MCID: SYN062
MIFTS: 20

Syncope, Familial Vasovagal

Categories: Rare diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Syncope, Familial Vasovagal

MalaCards integrated aliases for Syncope, Familial Vasovagal:

Name: Syncope, Familial Vasovagal 57
Familial Neurocardiogenic Syncope 53 73
Syncope, Familial Neurocardiogenic 57
Syncope Familial Neurocardiogenic 53
Familial Vasovagal Syncope 53
Vvs 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
onset in first or second decade
triggers are variable, even within a family


HPO:

32
syncope, familial vasovagal:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Syncope, Familial Vasovagal

OMIM : 57 Vasovagal syncope (VVS) is an exaggerated tendency toward the common faint caused by a sudden and profound hypotension with or without bradycardia. Several lines of evidence indicate central and peripheral abnormalities of sympathetic function. Newton et al. (2005) stated that a definitive diagnosis of VVS is made only when a patient has reproduction of symptoms in association with hypotension or bradycardia. The head up tilt (HUT) test is the investigation carried out to induce these hemodynamic changes (Parry and Kenny, 1999). This disorder may be the same as Streeten-type orthostatic hypotensive disorder (143850). (609289)

MalaCards based summary : Syncope, Familial Vasovagal, also known as familial neurocardiogenic syncope, is related to vulvar vestibulitis syndrome and vaccinia, and has symptoms including dizziness, syncope and lightheadedness. An important gene associated with Syncope, Familial Vasovagal is VVS (Syncope, Familial Vasovagal). Affiliated tissues include testes, and related phenotypes are syncope and vertigo

Related Diseases for Syncope, Familial Vasovagal

Diseases related to Syncope, Familial Vasovagal via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vulvar vestibulitis syndrome 11.7
2 vaccinia 11.3
3 molluscum contagiosum 10.0
4 syncope 10.0
5 lung agenesis 9.9
6 psychosexual disorder 9.9

Graphical network of the top 20 diseases related to Syncope, Familial Vasovagal:



Diseases related to Syncope, Familial Vasovagal

Symptoms & Phenotypes for Syncope, Familial Vasovagal

Symptoms via clinical synopsis from OMIM:

57
Neurologic Central Nervous System:
syncope, vasovagal
fainting
dizziness
lightheadedness


Clinical features from OMIM:

609289

Human phenotypes related to Syncope, Familial Vasovagal:

32
# Description HPO Frequency HPO Source Accession
1 syncope 32 HP:0001279
2 vertigo 32 HP:0002321

UMLS symptoms related to Syncope, Familial Vasovagal:


dizziness, syncope, lightheadedness

Drugs & Therapeutics for Syncope, Familial Vasovagal

Search Clinical Trials , NIH Clinical Center for Syncope, Familial Vasovagal

Genetic Tests for Syncope, Familial Vasovagal

Anatomical Context for Syncope, Familial Vasovagal

MalaCards organs/tissues related to Syncope, Familial Vasovagal:

41
Testes

Publications for Syncope, Familial Vasovagal

Articles related to Syncope, Familial Vasovagal:

# Title Authors Year
1
Genome-Wide Association Study of Copy Number Variations in Patients with Familial Neurocardiogenic Syncope. ( 27156083 )
2016

Variations for Syncope, Familial Vasovagal

Expression for Syncope, Familial Vasovagal

Search GEO for disease gene expression data for Syncope, Familial Vasovagal.

Pathways for Syncope, Familial Vasovagal

GO Terms for Syncope, Familial Vasovagal

Sources for Syncope, Familial Vasovagal

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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