MCID: SYN008
MIFTS: 28

Synovium Cancer

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Synovium Cancer

MalaCards integrated aliases for Synovium Cancer:

Name: Synovium Cancer 12 15
Synovial Neoplasm 12 73
Synovial Cancer 76 53
Malignant Tumor of Synovium 12
Synovium Neoplasm 12
Tumor of Synovium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2706 DOID:315
NCIt 50 C6531 C8964
SNOMED-CT 68 189829008 189831004

Summaries for Synovium Cancer

MalaCards based summary : Synovium Cancer, also known as synovial neoplasm, is related to sarcoma, synovial and nodular tenosynovitis. An important gene associated with Synovium Cancer is SSX1 (SSX Family Member 1), and among its related pathways/superpathways is Transcriptional misregulation in cancer. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 A synovial sarcoma (also known as: malignant synovioma) is a rare form of cancer which occurs primarily... more...

Related Diseases for Synovium Cancer

Diseases related to Synovium Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 sarcoma, synovial 28.4 HEATR3 SS18 SSX1 SSX2B SSX3 SSX4
2 nodular tenosynovitis 11.0
3 epithelioid cell synovial sarcoma 10.7 SSX1 SSX2B
4 extraskeletal mesenchymal chondrosarcoma 10.6 SSX1 SSX2B
5 kidney rhabdoid cancer 10.6 EWSR1 SMARCB1
6 extraosseous chondrosarcoma 10.6 EWSR1 SMARCB1
7 biphasic synovial sarcoma 10.5 EWSR1 HEATR3 SSX1
8 tibial adamantinoma 10.4 CD34 SSX1
9 bone epithelioid hemangioma 10.4 CD34 EWSR1
10 lung sarcoma 10.3 EWSR1 SSX2B
11 vulvar sarcoma 10.1 CD34 EWSR1 SMARCB1
12 malignant mesenchymoma 10.1 EWSR1 SSX2B
13 mesenchymal cell neoplasm 10.1 CD34 EWSR1 SMARCB1
14 nervous system cancer 10.1 CD34 EWSR1 SMARCB1
15 giant cell tumor 10.0
16 pigmented villonodular synovitis 10.0
17 synovitis 10.0
18 villonodular synovitis 10.0
19 myoepithelioma 9.9 EWSR1 SMARCB1
20 kidney hemangiopericytoma 9.9 CD34 SS18 SSX2B
21 malignant giant cell tumor 9.9
22 nephrogenic adenofibroma 9.9 CD34 SS18
23 meninges sarcoma 9.7 CD34 CREB3L2
24 sclerosing liposarcoma 9.7 CD34 CREB3L2
25 deep angioma 9.6 CD34 CREB3L2
26 conventional fibrosarcoma 9.6 CD34 CREB3L2
27 mixed liposarcoma 9.6 CD34 CREB3L2
28 intramuscular hemangioma 9.6 CD34 CREB3L2
29 infiltrating lipoma 9.5 CD34 CREB3L2
30 pleomorphic lipoma 9.5 CD34 CREB3L2
31 skin sarcoma 9.5 CD34 CREB3L2 EWSR1
32 muscle cancer 9.4 CD34 CREB3L2 EWSR1
33 chondrosarcoma, extraskeletal myxoid 9.3 CREB3L2 EWSR1 SMARCB1 SS18
34 spindle cell liposarcoma 9.0 CD34 CREB3L2 SMARCB1 TLE1
35 spindle cell synovial sarcoma 8.8 CD34 SMARCB1 SS18 SSX1 SSX2B TLE1
36 sarcoma 7.5 CREB3L2 EWSR1 SS18 SSX1 SSX2B SSX3
37 connective tissue cancer 7.3 CD34 CREB3L2 EWSR1 HEATR3 SMARCB1 SS18

Graphical network of the top 20 diseases related to Synovium Cancer:



Diseases related to Synovium Cancer

Symptoms & Phenotypes for Synovium Cancer

GenomeRNAi Phenotypes related to Synovium Cancer according to GeneCards Suite gene sharing:

26 (show all 41)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 10.27 TLE1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 10.27 SSX4B SSX4
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 10.27 SSX4B SSX2B SSX3 SSX4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 10.27 SSX2B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 10.27 EWSR1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 10.27 SSX1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.27 EWSR1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 10.27 TBC1D25
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 10.27 TBC1D25
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.27 SSX4 SSX4B EWSR1 TBC1D25
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 10.27 TBC1D25
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.27 TLE1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 10.27 TBC1D25
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 10.27 SSX2B EWSR1 SSX1 TLE1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.27 EWSR1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 10.27 EWSR1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.05 SSX2B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.05 TLE1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.05 TLE1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.05 SSX1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.05 TLE1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.05 TLE1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.05 TLE1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.05 SSX4 SSX3 SSX4B SSX1 SSX2B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.05 TLE1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.05 SSX4 SSX3 SSX4B SSX2B
27 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.05 SSX1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.05 SSX2B
29 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.05 TBC1D25
30 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.05 SSX2B SSX3
31 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.05 SSX4 SSX4B
32 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.05 TBC1D25
33 Increased shRNA abundance (Z-score > 2) GR00366-A-51 10.05 SSX4 SSX4B
34 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.05 SSX1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.05 SSX1 TLE1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.05 SSX4 SSX4B
37 Increased shRNA abundance (Z-score > 2) GR00366-A-76 10.05 SSX3 SSX2B
38 Increased shRNA abundance (Z-score > 2) GR00366-A-78 10.05 SSX3
39 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.05 SSX2B
40 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.05 SSX4 SSX4B TBC1D25 TLE1
41 Increased shRNA abundance (Z-score > 2) GR00366-A-92 10.05 SSX3

Drugs & Therapeutics for Synovium Cancer

Search Clinical Trials , NIH Clinical Center for Synovium Cancer

Genetic Tests for Synovium Cancer

Anatomical Context for Synovium Cancer

Publications for Synovium Cancer

Articles related to Synovium Cancer:

# Title Authors Year
1
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). ( 11079016 )
2000
2
Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. ( 2545593 )
1989
3
Giant cell tumors of synovium (Pigmented villonodular synovitis) involving the vertebral column. ( 3955510 )
1986

Variations for Synovium Cancer

Cosmic variations for Synovium Cancer:

9
(show all 18)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM43687 TP53 soft tissue,leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
2 COSM11333 TP53 soft tissue,leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
3 COSM4774989 SH2B3 soft tissue,leg,sarcoma,NS c.232G>A p.E78K 12:111418377-111418377 3
4 COSM6954536 NUP93 soft tissue,leg,sarcoma,NS c.116C>T p.A39V 16:56748363-56748363 3
5 COSM2923082 ANKRD11 soft tissue,leg,sarcoma,NS c.2882G>T p.R961L 16:89283660-89283660 3
6 COSM121083 soft tissue,leg,sarcoma,NS c.220C>T p.Q74* 17:7675113-7675113 3
7 COSM1640840 soft tissue,leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
8 COSM307279 soft tissue,leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
9 COSM2744872 soft tissue,leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
10 COSM3937613 soft tissue,leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
11 COSM307282 soft tissue,leg,sarcoma,NS c.362A>G p.H121R 17:7674890-7674890 3
12 COSM121082 soft tissue,leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
13 COSM121084 soft tissue,leg,sarcoma,NS c.103C>T p.Q35* 17:7675113-7675113 3
14 COSM3388198 soft tissue,leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
15 COSM121081 soft tissue,leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
16 COSM307280 soft tissue,leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
17 COSM307281 soft tissue,leg,sarcoma,NS c.245A>G p.H82R 17:7674890-7674890 3
18 COSM480 HRAS soft tissue,lower leg,synovial sarcoma,NS c.34G>A p.G12S 11:534289-534289 2

Expression for Synovium Cancer

Search GEO for disease gene expression data for Synovium Cancer.

Pathways for Synovium Cancer

Pathways related to Synovium Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.19 EWSR1 SS18 SSX1 SSX2B

GO Terms for Synovium Cancer

Cellular components related to Synovium Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.9 CREB3L2 EWSR1 SMARCB1 SS18 SS18L1 SSX1
2 intracellular GO:0005622 9.73 HEATR3 SSX1 SSX2B SSX3 SSX4 SSX4B
3 nBAF complex GO:0071565 8.96 SMARCB1 SS18L1
4 npBAF complex GO:0071564 8.62 SMARCB1 SS18

Biological processes related to Synovium Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.9 CREB3L2 EWSR1 SMARCB1 SS18 SS18L1 SSX1
2 transcription, DNA-templated GO:0006351 9.7 CREB3L2 EWSR1 SMARCB1 SS18 SS18L1 SSX1
3 regulation of nucleic acid-templated transcription GO:1903506 9.26 SS18 SS18L1
4 negative regulation of nucleic acid-templated transcription GO:1903507 9.02 SSX1 SSX2B SSX3 SSX4 SSX4B

Molecular functions related to Synovium Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleic acid binding GO:0003676 9.55 SSX1 SSX2B SSX3 SSX4 SSX4B
2 transcription coregulator activity GO:0003712 9.13 EWSR1 SS18 SS18L1
3 transcription corepressor activity GO:0003714 9.02 SSX1 SSX2B SSX3 SSX4 SSX4B

Sources for Synovium Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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