VVS
MCID: SYN062
MIFTS: 18

Syncope, Familial Vasovagal (VVS)

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Syncope, Familial Vasovagal

MalaCards integrated aliases for Syncope, Familial Vasovagal:

Name: Syncope, Familial Vasovagal 57
Familial Neurocardiogenic Syncope 20 70
Syncope, Familial Neurocardiogenic 57
Syncope Familial Neurocardiogenic 20
Familial Vasovagal Syncope 20
Vvs 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant

Miscellaneous:
onset in first or second decade
triggers are variable, even within a family


HPO:

31
syncope, familial vasovagal:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 609289
MedGen 41 C1836438
UMLS 70 C1836438

Summaries for Syncope, Familial Vasovagal

OMIM® : 57 Vasovagal syncope (VVS) is an exaggerated tendency toward the common faint caused by a sudden and profound hypotension with or without bradycardia. Several lines of evidence indicate central and peripheral abnormalities of sympathetic function. Newton et al. (2005) stated that a definitive diagnosis of VVS is made only when a patient has reproduction of symptoms in association with hypotension or bradycardia. The head up tilt (HUT) test is the investigation carried out to induce these hemodynamic changes (Parry and Kenny, 1999). This disorder may be the same as Streeten-type orthostatic hypotensive disorder (143850). (609289) (Updated 05-Apr-2021)

MalaCards based summary : Syncope, Familial Vasovagal, also known as familial neurocardiogenic syncope, is related to vulvar vestibulitis syndrome and syncope, and has symptoms including syncope, dizziness and lightheadedness. An important gene associated with Syncope, Familial Vasovagal is VVS (Syncope, Familial Vasovagal). Related phenotypes are vertigo and syncope

Related Diseases for Syncope, Familial Vasovagal

Diseases related to Syncope, Familial Vasovagal via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vulvar vestibulitis syndrome 11.3
2 syncope 10.1
3 migraine with or without aura 1 10.1
4 psychosexual disorder 9.9
5 compartment syndrome 9.9

Graphical network of the top 20 diseases related to Syncope, Familial Vasovagal:



Diseases related to Syncope, Familial Vasovagal

Symptoms & Phenotypes for Syncope, Familial Vasovagal

Human phenotypes related to Syncope, Familial Vasovagal:

31
# Description HPO Frequency HPO Source Accession
1 vertigo 31 HP:0002321
2 syncope 31 HP:0001279

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Neurologic Central Nervous System:
dizziness
lightheadedness
syncope, vasovagal
fainting

Clinical features from OMIM®:

609289 (Updated 05-Apr-2021)

UMLS symptoms related to Syncope, Familial Vasovagal:


syncope; dizziness; lightheadedness

Drugs & Therapeutics for Syncope, Familial Vasovagal

Search Clinical Trials , NIH Clinical Center for Syncope, Familial Vasovagal

Genetic Tests for Syncope, Familial Vasovagal

Anatomical Context for Syncope, Familial Vasovagal

Publications for Syncope, Familial Vasovagal

Articles related to Syncope, Familial Vasovagal:

# Title Authors PMID Year
1
Autosomal dominant vasovagal syncope: clinical features and linkage to chromosome 15q26. 57
23589636 2013
2
Evidence for genetic factors in vasovagal syncope: a twin-family study. 57
22869686 2012
3
Familial neurocardiogenic (vasovagal) syncope. 57
15666305 2005
4
Tilt table testing in the diagnosis of unexplained syncope. 57
10542301 1999
5
Frequency of family history in vasovagal syncope. 57
9800748 1998
6
Syncope in childhood: a case control clinical study of the familial tendency to faint. 57
2207885 1990
7
Genome-Wide Association Study of Copy Number Variations in Patients with Familial Neurocardiogenic Syncope. 61
27156083 2016

Variations for Syncope, Familial Vasovagal

Expression for Syncope, Familial Vasovagal

Search GEO for disease gene expression data for Syncope, Familial Vasovagal.

Pathways for Syncope, Familial Vasovagal

GO Terms for Syncope, Familial Vasovagal

Sources for Syncope, Familial Vasovagal

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....