Synovitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SYN007 MIFTS: 59	Synovitis Categories: Rare diseases
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Aliases & Classifications for Synovitis

MalaCards integrated aliases for Synovitis:

Name: Synovitis ¹² ⁷⁷ ⁵⁴ ⁵⁶ ⁴⁵ ¹⁵ ¹⁷ ⁷⁴

Classifications:

MalaCards categories:
Global: Rare diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the musculoskeletal system and connective tissue

Disorders of synovium and tendon

Synovitis and tenosynovitis

Synovitis and tenosynovitis, unspecified

External Ids:

Disease Ontology ¹² DOID:2703

MeSH ⁴⁵ D013585

NCIt ⁵¹ C50766

SNOMED-CT ⁶⁹ 14107000

ICD10 ³⁴ M65.9

EFO ¹⁷ EFO_0008997

UMLS ⁷⁴ C0039103

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Summaries for Synovitis

Disease Ontology : ¹² A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards based summary : Synovitis is related to noonan syndrome 1 and septic arthritis, and has symptoms including arthralgia, myalgia and metatarsalgia. An important gene associated with Synovitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Etanercept and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and skin, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : ⁷⁷ Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints that... more...

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Related Diseases for Synovitis

Diseases related to Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 480)

#	Related Disease	Score	Top Affiliating Genes
1	noonan syndrome 1	33.2	CXCL8 IL1B IL6 TNF
2	septic arthritis	31.0	CRP CXCL8 MMP3
3	temporal arteritis	30.4	CRP IL1RN IL6 TNF
4	reactive arthritis	30.4	COMP CRP TNF
5	palindromic rheumatism	30.3	CRP IL1B TNF
6	arthritis	30.3	CXCL8 IL18 IL1B IL1RN IL6 MMP1
7	angioimmunoblastic lymphadenopathy with dysproteinemia	30.3	IL6 TNF
8	osteoarthritis	30.3	COMP IL1B IL6 MMP1 MMP13 MMP3
9	osteomyelitis	30.2	CXCL8 IL1B IL1RN IL6 TNF TNFSF11
10	chikungunya	30.1	IL1B IL6 TNF
11	pertussis	30.1	IL1B IL6 TNF
12	spondylitis	30.1	CRP IL1RN IL6 TNF
13	bronchiolitis obliterans	30.1	CXCL8 IL6 TNF
14	familial mediterranean fever	30.0	CRP IL1B IL1RN TNF
15	joint disorders	30.0	IL1B IL1RN IL6 MMP3 TNF TNFSF11
16	spondyloarthropathy 1	30.0	CD163 CRP MMP3 TNF TNFRSF11B
17	juvenile rheumatoid arthritis	30.0	CRP IL18 IL1B IL1RN IL6 TNF
18	spondyloarthropathy	29.8	IL6 MMP3 TNF TNFSF11
19	fasciitis	29.8	CXCL8 IL18 IL6 TNF
20	hydrarthrosis	29.8	IL1B IL1RN MMP13 MMP3
21	bone resorption disease	29.8	IL6 TNFRSF11B TNFSF11
22	hemophilic arthropathy	29.7	COMP TNFRSF11B TNFSF11
23	pneumonia	29.7	CRP CXCL8 IL1B IL6 TNF
24	relapsing polychondritis	29.7	COMP CRP IL6
25	lyme disease	29.6	CRP IL1B IL6 TNF
26	bronchiolitis	29.6	CRP CXCL8 IL6 TNF
27	lymphadenitis	29.6	CXCL8 ICAM1 IL18 IL1B TNF
28	pleurisy	29.5	CRP CXCL8 ICAM1 TNF
29	arthropathy	29.5	COMP CRP PRG4 TNF TNFRSF11B TNFSF11
30	polyarteritis nodosa	29.4	CRP IL6 SELE
31	rheumatic disease	29.3	CD163 CRP IL18 IL1B TNF TNFRSF11B
32	inflammatory bowel disease	29.3	CRP CXCL8 IL18 IL1B IL6 TNF
33	vasculitis	29.1	CRP ICAM1 SELE TNF VCAM1
34	chronic kidney failure	29.0	CRP ICAM1 IL6 TNFRSF11B VCAM1
35	kawasaki disease	29.0	CRP IL6 MMP3 SELE TNF
36	bone inflammation disease	28.9	COMP CRP CXCL8 IL1B IL1RN IL6
37	pericarditis	28.7	CRP IL1B IL1RN IL6 PRG4 TNF
38	psoriatic arthritis	28.7	COMP CRP IL1B IL6 MMP1 MMP3
39	systemic lupus erythematosus	28.6	CRP ICAM1 IL18 IL1B IL6 SELE
40	rheumatoid arthritis	27.9	COMP CRP CXCL8 ICAM1 IL18 IL1B
41	pigmented villonodular synovitis	12.8
42	villonodular synovitis	12.5
43	remitting seronegative symmetrical synovitis with pitting edema	12.5
44	talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals	12.2
45	gonococcal synovitis	12.2
46	sapho syndrome	12.1
47	legg-calve-perthes disease	11.4
48	tenosynovial giant cell tumor	11.4
49	intermittent hydrarthrosis	11.4
50	noonan syndrome 4	11.4

Graphical network of the top 20 diseases related to Synovitis:

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Symptoms & Phenotypes for Synovitis

UMLS symptoms related to Synovitis:

arthralgia, myalgia, metatarsalgia

MGI Mouse Phenotypes related to Synovitis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.25	CD163 COMP CRP ICAM1 IL18 IL1B
2	growth/size/body region	MP:0005378	10.15	COMP ICAM1 IL18 IL1B IL1RN IL6
3	cellular	MP:0005384	10.14	CD163 COMP ICAM1 IL18 IL1RN IL6
4	hematopoietic system	MP:0005397	10.13	CD163 CD68 ICAM1 IL18 IL1B IL1RN
5	homeostasis/metabolism	MP:0005376	10.13	CD163 COMP CRP ICAM1 IL18 IL1B
6	immune system	MP:0005387	10.06	CD163 CD68 COMP CRP ICAM1 IL18
7	integument	MP:0010771	9.61	ICAM1 IL18 IL1B IL1RN IL6 MMP13
8	skeleton	MP:0005390	9.32	CD68 COMP IL1B IL1RN IL6 MMP13

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Drugs & Therapeutics for Synovitis

Drugs for Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 202)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Etanercept

Approved, Investigational

Phase 4,Phase 3,Phase 2

185243-69-0

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Early Phase 1

302-25-0

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Early Phase 1

83-43-2

6741

leucovorin

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

58-05-9

143 6006

Methotrexate

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

1959-05-2, 59-05-2

126941

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 2,Early Phase 1

2921-57-5

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Early Phase 1

50-24-8

5755

Infliximab

Approved

Phase 4,Phase 2,Not Applicable

170277-31-3

Sulfasalazine

Approved

Phase 4,Not Applicable

599-79-1

5359476 5353980

Hydroxychloroquine

Approved

Phase 4,Phase 2,Not Applicable

118-42-3

3652

Adalimumab

Approved

Phase 4,Phase 3,Phase 2

331731-18-1

16219006

Tofacitinib

Approved, Investigational

Phase 4,Phase 3,Phase 2

477600-75-2

Abatacept

Approved

Phase 4,Phase 3,Phase 2,Phase 1

332348-12-6

10237

rituximab

Approved

Phase 4,Phase 3,Phase 2

174722-31-7

10201696

Liraglutide

Approved

Phase 4

204656-20-2

44147092

Indomethacin

Approved, Investigational

Phase 4

53-86-1

3715

Apremilast

Approved, Investigational

Phase 4,Phase 2

608141-41-9

11561674

Triamcinolone

Approved, Vet_approved

Phase 4,Phase 2

124-94-7

31307

Ixekizumab

Approved, Investigational

Phase 4,Phase 3,Phase 2

1143503-69-8

Leflunomide

Approved, Investigational

Phase 4,Phase 3

75706-12-6

3899

Betamethasone

Approved, Vet_approved

Phase 4

378-44-9

9782

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

59-30-3

6037

Prednisolone hemisuccinate

Experimental

Phase 4,Phase 3,Phase 2,Early Phase 1

2920-86-7

Immunologic Factors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Protective Agents

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Autonomic Agents

Phase 4,Phase 3,Phase 2,Early Phase 1

glucocorticoids

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Antimetabolites, Antineoplastic

Phase 4,Phase 3,Phase 2,Not Applicable

Rheumatoid Factor

Phase 4

Neuroprotective Agents

Phase 4,Phase 3,Phase 2,Early Phase 1

Antineoplastic Agents, Hormonal

Phase 4,Phase 3,Phase 2,Early Phase 1

Folate

Phase 4,Phase 3,Phase 2,Not Applicable

Antirheumatic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Vitamin B Complex

Phase 4,Phase 3,Phase 2,Not Applicable

Folic Acid Antagonists

Phase 4,Phase 3,Phase 2,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Dermatologic Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Vitamin B9

Phase 4,Phase 3,Phase 2,Not Applicable

Immunosuppressive Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Early Phase 1

Analgesics

Phase 4,Phase 3,Phase 2

Analgesics, Non-Narcotic

Phase 4,Phase 3,Phase 2

Anti-Inflammatory Agents, Non-Steroidal

Phase 4,Phase 3,Phase 2

Antibodies

Phase 4,Phase 3,Phase 2,Phase 1

Antiemetics

Phase 4,Phase 3,Phase 2,Early Phase 1

Prednisolone acetate

Phase 4,Phase 3,Phase 2,Early Phase 1

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Methylprednisolone Acetate

Phase 4,Phase 3,Phase 2,Early Phase 1

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 220)

#	Name	Status	NCT ID	Phase	Drugs
1	Targeting Synovitis in Early Rheumatoid Arthritis	Unknown status	NCT00920478	Phase 4
2	Remission Induction in Very Early Rheumatoid Arthritis	Unknown status	NCT00523692	Phase 4	Etanercept, methotrexate and depomedrone;depemedrone
3	Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis	Unknown status	NCT01282528	Phase 4
4	Very Early Versus Delayed Etanercept in Patients With RA	Unknown status	NCT02433184	Phase 4	Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
5	Efficacy, Radiographic and Laboratory Changes in Refractory Rheumatoid Arthritis Patients Treated With H.P. Acthar Gel	Unknown status	NCT03082573	Phase 4	H.P. Acthar gel
6	A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs	Completed	NCT01034397	Phase 4	tocilizumab [RoActemra/Actemra];placebo;non-biological DMARDs
7	A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis.	Completed	NCT00502853	Phase 4	rituximab [MabThera/Rituxan];Methotrexate
8	A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study	Completed	NCT00396747	Phase 4	Infliximab, methylprednisolone, methotrexate;Methotrexate;Methotrexate + Methylprednisolone;Methotrexate + Infliximab
9	The Effect of Corticotrophin (ACTH) in Combination With Methotrexate in Newly Diagnosed Rheumatoid Arthritis Patients	Completed	NCT01948388	Phase 4	corticotrophin 80 units
10	Musculoskeletal Ultrasound in Predicting Early Dose Titration With Tocilizumab	Completed	NCT01717859	Phase 4	Tocilizumab
11	Aiming for Remission in Rheumatoid Arthritis (RA) - the ARCTIC Trial	Completed	NCT01205854	Phase 4
12	A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects	Completed	NCT02198651	Phase 4	Adalimumab
13	Bone Mineral Density Changes Under Two Tibial Components in Total Knee Arthroplasty	Completed	NCT01764984	Phase 4
14	Prednisolone for Pain Reduction in Knee OA	Completed	NCT01619163	Phase 4	Placebo;Prednisolone
15	Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis	Completed	NCT00420927	Phase 4	methotrexate
16	Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance	Completed	NCT02928679	Phase 4	Liraglutide 3 mg (Saxenda);Liraglutide 3 mg placebo
17	Zushima Plaster for Treating Knee Osteoarthritis	Completed	NCT02770950	Phase 4	Zushima plaster with high dose;Zushima plaster with low dose;Indometacin Cataplasms
18	Musculoskeletal Ultrasound Assessment of Therapeutic Response of Tofacitinib in Rheumatoid Arthritis Patients	Completed	NCT02321930	Phase 4	tofacitinib 5mg po bid
19	Study Comparing The Effect On Disease Activity When Reducing Or Discontinuing Etanercept In Subjects With RA	Completed	NCT00858780	Phase 4	Etanercept;Etanercept;Placebo
20	A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA)	Completed	NCT01185288	Phase 4	Methotrexate
21	A Study to Evaluate the Impact of Apremilast (CC-10004) on MRI Outcomes in Subjects With Psoriatic Arthritis	Recruiting	NCT03783026	Phase 4	CC-10004
22	Clinical Impact of Acthar in the Psoriatic Arthritis Patient (CLIPS)	Recruiting	NCT03419650	Phase 4	ACTHar
23	Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis	Recruiting	NCT02765074	Phase 4	subcutaneous tocilizumab
24	Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders	Recruiting	NCT03227419	Phase 4	Tocilizumab Prefilled Syringe;Abatacept Prefilled Syringe
25	Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis	Active, not recruiting	NCT02437461	Phase 4	Triamcinolone hexacetonide
26	A Study of Ixekizumab (LY2439821) Versus Adalimumab in Participants With Psoriatic Arthritis	Active, not recruiting	NCT03151551	Phase 4	Ixekizumab;Adalimumab
27	The Comparative Study of Intra-articular Injection of Tocilizumab and Compound Betamethasone	Not yet recruiting	NCT03215407	Phase 4	Intra-articular Tocilizumab;Intra-articular Compound Betamethasone
28	Lipogems Prospective Study	Not yet recruiting	NCT03922490	Phase 4
29	Psoriatic Oligoarthritis Intervention With Symptomatic thErapy	Not yet recruiting	NCT03797872	Phase 4	Methotrexate;Sulfasalazine;Leflunomide;Methylprednisolone;Triamcinolone
30	Targeted Treatment Early With Etanercept + Methotrexate vs.T2T Care for DMARD-naïve Early RA Patients Based on naïve T-cell Stratification	Not yet recruiting	NCT03813771	Phase 4	Benepali;Sulfasalazine;Methotrexate;Hydroxychloroquine
31	Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging Study	Terminated	NCT01659242	Phase 4	Methotrexate plus sulfasalazine;Leflunomide
32	A Study of Efficacy of Rituximab [Mabthera/Rituxan] in Patients With Rheumatoid Arthritis Using Magnetic Resonance Imaging of the Hand (RESONAR)	Terminated	NCT01117129	Phase 4	rituximab [MabThera/Rituxan];placebo;methotrexate;rituximab [Mabthera/Rituxan]
33	A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs	Withdrawn	NCT01878318	Phase 4	methotrexate;tocilizumab [RoActemra/Actemra]
34	Treatment With Apremilast in Patients With Psoriatic Arthritis	Withdrawn	NCT02558361	Phase 4	Treatment with Apremilast
35	Abatacept Reversing Subclinical Inflammation as Measured by MRI in ACPA Positive Arthralgia	Unknown status	NCT02778906	Phase 3	Abatacept;Placebo
36	An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective	Unknown status	NCT02566967	Phase 3	tofacitinib
37	Exploration of TNF-alpha Blockade With Golimumab in the Induction of Clinical Remission in Patients With Early Peripheral Spondyloarthritis (SpA) According to ASAS-criteria	Unknown status	NCT01426815	Phase 3	Placebo;Golimumab
38	The Effect of Certolizumab Pegol on MRI Synovitis and Bone Edema in Rheumatoid Arthritis Patients	Completed	NCT01213017	Phase 3	certolizumab pegol
39	Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee	Completed	NCT00604539	Phase 3	Chondroitin sulphate (Condrosan);Placebo
40	A Study of Tocilizumab in Combination With Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Moderate to Severe Active Rheumatoid Arthritis With an Inadequate Response to DMARDs	Completed	NCT00996606	Phase 3	DMARDs;Tocilizumab
41	A Phase IIIb Study of BMS-188667 in Subjects With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate	Completed	NCT00420199	Phase 3	Abatacept;Placebo
42	Intra-Articular Injection of Etanercept in Patient Suffering From Rheumatoid Arthritis : a Double-Blind Randomized Study	Completed	NCT00522184	Phase 3
43	A Rheumatoid Arthritis Study to Assess Early Response to Abatacept+MTX as Defined by Improvement of Synovitis Measures by Power Doppler Ultrasonography	Completed	NCT00767325	Phase 3	Abatacept;Methotrexate
44	Magnetic Resonance Image Verified Early Response to Certolizumab Pegol in Subjects With Active Rheumatoid Arthritis (RA)	Completed	NCT01235598	Phase 3
45	Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever	Completed	NCT01705756	Phase 3	Kineret
46	Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)?	Completed	NCT02164214	Phase 3	etanercept Treatment
47	TORPEDO Study: A Study on Rapid Effect of Tocilizumab in Patients With Rheumatoid Arthritis With an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) or Anti-TNF	Completed	NCT00977106	Phase 3	tocilizumab [RoActemra/Actemra];placebo;tocilizumab [RoActemra/Actemra]
48	A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate	Completed	NCT00578305	Phase 3	Placebo;Methylprednisolone;Methotrexate;Folic acid or folate
49	A Study of Tocilizumab (RoActemra) in Tocilizumab-Naive Participants With Rheumatoid Arthritis and Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) and/or Biologic Therapy	Completed	NCT02001987	Phase 3	Tocilizumab;Methotrexate;csDMARDs
50	An Open-Label Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid Arthritis	Completed	NCT01951170	Phase 3	Tocilizumab

Search NIH Clinical Center for Synovitis

Cochrane evidence based reviews: synovitis

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Genetic Tests for Synovitis

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Anatomical Context for Synovitis

MalaCards organs/tissues related to Synovitis:

⁴²

Bone, T Cells, Skin, Bone Marrow, B Cells, Monocytes, Heart

The Foundational Model of Anatomy Ontology organs/tissues related to Synovitis:

²⁰

Synovial Membrane

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Publications for Synovitis

Articles related to Synovitis:

(show top 50) (show all 2881)

#	Title	Authors	Year
1	Correlation of anxiety and chronic pain to grade of synovitis in patients with knee osteoarthritis. ( 30946731 )	Ostojic M...Soljic V	2019
2	The Bone Marrow Edema Links to an Osteoclastic Environment and Precedes Synovitis During the Development of Collagen Induced Arthritis. ( 31068949 )	Wang F...Tan W	2019
3	Real benefits of ultrasound evaluation of hand and foot synovitis for better characterisation of the disease activity in rheumatoid arthritis. ( 31028442 )	Ciurtin C...Giles I	2019
4	The superb microvascular imaging is more sensitive than conventional power Doppler imaging in detection of active synovitis in patients with rheumatoid arthritis. ( 31030360 )	Lee GY...Song JS	2019
5	Rheumatoid arthritis-like active synovitis with T-cell activation in a case of idiopathic multicentric Castleman disease: A case report. ( 31045763 )	Otsuka M...Kawakami A	2019
6	Skin inflammation associated with arthritis, synovitis and enthesitis. Part 1: psoriatic arthritis, SAPHO syndrome, Still's disease, Behçet's disease. ( 30958944 )		2019
7	Intra-articular leflunomide-loaded poly(ε-caprolactone) implants to treat synovitis in rheumatoid arthritis. ( 30940304 )	Gomes TF...Da Silva GR	2019
8	Can ultrasound-detected subclinical synovitis be an indicator of flare recurrence in juvenile idiopathic arthritis remission patients on tapered TNFi? ( 30873946 )	Nieto-Gonz?lez JC...Naredo E	2019
9	Combination of ultrasound power Doppler-verified synovitis and seropositivity accurately identifies patients with early-stage rheumatoid arthritis. ( 30883001 )	Kawashiri SY...Kawakami A	2019
10	Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis. ( 30824919 )	Hensor EMA...Morgan AW	2019
11	Skin inflammation associated with arthritis, synovitis and enthesitis. Part 2: rheumatoid arthritis, reactive arthritis, Reiter's syndrome, Lyme borreliosis, dermatomyositis and lupus erythematosus. ( 30762968 )	Schempp CM...Finzel S	2019
12	Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia. ( 30764862 )	Ohrndorf S...van der Helm-van Mil AHM	2019
13	Subclinical synovitis and enthesitis in psoriasis patients and controls by ultrasonography in Saudi Arabia; incidence of psoriatic arthritis during two years. ( 30756253 )	Elnady B...Rasker JJ	2019
14	Hautentzündungen mit Arthritis, Synovitis und Enthesitis. Teil 2: Rheumatoide Arthritis, reaktive Arthritis, Morbus Reiter, Lyme-Borreliose, Dermatomyositis und Lupus erythematodes. ( 30762961 )	Schempp CM...Finzel S	2019
15	Skin inflammation associated with arthritis, synovitis and enthesitis. Part 1: psoriatic arthritis, SAPHO syndrome, Still's disease, Behçet's disease. ( 30615277 )	Huhn CK...Finzel S	2019
16	Hautentzündungen mit Arthritis, Synovitis und Enthesitis. Teil 1: Psoriasisarthritis, SAPHO-Syndrom, Morbus Still, Morbus Behçet. ( 30615292 )	Huhn CK...Finzel S	2019
17	Impact of subclinical synovitis in ankles and feet detected by ultrasonography in patients with rheumatoid arthritis. ( 30338640 )	Inamo J...Takeuchi T	2019
18	Serum calprotectin as a marker of ultrasound-detected synovitis in early psoriatic and rheumatoid arthritis: results from a cross-sectional retrospective study. ( 30299248 )	Sakellariou G...Montecucco C	2019
19	Ultra-low-dose CT detects synovitis in patients with suspected rheumatoid arthritis. ( 30269048 )	Diekhoff T...Hermann KG	2019
20	Adenosine A2A Receptor Mediates Inhibition of Synovitis and Osteoclastogenesis after Electroacupuncture in Rats with Collagen-Induced Arthritis. ( 30956681 )	Du ZH...Ye TS	2019
21	Monoclonal Gammopathy of Undetermined Significance in a Patient With Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis (SAPHO) Syndrome: Coincidence or Association? ( 30870251 )	Horino T...Terada Y	2019
22	Serum levels of proinflammatory, anti-inflammatory cytokines, and RANKL/OPG in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. ( 29694253 )	Zhang S...Zhang W	2019
23	Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study. ( 30767869 )	Li C...Wu Z	2019
24	In finger osteoarthritis, change in synovitis is associated with change in pain on a joint-level; a longitudinal magnetic resonance imaging study. ( 30978394 )	van Beest S...Kloppenburg M	2019
25	Can optical spectral transmission assess ultrasound-detected synovitis in hand osteoarthritis? ( 30794572 )	Besselink NJ...Van Spil WE	2019
26	A Phase 2 Trial of Lutikizumab, an Anti-Interleukin 1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis. ( 30653843 )	Fleischmann RM...Levesque MC	2019
27	Diagnostic performance of knee physical exam and participant-reported symptoms for MRI-detected effusion-synovitis among participants with early or late stage knee osteoarthritis: data from the Osteoarthritis Initiative. ( 30244165 )	Berlinberg A...Kwoh CK	2019
28	Association of Changes in Effusion-Synovitis With Progression of Cartilage Damage Over Eighteen Months in Patients With Osteoarthritis and Meniscal Tear. ( 30133187 )	MacFarlane LA...MeTeOR Investigator Group	2019
29	Can effusion-synovitis measured on ultrasound or MRI predict response to intra-articular steroid injection in hip osteoarthritis? ( 29980827 )	Steer KJD...Jaremko JL	2019
30	Relationship Between Patient-Reported Swelling and Magnetic Resonance Imaging-Defined Effusion-Synovitis in Patients With Meniscus Tears and Knee Osteoarthritis. ( 29726627 )	MacFarlane LA...Meniscal Tear in Osteoarthritis Research Investigator Group	2019
31	Volume of hip synovitis detected on contrast-enhanced magnetic resonance imaging is associated with disease severity after collapse in osteonecrosis of the femoral head. ( 30697641 )	Hatanaka H...Nakashima Y	2019
32	Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee: Complete Synovectomy and Septum Removal-Midterm Results. ( 29727868 )	Keyhani S...Soleymanha M	2019
33	Complications After Total Knee Arthroplasty in Patients With Pigmented Villonodular Synovitis. ( 30266323 )	Casp AJ...Werner BC	2019
34	The effects of radiosynoviorthesis in pigmented villonodular synovitis of the knee. ( 30539286 )	D?rr HR...Tiling R	2019
35	Pigmented Villonodular Synovitis: Novel Role of Dual-Energy CT. ( 30614893 )	Aggarwal A...Junwei Z	2019
36	Atypical Presentation of Pigmented Villonodular Synovitis: A Case Report. ( 30787857 )	AlDakhil MA...Satti MB	2019
37	Osteochondral Lesion in Diffuse Pigmented Villonodular Synovitis of the Knee. ( 30871295 )	Shekhar A...Tapasvi SR	2019
38	Predictive factors associated with the therapeutic response in patients with polymyalgia rheumatica and remitting seronegative symmetrical synovitis with pitting edema syndrome. ( 31064921 )	Tani K...Yamaguchi H	2019
39	Overweight and obesity affect clinical assessment of synovitis in rheumatoid arthritis: comparison of ultrasonography and clinical exam. ( 29998844 )	Goossens J...Ottaviani S	2019
40	IMSYC immunologic synovitis score: A new score for synovial membrane characterization in inflammatory and non-inflammatory arthritis. ( 29709696 )	Najm A...Krenn V	2019
41	Contrast-enhanced MRI compared to direct joint visualization at arthroscopy in pediatric patients with suspected temporomandibular joint synovitis. ( 30382321 )	Leschied JR...Aronovich S	2019
42	Double-inversion recovery with synthetic magnetic resonance: a pilot study for assessing synovitis of the knee joint compared to contrast-enhanced magnetic resonance imaging. ( 30488107 )	Yi J...Suh JS	2019
43	MRI of synovitis and joint fluid. ( 30618151 )	Burke CJ...Regatte RR	2019
44	Histologic assessment of ligament vascularity and synovitis in dogs with cranial cruciate ligament disease. ( 30681360 )	Kuroki K...Cook JL	2019
45	Radioisotope Synoviorthesis in the Control of Refractory Synovitis in Castilla-La Mancha. A 10-year Experience. ( 30691947 )	Castro Corredor D...Cuadra D?az JL	2019
46	Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis. ( 30728752 )	P?rez-Baos S...Largo R	2019
47	Diagnostic value of diffusion-weighted MRI for imaging synovitis in pediatric patients with inflammatory conditions of the knee joint. ( 30729445 )	Li M...Neubauer H	2019
48	What Role Does Synovitis Play in Craniomandibular Dysfunction (CMD)? A 3T-MRI Study. ( 30754055 )	Stimmer H...Wolff KD	2019
49	Psoriatic Synovitis: Singularity and Potential Clinical Implications. ( 30805340 )	Celis R...Ca?ete JD	2019
50	Synovitis as a concomitant disease in shoulder pathologies. ( 30820695 )	Stahnke K...Scheibel M	2019

Sources

Genes for Synovitis

Genes related to Synovitis (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TNF	Tumor Necrosis Factor	Protein Coding	32.43	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	12695163 11027380 9101513 (more) 9358757 19333931 12463461 9458197 12970463 14513116 8868110 11883975 16076882 18667340 11712048 15479886 12810935 10970078 10361385 1642654 20217662 16205926 16329106 15567814 15150427 16542506 15142275 12928941 8761350 8147132 20181277 17976692 18565244 16855166 20176259 18762862 17143658 15457463 10531073 16839506 16286991 8765007 18582368 12592305 11409111 9246090 17642234 17177994 15946184 15905576 15146409 15986366 18311806 18346273 19565512 8846538 10090156 11212159
2	MMP3	Matrix Metallopeptidase 3	Protein Coding	31.88	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	17425385 17918786 15457463 (more) 11928230 11796404 16205926
3	IL1B	Interleukin 1 Beta	Protein Coding	31.3	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	16205926 9358757 19333931 (more) 1616355 11883975 18565244 15482330 16542506 12472254 9246090 1642654 15479886 1503874
4	CRP	C-Reactive Protein	Protein Coding	31.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	18578976 17918786 9864833 (more) 1704698 18759279 12858458 9771209 15934079 19663194 16670155 10817774 8434246 7679058 18234715 12847674
5	COMP	Cartilage Oligomeric Matrix Protein	Protein Coding	30.95	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11597173 11939326 19177799 (more) 15801028 18578976 15843449 9496157 9627009
6	MMP1	Matrix Metallopeptidase 1	Protein Coding	29.69	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	14613270 19883500 1411581
7	IL6	Interleukin 6	Protein Coding	29.63	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11883975 8356390 12673891 (more) 9590334 17918786 9458197 16286991 15172049 12444174 19189867 16282041 15355745 1642654 16868648 1707461 8846538
8	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	28.64	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	16142858 1932367 10494903 (more) 9101513 7512008 16868648 16286991 9065045 8108662 7500047 15672235 9440147 11883975 9551411
9	TNFSF11	TNF Superfamily Member 11	Protein Coding	28.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	17560137 18311801 15479886 (more) 12429533 15930486 18565244 14677171 17288976
10	IL18	Interleukin 18	Protein Coding	27.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	12379638 14872485 15479886 (more) 12527218 16205926 11879550 14738910 15355745 16282041
11	CD163	CD163 Molecule	Protein Coding	27.62	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	12296867 15146432
12	MMP13	Matrix Metallopeptidase 13	Protein Coding	27.46	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	16891219 19883500 10531073
13	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	26.84	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	10952741 11561109 1386092 (more) 15201939 1829749
14	PRG4	Proteoglycan 4	Protein Coding	26.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15702367
15	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	26.13	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15934126 8596155 18310134 (more) 10090156 14513116 12176805 7902093 11014344
16	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	25.99	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8596155 9973520 12176805 (more) 9183648 11014344 14513116
17	PRSS2	Serine Protease 2	Protein Coding	25.67	GeneCards inferred via : Publications Summaries (show sections)
18	SELE	Selectin E	Protein Coding	25.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	12176805 7547116 14513116
19	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	25.06	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	18311801 14677171 12973279 (more) 12509625 15930486
20	CD68	CD68 Molecule	Protein Coding	17.53	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	7628850

Sources

Variations for Synovitis

Sources

Expression for Synovitis

Search GEO for disease gene expression data for Synovitis.

Sources

Pathways for Synovitis

Pathways related to Synovitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁷ Show member pathways Immune System ⁶⁷ Neutrophil degranulation ⁶⁷	14.05	CD68 CRP CXCL8 ICAM1 IL18 IL1B
2	Cytokine Signaling in Immune system ⁶⁷ Show member pathways Signaling by Interleukins ⁶⁷	13.38	CXCL8 ICAM1 IL18 IL1B IL1RN IL6
3	Allograft rejection ³⁸ ¹ Show member pathways Antigen processing and presentation ³⁸ Asthma ³⁸ Autoimmune thyroid disease ³⁸ CTL Mediated Apoptosis ⁶⁵ Graft-versus-host disease ³⁸ Intestinal immune network for IgA production ³⁸ THC Differentiation Pathway ⁶⁵ Type I diabetes mellitus ³⁸ Viral myocarditis ³⁸	12.93	CXCL8 ICAM1 IL18 IL1B IL6 TNF
4	Degradation of the extracellular matrix ⁶⁷ Show member pathways Collagen degradation ⁶⁷ Extracellular matrix organization ⁶⁷	12.82	COMP ICAM1 MMP1 MMP13 MMP3 PRSS2
5	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁷ Show member pathways Cytosolic DNA-sensing pathway ³⁸ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²³ Negative regulators of RIG-I/MDA5 signaling ⁶⁷ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁷ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁸ TRAF3-dependent IRF activation pathway ⁶⁷ TRAF6 mediated IRF7 activation ⁶⁷ Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors (RLR) ⁶⁶	12.8	CXCL8 IL18 IL1B IL6 TNF
6	NF-kappaB Signaling ⁴	12.62	IL1B IL1RN TNF TNFSF11 VCAM1
7	RANK Signaling in Osteoclasts ⁶⁵ Show member pathways Apoptosis and survival APRIL and BAFF signaling ²³ APRIL Pathway ⁶⁵ BAFF in B-Cell Signaling ⁶⁵ RANK Pathway ⁶⁵ RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway ¹	12.44	ICAM1 TNFRSF11B TNFSF11 VCAM1
8	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁷ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.4	CRP ICAM1 IL1B IL6 TNF
9	IL-17 Family Signaling Pathways ⁶⁶ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁸ Interleukin-17 signaling ⁶⁷ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.4	CXCL8 IL1B IL6 MMP1 MMP13 MMP3
10	Human T-cell leukemia virus 1 infection ³⁸	12.38	ICAM1 IL6 TNF VCAM1
11	Toll Comparative Pathway ⁶⁵ Show member pathways IL-1 Pathway ⁶⁵ Immune response MIF in innate immunity response ²³ iNOS Signaling ⁶⁵ TLR-TRIF Pathway ⁶⁵	12.33	CXCL8 IL1B IL6 TNF
12	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶⁵ Interferon alpha/beta signaling ⁶⁷ Regulation of IFNA signaling ⁶⁷	12.31	CXCL8 IL18 IL1B IL6 TNF
13	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²³ Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²³	12.31	CXCL8 ICAM1 IL1B MMP1 MMP13 MMP3
14	IL-1 Family Signaling Pathways ⁶⁶ Show member pathways Immune response IL-1 signaling pathway ²³ Mucin expression in CF via TLRs, EGFR signaling pathways ²³	12.3	CXCL8 IL18 IL1B IL1RN IL6 TNF
15	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²³ Show member pathways Activation of the AP-1 family of transcription factors ⁶⁷ Immune response Oncostatin M signaling via MAPK in human cells ²³ MAPK Cascade ¹ Oncostatin M Signaling Pathway ¹	12.29	MMP1 MMP13 MMP3 TNFSF11
16	Tuberculosis ³⁸	12.28	IL18 IL1B IL6 TNF
17	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.26	CXCL8 IL1B IL1RN IL6 TNF
18	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	12.24	CXCL8 IL1B IL6 TNF
19	Fluid shear stress and atherosclerosis ³⁸	12.18	ICAM1 IL1B SELE TNF VCAM1
20	Immune response IFN gamma signaling pathway ²³ Show member pathways IFN-gamma pathway ¹	12.13	CXCL8 ICAM1 IL18 IL1B IL6
21	Microglia Activation During Neuroinflammation: Overview ⁶⁶ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁶	12.13	IL1B IL6 MMP3 PRSS2 TNF
22	Th1 Differentiation Pathway ⁶⁶ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁶	12.11	IL18 IL1B IL6 TNF
23	Osteoclast differentiation ³⁸	12.1	IL1B TNF TNFRSF11B TNFSF11
24	Spinal Cord Injury ¹	12.1	CXCL8 ICAM1 IL1B IL6 TNF
25	Adhesion ⁴	12.08	ICAM1 MMP13 MMP3 VCAM1
26	TNF signaling pathway ³⁸	12.06	ICAM1 IL1B IL6 MMP3 SELE TNF
27	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	12.05	CD163 CD68 IL6 TNF
28	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁷ Inhibition of Matrix Metalloproteinases ⁶⁵	12.01	MMP1 MMP13 MMP3 PRSS2 TNF
29	NF-kappa B signaling pathway ³⁸	11.99	CXCL8 ICAM1 IL1B TNF TNFSF11 VCAM1
30	AGE-RAGE signaling pathway in diabetic complications ³⁸	11.98	CXCL8 ICAM1 IL1B IL6 SELE TNF
31	Interleukin-4 and 13 signaling ⁶⁷	11.97	CXCL8 ICAM1 IL18 IL1B IL6 MMP1
32	Amoebiasis ³⁸	11.96	CXCL8 IL1B IL6 TNF
33	Salmonella infection (KEGG) ³⁸	11.9	CXCL8 IL18 IL1B IL6
34	Glucocorticoid receptor regulatory network ¹	11.9	CXCL8 ICAM1 IL6 MMP1 SELE
35	Cytokine production by Th17 cells in CF (Mouse model) ²³ Show member pathways Cytokine production by Th17 cells in CF ²³	11.88	CXCL8 ICAM1 IL6
36	Pertussis ³⁸	11.84	CXCL8 IL1B IL6 TNF
37	Dendritic Cells Developmental Lineage Pathway ⁶⁶	11.83	CD163 IL1B IL6 TNF
38	Innate Lymphoid Cell Differentiation Pathways ⁶⁶	11.81	IL18 IL1B TNF
39	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁶	11.77	CD163 CD68 IL18 IL1B IL1RN IL6
40	Lung fibrosis ¹	11.76	CXCL8 IL1B IL6 TNF
41	Cell adhesion_ECM remodeling ²³	11.74	CXCL8 MMP1 MMP13 MMP3
42	Legionellosis ³⁸	11.69	CXCL8 IL18 IL1B IL6 TNF
43	ATF-2 transcription factor network ¹	11.64	CXCL8 IL6 SELE
44	Interleukin-10 signaling ⁶⁷	11.64	CXCL8 ICAM1 IL18 IL1B IL1RN IL6
45	Hepatitis C and Hepatocellular Carcinoma ¹	11.61	CXCL8 IL6 MMP1
46	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	11.59	IL1B IL6 TNF TNFRSF11B TNFSF11
47	amb2 Integrin signaling ¹	11.58	ICAM1 IL6 TNF
48	MSP-RON Signaling ⁶⁵	11.57	IL18 IL1B TNF
49	Thromboxane A2 receptor signaling ¹	11.54	ICAM1 SELE VCAM1
50	Immune response_Role of integrins in NK cells cytotoxicity ²³	11.53	CXCL8 ICAM1 VCAM1

Sources

GO Terms for Synovitis

Cellular components related to Synovitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.86	CD163 COMP CRP CXCL8 IL18 IL1B
2	extracellular matrix	GO:0031012	9.63	COMP MMP1 MMP13 MMP3 PRSS2 TNFRSF11B
3	extracellular space	GO:0005615	9.53	COMP CRP CXCL8 ICAM1 IL18 IL1B

Biological processes related to Synovitis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	9.98	IL1B IL1RN TNF TNFSF11
2	response to lipopolysaccharide	GO:0032496	9.97	ICAM1 IL1B SELE VCAM1
3	extracellular matrix organization	GO:0030198	9.97	COMP ICAM1 TNF TNFRSF11B VCAM1
4	immune response	GO:0006955	9.97	CXCL8 IL18 IL1B IL1RN IL6 PRG4
5	leukocyte migration	GO:0050900	9.95	ICAM1 IL1B MMP1 SELE TNF
6	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.91	IL1B IL6 TNF TNFSF11
7	calcium-mediated signaling	GO:0019722	9.89	CXCL8 SELE TNFSF11
8	neutrophil chemotaxis	GO:0030593	9.89	CXCL8 IL1B IL1RN
9	cellular response to organic cyclic compound	GO:0071407	9.88	IL18 IL1B TNF
10	positive regulation of JNK cascade	GO:0046330	9.88	IL1B IL1RN TNF TNFSF11
11	cellular response to lipopolysaccharide	GO:0071222	9.88	CXCL8 ICAM1 IL1B IL1RN IL6 TNF
12	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.87	TNF TNFRSF11B TNFSF11
13	positive regulation of T cell proliferation	GO:0042102	9.87	IL1B IL6 VCAM1
14	positive regulation of smooth muscle cell proliferation	GO:0048661	9.86	IL18 IL6 TNF
15	regulation of signaling receptor activity	GO:0010469	9.86	CXCL8 IL18 IL1B IL1RN IL6 TNF
16	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.85	IL18 IL1B TNF
17	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO:0007157	9.83	ICAM1 SELE VCAM1
18	positive regulation of interferon-gamma production	GO:0032729	9.82	IL18 IL1B TNF
19	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.82	ICAM1 IL1B TNF
20	regulation of cell adhesion	GO:0030155	9.81	CXCL8 ICAM1 IL18
21	extracellular matrix disassembly	GO:0022617	9.81	MMP1 MMP13 MMP3 PRSS2
22	acute-phase response	GO:0006953	9.8	CD163 CRP IL6
23	positive regulation of interleukin-6 production	GO:0032755	9.8	IL1B IL1RN IL6 TNF
24	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.8	ICAM1 IL18 IL1B IL6 TNF TNFSF11
25	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.79	IL18 IL1B TNF
26	leukocyte cell-cell adhesion	GO:0007159	9.77	ICAM1 SELE VCAM1
27	negative regulation of neurogenesis	GO:0050768	9.77	IL1B IL6 TNF
28	collagen catabolic process	GO:0030574	9.76	MMP1 MMP13 MMP3 PRSS2
29	leukocyte tethering or rolling	GO:0050901	9.73	SELE TNF VCAM1
30	negative regulation of bone resorption	GO:0045779	9.71	IL6 TNFRSF11B
31	growth plate cartilage development	GO:0003417	9.71	COMP MMP13
32	neutrophil activation	GO:0042119	9.71	CXCL8 IL18
33	positive regulation of glial cell proliferation	GO:0060252	9.71	IL1B IL6 TNF
34	positive regulation of granulocyte macrophage colony-stimulating factor production	GO:0032725	9.7	IL18 IL1B
35	positive regulation of chemokine biosynthetic process	GO:0045080	9.7	IL1B TNF
36	response to glucocorticoid	GO:0051384	9.7	IL1RN IL6 TNF
37	interleukin-6 production	GO:0032635	9.69	IL18 IL1B
38	regulation of establishment of endothelial barrier	GO:1903140	9.69	IL1B TNF
39	positive regulation of leukocyte adhesion to vascular endothelial cell	GO:1904996	9.68	ICAM1 TNF
40	response to hypoxia	GO:0001666	9.67	ICAM1 VCAM1
41	membrane to membrane docking	GO:0022614	9.67	ICAM1 VCAM1
42	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.66	IL1RN IL6
43	positive regulation of fever generation	GO:0031622	9.66	IL1B TNF
44	positive regulation of T-helper 1 cell cytokine production	GO:2000556	9.65	IL18 IL1B
45	negative regulation of lipid storage	GO:0010888	9.65	CRP IL6 TNF
46	sequestering of triglyceride	GO:0030730	9.63	IL1B TNF
47	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.61	IL1B TNF
48	inflammatory response	GO:0006954	9.61	CD163 CRP CXCL8 IL18 IL1B IL1RN
49	positive regulation of neuroinflammatory response	GO:0150078	9.46	IL18 IL1B IL6 TNF
50	cytokine-mediated signaling pathway	GO:0019221	9.36	CXCL8 ICAM1 IL18 IL1B IL1RN IL6

Molecular functions related to Synovitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase activity	GO:0004252	9.33	MMP1 MMP3 PRSS2
2	cytokine activity	GO:0005125	9.23	CXCL8 IL18 IL1B IL1RN IL6 TNF
3	metalloendopeptidase activity	GO:0004222	9.13	MMP1 MMP13 MMP3

Sources

Sources for Synovitis

¹ BioSystems

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⁴⁹ NCBI Bookshelf

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⁵⁶ Novoseek

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⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

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⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia