleus GO:0005634 9.8 TP53 PTEN PGR NFIB KRT5 KRT14
3 cytoplasm GO:0005737 9.53 TP53 PTEN PGR KRT5 KRT17 KRT14
4 BRCA1-A complex GO:0070531 9.16 BRCA1 BABAM2

Biological processes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 10.15 TP53 PGR NFIB KIT ESR1 ERBB2
2 protein phosphorylation GO:0006468 10.08 KIT ERBB2 EGFR CCND1 ATM
3 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 TP53 PGR NFIB ESR1 EGFR BRCA1
4 positive regulation of cell proliferation GO:0008284 10.04 PTEN KIT ERBB2 EGFR CCND1
5 positive regulation of transcription, DNA-templated GO:0045893 10.03 TP53 NFIB ESR1 EGFR BRCA2 BRCA1
6 response to drug GO:0042493 9.99 TP53 PTEN CDH3 CCND1
7 cell cycle GO:0007049 9.97 TP53 CCND1 BRCA2 BRCA1 BABAM2 ATM
8 regulation of apoptotic process GO:0042981 9.96 TP53 ESR1 BRCA1 ATM
9 heart development GO:0007507 9.94 TP53 PTEN ERBB2 ATM
10 keratinization GO:0031424 9.91 KRT5 KRT17 KRT14 CDH3
11 positive regulation of protein kinase B signaling GO:0051897 9.89 KIT ESR1 ERBB2 EGFR
12 protein autophosphorylation GO:0046777 9.88 KIT ERBB2 EGFR ATM
13 wound healing GO:0042060 9.87 ERBB2 EGFR CDH3
14 transcription initiation from RNA polymerase II promoter GO:0006367 9.87 PTEN PGR ESR1 CCND1
15 cellular response to DNA damage stimulus GO:0006974 9.85 TP53 CCND1 BRCA2 BRCA1 BABAM2 ATM
16 positive regulation of cell growth GO:0030307 9.83 KRT17 ERBB2 EGFR
17 double-strand break repair via homologous recombination GO:0000724 9.82 BRCA2 BRCA1 ATM
18 regulation of cell cycle GO:0051726 9.81 TP53 PTEN CCND1 ATM
19 positive regulation of kinase activity GO:0033674 9.8 KIT ERBB2 EGFR
20 double-strand break repair via nonhomologous end joining GO:0006303 9.8 BRCA1 BABAM2 ATM
21 protein deubiquitination GO:0016579 9.8 TP53 PTEN ESR1 BRCA1 BABAM2
22 response to estrogen GO:0043627 9.79 ESR1 CCND1 BRCA1
23 positive regulation of MAP kinase activity GO:0043406 9.79 KIT ERBB2 EGFR
24 response to estradiol GO:0032355 9.73 PTEN ESR1 EGFR CCND1
25 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.7 BRCA2 BRCA1 ATM
26 positive regulation of phospholipase C activity GO:0010863 9.68 KIT ESR1
27 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.68 TP53 EGFR
28 hemidesmosome assembly GO:0031581 9.68 KRT5 KRT14
29 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.67 TP53 ESR1
30 signal transduction involved in G2 DNA damage checkpoint GO:0072425 9.67 BRCA1 BABAM2
31 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.67 TP53 ESR1
32 tongue development GO:0043586 9.66 KIT EGFR
33 intracellular steroid hormone receptor signaling pathway GO:0030518 9.66 PGR ESR1
34 mitotic G1 DNA damage checkpoint GO:0031571 9.63 TP53 CCND1
35 positive regulation of DNA repair GO:0045739 9.63 EGFR BRCA1 BABAM2
36 negative regulation of ERBB signaling pathway GO:1901185 9.6 ERBB2 EGFR
37 chordate embryonic development GO:0043009 9.58 BRCA2 BRCA1
38 response to X-ray GO:0010165 9.5 TP53 CCND1 BRCA2
39 response to UV-A GO:0070141 9.48 EGFR CCND1
40 double-strand break repair GO:0006302 9.46 TP53 BRCA2 BRCA1 BABAM2
41 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.43 TP53 BRCA2 BRCA1
42 response to ionizing radiation GO:0010212 9.26 KRT14 BRCA1 BABAM2 ATM
43 positive regulation of gene expression GO:0010628 9.17 TP53 PTEN KIT ERBB2 CDH3 BRCA1

Molecular functions related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.77 KIT ERBB2 EGFR CCND1 ATM
2 protein kinase binding GO:0019901 9.65 TP53 PTEN ESR1 EGFR CCND1
3 protease binding GO:0002020 9.63 TP53 KIT BRCA2
4 protein phosphatase binding GO:0019903 9.61 TP53 ERBB2 EGFR
5 identical protein binding GO:0042802 9.61 TP53 PTEN PGR ESR1 ERBB2 EGFR
6 ATPase binding GO:0051117 9.58 PGR ESR1 EGFR
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 KIT ERBB2 EGFR
8 nitric-oxide synthase regulator activity GO:0030235 9.32 ESR1 EGFR
9 enzyme binding GO:0019899 9.17 TP53 PTEN PGR ESR1 EGFR CCND1

Sources for Synchronous Bilateral Breast Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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