MCID: SYN031
MIFTS: 48

Synovial Chondromatosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Synovial Chondromatosis

MalaCards integrated aliases for Synovial Chondromatosis:

Name: Synovial Chondromatosis 53
Synovial Osteochondromatosis 53 73
Chondromatosis, Synovial 73

Classifications:



External Ids:

Summaries for Synovial Chondromatosis

NIH Rare Diseases : 53 Synovial chondromatosis is a type of non-cancerous tumor that arises in the lining of a joint. The knee is most commonly affected, however it can affect any joint. The tumors begin as small nodules of cartilage. These nodules can separate and become loose within the joint. Some tumors may be no larger than a grain of rice. Synovial chondromatosis most commonly occurs in adults ages 20 to 50. Signs and symptoms may include pain, swelling, a decreased range of motion, and locking of the joint. The exact underlying cause of the condition is unknown. Treatment may involve surgery to remove the tumor. Recurrence of the condition is common.

MalaCards based summary : Synovial Chondromatosis, also known as synovial osteochondromatosis, is related to osteochondroma and osteoporosis, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Synovial Chondromatosis is BMP2 (Bone Morphogenetic Protein 2), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Affiliated tissues include bone, endothelial and lung, and related phenotypes are cellular and cardiovascular system

Wikipedia : 76 Synovial chondromatosis (synonyms include synovial osteochondromatosis, primary synovial... more...

Related Diseases for Synovial Chondromatosis

Diseases related to Synovial Chondromatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 osteochondroma 30.6 BMP2 FGF2 FGF9 FGFR1 FGFR3
2 osteoporosis 29.3 BMP2 BMP4 COL1A1 COL2A1 NOG RUNX2
3 synovial chondromatosis, familial, with dwarfism 12.4
4 chondrosarcoma 10.7
5 osteoarthritis 10.4
6 synovitis 10.4
7 villonodular synovitis 10.4
8 pigmented villonodular synovitis 10.3
9 bursitis 10.3
10 radiculopathy 10.3
11 joint disorders 10.2
12 arthropathy 10.2
13 neuropathy 10.2
14 rheumatoid arthritis 10.2
15 arthritis 10.2
16 hemangioma 10.2
17 plagiocephaly 10.2 FGFR1 FGFR3
18 renal hypodysplasia/aplasia 3 10.2 BMP4 FGFR3
19 osteoglophonic dysplasia 10.2 FGFR1 FGFR3
20 clivus chordoma 10.1 FGF2 FGFR1
21 polydactyly, postaxial, type a1 10.1 BMP4 GLI3
22 jackson-weiss syndrome 10.1 FGFR1 FGFR3
23 ossification of the posterior longitudinal ligament of spine 10.1 BMP2 RUNX2
24 skeletal dysplasias 10.1 COL2A1 FGFR3
25 crouzon syndrome 10.1 FGF2 FGFR1 FGFR3
26 lacrimoauriculodentodigital syndrome 10.1 FGF9 FGFR1 FGFR3
27 tympanosclerosis 10.1 BMP2 COL1A1 COL2A1
28 legg-calve-perthes disease 10.1
29 popliteal cyst 10.1
30 tendinitis 10.1
31 stickler syndrome 10.1
32 epicondylitis 10.1
33 calcific tendinitis 10.1
34 acromegaly 10.1
35 melorheostosis 10.1
36 fibrodysplasia ossificans progressiva 10.0
37 systemic lupus erythematosus 10.0
38 sarcoma, synovial 10.0
39 sarcoma 10.0
40 osteopoikilosis 10.0
41 tarsal tunnel syndrome 10.0
42 relapsing polychondritis 10.0
43 pleomorphic adenoma 10.0
44 adenoma 10.0
45 synovial angioma 10.0
46 lupus erythematosus 10.0
47 tenosynovitis 10.0
48 dwarfism 10.0
49 mycobacterium marinum 10.0
50 familial calcium pyrophosphate deposition 10.0

Graphical network of the top 20 diseases related to Synovial Chondromatosis:



Diseases related to Synovial Chondromatosis

Symptoms & Phenotypes for Synovial Chondromatosis

UMLS symptoms related to Synovial Chondromatosis:


arthralgia, metatarsalgia

MGI Mouse Phenotypes related to Synovial Chondromatosis:

46 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.42 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9
2 cardiovascular system MP:0005385 10.39 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9
3 craniofacial MP:0005382 10.38 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
4 digestive/alimentary MP:0005381 10.37 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
5 growth/size/body region MP:0005378 10.35 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
6 homeostasis/metabolism MP:0005376 10.35 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9
7 hearing/vestibular/ear MP:0005377 10.3 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9
8 mortality/aging MP:0010768 10.29 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9
9 embryo MP:0005380 10.28 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
10 behavior/neurological MP:0005386 10.27 BMP4 COL1A1 COL2A1 FGF2 FGF9 FGFR1
11 limbs/digits/tail MP:0005371 10.27 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
12 nervous system MP:0003631 10.21 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGFR1
13 hematopoietic system MP:0005397 10.2 BMP2 BMP4 COL1A1 FGF2 FGFR1 FGFR3
14 endocrine/exocrine gland MP:0005379 10.18 BMP4 COL1A1 FGF9 FGFR1 GLI3 NOG
15 immune system MP:0005387 10.18 BMP2 COL1A1 COL2A1 FGF9 FGFR1 FGFR3
16 integument MP:0010771 10.16 BMP4 COL1A1 FGF9 FGFR1 FGFR3 GLI3
17 normal MP:0002873 10.11 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
18 muscle MP:0005369 10.06 BMP4 COL1A1 FGF2 FGF9 FGFR1 NOG
19 reproductive system MP:0005389 10 BMP2 BMP4 COL1A1 FGF2 FGF9 FGFR1
20 renal/urinary system MP:0005367 9.97 BMP4 COL1A1 COL2A1 FGF9 FGFR1 FGFR3
21 no phenotypic analysis MP:0003012 9.95 BMP4 COL1A1 FGFR1 FGFR3 GLI3 RUNX2
22 respiratory system MP:0005388 9.85 BMP4 COL1A1 COL2A1 FGF9 FGFR3 GLI3
23 skeleton MP:0005390 9.77 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9
24 vision/eye MP:0005391 9.4 BMP4 COL1A1 COL2A1 FGF2 FGF9 FGFR1

Drugs & Therapeutics for Synovial Chondromatosis

Search Clinical Trials , NIH Clinical Center for Synovial Chondromatosis

Genetic Tests for Synovial Chondromatosis

Anatomical Context for Synovial Chondromatosis

MalaCards organs/tissues related to Synovial Chondromatosis:

41
Bone, Endothelial, Lung, Bone Marrow

Publications for Synovial Chondromatosis

Articles related to Synovial Chondromatosis:

(show top 50) (show all 695)
# Title Authors Year
1
Atypical synovial chondromatosis of the right knee: A case report. ( 29725385 )
2018
2
Intra- and extracapsular synovial chondromatosis of the temporomandibular joint: Rare case and review of the literature. ( 29796269 )
2018
3
Arthroscopic and Endoscopic Technique for Subcoracoid Synovial Chondromatosis of the Shoulder Through a Medial Transpectoral Portal. ( 29881701 )
2018
4
Huge Bursitis and Bursal Synovial Osteochondromatosis associated with Scapular Osteochondroma Mimicking a Giant Calcific Mass of the Chest Wall: A Case Report. ( 29905601 )
2018
5
Long-Term Outcome of Hip Arthroplasty in the Setting of Synovial Chondromatosis. ( 29550167 )
2018
6
Synovial Chondromatosis in Patient Presenting with Chronic Venous Stasis Ulcers. ( 29655813 )
2018
7
Surgical Treatment of Synovial Chondromatosis in the Inferior Compartment of the Temporomandibular Joint With Articular Disc Involvement. ( 29303858 )
2018
8
Ulnar nerve palsy caused by synovial protrusion in synovial chondromatosis of the elbow: a case report and literature review. ( 29560039 )
2018
9
Temporomandibular joint synovial chondromatosis accompanying temporal bone proliferation: A case report. ( 29963487 )
2018
10
Reverse Shoulder Arthroplasty for Primary Synovial Osteochondromatosis of the Shoulder with Massive Rotator Cuff Tear and Marked Degenerative Arthropathy. ( 30061514 )
2018
11
'Stony' shoulder: an exuberant case of glenohumeral synovial chondromatosis with extra-articular extension. ( 30150347 )
2018
12
Arthroscopic treatment of synovial chondromatosis of the ankle. ( 30258827 )
2018
13
Bilateral symmetrical synovial chondromatosis of shoulder: a case report. ( 30258832 )
2018
14
Role of synovium-derived fibrous cartilage in temporomandibular joint synovial chondromatosis. ( 30290017 )
2018
15
Arthroscopic management of elbow synovial chondromatosis. ( 30290596 )
2018
16
Synovial Chondromatosis and Calcium Pyrophosphate Deposition of the Temporomandibular Joint: Challenging Diagnosis. ( 30334911 )
2018
17
Arthroscopic Management of Synovial Chondromatosis of the Temporomandibular Joint. Case Series and Systematic Review. ( 30344377 )
2018
18
Intuitive Hand-held Instrument for Loose Body Removal in Arthroscopic Synovial Chondromatosis Surgery. ( 30441079 )
2018
19
Radiological features of synovial chondromatosis affecting the temporomandibular joint: report of three cases. ( 30484200 )
2018
20
Remaining Loose Bodies after Arthroscopic Surgery Including Extensive Capsulectomy for Synovial Chondromatosis of the Hip. ( 30505405 )
2018
21
Synovial chondromatosis of the temporomandibular joint: report and analysis of 12 cases. ( 30557743 )
2018
22
Synovial osteochondromatosis of the shoulder: Case report and literature review. ( 27613313 )
2018
23
Recurrent erosive synovial osteochondromatosis of the wrist mimicking gouty tophi. ( 28977632 )
2018
24
Primary Synovial Osteochondromatosis of the Hip Joint Treated with Arthroscopic-assisted Mini-open Surgery-Two Case Reports. ( 30167410 )
2018
25
Intraarticular synovial osteochondromatosis of the elbow joint with radial nerve palsy. ( 30201477 )
2018
26
Posterior interosseous nerve palsy caused by synovial osteochondromatosis of the elbow analyzed by three-dimensional reconstruction: a case report. ( 30449285 )
2018
27
Multimodal ultrasonographic evaluation in a case with unossified primary synovial osteochondromatosis. ( 30534663 )
2018
28
Arthroscopic Management and Treatment of Synovial Chondromatosis and Talus Osteochondral Defect in the Ankle Joint. A Case Study. ( 29086752 )
2017
29
Synovial chondromatosis of the temporomandibular joint with intracranial extension-report of two cases. ( 28641900 )
2017
30
Arthroscopic Treatment of Synovial Chondromatosis in the Ankle Joint. ( 29503777 )
2017
31
Synovial osteochondromatosis in a 14-year-old boy with a history of Legg-Calve-Perthes disease. ( 28491198 )
2017
32
An unusual presentation of synovial chondromatosis of the knee in a 10-year-old girl. ( 28615116 )
2017
33
High Rate of Local Recurrence and Complications Following Total Knee Arthroplasty in the Setting of Synovial Chondromatosis. ( 28364965 )
2017
34
Temporomandibular joint synovial chondromatosis extending to the temporal bone: a report of two cases. ( 29142869 )
2017
35
Shoulder joint synovial chondromatosis presenting as multiple axillary masses: A case report. ( 29159809 )
2017
36
Primary synovial chondromatosis of the subtalar joint: case report and review of the literature. ( 28932921 )
2017
37
Bursal Synovial Chondromatosis Secondary to Underlying Osteochondroma in a Child. ( 29468100 )
2017
38
Malignant Transformation of Synovial Chondromatosis: A Systematic Review. ( 28694891 )
2017
39
Open surgery assisted with arthroscopy to treat synovial chondromatosis of the temporomandibular joint. ( 27769739 )
2017
40
Recurrent synovial chondromatosis of the temporomandibular joint: report of two cases. ( 28964665 )
2017
41
Synovial Chondromatosis ( 29262110 )
2017
42
Synovial chondromatosis of the temporomandibular joint with extension into the middle cranial fossa and internal carotid canal. ( 28314662 )
2017
43
A Case Report of Primary Synovial Chondromatosis with Bilateral Genu Valgum. ( 29242805 )
2017
44
Intermetatarsal bursa primary synovial chondromatosis: case report and review of the literature. ( 28914347 )
2017
45
Recurrent Extra- and Intra-articular Synovial Chondromatosis of the Ankle with Tarsal Tunnel Syndrome: A Rare Case Report. ( 28819605 )
2017
46
Reverse Total Shoulder Arthroplasty for the Treatment of Synovial Chondromatosis: A Case Report and Review of the Literature. ( 28497103 )
2017
47
Surgical management of medial humeral epicondylitis, cubital synovial osteochondromatosis and humeroradial subluxation in a cat. ( 28491453 )
2017
48
Synovial Chondromatosis: A Rare Differential Diagnosis of Hip Pain in a Child. ( 28819599 )
2017
49
Synovial Osteochondromatosis at the Carpometacarpal Joint of the Thumb. ( 28168072 )
2017
50
Left Knee Synovial Osteochondromatosis. ( 28363272 )
2017

Variations for Synovial Chondromatosis

Expression for Synovial Chondromatosis

Search GEO for disease gene expression data for Synovial Chondromatosis.

Pathways for Synovial Chondromatosis

Pathways related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGFR1
2
Show member pathways
13.63 BMP2 BMP4 FGF2 FGF9 FGFR1 FGFR3
3
Show member pathways
13.45 BMP2 BMP4 FGF2 FGF9 FGFR1 FGFR3
4
Show member pathways
13.32 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
5
Show member pathways
13.25 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
6
Show member pathways
13.22 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
7
Show member pathways
13.2 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
8
Show member pathways
12.96 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
9
Show member pathways
12.9 COL1A1 COL2A1 FGF2 FGF9 FGFR1 FGFR3
10
Show member pathways
12.86 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGFR1
11 12.7 FGF2 FGF9 FGFR1 FGFR3 TGFB3
12
Show member pathways
12.69 FGF2 FGF9 FGFR1 FGFR3
13
Show member pathways
12.68 FGF2 FGF9 FGFR1 TGFB3
14
Show member pathways
12.65 FGF2 FGF9 FGFR1 FGFR3
15
Show member pathways
12.64 FGF2 FGF9 FGFR1 FGFR3
16
Show member pathways
12.64 BMP2 BMP4 COL1A1 COL2A1 FGF2 TGFB3
17
Show member pathways
12.59 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
18 12.58 BMP2 BMP4 FGF2 FGF9 FGFR1 FGFR3
19 12.56 FGF2 FGF9 FGFR1 FGFR3
20
Show member pathways
12.52 FGF2 FGF9 FGFR1 FGFR3
21
Show member pathways
12.4 BMP2 BMP4 FGF2 NOG TGFB3
22
Show member pathways
12.39 FGF2 FGF9 FGFR1 FGFR3
23
Show member pathways
12.36 FGF2 FGF9 FGFR1 FGFR3
24
Show member pathways
12.34 FGF2 FGF9 FGFR1 FGFR3
25
Show member pathways
12.3 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
26
Show member pathways
12.22 FGF2 FGF9 FGFR1 FGFR3
27
Show member pathways
12.18 COL1A1 FGF2 FGFR1 FGFR3
28
Show member pathways
12.14 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
29
Show member pathways
12.11 FGF2 FGF9 FGFR1 FGFR3
30 12.08 BMP2 BMP4 TGFB3
31
Show member pathways
12.06 BMP2 BMP4 GLI3
32 12.05 FGF2 FGFR1 FGFR3
33 12.04 BMP4 FGF2 FGFR1 FGFR3
34 12 BMP4 FGF2 NOG SOX9
35 11.98 BMP2 BMP4 TGFB3
36
Show member pathways
11.97 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
37 11.85 GLI3 RUNX2 TGFB3
38
Show member pathways
11.81 FGF2 FGF9 FGFR1
39 11.8 FGF2 FGFR1 FGFR3 TGFB3
40 11.76 BMP2 BMP4 NOG TGFB3
41
Show member pathways
11.71 BMP2 BMP4 TGFB3
42
Show member pathways
11.69 BMP2 NOG RUNX2
43 11.64 BMP4 COL2A1 FGF2 FGFR1 FGFR3 SOX9
44 11.63 BMP2 BMP4 TGFB3
45
Show member pathways
11.59 FGF2 FGF9 FGFR3
46 11.59 BMP4 NOG RUNX2
47 11.57 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
48 11.54 BMP4 FGF2 NOG
49 11.42 FGF2 FGFR1 FGFR3
50 11.42 BMP4 FGF2 NOG TGFB3

GO Terms for Synovial Chondromatosis

Cellular components related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9
2 extracellular region GO:0005576 9.32 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9

Biological processes related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of canonical Wnt signaling pathway GO:0090090 9.99 BMP2 GLI3 NOG SOX9
2 central nervous system development GO:0007417 9.99 COL2A1 GLI3 NOG SOX9
3 phosphatidylinositol phosphorylation GO:0046854 9.98 FGF2 FGF9 FGFR1 FGFR3
4 lung development GO:0030324 9.97 BMP4 FGF9 FGFR1 GLI3
5 sensory perception of sound GO:0007605 9.96 COL1A1 COL2A1 FGFR1
6 activation of MAPK activity GO:0000187 9.96 BMP2 FGF2 TGFB3
7 BMP signaling pathway GO:0030509 9.96 BMP2 BMP4 NOG RUNX2
8 positive regulation of neuron differentiation GO:0045666 9.95 BMP2 BMP4 FGFR1
9 positive regulation of endothelial cell proliferation GO:0001938 9.94 BMP2 BMP4 FGF2
10 fibroblast growth factor receptor signaling pathway GO:0008543 9.94 FGF2 FGF9 FGFR1 FGFR3
11 cell fate commitment GO:0045165 9.93 BMP2 BMP4 SOX9
12 inner ear morphogenesis GO:0042472 9.93 COL2A1 FGF9 FGFR1
13 positive regulation of epithelial cell proliferation GO:0050679 9.93 BMP4 FGF9 NOG SOX9
14 cell development GO:0048468 9.92 BMP2 BMP4 TGFB3
15 regulation of MAPK cascade GO:0043408 9.92 BMP2 BMP4 TGFB3
16 SMAD protein signal transduction GO:0060395 9.92 BMP2 BMP4 TGFB3
17 embryonic digit morphogenesis GO:0042733 9.92 BMP4 GLI3 NOG
18 positive regulation of osteoblast differentiation GO:0045669 9.92 BMP2 BMP4 GLI3 RUNX2
19 odontogenesis of dentin-containing tooth GO:0042475 9.92 BMP2 BMP4 GLI3 RUNX2
20 somatic stem cell population maintenance GO:0035019 9.91 FGF2 NOG SOX9
21 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.91 BMP2 BMP4 TGFB3
22 embryonic limb morphogenesis GO:0030326 9.91 BMP4 FGF9 FGFR1 GLI3
23 wound healing GO:0042060 9.91 COL1A1 FGF2 GLI3 NOG TGFB3
24 positive regulation of cell division GO:0051781 9.9 FGF2 FGF9 TGFB3
25 ureteric bud development GO:0001657 9.89 BMP4 FGFR1 NOG
26 epithelial to mesenchymal transition GO:0001837 9.89 BMP2 NOG SOX9
27 positive regulation of cardiac muscle cell proliferation GO:0060045 9.89 FGF2 FGF9 FGFR1
28 cartilage development GO:0051216 9.89 BMP2 BMP4 COL2A1 NOG SOX9
29 mammary gland development GO:0030879 9.88 GLI3 SOX9 TGFB3
30 positive regulation of bone mineralization GO:0030501 9.88 BMP2 BMP4 TGFB3
31 protein localization to nucleus GO:0034504 9.88 BMP4 COL1A1 SOX9
32 inner ear development GO:0048839 9.88 BMP2 COL2A1 GLI3 TGFB3
33 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.88 FGF2 FGF9 FGFR1 FGFR3
34 face morphogenesis GO:0060325 9.87 COL1A1 NOG TGFB3
35 telencephalon development GO:0021537 9.87 BMP2 BMP4 GLI3
36 positive regulation of epithelial to mesenchymal transition GO:0010718 9.87 BMP2 BMP4 COL1A1 TGFB3
37 positive regulation of mesenchymal cell proliferation GO:0002053 9.86 FGF9 FGFR1 SOX9
38 skeletal system morphogenesis GO:0048705 9.86 COL1A1 COL2A1 FGFR1 RUNX2
39 anatomical structure formation involved in morphogenesis GO:0048646 9.85 BMP4 GLI3 NOG
40 positive regulation of chondrocyte differentiation GO:0032332 9.85 GLI3 RUNX2 SOX9
41 embryonic skeletal system development GO:0048706 9.85 BMP4 COL1A1 FGF9 NOG
42 osteoblast differentiation GO:0001649 9.85 BMP2 BMP4 COL1A1 FGF9 NOG RUNX2
43 regulation of cell differentiation GO:0045595 9.84 BMP4 FGFR1 GLI3 SOX9
44 endocardial cushion morphogenesis GO:0003203 9.83 BMP2 NOG SOX9
45 embryonic morphogenesis GO:0048598 9.83 BMP4 FGF2 GLI3
46 positive regulation of cartilage development GO:0061036 9.82 BMP2 BMP4 SOX9
47 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.8 BMP2 BMP4
48 branching morphogenesis of an epithelial tube GO:0048754 9.8 BMP4 GLI3
49 cardiac muscle cell differentiation GO:0055007 9.8 BMP2 BMP4
50 negative regulation of myoblast differentiation GO:0045662 9.8 BMP4 SOX9

Molecular functions related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.78 BMP2 BMP4 FGF2 TGFB3
2 protein tyrosine kinase activity GO:0004713 9.71 FGF2 FGF9 FGFR1 FGFR3
3 heparin binding GO:0008201 9.62 BMP4 FGF2 FGF9 FGFR1
4 bHLH transcription factor binding GO:0043425 9.56 RUNX2 SOX9
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.56 FGF2 FGF9 FGFR1 FGFR3
6 fibroblast growth factor receptor binding GO:0005104 9.55 FGF2 FGF9
7 fibroblast growth factor binding GO:0017134 9.54 FGFR1 FGFR3
8 transforming growth factor beta receptor binding GO:0005160 9.54 BMP2 BMP4 TGFB3
9 co-receptor binding GO:0039706 9.52 BMP2 BMP4
10 platelet-derived growth factor binding GO:0048407 9.51 COL1A1 COL2A1
11 BMP receptor binding GO:0070700 9.49 BMP2 BMP4
12 fibroblast growth factor-activated receptor activity GO:0005007 9.46 FGFR1 FGFR3
13 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.46 FGF2 FGF9 FGFR1 FGFR3
14 receptor-receptor interaction GO:0090722 9.43 FGF2 FGFR1
15 growth factor activity GO:0008083 9.35 BMP2 BMP4 FGF2 FGF9 TGFB3
16 1-phosphatidylinositol-3-kinase activity GO:0016303 8.92 FGF2 FGF9 FGFR1 FGFR3

Sources for Synovial Chondromatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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