Aliases & Classifications for Synovitis

MalaCards integrated aliases for Synovitis:

Name: Synovitis 12 77 54 30 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2703
MeSH 45 D013585
NCIt 51 C50766
SNOMED-CT 69 14107000
ICD10 34 M65.9
UMLS 74 C0039103

Summaries for Synovitis

Disease Ontology : 12 A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards based summary : Synovitis is related to noonan syndrome 1 and septic arthritis, and has symptoms including arthralgia, myalgia and metatarsalgia. An important gene associated with Synovitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Etanercept and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and b cells, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 77 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints that... more...

Related Diseases for Synovitis

Diseases related to Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 469)
# Related Disease Score Top Affiliating Genes
1 noonan syndrome 1 33.1 CXCL8 IL1B IL6 TNF
2 septic arthritis 31.0 CRP CXCL8 MMP3
3 temporal arteritis 30.4 CRP IL1RN IL6 TNF
4 reactive arthritis 30.4 COMP CRP TNF
5 palindromic rheumatism 30.3 CRP IL1B TNF
6 angioimmunoblastic lymphadenopathy with dysproteinemia 30.3 IL6 TNF
7 arthritis 30.3 CXCL8 IL18 IL1B IL1RN IL6 MMP1
8 osteoarthritis 30.2 COMP IL1B IL6 MMP1 MMP13 MMP3
9 osteomyelitis 30.2 CXCL8 IL1B IL1RN IL6 TNF TNFSF11
10 chikungunya 30.1 IL1B IL6 TNF
11 pertussis 30.1 IL1B IL6 TNF
12 spondylitis 30.1 CRP IL1RN IL6 TNF
13 bronchiolitis obliterans 30.1 CXCL8 IL6 TNF
14 familial mediterranean fever 30.0 CRP IL1B IL1RN TNF
15 spondyloarthropathy 1 29.9 CD163 CRP MMP3 TNF TNFRSF11B
16 fasciitis 29.8 CXCL8 IL18 IL6 TNF
17 hydrarthrosis 29.8 IL1B IL1RN MMP13 MMP3
18 bone resorption disease 29.8 IL6 TNFRSF11B TNFSF11
19 juvenile rheumatoid arthritis 29.8 CRP IL18 IL1B IL1RN IL6 TNF
20 hemophilic arthropathy 29.7 COMP TNFRSF11B TNFSF11
21 pneumonia 29.7 CRP CXCL8 IL1B IL6 TNF
22 relapsing polychondritis 29.7 COMP CRP IL6
23 lyme disease 29.6 CRP IL1B IL6 TNF
24 joint disorders 29.6 IL1B IL1RN IL6 MMP3 TNF TNFSF11
25 bronchiolitis 29.6 CRP CXCL8 IL6 TNF
26 lymphadenitis 29.6 CXCL8 ICAM1 IL18 IL1B TNF
27 pleurisy 29.5 CRP CXCL8 ICAM1 TNF
28 inflammatory bowel disease 29.5 CRP CXCL8 IL18 IL1B IL6 TNF
29 arthropathy 29.4 COMP CRP PRG4 TNF TNFRSF11B TNFSF11
30 brucellosis 29.3 CRP CXCL8 IL18 IL1RN IL6 TNF
31 rheumatic disease 29.2 CD163 CRP IL18 IL1B TNF TNFRSF11B
32 vasculitis 29.0 CRP ICAM1 SELE TNF VCAM1
33 chronic kidney failure 29.0 CRP ICAM1 IL6 TNFRSF11B VCAM1
34 kawasaki disease 29.0 CRP IL6 MMP3 SELE TNF
35 pericarditis 28.7 CRP IL1B IL1RN IL6 PRG4 TNF
36 psoriatic arthritis 28.6 COMP CRP IL1B IL6 MMP1 MMP3
37 systemic lupus erythematosus 28.6 CRP ICAM1 IL18 IL1B IL6 SELE
38 bone inflammation disease 28.3 COMP CRP CXCL8 IL1B IL1RN IL6
39 rheumatoid arthritis 27.9 COMP CRP CXCL8 ICAM1 IL18 IL1B
40 pigmented villonodular synovitis 12.7
41 villonodular synovitis 12.5
42 remitting seronegative symmetrical synovitis with pitting edema 12.4
43 talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals 12.2
44 gonococcal synovitis 12.2
45 sapho syndrome 12.1
46 legg-calve-perthes disease 11.4
47 intermittent hydrarthrosis 11.4
48 eosinophilic fasciitis 11.4
49 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 11.3
50 blau syndrome 11.2

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to Synovitis

Symptoms & Phenotypes for Synovitis

UMLS symptoms related to Synovitis:


arthralgia, myalgia, metatarsalgia

MGI Mouse Phenotypes related to Synovitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 CD163 COMP CRP ICAM1 IL18 IL1B
2 growth/size/body region MP:0005378 10.15 COMP ICAM1 IL18 IL1B IL1RN IL6
3 cellular MP:0005384 10.14 CD163 COMP ICAM1 IL18 IL1RN IL6
4 hematopoietic system MP:0005397 10.13 CD163 CD68 ICAM1 IL18 IL1B IL1RN
5 homeostasis/metabolism MP:0005376 10.13 CD163 COMP CRP ICAM1 IL18 IL1B
6 immune system MP:0005387 10.06 CD163 CD68 COMP CRP ICAM1 IL18
7 integument MP:0010771 9.61 ICAM1 IL18 IL1B IL1RN IL6 MMP13
8 skeleton MP:0005390 9.32 CD68 COMP IL1B IL1RN IL6 MMP13

Drugs & Therapeutics for Synovitis

Drugs for Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 202)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
2
leucovorin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 6006 143
3
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 302-25-0
4
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 50-24-8 5755
5
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 83-43-2 6741
7
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Early Phase 1 2921-57-5
8
Infliximab Approved Phase 4,Phase 2,Not Applicable 170277-31-3
9
Sulfasalazine Approved Phase 4,Not Applicable 599-79-1 5353980 5359476
10
Hydroxychloroquine Approved Phase 4,Phase 2,Not Applicable 118-42-3 3652
11
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
12
Tofacitinib Approved, Investigational Phase 4,Phase 3,Phase 2 477600-75-2
13
Abatacept Approved Phase 4,Phase 3,Phase 1,Phase 2 332348-12-6 10237
14
rituximab Approved Phase 4,Phase 3,Phase 2 174722-31-7 10201696
15
Liraglutide Approved Phase 4 204656-20-2 44147092
16
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
17
Apremilast Approved, Investigational Phase 4,Phase 2 608141-41-9 11561674
18
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
19 Ixekizumab Approved, Investigational Phase 4,Phase 3,Phase 2 1143503-69-8
20
Leflunomide Approved, Investigational Phase 4,Phase 3 75706-12-6 3899
21
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 59-30-3 6037
23
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Early Phase 1 2920-86-7
24 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
25 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
27 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
28 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
30 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
31 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Early Phase 1
32 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
33 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
34 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Not Applicable
35 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
36 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
37 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
39 Antiemetics Phase 4,Phase 3,Phase 2,Early Phase 1
40 Methylprednisolone Acetate Phase 4,Phase 3,Phase 2,Early Phase 1
41 Vitamin B9 Phase 4,Phase 3,Phase 2,Not Applicable
42 Analgesics Phase 4,Phase 3,Phase 2
43 Folate Phase 4,Phase 3,Phase 2,Not Applicable
44 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
45 Prednisolone acetate Phase 4,Phase 3,Phase 2,Early Phase 1
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
47 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
48 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
49 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
50 Vitamin B Complex Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 216)
# Name Status NCT ID Phase Drugs
1 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
2 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4 Etanercept, methotrexate and depomedrone;depemedrone
3 Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis Unknown status NCT01282528 Phase 4
4 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
5 Efficacy, Radiographic and Laboratory Changes in Refractory Rheumatoid Arthritis Patients Treated With H.P. Acthar Gel Unknown status NCT03082573 Phase 4 H.P. Acthar gel
6 A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs Completed NCT01034397 Phase 4 tocilizumab [RoActemra/Actemra];placebo;non-biological DMARDs
7 A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. Completed NCT00502853 Phase 4 rituximab [MabThera/Rituxan];Methotrexate
8 A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study Completed NCT00396747 Phase 4 Infliximab, methylprednisolone, methotrexate;Methotrexate;Methotrexate + Methylprednisolone;Methotrexate + Infliximab
9 The Effect of Corticotrophin (ACTH) in Combination With Methotrexate in Newly Diagnosed Rheumatoid Arthritis Patients Completed NCT01948388 Phase 4 corticotrophin 80 units
10 Musculoskeletal Ultrasound in Predicting Early Dose Titration With Tocilizumab Completed NCT01717859 Phase 4 Tocilizumab
11 Aiming for Remission in Rheumatoid Arthritis (RA) - the ARCTIC Trial Completed NCT01205854 Phase 4
12 A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects Completed NCT02198651 Phase 4 Adalimumab
13 Bone Mineral Density Changes Under Two Tibial Components in Total Knee Arthroplasty Completed NCT01764984 Phase 4
14 Prednisolone for Pain Reduction in Knee OA Completed NCT01619163 Phase 4 Placebo;Prednisolone
15 Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis Completed NCT00420927 Phase 4 methotrexate
16 Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance Completed NCT02928679 Phase 4 Liraglutide 3 mg (Saxenda);Liraglutide 3 mg placebo
17 Zushima Plaster for Treating Knee Osteoarthritis Completed NCT02770950 Phase 4 Zushima plaster with high dose;Zushima plaster with low dose;Indometacin Cataplasms
18 Musculoskeletal Ultrasound Assessment of Therapeutic Response of Tofacitinib in Rheumatoid Arthritis Patients Completed NCT02321930 Phase 4 tofacitinib 5mg po bid
19 Study Comparing The Effect On Disease Activity When Reducing Or Discontinuing Etanercept In Subjects With RA Completed NCT00858780 Phase 4 Etanercept;Etanercept;Placebo
20 A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA) Completed NCT01185288 Phase 4 Methotrexate
21 A Study to Evaluate the Impact of Apremilast (CC-10004) on MRI Outcomes in Subjects With Psoriatic Arthritis Recruiting NCT03783026 Phase 4 CC-10004
22 Clinical Impact of Acthar in the Psoriatic Arthritis Patient (CLIPS) Recruiting NCT03419650 Phase 4 ACTHar
23 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis Recruiting NCT02765074 Phase 4 subcutaneous tocilizumab
24 Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders Recruiting NCT03227419 Phase 4 Tocilizumab Prefilled Syringe;Abatacept Prefilled Syringe
25 Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis Active, not recruiting NCT02437461 Phase 4 Triamcinolone hexacetonide
26 A Study of Ixekizumab (LY2439821) Versus Adalimumab in Participants With Psoriatic Arthritis Active, not recruiting NCT03151551 Phase 4 Ixekizumab;Adalimumab
27 The Comparative Study of Intra-articular Injection of Tocilizumab and Compound Betamethasone Not yet recruiting NCT03215407 Phase 4 Intra-articular Tocilizumab;Intra-articular Compound Betamethasone
28 Psoriatic Oligoarthritis Intervention With Symptomatic thErapy Not yet recruiting NCT03797872 Phase 4 Methotrexate;Sulfasalazine;Leflunomide;Methylprednisolone;Triamcinolone
29 Targeted Treatment Early With Etanercept + Methotrexate vs.T2T Care for DMARD-naïve Early RA Patients Based on naïve T-cell Stratification Not yet recruiting NCT03813771 Phase 4 Benepali;Sulfasalazine;Methotrexate;Hydroxychloroquine
30 Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging Study Terminated NCT01659242 Phase 4 Methotrexate plus sulfasalazine;Leflunomide
31 A Study of Efficacy of Rituximab [Mabthera/Rituxan] in Patients With Rheumatoid Arthritis Using Magnetic Resonance Imaging of the Hand (RESONAR) Terminated NCT01117129 Phase 4 rituximab [MabThera/Rituxan];placebo;methotrexate;rituximab [Mabthera/Rituxan]
32 A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs Withdrawn NCT01878318 Phase 4 methotrexate;tocilizumab [RoActemra/Actemra]
33 Treatment With Apremilast in Patients With Psoriatic Arthritis Withdrawn NCT02558361 Phase 4 Treatment with Apremilast
34 Abatacept Reversing Subclinical Inflammation as Measured by MRI in ACPA Positive Arthralgia Unknown status NCT02778906 Phase 3 Abatacept;Placebo
35 An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective Unknown status NCT02566967 Phase 3 tofacitinib
36 Exploration of TNF-alpha Blockade With Golimumab in the Induction of Clinical Remission in Patients With Early Peripheral Spondyloarthritis (SpA) According to ASAS-criteria Unknown status NCT01426815 Phase 3 Placebo;Golimumab
37 The Effect of Certolizumab Pegol on MRI Synovitis and Bone Edema in Rheumatoid Arthritis Patients Completed NCT01213017 Phase 3 certolizumab pegol
38 Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee Completed NCT00604539 Phase 3 Chondroitin sulphate (Condrosan);Placebo
39 A Study of Tocilizumab in Combination With Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Moderate to Severe Active Rheumatoid Arthritis With an Inadequate Response to DMARDs Completed NCT00996606 Phase 3 DMARDs;Tocilizumab
40 A Phase IIIb Study of BMS-188667 in Subjects With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00420199 Phase 3 Abatacept;Placebo
41 Intra-Articular Injection of Etanercept in Patient Suffering From Rheumatoid Arthritis : a Double-Blind Randomized Study Completed NCT00522184 Phase 3
42 A Rheumatoid Arthritis Study to Assess Early Response to Abatacept+MTX as Defined by Improvement of Synovitis Measures by Power Doppler Ultrasonography Completed NCT00767325 Phase 3 Abatacept;Methotrexate
43 Magnetic Resonance Image Verified Early Response to Certolizumab Pegol in Subjects With Active Rheumatoid Arthritis (RA) Completed NCT01235598 Phase 3
44 Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever Completed NCT01705756 Phase 3 Kineret
45 Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)? Completed NCT02164214 Phase 3 etanercept Treatment
46 TORPEDO Study: A Study on Rapid Effect of Tocilizumab in Patients With Rheumatoid Arthritis With an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) or Anti-TNF Completed NCT00977106 Phase 3 tocilizumab [RoActemra/Actemra];placebo;tocilizumab [RoActemra/Actemra]
47 A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00578305 Phase 3 Placebo;Methylprednisolone;Methotrexate;Folic acid or folate
48 A Study of Tocilizumab (RoActemra) in Tocilizumab-Naive Participants With Rheumatoid Arthritis and Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) and/or Biologic Therapy Completed NCT02001987 Phase 3 Tocilizumab;Methotrexate;csDMARDs
49 An Open-Label Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid Arthritis Completed NCT01951170 Phase 3 Tocilizumab
50 Addition of Rituximab to Leflunomide in Patients With Active Rheumatoid Arthritis Completed NCT01244958 Phase 3 Placebo

Search NIH Clinical Center for Synovitis

Cochrane evidence based reviews: synovitis

Genetic Tests for Synovitis

Genetic tests related to Synovitis:

# Genetic test Affiliating Genes
1 Synovitis 30

Anatomical Context for Synovitis

MalaCards organs/tissues related to Synovitis:

42
Bone, T Cells, B Cells, Bone Marrow, Endothelial, Neutrophil, Monocytes

The Foundational Model of Anatomy Ontology organs/tissues related to Synovitis:

20
Synovial Membrane

Publications for Synovitis

Articles related to Synovitis:

(show top 50) (show all 2874)
# Title Authors Year
1
Can ultrasound-detected subclinical synovitis be an indicator of flare recurrence in juvenile idiopathic arthritis remission patients on tapered TNFi? ( 30873946 )
2019
2
Combination of ultrasound power Doppler-verified synovitis and seropositivity accurately identifies patients with early-stage rheumatoid arthritis. ( 30883001 )
2019
3
Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis. ( 30824919 )
2019
4
Subclinical synovitis and enthesitis in psoriasis patients and controls by ultrasonography in Saudi Arabia; incidence of psoriatic arthritis during two years. ( 30756253 )
2019
5
Hautentzündungen mit Arthritis, Synovitis und Enthesitis. Teil 2: Rheumatoide Arthritis, reaktive Arthritis, Morbus Reiter, Lyme-Borreliose, Dermatomyositis und Lupus erythematodes. ( 30762961 )
2019
6
Skin inflammation associated with arthritis, synovitis and enthesitis. Part 2: rheumatoid arthritis, reactive arthritis, Reiter's syndrome, Lyme borreliosis, dermatomyositis and lupus erythematosus. ( 30762968 )
2019
7
Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia. ( 30764862 )
2019
8
Skin inflammation associated with arthritis, synovitis and enthesitis. Part 1: psoriatic arthritis, SAPHO syndrome, Still's disease, Behçet's disease. ( 30615277 )
2019
9
Hautentzündungen mit Arthritis, Synovitis und Enthesitis. Teil 1: Psoriasisarthritis, SAPHO-Syndrom, Morbus Still, Morbus Behçet. ( 30615292 )
2019
10
Impact of subclinical synovitis in ankles and feet detected by ultrasonography in patients with rheumatoid arthritis. ( 30338640 )
2019
11
Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study. ( 30767869 )
2019
12
Monoclonal Gammopathy of Undetermined Significance in a Patient With Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis (SAPHO) Syndrome: Coincidence or Association? ( 30870251 )
2019
13
Can optical spectral transmission assess ultrasound-detected synovitis in hand osteoarthritis? ( 30794572 )
2019
14
A Phase 2 Trial of Lutikizumab, an Anti-Interleukin 1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis. ( 30653843 )
2019
15
Volume of hip synovitis detected on contrast-enhanced magnetic resonance imaging is associated with disease severity after collapse in osteonecrosis of the femoral head. ( 30697641 )
2019
16
Pigmented Villonodular Synovitis: Novel Role of Dual-Energy CT. ( 30614893 )
2019
17
Atypical Presentation of Pigmented Villonodular Synovitis: A Case Report. ( 30787857 )
2019
18
Osteochondral Lesion in Diffuse Pigmented Villonodular Synovitis of the Knee. ( 30871295 )
2019
19
Contrast-enhanced MRI compared to direct joint visualization at arthroscopy in pediatric patients with suspected temporomandibular joint synovitis. ( 30382321 )
2019
20
MRI of synovitis and joint fluid. ( 30618151 )
2019
21
Histologic assessment of ligament vascularity and synovitis in dogs with cranial cruciate ligament disease. ( 30681360 )
2019
22
Radioisotope Synoviorthesis in the Control of Refractory Synovitis in Castilla-La Mancha. A 10-year Experience. ( 30691947 )
2019
23
Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis. ( 30728752 )
2019
24
Diagnostic value of diffusion-weighted MRI for imaging synovitis in pediatric patients with inflammatory conditions of the knee joint. ( 30729445 )
2019
25
What Role Does Synovitis Play in Craniomandibular Dysfunction (CMD)? A 3T-MRI Study. ( 30754055 )
2019
26
Psoriatic Synovitis: Singularity and Potential Clinical Implications. ( 30805340 )
2019
27
Synovitis as a concomitant disease in shoulder pathologies. ( 30820695 )
2019
28
Dosing of intra-articular triamcinolone hexacetonide for knee synovitis in chronic polyarthritis: a randomized controlled study. ( 30843453 )
2019
29
A Case of Anti-PD-L1-associated Remitting Seronegative Symmetric Synovitis With Pitting Edema. ( 30850338 )
2019
30
MRI inflammation of the hand interosseous tendons occurs in anti-CCP-positive at-risk individuals and may precede the development of clinical synovitis. ( 30904831 )
2019
31
Comparison of Ultrasound, Radiography, and Clinical Investigations in the Diagnosis of Early Rheumatoid Synovitis in Patients with Nonspecific Musculoskeletal Symptoms: A Multicenter Cross-Sectional Study. ( 29939979 )
2018
32
Recurrent pigmented villonodular synovitis of the temporomandibular joint. ( 29904498 )
2018
33
Clinical, Imaging, and Pathological Suppression of Synovitis in Rheumatoid Arthritis: Is the Disease Curable? ( 29868592 )
2018
34
11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis. ( 29891135 )
2018
35
What does power Doppler signal indicate in rheumatoid synovitis? A point of view from synovial histopathology. ( 29366644 )
2018
36
Can effusion-synovitis measured on ultrasound or MRI predict response to intra-articular steroid injection in hip osteoarthritis? ( 29980827 )
2018
37
Pigmented villonodular synovitis managed by total synovectomy and cementless total hip arthroplasty. ( 29700612 )
2018
38
Serum matrix metalloproteinase 3 in detecting remitting seronegative symmetrical synovitis with pitting edema syndrome: A case report. ( 29774220 )
2018
39
Diffuse Pigmented Villonodular Synovitis Around the Ankle. ( 29634303 )
2018
40
Arthroscopic Management of Pigmented Villonodular Synovitis of the Hip in Children and Adolescents. ( 29594178 )
2018
41
Pigmented Villonodular Synovitis: A Close Mimic of Metastasis on<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29430127 )
2018
42
Nilotinib in locally advanced pigmented villonodular synovitis: challenges of a new targeted therapy. ( 29571947 )
2018
43
Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. ( 29637236 )
2018
44
Identification of pathways and genes associated with synovitis in osteoarthritis using bioinformatics analyses. ( 29968759 )
2018
45
Adalimumab as a successful treatment for acne fulminans and bilateral acute sacroiliitis with hip synovitis complicating isotretinoin therapy. ( 29284764 )
2018
46
Pigmented Villonodular Synovitis of the Knee: An Underappreciated Source of Pain in Children and Adolescents. ( 29917011 )
2018
47
Sustained intra-articular release of celecoxib in an equine repeated LPS synovitis model. ( 29729412 )
2018
48
Clinical utility of eco-color-power Doppler ultrasonography and contrast enhanced magnetic resonance imaging for interpretation and quantification of joint synovitis: a review. ( 29350637 )
2018
49
Necessity of adjuvant postoperative radiotherapy for diffuse pigmented villonodular synovitis of the knee: A case report and literature review. ( 29504995 )
2018
50
Pigmented villonodular synovitis in pediatric population: review of literature and a case report. ( 29343257 )
2018

Variations for Synovitis

Expression for Synovitis

Search GEO for disease gene expression data for Synovitis.

Pathways for Synovitis

Pathways related to Synovitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CD68 CRP CXCL8 ICAM1 IL18 IL1B
2
Show member pathways
13.38 CXCL8 ICAM1 IL18 IL1B IL1RN IL6
3
Show member pathways
12.93 CXCL8 ICAM1 IL18 IL1B IL6 TNF
4
Show member pathways
12.82 COMP ICAM1 MMP1 MMP13 MMP3 PRSS2
5
Show member pathways
12.8 CXCL8 IL18 IL1B IL6 TNF
6
Show member pathways
12.66 CXCL8 ICAM1 IL18 IL1B IL6 PRSS2
7 12.62 IL1B IL1RN TNF TNFSF11 VCAM1
8
Show member pathways
12.44 ICAM1 TNFRSF11B TNFSF11 VCAM1
9
Show member pathways
12.4 CRP ICAM1 IL1B IL6 TNF
10
Show member pathways
12.4 CXCL8 IL1B IL6 MMP1 MMP13 MMP3
11 12.38 ICAM1 IL6 TNF VCAM1
12
Show member pathways
12.33 CXCL8 IL1B IL6 TNF
13
Show member pathways
12.32 CXCL8 IL18 IL1B IL6 TNF
14
Show member pathways
12.31 CXCL8 ICAM1 IL1B MMP1 MMP13 MMP3
15
Show member pathways
12.3 CXCL8 IL18 IL1B IL1RN IL6 TNF
16
Show member pathways
12.29 MMP1 MMP13 MMP3 TNFSF11
17 12.28 IL18 IL1B IL6 TNF
18 12.26 CXCL8 IL1B IL1RN IL6 TNF
19
Show member pathways
12.24 CXCL8 IL1B IL6 TNF
20 12.18 ICAM1 IL1B SELE TNF VCAM1
21
Show member pathways
12.13 CXCL8 ICAM1 IL18 IL1B IL6
22
Show member pathways
12.13 IL1B IL6 MMP3 PRSS2 TNF
23
Show member pathways
12.12 IL18 IL1B IL6 TNF
24 12.1 IL1B TNF TNFRSF11B TNFSF11
25 12.1 CXCL8 ICAM1 IL1B IL6 TNF
26 12.08 ICAM1 MMP13 MMP3 VCAM1
27 12.06 ICAM1 IL1B IL6 MMP3 SELE TNF
28 12.05 CD163 CD68 IL6 TNF
29
Show member pathways
12.01 MMP1 MMP13 MMP3 PRSS2 TNF
30 11.98 CXCL8 ICAM1 IL1B IL6 SELE TNF
31 11.97 CXCL8 ICAM1 IL1B TNF TNFSF11 VCAM1
32 11.97 CXCL8 ICAM1 IL18 IL1B IL6 MMP1
33 11.96 CXCL8 IL1B IL6 TNF
34 11.91 CXCL8 IL18 IL1B IL6
35 11.9 CXCL8 ICAM1 IL6 MMP1 SELE
36
Show member pathways
11.89 CXCL8 ICAM1 IL6
37 11.85 CXCL8 IL1B IL6 TNF
38 11.83 CD163 IL1B IL6 TNF
39 11.81 IL18 IL1B TNF
40 11.77 CD163 CD68 IL18 IL1B IL1RN IL6
41 11.76 CXCL8 IL1B IL6 TNF
42 11.74 CXCL8 MMP1 MMP13 MMP3
43 11.69 CXCL8 IL18 IL1B IL6 TNF
44 11.65 CXCL8 IL6 SELE
45 11.64 CXCL8 ICAM1 IL18 IL1B IL1RN IL6
46 11.61 CXCL8 IL6 MMP1
47 11.59 IL1B IL6 TNF TNFRSF11B TNFSF11
48 11.58 ICAM1 IL6 TNF
49 11.58 IL18 IL1B TNF
50 11.55 ICAM1 SELE VCAM1

GO Terms for Synovitis

Cellular components related to Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CD163 COMP CRP CXCL8 IL18 IL1B
2 extracellular matrix GO:0031012 9.63 COMP MMP1 MMP13 MMP3 PRSS2 TNFRSF11B
3 extracellular space GO:0005615 9.53 COMP CRP CXCL8 ICAM1 IL18 IL1B

Biological processes related to Synovitis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.98 IL1B IL1RN TNF TNFSF11
2 response to lipopolysaccharide GO:0032496 9.97 ICAM1 IL1B SELE VCAM1
3 extracellular matrix organization GO:0030198 9.97 COMP ICAM1 TNF TNFRSF11B VCAM1
4 immune response GO:0006955 9.97 CXCL8 IL18 IL1B IL1RN IL6 PRG4
5 leukocyte migration GO:0050900 9.95 ICAM1 IL1B MMP1 SELE TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 IL1B IL6 TNF TNFSF11
7 calcium-mediated signaling GO:0019722 9.89 CXCL8 SELE TNFSF11
8 neutrophil chemotaxis GO:0030593 9.89 CXCL8 IL1B IL1RN
9 cellular response to organic cyclic compound GO:0071407 9.88 IL18 IL1B TNF
10 positive regulation of JNK cascade GO:0046330 9.88 IL1B IL1RN TNF TNFSF11
11 cellular response to lipopolysaccharide GO:0071222 9.88 CXCL8 ICAM1 IL1B IL1RN IL6 TNF
12 tumor necrosis factor-mediated signaling pathway GO:0033209 9.87 TNF TNFRSF11B TNFSF11
13 positive regulation of T cell proliferation GO:0042102 9.87 IL1B IL6 VCAM1
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 IL18 IL6 TNF
15 regulation of signaling receptor activity GO:0010469 9.86 CXCL8 IL18 IL1B IL1RN IL6 TNF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 IL18 IL1B TNF
17 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.83 ICAM1 SELE VCAM1
18 positive regulation of interferon-gamma production GO:0032729 9.82 IL18 IL1B TNF
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 ICAM1 IL1B TNF
20 regulation of cell adhesion GO:0030155 9.81 CXCL8 ICAM1 IL18
21 extracellular matrix disassembly GO:0022617 9.81 MMP1 MMP13 MMP3 PRSS2
22 acute-phase response GO:0006953 9.8 CD163 CRP IL6
23 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL1RN IL6 TNF
24 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 ICAM1 IL18 IL1B IL6 TNF TNFSF11
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.79 IL18 IL1B TNF
26 leukocyte cell-cell adhesion GO:0007159 9.77 ICAM1 SELE VCAM1
27 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
28 collagen catabolic process GO:0030574 9.76 MMP1 MMP13 MMP3 PRSS2
29 leukocyte tethering or rolling GO:0050901 9.73 SELE TNF VCAM1
30 negative regulation of bone resorption GO:0045779 9.71 IL6 TNFRSF11B
31 growth plate cartilage development GO:0003417 9.71 COMP MMP13
32 neutrophil activation GO:0042119 9.71 CXCL8 IL18
33 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B IL6 TNF
34 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.7 IL18 IL1B
35 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
36 response to glucocorticoid GO:0051384 9.7 IL1RN IL6 TNF
37 interleukin-6 production GO:0032635 9.69 IL18 IL1B
38 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
39 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.68 ICAM1 TNF
40 response to hypoxia GO:0001666 9.67 ICAM1 VCAM1
41 membrane to membrane docking GO:0022614 9.67 ICAM1 VCAM1
42 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.66 IL1RN IL6
43 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
44 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.65 IL18 IL1B
45 negative regulation of lipid storage GO:0010888 9.65 CRP IL6 TNF
46 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF
48 inflammatory response GO:0006954 9.61 CD163 CRP CXCL8 IL18 IL1B IL1RN
49 positive regulation of neuroinflammatory response GO:0150078 9.46 IL18 IL1B IL6 TNF
50 cytokine-mediated signaling pathway GO:0019221 9.36 CXCL8 ICAM1 IL18 IL1B IL1RN IL6

Molecular functions related to Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.46 MMP1 MMP13 MMP3 PRSS2
2 cytokine activity GO:0005125 9.23 CXCL8 IL18 IL1B IL1RN IL6 TNF
3 metalloendopeptidase activity GO:0004222 9.13 MMP1 MMP13 MMP3

Sources for Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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