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MCID: SYN007
MIFTS: 61

Synovitis

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Synovitis

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MalaCards integrated aliases for Synovitis:

Name: Synovitis 12 76 53 29 55 44 15 73

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:2703
MeSH 44 D013585
NCIt 50 C50766
SNOMED-CT 68 14107000
ICD10 33 M65.9
UMLS 73 C0039103
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Summaries for Synovitis

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Disease Ontology : 12 A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards based summary : Synovitis is related to noonan syndrome 1 and arthritis, and has symptoms including arthralgia, myalgia and metatarsalgia. An important gene associated with Synovitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Bevacizumab and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testes, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints that... more...

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Related Diseases for Synovitis

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Diseases related to Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 447)
# Related Disease Score Top Affiliating Genes
1 noonan syndrome 1 33.0 CXCL8 IL1B IL6 TNF
2 arthritis 30.5 CXCL8 IL18 IL1B IL1RN IL6 MMP1
3 osteoarthritis 30.5 COMP IL1B IL6 MMP1 MMP13 MMP3
4 septic arthritis 30.4 CRP CXCL8 MMP1 MMP3
5 osteomyelitis 30.2 CXCL8 IL1B IL1RN IL6 TNF TNFSF11
6 palindromic rheumatism 30.2 CRP IL1B TNF
7 reactive arthritis 30.2 COMP CRP TNF
8 angioimmunoblastic lymphadenopathy with dysproteinemia 30.0 IL6 TNF
9 chikungunya 29.9 IL1B IL6 TNF
10 bronchiolitis obliterans 29.9 CXCL8 IL6 TNF
11 spondylitis 29.8 CRP IL1RN IL6 TNF
12 viral infectious disease 29.8 CXCL8 IL1B IL6 TNF
13 familial mediterranean fever 29.7 CRP IL1B IL1RN TNF
14 hydrarthrosis 29.7 IL1B IL1RN MMP13 MMP3
15 fasciitis 29.7 CXCL8 IL18 IL6 TNF
16 pneumonia 29.7 CRP CXCL8 IL1B IL6 TNF
17 psoriasis 29.6 CXCL8 ICAM1 IL18 IL1B IL6 SELE
18 spondyloarthropathy 1 29.6 CD163 CRP MMP3 TNF TNFRSF11B
19 juvenile rheumatoid arthritis 29.6 CRP IL18 IL1B IL1RN IL6 TNF
20 relapsing polychondritis 29.6 COMP CRP IL6
21 arthropathy 29.6 COMP CRP PRG4 TNF TNFRSF11B TNFSF11
22 bronchiolitis 29.5 CRP CXCL8 IL6 TNF
23 pleurisy 29.5 CRP CXCL8 ICAM1 TNF
24 bone resorption disease 29.5 IL6 TNFRSF11B TNFSF11
25 hemophilic arthropathy 29.5 COMP TNFRSF11B TNFSF11
26 kawasaki disease 29.3 CRP IL6 MMP3 SELE TNF
27 diabetes mellitus, noninsulin-dependent 29.2 CRP IL18 IL6 SELE TNF VCAM1
28 psoriatic arthritis 29.2 COMP CRP IL1B IL6 MMP1 MMP3
29 systemic lupus erythematosus 29.0 CRP CXCL8 ICAM1 IL18 IL1B IL6
30 chronic kidney failure 29.0 CRP ICAM1 IL6 TNFRSF11B VCAM1
31 rheumatoid arthritis 28.9 COMP CRP CXCL8 ICAM1 IL18 IL1B
32 rheumatic disease 28.9 CD163 CRP IL18 IL1B TNF TNFRSF11B
33 bone inflammation disease 28.8 COMP CRP CXCL8 IL1B IL1RN IL6
34 inflammatory bowel disease 28.4 CRP CXCL8 ICAM1 IL18 IL1B IL1RN
35 pigmented villonodular synovitis 12.7
36 villonodular synovitis 12.5
37 remitting seronegative symmetrical synovitis with pitting edema 12.4
38 gonococcal synovitis 12.1
39 talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals 12.1
40 sapho syndrome 12.0
41 legg-calve-perthes disease 11.4
42 intermittent hydrarthrosis 11.4
43 eosinophilic fasciitis 11.3
44 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 11.3
45 blau syndrome 11.2
46 noonan syndrome 4 11.0
47 hyperostosis 10.6
48 giant cell tumor 10.4
49 spastic entropion 10.4 MMP1 MMP3
50 superior limbic keratoconjunctivitis 10.4 MMP1 MMP3

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to Synovitis
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Symptoms & Phenotypes for Synovitis

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UMLS symptoms related to Synovitis:


arthralgia, myalgia, metatarsalgia

MGI Mouse Phenotypes related to Synovitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 CD163 COMP CRP ICAM1 IL18 IL1B
2 growth/size/body region MP:0005378 10.15 COMP ICAM1 IL18 IL1B IL1RN IL6
3 cellular MP:0005384 10.14 CD163 COMP ICAM1 IL18 IL1RN IL6
4 hematopoietic system MP:0005397 10.13 CD163 CD68 ICAM1 IL18 IL1B IL1RN
5 homeostasis/metabolism MP:0005376 10.13 CD163 COMP CRP ICAM1 IL18 IL1B
6 immune system MP:0005387 10.06 CD163 CD68 COMP CRP ICAM1 IL18
7 integument MP:0010771 9.61 ICAM1 IL18 IL1B IL1RN IL6 MMP13
8 skeleton MP:0005390 9.32 CD68 COMP IL1B IL1RN IL6 MMP13
Sources

Drugs & Therapeutics for Synovitis

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Drugs for Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 199)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
3
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 59-05-2, 1959-05-2 126941
4
leucovorin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 6006 143
5
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 302-25-0
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 83-43-2 6741
7
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Early Phase 1 2921-57-5
8
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 50-24-8 5755
9
Infliximab Approved Phase 4,Phase 2,Not Applicable 170277-31-3
10
Sulfasalazine Approved Phase 4,Not Applicable 599-79-1 5353980 5359476
11
Hydroxychloroquine Approved Phase 4,Phase 2,Not Applicable 118-42-3 3652
12
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
13
Abatacept Approved Phase 4,Phase 3,Phase 1,Phase 2 332348-12-6 10237
14
rituximab Approved Phase 4,Phase 3,Phase 2 174722-31-7 10201696
15
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
16
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
17 Ixekizumab Approved, Investigational Phase 4,Phase 3,Phase 2 1143503-69-8
18
Leflunomide Approved, Investigational Phase 4,Phase 3 75706-12-6 3899
19
Apremilast Approved, Investigational Phase 4,Phase 2 608141-41-9 11561674
20
Liraglutide Approved Phase 4 204656-20-2 44147092
21
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 59-30-3 6037
23
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Early Phase 1 2920-86-7
24 Angiogenesis Modulating Agents Phase 4,Phase 2
25 Angiogenesis Inhibitors Phase 4,Phase 2
26 Folate Phase 4,Phase 3,Phase 2,Not Applicable
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
28 Rheumatoid Factor Phase 4
29 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
30 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
31 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
32 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
33 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
34 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
35 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
36 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
37 Vitamin B Complex Phase 4,Phase 3,Phase 2,Not Applicable
38 Analgesics Phase 4,Phase 3,Phase 2
39 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
40 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
41 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Early Phase 1
42 Prednisolone acetate Phase 4,Phase 3,Phase 2,Early Phase 1
43 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
44 Antiemetics Phase 4,Phase 3,Phase 2,Early Phase 1
45 Autonomic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
46 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
47 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
48 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
49 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
50 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 212)
# Name Status NCT ID Phase Drugs
1 Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis Unknown status NCT02060305 Phase 4 Bevacizumab intra-articular injection
2 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
3 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4 Etanercept, methotrexate and depomedrone;depemedrone
4 Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis Unknown status NCT01282528 Phase 4
5 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
6 A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs Completed NCT01034397 Phase 4 tocilizumab [RoActemra/Actemra];placebo;non-biological DMARDs
7 A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. Completed NCT00502853 Phase 4 rituximab [MabThera/Rituxan];Methotrexate
8 A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study Completed NCT00396747 Phase 4 Infliximab, methylprednisolone, methotrexate;Methotrexate;Methotrexate + Methylprednisolone;Methotrexate + Infliximab
9 The Effect of Corticotrophin (ACTH) in Combination With Methotrexate in Newly Diagnosed Rheumatoid Arthritis Patients Completed NCT01948388 Phase 4 corticotrophin 80 units
10 Musculoskeletal Ultrasound in Predicting Early Dose Titration With Tocilizumab Completed NCT01717859 Phase 4 Tocilizumab
11 Aiming for Remission in Rheumatoid Arthritis (RA) - the ARCTIC Trial Completed NCT01205854 Phase 4
12 A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects Completed NCT02198651 Phase 4 Adalimumab
13 Bone Mineral Density Changes Under Two Tibial Components in Total Knee Arthroplasty Completed NCT01764984 Phase 4
14 Prednisolone for Pain Reduction in Knee OA Completed NCT01619163 Phase 4 Placebo;Prednisolone
15 Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis Completed NCT00420927 Phase 4 methotrexate
16 Zushima Plaster for Treating Knee Osteoarthritis Completed NCT02770950 Phase 4 Zushima plaster with high dose;Zushima plaster with low dose;Indometacin Cataplasms
17 Study Comparing The Effect On Disease Activity When Reducing Or Discontinuing Etanercept In Subjects With RA Completed NCT00858780 Phase 4 Etanercept;Etanercept;Placebo
18 A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA) Completed NCT01185288 Phase 4 Methotrexate
19 Clinical Impact of Acthar in the Psoriatic Arthritis Patient (CLIPS) Recruiting NCT03419650 Phase 4 ACTHar
20 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis Recruiting NCT02765074 Phase 4 subcutaneous tocilizumab
21 Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders Recruiting NCT03227419 Phase 4 Tocilizumab Prefilled Syringe;Abatacept Prefilled Syringe
22 Efficacy, Radiographic and Laboratory Changes in Refractory Rheumatoid Arthritis Patients Treated With H.P. Acthar Gel Recruiting NCT03082573 Phase 4 H.P. Acthar gel
23 Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis Active, not recruiting NCT02437461 Phase 4 Triamcinolone hexacetonide
24 Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance Active, not recruiting NCT02928679 Phase 4 Liraglutide 3 mg (Saxenda);Liraglutide 3 mg placebo
25 A Study of Ixekizumab (LY2439821) Versus Adalimumab in Participants With Psoriatic Arthritis Active, not recruiting NCT03151551 Phase 4 Ixekizumab;Adalimumab
26 A Study to Evaluate the Impact of Apremilast (CC-10004) on MRI Outcomes in Subjects With Psoriatic Arthritis Not yet recruiting NCT03783026 Phase 4 CC-10004
27 The Comparative Study of Intra-articular Injection of Tocilizumab and Compound Betamethasone Not yet recruiting NCT03215407 Phase 4 Intra-articular Tocilizumab;Intra-articular Compound Betamethasone
28 Psoriatic Oligoarthritis Intervention With Symptomatic thErapy Not yet recruiting NCT03797872 Phase 4 Methotrexate;Sulfasalazine;Leflunomide;Methylprednisolone;Triamcinolone
29 Targeted Treatment Early With Etanercept + Methotrexate vs.T2T Care for DMARD-naïve Early RA Patients Based on naïve T-cell Stratification Not yet recruiting NCT03813771 Phase 4 Benepali;Sulfasalazine;Methotrexate;Hydroxychloroquine
30 Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging Study Terminated NCT01659242 Phase 4 Methotrexate plus sulfasalazine;Leflunomide
31 A Study of Efficacy of Rituximab [Mabthera/Rituxan] in Patients With Rheumatoid Arthritis Using Magnetic Resonance Imaging of the Hand (RESONAR) Terminated NCT01117129 Phase 4 rituximab [MabThera/Rituxan];placebo;methotrexate;rituximab [Mabthera/Rituxan]
32 A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs Withdrawn NCT01878318 Phase 4 methotrexate;tocilizumab [RoActemra/Actemra]
33 Treatment With Apremilast in Patients With Psoriatic Arthritis Withdrawn NCT02558361 Phase 4 Treatment with Apremilast
34 Abatacept Reversing Subclinical Inflammation as Measured by MRI in ACPA Positive Arthralgia Unknown status NCT02778906 Phase 3 Abatacept;Placebo
35 An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective Unknown status NCT02566967 Phase 3 tofacitinib
36 Exploration of TNF-alpha Blockade With Golimumab in the Induction of Clinical Remission in Patients With Early Peripheral Spondyloarthritis (SpA) According to ASAS-criteria Unknown status NCT01426815 Phase 3 Placebo;Golimumab
37 The Effect of Certolizumab Pegol on MRI Synovitis and Bone Edema in Rheumatoid Arthritis Patients Completed NCT01213017 Phase 3 certolizumab pegol
38 Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee Completed NCT00604539 Phase 3 Chondroitin sulphate (Condrosan);Placebo
39 A Study of Tocilizumab in Combination With Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Moderate to Severe Active Rheumatoid Arthritis With an Inadequate Response to DMARDs Completed NCT00996606 Phase 3 DMARDs;Tocilizumab
40 A Phase IIIb Study of BMS-188667 in Subjects With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00420199 Phase 3 Abatacept;Placebo
41 Intra-Articular Injection of Etanercept in Patient Suffering From Rheumatoid Arthritis : a Double-Blind Randomized Study Completed NCT00522184 Phase 3
42 A Rheumatoid Arthritis Study to Assess Early Response to Abatacept+MTX as Defined by Improvement of Synovitis Measures by Power Doppler Ultrasonography Completed NCT00767325 Phase 3 Abatacept;Methotrexate
43 Magnetic Resonance Image Verified Early Response to Certolizumab Pegol in Subjects With Active Rheumatoid Arthritis (RA) Completed NCT01235598 Phase 3
44 Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever Completed NCT01705756 Phase 3 Kineret
45 Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)? Completed NCT02164214 Phase 3 etanercept Treatment
46 TORPEDO Study: A Study on Rapid Effect of Tocilizumab in Patients With Rheumatoid Arthritis With an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) or Anti-TNF Completed NCT00977106 Phase 3 tocilizumab [RoActemra/Actemra];placebo;tocilizumab [RoActemra/Actemra]
47 A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00578305 Phase 3 Placebo;Methylprednisolone;Methotrexate;Folic acid or folate
48 A Study of Tocilizumab (RoActemra) in Tocilizumab-Naive Participants With Rheumatoid Arthritis and Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) and/or Biologic Therapy Completed NCT02001987 Phase 3 Tocilizumab;Methotrexate;csDMARDs
49 An Open-Label Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid Arthritis Completed NCT01951170 Phase 3 Tocilizumab
50 Addition of Rituximab to Leflunomide in Patients With Active Rheumatoid Arthritis Completed NCT01244958 Phase 3 Placebo

Search NIH Clinical Center for Synovitis

Cochrane evidence based reviews: synovitis

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Genetic Tests for Synovitis

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Genetic tests related to Synovitis:

# Genetic test Affiliating Genes
1 Synovitis 29
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Anatomical Context for Synovitis

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MalaCards organs/tissues related to Synovitis:

41
Bone, Bone Marrow, Testes, T Cells, Lung, Endothelial, B Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Synovitis:

19
Synovial Membrane
Sources

Publications for Synovitis

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Articles related to Synovitis:

(show top 50) (show all 1783)
# Title Authors Year
1
Comparison of Ultrasound, Radiography, and Clinical Investigations in the Diagnosis of Early Rheumatoid Synovitis in Patients with Nonspecific Musculoskeletal Symptoms: A Multicenter Cross-Sectional Study. ( 29939979 )
2018
2
Recurrent pigmented villonodular synovitis of the temporomandibular joint. ( 29904498 )
2018
3
Clinical, Imaging, and Pathological Suppression of Synovitis in Rheumatoid Arthritis: Is the Disease Curable? ( 29868592 )
2018
4
11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis. ( 29891135 )
2018
5
What does power Doppler signal indicate in rheumatoid synovitis? A point of view from synovial histopathology. ( 29366644 )
2018
6
Can effusion-synovitis measured on ultrasound or MRI predict response to intra-articular steroid injection in hip osteoarthritis? ( 29980827 )
2018
7
Pigmented villonodular synovitis managed by total synovectomy and cementless total hip arthroplasty. ( 29700612 )
2018
8
Serum matrix metalloproteinase 3 in detecting remitting seronegative symmetrical synovitis with pitting edema syndrome: A case report. ( 29774220 )
2018
9
Diffuse Pigmented Villonodular Synovitis Around the Ankle. ( 29634303 )
2018
10
Arthroscopic Management of Pigmented Villonodular Synovitis of the Hip in Children and Adolescents. ( 29594178 )
2018
11
Pigmented Villonodular Synovitis: A Close Mimic of Metastasis on<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29430127 )
2018
12
Nilotinib in locally advanced pigmented villonodular synovitis: challenges of a new targeted therapy. ( 29571947 )
2018
13
Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. ( 29637236 )
2018
14
Identification of pathways and genes associated with synovitis in osteoarthritis using bioinformatics analyses. ( 29968759 )
2018
15
Adalimumab as a successful treatment for acne fulminans and bilateral acute sacroiliitis with hip synovitis complicating isotretinoin therapy. ( 29284764 )
2018
16
Pigmented Villonodular Synovitis of the Knee: An Underappreciated Source of Pain in Children and Adolescents. ( 29917011 )
2018
17
Sustained intra-articular release of celecoxib in an equine repeated LPS synovitis model. ( 29729412 )
2018
18
Clinical utility of eco-color-power Doppler ultrasonography and contrast enhanced magnetic resonance imaging for interpretation and quantification of joint synovitis: a review. ( 29350637 )
2018
19
Necessity of adjuvant postoperative radiotherapy for diffuse pigmented villonodular synovitis of the knee: A case report and literature review. ( 29504995 )
2018
20
Pigmented villonodular synovitis in pediatric population: review of literature and a case report. ( 29343257 )
2018
21
In thumb base osteoarthritis structural damage is more strongly associated with pain than synovitis. ( 29709499 )
2018
22
The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound: the STARTER study. ( 29886430 )
2018
23
Synovitis of the knee following a high-pressure injection injury with hydraulic oil. ( 29770851 )
2018
24
In Rheumatoid Arthritis, Synovitis at Different Inflammatory Sites Is Dominated by Shared but Patient-Specific T Cell Clones. ( 29891556 )
2018
25
Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee: Complete Synovectomy and Septum Removal-Midterm Results. ( 29727868 )
2018
26
The role of ultrasound-defined tenosynovitis and synovitis in the prediction of rheumatoid arthritis development. ( 29618136 )
2018
27
Resolution of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) during Nivolumab therapy for non-small cell lung cancer: a case report. ( 29402438 )
2018
28
Nilotinib in locally advanced pigmented villonodular synovitis: a multicentre, open-label, single-arm, phase 2 trial. ( 29571946 )
2018
29
Serum Levels of proinflammatory, antiinflammatory cytokines and RANKL/OPG in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) Syndrome. ( 29694253 )
2018
30
Relationship between patient-reported swelling and MRI-defined effusion-synovitis in patients with meniscus tears and knee osteoarthritis. ( 29726627 )
2018
31
Treadmill Running Ameliorates Destruction of Articular Cartilage and Subchondral Bone, Not Only Synovitis, in a Rheumatoid Arthritis Rat Model. ( 29865282 )
2018
32
Computed Tomography Findings of Pigmented Villonodular Synovitis in a Dog. ( 29864767 )
2018
33
What is the added value of ultrasound joint examination for monitoring synovitis in rheumatoid arthritis and can it be used to guide treatment decisions? A systematic review and cost-effectiveness analysis. ( 29712616 )
2018
34
IMSYC immunologic synovitis score: A new score for synovial membrane characterization in inflammatory and non-inflammatory arthritis. ( 29709696 )
2018
35
Ultrasound of Subtalar Joint Synovitis in Patients with Rheumatoid Arthritis: Results of an OMERACT Reliability Exercise Using Consensual Definitions. ( 30385707 )
2018
36
Dihydroartemisinin derivative DC32 attenuates collagen-induced arthritis in mice by restoring the Treg/Th17 balance and inhibiting synovitis through down-regulation of IL-6. ( 30336338 )
2018
37
Impact of subclinical synovitis in ankles and feet detected by ultrasonography in patients with rheumatoid arthritis. ( 30338640 )
2018
38
Serum calprotectin as a marker of clinical and ultrasound-detected synovitis in early psoriatic and rheumatoid arthritis: results from a cross-sectional retrospective study. ( 30299248 )
2018
39
Ultra-low-dose CT detects synovitis in patients with suspected rheumatoid arthritis. ( 30269048 )
2018
40
Development of clinically apparent synovitis: a longitudinal study at the joint level during progression to inflammatory arthritis. ( 30233813 )
2018
41
Ultrasound Is Reasonably Accurate in Detecting Synovitis in Patients with Rheumatoid Arthritis. ( 30215940 )
2018
42
Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome - Two Presentations of the Same Disease? ( 30390722 )
2018
43
Validation of Musculoskeletal Ultrasound in the Assessment of Experimental Gout Synovitis. ( 29703511 )
2018
44
Chest pain that does not make the cut: a case study of a surgical patient with Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis syndrome. ( 30239087 )
2018
45
Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report. ( 30313072 )
2018
46
Pulmonary high-resolution computed tomography findings in patients with synovitis, acne, pustulosis, hyperostosis and osteitis syndrome. ( 30517110 )
2018
47
Paradoxical arthritis occurring during anti-TNF in patients with inflammatory bowel disease: histological and immunological features of a complex synovitis. ( 29657833 )
2018
48
Epithelioid myxofibrosarcoma developing at the injection site of Adalimumab therapy for psoriatic synovitis. ( 30185362 )
2018
49
Magnetic Resonance Imaging of synovitis in knees of patients with osteoarthritis without injected contrast agents using T1 quantification. ( 30292495 )
2018
50
Effusion-synovitis and infrapatellar fat pad signal intensity alteration differentiate accelerated knee osteoarthritis. ( 30346594 )
2018
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Variations for Synovitis

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Expression for Synovitis

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Search GEO for disease gene expression data for Synovitis.
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Pathways for Synovitis

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Pathways related to Synovitis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.05 CD68 CRP CXCL8 ICAM1 IL18 IL1B
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.38 CXCL8 ICAM1 IL18 IL1B IL1RN IL6
3
Allograft rejection 1 37
Show member pathways
 12.93 CXCL8 ICAM1 IL18 IL1B IL6 TNF
4
Influenza A 37
Show member pathways
 12.87 CXCL8 ICAM1 IL18 IL1B IL6 PRSS2
5
Degradation of the extracellular matrix 66
Show member pathways
 12.82 COMP ICAM1 MMP1 MMP13 MMP3 PRSS2
6
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.8 CXCL8 IL18 IL1B IL6 TNF
7
NF-kappaB Signaling 4
12.62 IL1B IL1RN TNF TNFSF11 VCAM1
8
Human T-cell leukemia virus 1 infection 37
12.45 ICAM1 IL6 TNF VCAM1
9
RANK Signaling in Osteoclasts 64
Show member pathways
 12.44 ICAM1 TNFRSF11B TNFSF11 VCAM1
10
Selenium Micronutrient Network 1
Show member pathways
 12.4 CRP ICAM1 IL1B IL6 TNF
11
IL-17 Family Signaling Pathways 65
Show member pathways
 12.4 CXCL8 IL1B IL6 MMP1 MMP13 MMP3
12
Toll Comparative Pathway 64
Show member pathways
 12.33 CXCL8 IL1B IL6 TNF
13
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.32 CXCL8 IL18 IL1B IL6 TNF
14
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.31 CXCL8 ICAM1 IL1B MMP1 MMP13 MMP3
15
IL-1 Family Signaling Pathways 65
Show member pathways
 12.3 CXCL8 IL18 IL1B IL1RN IL6 TNF
16
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 12.29 MMP1 MMP13 MMP3 TNFSF11
17
Tuberculosis 37
12.28 IL18 IL1B IL6 TNF
18
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.26 CXCL8 IL1B IL1RN IL6 TNF
19
Bacterial infections in CF airways 22
Show member pathways
 12.24 CXCL8 IL1B IL6 TNF
20
Fluid shear stress and atherosclerosis 37
12.18 ICAM1 IL1B SELE TNF VCAM1
21
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.13 CXCL8 ICAM1 IL18 IL1B IL6
22
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.13 IL1B IL6 MMP3 PRSS2 TNF
23
Th1 Differentiation Pathway 65
Show member pathways
 12.12 IL18 IL1B IL6 TNF
24
Osteoclast differentiation 37
12.1 IL1B TNF TNFRSF11B TNFSF11
25
Spinal Cord Injury 1
12.1 CXCL8 ICAM1 IL1B IL6 TNF
26
Adhesion 4
12.08 ICAM1 MMP13 MMP3 VCAM1
27
TNF signaling pathway 37
12.06 ICAM1 IL1B IL6 MMP3 SELE TNF
28
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.05 CD163 CD68 IL6 TNF
29
Matrix Metalloproteinases 1
Show member pathways
 12.01 MMP1 MMP13 MMP3 PRSS2 TNF
30
NF-kappa B signaling pathway 37
11.97 CXCL8 ICAM1 IL1B TNF TNFSF11 VCAM1
31
AGE-RAGE signaling pathway in diabetic complications 37
11.97 CXCL8 ICAM1 IL1B IL6 SELE TNF
32
Interleukin-4 and 13 signaling 66
11.97 CXCL8 ICAM1 IL18 IL1B IL6 MMP1
33
Amoebiasis 37
11.96 CXCL8 IL1B IL6 TNF
34
Salmonella infection (KEGG) 37
11.91 CXCL8 IL18 IL1B IL6
35
Glucocorticoid receptor regulatory network 1
11.9 CXCL8 ICAM1 IL6 MMP1 SELE
36
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.89 CXCL8 ICAM1 IL6
37
IL6-mediated signaling events 1
Show member pathways
 11.85 CRP IL6 TNFSF11
38
Pertussis 37
11.85 CXCL8 IL1B IL6 TNF
39
Dendritic Cells Developmental Lineage Pathway 65
11.83 CD163 IL1B IL6 TNF
40
Innate Lymphoid Cell Differentiation Pathways 65
11.81 IL18 IL1B TNF
41
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.77 CD163 CD68 IL18 IL1B IL1RN IL6
42
Lung fibrosis 1
11.76 CXCL8 IL1B IL6 TNF
43
Cell adhesion_ECM remodeling 22
11.74 CXCL8 MMP1 MMP13 MMP3
44
Legionellosis 37
11.69 CXCL8 IL18 IL1B IL6 TNF
45
ATF-2 transcription factor network 1
11.65 CXCL8 IL6 SELE
46
Interleukin-10 signaling 66
11.64 CXCL8 ICAM1 IL18 IL1B IL1RN IL6
47
Hepatitis C and Hepatocellular Carcinoma 1
11.61 CXCL8 IL6 MMP1
48
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.59 IL1B IL6 TNF TNFRSF11B TNFSF11
49
amb2 Integrin signaling 1
11.58 ICAM1 IL6 TNF
50
MSP-RON Signaling 64
11.58 IL18 IL1B TNF
Sources

GO Terms for Synovitis

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Cellular components related to Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CD163 COMP CRP CXCL8 IL18 IL1B
2 extracellular matrix GO:0031012 9.63 COMP MMP1 MMP13 MMP3 PRSS2 TNFRSF11B
3 extracellular space GO:0005615 9.53 COMP CRP CXCL8 ICAM1 IL18 IL1B

Biological processes related to Synovitis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.98 IL1B IL1RN TNF TNFSF11
2 response to hypoxia GO:0001666 9.97 ICAM1 IL1B MMP3 VCAM1
3 response to lipopolysaccharide GO:0032496 9.97 ICAM1 IL1B SELE VCAM1
4 extracellular matrix organization GO:0030198 9.97 COMP ICAM1 TNF TNFRSF11B VCAM1
5 immune response GO:0006955 9.97 CXCL8 IL18 IL1B IL1RN IL6 PRG4
6 leukocyte migration GO:0050900 9.95 ICAM1 IL1B MMP1 SELE TNF
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 IL1B IL6 TNF TNFSF11
8 calcium-mediated signaling GO:0019722 9.89 CXCL8 SELE TNFSF11
9 neutrophil chemotaxis GO:0030593 9.89 CXCL8 IL1B IL1RN
10 cellular response to organic cyclic compound GO:0071407 9.88 IL18 IL1B TNF
11 tumor necrosis factor-mediated signaling pathway GO:0033209 9.88 TNF TNFRSF11B TNFSF11
12 positive regulation of JNK cascade GO:0046330 9.88 IL1B IL1RN TNF TNFSF11
13 cellular response to lipopolysaccharide GO:0071222 9.88 CXCL8 ICAM1 IL1B IL1RN IL6 TNF
14 positive regulation of T cell proliferation GO:0042102 9.87 IL1B IL6 VCAM1
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 IL18 IL6 TNF
16 regulation of signaling receptor activity GO:0010469 9.86 CXCL8 IL18 IL1B IL1RN IL6 TNF
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 IL18 IL1B TNF
18 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.83 ICAM1 SELE VCAM1
19 response to glucocorticoid GO:0051384 9.83 IL1B IL1RN IL6 TNF
20 positive regulation of interferon-gamma production GO:0032729 9.82 IL18 IL1B TNF
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 ICAM1 IL1B TNF
22 regulation of cell adhesion GO:0030155 9.81 CXCL8 ICAM1 IL18
23 extracellular matrix disassembly GO:0022617 9.81 MMP1 MMP13 MMP3 PRSS2
24 positive regulation of JUN kinase activity GO:0043507 9.8 IL1B IL1RN TNF
25 acute-phase response GO:0006953 9.8 CD163 CRP IL6
26 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL1RN IL6 TNF
27 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 ICAM1 IL18 IL1B IL6 TNF TNFSF11
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.79 IL18 IL1B TNF
29 leukocyte cell-cell adhesion GO:0007159 9.77 ICAM1 SELE VCAM1
30 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
31 collagen catabolic process GO:0030574 9.76 MMP1 MMP13 MMP3 PRSS2
32 leukocyte tethering or rolling GO:0050901 9.73 SELE TNF VCAM1
33 negative regulation of bone resorption GO:0045779 9.72 IL6 TNFRSF11B
34 growth plate cartilage development GO:0003417 9.71 COMP MMP13
35 neutrophil activation GO:0042119 9.71 CXCL8 IL18
36 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.71 IL18 IL1B
37 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B IL6 TNF
38 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
39 interleukin-6 production GO:0032635 9.69 IL18 IL1B
40 negative regulation of glutamate secretion GO:0014050 9.69 IL1B IL1RN
41 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
42 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.68 ICAM1 TNF
43 membrane to membrane docking GO:0022614 9.67 ICAM1 VCAM1
44 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.66 IL1RN IL6
45 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
46 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.65 IL18 IL1B
47 negative regulation of lipid storage GO:0010888 9.65 CRP IL6 TNF
48 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF
50 chronic inflammatory response to antigenic stimulus GO:0002439 9.61 IL1B IL1RN TNF

Molecular functions related to Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.46 MMP1 MMP13 MMP3 PRSS2
2 metalloendopeptidase activity GO:0004222 9.26 MMP1 MMP13 MMP3 PRSS2
3 cytokine activity GO:0005125 9.23 CXCL8 IL18 IL1B IL1RN IL6 TNF
Sources

Sources for Synovitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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