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MCID: SYN003
MIFTS: 41

Synchronous Bilateral Breast Carcinoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Synchronous Bilateral Breast Carcinoma

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MalaCards integrated aliases for Synchronous Bilateral Breast Carcinoma:

Name: Synchronous Bilateral Breast Carcinoma 12 15 73

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6742
NCIt 50 C40370
UMLS 73 C1515107
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Summaries for Synchronous Bilateral Breast Carcinoma

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MalaCards based summary : Synchronous Bilateral Breast Carcinoma is related to cowden disease and lymphoma, non-hodgkin, familial. An important gene associated with Synchronous Bilateral Breast Carcinoma is ATM (ATM Serine/Threonine Kinase), and among its related pathways/superpathways are Cell Cycle, Mitotic and PI3K-Akt signaling pathway. The drugs Anastrozole and Exemestane have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lymph node, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

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Related Diseases for Synchronous Bilateral Breast Carcinoma

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Diseases related to Synchronous Bilateral Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 cowden disease 30.0 BRCA1 BRCA2 PTEN
2 lymphoma, non-hodgkin, familial 28.6 ATM CCND1 TP53
3 hereditary site-specific ovarian cancer syndrome 10.7 BRCA1 BRCA2
4 breast reconstruction 10.6 BRCA1 BRCA2
5 tuberculous salpingitis 10.6 BRCA1 BRCA2
6 breast-ovarian cancer, familial 1 10.6 BRCA1 BRCA2
7 peritoneum cancer 10.6 BRCA1 BRCA2
8 breast duct papilloma 10.6 PGR PTEN
9 premature menopause 10.6 BRCA1 BRCA2
10 clear cell adenofibroma 10.5 BRCA1 BRCA2
11 corneal abscess 10.5 PGR PTEN
12 cystadenofibroma 10.5 BRCA1 BRCA2
13 lynch syndrome i 10.5 BRCA1 BRCA2
14 breast giant fibroadenoma 10.4 BRCA2 ESR1
15 vulvar syringoma 10.4 ESR1 PGR
16 lung leiomyoma 10.4 ESR1 PGR
17 glassy cell carcinoma of the cervix 10.4 ESR1 PGR
18 vulvar benign neoplasm 10.4 ESR1 PGR
19 trigonitis 10.4 ESR1 PGR
20 tetraploidy 10.4 BRCA2 TP53
21 vulvar leiomyoma 10.4 ESR1 PGR
22 predominantly cortical thymoma 10.4 ESR1 PGR
23 breast scirrhous carcinoma 10.4 ESR1 PGR
24 progesterone resistance 10.4 ESR1 PGR
25 progesterone-receptor positive breast cancer 10.4 ESR1 PGR
26 cribriform carcinoma 10.4 ESR1 PGR
27 oncocytic breast carcinoma 10.4 ESR1 PGR
28 gastric signet ring cell adenocarcinoma 10.3 ESR1 PGR
29 endometrial mucinous adenocarcinoma 10.3 ESR1 PGR
30 adenoid basal cell carcinoma 10.3 ESR1 PGR
31 apocrine adenocarcinoma 10.3 ESR1 PGR
32 gender identity disorder 10.3 ESR1 PGR
33 deep angioma 10.3 ESR1 PGR
34 breast adenoid cystic carcinoma 10.3 ESR1 PGR
35 lobular neoplasia 10.3 BRCA1 ESR1
36 estrogen excess 10.3 ESR1 PGR
37 intramuscular hemangioma 10.3 ESR1 PGR
38 mammographic density 10.3 ESR1 PGR
39 retinitis pigmentosa 47 10.3 ESR1 PGR
40 adenomyosis 10.3 ESR1 PGR
41 retinitis pigmentosa 20 10.3 ESR1 PGR
42 luminal breast carcinoma 10.3 ESR1 PGR
43 endometrium carcinoma in situ 10.3 PGR TP53
44 cervical clear cell adenocarcinoma 10.3 ESR1 PGR
45 endometriosis of ovary 10.3 ESR1 PGR
46 inflammatory breast carcinoma 10.3 ESR1 PGR
47 richter's syndrome 10.2 ATM TP53
48 gliomatosis cerebri 10.2 PTEN TP53
49 breast malignant phyllodes tumor 10.2 PGR TP53
50 olfactory groove meningioma 10.2 PGR TP53

Graphical network of the top 20 diseases related to Synchronous Bilateral Breast Carcinoma:



Diseases related to Synchronous Bilateral Breast Carcinoma
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Symptoms & Phenotypes for Synchronous Bilateral Breast Carcinoma

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GenomeRNAi Phenotypes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.2 BRCA1
2 Decreased homologous recombination repair frequency GR00151-A-2 10.2 BRCA1
3 Decreased homologous recombination repair frequency GR00236-A-1 10.2 BRCA1 BRCA2 PGR
4 Decreased homologous recombination repair frequency GR00236-A-2 10.2 BRCA2 ATM PGR BRCA1
5 Decreased homologous recombination repair frequency GR00236-A-3 10.2 BRCA2 BRCA1
6 Decreased viability in esophageal squamous lineage GR00235-A 9.97 SLC5A7 TP53 BRCA2 CCND1 ESR1 BRCA1
7 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 TP53 BRCA2 ATM BRCA1 PTEN
8 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 TP53 BRCA2 ATM CCND1 BRCA1 PTEN
9 Increased cell death HMECs cells GR00103-A-0 9.62 TP53 PTEN PGR BRCA1
10 Decreased viability after ionizing radiation GR00232-A-2 9.58 BRCA2 ATM BRCA1
11 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.46 TP53 BRCA1 BRCA2 ATM
12 Decreased TP53 mRNA expression GR00389-S-5 9.43 TP53 ATM
13 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.43 PTEN CCND1 ESR1
14 Synthetic lethal with cisplatin GR00101-A-1 8.96 BRCA2 BRCA1

MGI Mouse Phenotypes related to Synchronous Bilateral Breast Carcinoma:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.24 CCND1 PGR ESR1 PTEN TP53 SLC5A7
2 endocrine/exocrine gland MP:0005379 10.2 PGR ESR1 PTEN TP53 SLC5A7 CCND1
3 cardiovascular system MP:0005385 10.19 CCND1 PGR ESR1 PTEN TP53 SLC5A7
4 cellular MP:0005384 10.18 ESR1 CCND1 PGR PTEN TP53 BRCA2
5 hematopoietic system MP:0005397 10.18 CCND1 PGR ESR1 PTEN TP53 SLC5A7
6 homeostasis/metabolism MP:0005376 10.16 CCND1 PGR ESR1 PTEN TP53 SLC5A7
7 immune system MP:0005387 10.15 CCND1 PGR ESR1 PTEN TP53 SLC5A7
8 integument MP:0010771 10.13 PGR ESR1 PTEN TP53 SLC5A7 CCND1
9 digestive/alimentary MP:0005381 10.11 CCND1 ESR1 PTEN TP53 SLC5A7 BRCA1
10 embryo MP:0005380 10.1 PGR ESR1 PTEN TP53 BRCA1 ATM
11 mortality/aging MP:0010768 10.09 ESR1 CCND1 PGR PTEN TP53 SLC5A7
12 growth/size/body region MP:0005378 10.08 ESR1 CCND1 PTEN TP53 BRCA2 BRCA1
13 adipose tissue MP:0005375 10 ESR1 PTEN TP53 BRCA1 ATM
14 neoplasm MP:0002006 9.97 PGR ESR1 PTEN TP53 CCND1 ATM
15 limbs/digits/tail MP:0005371 9.93 PGR ESR1 PTEN TP53 BRCA2 BRCA1
16 nervous system MP:0003631 9.92 ESR1 CCND1 PTEN TP53 SLC5A7 BRCA2
17 normal MP:0002873 9.86 PTEN CCND1 PGR ESR1 TP53 SLC5A7
18 muscle MP:0005369 9.8 ESR1 PGR PTEN TP53 BRCA1
19 reproductive system MP:0005389 9.76 CCND1 PGR ESR1 PTEN TP53 BRCA1
20 respiratory system MP:0005388 9.43 ESR1 CCND1 PTEN TP53 SLC5A7 BRCA1
21 skeleton MP:0005390 9.17 ESR1 CCND1 PGR PTEN TP53 BRCA2
Sources

Drugs & Therapeutics for Synchronous Bilateral Breast Carcinoma

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Drugs for Synchronous Bilateral Breast Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
2
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
3
Tamoxifen Approved Phase 3 10540-29-1 2733526
4
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
5
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
6 Chelating Agents Phase 3
7 Selective Estrogen Receptor Modulators Phase 3
8 Steroid Synthesis Inhibitors Phase 3
9 Hormone Antagonists Phase 3
10 Hormones Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
12 Estrogen Antagonists Phase 3
13 Estrogen Receptor Modulators Phase 3
14 Estrogens Phase 3
15 Anticoagulants Phase 3
16 Aromatase Inhibitors Phase 3
17 Bone Density Conservation Agents Phase 3
18 Calcium, Dietary Phase 3
19 Antineoplastic Agents, Hormonal Phase 3
20 Citrate Nutraceutical Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Active, not recruiting NCT01272037 Phase 3 Anastrozole;Exemestane;Letrozole;Systemic Chemotherapy;Tamoxifen Citrate

Search NIH Clinical Center for Synchronous Bilateral Breast Carcinoma

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Genetic Tests for Synchronous Bilateral Breast Carcinoma

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Anatomical Context for Synchronous Bilateral Breast Carcinoma

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MalaCards organs/tissues related to Synchronous Bilateral Breast Carcinoma:

41
Bone, Breast, Lymph Node
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Publications for Synchronous Bilateral Breast Carcinoma

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Articles related to Synchronous Bilateral Breast Carcinoma:

# Title Authors Year
1
Radiation therapy of synchronous bilateral breast carcinoma (SBBC) using multiple techniques. ( 28988893 )
2018
2
EVOLUTION OF SYNCHRONOUS BILATERAL BREAST CARCINOMA IN A YOUNG PATIENT. ( 27125095 )
2016
3
Synchronous bilateral breast carcinoma and axillary non-hodgkin lymphoma: a case report and review of the literature. ( 23050177 )
2012
4
Synchronous bilateral breast carcinoma in a patient with cowden syndrome: a case report with morphologic, immunohistochemical and genetic analysis. ( 19968660 )
2010
5
Synchronous bilateral breast carcinoma with two different morphology subtypes: a case report. ( 20698158 )
2010
6
Diagnostic and prognostic utility of molecular markers in synchronous bilateral breast carcinoma. ( 18469799 )
2008
7
Synchronous bilateral breast carcinoma in a 50-year-old man with 45,X/46,XY mosaic karyotype: report of a case. ( 16378198 )
2006
8
Histological grade, p53, HER2 and hormone receptor status of synchronous bilateral breast carcinoma. ( 12016392 )
2002
9
Cytogenetic heterogeneity and clonal evolution in synchronous bilateral breast carcinomas and their lymph node metastases from a male patient without any detectable BRCA2 germline mutation. ( 10731589 )
2000
10
Breast-conserving therapy for stage I-II synchronous bilateral breast carcinoma. ( 9083159 )
1997
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Variations for Synchronous Bilateral Breast Carcinoma

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Expression for Synchronous Bilateral Breast Carcinoma

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Search GEO for disease gene expression data for Synchronous Bilateral Breast Carcinoma.
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Pathways for Synchronous Bilateral Breast Carcinoma

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Pathways related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Cell Cycle, Mitotic 66
Show member pathways
 13.27 ATM BRCA1 BRCA2 CCND1 TP53
2
PI3K-Akt signaling pathway 37
Show member pathways
 12.85 ATM BRCA1 CCND1 PTEN TP53
3
Regulation of TP53 Activity 66
Show member pathways
 12.82 ATM BRCA1 PTEN TP53
4
TCR Signaling (Qiagen) 64
Show member pathways
 12.77 ATM BRCA1 BRCA2 TP53
5
Endometrial cancer 37
Show member pathways
 12.72 BRCA2 CCND1 PTEN TP53
6
Pathways in cancer 37
12.72 BRCA2 CCND1 ESR1 PTEN TP53
7
Deubiquitination 66
Show member pathways
 12.69 BRCA1 ESR1 PTEN TP53
8
Chks in Checkpoint Regulation 64
Show member pathways
 12.49 ATM BRCA1 BRCA2 CCND1 ESR1 TP53
9
MicroRNAs in cancer 37
12.4 ATM BRCA1 CCND1 PTEN TP53
10
DNA Damage 4
12.38 ATM BRCA1 BRCA2 CCND1 TP53
11
Glioma 37
Show member pathways
 12.37 ATM BRCA1 BRCA2 CCND1 ESR1 PTEN
12
HTLV-I infection 37
12.3 ATM CCND1 TP53
13
Cell cycle 1 37
12.24 ATM CCND1 TP53
14
DNA Double Strand Break Response 66
Show member pathways
 12.24 ATM BRCA1 TP53
15
DNA Damage Response 1
Show member pathways
 12.24 ATM BRCA1 CCND1 PTEN TP53
16
Cyclins and Cell Cycle Regulation 64
Show member pathways
 12.23 ATM CCND1 TP53
17
Proteoglycans in cancer 37
12.17 CCND1 ESR1 TP53
18
Gastric cancer 37
Show member pathways
 12.17 BRCA1 BRCA2 CCND1 ESR1 PGR PTEN
19
Homologous DNA Pairing and Strand Exchange 66
Show member pathways
 12.16 ATM BRCA1 BRCA2
20
Cell cycle Role of SCF complex in cell cycle regulation 22
Show member pathways
 12.14 BRCA1 CCND1 ESR1 PGR
21
p53 Signaling 64
Show member pathways
 12.1 ATM BRCA1 CCND1 PTEN TP53
22
Cellular senescence (KEGG) 37
12.07 ATM CCND1 PTEN TP53
23
AKT Signaling Pathway 67
12.02 CCND1 PTEN TP53
24
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 66
Show member pathways
 12.02 ATM BRCA1 BRCA2
25
FoxO signaling pathway 37
Show member pathways
 11.98 ATM CCND1 PTEN
26
Development IGF-1 receptor signaling 22
Show member pathways
 11.94 CCND1 PTEN TP53
27
DNA Damage Response (only ATM dependent) 1
11.91 ATM CCND1 PTEN TP53
28
Thyroid hormone signaling pathway 37
11.9 CCND1 ESR1 TP53
29
Glioblastoma Multiforme 64
11.87 CCND1 PTEN TP53
30
Small cell lung cancer 37
11.79 CCND1 PTEN TP53
31
Androgen receptor signaling pathway 1
11.78 BRCA1 CCND1 PTEN
32
ATM Pathway 64
Show member pathways
 11.75 ATM BRCA1 TP53
33
BRCA1 Pathway 64
Show member pathways
 11.71 ATM BRCA1 BRCA2 TP53
34
Platinum drug resistance 37
11.67 ATM BRCA1 TP53
35
Regulation of Telomerase 1
11.62 ATM CCND1 ESR1
36
Pathways Affected in Adenoid Cystic Carcinoma 1
11.58 ATM BRCA1 PTEN TP53
37
Copper homeostasis 1
11.53 CCND1 PTEN TP53
38
Hepatitis C and Hepatocellular Carcinoma 1
11.49 BRCA1 CCND1 TP53
39
miRNAs involved in DNA damage response 1
11.48 ATM CCND1 TP53
40
Integrated Breast Cancer Pathway 1
11.35 ATM BRCA1 BRCA2 CCND1 ESR1 PTEN
41
FOXM1 transcription factor network 1
11.33 BRCA2 CCND1 ESR1
42
Integrated Cancer Pathway 1
11.33 ATM BRCA1 PTEN TP53
43
Ovarian tumor domain proteases 66
11.32 ESR1 PTEN TP53
44
DNA damage_ATM/ATR regulation of G1/S checkpoint 22
11.27 ATM BRCA1 CCND1 TP53
45
Signaling mediated by p38-alpha and p38-beta 1
11.26 ESR1 TP53
46
Ovarian Infertility Genes 1
11.21 ATM PGR
47
BARD1 signaling events 1
11.2 ATM BRCA1 TP53
48
Aurora A signaling 1
11.19 BRCA1 TP53
49
GADD45 Pathway 64
11.06 ATM BRCA1 CCND1 TP53
50
MNAR-PELP1 and Estrogen Receptor Interaction 64
11.04 CCND1 ESR1
Sources

GO Terms for Synchronous Bilateral Breast Carcinoma

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Cellular components related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.46 BRCA1 BRCA2 ESR1 TP53
2 nucleoplasm GO:0005654 9.23 ATM BRCA1 BRCA2 CCND1 ESR1 PGR
3 lateral element GO:0000800 8.96 BRCA1 BRCA2

Biological processes related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.95 ATM BRCA1 PTEN TP53
2 positive regulation of transcription, DNA-templated GO:0045893 9.92 BRCA1 BRCA2 ESR1 TP53
3 cell cycle GO:0007049 9.83 ATM BRCA1 BRCA2 CCND1 TP53
4 regulation of apoptotic process GO:0042981 9.81 ATM BRCA1 ESR1 TP53
5 transcription initiation from RNA polymerase II promoter GO:0006367 9.78 CCND1 ESR1 PGR
6 protein deubiquitination GO:0016579 9.78 BRCA1 ESR1 PTEN TP53
7 regulation of signal transduction by p53 class mediator GO:1901796 9.76 ATM BRCA1 TP53
8 regulation of cell cycle GO:0051726 9.75 ATM CCND1 PTEN
9 cellular response to DNA damage stimulus GO:0006974 9.72 ATM BRCA1 BRCA2 CCND1 TP53
10 response to estradiol GO:0032355 9.7 CCND1 ESR1 PTEN
11 double-strand break repair via homologous recombination GO:0000724 9.67 ATM BRCA1 BRCA2
12 response to gamma radiation GO:0010332 9.64 BRCA2 TP53
13 cell aging GO:0007569 9.64 BRCA2 TP53
14 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.63 BRCA2 TP53
15 positive regulation of cell cycle arrest GO:0071158 9.63 BRCA1 TP53
16 response to estrogen GO:0043627 9.63 BRCA1 CCND1 ESR1
17 cellular response to gamma radiation GO:0071480 9.62 ATM TP53
18 female gonad development GO:0008585 9.61 ATM BRCA2
19 mammary gland alveolus development GO:0060749 9.6 CCND1 ESR1
20 DNA double-strand break processing GO:0000729 9.59 ATM BRCA1
21 replicative senescence GO:0090399 9.57 ATM TP53
22 determination of adult lifespan GO:0008340 9.56 ATM TP53
23 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.55 ESR1 TP53
24 mitotic G1 DNA damage checkpoint GO:0031571 9.54 CCND1 TP53
25 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.54 ATM BRCA1 BRCA2
26 DNA synthesis involved in DNA repair GO:0000731 9.43 ATM BRCA1 BRCA2
27 chordate embryonic development GO:0043009 9.4 BRCA1 BRCA2
28 strand displacement GO:0000732 9.33 ATM BRCA1 BRCA2
29 response to X-ray GO:0010165 9.13 BRCA2 CCND1 TP53
30 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.8 BRCA1 BRCA2 TP53
31 regulation of transcription, DNA-templated GO:0006355 10.13 BRCA1 BRCA2 CCND1 ESR1 PGR TP53

Molecular functions related to Synchronous Bilateral Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.73 ATM BRCA1 BRCA2 ESR1 PGR TP53
2 identical protein binding GO:0042802 9.55 BRCA2 ESR1 PGR PTEN TP53
3 steroid binding GO:0005496 9.32 ESR1 PGR
4 protein kinase binding GO:0019901 9.26 CCND1 ESR1 PTEN TP53
5 enzyme binding GO:0019899 9.1 BRCA1 CCND1 ESR1 PGR PTEN TP53
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Sources for Synchronous Bilateral Breast Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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