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MCID: SYN046
MIFTS: 28

Syndrome of Inappropriate Antidiuretic Hormone

Categories: Endocrine diseases, Rare diseases
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Aliases & Classifications for Syndrome of Inappropriate Antidiuretic Hormone

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MalaCards integrated aliases for Syndrome of Inappropriate Antidiuretic Hormone:

Name: Syndrome of Inappropriate Antidiuretic Hormone 19 75
Inappropriate Adh Syndrome 71
Dilutional Hyponatremia 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 71 C0021141 C0585109
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Summaries for Syndrome of Inappropriate Antidiuretic Hormone

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MalaCards based summary: Syndrome of Inappropriate Antidiuretic Hormone, also known as inappropriate adh syndrome, is related to inappropriate adh syndrome and nephrogenic syndrome of inappropriate antidiuresis, and has symptoms including polyuria The drugs Empagliflozin and Tolvaptan have been mentioned in the context of this disorder. Affiliated tissues include pituitary, kidney and lung.

Wikipedia: 75 Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is characterized by excessive... more...
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Related Diseases for Syndrome of Inappropriate Antidiuretic Hormone

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Diseases related to Syndrome of Inappropriate Antidiuretic Hormone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 355)
# Related Disease Score Top Affiliating Genes
1 inappropriate adh syndrome 12.0
2 nephrogenic syndrome of inappropriate antidiuresis 11.4
3 posttransplant acute limbic encephalitis 11.4
4 central diabetes insipidus 10.7
5 diabetes insipidus 10.7
6 small cell carcinoma 10.7
7 small cell cancer of the lung 10.6
8 neuroendocrine carcinoma 10.6
9 herpes zoster 10.6
10 paraneoplastic syndromes 10.6
11 hypokalemia 10.6
12 meningitis 10.6
13 antisynthetase syndrome 10.5
14 olfactory neuroblastoma 10.5
15 neuroblastoma 10.5
16 prostate cancer 10.5
17 lung cancer 10.5
18 ocular motor apraxia 10.5
19 porphyria 10.5
20 neuromyelitis optica 10.5
21 esophageal cancer 10.5
22 hydrocephalus 10.5
23 hypothyroidism 10.5
24 neuroendocrine tumor 10.5
25 pneumonia 10.5
26 subacute delirium 10.5
27 chickenpox 10.5
28 diabetes insipidus, neurohypophyseal 10.4
29 porphyria, acute intermittent 10.4
30 lymphoma, hodgkin, classic 10.4
31 myeloma, multiple 10.4
32 congestive heart failure 10.4
33 lung disease 10.4
34 encephalitis 10.4
35 burkitt lymphoma 10.4
36 guillain-barre syndrome, familial 10.4
37 premature ovarian failure 7 10.4
38 lymphoma 10.4
39 limbic encephalitis 10.4
40 meningoencephalitis 10.4
41 guillain-barre syndrome 10.4
42 bronchus cancer 10.4
43 squamous cell carcinoma 10.4
44 churg-strauss syndrome 10.4
45 thymic carcinoma 10.4
46 liver cirrhosis 10.4
47 b-cell lymphoma 10.4
48 vasculitis 10.4
49 hypopituitarism 10.4
50 episodic ataxia 10.4

Graphical network of the top 20 diseases related to Syndrome of Inappropriate Antidiuretic Hormone:



Diseases related to Syndrome of Inappropriate Antidiuretic Hormone
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Symptoms & Phenotypes for Syndrome of Inappropriate Antidiuretic Hormone

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UMLS symptoms related to Syndrome of Inappropriate Antidiuretic Hormone:


polyuria
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Drugs & Therapeutics for Syndrome of Inappropriate Antidiuretic Hormone

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Drugs for Syndrome of Inappropriate Antidiuretic Hormone (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Empagliflozin Approved Phase 2, Phase 3 864070-44-0 73151030 11949646
2
Tolvaptan Approved Phase 3 150683-30-0 216237
3
Satavaptan Investigational Phase 3 185913-78-4 158348
4 Pharmaceutical Solutions Phase 2, Phase 3
5 Sodium-Glucose Transporter 2 Inhibitors Phase 2, Phase 3
6 Hypoglycemic Agents Phase 2, Phase 3
7 Deamino Arginine Vasopressin Phase 2, Phase 3
8 Arginine Vasopressin Phase 3
9 Hormones Phase 3
10 Vasopressins Phase 3
11
Carbamide peroxide Approved Phase 2 124-43-6
12 Tea
13 diuretics

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-secretion Caused by Treatment With Antiepileptic Medicine Withdrawn NCT00298753 Phase 4
2 A Multicenter, Uncontrolled, Open-label, Dose-titration Trial to Investigate the Efficacy and Safety of Tolvaptan Tablets in Patients With Hyponatremia in Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Completed NCT03048747 Phase 3 Tolvaptan Oral Tablet
3 A Randomized, Double-Blind, Placebo-Group, Multicenter Study Evaluating the Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00264927 Phase 3 SR121463B
4 An Open-Label, Multicenter Study Evaluating the Long-Term Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT00264914 Phase 3 SR121463B
5 Effects of Empagliflozin an SGLT2-Inhibitor on Healthy Volunteers With Induced Hypotonic Hyponatremia - the DIVE Study Completed NCT02729766 Phase 2, Phase 3 Empagliflozin 25mg Tbl;Placebo P-Tablet
6 Effects of the SGLT2-inhibitor Empagliflozin on Patients With Chronic SIADH - the SANDx Study Completed NCT03202667 Phase 2, Phase 3 Empagliflozin 25mg;Placebo
7 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of the Effects of Titrated Oral Tolvaptan Tablets in Patients With Hyponatremia Completed NCT00072683 Phase 3 tolvaptan
8 Multicenter, Randomized, Double-blind, Placebo-controlled, Efficacy and Safety Study of the Effects of Titrated Oral Tolvaptan Tablets in Patients With Hyponatremia, Study 2 Completed NCT00201994 Phase 3 Tolvaptan
9 Effects of the SGLT2-inhibitor Empagliflozin on Patients With SIADH - the SAND Study Completed NCT02874807 Phase 2, Phase 3 Empagliflozin
10 A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial Evaluating the Effect of a Vasopressin V2 Receptor Antagonist (SR121463B) on Serum Sodium in Patients With Dilutional Hyponatremia Completed NCT00274326 Phase 3 SR121463B
11 A Double-Blind, Randomized, Placebo-Controlled Multicenter Study Evaluating the Efficacy and Safety of Two Doses of Satavaptan (SR121463B) Versus Placebo in Patients With Dilutional Hyponatremia Due to the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Terminated NCT00728091 Phase 3 Satavaptan;placebo
12 Phase 3b, Multicenter, Randomized, Single-blind, Parallel Group Trial of the Effects of Titrated Oral SAMSCA(r) (Tolvaptan) 15, 30, or 60 mg QD Compared to Placebo Plus Fluid Restriction on Length of Hospital Stay and Symptoms in Subjects Hospitalized With Dilutional Hyponatremia Terminated NCT01227512 Phase 3 tolvaptan
13 A Phase 1b, Multicenter, Pilot, Randomized, Double-blind Trial to Determine the Pharmacokinetics and Pharmacodynamics of Orally Administered Tolvaptan 3.75, 7.5, and 15 mg Tablets in Subjects With Syndrome of Inappropriate Antidiuretic Hormone Secretion Completed NCT02009878 Phase 1, Phase 2 tolvaptan
14 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Escalation, Multicenter Study Evaluating the Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion. Completed NCT00032734 Phase 2 satavaptan (SR121463B)
15 Urea for Chronic Hyponatremia: A Pilot Study Recruiting NCT04588207 Phase 2 Urea
16 Comparison of the Vasopressin-2 Antagonist Tolvaptan and Fluid Restriction in the Treatment of Hyponatremia Following Pituitary Surgery Completed NCT04119206
17 Standardization of Fluids in Inpatient Settings Completed NCT03924674
18 A Prospective, Observational Study Measuring Sodium Improvement and Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia Secondary to SIADH in Italy Completed NCT02573077
19 Water Load Test Value for Hyponatremia Due to a Syndrome of Inappropriate Antidiuresis (SIAD) Completed NCT04256499
20 A Non Interventional, Retrospective Study on Real World Usage and Treatment Outcomes of Patients Treated With Tolvaptan for Hyponatraemia Due to the SIADH. Completed NCT02545101
21 An Observational, Retrospective Study to Describe the Extent of Adherence to the Spanish Society of Medical Oncology Algorithm for the Treatment of Hyponatraemia Secondary to SIADH in Oncology Patients in Spain (ALGA) Completed NCT02548845
22 Samsca Post-marketing General Drug Use-results Survey in Patients With Hyponatremia in Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in Japan Recruiting NCT04790175 Tolvaptan (SAMSCA)
23 Effect of Protein Supplementation on Plasma Sodium Levels and Urinary Urea Excretion in Patients With SIAD - a Monocentric Open- Label Proof-of-concept Study -The TREASURE Study Recruiting NCT04987385

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Genetic Tests for Syndrome of Inappropriate Antidiuretic Hormone

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Anatomical Context for Syndrome of Inappropriate Antidiuretic Hormone

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Organs/tissues related to Syndrome of Inappropriate Antidiuretic Hormone:

MalaCards : Pituitary, Kidney, Lung, Brain, Prostate, Bone Marrow, Cervix
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Publications for Syndrome of Inappropriate Antidiuretic Hormone

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Articles related to Syndrome of Inappropriate Antidiuretic Hormone:

(show top 50) (show all 1289)
# Title Authors PMID Year
1
Hyponatremia with Antidepressant: A Rare Side Effect from Duloxetine in a Child with Acute Leukemia. 62
35537479 2022
2
A 43-Day-Old Male With Respiratory Distress and Acute-Onset Hypotonia. 62
36254627 2022
3
Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1. 62
36420541 2022
4
Acute Intermittent Porphyria: Complete Phenotype in a Patient with p.Arg173Trp Variant in Thailand. 62
36329616 2022
5
Oncologic emergencies and urgencies: A comprehensive review. 62
35653456 2022
6
Human herpesvirus 6 (HHV-6) associated permanent hyponatremia in umbilical cord blood transplant recipient. 62
36372142 2022
7
Lymphocytic Hypophysitis in a Patient With Suspected Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH). 62
36397915 2022
8
Endocrine Disorders in Children with Brain Tumors: At Diagnosis, after Surgery, Radiotherapy and Chemotherapy. 62
36360345 2022
9
Fluid management in hospitalized pediatric patients. 62
35748381 2022
10
Hyponatremia Associated With Standard-Dose Trimethoprim-Sulfamethoxazole Use in an Immunocompetent Patient. 62
36301661 2022
11
Pathophysiology of Drug-Induced Hyponatremia. 62
36233678 2022
12
Red urine and a red herring - diagnosing rare diseases in the light of the COVID-19 pandemic. 62
34768287 2022
13
Anterior Mediastinal Neuroblastoma Associated with Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Morphologic, Immunohistochemical, and Genetic Case Report and Review of the Literature. 62
35188820 2022
14
Postoperative complications after endoscope-assisted transsphenoidal surgery for pituitary adenomas: a case series, systematic review, and meta-analysis of the literature. 62
35277844 2022
15
Symptomatic hyponatremia after ChAdOx1 nCoV-19 coronavirus disease-19 vaccination. 62
35818815 2022
16
Frequency of diencephalic syndrome in NMOSD. 62
34515964 2022
17
Syndrome of inappropriate antidiuretic hormone secretion. 62
35659417 2022
18
Hyponatremia elicits gene expression changes driving osteoclast differentiation and functions. 62
35843385 2022
19
A case of linezolid-induced SIADH in elderly and a review of the literature. 62
36066143 2022
20
Nationwide Readmission Rates and Hospital Charges for Patients With Surgical Evacuation of Nontraumatic Subdural Hematomas: Part 1-Craniotomy. 62
35551171 2022
21
Giant cystic hypothalamic hamartoma in an infant associated with persistent syndrome of inappropriate antidiuretic hormone secretion. 62
35048169 2022
22
Venous thromboembolism rates and risk factors following endoscopic skull base surgery. 62
34894093 2022
23
Differential diagnosis between syndrome of inappropriate antidiuretic hormone secretion and cerebral/renal salt wasting syndrome in children over 1 year: proposal for a simple algorithm. 62
34468821 2022
24
Eosinophilic granulomatosis with polyangiitis as a rare cause of the syndrome of inappropriate antidiuretic hormone secretion. 62
35895178 2022
25
Association of Hyponatremia on Mortality in Cryptococcal Meningitis: A Prospective Cohort. 62
35891691 2022
26
Complete resolution of paraneoplastic syndrome of inappropriate antidiuretic hormone secretion following thymic small-cell carcinoma thoracoscopic resection. 62
35894814 2022
27
A Nationwide Analysis of Aneurysmal Subarachnoid Hemorrhage Mortality, Complications, and Health Economics in the USA. 62
35881231 2022
28
Psychogenic Polydipsia in a Patient With a Clinical Triad. 62
35949782 2022
29
Kidney Transplant Recipient with Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Secondary to COVID-19 Pneumonia: A Case Report. 62
35527038 2022
30
Ketamine-Induced Syndrome of Inappropriate Antidiuretic Hormone Secretion and Hyponatremia. 62
35844311 2022
31
Clinical efficacy of urea treatment in syndrome of inappropriate antidiuretic hormone secretion. 62
35715573 2022
32
Changes in the Options for Management of Prolactin Secreting Pituitary Adenomas. 62
35832945 2022
33
Sodium and water perturbations in patients who had an acute stroke: clinical relevance and management strategies for the neurologist. 62
34969834 2022
34
Syndrome of inappropriate antidiuretic hormone secretion is associated with different proton pump inhibitor use: a pharmacovigilance study. 62
35590283 2022
35
Ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion in a patient with persistent lumbar pain: a case report. 62
35233721 2022
36
Rifabutin-Induced SIADH and Leucopenia in a Renal Transplant Recipient with Genitourinary Tract Tuberculosis: A Case Report and Review of the Literature. 62
36160637 2022
37
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Related to Primary Hypothyroidism-associated Pituitary Enlargement. 62
35415987 2022
38
Syndrome of inappropriate antidiuretic hormone presenting with recurrent hiccups in a case of small cell neuroendocrine carcinoma of the lung with concomitant pulmonary tuberculosis. 62
35775554 2022
39
Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Ayahuasca Use in a Satanic Ritual: A Case Report. 62
35607567 2022
40
The management and outcome of hyponatraemia following transsphenoidal surgery: a retrospective observational study. 62
35079890 2022
41
Atypical Case of Lyme Neuroborreliosis With Hyponatremia. 62
35619853 2022
42
Covid-19, the thyroid and the pituitary - The real state of play. 62
35065920 2022
43
Sodium and Potassium Dysregulation in the Patient With Cancer. 62
35817524 2022
44
A Patient's Six-Month Journey From Low Sodium to Blue Toes to Stroke: Non-infective Thrombotic Endocarditis Due to Non-small Cell Lung Cancer. 62
35475040 2022
45
Aetiological diagnosis of hyponatraemia in non-critical patients on total parenteral nutrition: A prospective multicentre study. 62
35396114 2022
46
Robot-assisted, real-time, MRI-guided laser interstitial thermal therapy for pediatric patients with hypothalamic hamartoma: surgical technique, pitfalls, and initial results. 62
35334464 2022
47
Severe hyponatraemia in two patients with breast cancer caused by low-dose cyclophosphamide and precipitated by aprepitant. 62
35318203 2022
48
Analysis of the Frequency and Onset Time of Hyponatremia/Syndrome of Inappropriate Antidiuretic Hormone Induced by Antidepressants or Antipsychotics. 62
34210184 2022
49
Do the etiology of hyponatremia and serum sodium levels affect the length of hospital stay in geriatric patients with hyponatremia? 62
35291493 2022
50
Syndrome of inappropriate antidiuretic hormone secretion associated with an ovarian immature teratoma: A case report and review of the literature. 62
35531360 2022
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Variations for Syndrome of Inappropriate Antidiuretic Hormone

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Expression for Syndrome of Inappropriate Antidiuretic Hormone

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Search GEO for disease gene expression data for Syndrome of Inappropriate Antidiuretic Hormone.
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Pathways for Syndrome of Inappropriate Antidiuretic Hormone

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GO Terms for Syndrome of Inappropriate Antidiuretic Hormone

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Sources for Syndrome of Inappropriate Antidiuretic Hormone

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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