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MCID: SYN007
MIFTS: 60

Synovitis

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Synovitis

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MalaCards integrated aliases for Synovitis:

Name: Synovitis 12 76 53 29 55 44 15 73

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:2703
MeSH 44 D013585
NCIt 50 C50766
ICD10 33 M65.9
UMLS 73 C0039103
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Summaries for Synovitis

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Disease Ontology : 12 A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards based summary : Synovitis is related to septic arthritis and spondylarthropathy, and has symptoms including arthralgia, metatarsalgia and myalgia. An important gene associated with Synovitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Bevacizumab and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include synovial membrane, bone and t cells, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints that... more...

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Related Diseases for Synovitis

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Diseases related to Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 409)
# Related Disease Score Top Affiliating Genes
1 septic arthritis 30.7 CRP CXCL8 MMP3
2 spondylarthropathy 30.5 CD163 TNF
3 palindromic rheumatism 30.4 CRP IL1B TNF
4 angioimmunoblastic lymphadenopathy with dysproteinemia 30.4 IL6 TNF
5 prostatitis 30.2 CXCL8 IL1B IL6 TNF
6 temporal arteritis 30.1 CRP IL1RN IL6
7 bronchiolitis obliterans 30.1 CXCL8 IL6 TNF
8 bronchiolitis 30.1 CXCL8 IL6 TNF
9 gingivitis 30.0 CXCL8 IL1B IL6 TNF
10 osteoarthritis 29.9 COMP IL1B IL6 MMP1 MMP13 MMP3
11 relapsing polychondritis 29.9 COMP CRP IL6
12 fasciitis 29.9 CXCL8 IL18 IL6 TNF
13 spondyloarthropathy 29.9 IL6 MMP3 TNF TNFSF11
14 conjunctivitis 29.8 CXCL8 ICAM1 IL6
15 hydrarthrosis 29.8 IL1B IL1RN IL6 MMP3
16 reactive arthritis 29.8 COMP CRP IL6 TNF
17 crohn's disease 29.8 CRP IL1B IL6 TNF
18 kaposi sarcoma 29.7 CXCL8 ICAM1 IL6 TNF
19 familial mediterranean fever 29.6 CRP IL1B IL1RN TNF
20 pneumonia 29.5 CRP CXCL8 IL1B IL6 TNF
21 spondyloarthropathy 1 29.5 CRP MMP3 TNF TNFRSF11B
22 osteomyelitis 29.4 CXCL8 IL1B IL1RN IL6 TNF TNFSF11
23 pleurisy 29.4 CRP CXCL8 ICAM1 TNF
24 spondylitis 29.3 CRP IL1RN IL6 TNF
25 brucellosis 29.0 CRP CXCL8 IL1RN IL6 TNF
26 arthritis 28.4 CXCL8 IL18 IL1B IL1RN IL6 MMP1
27 juvenile rheumatoid arthritis 28.3 CRP IL18 IL1B IL1RN IL6 TNF
28 chronic kidney failure 28.2 CRP ICAM1 IL6 TNFRSF11B VCAM1
29 arthropathy 28.2 COMP CRP PRG4 TNF TNFRSF11B TNFSF11
30 rheumatic disease 28.2 CD163 CRP IL1B TNF TNFRSF11B VCAM1
31 psoriasis 27.8 CXCL8 ICAM1 IL18 IL1B IL6 SELE
32 systemic lupus erythematosus 27.0 CRP ICAM1 IL18 IL6 SELE TNF
33 psoriatic arthritis 26.3 COMP CRP IL1B IL6 MMP1 MMP3
34 inflammatory bowel disease 24.4 CRP CXCL8 ICAM1 IL18 IL1B IL1RN
35 rheumatoid arthritis 23.4 COMP CRP CXCL8 ICAM1 IL18 IL1B
36 pigmented villonodular synovitis 12.6
37 villonodular synovitis 12.3
38 gonococcal synovitis 12.0
39 talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals 11.9
40 sapho syndrome 11.9
41 noonan syndrome 1 11.7
42 intermittent hydrarthrosis 11.2
43 legg-calve-perthes disease 11.2
44 eosinophilic fasciitis 11.2
45 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 11.2
46 superior limbic keratoconjunctivitis 11.0 MMP1 MMP3
47 blau syndrome 11.0
48 noonan syndrome 4 10.9
49 scorpion envenomation 10.8 IL6 TNF
50 spastic entropion 10.8 MMP1 MMP3

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to Synovitis
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Symptoms & Phenotypes for Synovitis

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UMLS symptoms related to Synovitis:


arthralgia, metatarsalgia, myalgia

MGI Mouse Phenotypes related to Synovitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 CD163 COMP IL1RN CRP ICAM1 IL6
2 growth/size/body region MP:0005378 10.15 IL1B COMP IL1RN ICAM1 IL6 IL18
3 cellular MP:0005384 10.14 CD163 COMP IL1RN ICAM1 IL6 IL18
4 homeostasis/metabolism MP:0005376 10.13 IL1B CD163 COMP IL1RN CRP ICAM1
5 hematopoietic system MP:0005397 10.1 IL1B CD163 IL1RN ICAM1 IL6 IL18
6 immune system MP:0005387 10.03 COMP IL1RN CRP ICAM1 IL6 IL18
7 integument MP:0010771 9.61 IL1B IL1RN ICAM1 IL6 IL18 MMP13
8 skeleton MP:0005390 9.28 IL1B COMP IL1RN IL6 TNFSF11 MMP3
Sources

Drugs & Therapeutics for Synovitis

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Drugs for Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 190)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
3
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 50-24-8 5755
6
Infliximab Approved Phase 4,Phase 2,Not Applicable 170277-31-3
7
Hydroxychloroquine Approved Phase 4,Phase 2,Not Applicable 118-42-3 3652
8
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
9
Sulfasalazine Approved Phase 4,Not Applicable 599-79-1 5353980 5359476
10
Adalimumab Approved Phase 4,Phase 2 331731-18-1 16219006
11
rituximab Approved Phase 4,Phase 3,Phase 2 174722-31-7 10201696
12
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
13
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1 332348-12-6 10237
14
Leflunomide Approved, Investigational Phase 4,Phase 3 75706-12-6 3899
15
Apremilast Approved, Investigational Phase 4,Phase 2 608141-41-9 11561674
16
Liraglutide Approved Phase 4 204656-20-2 44147092
17
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
18
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 59-30-3 6037
20
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 143 6006
21 Angiogenesis Inhibitors Phase 4,Phase 2
22 Angiogenesis Modulating Agents Phase 4,Phase 2
23 Analgesics Phase 4,Phase 3,Phase 2
24 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
25 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
26 Antiemetics Phase 4,Phase 3,Phase 2,Early Phase 1
27 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Early Phase 1
28 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
29 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
30 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Not Applicable
31 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
32 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Autonomic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
34 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
35 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
36 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
37 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
38 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
39 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
41 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
42 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Early Phase 1
44 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2,Early Phase 1
45 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Early Phase 1
46 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
47 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
48 Prednisolone acetate Phase 4,Phase 3,Phase 2,Early Phase 1
49 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Early Phase 1
50 Prednisolone phosphate Phase 4,Phase 3,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 202)
# Name Status NCT ID Phase Drugs
1 Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis Unknown status NCT02060305 Phase 4 Bevacizumab intra-articular injection
2 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
3 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4 Etanercept, methotrexate and depomedrone;depemedrone
4 Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis Unknown status NCT01282528 Phase 4
5 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
6 A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs Completed NCT01034397 Phase 4 tocilizumab [RoActemra/Actemra];placebo;non-biological DMARDs
7 A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. Completed NCT00502853 Phase 4 rituximab [MabThera/Rituxan];Methotrexate
8 A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study Completed NCT00396747 Phase 4 Infliximab, methylprednisolone, methotrexate;Methotrexate;Methotrexate + Methylprednisolone;Methotrexate + Infliximab
9 The Effect of Corticotrophin (ACTH) in Combination With Methotrexate in Newly Diagnosed Rheumatoid Arthritis Patients Completed NCT01948388 Phase 4 corticotrophin 80 units
10 Musculoskeletal Ultrasound in Predicting Early Dose Titration With Tocilizumab Completed NCT01717859 Phase 4 Tocilizumab
11 Aiming for Remission in Rheumatoid Arthritis (RA) - the ARCTIC Trial Completed NCT01205854 Phase 4
12 Bone Mineral Density Changes Under Two Tibial Components in Total Knee Arthroplasty Completed NCT01764984 Phase 4
13 Prednisolone for Pain Reduction in Knee OA Completed NCT01619163 Phase 4 Placebo;Prednisolone
14 Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis Completed NCT00420927 Phase 4 methotrexate
15 Study Comparing The Effect On Disease Activity When Reducing Or Discontinuing Etanercept In Subjects With RA Completed NCT00858780 Phase 4 Etanercept;Etanercept;Placebo
16 A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA) Completed NCT01185288 Phase 4 Methotrexate
17 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis Recruiting NCT02765074 Phase 4 subcutaneous tocilizumab
18 Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance Recruiting NCT02928679 Phase 4 Liraglutide 3 mg (Saxenda);Liraglutide 3 mg placebo
19 Efficacy, Radiographic and Laboratory Changes in Refractory Rheumatoid Arthritis Patients Treated With H.P. Acthar Gel Recruiting NCT03082573 Phase 4 H.P. Acthar gel
20 A Study of Ixekizumab (LY2439821) Versus Adalimumab in Participants With Psoriatic Arthritis Recruiting NCT03151551 Phase 4 Ixekizumab;Adalimumab
21 Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis Active, not recruiting NCT02437461 Phase 4 Triamcinolone hexacetonide
22 A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects (PREDICTRA) Active, not recruiting NCT02198651 Phase 4 Adalimumab
23 Zushima Plaster for Treating Knee Osteoarthritis Active, not recruiting NCT02770950 Phase 4 Zushima plaster with high dose;Zushima plaster with low dose;Indometacin Cataplasms
24 The Comparative Study of Intra-articular Injection of Tocilizumab and Compound Betamethasone Not yet recruiting NCT03215407 Phase 4 Intra-articular Tocilizumab;Intra-articular Compound Betamethasone
25 Clinical Impact of Acthar in the Psoriatic Arthritis Patient (CLIPS) Not yet recruiting NCT03419650 Phase 4 ACTHar
26 Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders Not yet recruiting NCT03227419 Phase 4 Tocilizumab Prefilled Syringe;Abatacept Prefilled Syringe
27 Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging Study Terminated NCT01659242 Phase 4 Methotrexate plus sulfasalazine;Leflunomide
28 A Study of Efficacy of Rituximab [Mabthera/Rituxan] in Patients With Rheumatoid Arthritis Using Magnetic Resonance Imaging of the Hand (RESONAR) Terminated NCT01117129 Phase 4 rituximab [MabThera/Rituxan];placebo;methotrexate;rituximab [Mabthera/Rituxan]
29 A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs Withdrawn NCT01878318 Phase 4 methotrexate;tocilizumab [RoActemra/Actemra]
30 Treatment With Apremilast in Patients With Psoriatic Arthritis Withdrawn NCT02558361 Phase 4 Treatment with Apremilast
31 Exploration of TNF-alpha Blockade With Golimumab in the Induction of Clinical Remission in Patients With Early Peripheral Spondyloarthritis (SpA) According to ASAS-criteria Unknown status NCT01426815 Phase 3 Placebo;Golimumab
32 The Effect of Certolizumab Pegol on MRI Synovitis and Bone Edema in Rheumatoid Arthritis Patients Completed NCT01213017 Phase 3 certolizumab pegol
33 Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee Completed NCT00604539 Phase 3 Chondroitin sulphate (Condrosan);Placebo
34 A Study of Tocilizumab in Combination With Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Moderate to Severe Active Rheumatoid Arthritis With an Inadequate Response to DMARDs Completed NCT00996606 Phase 3 DMARDs;Tocilizumab
35 A Phase IIIb Study of BMS-188667 in Subjects With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00420199 Phase 3 Abatacept;Placebo
36 Intra-Articular Injection of Etanercept in Patient Suffering From Rheumatoid Arthritis : a Double-Blind Randomized Study Completed NCT00522184 Phase 3
37 A Rheumatoid Arthritis Study to Assess Early Response to Abatacept+MTX as Defined by Improvement of Synovitis Measures by Power Doppler Ultrasonography Completed NCT00767325 Phase 3 Abatacept;Methotrexate
38 Magnetic Resonance Image Verified Early Response to Certolizumab Pegol in Subjects With Active Rheumatoid Arthritis (RA) Completed NCT01235598 Phase 3
39 Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever Completed NCT01705756 Phase 3 Kineret
40 Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)? Completed NCT02164214 Phase 3 etanercept Treatment
41 TORPEDO Study: A Study on Rapid Effect of Tocilizumab in Patients With Rheumatoid Arthritis With an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) or Anti-TNF Completed NCT00977106 Phase 3 tocilizumab [RoActemra/Actemra];placebo;tocilizumab [RoActemra/Actemra]
42 A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00578305 Phase 3 Placebo;Methylprednisolone;Methotrexate;Folic acid or folate
43 An Open-Label Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid Arthritis Completed NCT01951170 Phase 3 Tocilizumab
44 Addition of Rituximab to Leflunomide in Patients With Active Rheumatoid Arthritis Completed NCT01244958 Phase 3 Placebo
45 A Phase 2/3 Open-label Extension Study to Evaluate Long-Term Safety and Efficacy With VX-509 in Subjects With Rheumatoid Arthritis Completed NCT01830985 Phase 2, Phase 3 VX-509
46 A Study Of RoActemra/Actemra (Tocilizumab) in Tocilizumab-Naive Patients With Rheumatoid Arthritis With Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) or Biologic Therapy Completed NCT02001987 Phase 3 tocilizumab [RoActemra/Actemra]
47 Colchicine for Symptom and Inflammation in Knee Osteoarthritis Completed NCT02176460 Phase 2, Phase 3 Colchicine;Placebo
48 Study of the Effect of Chondroitin Sulfate on Structural Changes in Knee Osteoarthritis Patients Assessed by MRI Completed NCT01354145 Phase 3 Chondroitin sulfate;Celecoxib
49 Efficacy and Safety Study of Abatacept Subcutaneous Plus Methotrexate in Inducing Remission in Adults With Very Early Rheumatoid Arthritis Completed NCT01142726 Phase 3 Abatacept;Methotrexate;Abatacept placebo;Methotrexate placebo
50 A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Juvenile Idiopathic Arthritis From France Who Completed WA19977 Core Study Completed NCT01673919 Phase 3 tocilizumab [RoActemra/Actemra]

Search NIH Clinical Center for Synovitis

Cochrane evidence based reviews: synovitis

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Genetic Tests for Synovitis

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Genetic tests related to Synovitis:

# Genetic test Affiliating Genes
1 Synovitis 29
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Anatomical Context for Synovitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Synovitis:

19
Synovial Membrane

MalaCards organs/tissues related to Synovitis:

41
Bone, T Cells, Bone Marrow, Monocytes, B Cells, Endothelial, Liver
Sources

Publications for Synovitis

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Articles related to Synovitis:

(show top 50) (show all 1345)
# Title Authors Year
1
Comparison of Ultrasound, Radiography, and Clinical Investigations in the Diagnosis of Early Rheumatoid Synovitis in Patients with Nonspecific Musculoskeletal Symptoms: A Multicenter Cross-Sectional Study. ( 29939979 )
2018
2
Recurrent pigmented villonodular synovitis of the temporomandibular joint. ( 29904498 )
2018
3
Clinical, Imaging, and Pathological Suppression of Synovitis in Rheumatoid Arthritis: Is the Disease Curable? ( 29868592 )
2018
4
11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis. ( 29891135 )
2018
5
What does power Doppler signal indicate in rheumatoid synovitis? A point of view from synovial histopathology. ( 29366644 )
2018
6
Can effusion-synovitis measured on ultrasound or MRI predict response to intra-articular steroid injection in hip osteoarthritis? ( 29980827 )
2018
7
Pigmented villonodular synovitis managed by total synovectomy and cementless total hip arthroplasty. ( 29700612 )
2018
8
Serum matrix metalloproteinase 3 in detecting remitting seronegative symmetrical synovitis with pitting edema syndrome: A case report. ( 29774220 )
2018
9
Diffuse Pigmented Villonodular Synovitis Around the Ankle. ( 29634303 )
2018
10
Arthroscopic Management of Pigmented Villonodular Synovitis of the Hip in Children and Adolescents. ( 29594178 )
2018
11
Pigmented Villonodular Synovitis: A Close Mimic of Metastasis on<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29430127 )
2018
12
Nilotinib in locally advanced pigmented villonodular synovitis: challenges of a new targeted therapy. ( 29571947 )
2018
13
Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. ( 29637236 )
2018
14
Identification of pathways and genes associated with synovitis in osteoarthritis using bioinformatics analyses. ( 29968759 )
2018
15
Adalimumab as a successful treatment for acne fulminans and bilateral acute sacroiliitis with hip synovitis complicating isotretinoin therapy. ( 29284764 )
2018
16
Pigmented Villonodular Synovitis of the Knee: An Underappreciated Source of Pain in Children and Adolescents. ( 29917011 )
2018
17
Sustained intra-articular release of celecoxib in an equine repeated LPS synovitis model. ( 29729412 )
2018
18
Clinical utility of eco-color-power Doppler ultrasonography and contrast enhanced magnetic resonance imaging for interpretation and quantification of joint synovitis: a review. ( 29350637 )
2018
19
Necessity of adjuvant postoperative radiotherapy for diffuse pigmented villonodular synovitis of the knee: A case report and literature review. ( 29504995 )
2018
20
Pigmented villonodular synovitis in pediatric population: review of literature and a case report. ( 29343257 )
2018
21
In thumb base osteoarthritis structural damage is more strongly associated with pain than synovitis. ( 29709499 )
2018
22
The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound: the STARTER study. ( 29886430 )
2018
23
Synovitis of the knee following a high-pressure injection injury with hydraulic oil. ( 29770851 )
2018
24
In Rheumatoid Arthritis, Synovitis at Different Inflammatory Sites Is Dominated by Shared but Patient-Specific T Cell Clones. ( 29891556 )
2018
25
Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee: Complete Synovectomy and Septum Removal-Midterm Results. ( 29727868 )
2018
26
The role of ultrasound-defined tenosynovitis and synovitis in the prediction of rheumatoid arthritis development. ( 29618136 )
2018
27
Resolution of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) during Nivolumab therapy for non-small cell lung cancer: a case report. ( 29402438 )
2018
28
Nilotinib in locally advanced pigmented villonodular synovitis: a multicentre, open-label, single-arm, phase 2 trial. ( 29571946 )
2018
29
Serum Levels of proinflammatory, antiinflammatory cytokines and RANKL/OPG in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) Syndrome. ( 29694253 )
2018
30
Relationship between patient-reported swelling and MRI-defined effusion-synovitis in patients with meniscus tears and knee osteoarthritis. ( 29726627 )
2018
31
Treadmill Running Ameliorates Destruction of Articular Cartilage and Subchondral Bone, Not Only Synovitis, in a Rheumatoid Arthritis Rat Model. ( 29865282 )
2018
32
Computed Tomography Findings of Pigmented Villonodular Synovitis in a Dog. ( 29864767 )
2018
33
What is the added value of ultrasound joint examination for monitoring synovitis in rheumatoid arthritis and can it be used to guide treatment decisions? A systematic review and cost-effectiveness analysis. ( 29712616 )
2018
34
IMSYC immunologic synovitis score: A new score for synovial membrane characterization in inflammatory and non-inflammatory arthritis. ( 29709696 )
2018
35
Lowering the recurrence rate in pigmented villonodular synovitis: A series of 120 resections. ( 29788491 )
2018
36
Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis. ( 29191221 )
2017
37
Para-articular extraskeletal chondroma mimicking first metatarsophalangeal synovitis. ( 28828128 )
2017
38
Level of agreement between three-dimensional volumetric ultrasound and real-time conventional ultrasound in the assessment of synovitis, tenosynovitis and erosions in rheumatoid arthritis patients. ( 27896420 )
2017
39
Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome with Significant Bilateral Pleural Effusions. ( 28924111 )
2017
40
Localized pigmented villonodular synovitis of the ankle: Expect the unexpected. ( 28159047 )
2017
41
SOCS3 participates in cholinergic pathway regulation of synovitis in rheumatoid arthritis. ( 28914550 )
2017
42
Open and Arthroscopic with Mini-Open Surgical Hip Approaches for Treatment of Pigmented Villonodular Synovitis and Concomitant Hip Pathology. ( 28326214 )
2017
43
Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis. ( 28081709 )
2017
44
Proliferative Synovitis of the Shoulder Bursae is a Key Feature for Discriminating Elderly Onset Rheumatoid Arthritis Mimicking Polymyalgia Rheumatica From Polymyalgia Rheumatica. ( 29242702 )
2017
45
Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-Part 2: reliability and application to multiple joints of a standardised consensus-based scoring system. ( 28948984 )
2017
46
Surgical treatment for diffused-type giant cell tumor (pigmented villonodular synovitis) about the ankle joint. ( 29137617 )
2017
47
Functional complement activity is decisive for the development of chronic synovitis, osteophyte formation and processes of cell senescence in zymosan-induced arthritis. ( 28860038 )
2017
48
Flexor Hallucis Longus Tenosynovitis and First Metatarsophalangeal Synovitis After Penetrating Nail Prick Injury: Treated by Zone 3 Flexor Hallucis Longus Tendoscopy and Metatarsosesamoid Arthroscopy. ( 28580263 )
2017
49
SAPHO Syndrome: Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis. ( 28250311 )
2017
50
Multifocal pigmented villonodular synovitis coexisting in both the knee joint and the patella: a case report and literature review. ( 28683727 )
2017
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Variations for Synovitis

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Expression for Synovitis

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Search GEO for disease gene expression data for Synovitis.
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Pathways for Synovitis

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Pathways related to Synovitis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.05 CRP CXCL8 ICAM1 IL18 IL1B IL1RN
2
Integrin Pathway 64
Show member pathways
 13.42 CXCL8 ICAM1 MMP1 MMP13 MMP3 PRG4
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.34 CXCL8 ICAM1 IL18 IL1B IL1RN IL6
4
Allograft rejection 1 37
Show member pathways
 12.92 CXCL8 ICAM1 IL18 IL1B IL6 TNF
5
Influenza A 37
Show member pathways
 12.85 CXCL8 ICAM1 IL18 IL1B IL6 PRSS2
6
Degradation of the extracellular matrix 66
Show member pathways
 12.8 COMP ICAM1 MMP1 MMP13 MMP3 PRSS2
7
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.79 CXCL8 IL18 IL1B IL6 TNF
8
Regulation of IFNA signaling 66
Show member pathways
 12.67 CXCL8 IL18 IL1B IL6 TNF
9
NF-kappaB Signaling 4
12.6 IL1B IL1RN TNF TNFSF11 VCAM1
10
Th17 cell differentiation 37
Show member pathways
 12.45 IL18 IL1B IL6 TNF
11
RANK Signaling in Osteoclasts 64
Show member pathways
 12.43 ICAM1 TNFRSF11B TNFSF11 VCAM1
12
HTLV-I infection 37
12.43 ICAM1 IL6 TNF VCAM1
13
Folate Metabolism 1
Show member pathways
 12.38 CRP ICAM1 IL1B IL6 TNF
14
IL-17 Family Signaling Pathways 65
Show member pathways
 12.37 CXCL8 IL1B IL6 MMP1 MMP13 MMP3
15
Toll Comparative Pathway 64
Show member pathways
 12.31 CXCL8 IL1B IL6 TNF
16
Th1 Differentiation Pathway 65
Show member pathways
 12.29 IL18 IL1B IL6 TNF
17
IL-1 Family Signaling Pathways 65
Show member pathways
 12.29 CXCL8 IL18 IL1B IL1RN IL6 TNF
18
Tuberculosis 37
12.27 IL18 IL1B IL6 TNF
19
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.24 CXCL8 IL1B IL1RN IL6 TNF
20
Bacterial infections in CF airways 22
Show member pathways
 12.23 CXCL8 IL1B IL6 TNF
21
Fluid shear stress and atherosclerosis 37
12.16 ICAM1 IL1B SELE TNF VCAM1
22
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.12 CXCL8 ICAM1 IL18 IL1B IL6
23
Osteoclast differentiation 37
12.09 IL1B TNF TNFRSF11B TNFSF11
24
Spinal Cord Injury 1
12.08 CXCL8 ICAM1 IL1B IL6 TNF
25
Adhesion 4
12.06 ICAM1 MMP13 MMP3 VCAM1
26
TNF signaling pathway 37
12.01 ICAM1 IL1B IL6 MMP3 SELE TNF
27
Matrix Metalloproteinases 1
Show member pathways
 11.98 MMP1 MMP13 MMP3 PRSS2 TNF
28
Interleukin-4 and 13 signaling 66
11.97 CXCL8 ICAM1 IL18 IL1B IL6 MMP1
29
Amoebiasis 37
11.94 CXCL8 IL1B IL6 TNF
30
AGE-RAGE signaling pathway in diabetic complications 37
11.94 CXCL8 ICAM1 IL1B IL6 SELE TNF
31
NF-kappa B signaling pathway 37
11.93 CXCL8 ICAM1 IL1B TNF TNFSF11 VCAM1
32
Hematopoietic cell lineage 37
11.9 IL1B IL6 TNF
33
Salmonella infection (KEGG) 37
11.89 CXCL8 IL18 IL1B IL6
34
Glucocorticoid receptor regulatory network 1
11.89 CXCL8 ICAM1 IL6 MMP1 SELE
35
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.88 CXCL8 ICAM1 IL6
36
IL6-mediated signaling events 1
Show member pathways
 11.84 CRP IL6 TNFSF11
37
Pertussis 37
11.83 CXCL8 IL1B IL6 TNF
38
Dendritic Cells Developmental Lineage Pathway 65
11.81 CD163 IL1B IL6 TNF
39
Innate Lymphoid Cell Differentiation Pathways 65
11.8 IL18 IL1B TNF
40
Lung fibrosis 1
11.74 CXCL8 IL1B IL6 TNF
41
Cell adhesion_ECM remodeling 22
11.72 CXCL8 MMP1 MMP13 MMP3
42
Legionellosis 37
11.66 CXCL8 IL18 IL1B IL6 TNF
43
ATF-2 transcription factor network 1
11.63 CXCL8 IL6 SELE
44
Hepatitis C and Hepatocellular Carcinoma 1
11.6 CXCL8 IL6 MMP1
45
Interleukin-10 signaling 66
11.6 CXCL8 ICAM1 IL18 IL1B IL1RN IL6
46
amb2 Integrin signaling 1
11.56 ICAM1 IL6 TNF
47
MSP-RON Signaling 64
11.56 IL18 IL1B TNF
48
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.56 IL1B IL6 TNF TNFRSF11B TNFSF11
49
Thromboxane A2 receptor signaling 1
11.53 ICAM1 SELE VCAM1
50
Immune response_Role of integrins in NK cells cytotoxicity 22
11.51 CXCL8 ICAM1 VCAM1
Sources

GO Terms for Synovitis

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Cellular components related to Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CD163 COMP CRP CXCL8 IL18 IL1B
2 extracellular matrix GO:0031012 9.7 COMP ICAM1 MMP1 MMP13 MMP3 PRG4
3 external side of plasma membrane GO:0009897 9.56 CD163 ICAM1 TNF VCAM1
4 extracellular space GO:0005615 9.53 COMP CRP CXCL8 ICAM1 IL18 IL1B

Biological processes related to Synovitis according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.91 ICAM1 IL1B MMP1 SELE TNF
2 cellular response to lipopolysaccharide GO:0071222 9.88 CXCL8 ICAM1 IL6 TNF
3 extracellular matrix organization GO:0030198 9.88 COMP ICAM1 TNF TNFRSF11B VCAM1
4 cellular response to organic cyclic compound GO:0071407 9.86 IL18 IL1B TNF
5 positive regulation of JNK cascade GO:0046330 9.86 IL1B TNF TNFSF11
6 regulation of signaling receptor activity GO:0010469 9.86 CXCL8 IL18 IL1B IL1RN IL6 TNF
7 response to glucocorticoid GO:0051384 9.85 IL1RN IL6 TNF
8 positive regulation of T cell proliferation GO:0042102 9.85 IL1B IL6 VCAM1
9 positive regulation of DNA binding transcription factor activity GO:0051091 9.84 IL1B IL6 TNF TNFSF11
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 IL18 IL6 TNF
11 calcium-mediated signaling GO:0019722 9.83 CXCL8 SELE TNFSF11
12 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.82 ICAM1 SELE VCAM1
13 positive regulation of interleukin-6 production GO:0032755 9.81 IL1B IL6 TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 IL18 IL1B TNF
15 immune response GO:0006955 9.81 CXCL8 IL18 IL1B IL1RN IL6 PRG4
16 extracellular matrix disassembly GO:0022617 9.8 MMP1 MMP13 MMP3 PRSS2
17 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 ICAM1 IL1B IL6 TNF TNFSF11
18 response to lipopolysaccharide GO:0032496 9.8 CXCL8 ICAM1 IL1B SELE TNFRSF11B VCAM1
19 regulation of cell adhesion GO:0030155 9.78 CXCL8 ICAM1 IL18
20 positive regulation of interferon-gamma production GO:0032729 9.77 IL18 IL1B TNF
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 ICAM1 IL1B TNF
22 acute-phase response GO:0006953 9.74 CD163 CRP IL6
23 collagen catabolic process GO:0030574 9.73 MMP1 MMP13 MMP3 PRSS2
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 IL18 IL1B TNF
25 negative regulation of bone resorption GO:0045779 9.7 IL6 TNFRSF11B
26 leukocyte cell-cell adhesion GO:0007159 9.7 ICAM1 SELE VCAM1
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL1B TNF
28 neutrophil activation GO:0042119 9.69 CXCL8 IL18
29 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.69 IL18 IL1B
30 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
31 growth plate cartilage development GO:0003417 9.67 COMP MMP13
32 interleukin-6 production GO:0032635 9.67 IL18 IL1B
33 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
34 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.65 ICAM1 TNF
35 inflammatory response GO:0006954 9.65 CD163 CRP CXCL8 IL18 IL1B IL1RN
36 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
37 leukocyte tethering or rolling GO:0050901 9.63 SELE TNF VCAM1
38 fever generation GO:0001660 9.62 IL1B IL1RN
39 membrane to membrane docking GO:0022614 9.62 ICAM1 VCAM1
40 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.61 IL1RN IL6
41 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 IL1B TNF
43 negative regulation of lipid storage GO:0010888 9.54 CRP IL6 TNF
44 cytokine-mediated signaling pathway GO:0019221 9.36 CXCL8 ICAM1 IL18 IL1B IL1RN IL6
45 positive regulation of gene expression GO:0010628 10.04 CRP IL18 IL1B IL6 TNF

Molecular functions related to Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.46 MMP1 MMP13 MMP3 PRSS2
2 metalloendopeptidase activity GO:0004222 9.26 MMP1 MMP13 MMP3 PRSS2
3 cytokine activity GO:0005125 9.23 CXCL8 IL18 IL1B IL1RN IL6 TNF
Sources

Sources for Synovitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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