MCID: SYN031
MIFTS: 47

Synovial Chondromatosis

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Synovial Chondromatosis

MalaCards integrated aliases for Synovial Chondromatosis:

Name: Synovial Chondromatosis 53
Synovial Osteochondromatosis 53 73
Chondromatosis, Synovial 73

Classifications:



External Ids:

Summaries for Synovial Chondromatosis

NIH Rare Diseases : 53 Synovial chondromatosis is a type of non-cancerous tumor that arises in the lining of a joint. The knee is most commonly affected, however it can affect any joint. The tumors begin as small nodules of cartilage. These nodules can separate and become loose within the joint. Some tumors may be no larger than a grain of rice. Synovial chondromatosis most commonly occurs in adults ages 20 to 50. Signs and symptoms may include pain, swelling, a decreased range of motion, and locking of the joint. The exact underlying cause of the condition is unknown. Treatment may involve surgery to remove the tumor. Recurrence of the condition is common.

MalaCards based summary : Synovial Chondromatosis, also known as synovial osteochondromatosis, is related to osteochondroma and osteoporosis, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Synovial Chondromatosis is NOG (Noggin), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Affiliated tissues include bone and endothelial, and related phenotypes are cellular and cardiovascular system

Wikipedia : 76 Synovial chondromatosis (synonyms include synovial osteochondromatosis, primary synovial... more...

Related Diseases for Synovial Chondromatosis

Diseases related to Synovial Chondromatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 osteochondroma 28.7 BMP2 FGF2 FGF9 FGFR1 FGFR3
2 osteoporosis 27.8 BMP2 BMP4 COL1A1 COL2A1 NOG RUNX2
3 synovial chondromatosis, familial, with dwarfism 12.2
4 chondrosarcoma 10.6
5 plagiocephaly 10.4 FGFR1 FGFR3
6 osteoglophonic dysplasia 10.4 FGFR1 FGFR3
7 chromosome 2q35 duplication syndrome 10.3 FGFR3 GLI3 NOG
8 chondroblastoma 10.3 FGFR1 FGFR3 SOX9
9 osteoarthritis 10.3
10 villonodular synovitis 10.3
11 synovitis 10.3
12 renal hypodysplasia/aplasia 3 10.2 BMP4 FGFR3
13 achondroplasia 10.2 FGFR1 FGFR3 SOX9
14 cervicitis 10.2
15 osteogenesis imperfecta, type ii 10.2 COL1A1 FGFR3 SOX9
16 sclerosteosis 10.2 COL1A1 NOG RUNX2
17 pigmented villonodular synovitis 10.1
18 bursitis 10.1
19 skeletal dysplasias 10.1 COL2A1 FGFR3 SOX9
20 bone deterioration disease 10.1 BMP2 COL2A1 SOX9
21 saethre-chotzen syndrome 10.1 FGFR1 FGFR3 RUNX2
22 pilomyxoid astrocytoma 10.1 COL1A1 COL2A1
23 bone resorption disease 10.1 BMP2 COL1A1 RUNX2
24 polydactyly, postaxial, type a1 10.1 BMP4 GLI3
25 hemangioma 10.1
26 rheumatoid arthritis 10.1
27 radiculopathy 10.1
28 arthritis 10.1
29 bone structure disease 10.0 BMP2 COL2A1 SOX9
30 jackson-weiss syndrome 10.0 FGFR1 FGFR3
31 ossification of the posterior longitudinal ligament of spine 10.0 BMP2 BMP4 RUNX2
32 ischemic bone disease 10.0 BMP2 COL2A1 RUNX2
33 holoprosencephaly 10.0 FGFR1 GLI3 NOG
34 synostosis 10.0 FGFR1 FGFR3 GLI3 NOG
35 crouzon syndrome 10.0 FGF2 FGFR1 FGFR3
36 osteochondrodysplasia 10.0 COL2A1 FGFR3 SOX9
37 tympanosclerosis 9.9 BMP2 COL1A1 COL2A1
38 tenosynovitis 9.9
39 sarcoma 9.9
40 dwarfism 9.9
41 osteopoikilosis 9.9
42 mycobacterium marinum 9.9
43 tarsal tunnel syndrome 9.9
44 relapsing polychondritis 9.9
45 endotheliitis 9.9
46 familial calcium pyrophosphate deposition 9.9
47 chondroma 9.9
48 fibrodysplasia ossificans progressiva 9.9
49 systemic lupus erythematosus 9.9
50 pleomorphic adenoma 9.9

Graphical network of the top 20 diseases related to Synovial Chondromatosis:



Diseases related to Synovial Chondromatosis

Symptoms & Phenotypes for Synovial Chondromatosis

UMLS symptoms related to Synovial Chondromatosis:


arthralgia, metatarsalgia

MGI Mouse Phenotypes related to Synovial Chondromatosis:

46 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.42 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9
2 cardiovascular system MP:0005385 10.39 FGF2 FGF9 FGFR1 GLI3 NOG RUNX2
3 craniofacial MP:0005382 10.38 GLI3 NOG RUNX2 SOX9 TGFB3 BMP2
4 digestive/alimentary MP:0005381 10.37 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
5 growth/size/body region MP:0005378 10.35 TGFB3 BMP2 BMP4 COL1A1 COL2A1 FGF9
6 homeostasis/metabolism MP:0005376 10.35 COL2A1 FGF2 FGF9 FGFR1 FGFR3 GLI3
7 hearing/vestibular/ear MP:0005377 10.3 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9
8 mortality/aging MP:0010768 10.29 FGFR1 FGFR3 GLI3 NOG RUNX2 SOX9
9 embryo MP:0005380 10.28 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
10 behavior/neurological MP:0005386 10.27 SOX9 TGFB3 BMP4 COL1A1 COL2A1 FGF2
11 limbs/digits/tail MP:0005371 10.27 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
12 nervous system MP:0003631 10.21 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGFR1
13 hematopoietic system MP:0005397 10.2 BMP2 BMP4 COL1A1 FGF2 FGFR1 FGFR3
14 endocrine/exocrine gland MP:0005379 10.18 BMP4 COL1A1 FGF9 FGFR1 GLI3 NOG
15 immune system MP:0005387 10.18 BMP2 COL1A1 COL2A1 FGF9 FGFR1 FGFR3
16 integument MP:0010771 10.16 BMP4 COL1A1 FGF9 FGFR1 FGFR3 GLI3
17 normal MP:0002873 10.11 BMP2 BMP4 COL1A1 COL2A1 FGF9 FGFR1
18 muscle MP:0005369 10.06 BMP4 COL1A1 FGF2 FGF9 FGFR1 NOG
19 reproductive system MP:0005389 10 BMP2 BMP4 COL1A1 FGF2 FGF9 FGFR1
20 no phenotypic analysis MP:0003012 9.95 FGFR3 GLI3 RUNX2 SOX9 BMP4 COL1A1
21 renal/urinary system MP:0005367 9.92 BMP4 COL1A1 COL2A1 FGFR1 FGFR3 GLI3
22 respiratory system MP:0005388 9.85 FGFR3 GLI3 NOG RUNX2 SOX9 TGFB3
23 skeleton MP:0005390 9.77 NOG RUNX2 SOX9 TGFB3 BMP2 BMP4
24 vision/eye MP:0005391 9.4 COL1A1 COL2A1 FGF2 FGF9 FGFR1 FGFR3

Drugs & Therapeutics for Synovial Chondromatosis

Search Clinical Trials , NIH Clinical Center for Synovial Chondromatosis

Genetic Tests for Synovial Chondromatosis

Anatomical Context for Synovial Chondromatosis

MalaCards organs/tissues related to Synovial Chondromatosis:

41
Bone, Endothelial

Publications for Synovial Chondromatosis

Articles related to Synovial Chondromatosis:

(show top 50) (show all 541)
# Title Authors Year
1
Atypical synovial chondromatosis of the right knee: A case report. ( 29725385 )
2018
2
Intra- and extracapsular synovial chondromatosis of the temporomandibular joint: Rare case and review of the literature. ( 29796269 )
2018
3
Arthroscopic and Endoscopic Technique for Subcoracoid Synovial Chondromatosis of the Shoulder Through a Medial Transpectoral Portal. ( 29881701 )
2018
4
Huge Bursitis and Bursal Synovial Osteochondromatosis associated with Scapular Osteochondroma Mimicking a Giant Calcific Mass of the Chest Wall: A Case Report. ( 29905601 )
2018
5
Long-Term Outcome of Hip Arthroplasty in the Setting of Synovial Chondromatosis. ( 29550167 )
2018
6
Synovial Chondromatosis in Patient Presenting with Chronic Venous Stasis Ulcers. ( 29655813 )
2018
7
Surgical Treatment of Synovial Chondromatosis in the Inferior Compartment of the Temporomandibular Joint With Articular Disc Involvement. ( 29303858 )
2018
8
Ulnar nerve palsy caused by synovial protrusion in synovial chondromatosis of the elbow: a case report and literature review. ( 29560039 )
2018
9
Temporomandibular joint synovial chondromatosis accompanying temporal bone proliferation: A case report. ( 29963487 )
2018
10
Arthroscopic Management and Treatment of Synovial Chondromatosis and Talus Osteochondral Defect in the Ankle Joint. A Case Study. ( 29086752 )
2017
11
Synovial chondromatosis of the temporomandibular joint with intracranial extension-report of two cases. ( 28641900 )
2017
12
Arthroscopic Treatment of Synovial Chondromatosis in the Ankle Joint. ( 29503777 )
2017
13
Synovial osteochondromatosis in a 14-year-old boy with a history of Legg-Calve-Perthes disease. ( 28491198 )
2017
14
An unusual presentation of synovial chondromatosis of the knee in a 10-year-old girl. ( 28615116 )
2017
15
High Rate of Local Recurrence and Complications Following Total Knee Arthroplasty in the Setting of Synovial Chondromatosis. ( 28364965 )
2017
16
Temporomandibular joint synovial chondromatosis extending to the temporal bone: a report of two cases. ( 29142869 )
2017
17
Shoulder joint synovial chondromatosis presenting as multiple axillary masses: A case report. ( 29159809 )
2017
18
Primary synovial chondromatosis of the subtalar joint: case report and review of the literature. ( 28932921 )
2017
19
Bursal Synovial Chondromatosis Secondary to Underlying Osteochondroma in a Child. ( 29468100 )
2017
20
Malignant Transformation of Synovial Chondromatosis: A Systematic Review. ( 28694891 )
2017
21
Open surgery assisted with arthroscopy to treat synovial chondromatosis of the temporomandibular joint. ( 27769739 )
2017
22
Recurrent synovial chondromatosis of the temporomandibular joint: report of two cases. ( 28964665 )
2017
23
Synovial Chondromatosis ( 29262110 )
2017
24
Synovial chondromatosis of the temporomandibular joint with extension into the middle cranial fossa and internal carotid canal. ( 28314662 )
2017
25
A Case Report of Primary Synovial Chondromatosis with Bilateral Genu Valgum. ( 29242805 )
2017
26
Intermetatarsal bursa primary synovial chondromatosis: case report and review of the literature. ( 28914347 )
2017
27
Recurrent Extra- and Intra-articular Synovial Chondromatosis of the Ankle with Tarsal Tunnel Syndrome: A Rare Case Report. ( 28819605 )
2017
28
Reverse Total Shoulder Arthroplasty for the Treatment of Synovial Chondromatosis: A Case Report and Review of the Literature. ( 28497103 )
2017
29
Synovial Chondromatosis: A Rare Differential Diagnosis of Hip Pain in a Child. ( 28819599 )
2017
30
Synovial Chondromatosis of Dorsal Spine: Case Report of Rare Pathological Entity and Review. ( 28127377 )
2016
31
Patellar Subluxation With Early-Phase Synovial Chondromatosis of the Knee. ( 26726983 )
2016
32
Synovial chondromatosis involving multiple joints in rheumatoid arthritis: A case report review of the literature. ( 27126892 )
2016
33
Synovial chondromatosis of the right side temporomandibular joint extending to the middle cranial fossa: A case report with 7-year postoperative follow up and expression of a biomarker of cell proliferative activity. ( 26855075 )
2016
34
Synovial Chondromatosis of the Suprapatellar Pouch of the Knee in a Patient with Systemic Lupus Erythematosus. ( 27134266 )
2016
35
Innovative Surgical Management of the Synovial Chondromatosis of Temporo-Mandibular Joints: Highly Conservative Surgical Technique. ( 27300457 )
2016
36
SYNOVIAL CHONDROMATOSIS OF THE POSTERIOR COMPARTMENT OF THE KNEE: A Case Report & Literature Review Focusing on Arthroscopic Treatment. ( 27169166 )
2016
37
Uncommon Primary Synovial Chondromatosis Involving Only the Infrapatellar Fat Pad in an Elderly Patient. ( 26955617 )
2016
38
Glenohumeral Synovial Chondromatosis. ( 27581180 )
2016
39
Primary synovial chondromatosis: a reassessment of malignant potential in 155 cases. ( 26919862 )
2016
40
Primary synovial chondromatosis of the talonavicular joint: A case report. ( 27810034 )
2016
41
Unusual Extensive Synovial Chondromatosis of the Temporomandibular Joint. ( 27755443 )
2016
42
Solitary synovial chondromatosis arising in the gluteus maximus bursa: computed tomography and magnetic resonance imaging findings. ( 26998347 )
2016
43
Arthroscopic Retrieval of over 100 Loose Bodies in Shoulder Synovial Chondromatosis: A Case Report and Review of Literature. ( 28032713 )
2016
44
Synovial chondromatosis of the temporomandibular joint: Immunohistochemical examinations regarding the role of insulin-like growth factors and their binding proteins in the etiology of this disease. ( 28089088 )
2016
45
Synovial Chondromatosis of the Elbow With Asymptomatic Ulnar Nerve Compression. ( 27595934 )
2016
46
Relapsing Polychondritis Concomitant With Synovial Chondromatosis of the Temporomandibular Joint. ( 27292528 )
2016
47
Clinical and Imaging Findings of Temporomandibular Joint Synovial Chondromatosis: An Analysis of 10 Cases and Literature Review. ( 27238571 )
2016
48
Endoscopic Resection of the Lateral Ankle Bursa With Synovial Chondromatosis. ( 27656367 )
2016
49
Case Report of Mimicry between Synovial Hemangioma and Synovial Chondromatosis of the Shoulder. ( 28164062 )
2016
50
Giant synovial chondromatosis of the metacarpophalangeal joint. ( 26682941 )
2016

Variations for Synovial Chondromatosis

Expression for Synovial Chondromatosis

Search GEO for disease gene expression data for Synovial Chondromatosis.

Pathways for Synovial Chondromatosis

Pathways related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGFR1
2
Show member pathways
13.62 BMP2 BMP4 FGF2 FGF9 FGFR1 FGFR3
3
Show member pathways
13.4 BMP2 BMP4 FGF2 FGF9 FGFR1 FGFR3
4
Show member pathways
13.31 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
5
Show member pathways
13.23 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
6
Show member pathways
13.2 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
7
Show member pathways
13.18 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
8
Show member pathways
12.93 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
9
Show member pathways
12.84 COL1A1 COL2A1 FGF2 FGF9 FGFR1 FGFR3
10
Show member pathways
12.81 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGFR1
11
Show member pathways
12.68 FGF2 FGF9 FGFR1 FGFR3
12 12.68 FGF2 FGF9 FGFR1 FGFR3 TGFB3
13
Show member pathways
12.67 FGF2 FGF9 FGFR1 TGFB3
14
Show member pathways
12.64 FGF2 FGF9 FGFR1 FGFR3
15
Show member pathways
12.63 FGF2 FGF9 FGFR1 FGFR3
16
Show member pathways
12.59 BMP2 BMP4 COL1A1 COL2A1 FGF2 TGFB3
17 12.58 BMP2 BMP4 FGF2 FGF9 FGFR1 FGFR3
18 12.54 FGF2 FGF9 FGFR1 FGFR3
19
Show member pathways
12.53 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
20
Show member pathways
12.49 FGF2 FGF9 FGFR1 FGFR3
21
Show member pathways
12.37 FGF2 FGF9 FGFR1 FGFR3
22
Show member pathways
12.35 BMP2 BMP4 FGF2 NOG TGFB3
23
Show member pathways
12.34 FGF2 FGF9 FGFR1 FGFR3
24
Show member pathways
12.33 FGF2 FGF9 FGFR1 FGFR3
25
Show member pathways
12.19 FGF2 FGF9 FGFR1 FGFR3
26
Show member pathways
12.15 COL1A1 FGF2 FGFR1 FGFR3
27
Show member pathways
12.07 FGF2 FGF9 FGFR1 FGFR3
28 12.06 BMP2 BMP4 TGFB3
29
Show member pathways
12.05 BMP2 BMP4 GLI3
30 12.03 FGF2 FGFR1 FGFR3
31 12 BMP4 FGF2 FGFR1 FGFR3
32 11.97 BMP2 BMP4 TGFB3
33 11.97 BMP4 FGF2 NOG SOX9
34
Show member pathways
11.89 BMP2 BMP4 FGF2 FGFR1 FGFR3 TGFB3
35 11.83 GLI3 RUNX2 TGFB3
36
Show member pathways
11.8 FGF2 FGF9 FGFR1
37 11.75 FGF2 FGFR1 FGFR3 TGFB3
38 11.7 BMP2 BMP4 NOG TGFB3
39
Show member pathways
11.69 BMP2 BMP4 TGFB3
40
Show member pathways
11.67 BMP2 NOG RUNX2
41 11.64 BMP4 COL2A1 FGF2 FGFR1 FGFR3 SOX9
42
Show member pathways
11.57 FGF2 FGF9 FGFR3
43 11.57 BMP4 NOG RUNX2
44 11.52 BMP4 FGF2 NOG
45 11.38 FGF2 FGFR1 FGFR3
46 11.35 BMP4 FGF2 NOG TGFB3
47 11.33 BMP2 BMP4 FGF2 FGFR1 FGFR3 SOX9
48 11.12 FGF2 FGFR1 TGFB3
49 11.11 BMP2 BMP4
50 11.04 BMP2 BMP4

GO Terms for Synovial Chondromatosis

Cellular components related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9
2 extracellular region GO:0005576 9.32 BMP2 BMP4 COL1A1 COL2A1 FGF2 FGF9

Biological processes related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phosphorylation GO:0046854 9.98 FGF2 FGF9 FGFR1 FGFR3
2 lung development GO:0030324 9.98 BMP4 FGF9 FGFR1 GLI3
3 positive regulation of protein phosphorylation GO:0001934 9.97 BMP2 BMP4 SOX9
4 sensory perception of sound GO:0007605 9.97 COL1A1 COL2A1 FGFR1
5 fibroblast growth factor receptor signaling pathway GO:0008543 9.97 FGF2 FGF9 FGFR1 FGFR3
6 central nervous system development GO:0007417 9.97 COL2A1 FGFR1 GLI3 NOG SOX9
7 activation of MAPK activity GO:0000187 9.96 BMP2 FGF2 TGFB3
8 positive regulation of neuron differentiation GO:0045666 9.95 BMP2 BMP4 FGFR1
9 roof of mouth development GO:0060021 9.95 COL2A1 GLI3 TGFB3
10 positive regulation of endothelial cell proliferation GO:0001938 9.94 BMP2 BMP4 FGF2
11 positive regulation of epithelial cell proliferation GO:0050679 9.94 BMP4 FGF9 NOG SOX9
12 cell fate commitment GO:0045165 9.93 BMP2 BMP4 SOX9
13 inner ear morphogenesis GO:0042472 9.93 COL2A1 FGF9 FGFR1
14 somatic stem cell population maintenance GO:0035019 9.93 FGF2 NOG SOX9
15 positive regulation of osteoblast differentiation GO:0045669 9.93 BMP2 BMP4 GLI3 RUNX2
16 BMP signaling pathway GO:0030509 9.93 BMP2 BMP4 NOG RUNX2 TGFB3
17 SMAD protein signal transduction GO:0060395 9.92 BMP2 BMP4 TGFB3
18 embryonic digit morphogenesis GO:0042733 9.92 BMP4 GLI3 NOG
19 cell development GO:0048468 9.92 BMP2 BMP4 TGFB3
20 regulation of MAPK cascade GO:0043408 9.92 BMP2 BMP4 TGFB3
21 odontogenesis of dentin-containing tooth GO:0042475 9.92 BMP2 BMP4 GLI3 RUNX2
22 wound healing GO:0042060 9.92 COL1A1 FGF2 GLI3 NOG TGFB3
23 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.91 BMP2 BMP4 TGFB3
24 embryonic limb morphogenesis GO:0030326 9.91 BMP4 FGF9 FGFR1 GLI3
25 inner ear development GO:0048839 9.91 BMP2 COL2A1 GLI3 TGFB3
26 cartilage development GO:0051216 9.91 BMP2 BMP4 COL2A1 NOG SOX9
27 positive regulation of cell division GO:0051781 9.9 FGF2 FGF9 TGFB3
28 ureteric bud development GO:0001657 9.9 BMP4 FGFR1 NOG
29 epithelial to mesenchymal transition GO:0001837 9.89 BMP2 NOG SOX9
30 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.89 FGF2 FGF9 FGFR1 FGFR3
31 positive regulation of cardiac muscle cell proliferation GO:0060045 9.88 FGF2 FGF9 FGFR1
32 positive regulation of bone mineralization GO:0030501 9.88 BMP2 BMP4 TGFB3
33 mammary gland development GO:0030879 9.88 GLI3 SOX9 TGFB3
34 positive regulation of epithelial to mesenchymal transition GO:0010718 9.88 BMP2 BMP4 COL1A1 TGFB3
35 skeletal system morphogenesis GO:0048705 9.88 COL1A1 COL2A1 FGFR1 RUNX2
36 protein localization to nucleus GO:0034504 9.87 BMP4 COL1A1 SOX9
37 face morphogenesis GO:0060325 9.87 COL1A1 NOG TGFB3
38 telencephalon development GO:0021537 9.86 BMP2 BMP4 GLI3
39 positive regulation of mesenchymal cell proliferation GO:0002053 9.86 FGF9 FGFR1 SOX9
40 anatomical structure formation involved in morphogenesis GO:0048646 9.86 BMP4 GLI3 NOG
41 embryonic skeletal system development GO:0048706 9.86 BMP4 COL1A1 FGF9 NOG
42 positive regulation of chondrocyte differentiation GO:0032332 9.85 GLI3 RUNX2 SOX9
43 osteoblast differentiation GO:0001649 9.85 BMP2 BMP4 COL1A1 FGF9 NOG RUNX2
44 endocardial cushion morphogenesis GO:0003203 9.84 BMP2 NOG SOX9
45 embryonic morphogenesis GO:0048598 9.83 BMP4 FGF2 GLI3
46 positive regulation of cartilage development GO:0061036 9.83 BMP2 BMP4 SOX9
47 branching involved in ureteric bud morphogenesis GO:0001658 9.83 BMP2 BMP4 FGF2 GLI3 SOX9
48 embryonic skeletal joint morphogenesis GO:0060272 9.81 BMP4 COL2A1 NOG
49 positive regulation of collagen biosynthetic process GO:0032967 9.8 BMP4 TGFB3
50 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.8 BMP2 BMP4

Molecular functions related to Synovial Chondromatosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.8 BMP2 BMP4 FGF2 TGFB3
2 protein tyrosine kinase activity GO:0004713 9.73 FGF2 FGF9 FGFR1 FGFR3
3 heparin binding GO:0008201 9.67 BMP4 FGF2 FGF9 FGFR1
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.62 FGF2 FGF9 FGFR1 FGFR3
5 transforming growth factor beta receptor binding GO:0005160 9.58 BMP2 BMP4 TGFB3
6 fibroblast growth factor receptor binding GO:0005104 9.56 FGF2 FGF9
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.56 FGF2 FGF9 FGFR1 FGFR3
8 bHLH transcription factor binding GO:0043425 9.55 RUNX2 SOX9
9 fibroblast growth factor binding GO:0017134 9.54 FGFR1 FGFR3
10 co-receptor binding GO:0039706 9.52 BMP2 BMP4
11 platelet-derived growth factor binding GO:0048407 9.51 COL1A1 COL2A1
12 fibroblast growth factor-activated receptor activity GO:0005007 9.48 FGFR1 FGFR3
13 receptor-receptor interaction GO:0090722 9.46 FGF2 FGFR1
14 growth factor activity GO:0008083 9.35 BMP2 BMP4 FGF2 FGF9 TGFB3
15 BMP receptor binding GO:0070700 9.33 BMP2 BMP4 TGFB3
16 1-phosphatidylinositol-3-kinase activity GO:0016303 8.92 FGF2 FGF9 FGFR1 FGFR3

Sources for Synovial Chondromatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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