MCID: SYN008
MIFTS: 23

Synovium Cancer

Categories: Cancer diseases

Aliases & Classifications for Synovium Cancer

MalaCards integrated aliases for Synovium Cancer:

Name: Synovium Cancer 12 15
Malignant Tumor of Synovium 12
Synovial Neoplasm 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2706
NCIt 51 C6531

Summaries for Synovium Cancer

MalaCards based summary : Synovium Cancer, also known as malignant tumor of synovium, is related to sarcoma, synovial and kidney rhabdoid cancer. An important gene associated with Synovium Cancer is SSX1 (SSX Family Member 1), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and Transcriptional misregulation in cancer. Affiliated tissues include kidney, skin and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Synovium Cancer

Graphical network of the top 20 diseases related to Synovium Cancer:



Diseases related to Synovium Cancer

Symptoms & Phenotypes for Synovium Cancer

GenomeRNAi Phenotypes related to Synovium Cancer according to GeneCards Suite gene sharing:

27 (show all 46)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.23 SSX2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.23 EWSR1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.23 TLE1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.23 TLE1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.23 SSX1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.23 EWSR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.23 TLE1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.23 EWSR1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.23 EWSR1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.23 EWSR1 TLE1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.23 TLE1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.23 SSX1 SSX2 SSX4 SSX4B SSX3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.23 EWSR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.23 EWSR1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.23 TLE1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.23 EWSR1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.23 SSX4 SSX4B SSX3
18 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.23 SSX1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.23 SSX2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.23 EWSR1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.23 TBC1D25
22 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.23 SSX3
23 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.23 SSX4 SSX4B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.23 TBC1D25
25 Increased shRNA abundance (Z-score > 2) GR00366-A-51 10.23 SSX4 SSX4B
26 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.23 EWSR1 SSX1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.23 SSX1 TLE1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.23 SSX4 SSX4B
29 Increased shRNA abundance (Z-score > 2) GR00366-A-76 10.23 SSX2 SSX3
30 Increased shRNA abundance (Z-score > 2) GR00366-A-78 10.23 SSX3
31 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.23 EWSR1 SSX2
32 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.23 TLE1 SSX4 SSX4B TBC1D25
33 Increased shRNA abundance (Z-score > 2) GR00366-A-92 10.23 SSX3
34 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.23 EWSR1
35 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 10.03 SSX4 SSX4B
36 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 10.03 SSX3 SSX4 SSX4B
37 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 10.03 EWSR1
38 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.03 EWSR1
39 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 10.03 TBC1D25
40 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 10.03 TBC1D25
41 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.03 SSX4 SSX4B EWSR1 TBC1D25
42 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 10.03 TBC1D25
43 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 10.03 TBC1D25
44 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 10.03 EWSR1
45 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.03 EWSR1
46 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 10.03 EWSR1

Drugs & Therapeutics for Synovium Cancer

Search Clinical Trials , NIH Clinical Center for Synovium Cancer

Genetic Tests for Synovium Cancer

Anatomical Context for Synovium Cancer

MalaCards organs/tissues related to Synovium Cancer:

42
Kidney, Skin, Bone

Publications for Synovium Cancer

Variations for Synovium Cancer

Expression for Synovium Cancer

Search GEO for disease gene expression data for Synovium Cancer.

Pathways for Synovium Cancer

Pathways related to Synovium Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.54 EWSR1 SMARCB1 SS18
2 11.19 EWSR1 SS18 SSX1 SSX2

GO Terms for Synovium Cancer

Cellular components related to Synovium Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.72 SSX1 SSX2 SSX3 SSX4 SSX4B
2 SWI/SNF complex GO:0016514 9.16 SMARCB1 SS18
3 nBAF complex GO:0071565 8.96 SMARCB1 SS18L1
4 npBAF complex GO:0071564 8.62 SMARCB1 SS18
5 nucleus GO:0005634 10 CCNB3 EWSR1 SMARCB1 SS18 SS18L1 SSX1

Biological processes related to Synovium Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.17 EWSR1 SSX1 SSX2 SSX3 SSX4 SSX4B

Sources for Synovium Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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