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MCID: SYN003
MIFTS: 37

Synchronous Bilateral Breast Carcinoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Synchronous Bilateral Breast Carcinoma

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MalaCards integrated aliases for Synchronous Bilateral Breast Carcinoma:

Name: Synchronous Bilateral Breast Carcinoma 12 15 73

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6742
NCIt 50 C40370
UMLS 73 C1515107
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Summaries for Synchronous Bilateral Breast Carcinoma

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MalaCards based summary : Synchronous Bilateral Breast Carcinoma is related to cowden disease and bilateral breast cancer. An important gene associated with Synchronous Bilateral Breast Carcinoma is ATM (ATM Serine/Threonine Kinase), and among its related pathways/superpathways are Gene Expression and Cell Cycle, Mitotic. The drugs Exemestane and Letrozole have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and colon, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

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Related Diseases for Synchronous Bilateral Breast Carcinoma

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Diseases related to Synchronous Bilateral Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 cowden disease 29.9 BRCA1 BRCA2 PTEN
2 bilateral breast cancer 29.7 ATM BRCA1 BRCA2 PGR
3 lymphoma, non-hodgkin, familial 29.4 ATM CCND1 TP53
4 breast cancer 28.4 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
5 breast duct papilloma 10.2 PGR PTEN
6 clivus chordoma 10.2 ATM PTEN
7 hereditary site-specific ovarian cancer syndrome 10.2 BRCA1 BRCA2
8 corneal abscess 10.2 PGR PTEN
9 breast reconstruction 10.2 BRCA1 BRCA2
10 tuberculous salpingitis 10.2 BRCA1 BRCA2
11 breast-ovarian cancer, familial 1 10.1 BRCA1 BRCA2
12 fallopian tube adenocarcinoma 10.1 BRCA1 BRCA2
13 vestibular gland benign neoplasm 10.1 ESR1 PGR
14 bartholin's gland adenoma 10.1 ESR1 PGR
15 vulvar syringoma 10.1 ESR1 PGR
16 glassy cell carcinoma of the cervix 10.1 ESR1 PGR
17 lung leiomyoma 10.1 ESR1 PGR
18 vulvar benign neoplasm 10.1 ESR1 PGR
19 trigonitis 10.1 ESR1 PGR
20 vulvar leiomyoma 10.1 ESR1 PGR
21 predominantly cortical thymoma 10.1 ESR1 PGR
22 breast scirrhous carcinoma 10.1 ESR1 PGR
23 bartholin's gland benign neoplasm 10.1 ESR1 PGR
24 breast giant fibroadenoma 10.1 BRCA2 ESR1
25 oncocytic breast carcinoma 10.1 ESR1 PGR
26 premature menopause 10.1 BRCA1 BRCA2
27 progesterone-receptor positive breast cancer 10.1 ESR1 PGR
28 peritoneum cancer 10.1 BRCA1 BRCA2
29 progesterone resistance 10.1 ESR1 PGR
30 cribriform carcinoma 10.1 ESR1 PGR
31 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
32 adenoid basal cell carcinoma 10.1 ESR1 PGR
33 breast adenoid cystic carcinoma 10.1 ESR1 PGR
34 apocrine adenocarcinoma 10.1 ESR1 PGR
35 peritoneal benign neoplasm 10.1 ESR1 PGR
36 fallopian tube disease 10.1 BRCA1 BRCA2
37 gender identity disorder 10.1 ESR1 PGR
38 deep angioma 10.1 ESR1 PGR
39 diffuse peritoneal leiomyomatosis 10.1 ESR1 PGR
40 estrogen excess 10.1 ESR1 PGR
41 intramuscular hemangioma 10.1 ESR1 PGR
42 mammographic density 10.1 ESR1 PGR
43 cervical clear cell adenocarcinoma 10.1 ESR1 PGR
44 retinitis pigmentosa 47 10.1 ESR1 PGR
45 inflammatory breast carcinoma 10.1 ESR1 PGR
46 endometrium carcinoma in situ 10.1 PGR TP53
47 retinitis pigmentosa 20 10.1 ESR1 PGR
48 luminal breast carcinoma 10.1 ESR1 PGR
49 endometriosis of ovary 10.1 ESR1 PGR
50 breast malignant phyllodes tumor 10.1 PGR TP53

Graphical network of the top 20 diseases related to Synchronous Bilateral Breast Carcinoma:



Diseases related to Synchronous Bilateral Breast Carcinoma
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Symptoms & Phenotypes for Synchronous Bilateral Breast Carcinoma

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GenomeRNAi Phenotypes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.2 BRCA1
2 Decreased homologous recombination repair frequency GR00151-A-2 10.2 BRCA1
3 Decreased homologous recombination repair frequency GR00236-A-1 10.2 BRCA1 BRCA2 PGR
4 Decreased homologous recombination repair frequency GR00236-A-2 10.2 ATM BRCA1 BRCA2 PGR
5 Decreased homologous recombination repair frequency GR00236-A-3 10.2 BRCA1 BRCA2
6 Decreased viability in esophageal squamous lineage GR00235-A 9.97 BRCA1 BRCA2 CCND1 ESR1 PGR PTEN
7 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 ATM BRCA1 BRCA2 PTEN TP53
8 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 ATM BRCA1 BRCA2 PTEN TP53 CCND1
9 Increased cell death HMECs cells GR00103-A-0 9.62 BRCA1 PGR PTEN TP53
10 Decreased viability after ionizing radiation GR00232-A-2 9.58 ATM BRCA1 BRCA2
11 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.46 ATM BRCA1 BRCA2 TP53
12 Decreased TP53 mRNA expression GR00389-S-5 9.43 ATM TP53
13 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.43 CCND1 ESR1 PTEN
14 Synthetic lethal with cisplatin GR00101-A-1 8.96 BRCA1 BRCA2

MGI Mouse Phenotypes related to Synchronous Bilateral Breast Carcinoma:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.24 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
2 endocrine/exocrine gland MP:0005379 10.2 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
3 cardiovascular system MP:0005385 10.19 ATM BRCA1 CCND1 ESR1 PGR PTEN
4 cellular MP:0005384 10.18 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
5 hematopoietic system MP:0005397 10.18 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
6 homeostasis/metabolism MP:0005376 10.16 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
7 immune system MP:0005387 10.15 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
8 integument MP:0010771 10.13 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
9 digestive/alimentary MP:0005381 10.11 BRCA1 BRCA2 CCND1 ESR1 PTEN SLC5A7
10 embryo MP:0005380 10.1 ATM BRCA1 BRCA2 ESR1 PGR PTEN
11 mortality/aging MP:0010768 10.09 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
12 growth/size/body region MP:0005378 10.08 ATM BRCA1 BRCA2 CCND1 ESR1 PTEN
13 adipose tissue MP:0005375 10 ATM BRCA1 ESR1 PTEN TP53
14 neoplasm MP:0002006 9.97 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
15 limbs/digits/tail MP:0005371 9.93 BRCA1 BRCA2 ESR1 PGR PTEN TP53
16 nervous system MP:0003631 9.92 ATM BRCA1 BRCA2 CCND1 ESR1 PTEN
17 normal MP:0002873 9.86 BRCA1 BRCA2 CCND1 ESR1 PGR PTEN
18 muscle MP:0005369 9.8 BRCA1 ESR1 PGR PTEN TP53
19 reproductive system MP:0005389 9.76 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
20 respiratory system MP:0005388 9.43 BRCA1 CCND1 ESR1 PTEN SLC5A7 TP53
21 skeleton MP:0005390 9.17 BRCA1 BRCA2 CCND1 ESR1 PGR PTEN
Sources

Drugs & Therapeutics for Synchronous Bilateral Breast Carcinoma

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Drugs for Synchronous Bilateral Breast Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
2
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
3
Tamoxifen Approved Phase 3 10540-29-1 2733526
4
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
5
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
6 Bone Density Conservation Agents Phase 3
7 Estrogen Antagonists Phase 3
8 Antineoplastic Agents, Hormonal Phase 3
9 Citrate Phase 3
10 Hormones Phase 3
11 Calcium, Dietary Phase 3
12 Estrogen Receptor Modulators Phase 3
13 Estrogens Phase 3
14 Selective Estrogen Receptor Modulators Phase 3
15 Steroid Synthesis Inhibitors Phase 3
16 Estrogen Receptor Antagonists Phase 3
17 Anticoagulants Phase 3
18 Hormone Antagonists Phase 3
19 Chelating Agents Phase 3
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
21 Aromatase Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Active, not recruiting NCT01272037 Phase 3 Anastrozole;Exemestane;Letrozole;Systemic Chemotherapy;Tamoxifen Citrate

Search NIH Clinical Center for Synchronous Bilateral Breast Carcinoma

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Genetic Tests for Synchronous Bilateral Breast Carcinoma

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Anatomical Context for Synchronous Bilateral Breast Carcinoma

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MalaCards organs/tissues related to Synchronous Bilateral Breast Carcinoma:

41
Brain, Bone, Colon, Ovary, Prostate, Cervix, Smooth Muscle
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Publications for Synchronous Bilateral Breast Carcinoma

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Articles related to Synchronous Bilateral Breast Carcinoma:

# Title Authors Year
1
Radiation therapy of synchronous bilateral breast carcinoma (SBBC) using multiple techniques. ( 28988893 )
2018
2
EVOLUTION OF SYNCHRONOUS BILATERAL BREAST CARCINOMA IN A YOUNG PATIENT. ( 27125095 )
2016
3
Synchronous bilateral breast carcinoma and axillary non-hodgkin lymphoma: a case report and review of the literature. ( 23050177 )
2012
4
Synchronous bilateral breast carcinoma in a patient with cowden syndrome: a case report with morphologic, immunohistochemical and genetic analysis. ( 19968660 )
2010
5
Synchronous bilateral breast carcinoma with two different morphology subtypes: a case report. ( 20698158 )
2010
6
Diagnostic and prognostic utility of molecular markers in synchronous bilateral breast carcinoma. ( 18469799 )
2008
7
Synchronous bilateral breast carcinoma in a 50-year-old man with 45,X/46,XY mosaic karyotype: report of a case. ( 16378198 )
2006
8
Histological grade, p53, HER2 and hormone receptor status of synchronous bilateral breast carcinoma. ( 12016392 )
2002
9
Breast-conserving therapy for stage I-II synchronous bilateral breast carcinoma. ( 9083159 )
1997
Sources

Variations for Synchronous Bilateral Breast Carcinoma

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Expression for Synchronous Bilateral Breast Carcinoma

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Search GEO for disease gene expression data for Synchronous Bilateral Breast Carcinoma.
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Pathways for Synchronous Bilateral Breast Carcinoma

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Pathways related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Gene Expression 66
Show member pathways
 13.63 ATM BRCA1 ESR1 PGR PTEN TP53
2
Cell Cycle, Mitotic 66
Show member pathways
 13.27 ATM BRCA1 BRCA2 CCND1 TP53
3
Human cytomegalovirus infection 37
Show member pathways
 12.91 ATM CCND1 PTEN TP53
4
PI3K-Akt signaling pathway 37
Show member pathways
 12.87 ATM BRCA1 CCND1 PTEN TP53
5
Regulation of TP53 Activity 66
Show member pathways
 12.82 ATM BRCA1 PTEN TP53
6
TCR Signaling (Qiagen) 64
Show member pathways
 12.77 ATM BRCA1 BRCA2 TP53
7
Endometrial cancer 37
Show member pathways
 12.72 BRCA2 CCND1 PTEN TP53
8
Pathways in cancer 37
12.72 BRCA2 CCND1 ESR1 PTEN TP53
9
Deubiquitination 66
Show member pathways
 12.69 BRCA1 ESR1 PTEN TP53
10
Chks in Checkpoint Regulation 64
Show member pathways
 12.52 ATM BRCA1 BRCA2 CCND1 ESR1 TP53
11
MicroRNAs in cancer 37
12.4 ATM BRCA1 CCND1 PTEN TP53
12
DNA Damage 4
12.38 ATM BRCA1 BRCA2 CCND1 TP53
13
Glioma 37
Show member pathways
 12.37 ATM BRCA1 BRCA2 CCND1 ESR1 PTEN
14
Human T-cell leukemia virus 1 infection 37
12.3 ATM CCND1 TP53
15
Development IGF-1 receptor signaling 22
Show member pathways
 12.27 CCND1 PTEN TP53
16
Cell cycle 1 37
12.24 ATM CCND1 TP53
17
DNA Double Strand Break Response 66
Show member pathways
 12.24 ATM BRCA1 TP53
18
DNA Damage Response 1
Show member pathways
 12.24 ATM BRCA1 CCND1 PTEN TP53
19
Cyclins and Cell Cycle Regulation 64
Show member pathways
 12.23 ATM CCND1 TP53
20
Proteoglycans in cancer 37
12.17 CCND1 ESR1 TP53
21
Gastric cancer 37
Show member pathways
 12.17 BRCA1 BRCA2 CCND1 ESR1 PGR PTEN
22
Homologous DNA Pairing and Strand Exchange 66
Show member pathways
 12.16 ATM BRCA1 BRCA2
23
Cell cycle Role of SCF complex in cell cycle regulation 22
Show member pathways
 12.14 BRCA1 CCND1 ESR1 PGR
24
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 12.08 CCND1 PTEN TP53
25
p53 Signaling 64
Show member pathways
 12.08 ATM BRCA1 CCND1 PTEN TP53
26
Cellular senescence (KEGG) 37
12.07 ATM CCND1 PTEN TP53
27
AKT Signaling Pathway 67
12.02 CCND1 PTEN TP53
28
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 66
Show member pathways
 12.02 ATM BRCA1 BRCA2
29
FoxO signaling pathway 37
Show member pathways
 11.98 ATM CCND1 PTEN
30
DNA Damage Response (only ATM dependent) 1
11.91 ATM CCND1 PTEN TP53
31
Thyroid hormone signaling pathway 37
11.9 CCND1 ESR1 TP53
32
Glioblastoma Multiforme 64
11.88 CCND1 PTEN TP53
33
Small cell lung cancer 37
11.8 CCND1 PTEN TP53
34
Androgen receptor signaling pathway 1
11.78 BRCA1 CCND1 PTEN
35
ATM Pathway 64
Show member pathways
 11.76 ATM BRCA1 TP53
36
BRCA1 Pathway 64
Show member pathways
 11.71 ATM BRCA1 BRCA2 TP53
37
Platinum drug resistance 37
11.68 ATM BRCA1 TP53
38
Regulation of Telomerase 1
11.62 ATM CCND1 ESR1
39
Pathways Affected in Adenoid Cystic Carcinoma 1
11.58 ATM BRCA1 PTEN TP53
40
Copper homeostasis 1
11.53 CCND1 PTEN TP53
41
Hepatitis C and Hepatocellular Carcinoma 1
11.5 BRCA1 CCND1 TP53
42
DNA damage_Role of Brca1 and Brca2 in DNA repair 22
11.5 ATM BRCA1 BRCA2 TP53
43
miRNAs involved in DNA damage response 1
11.49 ATM CCND1 TP53
44
Integrated Breast Cancer Pathway 1
11.35 ATM BRCA1 BRCA2 CCND1 ESR1 PTEN
45
FOXM1 transcription factor network 1
11.33 BRCA2 CCND1 ESR1
46
Integrated Cancer Pathway 1
11.33 ATM BRCA1 PTEN TP53
47
Ovarian tumor domain proteases 66
11.32 ESR1 PTEN TP53
48
DNA damage_ATM/ATR regulation of G1/S checkpoint 22
11.27 ATM BRCA1 CCND1 TP53
49
Signaling mediated by p38-alpha and p38-beta 1
11.26 ESR1 TP53
50
Ovarian Infertility Genes 1
11.21 ATM PGR
Sources

GO Terms for Synchronous Bilateral Breast Carcinoma

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Cellular components related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.46 BRCA1 BRCA2 ESR1 TP53
2 nucleoplasm GO:0005654 9.23 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
3 lateral element GO:0000800 8.96 BRCA1 BRCA2

Biological processes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 ATM BRCA1 ESR1 PGR TP53
2 apoptotic process GO:0006915 9.93 ATM BRCA1 PTEN TP53
3 positive regulation of transcription, DNA-templated GO:0045893 9.89 BRCA1 BRCA2 ESR1 TP53
4 positive regulation of gene expression GO:0010628 9.81 ATM BRCA1 PTEN TP53
5 cell cycle GO:0007049 9.77 ATM BRCA1 BRCA2 CCND1 TP53
6 transcription initiation from RNA polymerase II promoter GO:0006367 9.76 CCND1 ESR1 PGR
7 regulation of apoptotic process GO:0042981 9.76 ATM BRCA1 ESR1 TP53
8 regulation of cell cycle GO:0051726 9.72 ATM CCND1 PTEN
9 protein deubiquitination GO:0016579 9.71 BRCA1 ESR1 PTEN TP53
10 mammary gland development GO:0030879 9.63 BRCA2 PGR
11 response to gamma radiation GO:0010332 9.62 BRCA2 TP53
12 cell aging GO:0007569 9.62 BRCA2 TP53
13 cellular response to gamma radiation GO:0071480 9.61 ATM TP53
14 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.61 BRCA2 TP53
15 response to estrogen GO:0043627 9.61 BRCA1 CCND1 ESR1
16 positive regulation of cell cycle arrest GO:0071158 9.6 BRCA1 TP53
17 response to X-ray GO:0010165 9.58 BRCA2 CCND1
18 mammary gland alveolus development GO:0060749 9.56 CCND1 ESR1
19 cellular response to DNA damage stimulus GO:0006974 9.55 ATM BRCA1 BRCA2 CCND1 TP53
20 DNA double-strand break processing GO:0000729 9.54 ATM BRCA1
21 replicative senescence GO:0090399 9.52 ATM TP53
22 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.49 ESR1 TP53
23 mitotic G1 DNA damage checkpoint GO:0031571 9.48 CCND1 TP53
24 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.43 ATM BRCA1 BRCA2
25 chordate embryonic development GO:0043009 9.32 BRCA1 BRCA2
26 response to estradiol GO:0032355 9.26 BRCA2 CCND1 ESR1 PTEN
27 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.8 BRCA1 BRCA2 TP53

Molecular functions related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.73 ATM BRCA1 BRCA2 ESR1 PGR TP53
2 protein kinase binding GO:0019901 9.46 CCND1 ESR1 PTEN TP53
3 identical protein binding GO:0042802 9.43 BRCA1 BRCA2 ESR1 PGR PTEN TP53
4 steroid binding GO:0005496 9.32 ESR1 PGR
5 enzyme binding GO:0019899 9.1 BRCA1 CCND1 ESR1 PGR PTEN TP53
Sources

Sources for Synchronous Bilateral Breast Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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