MCID: SYN009
MIFTS: 19

Synovium Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Synovium Neoplasm

MalaCards integrated aliases for Synovium Neoplasm:

Name: Synovium Neoplasm 12 15
Synovial Neoplasm 12
Tumor of Synovium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:315
NCIt 49 C8964
UMLS 71 C0476203

Summaries for Synovium Neoplasm

MalaCards based summary : Synovium Neoplasm, also known as synovial neoplasm, is related to synovium cancer and tendon sheath lipoma. An important gene associated with Synovium Neoplasm is SSX4B (SSX Family Member 4B), and among its related pathways/superpathways are Cytoskeletal Signaling and Transcriptional misregulation in cancer. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Synovium Neoplasm

Diseases related to Synovium Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 synovium cancer 30.3 TLE1 SSX4B SSX4 SSX2 SSX1 SS18
2 tendon sheath lipoma 11.3
3 nodular tenosynovitis 11.3
4 tibial adamantinoma 10.3 TLE1 SSX1
5 adamantinoma of long bones 10.3 TLE1 SSX1
6 congenital mesoblastic nephroma 10.2 SSX4B SSX2
7 cellular schwannoma 10.2 SSX1 SS18
8 malignant glandular tumor of peripheral nerve sheath 10.2 TLE1 SSX2
9 cellular congenital mesoblastic nephroma 10.2 TLE1 SSX2
10 kidney hemangiopericytoma 10.2 SSX2 SS18
11 epithelioid cell synovial sarcoma 10.2 SSX2 SSX1
12 meninges sarcoma 10.2 SSX2 SS18
13 extraosseous chondrosarcoma 10.2 SSX1 SS18
14 spermatic cord cancer 10.2 SSX2 SSX1
15 heart sarcoma 10.2 SSX2 SSX1
16 lung sarcoma 10.2 SSX2 SSX1
17 kidney clear cell sarcoma 10.2 TLE1 SSX1
18 cellular myxoid liposarcoma 10.2 SSX2 SS18
19 plica syndrome 10.1
20 pigmented villonodular synovitis 10.1
21 synovitis 10.1
22 villonodular synovitis 10.1
23 bone angioendothelial sarcoma 10.1 SSX4B SSX4 SS18
24 pseudosarcomatous fibromatosis 10.1 SS18 AKTIP
25 malignant giant cell tumor 10.1
26 rhabdoid cancer 10.0 SSX2 SS18
27 supine hypotensive syndrome 10.0 KRT7 AKTIP
28 kidney sarcoma 10.0 TLE1 SSX2 SS18
29 epithelioid malignant peripheral nerve sheath tumor 10.0 TLE1 SSX2 SS18
30 myxofibrosarcoma 10.0 TLE1 SSX2 SS18
31 proliferating trichilemmal cyst 10.0 KRT8 KRT7
32 bladder clear cell adenocarcinoma 10.0 KRT7 EHD1
33 endolymphatic sac tumor 10.0 KRT8 KRT7
34 subareolar duct papillomatosis 10.0 KRT8 KRT7
35 pancreatic serous cystic neoplasm 10.0 KRT8 EHD1
36 nipple benign neoplasm 10.0 KRT8 KRT7
37 benign breast adenomyoepithelioma 9.9 KRT8 KRT7
38 skeletal muscle cancer 9.9 SSX2 SSX1 SS18
39 muscle cancer 9.9 SSX2 SSX1 SS18
40 intrahepatic gall duct cancer 9.9 KRT8 KRT7
41 squamous cell bile duct carcinoma 9.9 KRT8 KRT7
42 dedifferentiated liposarcoma 9.9 SSX2 SSX1 SS18
43 hidrocystoma 9.9 KRT8 KRT7
44 rhabdomyosarcoma 2 9.9 SSX2 SSX1 SS18
45 eccrine sweat gland neoplasm 9.9 KRT8 KRT7
46 myxoid liposarcoma 9.9 SSX2 SSX1 SS18
47 sarcomatous intrahepatic cholangiocarcinoma 9.9 KRT8 KRT7
48 eccrine papillary adenocarcinoma 9.9 KRT8 KRT7
49 cutaneous adenocystic carcinoma 9.9 KRT8 KRT7
50 mucinous tubular and spindle renal cell carcinoma 9.9 KRT8 KRT7

Graphical network of the top 20 diseases related to Synovium Neoplasm:



Diseases related to Synovium Neoplasm

Symptoms & Phenotypes for Synovium Neoplasm

GenomeRNAi Phenotypes related to Synovium Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 9.47 TLE1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.47 TLE1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-183 9.47 TLE1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.47 SSX1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.47 SSX1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-76 9.47 SSX2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.47 SSX2

Drugs & Therapeutics for Synovium Neoplasm

Search Clinical Trials , NIH Clinical Center for Synovium Neoplasm

Genetic Tests for Synovium Neoplasm

Anatomical Context for Synovium Neoplasm

Publications for Synovium Neoplasm

Articles related to Synovium Neoplasm:

# Title Authors PMID Year
1
Synovial hemangiomas of wrist and ankle joint: A report of two rare cases. 61
30303163 2018
2
Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors. 61
12447678 2002
3
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). 61
11079016 2000
4
[Primary study of histogenesis and diagnosis of synoviosarcoma]. 61
2560460 1989
5
Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. 61
2545593 1989
6
[Tumors and tumor-like lesions of the hand]. 61
914105 1977

Variations for Synovium Neoplasm

Expression for Synovium Neoplasm

Search GEO for disease gene expression data for Synovium Neoplasm.

Pathways for Synovium Neoplasm

Pathways related to Synovium Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 KRT8 KRT7 FLNA
2 11.08 SSX2 SSX1 SS18

GO Terms for Synovium Neoplasm

Cellular components related to Synovium Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.32 TLE1 SSX4B SSX4 SSX2 SSX1 SS18

Sources for Synovium Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....