Aliases & Classifications for Synostosis

MalaCards integrated aliases for Synostosis:

Name: Synostosis 12 55 44 15

Classifications:



External Ids:

Disease Ontology 12 DOID:11971
MeSH 44 D013580
UMLS 73 C0039093

Summaries for Synostosis

Disease Ontology : 12 A dysostosis that results in abnormal fusing of adjacent bones.

MalaCards based summary : Synostosis is related to humeroradial synostosis and radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome. An important gene associated with Synostosis is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways/superpathways are PAK Pathway and Pathways in cancer. The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and bone marrow, and related phenotypes are growth/size/body region and craniofacial

Wikipedia : 76 Synostosis (plural: synostoses) is fusion of two bones. It can be normal in puberty, fusion of the... more...

Related Diseases for Synostosis

Diseases related to Synostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 humeroradial synostosis 33.9 FGFR2 NOG
2 radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome 33.8 HOXA11 MECOM
3 spondylocarpotarsal synostosis syndrome 33.7 FLNB MYH3
4 radioulnar synostosis 33.2 FGFR1 FGFR2 HOXA11 LRP4 MECOM
5 muenke syndrome 32.2 EFNB1 FGFR1 FGFR2 FGFR3 RAB23 TWIST1
6 isolated brachycephaly 32.0 FGFR3 TCF12 TWIST1
7 chromosome 2q35 duplication syndrome 31.7 FGFR2 FGFR3 GLI3 NOG
8 saethre-chotzen syndrome 31.5 FGFR1 FGFR2 FGFR3 MSX2 TWIST1
9 isolated plagiocephaly 31.5 FGFR3 TCF12 TWIST1
10 apert syndrome 31.2 FGFR1 FGFR2 FGFR3 GLI3 RAB23 TWIST1
11 hemifacial hyperplasia 31.0 EFNB1 FGFR2 FGFR3
12 plagiocephaly 30.9 FGFR1 FGFR2 FGFR3 TWIST1
13 achondroplasia 30.3 FGFR1 FGFR2 FGFR3
14 chiari malformation 30.2 FGFR3 LRP4
15 strabismus 29.7 FGFR2 FGFR3 TWIST1
16 crouzon syndrome 29.4 FGFR1 FGFR2 FGFR3 MSX2
17 craniosynostosis 28.7 EFNB1 FGFR1 FGFR2 FGFR3 MSX2 NELL1
18 congenital radioulnar synostosis 12.3
19 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 12.3
20 radioulnar synostosis-microcephaly-scoliosis syndrome 12.1
21 radioulnar synostosis with amegakaryocytic thrombocytopenia 2 12.1
22 radioulnar synostosis with microcephaly, short stature, scoliosis, and mental retardation 11.9
23 humeroradioulnar synostosis 11.9
24 lambdoid synostosis 11.9
25 coronal synostosis, syndactyly and jejunal atresia 11.9
26 tibio-fibular synostosis 11.9
27 humero-ulnar synostosis 11.9
28 radioulnar synostosis, radial ray abnormalities, and severe malformations in the male 11.9
29 radioulnar synostosis, unilateral, with developmental retardation and hypotonia 11.8
30 radio-ulnar synostosis type 1 11.8
31 radio-ulnar synostosis type 2 11.8
32 craniosynostosis-hydrocephalus-arnold-chiari malformation type i-radioulnar synostosis syndrome 11.8
33 humeroradial synostosis with craniofacial anomalies 11.7
34 cleft palate colobomata radial synostosis deafness 11.7
35 congenital heart disease radio ulnar synostosis mental retardation 11.7
36 synostosis of talus and calcaneus short stature 11.7
37 deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome 11.7
38 humero-radial synostosis, unilateral 11.7
39 humero-radial synostosis, bilateral 11.7
40 humero-radio-ulnar synostosis, unilateral 11.7
41 humero-radio-ulnar synostosis, bilateral 11.7
42 radio-ulnar synostosis, unilateral 11.7
43 radio-ulnar synostosis, bilateral 11.7
44 humero-ulnar synostosis, unilateral 11.7
45 humero-ulnar synostosis, bilateral 11.7
46 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 11.7
47 antley-bixler syndrome 11.7
48 mesomelic dysplasia, kantaputra type 11.5
49 synostoses, tarsal, carpal, and digital 11.4
50 jorgenson lenz syndrome 11.3

Graphical network of the top 20 diseases related to Synostosis:



Diseases related to Synostosis

Symptoms & Phenotypes for Synostosis

MGI Mouse Phenotypes related to Synostosis:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.41 MECOM IFT122 LRP4 MSX2 NELL1 TCF12
2 craniofacial MP:0005382 10.4 MECOM IFT122 LRP4 MSX2 NELL1 NOG
3 limbs/digits/tail MP:0005371 10.39 HOXA11 MECOM IFT122 LRP4 MSX2 RAB23
4 mortality/aging MP:0010768 10.39 HOXA11 MECOM IFT122 LRP4 MSX2 RAB23
5 cellular MP:0005384 10.38 LRP4 HOXA11 MECOM IFT122 NOG TWIST1
6 behavior/neurological MP:0005386 10.32 GSC LRP4 MECOM MSX2 NELL1 TCF12
7 embryo MP:0005380 10.31 LRP4 MECOM IFT122 MSX2 RAB23 NOG
8 cardiovascular system MP:0005385 10.27 GSC MECOM IFT122 NOG MSX2 TWIST1
9 digestive/alimentary MP:0005381 10.25 IFT122 MSX2 TWIST1 NOG FGFR1 EFNB1
10 nervous system MP:0003631 10.24 LRP4 MECOM IFT122 MSX2 RAB23 TCF12
11 endocrine/exocrine gland MP:0005379 10.22 GSC LRP4 HOXA11 NOG MSX2 TCF12
12 integument MP:0010771 10.22 LRP4 MECOM MSX2 RAB23 NOG EFNB1
13 hearing/vestibular/ear MP:0005377 10.15 MECOM MSX2 NOG EFNB1 FGFR2 FGFR1
14 reproductive system MP:0005389 9.96 LRP4 HOXA11 MECOM NOG FGFR1 EFNB1
15 muscle MP:0005369 9.95 GSC MECOM NOG MSX2 TWIST1 FGFR1
16 renal/urinary system MP:0005367 9.87 LRP4 HOXA11 NOG FGFR1 FGFR2 FGFR3
17 skeleton MP:0005390 9.86 HOXA11 MECOM LRP4 MSX2 RAB23 NELL1
18 respiratory system MP:0005388 9.85 LRP4 MECOM NELL1 NOG EFNB1 FGFR2
19 vision/eye MP:0005391 9.32 GSC IFT122 MSX2 RAB23 NOG FGFR1

Drugs & Therapeutics for Synostosis

Drugs for Synostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 3,Not Applicable 1197-18-8 5526
2 Antifibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
3 Coagulants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
4 Hemostatics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Analgesics Phase 4
6 Peripheral Nervous System Agents Phase 4
7 Skullcap Nutraceutical Phase 4,Phase 1
8
Aminocaproic Acid Approved, Investigational Phase 2,Phase 1 60-32-2 564
9
Menthol Approved Not Applicable 2216-51-5 16666
10
Iron Approved Not Applicable 7439-89-6 23925
11
Bilirubin Not Applicable 635-65-4 5280352
12 Anti-Bacterial Agents Not Applicable
13 Antibiotics, Antitubercular Not Applicable
14 Anti-Infective Agents Not Applicable
15 Antitubercular Agents Not Applicable
16 Epoetin alfa Not Applicable 113427-24-0
17 Ferrous fumarate Not Applicable
18 Hematinics Not Applicable
19 Micronutrients Not Applicable
20 Trace Elements Not Applicable
21 Calcium, Dietary Not Applicable
22 Calamus Nutraceutical Not Applicable

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis Surgery Completed NCT02188576 Phase 4 high dose TXA;Low dose TXA
2 Tranexamic Acid for Craniofacial Surgery Terminated NCT00722436 Phase 4 Tranexamic acid;saline
3 NSAIDs for Pain After Ankle Fracture Surgery Withdrawn NCT02281968 Phase 4 Naproxen;Placebo
4 Comparison of a Bone Product to Bone Dust in Ossification of Small Calvarial Defects. Withdrawn NCT01006148 Phase 4
5 Blood Loss and Transfusion Requirement in Infants Treated With Tranexamic Acid Unknown status NCT01094977 Phase 3 Tranexamic Acid;Tranexamic Acid;Saline Placebo
6 Efficacy of Amicar for Children Having Craniofacial Surgery Active, not recruiting NCT02229968 Phase 2 Amicar (ε-aminocaproic acid);normal saline
7 Stem Cells and Tibial Fractures Completed NCT00632034 Phase 1
8 Amicar Pharmacokinetics of Children Having Craniofacial Surgery Completed NCT00912119 Phase 1 Epsilon-Aminocaproic Acid;Epsilon-Aminocaproic Acid;Epsilon-Aminocaproic Acid;Epsilon-Aminocaproic Acid
9 Mononucleotide Autologous Stem Cells and Demineralized Bone Matrix in the Treatment of Non Union/Delayed Fractures Unknown status NCT01435434 Not Applicable
10 The Effect of Gender on the Consumption of Pain Medication in Infants Undergoing Craniosynostosis Repair or Untethering of Cord in ITU Unknown status NCT01996163
11 Treatment of Displaced Lateral Clavicle Fractures Using a Locking Compression Plate With Lateral Extension Completed NCT02256059
12 MRI for Non-invasive Evaluation of Brain Stress Completed NCT01898650 Not Applicable
13 Evaluation of Effects of Clavicular Hook Plate on Subacromial Space Completed NCT01205763
14 Trauma Expectation Factor Trauma Outcome Measure Completed NCT01126398
15 Qualitative and Quantitative Study Which Aims to Determine the Specifics of the Announcement for the Diagnosis of Patients With Craniosynostosis and Their Parents to Better Support Them in Their Care Completed NCT02287805
16 Effect of Tranexamic Acid Based on Pharmacokinetics in Pediatric Patients Undergoing Craniosynostosis Surgery: Randomized Controlled Trial Completed NCT02180321 Not Applicable Tranexamic Acid;normal saline
17 Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary Results Completed NCT01672619
18 Genetic Analysis of Craniosynostosis, Philadelphia Type Completed NCT00367796
19 Child and Infant Learning Project Completed NCT00077831
20 Treatment of Cranial Molding Deformities in Preterm Infants Completed NCT02366936 Not Applicable
21 National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions Completed NCT01322165
22 Genetic Analysis of Fraser Syndrome and Fryns Syndrome Completed NCT00032877
23 Transtibial Amputation Outcomes Study Recruiting NCT01821976 Not Applicable
24 Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull Bones Recruiting NCT03025763
25 Cancer in Inherited Bone Marrow Failure Syndromes Recruiting NCT00027274
26 Randomized Trial to Assess PO Versus IV Antibiotics Recruiting NCT01714596 Not Applicable
27 Comparison of the Rate of Preoperative Haemoglobin After Administration of Epoetin Alpha Associated With an Oral Medical Supplementation Versus Intravenous Before Surgery of Craniosynostosis at the Child Recruiting NCT03231085 Not Applicable Ferrous fumarate
28 Optic Nerve Sheath Diameter in Craniosynostosis Recruiting NCT03131245
29 Comparison of Scar Formation in Syndactyly Release Surgery With Full Thickness Skin Graft Versus Skin Graft Substitute Recruiting NCT03107546 Not Applicable
30 Treatment of Proximal Interphalangeal Joint Injuries. Clinical Efficiency of Syndactyly Treatment and Digital Compression Recruiting NCT02548260 Not Applicable
31 Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis Repair Recruiting NCT02483702 Not Applicable
32 Pathogenetic Basis of Aortopathy and Aortic Valve Disease Recruiting NCT03440697
33 Bohring-Opitz Syndrome and ASXL Registry Recruiting NCT03303716
34 Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis) Recruiting NCT00106977
35 Syndactyly Versus Closed Reduction in 5th Metacarpal Neck Fracture Active, not recruiting NCT03434587 Not Applicable
36 Syndactyly Repair: Comparison of Skin Graft and No Skin Graft Techniques Active, not recruiting NCT01416090
37 Osteogenic Profiling of Tissue From Children With Craniosynostosis Active, not recruiting NCT00773643 Not Applicable
38 Anterior Odontoid Screw Osteosynthesis in Treatment of Type 2 Odontoid Fracture Not yet recruiting NCT03355703
39 Occipito-Cervical Stabilization Using Occipital Condyle Screw Not yet recruiting NCT03250611 Not Applicable
40 Vertebral Column Resection (VCR) in Congenital Kyphoscoliosis (CKS) Not yet recruiting NCT03524027 Not Applicable
41 Cranial Cup Use for the Prevention of Positional Head Shape Deformity in the NICU Terminated NCT01218087 Not Applicable
42 Endoscopic Treatment for Isolated, Single Suture Craniosynostosis Withdrawn NCT00769847
43 Hanger Helmet Study Withdrawn NCT02561728 Not Applicable

Search NIH Clinical Center for Synostosis

Cochrane evidence based reviews: synostosis

Genetic Tests for Synostosis

Anatomical Context for Synostosis

MalaCards organs/tissues related to Synostosis:

41
Bone, Skin, Bone Marrow, Brain, Thyroid, Eye, Testes

Publications for Synostosis

Articles related to Synostosis:

(show top 50) (show all 720)
# Title Authors Year
1
Minimally Invasive, Spring-Assisted Correction of Sagittal Suture Synostosis: Technique, Outcome, and Complications in 83 Cases. ( 29036024 )
2018
2
Defining and Correcting Asymmetry in Isolated Unilateral Frontosphenoidal Synostosis: Differences in Orbital Shape, Facial Scoliosis, and Skullbase Twist Compared to Unilateral Coronal Synostosis. ( 29065043 )
2018
3
Surgical Treatment of Unicoronal Synostosis: A Simplified Technique without Orbital Osteotomy. ( 29261518 )
2018
4
Adult Chiari Type 1 Malformation with Holocord Syringomyelia Associated with Sagittal Synostosis. ( 29354335 )
2018
5
Virtual modeling, stereolithography, and intraoperative CT guidance for the optimization of sagittal synostosis reconstruction: a technical note. ( 29460063 )
2018
6
A Review Of Referral Patterns For Sagittal Synostosis In Ireland: 2008-2013. ( 29869852 )
2018
7
Recessive Spondylocarpotarsal Synostosis Syndrome Due to Compound Heterozygosity for Variants in MYH3. ( 29805041 )
2018
8
Isolated Intraorbital Frontosphenoidal Synostosis. ( 29068968 )
2018
9
Discussion: Minimally Invasive, Spring-Assisted Correction of Sagittal Suture Synostosis: Technique, Outcome, and Complications in 83 Cases. ( 29369994 )
2018
10
A MECOM variant in an African American child with radioulnar synostosis and thrombocytopenia. ( 29200407 )
2018
11
Editorial. Endoscopic synostosis surgery: case closed. Or open? Or in between? ( 29979134 )
2018
12
The reverse SauvAc-Kapandji procedure for the treatment of (posttraumatic) proximal radioulnar synostosis. ( 29520493 )
2018
13
Subsegmental Osteotomy Technique With Distraction Osteogenesis for Natural Frontal Contouring in Metopic Synostosis. ( 29649371 )
2018
14
Seven additional families with spondylocarpotarsal synostosis syndrome with novel biallelic deleterious variants in FLNB. ( 29566257 )
2018
15
Isolated Post-Shunt Metopic Synostosis and Neural Tube Defects. ( 29561489 )
2018
16
Cognitive, behavioral and psychological functioning in children with metopic synostosis: a meta-analysis examining the impact of surgical status. ( 29482450 )
2018
17
Normalization of Speech Processing After Whole-Vault Cranioplasty in Sagittal Synostosis. ( 29621073 )
2018
18
Length of synostosis and segmented intracranial volume correlate with age in patients with non-syndromic sagittal synostosis. ( 29067505 )
2018
19
Expanding the phenotypic and genetic spectrum of radioulnar synostosis associated hematological disease. ( 29519864 )
2018
20
Spring-Mediated Cranioplasty in Sagittal Synostosis: Does Age at Placement Affect Expansion? ( 29381616 )
2018
21
Temporal Progression of Craniofacial Dysmorphology in Unilateral Coronal Synostosis: A Mechanistic Hypothesis. ( 29762326 )
2018
22
Non-syndromic bilateral ulnar aplasia with humero-radial synostosis and oligo-ectro-dactyly. ( 29427337 )
2018
23
Three-dimensional analysis of deformities of the radius and ulna in congenital proximal radioulnar synostosis. ( 29402171 )
2018
24
Delayed Chronic Subdural Hematoma after Total Cranial Vault Reconstruction for Sagittal Synostosis. ( 29672313 )
2018
25
Distal tibiofibular synostosis following non-operative treatment of ankle fractures. ( 29315039 )
2018
26
Posttraumatic Proximal Radioulnar Synostosis after Closed Reduction for a Radial Neck and Olecranon Fracture. ( 29805828 )
2018
27
Proximal tibiofibular synostosis. ( 29125821 )
2017
28
Effect of Preoperative Molding Helmet in Patients With Sagittal Synostosis. ( 28549045 )
2017
29
Pathological fracture in a patient with an untreated congenital metacarpal synostosis. ( 28193122 )
2017
30
Comparing Outcomes and Cost of 3 Surgical Treatments for Sagittal Synostosis: A Retrospective Study Including Procedure-Related Cost Analysis. ( 28449032 )
2017
31
Squamous Suture Synostosis: A Review With Emphasis on Cranial Morphology and Involvement of Other Cranial Sutures. ( 27831981 )
2017
32
Spondylocarpotarsal synostosis syndrome. A rare case of short stature and congenital scoliosis. ( 29263747 )
2017
33
A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFI^ signaling and cause autosomal dominant spondylocarpotarsal synostosis. ( 28205584 )
2017
34
Multidirectional Cranial Distraction Osteogenesis with Simplified Modifications for Treating Sagittal Synostosis. ( 29184744 )
2017
35
Filamin B Loss-of-Function Mutation in Dimerization Domain Causes Autosomal-Recessive Spondylocarpotarsal Synostosis Syndrome with Rib Anomalies. ( 28145000 )
2017
36
Temporal Deformity Objectively Measured Before and After Surgery for Metopic Synostosis: Retrusion Rather than Hollowing. ( 28885443 )
2017
37
Transtibial Amputation Outcomes Study (TAOS): Comparing Transtibial Amputation With and Without a Tibiofibular Synostosis (Ertl) Procedure. ( 28323804 )
2017
38
KienbAPck Disease in a Patient with Congenital Synostosis of the Lunate and the Triquetrum: A Case Report. ( 29244670 )
2017
39
Cranioplasty without Periosteal Dissection Reduces Blood Loss in Pi-Plasty Surgery for Sagittal Synostosis. ( 28693016 )
2017
40
A case of failure to correct humerus-radius synostosis and thumb hypoplasia. ( 28823203 )
2017
41
Bilateral capitato-hamato-trapezoidal synostosis. ( 28713069 )
2017
42
Treated Unilateral Lambdoid Synostosis Using Cranium Distraction Osteogenesis With Z-shaped Osteotomy. ( 28059851 )
2017
43
Delayed Presentation of Isolated Sagittal Synostosis With Raised Intracranial Pressure and Secondary Chiari Malformation With Cervical Syringomyelia. ( 28582306 )
2017
44
Congenital radioulnar synostosis. ( 28828125 )
2017
45
Scaphoid Fracture in a Patient with a Scaphotrapezial Synostosis: A Case Report and Literature Review. ( 28197353 )
2017
46
A 590 kb deletion caused by non-allelic homologous recombination between two LINE-1 elements in a patient with mesomelia-synostosis syndrome. ( 28328141 )
2017
47
Twenty-Year Review of a Single Surgeon's Experience Using a Unique Surgical Technique to Correct Lambdoidal Synostosis. ( 28962092 )
2017
48
The use of indomethacin in the prevention of postoperative radioulnar synostosis after distal biceps repair. ( 28104092 )
2017
49
Circumferential Adipofascial Graft for Prevention of Recurrence of Posttraumatic Radioulnar Synostosis. ( 29107381 )
2017
50
The Degree of Surgical Frontal Volume Correction in Metopic Synostosis Determines Long-Term Outcomes. ( 28358760 )
2017

Variations for Synostosis

Expression for Synostosis

Search GEO for disease gene expression data for Synostosis.

Pathways for Synostosis

GO Terms for Synostosis

Cellular components related to Synostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.92 FGFR1 FGFR2 FGFR3 LRP4

Biological processes related to Synostosis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.95 FGFR1 FGFR3 HOXA11 NOG
2 central nervous system development GO:0007417 9.92 FGFR1 FGFR2 GLI3 NOG
3 negative regulation of signal transduction GO:0009968 9.91 FGFR1 FGFR2 FGFR3
4 osteoblast differentiation GO:0001649 9.9 MSX2 NOG TWIST1
5 phosphatidylinositol phosphorylation GO:0046854 9.9 FGFR1 FGFR2 FGFR3
6 anterior/posterior pattern specification GO:0009952 9.9 GLI3 HOXA11 MSX2
7 lung development GO:0030324 9.89 FGFR1 FGFR2 GLI3
8 positive regulation of neuron differentiation GO:0045666 9.89 FGFR1 GDF5 TCF12
9 fibroblast growth factor receptor signaling pathway GO:0008543 9.89 FGFR1 FGFR2 FGFR3
10 neural tube closure GO:0001843 9.89 IFT122 NOG TWIST1
11 in utero embryonic development GO:0001701 9.89 FGFR1 FGFR2 GLI3 NOG TWIST1
12 muscle organ development GO:0007517 9.88 FLNB MYH3 TCF12 TWIST1
13 cartilage development GO:0051216 9.87 GDF5 MSX2 NOG
14 positive regulation of kinase activity GO:0033674 9.87 FGFR1 FGFR2 FGFR3
15 negative regulation of cell differentiation GO:0045596 9.86 GLI3 NOG TWIST1
16 BMP signaling pathway GO:0030509 9.86 GDF5 LRP4 MSX2 NOG
17 negative regulation of epithelial cell proliferation GO:0050680 9.85 FGFR2 GDF5 IFT122
18 positive regulation of epithelial cell proliferation GO:0050679 9.85 FGFR2 NOG TWIST1
19 positive regulation of osteoblast differentiation GO:0045669 9.85 GLI3 MSX2 NELL1
20 wound healing GO:0042060 9.85 FGFR2 GLI3 MSX2 NOG
21 bone development GO:0060348 9.84 FGFR2 HOXA11 TWIST1
22 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.83 FGFR1 FGFR2 FGFR3
23 embryonic skeletal system morphogenesis GO:0048704 9.83 GLI3 GSC TWIST1
24 ureteric bud development GO:0001657 9.82 FGFR1 FGFR2 NOG
25 chondrocyte differentiation GO:0002062 9.8 FGFR1 FGFR3 GDF5
26 odontogenesis GO:0042476 9.79 FGFR2 MSX2 TWIST1
27 anatomical structure development GO:0048856 9.77 GLI3 LRP4 MECOM
28 bone morphogenesis GO:0060349 9.77 FGFR2 FGFR3 MSX2
29 signal transduction involved in regulation of gene expression GO:0023019 9.73 GSC MSX2
30 embryonic digestive tract morphogenesis GO:0048557 9.73 FGFR2 GLI3
31 limb development GO:0060173 9.73 GLI3 IFT122 LRP4 NOG
32 endocardial cushion morphogenesis GO:0003203 9.72 NOG TWIST1
33 ear development GO:0043583 9.72 FGFR1 GSC
34 dorsal/ventral pattern formation GO:0009953 9.72 GLI3 HOXA11 IFT122 LRP4 NOG
35 embryonic skeletal joint morphogenesis GO:0060272 9.71 HOXA11 NOG
36 organ induction GO:0001759 9.71 FGFR1 HOXA11
37 proximal/distal pattern formation GO:0009954 9.71 GLI3 HOXA11 LRP4
38 hindlimb morphogenesis GO:0035137 9.7 GDF5 TWIST1
39 branching involved in salivary gland morphogenesis GO:0060445 9.7 FGFR1 FGFR2
40 membranous septum morphogenesis GO:0003149 9.7 FGFR2 NOG
41 middle ear morphogenesis GO:0042474 9.7 FGFR1 GSC NOG
42 embryonic digit morphogenesis GO:0042733 9.7 GLI3 HOXA11 IFT122 LRP4 MSX2 NOG
43 outer ear morphogenesis GO:0042473 9.69 FGFR1 TWIST1
44 positive regulation of chondrocyte differentiation GO:0032332 9.69 GDF5 GLI3 HOXA11
45 lung-associated mesenchyme development GO:0060484 9.68 FGFR1 FGFR2
46 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.67 GLI3 IFT122
47 embryonic forelimb morphogenesis GO:0035115 9.67 HOXA11 IFT122 MSX2 TWIST1
48 BMP signaling pathway involved in heart development GO:0061312 9.66 MSX2 NOG
49 cranial suture morphogenesis GO:0060363 9.66 MSX2 TWIST1
50 mesenchymal cell differentiation GO:0048762 9.65 FGFR1 FGFR2 NOG

Molecular functions related to Synostosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.95 FGFR1 FGFR2 LRP4 NOG TCF12 TWIST1
2 nucleotide binding GO:0000166 9.72 FGFR1 FGFR2 FGFR3 MYH3 RAB23
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.69 FGFR1 FGFR2 FGFR3
4 MAP kinase kinase kinase activity GO:0004709 9.67 FGFR1 FGFR2 FGFR3
5 mitogen-activated protein kinase kinase binding GO:0031434 9.63 FGFR1 FGFR2 FGFR3
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.61 FGFR1 FGFR2 FGFR3
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.54 FGFR1 FGFR2 FGFR3
8 1-phosphatidylinositol-3-kinase activity GO:0016303 9.33 FGFR1 FGFR2 FGFR3
9 fibroblast growth factor binding GO:0017134 9.13 FGFR1 FGFR2 FGFR3
10 fibroblast growth factor-activated receptor activity GO:0005007 8.8 FGFR1 FGFR2 FGFR3
11 protein binding GO:0005515 10.21 BHLHA9 EFNB1 FGFR1 FGFR2 FGFR3 FLNB
12 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 10.01 BHLHA9 GLI3 GSC HOXA11 MECOM MSX2

Sources for Synostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....