Syncope disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SYN036 MIFTS: 46	Syncope Categories: Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Syncope

MalaCards integrated aliases for Syncope:

Name: Syncope ⁵² ⁷⁵ ²⁸ ⁵ ⁷⁵

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD11: ³³

Diseases of the nervous system

Disorders of autonomic nervous system

Disorders of orthostatic tolerance

Syncope due to autonomic failure

External Ids:

ICD11 ³³ 177994271

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Summaries for Syncope

NINDS: ⁵² Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or “passing out.” If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may “white out” or “black out.” The skin may be cold and clammy. The person drops to the floor as he or she loses consciousness. After fainting, an individual may be unconscious for a minute or two, but will revive and slowly return to normal. Syncope can occur in otherwise healthy people and affects all age groups, but occurs more often in the elderly. There are several types of syncope. Vasovagal syncope usually has an easily identified triggering event such as emotional stress, trauma, pain, the sight of blood, or prolonged standing. Carotid sinus syncope happens because of constriction of the carotid artery in the neck and can occur after turning the head, while shaving, or when wearing a tight collar. Situational syncope happens during urination, defecation, coughing, or as a result of gastrointestinal stimulation. Syncope can also be a symptom of heart disease or abnormalities that create an uneven heart rate or rhythm that temporarily affect blood volume and its distribution in the body. Syncope isn’t normally a primary sign of a neurological disorder, but it may indicate an increased risk for neurologic disorders such as Parkinson’s disease, postural orthostatic tachycardia syndrome (POTS), diabetic neuropathy, and other types of neuropathy. Certain classes of drugs are associated with an increased risk of syncope, including diuretics, calcium antagonists, ACE inhibitors, nitrates, antipsychotics, antihistamines, levodopa, narcotics, and alcohol.

MalaCards based summary: Syncope is related to second-degree atrioventricular block and first-degree atrioventricular block. An important gene associated with Syncope is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Cardiac conduction and Dopamine-DARPP32 Feedback onto cAMP Pathway. The drugs Propranolol and Midodrine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and skin, and related phenotypes are nervous system and normal

Wikipedia: ⁷⁵ Syncope, commonly known as fainting, or passing out, is a loss of consciousness and muscle strength... more...

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Related Diseases for Syncope

Diseases related to Syncope via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)

#	Related Disease	Score	Top Affiliating Genes
1	second-degree atrioventricular block	10.2	SCN5A KCNH2
2	first-degree atrioventricular block	10.2	SCN5A KCNH2
3	familial short qt syndrome	10.2	KCNQ1 KCNH2
4	progressive familial heart block	10.2	SCN5A KCNQ1
5	diamond-blackfan anemia 3	10.2	SCN5A KCNH2
6	trichothiodystrophy 7, nonphotosensitive	10.2	SCN5A KCNH2
7	cardiomyopathy, dilated, with woolly hair and keratoderma	10.1	SCN5A RYR2
8	atrial standstill 1	10.1	SCN5A EDN1
9	familial long qt syndrome	10.1	SCN5A KCNQ1 KCNH2
10	anhidrosis, isolated, with normal sweat glands	10.1	RYR2 EDN1
11	long qt syndrome 6	10.1	SCN5A KCNQ1 KCNH2
12	long qt syndrome 14	10.1	SCN5A KCNQ1 KCNH2
13	long qt syndrome 12	10.1	SCN5A KCNQ1 KCNH2
14	brugada syndrome 4	10.1	SCN5A KCNQ1 KCNH2
15	long qt syndrome 13	10.1	SCN5A KCNQ1 KCNH2
16	long qt syndrome 5	10.1	SCN5A KCNQ1 KCNH2
17	developmental and epileptic encephalopathy 14	10.1	SCN5A KCNQ1 KCNH2
18	naxos disease	10.1	SCN5A RYR2
19	atrial standstill	10.1	SCN5A NPPA
20	dopamine beta-hydroxylase deficiency	10.1	SLC6A2 DBH
21	palmoplantar keratoderma, nonepidermolytic	10.1	SCN5A RYR2
22	oppositional defiant disorder	10.0	SLC6A2 DBH
23	brugada syndrome 1	10.0	SCN5A RYR2 KCNH2
24	cardiac conduction defect	10.0	SCN5A RYR2 KCNQ1
25	mitral valve stenosis	10.0	NPPA EDN1
26	renovascular hypertension	10.0	NPPA EDN1
27	progressive familial heart block, type ii	10.0	TNNT2 SCN5A
28	renal hypertension	10.0	EDN1 DBH
29	cocaine abuse	10.0	SLC6A2 DBH
30	hepatorenal syndrome	9.9	NPPA EDN1
31	cardiomyopathy, dilated, 1b	9.9	TNNT2 SCN5A
32	diastolic heart failure	9.9	TNNT2 EDN1
33	coronary artery vasospasm	9.9	TNNT2 EDN1
34	myocardial stunning	9.9	TNNT2 EDN1
35	systolic heart failure	9.9	TNNT2 EDN1
36	sinoatrial node disease	9.9	SCN5A RYR2 KCNQ1 KCNH2
37	long qt syndrome 9	9.9	SCN5A RYR2 KCNQ1 KCNH2
38	short qt syndrome	9.9	SCN5A RYR2 KCNQ1 KCNH2
39	long qt syndrome 3	9.9	SCN5A RYR2 KCNQ1 KCNH2
40	timothy syndrome	9.9	SCN5A RYR2 KCNQ1 KCNH2
41	tricuspid valve insufficiency	9.9	TNNT2 EDN1
42	andersen cardiodysrhythmic periodic paralysis	9.9	SCN5A RYR2 KCNQ1 KCNH2
43	cardiac arrhythmia, ankyrin-b-related	9.9	SCN5A RYR2 KCNQ1 KCNH2
44	jervell and lange-nielsen syndrome 1	9.9	SCN5A RYR2 KCNQ1 KCNH2
45	cardiomyopathy, dilated, 1dd	9.9	TNNT2 RYR2
46	third-degree atrioventricular block	9.9	SCN5A RYR2 KCNQ1 KCNH2
47	long qt syndrome 2	9.9	SCN5A RYR2 KCNQ1 KCNH2
48	nonobstructive coronary artery disease	9.9	TNNT2 EDN1
49	mood disorder	9.9	SLC6A2 GNB3 DBH
50	tricuspid valve disease	9.9	TNNT2 EDN1

Graphical network of the top 20 diseases related to Syncope:

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Symptoms & Phenotypes for Syncope

MGI Mouse Phenotypes related to Syncope:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.86	DBH EDN1 GNB3 KCNQ1 RYR2 SCN5A
2	normal	MP:0002873	9.8	DBH EDN1 KCNQ1 RYR2 SCN5A TNNT2
3	muscle	MP:0005369	9.7	EDN1 KCNH2 KCNQ1 NPPA RYR2 SCN5A
4	cardiovascular system	MP:0005385	9.61	DBH EDN1 KCNH2 KCNQ1 NPPA RYR2
5	mortality/aging	MP:0010768	9.28	ACTL6A DBH EDN1 GNB3 KCNH2 RYR2

Sources

Drugs & Therapeutics for Syncope

Drugs for Syncope (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Propranolol

Approved, Investigational

Phase 4

318-98-9, 525-66-6

62882 4946

Midodrine

Approved

Phase 4

133163-28-7, 42794-76-3

4195

Metoprolol

Approved, Investigational

Phase 4

37350-58-6, 51384-51-1

4171

Vasodilator Agents

Phase 4

Neurotransmitter Agents

Phase 4

Adrenergic alpha-Agonists

Phase 4

Adrenergic Agonists

Phase 4

Vasoconstrictor Agents

Phase 4

Sympathomimetics

Phase 4

Antihypertensive Agents

Phase 4

Anti-Arrhythmia Agents

Phase 4

Adrenergic beta-Antagonists

Phase 4

Adrenergic beta-1 Receptor Antagonists

Phase 4

Adrenergic Antagonists

Phase 4

Sympatholytics

Phase 4

Levodopa

Approved

Phase 3

59-92-7, 63-84-3

6047

Dopamine

Approved

Phase 3

62-31-7, 51-61-6

681

Cephalexin

Approved, Investigational, Vet_approved

Phase 3

15686-71-2

27447

Bacitracin

Approved, Vet_approved

Phase 3

1405-87-4

10909430

Levofloxacin

Approved, Investigational

Phase 3

100986-85-4

149096

Polymyxin B

Approved, Vet_approved

Phase 3

1405-20-5, 1404-26-8

4868

Ofloxacin

Approved

Phase 3

82419-36-1

4583

Clindamycin

Approved, Vet_approved

Phase 3

18323-44-9, 24729-96-2

29029

Fludrocortisone

Approved, Investigational

Phase 3

127-31-1

31378

Atomoxetine

Approved

Phase 3

82248-59-7, 83015-26-3

54841

Antiparkinson Agents

Phase 3

Dihydroxyphenylalanine

Phase 3

Dopamine Agents

Phase 3

Antipsychotic Agents

Phase 3

Psychotropic Drugs

Phase 3

Antidepressive Agents

Phase 3

diuretics

Phase 3

Antibiotics, Antitubercular

Phase 3

Anti-Bacterial Agents

Phase 3

Anti-Infective Agents

Phase 3

Polymyxins

Phase 3

Anti-Infective Agents, Local

Phase 3

Cytochrome P-450 Enzyme Inhibitors

Phase 3

Clindamycin phosphate

Phase 3

32603

Clindamycin palmitate

Phase 3

Anti-Inflammatory Agents

Phase 3

Norepinephrine

Approved

Phase 2

51-41-2

439260

Acarbose

Approved, Investigational

Phase 2

56180-94-0

441184 444254

Caffeine

Approved

Phase 2

58-08-2

2519

Capsaicin

Approved

Phase 2

404-86-4

1548943

Droxidopa

Approved, Investigational

Phase 2

23651-95-8

443940 92974

Hypoglycemic Agents

Phase 2

Cardiac Glycosides

Phase 2

Glycoside Hydrolase Inhibitors

Phase 2

Central Nervous System Stimulants

Phase 2

Interventional clinical trials:

(show top 50) (show all 184)

#	Name	Status	NCT ID	Phase	Drugs
1	Closed Loop Stimulation for Neuromediated Syncope	Unknown status	NCT01621464	Phase 4
2	A Randomized Clinical Trial of Fludrocortisone for Vasovagal Syncope: The Second Prevention of Syncope Trial (POST II)	Completed	NCT00118482	Phase 4	fludrocortisone acetate
3	ISSUE3: International Study on Syncope of Uncertain Etiology 3 Pacemaker Therapy for Patients With Asystolic Neurally-mediated Syncope	Completed	NCT00359203	Phase 4
4	Propranolol for Syncope With Sympathoadrenal Imbalance	Completed	NCT00060866	Phase 4	Propranolol
5	Early Loop-Recorder in Suspected Arrhythmogenic Syncope	Completed	NCT00170261	Phase 4
6	Syncope: Pacing or Recording in the Later Years (SPRITELY)	Completed	NCT01423994	Phase 4
7	Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV (Post 4)	Active, not recruiting	NCT01456481	Phase 4	midodrine hydrochloride;matching placebo
8	Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects	Active, not recruiting	NCT02123056	Phase 4	Metoprolol;Matching Placebo
9	Randomized Controlled Trial on Discontinuation of Vasoactive Drugs in Patients With Hypotensive Reflex Syncope	Completed	NCT02137278	Phase 3	Vasoactive drug therapies
10	Randomized Noninferiority Study of an Antibacterial Envelope Alone Versus Envelope Plus Intraoperative Antibacterial Irrigant and Postoperative Antibiotics to Prevent Cardiac Implantable Electronic Device Infections in High-Risk Patients	Completed	NCT02809131	Phase 3	polymixin/bacitracin;cephalexin, or levofloxacin, or clindamycin;Saline
11	Comparison of Outcomes With Midodrine and Fludrocortisone for Objective Recurrence in Treating Syncope (COMFORTS Trial)	Recruiting	NCT04595942	Phase 3	Midodrine Hydrochloride Tablets;Fludrocortisone Acetate Tablets
12	A Randomized, Prospective, Placebo-Controlled, Crossover Study of Atomoxetine in the Prevention of Vasovagal Syncope (POST7)	Recruiting	NCT05159687	Phase 3	Atomoxetine Hydrochloride;Placebo
13	Benefit of Controlled Rehydration in Unexplained Syncope	Terminated	NCT00143754	Phase 3
14	A Proof of Principle Study of Atomoxetine for the Prevention of Vasovagal Syncope (VVS): POST6	Completed	NCT02500732	Phase 2	Atomoxetine;Placebo
15	Preventing Adverse Reactions in Novice Blood Donors	Completed	NCT00302900	Phase 2
16	Non-Pharmacologic Therapy for Neurocardiogenic Syncope	Completed	NCT00096902	Phase 2
17	Propranolol for Syncope With Sympathoadrenal Imbalance in Children	Completed	NCT00093860	Phase 2	Propranolol
18	Acarbose and Older Adults With Postprandial Hypotension	Completed	NCT01914133	Phase 2	Acarbose;Placebo
19	The Effect of Capsaicin-Phenylephrine-Caffeine Formulation on Aborting Tilt Induced Syncope in Patients With a History of Vasovagal Syncope	Recruiting	NCT04972123	Phase 2	CPC - Capsaicin, Phenylephrine, Caffeine;Placebo
20	Northera Improves Postural Tachycardia Syndrome (POTS) and Postural	Active, not recruiting	NCT02558972	Phase 2	Northera (Droxidopa);Placebo
21	ELectrophysiological Mechanisms Underlying the Inhibitory CArdiac Syncope: Therapeutic and Prognostic Implications The ELICA Study	Completed	NCT02861274	Phase 1
22	Reducing Orthostatic Intolerance With Oral Rehydration in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome	Active, not recruiting	NCT02854683	Phase 1	Normal Saline
23	EXercise for the Prevention of Syncope Evaluation	Suspended	NCT00203593	Phase 1
24	Optimizing Diagnostics And Therapy Of Arrhythmia And Syncope Events Using Intelligent Telemetric Solutions. Diagnostics Of Syncope In Children.	Unknown status	NCT01265290
25	Evaluation of a Mobile Cardiac Outpatient Telemetry System (CardioNet) Versus Standard Loop Event Monitor: A Multi-Center Randomized Study	Unknown status	NCT00295204
26	Effect of Dietary Salt Supplemantation in Vasovagal Syncope Prophylaxis: A Clinical Trial	Unknown status	NCT00465946
27	Management of Sleep Apnoea Syndrome (SAS) in Patients With Vasovagal Syncope (VVS): a Protocol for the VVS-SAS Registry Study	Unknown status	NCT04294524
28	Respiration and Applied Tension Strategies to Reduce Vasovagal Reactions to Blood Donation	Unknown status	NCT03159156
29	The Iliac Arterio-venous Fistula for Treatment of Neurally Mediated Syncope Study	Unknown status	NCT02388087
30	Risk of Syncopal Relapses in Patients Treated With Permanent Pacing for Bradyarrhythmic Syncope	Unknown status	NCT04229589
31	Assessing the Risk of Pulmonary Embolism in Patients After Hospitalization for First Episode of Syncope	Unknown status	NCT03034525
32	Bradycardia High Risk Patient Identification After Syncope With Loop Recorder an Observational Study in Nancy University Hospital	Unknown status	NCT04200014
33	Eastbourne Syncope Assessment Study II	Unknown status	NCT00517023
34	Hypersensitive Troponin Performance to Identify Syncope at Risk of Serious Adverse Events in the Short Term	Unknown status	NCT03528161
35	OPTIMIZING DIAGNOSTICS AND THERAPY OF ARRHYTHMIA AND SYNCOPE EVENTS USING INTELLIGENT TELEMETRIC SOLUTIONS - Evaluation of Arrhythmia Treatment Efficacy	Unknown status	NCT01265303
36	Optimizing Diagnostics And Therapy Of Arrhythmia And Syncope Events Using Intelligent Telemetric Solutions. Diagnostics Of Arrhythmia In Children	Unknown status	NCT01265771
37	OPTIMIZING DIAGNOSTICS AND THERAPY OF ARRHYTHMIA AND SYNCOPE EVENTS USING INTELLIGENT TELEMETRIC SOLUTIONS - Evaluation of Arrhythmia Diagnostics in Adults	Unknown status	NCT01265758
38	Serum Lactate in Convulsive Syncopes Compared to Non-convulsive Syncopes	Unknown status	NCT03062683
39	EPIcardial and Endocardial Mapping and Ablation Using Contact Force Catheter in Chagasic Patients With Sustained Ventricular Tachycardia	Unknown status	NCT01847378
40	Registry Of Acute meDical Emergencies in Brazil - ROAD-Brazil	Unknown status	NCT02753023
41	Comparison of a Sternal ECG Patch With a Standard Recording System for Holter Monitoring	Unknown status	NCT02126631
42	REVEAL for Respiration Detection	Unknown status	NCT01956578
43	Observational Study of the Sleuth Implantable ECG Monitoring System	Unknown status	NCT00717106
44	Comparison of Continuous Sternal ECG Patch Monitors (Carnation and Zio) Trial	Unknown status	NCT02031484
45	Evaluation of a New Cardiac Pacemaker	Unknown status	NCT01700244
46	Pilot Clinical Study of the Sleuth Implantable ECG Monitoring System	Unknown status	NCT00719277
47	A Survey of Hospitalizations in Cardiology Units in Sub-Saharan Africa	Unknown status	NCT03231449
48	NICE Guideline 'Red Flags' to Predict Serious Outcome After Transient Loss of Consciousness: Prospective Validation Study in the Emergency Department.	Unknown status	NCT01498471
49	CardioneuROablation for Reflex Syncope: Effects on autonoMic cArdiac Regulation and Efficacy Assessment - the Roman Syncope Study.	Completed	NCT03903744
50	Effect of Pacemaker With Closed Loop Sensor on Quality of Life and Recurrence of Syncope in Patients With Neuromodulated Syncope Refractory to Medical Treatment: Randomized Double-blind Clinical Trial	Completed	NCT03876652

Search NIH Clinical Center for Syncope

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Genetic Tests for Syncope

Genetic tests related to Syncope:

#	Genetic test	Affiliating Genes
1	Syncope ²⁸

Sources

Anatomical Context for Syncope

Organs/tissues related to Syncope:

MalaCards : Heart, Brain, Skin, Whole Blood, Temporal Lobe, Thyroid, Atrioventricular Node

Sources

Publications for Syncope

Articles related to Syncope:

(show top 50) (show all 17977)

#	Title	Authors	PMID	Year
1	Recurrent syncope in patients with a pacemaker and bradyarrhythmia. ⁶²	Davidsen JM...Lee CJ	36337012	2023
2	Convulsive Syncope From Carotid Sinus Syndrome as a Manifestation of Laryngeal Cancer. ⁶²	Goh Co Ian J...Lee TS	35130751	2023
3	Orthostatic Intolerance and Chiari I Malformation. ⁶²	Petracek LS...Rowe PC	36424063	2023
4	Acute Decompensated Aortic Stenosis: State of the Art Review. ⁶²	Patel KP...Khanji MY	36167225	2023
5	Thyroid Cartilage Compression Causing Bow Hunter's Syndrome. ⁶²	Hong X...Prisman E	35152775	2023
6	Myocardial bridging in adult with hypertrophic cardiomyopathy: Imaging findings with coronary computed tomography angiography. ⁶²	Celenk V...Celenk C	36204398	2022
7	Surgery for adult-form scimitar syndrome presenting with syncope and shortness of breath. ⁶²	Yang HY...Wu SJ	35768299	2022
8	SGLT2-inhibitors reduce the cardiac autonomic neuropathy dysfunction and vaso-vagal syncope recurrence in patients with type 2 diabetes mellitus: the SCAN study. ⁶²	Sardu C...Marfella R	35732222	2022
9	Dural lymphoma misdiagnosed as subdural hematoma following head trauma after an episode of syncope. ⁶²	Thibodeau R...Hahn SS	36238205	2022
10	Red Flags in Syncope: Clues for the Diagnosis of Idiopathic Ventricular Fibrillation. ⁶²	Belhassen B...Tovia-Brodie O	35878689	2022
11	Effects of short-term hypercaloric nutrition on orthostatic tolerance in healthy individuals: a randomized controlled crossover study. ⁶²	De Gioannis R...Jordan J	36195683	2022
12	The Impact of Bedside Cardiac Point-of-Care Ultrasound on the Utilization of Cardiology Subspecialty Resources in a Pediatric Emergency Department. ⁶²	Singh A...Neal AE	36449742	2022
13	Medium-term outcomes of myocarditis and pericarditis following BNT162b2 vaccination among adolescents in Hong Kong. ⁶²	Chua GT...Ip P	36149830	2022
14	Frequency and burden of neurological manifestations upon hospital presentation in COVID-19 patients: Findings from a large Brazilian cohort. ⁶²	Marcolino MS...Teixeira AL	36375382	2022
15	Characteristics, clinical findings and outcomes of acute aortic dissection: A comparison between an Australian emergency department and the International Registry of Acute Aortic Dissection. ⁶²	Slaven J...Middleton PM	35636964	2022
16	Safety of office-based flexible endoscopic procedures of the pharynx and larynx under topical anesthesia. ⁶²	Woisard V...Gallois Y	35916924	2022
17	A Review of Cardiac Amyloidosis: Presentation, Diagnosis, and Treatment. ⁶²	Pour-Ghaz I...Nayyar M	35995246	2022
18	Clinical autonomic nervous system laboratories in Europe: A joint survey of the European Academy of Neurology and the European Federation of Autonomic Societies: A joint survey of the European Academy of Neurology and the European Federation of Autonomic Societies. ⁶²	Habek M...Collaborators of the European Network of Clinical ANS laboratories	36056590	2022
19	Abnormal circadian blood pressure regulation and cognitive impairment in α-synucleinopathies. ⁶²	Tanaka R...Hattori N	36123397	2022
20	Efficacy and safety of blood pricking and cupping for treating nonspecific low back pain: a systematic review and Meta-analysis. ⁶²	Chaoju X...Jinsheng Y	36378043	2022
21	Correction to: Faintly tired: a systematic review of fatigue in patients with orthostatic syncope. ⁶²	Wu REY...Claydon VE	36125584	2022
22	Vasovagal syncope: Treat the patient, and not just the disease. ⁶²	Raj SR...Sheldon RS	36182712	2022
23	A woman with syncope and acidosis. ⁶²	Malik AA...Ali MA	36425646	2022
24	Lifetime prevalence and correlates of syncope in five ancestry groups. The HELIUS study. ⁶²	Brewster LM...van Montfrans GA	36389266	2022
25	[Recurrent syncope of unknown origin after ICD implantation: a case report]. ⁶²	Zhao YK...Li J	36456520	2022
26	Energy metabolism and syncope. ⁶²	Rahmouni K	36326945	2022
27	A 22-year-old woman presenting with syncope and seizure. ⁶²	Wade CI...Braun J	36438647	2022
28	Swallowing-induced Paroxysmal Atrial Tachycardia Causes Weight Loss and Fainting during Mealtime: A Case Report and Literature Review. ⁶²	Hosoe T...Shimizu H	35569981	2022
29	Quality of life and symptoms in patients selected for ablation of ventricular extrasystoles: a prospective study. ⁶²	Timmers L...Jordaens L	34855035	2022
30	Characteristics of Adult Rapid Response Events in a Freestanding Children's Hospital. ⁶²	Chalam JN...Cashen K	36377402	2022
31	Predicting the need for blood transfusion requirement in postpartum hemorrhage. ⁶²	Attali E...Zakar L	34107848	2022
32	Current Evidence Involving WALANT Surgery. ⁶²	Connors KM...Koehler SM	36420465	2022
33	Five waves of COVID-19 pandemic in Italy: results of a national survey evaluating the impact on activities related to arrhythmias, pacing, and electrophysiology promoted by AIAC (Italian Association of Arrhythmology and Cardiac Pacing). ⁶²	Boriani G...for AIAC Ricerca Network Investigators	36352300	2022
34	Retrospective clinical study of mandible fractures. ⁶²	Cha S...Ohe J	36322224	2022
35	Hypertensive Conditions: Essential (Primary) Hypertension in Adults. ⁶²	Smith DK...Kipnis CM	36374633	2022
36	Intensive Versus Standard Blood Pressure Lowering and Days Free of Cardiovascular Events and Serious Adverse Events: a Post Hoc Analysis of Systolic Blood Pressure Intervention Trial. ⁶²	Kim DH...Wei LJ	35945470	2022
37	Drug-related bradycardia precipitating hospital admission in older adults: an ongoing problem. ⁶²	Griffiths C...Missouris CG	33627477	2022
38	Characteristics of chest pain in COVID-19 patients in the emergency department. ⁶²	Sinkeldam M...de Vos AM	36269453	2022
39	Safety of 9-valent human papillomavirus vaccine administered to males and females in routine use. ⁶²	Hansen J...Klein NP	36396513	2022
40	Psycho-socio-clinical profiles and quality of life in seizure disorders: A cross-sectional registry study. ⁶²	Kastell SU...Berger J	36179607	2022
41	Anomalous origin of the left coronary artery from the opposite sinus with an interarterial course causing syncope: A case report. ⁶²	Gu H...Xie M	36435622	2022
42	Vasovagal Syncope during Office Hysteroscopy-A Frequently Overlooked Unpleasant Complication. ⁶²	Rodriguez S...Carugno J	36422165	2022
43	Improved health-related quality of life after cardioneuroablation in patients with vasovagal syncope. ⁶²	Baysal E...Aksu T	36357697	2022
44	A Case of a Man with Syncope After Physical Exertion. ⁶²	Kupchik N...Green J	36261906	2022
45	Exercise-induced syncope: A real red flag! ⁶²	Dores H	36442585	2022
46	[CT scan in syncope : diagnostic yield and prescription habits]. ⁶²	Moise M...Cousin F	36354227	2022
47	Palpitations, Dizziness, and Syncope in Teenage Girls: Practical Approach of a Pediatric Cardiologist. ⁶²	Johnsrude CL	36343182	2022
48	Economic evaluation of applying the Canadian Syncope Risk Score in an Australian emergency department. ⁶²	Brain D...Chan J	36403945	2022
49	Low incidence of arrhythmic syncope and pacemaker implantation in older patients with bifascicular block and implantable cardiac monitor. ⁶²	Fumagalli C...Sardu C	36332751	2022
50	Syncope after a long-haul flight revealing multiple embolic events: the management strategy dilemma. ⁶²	Eugenie R...Frederic L	36342108	2022

Sources

Genes for Syncope

Genes related to Syncope (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	42.51	Likely pathogenic ⁵ GeneCards inferred via : Disorders Publications (show sections)
2	SLC6A2	Solute Carrier Family 6 Member 2	Protein Coding	25.4	GeneCards inferred via : Disorders Publications Summaries (show sections)
3	ACTL6A	Actin Like 6A	Protein Coding	25	Likely pathogenic ⁵
4	KCNH2	Potassium Voltage-Gated Channel Subfamily H Member 2	Protein Coding	17.35	GeneCards inferred via : Disorders Publications (show sections)
5	KCNQ1	Potassium Voltage-Gated Channel Subfamily Q Member 1	Protein Coding	17.14	GeneCards inferred via : Disorders Publications (show sections)
6	DBH	Dopamine Beta-Hydroxylase	Protein Coding	16.14	GeneCards inferred via : Disorders Publications (show sections)
7	NPPA	Natriuretic Peptide A	Protein Coding	15.56	GeneCards inferred via : Disorders Publications (show sections)
8	TNNT2	Troponin T2, Cardiac Type	Protein Coding	15.33	GeneCards inferred via : Disorders Publications (show sections)
9	EDN1	Endothelin 1	Protein Coding	8.24	GeneCards inferred via : Publications (show sections)
10	GNB3	G Protein Subunit Beta 3	Protein Coding	8.23	GeneCards inferred via : Publications (show sections)
11	RYR2	Ryanodine Receptor 2	Protein Coding	8.23	GeneCards inferred via : Disorders (show sections)

Sources

Variations for Syncope

ClinVar genetic disease variations for Syncope:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	SCN5A	NM_000335.5(SCN5A):c.1255C>T (p.Gln419Ter)	SNV	Likely Pathogenic	374130	rs1057518916	GRCh37: 3:38647525-38647525 GRCh38: 3:38606034-38606034
2	ACTL6A	NM_004301.5(ACTL6A):c.1129C>T (p.Arg377Trp)	SNV	Likely Pathogenic	549661	rs868064163	GRCh37: 3:179304340-179304340 GRCh38: 3:179586552-179586552
3	CTNNA3	NM_013266.4:c.1532_1884del	DEL	Uncertain Significance	978102		GRCh37: GRCh38:
4	TTN	NM_133379.5(TTN):c.13364A>G (p.Lys4455Arg)	SNV	Uncertain Significance	47753	rs142304137	GRCh37: 2:179613763-179613763 GRCh38: 2:178749036-178749036
5	RYR2	NM_001035.3(RYR2):c.2026G>A (p.Glu676Lys)	SNV	Uncertain Significance	689574	rs1572596015	GRCh37: 1:237659875-237659875 GRCh38: 1:237496575-237496575
6	DSP	NM_004415.4(DSP):c.1388T>C (p.Leu463Pro)	SNV	Uncertain Significance	870076	rs1758934036	GRCh37: 6:7568791-7568791 GRCh38: 6:7568558-7568558
7	SCN5A	NM_000335.5(SCN5A):c.5150G>A (p.Ser1717Asn)	SNV	Uncertain Significance	977176	rs2061032297	GRCh37: 3:38592710-38592710 GRCh38: 3:38551219-38551219
8	LIPT2, KCNE3	NM_005472.5(KCNE3):c.248G>A (p.Arg83His)	SNV	Uncertain Significance	5541	rs17215437	GRCh37: 11:74168361-74168361 GRCh38: 11:74457316-74457316
9	ACTN2	NM_001103.4(ACTN2):c.1040C>T (p.Thr347Met)	SNV	Uncertain Significance	178985	rs727504590	GRCh37: 1:236902765-236902765 GRCh38: 1:236739465-236739465
10	MEFV	NM_000243.3(MEFV):c.2084A>G (p.Lys695Arg)	SNV	Uncertain Significance	2547	rs104895094	GRCh37: 16:3293403-3293403 GRCh38: 16:3243403-3243403

Sources

Expression for Syncope

Search GEO for disease gene expression data for Syncope.

Sources

Pathways for Syncope

Pathways related to Syncope according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cardiac conduction ⁶⁶ Show member pathways Classical Kir channels ⁶⁶ Ion homeostasis ⁶⁶ Ion transport by P-type ATPases ⁶⁶ Muscle contraction ⁶⁶ Phase 1 - inactivation of fast Na+ channels ⁶⁶ Phase 2 - plateau phase ⁶⁶ Phase 3 - rapid repolarisation ⁶⁶ Phase 4 - resting membrane potential ⁶⁶ Physiological factors ⁶⁶ Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) ⁶⁶ Tandem pore domain halothane-inhibited K+ channel (THIK) ⁶⁶ Tandem pore domain potassium channels ⁶⁶ TWIK related potassium channel (TREK) ⁶⁶ TWIK-related alkaline pH activated K+ channel (TALK) ⁶⁶ TWIK-related spinal cord K+ channel (TRESK) ⁶⁶ TWIK-releated acid-sensitive K+ channel (TASK) ⁶⁶	12.37	TNNT2 SCN5A RYR2 NPPA KCNQ1 KCNH2
2	Dopamine-DARPP32 Feedback onto cAMP Pathway ⁶⁴	11.94	KCNQ1 KCNH2 GNB3
3	Potassium Channels ⁶⁶ Show member pathways Ca2+ activated K+ channels ⁶⁶ HCN channels ⁶⁶ Voltage gated Potassium channels ⁶⁶	11.63	KCNQ1 KCNH2 GNB3
4	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	11.22	SCN5A RYR2 KCNQ1 KCNH2 GNB3
5	Monoamine transport ⁷⁴ Show member pathways Serotonin transporter activity ⁷⁴	11.07	SLC6A2 DBH
6	Antiarrhythmic Pathway, Pharmacodynamics ⁶⁰	11	SCN5A RYR2 KCNQ1 KCNH2
7	Sympathetic Nerve Pathway (Neuroeffector Junction) ⁶⁰	10.73	SLC6A2 DBH
8	Methylphenidate Pathway, Pharmacodynamics ⁶⁰ Show member pathways Dopamine receptors ⁶⁶	10.68	SLC6A2 DBH

Sources

GO Terms for Syncope

Biological processes related to Syncope according to GeneCards Suite gene sharing:

(show all 30)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to xenobiotic stimulus	GO:0071466	9.97	EDN1 KCNH2 KCNQ1
2	monoatomic ion transport	GO:0006811	9.95	SCN5A RYR2 KCNQ1 KCNH2
3	potassium ion homeostasis	GO:0055075	9.94	KCNQ1 KCNH2
4	membrane depolarization	GO:0051899	9.93	SCN5A EDN1
5	vasoconstriction	GO:0042310	9.93	EDN1 DBH
6	regulation of heart rate by cardiac conduction	GO:0086091	9.93	SCN5A KCNQ1 KCNH2
7	cardiac conduction system development	GO:0003161	9.92	SCN5A NPPA
8	membrane depolarization during action potential	GO:0086010	9.92	SCN5A KCNH2
9	response to pain	GO:0048265	9.91	SLC6A2 DBH
10	potassium ion export across plasma membrane	GO:0097623	9.91	KCNH2 KCNQ1
11	positive regulation of potassium ion transmembrane transport	GO:1901381	9.9	KCNH2 KCNQ1
12	membrane repolarization during ventricular cardiac muscle cell action potential	GO:0098915	9.89	KCNQ1 KCNH2
13	regulation of membrane repolarization	GO:0060306	9.88	KCNQ1 KCNH2
14	transmembrane transport	GO:0055085	9.88	SLC6A2 SCN5A RYR2 KCNQ1 KCNH2
15	regulation of ventricular cardiac muscle cell membrane repolarization	GO:0060307	9.88	SCN5A KCNQ1 KCNH2
16	cellular response to epinephrine stimulus	GO:0071872	9.87	RYR2 KCNQ1
17	regulation of blood pressure	GO:0008217	9.87	EDN1 GNB3 KCNQ1 NPPA
18	membrane repolarization during action potential	GO:0086011	9.86	KCNQ1 KCNH2
19	renal sodium ion absorption	GO:0070294	9.85	KCNQ1 EDN1
20	response to muscle stretch	GO:0035994	9.85	RYR2 NPPA EDN1
21	membrane repolarization during cardiac muscle cell action potential	GO:0086013	9.84	KCNQ1 KCNH2
22	atrial cardiac muscle cell action potential	GO:0086014	9.83	SCN5A KCNQ1
23	regulation of heart rate	GO:0002027	9.83	SCN5A RYR2 KCNQ1
24	regulation of monoatomic ion transmembrane transport	GO:0034765	9.81	SCN5A KCNQ1 KCNH2
25	positive regulation of cardiac muscle contraction	GO:0060452	9.81	NPPA KCNQ1
26	membrane repolarization	GO:0086009	9.76	KCNQ1 KCNH2
27	positive regulation of heart rate	GO:0010460	9.76	RYR2 NPPA KCNQ1 EDN1
28	regulation of atrial cardiac muscle cell membrane repolarization	GO:0060372	9.73	SCN5A NPPA KCNQ1
29	ventricular cardiac muscle cell action potential	GO:0086005	9.56	SCN5A RYR2 KCNQ1 KCNH2
30	cardiac muscle contraction	GO:0060048	9.32	TNNT2 SCN5A RYR2 KCNQ1 KCNH2

Molecular functions related to Syncope according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane transporter binding	GO:0044325	9.8	SCN5A RYR2 KCNQ1
2	protein kinase A catalytic subunit binding	GO:0034236	9.67	RYR2 KCNQ1
3	scaffold protein binding	GO:0097110	9.63	SCN5A KCNQ1 KCNH2
4	voltage-gated monoatomic ion channel activity	GO:0005244	9.62	SCN5A KCNQ1 KCNH2
5	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	GO:1902282	9.56	KCNQ1 KCNH2
6	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	GO:0086008	9.26	KCNQ1 KCNH2
7	monoatomic ion channel activity	GO:0005216	8.92	SCN5A RYR2 KCNQ1 KCNH2