MCID: SYN009
MIFTS: 18

Synovium Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Synovium Neoplasm

MalaCards integrated aliases for Synovium Neoplasm:

Name: Synovium Neoplasm 12 15
Synovial Neoplasm 12
Tumor of Synovium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:315
NCIt 50 C8964
SNOMED-CT 67 189829008
UMLS 71 C0476203

Summaries for Synovium Neoplasm

MalaCards based summary : Synovium Neoplasm, also known as synovial neoplasm, is related to synovium cancer and nodular tenosynovitis. An important gene associated with Synovium Neoplasm is SSX4B (SSX Family Member 4B), and among its related pathways/superpathways is Transcriptional misregulation in cancer. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Synovium Neoplasm

Diseases related to Synovium Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 synovium cancer 29.9 TLE1 SSX4B SSX4 SSX2 SSX1 SS18
2 nodular tenosynovitis 11.2
3 tendon sheath lipoma 11.1
4 tibial adamantinoma 10.1 TLE1 SSX1
5 adamantinoma of long bones 10.1 TLE1 SSX1
6 plica syndrome 10.1
7 pigmented villonodular synovitis 10.1
8 synovitis 10.1
9 malignant giant cell tumor 10.1
10 villonodular synovitis 10.1
11 congenital mesoblastic nephroma 10.1 SSX4B SSX2
12 cellular schwannoma 10.1 SSX1 SS18
13 malignant glandular tumor of peripheral nerve sheath 10.1 TLE1 SSX2
14 cellular congenital mesoblastic nephroma 10.0 TLE1 SSX2
15 kidney hemangiopericytoma 10.0 SSX2 SS18
16 meninges sarcoma 10.0 SSX2 SS18
17 bone angioendothelial sarcoma 10.0 SSX4B SSX4 SS18
18 spermatic cord cancer 10.0 SSX2 SSX1
19 heart sarcoma 10.0 SSX2 SSX1
20 extraosseous chondrosarcoma 10.0 SSX2 SS18
21 lung sarcoma 10.0 SSX2 SSX1
22 kidney fibrosarcoma 10.0 SSX2 SSX1
23 malignant fibrous histiocytoma 9.9
24 fibrous histiocytoma 9.9
25 proliferating trichilemmal cyst 9.9 KRT8 KRT7
26 endolymphatic sac tumor 9.9 KRT8 KRT7
27 subareolar duct papillomatosis 9.9 KRT8 KRT7
28 nipple benign neoplasm 9.9 KRT8 KRT7
29 benign breast adenomyoepithelioma 9.9 KRT8 KRT7
30 intrahepatic gall duct cancer 9.9 KRT8 KRT7
31 rhabdoid cancer 9.9 SSX2 SS18
32 squamous cell bile duct carcinoma 9.9 KRT8 KRT7
33 hidrocystoma 9.9 KRT8 KRT7
34 eccrine papillary adenocarcinoma 9.9 KRT8 KRT7
35 sarcomatous intrahepatic cholangiocarcinoma 9.9 KRT8 KRT7
36 cutaneous adenocystic carcinoma 9.9 KRT8 KRT7
37 mucinous tubular and spindle renal cell carcinoma 9.9 KRT8 KRT7
38 breast osteosarcoma 9.9 KRT8 KRT7
39 apocrine sweat gland neoplasm 9.9 KRT8 KRT7
40 adenoid squamous cell carcinoma 9.8 KRT8 KRT7
41 uterus leiomyosarcoma 9.8 KRT8 KRT7
42 uterine corpus sarcoma 9.8 KRT8 KRT7
43 intraductal breast benign neoplasm 9.8 KRT8 KRT7
44 breast benign neoplasm 9.8 KRT8 KRT7
45 cribriform carcinoma 9.8 KRT8 KRT7
46 eccrine papillary adenoma 9.8 KRT8 KRT7
47 sweat gland benign neoplasm 9.8 KRT8 KRT7
48 lymphoepithelioma-like carcinoma 9.8 KRT8 KRT7
49 pleomorphic carcinoma 9.8 KRT8 KRT7
50 epithelioid malignant peripheral nerve sheath tumor 9.8 TLE1 SSX2 SS18

Graphical network of the top 20 diseases related to Synovium Neoplasm:



Diseases related to Synovium Neoplasm

Symptoms & Phenotypes for Synovium Neoplasm

GenomeRNAi Phenotypes related to Synovium Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 9.55 TLE1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.55 TLE1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-183 9.55 TLE1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.55 SSX1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.55 SSX1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.55 KRT8
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.55 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-76 9.55 SSX2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.55 SSX2

Drugs & Therapeutics for Synovium Neoplasm

Search Clinical Trials , NIH Clinical Center for Synovium Neoplasm

Genetic Tests for Synovium Neoplasm

Anatomical Context for Synovium Neoplasm

Publications for Synovium Neoplasm

Articles related to Synovium Neoplasm:

# Title Authors PMID Year
1
Synovial hemangiomas of wrist and ankle joint: A report of two rare cases. 61
30303163 2018
2
Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors. 61
12447678 2002
3
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). 61
11079016 2000
4
[Primary study of histogenesis and diagnosis of synoviosarcoma]. 61
2560460 1989
5
Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. 61
2545593 1989
6
[Tumors and tumor-like lesions of the hand]. 61
914105 1977

Variations for Synovium Neoplasm

Expression for Synovium Neoplasm

Search GEO for disease gene expression data for Synovium Neoplasm.

Pathways for Synovium Neoplasm

Pathways related to Synovium Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.08 SSX2 SSX1 SS18

GO Terms for Synovium Neoplasm

Cellular components related to Synovium Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.23 TLE1 SSX4B SSX4 SSX2 SSX1 SS18

Biological processes related to Synovium Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.02 TLE1 SSX4B SSX4 SSX2 SSX1

Molecular functions related to Synovium Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleic acid binding GO:0003676 8.92 SSX4B SSX4 SSX2 SSX1

Sources for Synovium Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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