Synovium Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Synovium Neoplasm

MalaCards integrated aliases for Synovium Neoplasm:

Name: Synovium Neoplasm ¹² ¹⁵

Synovial Neoplasm ¹²

Tumor of Synovium ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:315

NCIt ⁴⁹ C8964

UMLS ⁷¹ C0476203

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Summaries for Synovium Neoplasm

MalaCards based summary : Synovium Neoplasm, also known as synovial neoplasm, is related to synovium cancer and tendon sheath lipoma. An important gene associated with Synovium Neoplasm is SSX4B (SSX Family Member 4B), and among its related pathways/superpathways are Cytoskeletal Signaling and Transcriptional misregulation in cancer. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Synovium Neoplasm

Diseases related to Synovium Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)

#	Related Disease	Score	Top Affiliating Genes
1	synovium cancer	30.3	TLE1 SSX4B SSX4 SSX2 SSX1 SS18
2	tendon sheath lipoma	11.3
3	nodular tenosynovitis	11.3
4	tibial adamantinoma	10.3	TLE1 SSX1
5	adamantinoma of long bones	10.3	TLE1 SSX1
6	congenital mesoblastic nephroma	10.2	SSX4B SSX2
7	cellular schwannoma	10.2	SSX1 SS18
8	malignant glandular tumor of peripheral nerve sheath	10.2	TLE1 SSX2
9	cellular congenital mesoblastic nephroma	10.2	TLE1 SSX2
10	kidney hemangiopericytoma	10.2	SSX2 SS18
11	epithelioid cell synovial sarcoma	10.2	SSX2 SSX1
12	meninges sarcoma	10.2	SSX2 SS18
13	extraosseous chondrosarcoma	10.2	SSX1 SS18
14	spermatic cord cancer	10.2	SSX2 SSX1
15	heart sarcoma	10.2	SSX2 SSX1
16	lung sarcoma	10.2	SSX2 SSX1
17	kidney clear cell sarcoma	10.2	TLE1 SSX1
18	cellular myxoid liposarcoma	10.2	SSX2 SS18
19	plica syndrome	10.1
20	pigmented villonodular synovitis	10.1
21	synovitis	10.1
22	villonodular synovitis	10.1
23	bone angioendothelial sarcoma	10.1	SSX4B SSX4 SS18
24	pseudosarcomatous fibromatosis	10.1	SS18 AKTIP
25	malignant giant cell tumor	10.1
26	rhabdoid cancer	10.0	SSX2 SS18
27	supine hypotensive syndrome	10.0	KRT7 AKTIP
28	kidney sarcoma	10.0	TLE1 SSX2 SS18
29	epithelioid malignant peripheral nerve sheath tumor	10.0	TLE1 SSX2 SS18
30	myxofibrosarcoma	10.0	TLE1 SSX2 SS18
31	proliferating trichilemmal cyst	10.0	KRT8 KRT7
32	bladder clear cell adenocarcinoma	10.0	KRT7 EHD1
33	endolymphatic sac tumor	10.0	KRT8 KRT7
34	subareolar duct papillomatosis	10.0	KRT8 KRT7
35	pancreatic serous cystic neoplasm	10.0	KRT8 EHD1
36	nipple benign neoplasm	10.0	KRT8 KRT7
37	benign breast adenomyoepithelioma	9.9	KRT8 KRT7
38	skeletal muscle cancer	9.9	SSX2 SSX1 SS18
39	muscle cancer	9.9	SSX2 SSX1 SS18
40	intrahepatic gall duct cancer	9.9	KRT8 KRT7
41	squamous cell bile duct carcinoma	9.9	KRT8 KRT7
42	dedifferentiated liposarcoma	9.9	SSX2 SSX1 SS18
43	hidrocystoma	9.9	KRT8 KRT7
44	rhabdomyosarcoma 2	9.9	SSX2 SSX1 SS18
45	eccrine sweat gland neoplasm	9.9	KRT8 KRT7
46	myxoid liposarcoma	9.9	SSX2 SSX1 SS18
47	sarcomatous intrahepatic cholangiocarcinoma	9.9	KRT8 KRT7
48	eccrine papillary adenocarcinoma	9.9	KRT8 KRT7
49	cutaneous adenocystic carcinoma	9.9	KRT8 KRT7
50	mucinous tubular and spindle renal cell carcinoma	9.9	KRT8 KRT7

Graphical network of the top 20 diseases related to Synovium Neoplasm:

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Symptoms & Phenotypes for Synovium Neoplasm

GenomeRNAi Phenotypes related to Synovium Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-110	9.47	TLE1
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-111	9.47	TLE1
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-183	9.47	TLE1
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-23	9.47	SSX1
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-52	9.47	SSX1
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-76	9.47	SSX2
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-81	9.47	SSX2

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Drugs & Therapeutics for Synovium Neoplasm

Search Clinical Trials , NIH Clinical Center for Synovium Neoplasm

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Genetic Tests for Synovium Neoplasm

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Anatomical Context for Synovium Neoplasm

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Publications for Synovium Neoplasm

Articles related to Synovium Neoplasm:

#	Title	Authors	PMID	Year
1	Synovial hemangiomas of wrist and ankle joint: A report of two rare cases. ⁶¹	Saxena P...Tudu SK	30303163	2018
2	Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors. ⁶¹	Nilsson M...Mandahl N	12447678	2002
3	Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). ⁶¹	Layfield LJ...Harrelson JM	11079016	2000
4	[Primary study of histogenesis and diagnosis of synoviosarcoma]. ⁶¹	Yang GH...Zhao F	2560460	1989
5	Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. ⁶¹	Nielsen AL...Kiaer T	2545593	1989
6	[Tumors and tumor-like lesions of the hand]. ⁶¹	Geldmacher J...Flugel M	914105	1977

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Genes for Synovium Neoplasm

Genes related to Synovium Neoplasm (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SSX4B	SSX Family Member 4B	Protein Coding	5.74	DISEASES inferred ¹⁵
2	SSX4	SSX Family Member 4	Protein Coding	5.73	DISEASES inferred ¹⁵
3	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	5.32	DISEASES inferred ¹⁵
4	SS18	SS18 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	5.3	DISEASES inferred ¹⁵
5	SSX1	SSX Family Member 1	Protein Coding	5.26	DISEASES inferred ¹⁵
6	AKTIP	AKT Interacting Protein	Protein Coding	5.13	DISEASES inferred ¹⁵
7	SSX2	SSX Family Member 2	Protein Coding	4.91	DISEASES inferred ¹⁵
8	EHD1	EH Domain Containing 1	Protein Coding	4.72	DISEASES inferred ¹⁵
9	KRT8	Keratin 8	Protein Coding	4.4	DISEASES inferred ¹⁵
10	FLNA	Filamin A	Protein Coding	4.25	DISEASES inferred ¹⁵
11	KRT7	Keratin 7	Protein Coding	3.96	DISEASES inferred ¹⁵

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Variations for Synovium Neoplasm

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Expression for Synovium Neoplasm

Search GEO for disease gene expression data for Synovium Neoplasm.

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Pathways for Synovium Neoplasm

Pathways related to Synovium Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ⁴	11.62	KRT8 KRT7 FLNA
2	Transcriptional misregulation in cancer ³⁶	11.08	SSX2 SSX1 SS18

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GO Terms for Synovium Neoplasm

Cellular components related to Synovium Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	9.32	TLE1 SSX4B SSX4 SSX2 SSX1 SS18

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Sources for Synovium Neoplasm

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