MCID: SYN008
MIFTS: 22

Synovium Cancer

Categories: Cancer diseases

Aliases & Classifications for Synovium Cancer

MalaCards integrated aliases for Synovium Cancer:

Name: Synovium Cancer 12 15
Malignant Tumor of Synovium 12
Synovial Neoplasm 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2706
NCIt 50 C6531
UMLS 70 C0476203 C1334624

Summaries for Synovium Cancer

MalaCards based summary : Synovium Cancer, also known as malignant tumor of synovium, is related to sarcoma, synovial and tibial adamantinoma. An important gene associated with Synovium Cancer is CFAP47 (Cilia And Flagella Associated Protein 47), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Synovium Cancer

Diseases related to Synovium Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 sarcoma, synovial 30.1 TLE1 SSX4B SSX4 SSX2 SSX1 SS18
2 tibial adamantinoma 10.5 TLE1 SSX1
3 adamantinoma of long bones 10.5 TLE1 SSX1
4 meninges sarcoma 10.5 SSX2 SS18
5 cellular neurofibroma 10.5 TLE1 SMARCB1
6 spindle cell liposarcoma 10.5 TLE1 CD34
7 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.5 EWSR1 CD99
8 intracranial primitive neuroectodermal tumor 10.5 EWSR1 CD99
9 central nervous system angiosarcoma 10.5 SMARCB1 CD34
10 extraskeletal mesenchymal chondrosarcoma 10.5 EWSR1 CD99
11 bone angioendothelial sarcoma 10.5 SSX4B SSX4 SS18
12 pulmonary vein leiomyosarcoma 10.5 CD99 CD34
13 extraskeletal chondroma 10.5 SERPINA3 EWSR1
14 thymic epithelial tumor 10.5 KIT CD99
15 spermatic cord cancer 10.4 SSX2 SSX1 CD34
16 kidney hemangiopericytoma 10.4 SSX2 SS18 CD34
17 spinal cord sarcoma 10.4 KIT CD34
18 malignant glandular tumor of peripheral nerve sheath 10.4 TLE1 SSX2 SMARCB1
19 ewing sarcoma of bone 10.4 EWSR1 CD99
20 gallbladder leiomyoma 10.4 KIT CD34
21 adult fibrosarcoma 10.4 SSX1 CD34
22 small intestine leiomyosarcoma 10.4 KIT CD34
23 neuronal intestinal dysplasia, type b 10.4 KIT CD34
24 gastric liposarcoma 10.4 KIT CD34
25 mucocele of appendix 10.4 KIT CD34
26 pineal region teratoma 10.4 SMARCB1 KIT
27 meninges hemangiopericytoma 10.4 CD99 CD34
28 epidural spinal canal neoplasm 10.4 CD99 CD34
29 proliferative fasciitis 10.4 SMARCB1 SERPINA3
30 cellular congenital mesoblastic nephroma 10.4 TLE1 SSX2 CCNB3
31 peripheral nerve schwannoma 10.4 SMARCB1 SERPINA3
32 kidney cortex disease 10.4 SSX2 SS18 CCNB3
33 gallbladder leiomyosarcoma 10.4 KIT CD34
34 deep leiomyoma 10.4 KIT CD34
35 small cell sarcoma 10.4 EWSR1 CCNB3
36 small intestinal sarcoma 10.4 KIT EWSR1
37 angiomyoma 10.4 KIT CD34
38 benign fibrous mesothelioma 10.4 KIT CD34
39 subungual glomus tumor 10.4 TLE1 CD34
40 retroperitoneal hemangiopericytoma 10.4 KIT CD34
41 breast leiomyosarcoma 10.4 KIT CD34
42 malignant mesenchymoma 10.4 SSX2 SERPINA3 CD34
43 testicular fibroma 10.4 CD99 CD34
44 extraosseous osteosarcoma 10.4 SSX1 CD34
45 olfactory nerve neoplasm 10.4 SMARCB1 EWSR1 CD99
46 cranial nerve malignant neoplasm 10.4 SMARCB1 EWSR1 CD99
47 vulvar sarcoma 10.4 SMARCB1 EWSR1 CD34
48 cranial nerve neoplasm 10.4 SMARCB1 EWSR1 CD99
49 colon leiomyosarcoma 10.4 KIT CD34
50 mediastinal mesenchymal tumor 10.4 TLE1 SSX4B SSX4 SS18

Graphical network of the top 20 diseases related to Synovium Cancer:



Diseases related to Synovium Cancer

Symptoms & Phenotypes for Synovium Cancer

GenomeRNAi Phenotypes related to Synovium Cancer according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.75 H2AC18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 9.75 TLE1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.75 TLE1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 9.75 EWSR1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.75 EWSR1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.75 H2AC18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-140 9.75 EWSR1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.75 EWSR1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.75 H2AC18
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.75 H2AC18
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-183 9.75 TLE1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.75 EWSR1 H2AC18
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.75 SSX1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.75 H2AC18
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 9.75 H2AC18
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.75 EWSR1 SSX1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.75 EWSR1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-76 9.75 SSX2
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.75 EWSR1
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.75 EWSR1 SSX2
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.75 EWSR1

Drugs & Therapeutics for Synovium Cancer

Search Clinical Trials , NIH Clinical Center for Synovium Cancer

Genetic Tests for Synovium Cancer

Anatomical Context for Synovium Cancer

Publications for Synovium Cancer

Articles related to Synovium Cancer:

# Title Authors PMID Year
1
Subcutaneous pigmented villonodular synovitis caused by portal contamination during knee arthroscopy and open synovectomy. 61
15067291 2004
2
Synovial chondromatosis: a case study and brief review. 61
9021034 1997
3
[Diagnosis and treatment of lateral crypta synovial crush syndrome of knee]. 61
8731887 1995
4
Primary synovial chondromatosis of the ankle. A case report. 61
956234 1976

Variations for Synovium Cancer

Expression for Synovium Cancer

Search GEO for disease gene expression data for Synovium Cancer.

Pathways for Synovium Cancer

Pathways related to Synovium Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.3 SSX2 SSX1 SS18 PAX3 EWSR1
2 11.11 PAX3 KIT CD34

GO Terms for Synovium Cancer

Cellular components related to Synovium Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 npBAF complex GO:0071564 8.62 SS18 SMARCB1

Biological processes related to Synovium Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.5 TLE1 SSX4B SSX4 SSX2 SSX1 PAX3
2 tRNA threonylcarbamoyladenosine metabolic process GO:0070525 8.62 CTAG1B CTAG1A

Sources for Synovium Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....