Aliases & Classifications for Syncope

MalaCards integrated aliases for Syncope:

Name: Syncope 54 29 6 3

Summaries for Syncope

NINDS : 54 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or “passing out.” If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may “white out” or “black out.”  The skin may be cold and clammy.  The person drops to the floor as he or she loses consciousness.  After fainting, an individual may be unconscious for a minute or two, but will revive and slowly return to normal.  Syncope can occur in otherwise healthy people and affects all age groups, but occurs more often in the elderly.  There are several types of syncope.  Vasovagal syncope usually has an easily identified triggering event such as emotional stress, trauma, pain, the sight of blood, or prolonged standing.  Carotid sinus syncope happens because of constriction of the carotid artery in the neck and can occur after turning the head, while shaving, or when wearing a tight collar.  Situational syncope happens during urination, defecation, coughing, or as a result of gastrointestinal stimulation.  Syncope can also be a symptom of heart disease or abnormalities that create an uneven heart rate or rhythm that temporarily affect blood volume and its distribution in the body.  Syncope isn’t normally a primary sign of a neurological disorder, but it may indicate an increased risk for neurologic disorders such as Parkinson’s disease, postural orthostatic tachycardia syndrome (POTS), diabetic neuropathy, and other types of neuropathy.  Certain classes of drugs are associated with an increased risk of syncope, including diuretics, calcium antagonists, ACE inhibitors, nitrates, antipsychotics, antihistamines, levodopa, narcotics, and alcohol.

MalaCards based summary : Syncope is related to jervell and lange-nielsen syndrome 1 and catecholaminergic polymorphic ventricular tachycardia. An important gene associated with Syncope is SLC6A2 (Solute Carrier Family 6 Member 2), and among its related pathways/superpathways are Transmission across Chemical Synapses and Human Embryonic Stem Cell Pluripotency. The drugs Ranolazine and Timolol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related phenotypes are cardiovascular system and muscle

Wikipedia : 76 Syncope, also known as fainting, is a loss of consciousness and muscle strength characterized by a fast... more...

Related Diseases for Syncope

Diseases related to Syncope via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 jervell and lange-nielsen syndrome 1 32.4 KCNH2 KCNQ1 SCN5A
2 catecholaminergic polymorphic ventricular tachycardia 32.3 KCNH2 KCNJ2 SCN5A
3 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 31.8 KCNH2 KCNJ2 KCNQ1 SCN5A
4 long qt syndrome 9 31.5 KCNJ2 SCN5A
5 brugada syndrome 31.5 KCNH2 KCNQ1 SCN5A
6 long qt syndrome 13 31.4 KCNH2 KCNQ1 SCN5A
7 long qt syndrome 12 31.4 KCNH2 KCNQ1 SCN5A
8 long qt syndrome 3 31.4 KCNH2 KCNQ1 SCN5A
9 andersen cardiodysrhythmic periodic paralysis 30.8 KCNH2 KCNJ2 KCNQ1 SCN5A
10 atrial standstill 1 30.6 ACTN2 NPPB SCN5A TTN
11 long qt syndrome 5 30.6 KCNH2 KCNJ2 KCNQ1 SCN5A
12 long qt syndrome 6 30.5 KCNH2 KCNJ2 KCNQ1 SCN5A
13 long qt syndrome 2 30.5 KCNH2 KCNJ2 KCNQ1 SCN5A
14 long qt syndrome 1 30.5 KCNH2 KCNJ2 KCNQ1 SCN5A
15 ventricular fibrillation, paroxysmal familial, 1 30.0 KCNH2 KCNQ1 SCN5A
16 pure autonomic failure 29.9 GNB3 NPPA
17 cardiac conduction defect 29.7 KCNH2 KCNQ1 SCN5A
18 atrioventricular block 29.6 KCNH2 KCNQ1 NPPB SCN5A
19 long qt syndrome 29.3 KCNH2 KCNJ2 KCNQ1 SCN5A
20 cardiac arrhythmia 29.2 KCNH2 KCNJ2 KCNQ1 SCN5A
21 short qt syndrome 29.0 KCNH2 KCNJ2 KCNQ1
22 peripartum cardiomyopathy 28.9 GNB3 SCN5A TTN
23 familial atrial fibrillation 28.9 KCNH2 KCNJ2 KCNQ1 NPPA SCN5A
24 left ventricular noncompaction 28.6 ACTN2 KCNQ1 SCN5A TTN
25 arrhythmogenic right ventricular cardiomyopathy 28.5 ACTN2 KCNH2 SCN5A TTN
26 atrial fibrillation 26.7 KCNH2 KCNJ2 KCNQ1 NPPA NPPB SCN5A
27 heart disease 26.2 KCNH2 KCNJ2 KCNQ1 NPPA NPPB SCN5A
28 syncope, familial vasovagal 12.3
29 ventricular extrasystoles with syncopal episodes - perodactyly - robin sequence 12.1
30 ventricular extrasystoles with syncope, perodactyly, and robin sequence 11.9
31 fainting 11.5
32 ventricular tachycardia, catecholaminergic polymorphic, 2 11.5
33 ventricular tachycardia, catecholaminergic polymorphic, 4 11.5
34 progressive familial heart block, type ia 11.1
35 orthostatic intolerance 11.1
36 wolff-parkinson-white syndrome 11.0
37 postural hypotension 11.0
38 progressive familial heart block, type ib 11.0
39 pulmonary hypertension 11.0
40 sinoatrial node dysfunction and deafness 10.8
41 cardiac arrhythmia, ankyrin-b-related 10.8
42 sick sinus syndrome 1 10.8
43 muscular dystrophy, limb-girdle, type 2x 10.8
44 dementia, lewy body 10.8
45 progressive familial heart block, type ii 10.8
46 long qt syndrome 10 10.8
47 sick sinus syndrome 3 10.8
48 long qt syndrome 11 10.8
49 cardiomyopathy, familial hypertrophic, 6 10.6
50 cardiomyopathy, familial hypertrophic, 11 10.6

Graphical network of the top 20 diseases related to Syncope:



Diseases related to Syncope

Symptoms & Phenotypes for Syncope

MGI Mouse Phenotypes related to Syncope:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 KCNH2 KCNJ2 KCNQ1 NPPA SCN5A SLC6A2
2 muscle MP:0005369 9.1 KCNH2 KCNJ2 KCNQ1 NPPA SCN5A TTN

Drugs & Therapeutics for Syncope

Drugs for Syncope (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 503)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranolazine Approved, Investigational Phase 4,Phase 2 142387-99-3, 95635-55-5 56959
2
Timolol Approved Phase 4,Phase 2,Not Applicable 26839-75-8 33624 5478
3
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
4
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 185243-69-0
5
Propranolol Approved, Investigational Phase 4,Phase 2,Not Applicable 525-66-6 4946
6
Ethanol Approved Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 64-17-5 702
7
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
8
Carvedilol Approved, Investigational Phase 4,Phase 1,Phase 2 72956-09-3 2585
9 Titanium dioxide Approved Phase 4 13463-67-7
10
Petrolatum Approved, Investigational Phase 4,Phase 2 8009-03-8
11
Sertraline Approved Phase 4 79617-96-2 68617
12
Amlodipine Approved Phase 4 88150-42-9 2162
13
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
14
Losartan Approved Phase 4 114798-26-4 3961
15
Midodrine Approved Phase 4,Not Applicable 133163-28-7, 42794-76-3 4195
16
Benzoyl peroxide Approved Phase 4,Phase 3 94-36-0 7187
17
Ephedrine Approved Phase 4,Early Phase 1 299-42-3 9294
18
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Not Applicable 58-93-5 3639
19
Fludrocortisone Approved, Investigational Phase 4 127-31-1 31378
20
Pseudoephedrine Approved Phase 4,Early Phase 1 90-82-4 7028
21
Gliclazide Approved Phase 4,Phase 3 21187-98-4 3475
22
Treprostinil Approved, Investigational Phase 4,Phase 3,Phase 2 81846-19-7 54786 6918140
23
Adapalene Approved Phase 4 106685-40-9 60164
24
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
25
Acitretin Approved Phase 4 55079-83-9 6437841 5284513
26
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
27
Clobetasol Approved, Investigational Phase 4 25122-46-7, 25122-41-2 32798 5311051
28
Bisoprolol Approved Phase 4,Phase 3 66722-44-9 2405
29
Metoprolol Approved, Investigational Phase 4,Phase 3,Not Applicable 37350-58-6, 51384-51-1 4171
30
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
31
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
32
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
33
Clindamycin Approved, Vet_approved Phase 4,Phase 3 18323-44-9 29029
34
Brinzolamide Approved Phase 4 138890-62-7 68844
35
Glyburide Approved Phase 4,Phase 3 10238-21-8 3488
36
Testosterone Approved, Investigational Phase 4 58-22-0 6013
37
Ketoconazole Approved, Investigational Phase 4 65277-42-1 47576 3823
38
Glimepiride Approved Phase 4,Phase 3 93479-97-1 3476
39
Angiotensin II Approved, Investigational Phase 4,Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
40
Droxidopa Approved, Investigational Phase 4,Phase 3,Phase 2 23651-95-8 443940
41
Epoprostenol Approved Phase 4,Phase 3 61849-14-7, 35121-78-9 5280427 5282411
42
Methyltestosterone Approved Phase 4 58-18-4 6010
43
Tavaborole Approved, Investigational Phase 4 174671-46-6
44
Testosterone enanthate Approved Phase 4 315-37-7 9416
45
Atenolol Approved Phase 4 29122-68-7 2249
46
Donepezil Approved Phase 4,Phase 2 120014-06-4 3152
47
Enalaprilat Approved Phase 4 76420-72-9 6917719
48
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
49
Tamsulosin Approved, Investigational Phase 4,Phase 3 106133-20-4 129211
50
Silodosin Approved Phase 4,Phase 3 160970-54-7

Interventional clinical trials:

(show top 50) (show all 524)
# Name Status NCT ID Phase Drugs
1 Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study) Unknown status NCT01621464 Phase 4
2 Safety of Amiodarone and Ranolazine Together in Patients With Angina Unknown status NCT01558830 Phase 4 ranolazine;placebo
3 Mometasone Furoate Cream Reduces Acute Radiation Dermatitis in Head and Neck Squamous Cell Carcinomas' Patients Unknown status NCT02495064 Phase 4 Mometasone Furoate Cream
4 The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding Unknown status NCT02385422 Phase 4 Carvedilol;Propranolol
5 Topical r-Hirudin ( Thrombexx ) Efficacy in Treatment of Haematomas Unknown status NCT01960569 Phase 4 active product ( Thrombexx) assigned to arm 1
6 A Randomized Trial of Angiotensin Receptor bLocker,Fimasartan, in Aortic Stenosis (ALFA Trial) Unknown status NCT01589380 Phase 4 Fimasartan;Placebo
7 Aortic Stenosis and PhosphodiEsterase Type 5 iNhibition (ASPEN): A Pilot Study Unknown status NCT01275339 Phase 4 Tadalafil;Placebo
8 ISSUE3: International Study on Syncope of Uncertain Etiology 3 Completed NCT00359203 Phase 4
9 Clinical Trial for the Prevention of Vasovagal Syncope Completed NCT00118482 Phase 4 fludrocortisone acetate
10 ELIAS: Early Loop-Recorder in Suspected Arrhythmogenic Syncope Completed NCT00170261 Phase 4
11 Propranolol to Treat Fainting Due to Sympathoadrenal Imbalance Completed NCT00060866 Phase 4 Propranolol
12 Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01518946 Phase 4 Midodrine HCl;Placebo
13 Multicenter Automatic Defibrillator Implantation Trial - Reduce Inappropriate Therapy Completed NCT00947310 Phase 4
14 Comparision of Blood Pressure Variability Between Amlodipine and Losartan Completed NCT01964079 Phase 4 Amlodipine;Losartan
15 Study of Sitagliptin Treatment in Patients With Type 2 Diabetes During Ramadan (0431-263) Completed NCT01131182 Phase 4 Sitagliptin phosphate;Comparator: Sulfonylurea;Metformin
16 Physiologic Evaluation of Anomalous Right Coronary Artery Stenosis Completed NCT01133054 Phase 4
17 Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01515865 Phase 4 Midodrine HCl;Placebo
18 Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension Completed NCT00555880 Phase 4 Midodrine hydrochloride;Placebo
19 Ethanol-Free Clobetasol Propionate Foam 0.05% (Olux-E Foam) vs Vehicle Foam in the Treatment of Chronic Hand Dermatitis. Completed NCT01323673 Phase 4 clobetasol propionate 0.05%;Vehicle / Placebo
20 Safety Study of Flector Patch in Children With Minor Soft Tissue Injuries Completed NCT02132247 Phase 4 Diclofenac hydroxyethylpyrrolidine
21 Effects of Testosterone on Myocardial Repolarization Completed NCT03126656 Phase 4 Testosterone Undecanoate
22 Optimal Balloon Catheter Placement During Sonohysterography Completed NCT01936116 Phase 4
23 A Study to Evaluate the Efficacy and Tolerability of Topical Therapies for the Condition of Plaque-Type Psoriasis Completed NCT00852761 Phase 4 Olux-E Foam;Clobex lotion
24 A Comparison of Polyglactin 910 and Chromic Gut Suture in the Closure of Punch Biopsy Sites Completed NCT01722994 Phase 4
25 Postoperative Pain in Single-visit and Multiple-visit Retreatment Cases Completed NCT03042377 Phase 4 Multiple-Visit-"Calcium Hydroxide";Multiple-Visit-"Corticosteroid Paste";Multiple-Visit-"Antibiotic Paste"
26 Safety, Efficacy and Treatment Satisfaction in Patients With PAH Rapidly Switched From Epoprostenol to Remodulin Completed NCT00373360 Phase 4 treprostinil sodium
27 A Study for Patients With Neurogenic Orthostatic Hypotension Completed NCT00046475 Phase 4 Midodrine Hydrochloride
28 Measuring Outcomes In Patients With Pulmonary Arterial Hypertension Not on Active Treatment (MOTION) Completed NCT02191137 Phase 4 Riociguat (Adempas, BAY63-2521)
29 Epoprostenol for Injection in Pulmonary Arterial Hypertension Completed NCT01105091 Phase 4 ACT-385781A (Actelion Epoprostenol);Flolan®
30 Study Evaluating the Efficacy and Safety of Etanercept and Acitretin in Korean Patient With Moderate to Severe Psoriasis Completed NCT00936065 Phase 4 Etanercept;Etanercept + Acitretin;Acitretin
31 Evaluation of the Efficacy and Tolerability of Clobetasol Propionate Foam Compared to Vehicle Foam Completed NCT00842153 Phase 4 Clobetasol propionate foam;Vehicle foam
32 An Open-Label, Prospective Study to Assess the Safety and Effectiveness of Adalimumab in Patients With Moderate to Severe Plaque Psoriasis in the Russian Federation Completed NCT01644396 Phase 4
33 STUDY TO ASSESS THE LONG-TERM SAFETY OF EXTINA (KETOCONAZOLE) FOAM, 2% Completed NCT00703846 Phase 4 Ketoconazole
34 Evaluation of PCLs Using Three EUS-FNA Needles Completed NCT01711294 Phase 4
35 Circadian Ocular Perfusion Pressure and Ocular Blood Flow Completed NCT00800540 Phase 4 Brinzolamide 10 mg/ml/Timolol 5 mg/ml eye drops suspension;Brimonidine 20 mg/ml/Timolol 5 mg/ml eye drops solution
36 A Study Of Sertraline Compared With Paroxetine In The Treatment Of Panic Disorder Completed NCT00677352 Phase 4 sertraline;Paroxetine
37 An Evaluation of the Safety and Pharmacokinetics of Tavaborole Topical Solution for the Treatment of Fungal Disease of the Toenail in Children and Adolescents Completed NCT03405818 Phase 4 Tavaborole 5% Topical Solution
38 DUAC® Early Onset Efficacy Study in Japanese Subjects Completed NCT02557399 Phase 4 Duac® fixed dose combination gel;ADA 0.1% gel;CLDM 1% gel
39 Study Evaluating Etanercept for the Treatment of Moderate to Severe Psoriasis Completed NCT00663052 Phase 4 Etanercept;Etanercept
40 Study of a New Thermo Stable Formulation of Epoprostenol Sodium to Treat Pulmonary Arterial Hypertension (PAH) Completed NCT01462565 Phase 4 current marketed FLOLAN (epoprostenol sodium);new thermo stable formulation of epoprostenol sodium
41 Effects of Etanercept on Nail Psoriasis and Plaque Psoriasis Completed NCT00581100 Phase 4 etanercept
42 Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Recruiting NCT02123056 Phase 4 Metoprolol;Matching Placebo
43 Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV Recruiting NCT01456481 Phase 4 midodrine hydrochloride;matching placebo
44 Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension Recruiting NCT02586623 Phase 4 Droxidopa capsules;Placebo capsules
45 Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia Recruiting NCT03109314 Phase 4 Donepezil
46 Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART) Recruiting NCT03278509 Phase 4 Metoprolol Succinate;Bisoprolol
47 A Study of Crisaborole Ointment 2%; Crisaborole Vehicle; TCS and TCI in Subjects Aged ≥ 2 Years, With Mild-moderate AD Recruiting NCT03539601 Phase 4 Crisaborole ointment, 2%;Hydrocortisone butyrate cream, 0.1%;Pimecrolimus cream, 1%;Crisaborole Vehicle
48 Syncope: Pacing or Recording in the Later Years Active, not recruiting NCT01423994 Phase 4
49 Feasibility Study of the Intensive Systolic Blood Pressure Control Enrolling by invitation NCT02817503 Phase 4 Standard BP control;Moderate BP control;Intensive BP control
50 The Effect of Antihypertensive Medication Timing on Morbidity and Mortality Enrolling by invitation NCT02990663 Phase 4

Search NIH Clinical Center for Syncope

Genetic Tests for Syncope

Genetic tests related to Syncope:

# Genetic test Affiliating Genes
1 Syncope 29

Anatomical Context for Syncope

MalaCards organs/tissues related to Syncope:

41
Heart, Testes, Brain, Skin, Thyroid, Bone, Liver

Publications for Syncope

Articles related to Syncope:

(show top 50) (show all 1012)
# Title Authors Year
1
The Risk of Thirty-Day Serious Dysrhythmia in Elderly Patients With Syncope or Near Syncope. ( 29929650 )
2018
2
Differential diagnosis of unexplained falls in dementia: Results of "Syncope & Dementia" registry. ( 29398249 )
2018
3
A Population-Based Study of Syncope in the Young. ( 29407009 )
2018
4
Pacing for Vasovagal Syncope. ( 29967681 )
2018
5
Prevalence of Pulmonary Embolism in Patients With Syncope. ( 29379959 )
2018
6
Syncope and Headache. ( 29904895 )
2018
7
Pacing in Vasovagal Syncope. ( 29967677 )
2018
8
Hypotensive Drugs and Syncope Due to Orthostatic Hypotension in Older Adults with Dementia (Syncope and Dementia Study). ( 29897099 )
2018
9
AmbulatoryA diagnostic ECG monitoring for syncope and collapse: An assessment of clinical practice in the United States. ( 29314105 )
2018
10
Sympathetic mechanisms in an animal model of vasovagal syncope. ( 29368225 )
2018
11
Syncope caused by complete heart block and ventricular arrhythmia as early manifestation of systemic lupus erythematosus in a pregnant patient: a case report. ( 29954280 )
2018
12
Geographical Differences in Comorbidity Burden and Outcomes in Adults With Syncope Hospitalizations inA Canada. ( 29960620 )
2018
13
Outcomes in syncope research: a systematic review and critical appraisal. ( 29349639 )
2018
14
Does cardiac pacing reduce syncopal recurrences in cardioinhibitory vasovagal syncope patients selected with head-up tilt test? Analysis of a 5-year follow-up database. ( 29980368 )
2018
15
Cor Triatriatum as an Uncommon Cause of Recurrent Syncope. ( 29633128 )
2018
16
Orthostatic blood pressure recovery patterns in suspected syncope in the emergency department. ( 29367218 )
2018
17
Incidence and predictors of syncope recurrence after cardiac pacing in patients with carotid sinus syndrome. ( 29887427 )
2018
18
Emotional orienting during interoceptive threat in orthostatic intolerance: Dysautonomic contributions to psychological symptomatology in the postural tachycardia syndrome and vasovagal syncope. ( 29519640 )
2018
19
Review article: Utility of troponin after syncope: A systematic review and meta-analysis. ( 29873176 )
2018
20
Tilt testing and what you should know about it - Experience with 835 consecutive patients with syncope of unknown origin. ( 29429639 )
2018
21
Usefulness of Tilt Testing and Carotid Sinus Massage for Evaluating Reflex Syncope. ( 29954601 )
2018
22
Diagnostic accuracy of ICD-9 code 780.2 for the identification of patients with syncope in the emergency department. ( 29435866 )
2018
23
TUBB3 E410K syndrome with osteoporosis and cough syncope in a patient previously diagnosed with atypical Moebius syndrome. ( 29289389 )
2018
24
A single-center randomized controlled trial observing the safety and efficacy of modified step-up graded Valsalva manoeuver in patients with vasovagal syncope. ( 29381726 )
2018
25
Pemetrexed-Induced Syncope. ( 29927772 )
2018
26
Implantable loop recorders in patients with unexplained syncope:Clinical predictors of pacemaker implantation. ( 29399750 )
2018
27
Predicting syncope: The first step in a long journey? ( 29883679 )
2018
28
To pace, or not to pace in vasovagal syncope? ( 29970287 )
2018
29
A Rare Cause of Recurrent Cerebral Ischemia and Syncope: Eagle Syndrome. ( 29489579 )
2018
30
Syncope in a middle aged female: Splenic artery aneurysm revisited. ( 29494993 )
2018
31
Treatment of carotid sinus syncope is moving towards personalized medicine. ( 29887437 )
2018
32
Selection of the Best of 2017 on the Usefulness of Cardiac Stimulation in the Treatment of Vasovagal Syncope. ( 29422268 )
2018
33
Evaluation and Management of Patients With Syncope. ( 29872846 )
2018
34
Severe deep venous thromboembolism presenting with syncope associated with airplane travel: Case report and public health quandary. ( 29429796 )
2018
35
Iatrogenic Splenic Laceration Presenting as Syncope. ( 29974002 )
2018
36
A case report of clonidine induced syncope: a review of central actions of an old cardiovascular drug. ( 29433586 )
2018
37
Canine case of swallowing syncope that improved after pacemaker implantation. ( 29398674 )
2018
38
Use of a Pediatric Syncope Unit Improves Diagnosis and Lowers Costs: A Hospital-Based Experience. ( 29961647 )
2018
39
Diagnostic yield of an ambulatory patch monitor in patients with unexplained syncope after initial evaluation in the emergency department: the PATCH-ED study. ( 29921622 )
2018
40
Impact of pharmacological spasm provocation test in patients with a history of syncope. ( 28905210 )
2017
41
Syncope, Junctional Premature Complexes, and Pseudo-Type II Atrioventricular Block. ( 29395000 )
2017
42
The Use of Echocardiography for Pediatric Patients Presenting with Syncope. ( 28888565 )
2017
43
Acute onset autonomic dysfunction and orthostatic syncope as an early manifestation of HIV infection. ( 28856462 )
2017
44
Role of syncope in predicting adverse outcomes in patients with suspected Brugada syndrome undergoing standardized flecainide testing. ( 29309564 )
2017
45
Role of closed loop stimulation pacing (CLS) in vasovagal syncope. ( 28895151 )
2017
46
Giant Left Atrial Myxoma Masquerading as Cough-Syncope Syndrome. ( 28815190 )
2017
47
Role of emergency department observation units in the management of patients with unexplained syncope: a critical review and meta-analysis. ( 29306267 )
2017
48
Prevalence of Pulmonary Embolism in Patients Presenting to the Emergency Department for Syncope. ( 28759507 )
2017
49
Postural Heart Rate Changes in Young Patients With Vasovagal Syncope. ( 28351846 )
2017
50
Prohormones in the Early Diagnosis of Cardiac Syncope. ( 29426039 )
2017

Variations for Syncope

ClinVar genetic disease variations for Syncope:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ACTN2 NM_001103.3(ACTN2): c.1040C> T (p.Thr347Met) single nucleotide variant Conflicting interpretations of pathogenicity rs727504590 GRCh37 Chromosome 1, 236902765: 236902765
2 ACTN2 NM_001103.3(ACTN2): c.1040C> T (p.Thr347Met) single nucleotide variant Conflicting interpretations of pathogenicity rs727504590 GRCh38 Chromosome 1, 236739465: 236739465
3 SCN5A NM_001099404.1(SCN5A): c.1255C> T (p.Gln419Ter) single nucleotide variant Likely pathogenic rs1057518916 GRCh38 Chromosome 3, 38606034: 38606034
4 SCN5A NM_001099404.1(SCN5A): c.1255C> T (p.Gln419Ter) single nucleotide variant Likely pathogenic rs1057518916 GRCh37 Chromosome 3, 38647525: 38647525

Expression for Syncope

Search GEO for disease gene expression data for Syncope.

Pathways for Syncope

Pathways related to Syncope according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 ACTN2 GNB3 KCNH2 KCNJ2 KCNQ1
2
Show member pathways
12.08 GNB3 NPPA NPPB
3 11.98 GNB3 KCNH2 KCNJ2 KCNQ1
4
Show member pathways
11.89 ACTN2 KCNH2 KCNJ2 KCNQ1 NPPA SCN5A
5 11.77 GNB3 KCNH2 KCNQ1 SCN5A
6
Show member pathways
11.63 GNB3 KCNH2 KCNJ2 KCNQ1
7 11 KCNH2 KCNJ2 KCNQ1 SCN5A
8 10.78 NPPA NPPB
9 10.68 KCNJ2 KCNQ1

GO Terms for Syncope

Cellular components related to Syncope according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intercalated disc GO:0014704 9.26 KCNJ2 SCN5A
2 T-tubule GO:0030315 9.16 KCNJ2 SCN5A
3 Z disc GO:0030018 9.13 ACTN2 SCN5A TTN
4 voltage-gated potassium channel complex GO:0008076 8.8 KCNH2 KCNJ2 KCNQ1

Biological processes related to Syncope according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.95 KCNH2 KCNJ2 KCNQ1 SCN5A
2 transmembrane transport GO:0055085 9.95 KCNH2 KCNQ1 SCN5A SLC6A2
3 protein folding GO:0006457 9.81 GNB3 NPPA NPPB
4 regulation of ion transmembrane transport GO:0034765 9.8 KCNH2 KCNJ2 KCNQ1 SCN5A
5 potassium ion transport GO:0006813 9.79 KCNH2 KCNJ2 KCNQ1
6 potassium ion transmembrane transport GO:0071805 9.79 KCNH2 KCNJ2 KCNQ1
7 regulation of blood pressure GO:0008217 9.7 GNB3 NPPA NPPB
8 sarcomere organization GO:0045214 9.66 ACTN2 TTN
9 muscle filament sliding GO:0030049 9.65 ACTN2 TTN
10 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.65 KCNH2 KCNQ1 SCN5A
11 membrane depolarization during action potential GO:0086010 9.64 KCNH2 SCN5A
12 cGMP biosynthetic process GO:0006182 9.63 NPPA NPPB
13 positive regulation of heart rate GO:0010460 9.63 KCNQ1 NPPA
14 positive regulation of potassium ion transmembrane transport GO:1901381 9.63 KCNH2 KCNJ2 KCNQ1
15 regulation of blood vessel size GO:0050880 9.62 NPPA NPPB
16 cardiac conduction GO:0061337 9.62 KCNH2 KCNJ2 KCNQ1 SCN5A
17 cardiac muscle cell action potential involved in contraction GO:0086002 9.61 KCNJ2 SCN5A
18 ventricular cardiac muscle cell action potential GO:0086005 9.61 KCNH2 KCNQ1 SCN5A
19 regulation of cardiac muscle cell contraction GO:0086004 9.6 KCNJ2 SCN5A
20 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.59 KCNJ2 SCN5A
21 positive regulation of cardiac muscle contraction GO:0060452 9.58 KCNQ1 NPPA
22 membrane repolarization GO:0086009 9.58 KCNH2 KCNQ1
23 regulation of membrane repolarization GO:0060306 9.58 KCNH2 KCNJ2 KCNQ1
24 receptor guanylyl cyclase signaling pathway GO:0007168 9.57 NPPA NPPB
25 atrial cardiac muscle cell action potential GO:0086014 9.56 KCNQ1 SCN5A
26 cardiac muscle contraction GO:0060048 9.56 KCNH2 KCNQ1 SCN5A TTN
27 potassium ion export GO:0071435 9.55 KCNH2 KCNQ1
28 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.54 KCNH2 KCNQ1
29 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.54 KCNH2 KCNJ2 KCNQ1
30 potassium ion export across plasma membrane GO:0097623 9.51 KCNH2 KCNQ1
31 membrane repolarization during action potential GO:0086011 9.33 KCNH2 KCNJ2 KCNQ1
32 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.13 KCNQ1 NPPA SCN5A
33 regulation of heart rate by cardiac conduction GO:0086091 8.92 KCNH2 KCNJ2 KCNQ1 SCN5A

Molecular functions related to Syncope according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.63 KCNQ1 SCN5A TTN
2 ion channel binding GO:0044325 9.58 ACTN2 KCNQ1 SCN5A
3 phosphatidylinositol-4,5-bisphosphate binding GO:0005546 9.5 ACTN2 KCNJ2 KCNQ1
4 structural constituent of muscle GO:0008307 9.49 ACTN2 TTN
5 delayed rectifier potassium channel activity GO:0005251 9.48 KCNH2 KCNQ1
6 inward rectifier potassium channel activity GO:0005242 9.43 KCNH2 KCNJ2
7 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.37 KCNH2 KCNQ1
8 scaffold protein binding GO:0097110 9.33 KCNH2 KCNQ1 SCN5A
9 hormone receptor binding GO:0051427 9.26 NPPA NPPB
10 voltage-gated ion channel activity GO:0005244 9.26 KCNH2 KCNJ2 KCNQ1 SCN5A
11 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 8.8 KCNH2 KCNJ2 KCNQ1

Sources for Syncope

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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