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MCID: SYN003
MIFTS: 32

Synchronous Bilateral Breast Carcinoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Synchronous Bilateral Breast Carcinoma

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MalaCards integrated aliases for Synchronous Bilateral Breast Carcinoma:

Name: Synchronous Bilateral Breast Carcinoma 12 15 72

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6742
NCIt 50 C40370
UMLS 72 C1515107
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Summaries for Synchronous Bilateral Breast Carcinoma

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MalaCards based summary : Synchronous Bilateral Breast Carcinoma is related to lymphoma, non-hodgkin, familial and bilateral breast cancer. An important gene associated with Synchronous Bilateral Breast Carcinoma is APPL1 (Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 1), and among its related pathways/superpathways are Cell Cycle, Mitotic and PI3K-Akt signaling pathway. Affiliated tissues include breast, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Synchronous Bilateral Breast Carcinoma

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Diseases related to Synchronous Bilateral Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 lymphoma, non-hodgkin, familial 29.5 TP53 CCND1 ATM
2 bilateral breast cancer 29.4 PGR BRCA2 BRCA1 ATM
3 in situ carcinoma 29.2 TP53 PGR BRCA1
4 breast ductal carcinoma 28.2 TP53 PGR CCND1 BRCA1
5 ductal carcinoma in situ 27.9 TP53 PGR CCND1 BRCA2 BRCA1
6 breast cancer 27.3 TP53 PTEN PGR CCND1 BRCA2 BRCA1
7 sporadic breast cancer 27.2 TP53 PTEN PGR BRCA2 BRCA1 ATM
8 pancreatic neuroendocrine tumor 10.4 BRCA2 ATM
9 skin lipoma 10.4 PTEN APPL1
10 clivus chordoma 10.3 PTEN ATM
11 acinar cell carcinoma 10.2 TP53 BRCA2
12 myxosarcoma 10.2 TP53 ATM
13 richter's syndrome 10.2 TP53 ATM
14 gliomatosis cerebri 10.2 TP53 PTEN
15 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.2 TP53 PTEN
16 breast duct papilloma 10.2 PTEN PGR
17 non-proliferative fibrocystic change of the breast 10.2 TP53 CCND1
18 oral leukoplakia 10.2 TP53 CCND1
19 corneal abscess 10.2 PTEN PGR
20 endometrium carcinoma in situ 10.1 TP53 PGR
21 verrucous carcinoma 10.1 TP53 CCND1
22 hidradenocarcinoma 10.1 TP53 CCND1
23 breast malignant phyllodes tumor 10.1 TP53 PGR
24 olfactory groove meningioma 10.1 TP53 PGR
25 endometrial squamous cell carcinoma 10.1 PGR CCND1
26 bartholin's gland disease 10.1 TP53 PGR
27 hereditary site-specific ovarian cancer syndrome 10.1 BRCA2 BRCA1
28 uterine body mixed cancer 10.1 TP53 PGR
29 keratocystic odontogenic tumor 10.1 TP53 CCND1
30 cervical carcinosarcoma 10.1 TP53 PGR
31 microglandular adenosis 10.1 TP53 PGR
32 anterior cranial fossa meningioma 10.1 TP53 PGR
33 oropharynx cancer 10.1 TP53 CCND1
34 pharynx cancer 10.1 TP53 CCND1
35 tuberculous salpingitis 10.1 BRCA2 BRCA1
36 adenosarcoma 10.1 TP53 PGR
37 laryngeal disease 10.1 TP53 CCND1
38 breast-ovarian cancer, familial 1 10.1 BRCA2 BRCA1
39 ovarian clear cell carcinoma 10.1 TP53 PTEN
40 intestinal benign neoplasm 10.1 TP53 CCND1
41 thoracic benign neoplasm 10.0 TP53 PGR
42 breast benign neoplasm 10.0 TP53 PGR
43 fallopian tube adenocarcinoma 10.0 BRCA2 BRCA1
44 inverted papilloma 10.0 TP53 CCND1
45 penile cancer 10.0 TP53 CCND1
46 peritoneum cancer 10.0 BRCA2 BRCA1
47 mixed cell type cancer 10.0 TP53 PGR
48 premature menopause 10.0 BRCA2 BRCA1
49 fallopian tube disease 10.0 BRCA2 BRCA1
50 giant cell glioblastoma 10.0 TP53 PTEN

Graphical network of the top 20 diseases related to Synchronous Bilateral Breast Carcinoma:



Diseases related to Synchronous Bilateral Breast Carcinoma
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Symptoms & Phenotypes for Synchronous Bilateral Breast Carcinoma

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GenomeRNAi Phenotypes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-2 10.14 BRCA1
2 Decreased viability GR00221-A-3 10.14 APPL1 ATM BRCA1
3 Decreased viability GR00221-A-4 10.14 APPL1 ATM
4 Decreased viability GR00301-A 10.14 BRCA1
5 Decreased viability GR00381-A-1 10.14 APPL1
6 Decreased viability GR00402-S-2 10.14 APPL1 ATM BRCA1
7 Decreased viability in esophageal squamous lineage GR00235-A 9.8 BRCA1 BRCA2 CCND1 PGR PTEN TP53
8 Decreased homologous recombination repair frequency GR00151-A-1 9.76 BRCA1
9 Decreased homologous recombination repair frequency GR00151-A-2 9.76 BRCA1
10 Decreased homologous recombination repair frequency GR00236-A-3 9.76 BRCA1 BRCA2
11 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 ATM BRCA1 BRCA2 PTEN TP53
12 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 ATM BRCA1 BRCA2 PTEN TP53 CCND1
13 Increased cell death HMECs cells GR00103-A-0 9.56 BRCA1 PGR PTEN TP53
14 Decreased viability after ionizing radiation GR00232-A-2 9.54 ATM BRCA1 BRCA2
15 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.46 ATM BRCA1 BRCA2 TP53
16 Decreased TP53 mRNA expression GR00389-S-5 9.43 ATM TP53
17 Synthetic lethal with cisplatin GR00101-A-1 8.96 BRCA1 BRCA2

MGI Mouse Phenotypes related to Synchronous Bilateral Breast Carcinoma:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 APPL1 ATM BRCA1 BRCA2 CCND1 PGR
2 cellular MP:0005384 10.16 APPL1 ATM BRCA1 BRCA2 CCND1 PGR
3 cardiovascular system MP:0005385 10.11 APPL1 ATM BRCA1 CCND1 PGR PTEN
4 hematopoietic system MP:0005397 10.1 APPL1 ATM BRCA1 BRCA2 CCND1 PGR
5 homeostasis/metabolism MP:0005376 10.08 APPL1 ATM BRCA1 BRCA2 CCND1 PGR
6 endocrine/exocrine gland MP:0005379 10.07 ATM BRCA1 BRCA2 CCND1 PGR PTEN
7 immune system MP:0005387 10.06 APPL1 ATM BRCA1 BRCA2 CCND1 PGR
8 growth/size/body region MP:0005378 10.05 APPL1 ATM BRCA1 BRCA2 CCND1 PTEN
9 embryo MP:0005380 10.01 ATM BRCA1 BRCA2 PGR PTEN TP53
10 adipose tissue MP:0005375 9.98 APPL1 ATM BRCA1 PTEN TP53
11 integument MP:0010771 9.98 ATM BRCA1 BRCA2 CCND1 PGR PTEN
12 mortality/aging MP:0010768 9.97 APPL1 ATM BRCA1 BRCA2 CCND1 PGR
13 digestive/alimentary MP:0005381 9.95 BRCA1 BRCA2 CCND1 PTEN TP53
14 limbs/digits/tail MP:0005371 9.8 BRCA1 BRCA2 PGR PTEN TP53
15 neoplasm MP:0002006 9.8 ATM BRCA1 BRCA2 CCND1 PGR PTEN
16 muscle MP:0005369 9.72 APPL1 BRCA1 PGR PTEN TP53
17 normal MP:0002873 9.63 BRCA1 BRCA2 CCND1 PGR PTEN TP53
18 reproductive system MP:0005389 9.5 ATM BRCA1 BRCA2 CCND1 PGR PTEN
19 skeleton MP:0005390 9.1 BRCA1 BRCA2 CCND1 PGR PTEN TP53
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Drugs & Therapeutics for Synchronous Bilateral Breast Carcinoma

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Search Clinical Trials , NIH Clinical Center for Synchronous Bilateral Breast Carcinoma

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Genetic Tests for Synchronous Bilateral Breast Carcinoma

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Anatomical Context for Synchronous Bilateral Breast Carcinoma

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MalaCards organs/tissues related to Synchronous Bilateral Breast Carcinoma:

41
Breast
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Publications for Synchronous Bilateral Breast Carcinoma

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Articles related to Synchronous Bilateral Breast Carcinoma:

(show all 14)
# Title Authors PMID Year
1
Radiation therapy of synchronous bilateral breast carcinoma (SBBC) using multiple techniques. 38
28988893 2018
2
EVOLUTION OF SYNCHRONOUS BILATERAL BREAST CARCINOMA IN A YOUNG PATIENT. 38
27125095 2016
3
Periductal stromal tumor of the breast with synchronous bilateral breast cancer. 38
24982380 2014
4
Synchronous bilateral breast carcinoma and axillary non-hodgkin lymphoma: a case report and review of the literature. 38
23050177 2012
5
Synchronous bilateral breast carcinoma with two different morphology subtypes: a case report. 38
20698158 2010
6
Synchronous bilateral breast carcinoma in a patient with cowden syndrome: a case report with morphologic, immunohistochemical and genetic analysis. 38
19968660 2010
7
Diagnostic and prognostic utility of molecular markers in synchronous bilateral breast carcinoma. 38
18469799 2008
8
Clinicopathological characteristics of synchronous bilateral breast carcinomas. Report of 30 patients. 38
18444533 2008
9
[Synchronous bilateral breast cancer: risk factors, diagnosis, histology and treatment]. 38
18178120 2008
10
Synchronous bilateral breast carcinoma in a 50-year-old man with 45,X/46,XY mosaic karyotype: report of a case. 38
16378198 2006
11
Molecular study of clonality in multifocal and bilateral breast tumors. 38
15648612 2004
12
Histological grade, p53, HER2 and hormone receptor status of synchronous bilateral breast carcinoma. 38
12016392 2002
13
Bilateral breast carcinoma: risk factors and outcomes for patients with synchronous and metachronous disease. 38
10870056 2000
14
Breast-conserving therapy for stage I-II synchronous bilateral breast carcinoma. 38
9083159 1997
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Variations for Synchronous Bilateral Breast Carcinoma

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Expression for Synchronous Bilateral Breast Carcinoma

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Search GEO for disease gene expression data for Synchronous Bilateral Breast Carcinoma.
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Pathways for Synchronous Bilateral Breast Carcinoma

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Pathways related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Cell Cycle, Mitotic 66
Show member pathways
 13.24 TP53 CCND1 BRCA2 BRCA1 ATM
2
PI3K-Akt signaling pathway 37
Show member pathways
 12.86 TP53 PTEN CCND1 BRCA1 ATM
3
Human cytomegalovirus infection 37
Show member pathways
 12.8 TP53 PTEN CCND1 ATM
4
Regulation of TP53 Activity 66
Show member pathways
 12.8 TP53 PTEN BRCA1 ATM
5
TCR Signaling (Qiagen) 64
Show member pathways
 12.75 TP53 BRCA2 BRCA1 ATM
6
Endometrial cancer 37
Show member pathways
 12.73 TP53 PTEN CCND1 BRCA2 APPL1
7
Pathways in cancer 37
12.71 TP53 PTEN CCND1 BRCA2 APPL1
8
Chks in Checkpoint Regulation 64
Show member pathways
 12.56 TP53 CCND1 BRCA2 BRCA1 ATM
9
Gastric cancer 37
Show member pathways
 12.51 TP53 PTEN PGR CCND1 BRCA2 BRCA1
10
Glioma 37
Show member pathways
 12.48 TP53 PTEN CCND1 BRCA2 BRCA1 ATM
11
MicroRNAs in cancer 37
12.4 TP53 PTEN CCND1 BRCA1 ATM
12
DNA Damage 4
12.36 TP53 CCND1 BRCA2 BRCA1 ATM
13
Meiosis 66
Show member pathways
 12.35 BRCA2 BRCA1 ATM
14
Development IGF-1 receptor signaling 22
Show member pathways
 12.26 TP53 PTEN CCND1
15
DNA Double Strand Break Response 66
Show member pathways
 12.23 TP53 BRCA1 ATM
16
Human T-cell leukemia virus 1 infection 37
12.22 TP53 CCND1 ATM
17
Cell cycle 1 37
12.22 TP53 CCND1 ATM
18
DNA Damage Response 1
Show member pathways
 12.22 TP53 PTEN CCND1 BRCA1 ATM
19
Cyclins and Cell Cycle Regulation 64
Show member pathways
 12.21 TP53 CCND1 ATM
20
Homologous DNA Pairing and Strand Exchange 66
Show member pathways
 12.15 BRCA2 BRCA1 ATM
21
Cell cycle Role of SCF complex in cell cycle regulation 22
Show member pathways
 12.08 PGR CCND1 BRCA1
22
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 12.07 TP53 PTEN CCND1
23
Cellular senescence (KEGG) 37
12.07 TP53 PTEN CCND1 ATM
24
Colorectal Cancer Metastasis 64
12.05 TP53 CCND1 APPL1
25
AKT Signaling Pathway 67
11.99 TP53 PTEN CCND1
26
FoxO signaling pathway 37
Show member pathways
 11.96 PTEN CCND1 ATM
27
p53 Signaling 64
Show member pathways
 11.93 TP53 PTEN CCND1 BRCA1 ATM
28
DNA Damage Response (only ATM dependent) 1
11.9 TP53 PTEN CCND1 ATM
29
Glioblastoma Multiforme 64
11.87 TP53 PTEN CCND1
30
Small cell lung cancer 37
11.78 TP53 PTEN CCND1
31
Androgen receptor signaling pathway 1
11.77 PTEN CCND1 BRCA1
32
ATM Pathway 64
Show member pathways
 11.75 TP53 BRCA1 ATM
33
BRCA1 Pathway 64
Show member pathways
 11.7 TP53 BRCA2 BRCA1 ATM
34
Platinum drug resistance 37
11.67 TP53 BRCA1 ATM
35
Coregulation of Androgen receptor activity 1
11.55 CCND1 BRCA1 APPL1
36
Pathways Affected in Adenoid Cystic Carcinoma 1
11.55 TP53 PTEN BRCA1 ATM
37
Copper homeostasis 1
11.52 TP53 PTEN CCND1
38
Hepatitis C and Hepatocellular Carcinoma 1
11.49 TP53 CCND1 BRCA1
39
DNA damage_Role of Brca1 and Brca2 in DNA repair 22
11.48 TP53 BRCA2 BRCA1 ATM
40
miRNAs involved in DNA damage response 1
11.47 TP53 CCND1 ATM
41
Cell cycle Role of 14-3-3 proteins in cell cycle regulation 22
Show member pathways
 11.37 TP53 ATM
42
Integrated Cancer Pathway 1
11.29 TP53 PTEN BRCA1 ATM
43
Integrated Breast Cancer Pathway 1
11.29 TP53 PTEN CCND1 BRCA2 BRCA1 ATM
44
Ovarian tumor domain proteases 66
11.28 TP53 PTEN
45
FOXM1 transcription factor network 1
11.28 CCND1 BRCA2
46
Ovarian Infertility Genes 1
11.2 PGR ATM
47
BARD1 signaling events 1
11.19 TP53 BRCA1 ATM
48
Aurora A signaling 1
11.18 TP53 BRCA1
49
DNA damage_ATM/ATR regulation of G1/S checkpoint 22
11.1 TP53 CCND1 BRCA1 ATM
50
TP53 Network 1
Show member pathways
 11.01 TP53 ATM
Sources

GO Terms for Synchronous Bilateral Breast Carcinoma

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Cellular components related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.76 TP53 PTEN PGR CCND1 BRCA2 BRCA1
2 nucleoplasm GO:0005654 9.17 TP53 PTEN PGR CCND1 BRCA2 BRCA1
3 lateral element GO:0000800 8.96 BRCA2 BRCA1

Biological processes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.86 TP53 PTEN BRCA1 ATM
2 regulation of apoptotic process GO:0042981 9.78 TP53 BRCA1 ATM
3 protein deubiquitination GO:0016579 9.77 TP53 PTEN BRCA1
4 positive regulation of gene expression GO:0010628 9.76 TP53 PTEN BRCA1 ATM
5 cell proliferation GO:0008283 9.71 TP53 PTEN BRCA2 APPL1
6 regulation of cell cycle GO:0051726 9.69 PTEN CCND1 ATM
7 response to ionizing radiation GO:0010212 9.62 BRCA1 ATM
8 nucleotide-excision repair GO:0006289 9.61 TP53 BRCA2
9 response to gamma radiation GO:0010332 9.58 TP53 BRCA2
10 cellular response to gamma radiation GO:0071480 9.58 TP53 ATM
11 cell aging GO:0007569 9.57 TP53 BRCA2
12 positive regulation of cell cycle arrest GO:0071158 9.55 TP53 BRCA1
13 cellular response to DNA damage stimulus GO:0006974 9.55 TP53 CCND1 BRCA2 BRCA1 ATM
14 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.54 TP53 BRCA2
15 response to X-ray GO:0010165 9.52 CCND1 BRCA2
16 DNA double-strand break processing GO:0000729 9.49 BRCA1 ATM
17 replicative senescence GO:0090399 9.48 TP53 ATM
18 response to estradiol GO:0032355 9.43 PTEN CCND1
19 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.43 BRCA2 BRCA1 ATM
20 mitotic G1 DNA damage checkpoint GO:0031571 9.37 TP53 CCND1
21 chordate embryonic development GO:0043009 9.32 BRCA2 BRCA1
22 mammary gland development GO:0030879 9.29 PGR
23 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.13 TP53 BRCA2 BRCA1
24 cell cycle GO:0007049 9.1 TP53 CCND1 BRCA2 BRCA1 ATM APPL1

Molecular functions related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 TP53 PTEN PGR BRCA2 BRCA1 APPL1
2 protein-containing complex binding GO:0044877 9.33 CCND1 ATM APPL1
3 enzyme binding GO:0019899 9.02 TP53 PTEN PGR CCND1 BRCA1
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Sources for Synchronous Bilateral Breast Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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