MCID: SYN036
MIFTS: 46

Syncope

Categories: Neuronal diseases
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Aliases & Classifications for Syncope

MalaCards integrated aliases for Syncope:

Name: Syncope 52 75 28 5 75

Classifications:



External Ids:

ICD11 33 177994271

Summaries for Syncope

NINDS: 52 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or “passing out.” If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may “white out” or “black out.”  The skin may be cold and clammy.  The person drops to the floor as he or she loses consciousness.  After fainting, an individual may be unconscious for a minute or two, but will revive and slowly return to normal.  Syncope can occur in otherwise healthy people and affects all age groups, but occurs more often in the elderly.  There are several types of syncope.  Vasovagal syncope usually has an easily identified triggering event such as emotional stress, trauma, pain, the sight of blood, or prolonged standing.  Carotid sinus syncope happens because of constriction of the carotid artery in the neck and can occur after turning the head, while shaving, or when wearing a tight collar.  Situational syncope happens during urination, defecation, coughing, or as a result of gastrointestinal stimulation.  Syncope can also be a symptom of heart disease or abnormalities that create an uneven heart rate or rhythm that temporarily affect blood volume and its distribution in the body.  Syncope isn’t normally a primary sign of a neurological disorder, but it may indicate an increased risk for neurologic disorders such as Parkinson’s disease, postural orthostatic tachycardia syndrome (POTS), diabetic neuropathy, and other types of neuropathy.  Certain classes of drugs are associated with an increased risk of syncope, including diuretics, calcium antagonists, ACE inhibitors, nitrates, antipsychotics, antihistamines, levodopa, narcotics, and alcohol.

MalaCards based summary: Syncope is related to second-degree atrioventricular block and first-degree atrioventricular block. An important gene associated with Syncope is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Cardiac conduction and Dopamine-DARPP32 Feedback onto cAMP Pathway. The drugs Propranolol and Midodrine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and skin, and related phenotypes are nervous system and normal

Wikipedia: 75 Syncope, commonly known as fainting, or passing out, is a loss of consciousness and muscle strength... more...

Related Diseases for Syncope

Diseases related to Syncope via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 second-degree atrioventricular block 10.2 SCN5A KCNH2
2 first-degree atrioventricular block 10.2 SCN5A KCNH2
3 familial short qt syndrome 10.2 KCNQ1 KCNH2
4 progressive familial heart block 10.2 SCN5A KCNQ1
5 diamond-blackfan anemia 3 10.2 SCN5A KCNH2
6 trichothiodystrophy 7, nonphotosensitive 10.2 SCN5A KCNH2
7 cardiomyopathy, dilated, with woolly hair and keratoderma 10.1 SCN5A RYR2
8 atrial standstill 1 10.1 SCN5A EDN1
9 familial long qt syndrome 10.1 SCN5A KCNQ1 KCNH2
10 anhidrosis, isolated, with normal sweat glands 10.1 RYR2 EDN1
11 long qt syndrome 6 10.1 SCN5A KCNQ1 KCNH2
12 long qt syndrome 14 10.1 SCN5A KCNQ1 KCNH2
13 long qt syndrome 12 10.1 SCN5A KCNQ1 KCNH2
14 brugada syndrome 4 10.1 SCN5A KCNQ1 KCNH2
15 long qt syndrome 13 10.1 SCN5A KCNQ1 KCNH2
16 long qt syndrome 5 10.1 SCN5A KCNQ1 KCNH2
17 developmental and epileptic encephalopathy 14 10.1 SCN5A KCNQ1 KCNH2
18 naxos disease 10.1 SCN5A RYR2
19 atrial standstill 10.1 SCN5A NPPA
20 dopamine beta-hydroxylase deficiency 10.1 SLC6A2 DBH
21 palmoplantar keratoderma, nonepidermolytic 10.1 SCN5A RYR2
22 oppositional defiant disorder 10.0 SLC6A2 DBH
23 brugada syndrome 1 10.0 SCN5A RYR2 KCNH2
24 cardiac conduction defect 10.0 SCN5A RYR2 KCNQ1
25 mitral valve stenosis 10.0 NPPA EDN1
26 renovascular hypertension 10.0 NPPA EDN1
27 progressive familial heart block, type ii 10.0 TNNT2 SCN5A
28 renal hypertension 10.0 EDN1 DBH
29 cocaine abuse 10.0 SLC6A2 DBH
30 hepatorenal syndrome 9.9 NPPA EDN1
31 cardiomyopathy, dilated, 1b 9.9 TNNT2 SCN5A
32 diastolic heart failure 9.9 TNNT2 EDN1
33 coronary artery vasospasm 9.9 TNNT2 EDN1
34 myocardial stunning 9.9 TNNT2 EDN1
35 systolic heart failure 9.9 TNNT2 EDN1
36 sinoatrial node disease 9.9 SCN5A RYR2 KCNQ1 KCNH2
37 long qt syndrome 9 9.9 SCN5A RYR2 KCNQ1 KCNH2
38 short qt syndrome 9.9 SCN5A RYR2 KCNQ1 KCNH2
39 long qt syndrome 3 9.9 SCN5A RYR2 KCNQ1 KCNH2
40 timothy syndrome 9.9 SCN5A RYR2 KCNQ1 KCNH2
41 tricuspid valve insufficiency 9.9 TNNT2 EDN1
42 andersen cardiodysrhythmic periodic paralysis 9.9 SCN5A RYR2 KCNQ1 KCNH2
43 cardiac arrhythmia, ankyrin-b-related 9.9 SCN5A RYR2 KCNQ1 KCNH2
44 jervell and lange-nielsen syndrome 1 9.9 SCN5A RYR2 KCNQ1 KCNH2
45 cardiomyopathy, dilated, 1dd 9.9 TNNT2 RYR2
46 third-degree atrioventricular block 9.9 SCN5A RYR2 KCNQ1 KCNH2
47 long qt syndrome 2 9.9 SCN5A RYR2 KCNQ1 KCNH2
48 nonobstructive coronary artery disease 9.9 TNNT2 EDN1
49 mood disorder 9.9 SLC6A2 GNB3 DBH
50 tricuspid valve disease 9.9 TNNT2 EDN1

Graphical network of the top 20 diseases related to Syncope:



Diseases related to Syncope

Symptoms & Phenotypes for Syncope

MGI Mouse Phenotypes related to Syncope:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.86 DBH EDN1 GNB3 KCNQ1 RYR2 SCN5A
2 normal MP:0002873 9.8 DBH EDN1 KCNQ1 RYR2 SCN5A TNNT2
3 muscle MP:0005369 9.7 EDN1 KCNH2 KCNQ1 NPPA RYR2 SCN5A
4 cardiovascular system MP:0005385 9.61 DBH EDN1 KCNH2 KCNQ1 NPPA RYR2
5 mortality/aging MP:0010768 9.28 ACTL6A DBH EDN1 GNB3 KCNH2 RYR2

Drugs & Therapeutics for Syncope

Drugs for Syncope (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational Phase 4 318-98-9, 525-66-6 62882 4946
2
Midodrine Approved Phase 4 133163-28-7, 42794-76-3 4195
3
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
4 Vasodilator Agents Phase 4
5 Neurotransmitter Agents Phase 4
6 Adrenergic alpha-Agonists Phase 4
7 Adrenergic Agonists Phase 4
8 Vasoconstrictor Agents Phase 4
9 Sympathomimetics Phase 4
10 Antihypertensive Agents Phase 4
11 Anti-Arrhythmia Agents Phase 4
12 Adrenergic beta-Antagonists Phase 4
13 Adrenergic beta-1 Receptor Antagonists Phase 4
14 Adrenergic Antagonists Phase 4
15 Sympatholytics Phase 4
16
Levodopa Approved Phase 3 59-92-7, 63-84-3 6047
17
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
18
Cephalexin Approved, Investigational, Vet_approved Phase 3 15686-71-2 27447
19
Bacitracin Approved, Vet_approved Phase 3 1405-87-4 10909430
20
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
21
Polymyxin B Approved, Vet_approved Phase 3 1405-20-5, 1404-26-8 4868
22
Ofloxacin Approved Phase 3 82419-36-1 4583
23
Clindamycin Approved, Vet_approved Phase 3 18323-44-9, 24729-96-2 29029
24
Fludrocortisone Approved, Investigational Phase 3 127-31-1 31378
25
Atomoxetine Approved Phase 3 82248-59-7, 83015-26-3 54841
26 Antiparkinson Agents Phase 3
27 Dihydroxyphenylalanine Phase 3
28 Dopamine Agents Phase 3
29 Antipsychotic Agents Phase 3
30 Psychotropic Drugs Phase 3
31 Antidepressive Agents Phase 3
32 diuretics Phase 3
33 Antibiotics, Antitubercular Phase 3
34 Anti-Bacterial Agents Phase 3
35 Anti-Infective Agents Phase 3
36 Polymyxins Phase 3
37 Anti-Infective Agents, Local Phase 3
38 Cytochrome P-450 Enzyme Inhibitors Phase 3
39
Clindamycin phosphate Phase 3 32603
40 Clindamycin palmitate Phase 3
41 Anti-Inflammatory Agents Phase 3
42
Norepinephrine Approved Phase 2 51-41-2 439260
43
Acarbose Approved, Investigational Phase 2 56180-94-0 441184 444254
44
Caffeine Approved Phase 2 58-08-2 2519
45
Capsaicin Approved Phase 2 404-86-4 1548943
46
Droxidopa Approved, Investigational Phase 2 23651-95-8 443940 92974
47 Hypoglycemic Agents Phase 2
48 Cardiac Glycosides Phase 2
49 Glycoside Hydrolase Inhibitors Phase 2
50 Central Nervous System Stimulants Phase 2

Interventional clinical trials:

(show top 50) (show all 184)
# Name Status NCT ID Phase Drugs
1 Closed Loop Stimulation for Neuromediated Syncope Unknown status NCT01621464 Phase 4
2 A Randomized Clinical Trial of Fludrocortisone for Vasovagal Syncope: The Second Prevention of Syncope Trial (POST II) Completed NCT00118482 Phase 4 fludrocortisone acetate
3 ISSUE3: International Study on Syncope of Uncertain Etiology 3 Pacemaker Therapy for Patients With Asystolic Neurally-mediated Syncope Completed NCT00359203 Phase 4
4 Propranolol for Syncope With Sympathoadrenal Imbalance Completed NCT00060866 Phase 4 Propranolol
5 Early Loop-Recorder in Suspected Arrhythmogenic Syncope Completed NCT00170261 Phase 4
6 Syncope: Pacing or Recording in the Later Years (SPRITELY) Completed NCT01423994 Phase 4
7 Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV (Post 4) Active, not recruiting NCT01456481 Phase 4 midodrine hydrochloride;matching placebo
8 Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Active, not recruiting NCT02123056 Phase 4 Metoprolol;Matching Placebo
9 Randomized Controlled Trial on Discontinuation of Vasoactive Drugs in Patients With Hypotensive Reflex Syncope Completed NCT02137278 Phase 3 Vasoactive drug therapies
10 Randomized Noninferiority Study of an Antibacterial Envelope Alone Versus Envelope Plus Intraoperative Antibacterial Irrigant and Postoperative Antibiotics to Prevent Cardiac Implantable Electronic Device Infections in High-Risk Patients Completed NCT02809131 Phase 3 polymixin/bacitracin;cephalexin, or levofloxacin, or clindamycin;Saline
11 Comparison of Outcomes With Midodrine and Fludrocortisone for Objective Recurrence in Treating Syncope (COMFORTS Trial) Recruiting NCT04595942 Phase 3 Midodrine Hydrochloride Tablets;Fludrocortisone Acetate Tablets
12 A Randomized, Prospective, Placebo-Controlled, Crossover Study of Atomoxetine in the Prevention of Vasovagal Syncope (POST7) Recruiting NCT05159687 Phase 3 Atomoxetine Hydrochloride;Placebo
13 Benefit of Controlled Rehydration in Unexplained Syncope Terminated NCT00143754 Phase 3
14 A Proof of Principle Study of Atomoxetine for the Prevention of Vasovagal Syncope (VVS): POST6 Completed NCT02500732 Phase 2 Atomoxetine;Placebo
15 Preventing Adverse Reactions in Novice Blood Donors Completed NCT00302900 Phase 2
16 Non-Pharmacologic Therapy for Neurocardiogenic Syncope Completed NCT00096902 Phase 2
17 Propranolol for Syncope With Sympathoadrenal Imbalance in Children Completed NCT00093860 Phase 2 Propranolol
18 Acarbose and Older Adults With Postprandial Hypotension Completed NCT01914133 Phase 2 Acarbose;Placebo
19 The Effect of Capsaicin-Phenylephrine-Caffeine Formulation on Aborting Tilt Induced Syncope in Patients With a History of Vasovagal Syncope Recruiting NCT04972123 Phase 2 CPC - Capsaicin, Phenylephrine, Caffeine;Placebo
20 Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Active, not recruiting NCT02558972 Phase 2 Northera (Droxidopa);Placebo
21 ELectrophysiological Mechanisms Underlying the Inhibitory CArdiac Syncope: Therapeutic and Prognostic Implications The ELICA Study Completed NCT02861274 Phase 1
22 Reducing Orthostatic Intolerance With Oral Rehydration in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Active, not recruiting NCT02854683 Phase 1 Normal Saline
23 EXercise for the Prevention of Syncope Evaluation Suspended NCT00203593 Phase 1
24 Optimizing Diagnostics And Therapy Of Arrhythmia And Syncope Events Using Intelligent Telemetric Solutions. Diagnostics Of Syncope In Children. Unknown status NCT01265290
25 Evaluation of a Mobile Cardiac Outpatient Telemetry System (CardioNet) Versus Standard Loop Event Monitor: A Multi-Center Randomized Study Unknown status NCT00295204
26 Effect of Dietary Salt Supplemantation in Vasovagal Syncope Prophylaxis: A Clinical Trial Unknown status NCT00465946
27 Management of Sleep Apnoea Syndrome (SAS) in Patients With Vasovagal Syncope (VVS): a Protocol for the VVS-SAS Registry Study Unknown status NCT04294524
28 Respiration and Applied Tension Strategies to Reduce Vasovagal Reactions to Blood Donation Unknown status NCT03159156
29 The Iliac Arterio-venous Fistula for Treatment of Neurally Mediated Syncope Study Unknown status NCT02388087
30 Risk of Syncopal Relapses in Patients Treated With Permanent Pacing for Bradyarrhythmic Syncope Unknown status NCT04229589
31 Assessing the Risk of Pulmonary Embolism in Patients After Hospitalization for First Episode of Syncope Unknown status NCT03034525
32 Bradycardia High Risk Patient Identification After Syncope With Loop Recorder an Observational Study in Nancy University Hospital Unknown status NCT04200014
33 Eastbourne Syncope Assessment Study II Unknown status NCT00517023
34 Hypersensitive Troponin Performance to Identify Syncope at Risk of Serious Adverse Events in the Short Term Unknown status NCT03528161
35 OPTIMIZING DIAGNOSTICS AND THERAPY OF ARRHYTHMIA AND SYNCOPE EVENTS USING INTELLIGENT TELEMETRIC SOLUTIONS - Evaluation of Arrhythmia Treatment Efficacy Unknown status NCT01265303
36 Optimizing Diagnostics And Therapy Of Arrhythmia And Syncope Events Using Intelligent Telemetric Solutions. Diagnostics Of Arrhythmia In Children Unknown status NCT01265771
37 OPTIMIZING DIAGNOSTICS AND THERAPY OF ARRHYTHMIA AND SYNCOPE EVENTS USING INTELLIGENT TELEMETRIC SOLUTIONS - Evaluation of Arrhythmia Diagnostics in Adults Unknown status NCT01265758
38 Serum Lactate in Convulsive Syncopes Compared to Non-convulsive Syncopes Unknown status NCT03062683
39 EPIcardial and Endocardial Mapping and Ablation Using Contact Force Catheter in Chagasic Patients With Sustained Ventricular Tachycardia Unknown status NCT01847378
40 Registry Of Acute meDical Emergencies in Brazil - ROAD-Brazil Unknown status NCT02753023
41 Comparison of a Sternal ECG Patch With a Standard Recording System for Holter Monitoring Unknown status NCT02126631
42 REVEAL for Respiration Detection Unknown status NCT01956578
43 Observational Study of the Sleuth Implantable ECG Monitoring System Unknown status NCT00717106
44 Comparison of Continuous Sternal ECG Patch Monitors (Carnation and Zio) Trial Unknown status NCT02031484
45 Evaluation of a New Cardiac Pacemaker Unknown status NCT01700244
46 Pilot Clinical Study of the Sleuth Implantable ECG Monitoring System Unknown status NCT00719277
47 A Survey of Hospitalizations in Cardiology Units in Sub-Saharan Africa Unknown status NCT03231449
48 NICE Guideline 'Red Flags' to Predict Serious Outcome After Transient Loss of Consciousness: Prospective Validation Study in the Emergency Department. Unknown status NCT01498471
49 CardioneuROablation for Reflex Syncope: Effects on autonoMic cArdiac Regulation and Efficacy Assessment - the Roman Syncope Study. Completed NCT03903744
50 Effect of Pacemaker With Closed Loop Sensor on Quality of Life and Recurrence of Syncope in Patients With Neuromodulated Syncope Refractory to Medical Treatment: Randomized Double-blind Clinical Trial Completed NCT03876652

Search NIH Clinical Center for Syncope

Genetic Tests for Syncope

Genetic tests related to Syncope:

# Genetic test Affiliating Genes
1 Syncope 28

Anatomical Context for Syncope

Organs/tissues related to Syncope:

MalaCards : Heart, Brain, Skin, Whole Blood, Temporal Lobe, Thyroid, Atrioventricular Node

Publications for Syncope

Articles related to Syncope:

(show top 50) (show all 17977)
# Title Authors PMID Year
1
Recurrent syncope in patients with a pacemaker and bradyarrhythmia. 62
36337012 2023
2
Convulsive Syncope From Carotid Sinus Syndrome as a Manifestation of Laryngeal Cancer. 62
35130751 2023
3
Orthostatic Intolerance and Chiari I Malformation. 62
36424063 2023
4
Acute Decompensated Aortic Stenosis: State of the Art Review. 62
36167225 2023
5
Thyroid Cartilage Compression Causing Bow Hunter's Syndrome. 62
35152775 2023
6
Myocardial bridging in adult with hypertrophic cardiomyopathy: Imaging findings with coronary computed tomography angiography. 62
36204398 2022
7
Surgery for adult-form scimitar syndrome presenting with syncope and shortness of breath. 62
35768299 2022
8
SGLT2-inhibitors reduce the cardiac autonomic neuropathy dysfunction and vaso-vagal syncope recurrence in patients with type 2 diabetes mellitus: the SCAN study. 62
35732222 2022
9
Dural lymphoma misdiagnosed as subdural hematoma following head trauma after an episode of syncope. 62
36238205 2022
10
Red Flags in Syncope: Clues for the Diagnosis of Idiopathic Ventricular Fibrillation. 62
35878689 2022
11
Effects of short-term hypercaloric nutrition on orthostatic tolerance in healthy individuals: a randomized controlled crossover study. 62
36195683 2022
12
The Impact of Bedside Cardiac Point-of-Care Ultrasound on the Utilization of Cardiology Subspecialty Resources in a Pediatric Emergency Department. 62
36449742 2022
13
Medium-term outcomes of myocarditis and pericarditis following BNT162b2 vaccination among adolescents in Hong Kong. 62
36149830 2022
14
Frequency and burden of neurological manifestations upon hospital presentation in COVID-19 patients: Findings from a large Brazilian cohort. 62
36375382 2022
15
Characteristics, clinical findings and outcomes of acute aortic dissection: A comparison between an Australian emergency department and the International Registry of Acute Aortic Dissection. 62
35636964 2022
16
Safety of office-based flexible endoscopic procedures of the pharynx and larynx under topical anesthesia. 62
35916924 2022
17
A Review of Cardiac Amyloidosis: Presentation, Diagnosis, and Treatment. 62
35995246 2022
18
Clinical autonomic nervous system laboratories in Europe: A joint survey of the European Academy of Neurology and the European Federation of Autonomic Societies: A joint survey of the European Academy of Neurology and the European Federation of Autonomic Societies. 62
36056590 2022
19
Abnormal circadian blood pressure regulation and cognitive impairment in α-synucleinopathies. 62
36123397 2022
20
Efficacy and safety of blood pricking and cupping for treating nonspecific low back pain: a systematic review and Meta-analysis. 62
36378043 2022
21
Correction to: Faintly tired: a systematic review of fatigue in patients with orthostatic syncope. 62
36125584 2022
22
Vasovagal syncope: Treat the patient, and not just the disease. 62
36182712 2022
23
A woman with syncope and acidosis. 62
36425646 2022
24
Lifetime prevalence and correlates of syncope in five ancestry groups. The HELIUS study. 62
36389266 2022
25
[Recurrent syncope of unknown origin after ICD implantation: a case report]. 62
36456520 2022
26
Energy metabolism and syncope. 62
36326945 2022
27
A 22-year-old woman presenting with syncope and seizure. 62
36438647 2022
28
Swallowing-induced Paroxysmal Atrial Tachycardia Causes Weight Loss and Fainting during Mealtime: A Case Report and Literature Review. 62
35569981 2022
29
Quality of life and symptoms in patients selected for ablation of ventricular extrasystoles: a prospective study. 62
34855035 2022
30
Characteristics of Adult Rapid Response Events in a Freestanding Children's Hospital. 62
36377402 2022
31
Predicting the need for blood transfusion requirement in postpartum hemorrhage. 62
34107848 2022
32
Current Evidence Involving WALANT Surgery. 62
36420465 2022
33
Five waves of COVID-19 pandemic in Italy: results of a national survey evaluating the impact on activities related to arrhythmias, pacing, and electrophysiology promoted by AIAC (Italian Association of Arrhythmology and Cardiac Pacing). 62
36352300 2022
34
Retrospective clinical study of mandible fractures. 62
36322224 2022
35
Hypertensive Conditions: Essential (Primary) Hypertension in Adults. 62
36374633 2022
36
Intensive Versus Standard Blood Pressure Lowering and Days Free of Cardiovascular Events and Serious Adverse Events: a Post Hoc Analysis of Systolic Blood Pressure Intervention Trial. 62
35945470 2022
37
Drug-related bradycardia precipitating hospital admission in older adults: an ongoing problem. 62
33627477 2022
38
Characteristics of chest pain in COVID-19 patients in the emergency department. 62
36269453 2022
39
Safety of 9-valent human papillomavirus vaccine administered to males and females in routine use. 62
36396513 2022
40
Psycho-socio-clinical profiles and quality of life in seizure disorders: A cross-sectional registry study. 62
36179607 2022
41
Anomalous origin of the left coronary artery from the opposite sinus with an interarterial course causing syncope: A case report. 62
36435622 2022
42
Vasovagal Syncope during Office Hysteroscopy-A Frequently Overlooked Unpleasant Complication. 62
36422165 2022
43
Improved health-related quality of life after cardioneuroablation in patients with vasovagal syncope. 62
36357697 2022
44
A Case of a Man with Syncope After Physical Exertion. 62
36261906 2022
45
Exercise-induced syncope: A real red flag! 62
36442585 2022
46
[CT scan in syncope : diagnostic yield and prescription habits]. 62
36354227 2022
47
Palpitations, Dizziness, and Syncope in Teenage Girls: Practical Approach of a Pediatric Cardiologist. 62
36343182 2022
48
Economic evaluation of applying the Canadian Syncope Risk Score in an Australian emergency department. 62
36403945 2022
49
Low incidence of arrhythmic syncope and pacemaker implantation in older patients with bifascicular block and implantable cardiac monitor. 62
36332751 2022
50
Syncope after a long-haul flight revealing multiple embolic events: the management strategy dilemma. 62
36342108 2022

Variations for Syncope

ClinVar genetic disease variations for Syncope:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SCN5A NM_000335.5(SCN5A):c.1255C>T (p.Gln419Ter) SNV Likely Pathogenic
374130 rs1057518916 GRCh37: 3:38647525-38647525
GRCh38: 3:38606034-38606034
2 ACTL6A NM_004301.5(ACTL6A):c.1129C>T (p.Arg377Trp) SNV Likely Pathogenic
549661 rs868064163 GRCh37: 3:179304340-179304340
GRCh38: 3:179586552-179586552
3 CTNNA3 NM_013266.4:c.1532_1884del DEL Uncertain Significance
978102 GRCh37:
GRCh38:
4 TTN NM_133379.5(TTN):c.13364A>G (p.Lys4455Arg) SNV Uncertain Significance
47753 rs142304137 GRCh37: 2:179613763-179613763
GRCh38: 2:178749036-178749036
5 RYR2 NM_001035.3(RYR2):c.2026G>A (p.Glu676Lys) SNV Uncertain Significance
689574 rs1572596015 GRCh37: 1:237659875-237659875
GRCh38: 1:237496575-237496575
6 DSP NM_004415.4(DSP):c.1388T>C (p.Leu463Pro) SNV Uncertain Significance
870076 rs1758934036 GRCh37: 6:7568791-7568791
GRCh38: 6:7568558-7568558
7 SCN5A NM_000335.5(SCN5A):c.5150G>A (p.Ser1717Asn) SNV Uncertain Significance
977176 rs2061032297 GRCh37: 3:38592710-38592710
GRCh38: 3:38551219-38551219
8 LIPT2, KCNE3 NM_005472.5(KCNE3):c.248G>A (p.Arg83His) SNV Uncertain Significance
5541 rs17215437 GRCh37: 11:74168361-74168361
GRCh38: 11:74457316-74457316
9 ACTN2 NM_001103.4(ACTN2):c.1040C>T (p.Thr347Met) SNV Uncertain Significance
178985 rs727504590 GRCh37: 1:236902765-236902765
GRCh38: 1:236739465-236739465
10 MEFV NM_000243.3(MEFV):c.2084A>G (p.Lys695Arg) SNV Uncertain Significance
2547 rs104895094 GRCh37: 16:3293403-3293403
GRCh38: 16:3243403-3243403

Expression for Syncope

Search GEO for disease gene expression data for Syncope.

Pathways for Syncope

Pathways related to Syncope according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 TNNT2 SCN5A RYR2 NPPA KCNQ1 KCNH2
2 11.94 KCNQ1 KCNH2 GNB3
3
Show member pathways
11.63 KCNQ1 KCNH2 GNB3
4 11.22 SCN5A RYR2 KCNQ1 KCNH2 GNB3
5
Show member pathways
11.07 SLC6A2 DBH
6 11 SCN5A RYR2 KCNQ1 KCNH2
7 10.73 SLC6A2 DBH
8
Show member pathways
10.68 SLC6A2 DBH

GO Terms for Syncope

Biological processes related to Syncope according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 cellular response to xenobiotic stimulus GO:0071466 9.97 EDN1 KCNH2 KCNQ1
2 monoatomic ion transport GO:0006811 9.95 SCN5A RYR2 KCNQ1 KCNH2
3 potassium ion homeostasis GO:0055075 9.94 KCNQ1 KCNH2
4 membrane depolarization GO:0051899 9.93 SCN5A EDN1
5 vasoconstriction GO:0042310 9.93 EDN1 DBH
6 regulation of heart rate by cardiac conduction GO:0086091 9.93 SCN5A KCNQ1 KCNH2
7 cardiac conduction system development GO:0003161 9.92 SCN5A NPPA
8 membrane depolarization during action potential GO:0086010 9.92 SCN5A KCNH2
9 response to pain GO:0048265 9.91 SLC6A2 DBH
10 potassium ion export across plasma membrane GO:0097623 9.91 KCNH2 KCNQ1
11 positive regulation of potassium ion transmembrane transport GO:1901381 9.9 KCNH2 KCNQ1
12 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.89 KCNQ1 KCNH2
13 regulation of membrane repolarization GO:0060306 9.88 KCNQ1 KCNH2
14 transmembrane transport GO:0055085 9.88 SLC6A2 SCN5A RYR2 KCNQ1 KCNH2
15 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.88 SCN5A KCNQ1 KCNH2
16 cellular response to epinephrine stimulus GO:0071872 9.87 RYR2 KCNQ1
17 regulation of blood pressure GO:0008217 9.87 EDN1 GNB3 KCNQ1 NPPA
18 membrane repolarization during action potential GO:0086011 9.86 KCNQ1 KCNH2
19 renal sodium ion absorption GO:0070294 9.85 KCNQ1 EDN1
20 response to muscle stretch GO:0035994 9.85 RYR2 NPPA EDN1
21 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.84 KCNQ1 KCNH2
22 atrial cardiac muscle cell action potential GO:0086014 9.83 SCN5A KCNQ1
23 regulation of heart rate GO:0002027 9.83 SCN5A RYR2 KCNQ1
24 regulation of monoatomic ion transmembrane transport GO:0034765 9.81 SCN5A KCNQ1 KCNH2
25 positive regulation of cardiac muscle contraction GO:0060452 9.81 NPPA KCNQ1
26 membrane repolarization GO:0086009 9.76 KCNQ1 KCNH2
27 positive regulation of heart rate GO:0010460 9.76 RYR2 NPPA KCNQ1 EDN1
28 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.73 SCN5A NPPA KCNQ1
29 ventricular cardiac muscle cell action potential GO:0086005 9.56 SCN5A RYR2 KCNQ1 KCNH2
30 cardiac muscle contraction GO:0060048 9.32 TNNT2 SCN5A RYR2 KCNQ1 KCNH2

Molecular functions related to Syncope according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transporter binding GO:0044325 9.8 SCN5A RYR2 KCNQ1
2 protein kinase A catalytic subunit binding GO:0034236 9.67 RYR2 KCNQ1
3 scaffold protein binding GO:0097110 9.63 SCN5A KCNQ1 KCNH2
4 voltage-gated monoatomic ion channel activity GO:0005244 9.62 SCN5A KCNQ1 KCNH2
5 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.56 KCNQ1 KCNH2
6 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.26 KCNQ1 KCNH2
7 monoatomic ion channel activity GO:0005216 8.92 SCN5A RYR2 KCNQ1 KCNH2

Sources for Syncope

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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