SIADH
MCID: SYN046
MIFTS: 46

Syndrome of Inappropriate Antidiuretic Hormone (SIADH)

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Syndrome of Inappropriate Antidiuretic Hormone

MalaCards integrated aliases for Syndrome of Inappropriate Antidiuretic Hormone:

Name: Syndrome of Inappropriate Antidiuretic Hormone 53
Inappropriate Adh Syndrome 53 73
Dilutional Hyponatremia 53 73
Siadh 53 55
Syndrome of Inappropriate Antidiuretic Hormone Secretion 53
Schwartz Bartter Syndrome 53

Classifications:



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Summaries for Syndrome of Inappropriate Antidiuretic Hormone

NIH Rare Diseases : 53 Syndrome of inappropriate antidiuretic hormone (SIADH) occurs when an excessive amount of antidiuretic hormone is released resulting in water retention and a low sodium level. It is most common among older people. It has many causes including, but not limited too, pain, stress, exercise, a low blood sugar level, certain disorders of the heart, thyroid gland, kidneys, or adrenal glands, and the use of certain medications. Disorders of the lungs and certain cancers may increase the risk of developing SIADH. Treatment includes fluid restriction and sometimes the use of medications that decrease the effect of antidiuretic hormone on the kidneys.

MalaCards based summary : Syndrome of Inappropriate Antidiuretic Hormone, also known as inappropriate adh syndrome, is related to inappropriate adh syndrome and nephrogenic syndrome of inappropriate antidiuresis, and has symptoms including polyuria An important gene associated with Syndrome of Inappropriate Antidiuretic Hormone is AVP (Arginine Vasopressin), and among its related pathways/superpathways are Aquaporin-mediated transport and G alpha (s) signalling events. The drugs Tolvaptan and Empagliflozin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and prostate, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Syndrome of Inappropriate Antidiuretic Hormone

Diseases related to Syndrome of Inappropriate Antidiuretic Hormone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
# Related Disease Score Top Affiliating Genes
1 inappropriate adh syndrome 32.5 AQP2 AVP AVPR2 POMC
2 nephrogenic syndrome of inappropriate antidiuresis 32.2 AVP AVPR2
3 small cell cancer of the lung 30.6 AVP CHGA POMC
4 malignant hypertension 30.3 ACE NPPA
5 lung oat cell carcinoma 30.3 AVP CHGA POMC
6 diabetes insipidus 30.2 AQP2 AVP AVPR2 POMC
7 congestive heart failure 30.1 ACE NPPA NPPB
8 acute myocardial infarction 30.1 ACE NPPA NPPB
9 myocardial infarction 29.9 ACE ALB NPPA NPPB
10 liver cirrhosis 29.7 ALB AQP2 AVP NPPA
11 bartter disease 10.5
12 lung cancer 10.5
13 lymphoma 10.5
14 herpes zoster 10.4
15 squamous cell carcinoma 10.4
16 meningitis 10.4
17 neuroblastoma 10.4
18 olfactory neuroblastoma 10.4
19 prostate cancer 10.3
20 small cell carcinoma 10.3
21 porphyria, acute intermittent 10.2
22 neuromyelitis optica 10.2
23 porphyria 10.2
24 pneumonia 10.2
25 tuberculous meningitis 10.2
26 myxedema 10.2 AVP NPPA
27 cardiac tamponade 10.2 AVP NPPB
28 central sleep apnea 10.2 NPPA NPPB
29 mitral valve stenosis 10.2 NPPA NPPB
30 syncope 10.2 NPPA NPPB
31 benign essential hypertension 10.2 ALB AVP
32 vasculogenic impotence 10.2 ACE NPPA
33 left bundle branch hemiblock 10.2 ACE NPPB
34 constrictive pericarditis 10.2 ALB NPPB
35 central nervous system germinoma 10.2 AVP POMC
36 tuberculous epididymitis 10.2 AVP POMC
37 granulomatous angiitis 10.2 ACE AVP
38 ischemic heart disease 10.2 ACE NPPB
39 central nervous system germ cell tumor 10.2 AVP POMC
40 bronchus cancer 10.2 AVP POMC
41 tricuspid valve insufficiency 10.2 ALB NPPB
42 aortic valve insufficiency 10.2 ACE NPPB
43 secondary hypertrophic osteoarthropathy 10.2 AVP POMC
44 breast cancer 10.2
45 schizophrenia 10.2
46 brain injury 10.2
47 hydrocephalus 10.2
48 aspiration pneumonia 10.2
49 melanoma 10.2
50 adenocarcinoma 10.2

Graphical network of the top 20 diseases related to Syndrome of Inappropriate Antidiuretic Hormone:



Diseases related to Syndrome of Inappropriate Antidiuretic Hormone

Symptoms & Phenotypes for Syndrome of Inappropriate Antidiuretic Hormone

UMLS symptoms related to Syndrome of Inappropriate Antidiuretic Hormone:


polyuria

MGI Mouse Phenotypes related to Syndrome of Inappropriate Antidiuretic Hormone:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 ACE APLN AQP2 AVP AVPR2 POMC
2 homeostasis/metabolism MP:0005376 9.65 ACE ALB APLN AQP2 AVP AVPR2
3 renal/urinary system MP:0005367 9.23 ACE ALB AQP2 AVP AVPR2 CHGA

Drugs & Therapeutics for Syndrome of Inappropriate Antidiuretic Hormone

Drugs for Syndrome of Inappropriate Antidiuretic Hormone (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tolvaptan Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 150683-30-0 216237
2
Empagliflozin Approved Phase 2, Phase 3,Phase 3 864070-44-0
3 Hormones Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
4 Arginine Vasopressin Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
5 Natriuretic Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
6 Vasopressins Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
7 Vasoconstrictor Agents Phase 3,Phase 1,Phase 2
8 arginine Phase 3,Phase 1,Phase 2
9 Hormone Antagonists Phase 3,Phase 1,Phase 2
10 Coagulants Phase 3,Phase 1,Phase 2
11
Satavaptan Phase 3,Phase 2 185913-78-4 7029
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
13 Hemostatics Phase 3,Phase 1,Phase 2
14 Hypoglycemic Agents Phase 2, Phase 3,Phase 3
15 Deamino Arginine Vasopressin Phase 2, Phase 3
16 Pharmaceutical Solutions Phase 2, Phase 3
17
Probenecid Approved, Investigational Phase 1, Phase 2 57-66-9 4911
18
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
19 Antioxidants Phase 1, Phase 2
20 Antiviral Agents Phase 1, Phase 2
21 Anti-Infective Agents Phase 1, Phase 2
22 Expectorants Phase 1, Phase 2
23 N-monoacetylcystine Phase 1, Phase 2
24 Antidotes Phase 1, Phase 2
25 Free Radical Scavengers Phase 1, Phase 2
26 Antirheumatic Agents Phase 1, Phase 2
27 Renal Agents Phase 1, Phase 2
28 Protective Agents Phase 1, Phase 2
29 Respiratory System Agents Phase 1, Phase 2
30 cysteine Phase 1, Phase 2

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-secretion Caused by Treatment With Antiepileptic Medicine Withdrawn NCT00298753 Phase 4
2 Efficacy and Safety Study of the Tolvaptan Tablets in Patients With Non-hypovolemic Non-acute Hyponatremia Unknown status NCT01507727 Phase 2, Phase 3 Tolvaptan;Placebo
3 Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00264914 Phase 3 SR121463B
4 Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00264927 Phase 3 SR121463B
5 Effects of Empagliflozin an SGLT2-Inhibitor on Healthy Volunteers With Induced Hypotonic Hyponatremia - the DIVE Study Completed NCT02729766 Phase 2, Phase 3 Empagliflozin 25mg Tbl;Placebo P-Tablet
6 "SALT-2 Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia Completed NCT00201994 Phase 3 Tolvaptan
7 “SALT Trial” Study of Ascending Levels of Tolvaptan in Hyponatremia Completed NCT00072683 Phase 3 tolvaptan
8 A Multicenter Trial to Investigate the Efficacy and Safety of Tolvaptan in Patients With Hyponatremia in SIADH Recruiting NCT03048747 Phase 3 Tolvaptan Oral Tablet
9 Effects of the SGLT2-inhibitor Empagliflozin on Patients With Chronic SIADH - the SANDx Study Recruiting NCT03202667 Phase 2, Phase 3 Empagliflozin 25mg;Placebo
10 Effects of the SGLT2-inhibitor Empagliflozin on Patients With SIADH - the SAND Study Enrolling by invitation NCT02874807 Phase 2, Phase 3 Empagliflozin
11 A Phase III Study Evaluating the Efficacy and Safety of Satavaptan Versus Placebo in Patients With Dilutional Hyponatremia Terminated NCT00728091 Phase 3 Satavaptan;placebo
12 Effects of Tolvaptan vs Fluid Restriction in Hospitalized Subjects With Dilutional Hyponatremia Terminated NCT01227512 Phase 3 tolvaptan
13 A PK Study of 3 Dosages of Tolvaptan in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Completed NCT02009878 Phase 1, Phase 2 tolvaptan
14 Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00032734 Phase 2 satavaptan (SR121463B)
15 Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After Traumatic Brain Injury Completed NCT01322009 Phase 1, Phase 2 Probenecid and N-acetyl cysteine;Placebo
16 Subclassification of the Syndrome of Inappropriate ADH Secretion Completed NCT01341665
17 An Observational Study on Real-world Use and Outcomes of Patients Treated With Tolvaptan for Hyponatraemia Due to SIADH Completed NCT02545101
18 An Observational Study to Describe the Adherence to the SEOM Algorithm for the Treatment of Hyponatraemia in Spain Completed NCT02548845
19 An Observational Study Measuring Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia in Italy Completed NCT02573077
20 Hyponatremia Registry for Patients With Euvolemic and Hypervolemic Hyponatremia Completed NCT01240668
21 Evaluation of Plasma Volume Using Ultrasound in Disorders of Fluid With Sodium Active, not recruiting NCT01547650
22 Fractional Urate Excretion in Nonedematous Hyponatremia Withdrawn NCT01425125 Not Applicable Tolvaptan in euvolemic hyponatremia

Search NIH Clinical Center for Syndrome of Inappropriate Antidiuretic Hormone

Genetic Tests for Syndrome of Inappropriate Antidiuretic Hormone

Anatomical Context for Syndrome of Inappropriate Antidiuretic Hormone

MalaCards organs/tissues related to Syndrome of Inappropriate Antidiuretic Hormone:

41
Lung, Heart, Prostate, Kidney, Thyroid, Adrenal Gland, Pituitary

Publications for Syndrome of Inappropriate Antidiuretic Hormone

Articles related to Syndrome of Inappropriate Antidiuretic Hormone:

(show top 50) (show all 396)
# Title Authors Year
1
Cisplatin-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH) with life-threatening hyponatraemia. ( 29386213 )
2018
2
Mild water restriction with or without urea for the longterm treatment of syndrome of inappropriate antidiuretic hormone secretion (SIADH): Can urine osmolality help the choice? ( 29017746 )
2018
3
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) ( 29939554 )
2018
4
Safety and Efficacy of Tolvaptan in Korean Patients with Hyponatremia Caused by the Syndrome of Inappropriate Antidiuretic Hormone. ( 29629516 )
2018
5
Successful Treatment of Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Neuro-Sweet Disease in Myelodysplastic Syndrome. ( 29225251 )
2018
6
Successful treatment by tolvaptan of the syndrome of inappropriate antidiuretic hormone secretion that may be associated with chemotherapy-induced tumour lysis in a patient with small-cell lung carcinoma. ( 29796276 )
2018
7
Strongyloides Hyperinfection and Miliary Tuberculosis Presenting with Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Malnourished Patient. ( 29796361 )
2018
8
Antidiuretic hormone- and interleukin-6-producing angioimmunoblastic T-cell lymphoma associated with syndrome of inappropriate antidiuretic hormone secretion. ( 30485406 )
2018
9
Natural killer/T-cell lymphoma with concomitant syndrome of inappropriate antidiuretic hormone secretion: A case report and review of literature. ( 30430128 )
2018
10
Paralytic Ileus and Syndrome of Inappropriate Antidiuretic Hormone Secretion Potentially due to an Interaction Between Vincristine and Voriconazole/Posaconazole. ( 30418228 )
2018
11
Walking hyponatremia syndrome of inappropriate antidiuretic hormone secretion secondary to carbamazepine use: a case report. ( 29991348 )
2018
12
Role of NT-ProBNP to differentiate syndrome of inappropriate antidiuretic hormone secretion and cerebral salt wasting syndrome: The conundrum. ( 30233010 )
2018
13
Corrigendum to "Amiodarone Induced Hyponatremia Masquerading as Syndrome of Inappropriate Antidiuretic Hormone Secretion by Anaplastic Carcinoma of Prostate". ( 30420933 )
2018
14
Syndrome of inappropriate antidiuretic hormone secretion associated with seronegative neuromyelitis optica spectrum disorder. ( 28393003 )
2017
15
Filling the Gap - Improving Awareness and Practice in Hyponatraemia and the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in the Older Patient: A European Consensus View. ( 27701711 )
2017
16
Syndrome of inappropriate antidiuretic hormone secretion induced by the phytotherapy Harpagophytum procumbers: case report. ( 28355406 )
2017
17
Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Amyotrophic Lateral Sclerosis in a Patient Developing Carbon Dioxide Narcosis. ( 28381746 )
2017
18
Syndrome of Inappropriate Antidiuretic Hormone Consecutive to treatment with Ciprofloxacin. ( 28786821 )
2017
19
Neuroendocrine Carcinoma of the Breast With Endobronchial Metastases and Syndrome of Inappropriate Antidiuretic Hormone Secretion. ( 28420584 )
2017
20
A Rare Presentation of the Syndrome of Inappropriate Antidiuretic Hormone in a 12-year old Female as the Initial Presentation of an Immature Ovarian Teratoma. ( 28818586 )
2017
21
Tolvaptan use in cancer patients with hyponatremia due to the syndrome of inappropriate antidiuretic hormone: a post hoc analysis of the SALT-1 and SALT-2 trials. ( 28251822 )
2017
22
Syndrome of inappropriate antidiuretic hormone accompanied by bilateral hypothalamic and anterior thalamic lesions with serum antiaquaporin 4 antibody. ( 28432042 )
2017
23
Bortezomib as a probable cause of the syndrome of inappropriate antidiuretic hormone secretion: A case report and review of the literature. ( 28856001 )
2017
24
Low-dose tolvaptan PK/PD: comparison of patients with hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion to healthy adults. ( 28803333 )
2017
25
Syndrome of Inappropriate Antidiuretic Hormone Secretion Complicating Systemic Nocardiosis in a Renal Transplant Recipient: A Case Report. ( 29198680 )
2017
26
Pure small cell recurrent prostate cancer developing syndrome of inappropriate antidiuretic hormone secretion. ( 28623637 )
2017
27
Morvan syndrome: a rare cause of syndrome of inappropriate antidiuretic hormone secretion. ( 28781533 )
2017
28
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Associated with Mediastinal Schwannoma. ( 29399023 )
2017
29
Syndrome of inappropriate antidiuretic hormone associated with rectal small cell neuroendocrine carcinoma: a case report. ( 28852457 )
2017
30
"Syndrome of Inappropriate Antidiuretic Hormone Secretion" as a Diagnostic and a Prognostic Indicator in Olfactory Neuroblastoma. ( 28670560 )
2017
31
Syndrome of inappropriate antidiuretic hormone secretion following irinotecan-cisplatin administration as a treatment for recurrent ovarian clear cell carcinoma. ( 28217682 )
2017
32
Syndrome of inappropriate antidiuretic hormone secretion in a dog with a histiocytic sarcoma. ( 28698689 )
2017
33
Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Mini-Breed Puppy Associated With Aspiration Pneumonia. ( 29525234 )
2017
34
Effect of single-dose of tolvaptan in neurocritical patients with hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion. ( 28087091 )
2017
35
Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Patient with Mucosa-associated Lymphoid Tissue Lymphoma. ( 29021471 )
2017
36
Recurrent syndrome of inappropriate antidiuretic hormone secretion due to tolterodine in an elderly male patient. ( 28540903 )
2017
37
Hypertrophic Pachymeningitis and the Syndrome of Inappropriate Antidiuretic Hormone Secretion: Coincidence or Cause? ( 28245481 )
2017
38
Syndrome of inappropriate antidiuretic hormone secretion from concomitant use of itraconazole and vindesine. ( 28782144 )
2017
39
Basaloid Squamous Cell Carcinoma of the Lung Associated With Syndrome of Inappropriate Antidiuretic Hormone Secretion. ( 29317964 )
2017
40
Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Liver Transplantation. ( 28238015 )
2017
41
Lack of appropriate investigations in making a diagnosis of syndrome of inappropriate antidiuretic hormone. ( 28260255 )
2017
42
A Case Report of Syndrome of Inappropriate Antidiuretic Hormone Induced by Pregabalin. ( 28275386 )
2016
43
Split Hand Syndrome and Syndrome of Inappropriate Antidiuretic Hormone. ( 26763519 )
2016
44
Diagnosing and Treating the Syndrome of Inappropriate Antidiuretic Hormone Secretion. ( 26584969 )
2016
45
Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Poor Prognosis in Small-cell Lung Cancer. ( 26706100 )
2016
46
Autoimmune Limbic Encephalitis and Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Lamotrigine-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome. ( 27181555 )
2016
47
Morvan's syndrome with anti contactin associated protein like 2 - voltage gated potassium channel antibody presenting with syndrome of inappropriate antidiuretic hormone secretion. ( 27695240 )
2016
48
Development of syndrome of inappropriate antidiuretic hormone secretion (SIADH) after Onyx embolisation of a cavernous carotid fistula. ( 27013230 )
2016
49
Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Associated with Myeloma and Syndrome of Inappropriate Antidiuretic Hormone Secretion in an Elderly Man. ( 27550802 )
2016
50
The syndrome of inappropriate antidiuretic hormone secretion after giant leaf frog (Phyllomedusa bicolor) venom exposure. ( 27421671 )
2016

Variations for Syndrome of Inappropriate Antidiuretic Hormone

Expression for Syndrome of Inappropriate Antidiuretic Hormone

Search GEO for disease gene expression data for Syndrome of Inappropriate Antidiuretic Hormone.

Pathways for Syndrome of Inappropriate Antidiuretic Hormone

GO Terms for Syndrome of Inappropriate Antidiuretic Hormone

Cellular components related to Syndrome of Inappropriate Antidiuretic Hormone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ACE ALB APLN AVP CHGA NPPA
2 secretory granule GO:0030141 9.33 AVP CHGA POMC
3 transport vesicle membrane GO:0030658 9.32 AQP2 CHGA
4 mast cell granule GO:0042629 9.26 CHGA NPPA
5 extracellular space GO:0005615 9.23 ACE ALB APLN AVP CHGA NPPA

Biological processes related to Syndrome of Inappropriate Antidiuretic Hormone according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.72 APLN AVP NPPA NPPB POMC
2 excretion GO:0007588 9.54 AQP2 AVPR2
3 positive regulation of vasoconstriction GO:0045907 9.52 AVP AVPR2
4 positive regulation of blood pressure GO:0045777 9.51 ACE AVPR2
5 regulation of the force of heart contraction GO:0002026 9.49 APLN CHGA
6 water transport GO:0006833 9.48 AQP2 AVP
7 regulation of blood vessel diameter GO:0097746 9.46 ACE NPPB
8 cGMP biosynthetic process GO:0006182 9.43 NPPA NPPB
9 renal water homeostasis GO:0003091 9.43 AQP2 AVP AVPR2
10 positive regulation of cardiac muscle contraction GO:0060452 9.4 CHGA NPPA
11 receptor guanylyl cyclase signaling pathway GO:0007168 9.37 NPPA NPPB
12 regulation of blood vessel size GO:0050880 9.33 AVP NPPA NPPB
13 positive regulation of systemic arterial blood pressure GO:0003084 9.13 ACE AVP AVPR2
14 regulation of blood pressure GO:0008217 9.02 ACE CHGA NPPA NPPB POMC

Molecular functions related to Syndrome of Inappropriate Antidiuretic Hormone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 APLN AVP NPPA NPPB POMC
2 neuropeptide hormone activity GO:0005184 9.26 AVP NPPA
3 hormone receptor binding GO:0051427 9.16 NPPA NPPB
4 hormone activity GO:0005179 9.02 APLN AVP NPPA NPPB POMC

Sources for Syndrome of Inappropriate Antidiuretic Hormone

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