MCID: SYN031
MIFTS: 41

Synovial Chondromatosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Synovial Chondromatosis

MalaCards integrated aliases for Synovial Chondromatosis:

Name: Synovial Chondromatosis 20 17
Synovial Osteochondromatosis 20 70
Chondromatosis, Synovial 70

Classifications:



External Ids:

UMLS 70 C0008476 C0029427

Summaries for Synovial Chondromatosis

GARD : 20 Synovial chondromatosis is a type of non-cancerous tumor that arises in the lining of a joint. The knee is most commonly affected, however it can affect any joint. The tumors begin as small nodules of cartilage. These nodules can separate and become loose within the joint. Some tumors may be no larger than a grain of rice. Synovial chondromatosis most commonly occurs in adults ages 20 to 50. Signs and symptoms may include pain, swelling, a decreased range of motion, and locking of the joint. The exact underlying cause of the condition is unknown. Treatment may involve surgery to remove the tumor. Recurrence of the condition is common.

MalaCards based summary : Synovial Chondromatosis, also known as synovial osteochondromatosis, is related to exostosis and osteochondroma, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Synovial Chondromatosis is ACVR2A (Activin A Receptor Type 2A), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. Affiliated tissues include endothelial, and related phenotypes are cellular and cardiovascular system

Wikipedia : 73 Synovial chondromatosis is a disease affecting the synovium, a thin flexible membrane around a... more...

Related Diseases for Synovial Chondromatosis

Diseases related to Synovial Chondromatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 exostosis 30.6 FN1 COL2A1 BMP2
2 osteochondroma 30.4 FGFR3 FGFR1 FGF9 FGF2 BMP2
3 myositis ossificans 30.4 COL1A1 BMP4
4 chondrosarcoma 30.3 SOX9 RUNX2 FGFR3 FGF2 BMP2
5 bone resorption disease 29.9 RUNX2 COL1A1 BMP2
6 fibrodysplasia ossificans progressiva 29.9 NOG BMP4 BMP2 ACVR2A
7 skeletal dysplasias 29.7 SOX9 FGFR3 COL2A1
8 pulmonary fibrosis, idiopathic 29.6 TGFB3 FN1 FGF2 COL1A1
9 stickler syndrome 29.6 SOX9 COL2A1 COL1A1 BMP4
10 osteoporosis 28.9 RUNX2 NOG FGF2 COL2A1 COL1A1 BMP4
11 synovial chondromatosis, familial, with dwarfism 11.4
12 plica syndrome 10.6
13 synovitis 10.6
14 arthropathy 10.6
15 villonodular synovitis 10.4
16 frozen shoulder 10.4
17 pigmented villonodular synovitis 10.4
18 bursitis 10.4
19 chondroma 10.3
20 radiculopathy 10.3
21 dyssegmental dysplasia, silverman-handmaker type 10.3 COL2A1 BMP2
22 dental pulp necrosis 10.3 FGF2 BMP2
23 rheumatoid arthritis 10.2
24 osteogenic sarcoma 10.2
25 osteoarthritis 10.2
26 arthritis 10.2
27 avascular necrosis 10.2
28 fgfr craniosynostosis syndromes 10.2 FGFR3 FGFR1
29 spondylometaphyseal dysplasia, corner fracture type 10.2 FN1 COL2A1
30 plagiocephaly 10.2 FGFR3 FGFR1
31 tympanosclerosis 10.2 COL2A1 COL1A1 BMP2
32 hypertelorism, microtia, facial clefting syndrome 10.2 FGFR3 FGFR1
33 gingival recession 10.2 FN1 BMP2
34 vitreous detachment 10.2 FN1 COL2A1
35 pseudopterygium 10.2 FGFR1 FGF2
36 tendinitis 10.1
37 calcific tendinitis 10.1
38 retinal perforation 10.1 FN1 COL2A1
39 sarcoma, synovial 10.1
40 chondrocalcinosis 10.1
41 gout 10.1
42 hyperostosis 10.1
43 hemangioma 10.1
44 synovium cancer 10.1
45 juxtacortical osteosarcoma 10.1
46 holzgreve syndrome 10.1 GLI3 FN1
47 rhinosporidiosis 10.1 FN1 BMP2
48 synostoses, tarsal, carpal, and digital 10.1 NOG FGF9
49 parasitic ichthyosporea infectious disease 10.1 FN1 BMP2
50 renal hypodysplasia/aplasia 3 10.1 FGFR3 BMP4

Graphical network of the top 20 diseases related to Synovial Chondromatosis:



Diseases related to Synovial Chondromatosis

Symptoms & Phenotypes for Synovial Chondromatosis

UMLS symptoms related to Synovial Chondromatosis:


arthralgia; metatarsalgia

MGI Mouse Phenotypes related to Synovial Chondromatosis:

46 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.48 ACVR2A BMP2 BMP4 COL1A1 COL2A1 FGF2
2 cardiovascular system MP:0005385 10.46 ACVR2A BMP2 BMP4 COL1A1 COL2A1 FGF2
3 craniofacial MP:0005382 10.44 ACVR2A BMP2 BMP4 COL1A1 COL2A1 FGF9
4 growth/size/body region MP:0005378 10.41 ACVR2A BMP2 BMP4 COL1A1 COL2A1 FGF9
5 homeostasis/metabolism MP:0005376 10.41 ACVR2A BMP2 BMP4 COL1A1 COL2A1 FGF2
6 digestive/alimentary MP:0005381 10.4 ACVR2A BMP2 BMP4 COL1A1 COL2A1 FGF9
7 embryo MP:0005380 10.36 ACVR2A BMP2 BMP4 COL1A1 COL2A1 FGF9
8 mortality/aging MP:0010768 10.35 ACVR2A BMP2 BMP4 COL1A1 COL2A1 FGF2
9 hematopoietic system MP:0005397 10.33 ACVR2A BMP2 BMP4 COL1A1 FGF2 FGF9
10 limbs/digits/tail MP:0005371 10.31 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
11 hearing/vestibular/ear MP:0005377 10.3 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9
12 nervous system MP:0003631 10.28 ACVR2A BMP2 BMP4 COL1A1 COL2A1 FGF2
13 integument MP:0010771 10.25 ACVR2A BMP4 COL1A1 FGF9 FGFR1 FGFR3
14 endocrine/exocrine gland MP:0005379 10.23 ACVR2A BMP4 COL1A1 FGF9 FGFR1 GLI3
15 immune system MP:0005387 10.22 ACVR2A BMP2 COL1A1 COL2A1 FGFR1 FGFR3
16 normal MP:0002873 10.15 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
17 muscle MP:0005369 10.11 BMP4 COL1A1 FGF2 FGF9 FGFR1 FN1
18 reproductive system MP:0005389 10.07 ACVR2A BMP2 BMP4 COL1A1 FGF2 FGF9
19 renal/urinary system MP:0005367 9.97 BMP4 COL1A1 COL2A1 FGF9 FGFR1 FGFR3
20 no phenotypic analysis MP:0003012 9.95 BMP4 COL1A1 FGFR1 FGFR3 GLI3 RUNX2
21 respiratory system MP:0005388 9.9 ACVR2A BMP4 COL1A1 COL2A1 FGF9 FGFR3
22 skeleton MP:0005390 9.83 ACVR2A BMP2 BMP4 COL1A1 COL2A1 FGF2
23 vision/eye MP:0005391 9.44 ACVR2A BMP4 COL1A1 COL2A1 FGF2 FGF9

Drugs & Therapeutics for Synovial Chondromatosis

Search Clinical Trials , NIH Clinical Center for Synovial Chondromatosis

Genetic Tests for Synovial Chondromatosis

Anatomical Context for Synovial Chondromatosis

MalaCards organs/tissues related to Synovial Chondromatosis:

40
Endothelial

Publications for Synovial Chondromatosis

Articles related to Synovial Chondromatosis:

(show top 50) (show all 1156)
# Title Authors PMID Year
1
Tumours and tumour-like lesions of joints: Differential diagnoses in a paediatric population compared to adults. 61
33617297 2021
2
Computed tomographic features of synovial chondromatosis of the temporomandibular joint with a few small calcified loose bodies. 61
32303973 2021
3
Synovial Chondromatosis of the knee: three different image methods. 61
33711104 2021
4
Tenosynovial chondromatosis of the flexor pollicis longus tendon: A subtype of primary synovial chondromatosis. 61
33363688 2021
5
Synovial chondromatosis of the temporomandibular joint with 400 loose bodies: a case report and literature review. 61
33752510 2021
6
An Unusual Cause of Limping in a 2-Year-Old Girl: Synovial Chondromatosis of the Knee. 61
32541346 2021
7
Imaging features of synovial chondromatosis of the temporomandibular joint: a report of 34 cases. 61
33762137 2021
8
Recurrent Synovial Chondromatosis of the Finger. 61
33561871 2021
9
Synovial Osteochondromatosis of the Knee. 61
33582024 2021
10
A Recurrent Synovial Osteochondromatosis of the Knee: A Case Report. 61
33603497 2021
11
Retrospective analysis of the clinical and radiological profile of few cases of synovial osteochondromatosis with a literature review. 61
33226330 2021
12
Synovial Chondromatosis of the Shoulder Causing Nerve Compression. 61
31651635 2020
13
Primary Intra-articular and Extra-articular Synovial Chondromatosis in a Child: A Rare Cause of Shoulder Pain in Children. 61
33397067 2020
14
[Expression of cartilage oligomeric matrix protein in the synovial chondromatosis of the temporomandibular joint]. 61
33550333 2020
15
Synovial chondromatosis of the temporomandibular joint: condyle osteotomy of the mandible and patient-specific fixation implant. 61
32811720 2020
16
Alloplastic Total Temporomandibular Joint Reconstruction: A 10-Year Experience of the University of the Witwatersrand, Johannesburg. 61
33201066 2020
17
[Tumors affecting the temporomandibular joint - a literature review]. 61
33059872 2020
18
Giant Extra-Articular Synovial Chondromatosis of the Ankle Joint - A Rare Case Report. 61
33708710 2020
19
Anterior and Posterior Arthroscopic Treatment of Primary Synovial Chondromatosis of the Ankle. 61
33203258 2020
20
The Foot, An Unusual Localization for Synovial Chondromatosis. 61
31415475 2020
21
Synovial chondromatosis of the temporomandibular joint: a case report. 61
32588651 2020
22
A Multidisciplinary Approach to Synovial Chondromatosis of the Temporomandibular Joint With Cranial Base Involvement: A Brief Review of the Literature and Case Report. 61
32544471 2020
23
Arthroscopic treatment of synovial chondromatosis of hip joint. 61
32917234 2020
24
Arthroscopic Treatment of Primary Synovial Chondromatosis of the Ankle: A Case Report and Review of Literature. 61
33489970 2020
25
Surgical treatment of a rare bilateral synovial chondromatosis. 61
33344313 2020
26
Arthroscopic Management of Synovial Chondromatosis of the Ankle Joint: A Systematic Review of the Literature. 61
33151646 2020
27
Synovial chondrosarcoma: a single-institution experience with molecular investigations and review of the literature. 61
32506447 2020
28
A Highly Unusual Clinical Presentation and Imaging Appearance of a Rare Diseases: Melorheostosis. 61
33489974 2020
29
Intraarticular Nodular Fasciitis of the Knee With MHY9-USP6 Fusion: A Case Report. 61
32089028 2020
30
Secondary Extra-Articular Synovial Osteochondromatosis with Involvement of the Leg, Ankle and Foot. An Exceptional Case. 61
32798176 2020
31
Synovial chondromatosis of ankle in a child: A rare presentation. 61
32675459 2020
32
Synovial Chondromatosis of the Temporomandibular Joint. 61
32346232 2020
33
Bilateral synovial chondromatosis of the elbow in an adolescent: a case report and literature review. 61
32534572 2020
34
A Rare Benign Tumor With Diagnostic Difficulties: Synovial Chondromatosis. 61
32851378 2020
35
Efficacy of image-guided synovial biopsy. 61
31912178 2020
36
Shoulder Tumor/Tumor-Like Lesions: What to Look for. 61
32241665 2020
37
Delayed-onset progressive pseudorheumatoid dysplasia with secondary synovial chondromatosis. 61
32430353 2020
38
Ankle synovial chondromatosis in anterior and posterior compartments. A Case report. 61
32555108 2020
39
Extra-articular synovial chondromatosis of the ankle: Unusual case with radiologic-pathologic correlation. 61
32123550 2020
40
Synovial chondromatosis of ankle in a child: A rare presentation. 61
32270781 2020
41
Intraligamentous synovial chondromatosis of the anterior cruciate ligament. 61
31760459 2020
42
Calcium pyrophosphate deposition disease: A case report with bilateral involvement of the temporomandibular joints and concurrence of psoriatic arthritis. 61
32274026 2020
43
Soft Tissue Special Issue: Chondroid Neoplasms of the Skull. 61
31950468 2020
44
A molecular study of synovial chondromatosis. 61
31589790 2020
45
Tumefactive synovial thickening mimicking synovial chondromatosis in the setting of oligoarticular juvenile idiopathic arthritis in a toddler. 61
31890072 2020
46
Pediatric primary synovial chondromatosis of the shoulder, biceps tendon sheath and subcoracoid bursa. 61
32099303 2020
47
Clinical Results of Surgical Resection and Histopathological Evaluation of Synovial Chondromatosis in the Shoulder: A Retrospective Study and Literature Review. 61
32117541 2020
48
Clinical Outcomes after Arthroscopic Treatment of Synovial Chondromatosis in the Hip. 61
32192367 2020
49
[Synovial chondromatosis of the knee. A rare cause of knee pain in pediatric age]. 61
31984706 2020
50
Synovial chondromatosis of suprapatellar bursa in a case of rheumatoid arthritis. 61
32914045 2020

Variations for Synovial Chondromatosis

Expression for Synovial Chondromatosis

Search GEO for disease gene expression data for Synovial Chondromatosis.

Pathways for Synovial Chondromatosis

Pathways related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 SOX9 NOG GLI3 FN1 FGFR3 FGFR1
2
Show member pathways
13.75 TGFB3 SOX9 FN1 FGFR3 FGFR1 FGF2
3
Show member pathways
13.63 TGFB3 FGFR3 FGFR1 FGF9 FGF2 BMP4
4
Show member pathways
13.48 TGFB3 FGFR3 FGFR1 FGF9 FGF2 BMP4
5
Show member pathways
13.35 TGFB3 FGFR3 FGFR1 FGF2 BMP4 BMP2
6
Show member pathways
13.27 TGFB3 FGFR3 FGFR1 FGF2 BMP4 BMP2
7
Show member pathways
13.25 TGFB3 FGFR3 FGFR1 FGF2 BMP4 BMP2
8
Show member pathways
13.22 TGFB3 FGFR3 FGFR1 FGF2 BMP4 BMP2
9
Show member pathways
13 TGFB3 FGFR3 FGFR1 FGF2 BMP4 BMP2
10
Show member pathways
12.95 TGFB3 FN1 FGFR3 FGFR1 FGF2 COL2A1
11
Show member pathways
12.93 FN1 FGFR3 FGFR1 FGF9 FGF2 COL2A1
12 12.72 TGFB3 FGFR3 FGFR1 FGF9 FGF2
13
Show member pathways
12.66 TGFB3 FGFR3 FGFR1 FGF2 BMP4 BMP2
14
Show member pathways
12.65 TGFB3 FN1 FGF2 COL2A1 COL1A1 BMP4
15 12.59 FN1 FGFR3 FGFR1 FGF9 FGF2
16 12.53 TGFB3 GLI3 FN1 FGFR3 FGFR1 FGF9
17
Show member pathways
12.52 FGFR3 FGFR1 FGF9 FGF2
18
Show member pathways
12.48 NOG FGFR1 BMP4 ACVR2A
19
Show member pathways
12.4 TGFB3 NOG FGF2 BMP4 BMP2 ACVR2A
20
Show member pathways
12.38 FGFR3 FGFR1 FGF9 FGF2
21
Show member pathways
12.37 FGFR3 FGFR1 FGF9 FGF2
22
Show member pathways
12.37 FGFR3 FGFR1 FGF9 FGF2
23 12.36 FGFR3 FGFR1 FGF9 FGF2
24
Show member pathways
12.36 TGFB3 FGFR3 FGFR1 FGF2 BMP4 BMP2
25 12.28 FN1 FGFR1 FGF2 COL1A1
26
Show member pathways
12.24 FGFR3 FGFR1 FGF9 FGF2
27
Show member pathways
12.22 TGFB3 FGFR3 FGFR1 FGF2 BMP4 BMP2
28
Show member pathways
12.13 FGFR3 FGFR1 FGF9 FGF2
29 12.06 FGFR3 FGFR1 FGF2 BMP4 ACVR2A
30 12.04 SOX9 NOG FGF2 BMP4
31 11.91 FN1 COL1A1 BMP2
32 11.89 TGFB3 FN1 COL1A1
33 11.87 TGFB3 FN1 COL1A1
34 11.85 TGFB3 RUNX2 GLI3
35 11.85 SOX9 FGFR3 FGFR1 FGF2 COL2A1 BMP4
36 11.84 TGFB3 FGFR3 FGFR1 FGF2
37
Show member pathways
11.82 FGFR1 FGF9 FGF2
38 11.8 TGFB3 NOG BMP4 BMP2 ACVR2A
39
Show member pathways
11.73 RUNX2 NOG BMP2 ACVR2A
40
Show member pathways
11.72 TGFB3 BMP4 BMP2
41 11.66 TGFB3 FGFR3 FGFR1 FGF2 BMP4 BMP2
42 11.63 FN1 COL2A1 COL1A1
43 11.63 SOX9 FGFR3 FGFR1 FGF2 BMP4 BMP2
44 11.61 RUNX2 NOG BMP4
45
Show member pathways
11.61 FGFR3 FGF9 FGF2
46 11.55 NOG FGF2 BMP4
47 11.51 FN1 FGFR1 FGF2
48 11.51 TGFB3 NOG FGF2 BMP4
49 11.44 FGFR3 FGFR1 FGF2
50 11.31 SOX9 RUNX2 GLI3 FGFR3 FGFR1 FGF2

GO Terms for Synovial Chondromatosis

Cellular components related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.62 TGFB3 FN1 COL2A1 COL1A1
2 extracellular space GO:0005615 9.61 TGFB3 NOG FN1 FGF9 FGF2 COL2A1
3 endoplasmic reticulum lumen GO:0005788 9.46 FN1 COL2A1 COL1A1 BMP4
4 basement membrane GO:0005604 9.43 FN1 FGF9 COL2A1
5 extracellular region GO:0005576 9.36 TGFB3 NOG FN1 FGFR3 FGFR1 FGF9

Biological processes related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.26 NOG FGFR3 FGFR1 FGF9 FGF2 BMP4
2 cell differentiation GO:0030154 10.23 SOX9 RUNX2 NOG FGF9 FGF2 BMP4
3 positive regulation of transcription by RNA polymerase II GO:0045944 10.22 TGFB3 SOX9 RUNX2 NOG GLI3 FGF2
4 negative regulation of transcription, DNA-templated GO:0045892 10.16 SOX9 RUNX2 GLI3 BMP4 BMP2
5 positive regulation of transcription, DNA-templated GO:0045893 10.16 TGFB3 SOX9 RUNX2 GLI3 FGF2 COL1A1
6 negative regulation of cell proliferation GO:0008285 10.13 TGFB3 SOX9 GLI3 BMP4 BMP2
7 regulation of gene expression GO:0010468 10.1 SOX9 RUNX2 GLI3 COL2A1 BMP4
8 positive regulation of gene expression GO:0010628 10.1 SOX9 RUNX2 NOG FN1 FGF9 FGF2
9 negative regulation of gene expression GO:0010629 10.09 SOX9 NOG FGF2 BMP4 BMP2
10 extracellular matrix organization GO:0030198 10.08 SOX9 FN1 FGF2 COL2A1 COL1A1
11 heart development GO:0007507 10.07 SOX9 GLI3 FN1 BMP4 BMP2
12 MAPK cascade GO:0000165 10.06 FGFR3 FGFR1 FGF9 FGF2
13 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.04 FGFR3 FGF2 BMP4 BMP2
14 in utero embryonic development GO:0001701 10.04 TGFB3 NOG GLI3 BMP2
15 positive regulation of protein kinase B signaling GO:0051897 10.03 FGFR3 FGFR1 FGF9 FGF2
16 negative regulation of canonical Wnt signaling pathway GO:0090090 10.03 SOX9 NOG GLI3 BMP2
17 positive regulation of protein phosphorylation GO:0001934 10.02 SOX9 FGF9 FGF2 BMP4 BMP2 ACVR2A
18 central nervous system development GO:0007417 10.01 SOX9 NOG GLI3 COL2A1
19 positive regulation of MAPK cascade GO:0043410 10.01 FGFR3 FGFR1 FGF9 FGF2 BMP2
20 lung development GO:0030324 9.98 GLI3 FGF9 FGF2 BMP4
21 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.98 SOX9 FN1 FGFR1 FGF2
22 osteoblast differentiation GO:0001649 9.97 RUNX2 NOG COL1A1 BMP4 BMP2
23 activation of MAPK activity GO:0000187 9.95 TGFB3 FGF2 BMP2
24 male gonad development GO:0008584 9.95 SOX9 FGF9 ACVR2A
25 fibroblast growth factor receptor signaling pathway GO:0008543 9.95 FGFR3 FGFR1 FGF9 FGF2
26 odontogenesis of dentin-containing tooth GO:0042475 9.95 RUNX2 GLI3 BMP4 BMP2
27 positive regulation of neuron differentiation GO:0045666 9.94 FGFR1 BMP4 BMP2
28 inner ear development GO:0048839 9.94 TGFB3 GLI3 COL2A1 BMP2
29 positive regulation of endothelial cell proliferation GO:0001938 9.93 FGF2 BMP4 BMP2
30 cell fate commitment GO:0045165 9.93 SOX9 BMP4 BMP2
31 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.93 TGFB3 BMP4 BMP2 ACVR2A
32 positive regulation of epithelial to mesenchymal transition GO:0010718 9.93 TGFB3 COL1A1 BMP4 BMP2
33 cartilage development GO:0051216 9.93 SOX9 NOG COL2A1 BMP4 BMP2
34 cellular response to growth factor stimulus GO:0071363 9.92 BMP4 BMP2 ACVR2A
35 SMAD protein signal transduction GO:0060395 9.92 TGFB3 BMP4 BMP2
36 epithelial to mesenchymal transition GO:0001837 9.92 SOX9 NOG FGFR1 BMP2
37 skeletal system morphogenesis GO:0048705 9.92 RUNX2 FGFR1 COL2A1 COL1A1
38 positive regulation of osteoblast differentiation GO:0045669 9.92 RUNX2 GLI3 BMP4 BMP2 ACVR2A
39 somatic stem cell population maintenance GO:0035019 9.91 SOX9 NOG FGF2
40 embryonic digit morphogenesis GO:0042733 9.91 NOG GLI3 BMP4
41 embryonic skeletal system development GO:0048706 9.91 NOG COL1A1 BMP4 ACVR2A
42 positive regulation of epithelial cell proliferation GO:0050679 9.91 SOX9 NOG FGF9 FGF2 BMP4
43 ossification GO:0001503 9.91 SOX9 RUNX2 COL2A1 COL1A1 BMP4 BMP2
44 positive regulation of cell proliferation GO:0008284 9.91 TGFB3 SOX9 RUNX2 FN1 FGFR3 FGFR1
45 positive regulation of cell division GO:0051781 9.9 TGFB3 FGF9 FGF2
46 positive regulation of cell differentiation GO:0045597 9.9 FGFR1 BMP4 BMP2
47 positive regulation of bone mineralization GO:0030501 9.9 TGFB3 BMP4 BMP2 ACVR2A
48 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.89 FGF2 BMP4 BMP2
49 protein localization to nucleus GO:0034504 9.88 SOX9 COL1A1 BMP4
50 regulation of cell differentiation GO:0045595 9.88 SOX9 RUNX2 GLI3 FGFR1 BMP4

Molecular functions related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.91 TGFB3 FN1 FGFR3 FGFR1 FGF2 COL2A1
2 extracellular matrix structural constituent GO:0005201 9.67 FN1 COL2A1 COL1A1
3 cytokine activity GO:0005125 9.62 TGFB3 FGF2 BMP4 BMP2
4 proteoglycan binding GO:0043394 9.48 FN1 COL2A1
5 BMP receptor binding GO:0070700 9.46 BMP4 BMP2
6 co-receptor binding GO:0039706 9.43 BMP4 BMP2
7 platelet-derived growth factor binding GO:0048407 9.4 COL2A1 COL1A1
8 heparin binding GO:0008201 9.35 FN1 FGFR1 FGF9 FGF2 BMP4
9 fibroblast growth factor-activated receptor activity GO:0005007 9.26 FGFR3 FGFR1
10 receptor-receptor interaction GO:0090722 9.16 FGFR1 FGF2
11 growth factor activity GO:0008083 9.02 TGFB3 FGF9 FGF2 BMP4 BMP2

Sources for Synovial Chondromatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....