Synovium Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Synovium Neoplasm

MalaCards integrated aliases for Synovium Neoplasm:

Name: Synovium Neoplasm ¹² ¹⁵

Synovial Neoplasm ¹²

Tumor of Synovium ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:315

NCIt ⁵⁰ C8964

SNOMED-CT ⁶⁷ 189829008

UMLS ⁷¹ C0476203

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Summaries for Synovium Neoplasm

MalaCards based summary : Synovium Neoplasm, also known as synovial neoplasm, is related to synovium cancer and nodular tenosynovitis. An important gene associated with Synovium Neoplasm is SSX4B (SSX Family Member 4B), and among its related pathways/superpathways is Transcriptional misregulation in cancer. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Synovium Neoplasm

Diseases related to Synovium Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)

#	Related Disease	Score	Top Affiliating Genes
1	synovium cancer	29.9	TLE1 SSX4B SSX4 SSX2 SSX1 SS18
2	nodular tenosynovitis	11.2
3	tendon sheath lipoma	11.1
4	tibial adamantinoma	10.1	TLE1 SSX1
5	adamantinoma of long bones	10.1	TLE1 SSX1
6	plica syndrome	10.1
7	pigmented villonodular synovitis	10.1
8	synovitis	10.1
9	malignant giant cell tumor	10.1
10	villonodular synovitis	10.1
11	congenital mesoblastic nephroma	10.1	SSX4B SSX2
12	cellular schwannoma	10.1	SSX1 SS18
13	malignant glandular tumor of peripheral nerve sheath	10.1	TLE1 SSX2
14	cellular congenital mesoblastic nephroma	10.0	TLE1 SSX2
15	kidney hemangiopericytoma	10.0	SSX2 SS18
16	meninges sarcoma	10.0	SSX2 SS18
17	bone angioendothelial sarcoma	10.0	SSX4B SSX4 SS18
18	spermatic cord cancer	10.0	SSX2 SSX1
19	heart sarcoma	10.0	SSX2 SSX1
20	extraosseous chondrosarcoma	10.0	SSX2 SS18
21	lung sarcoma	10.0	SSX2 SSX1
22	kidney fibrosarcoma	10.0	SSX2 SSX1
23	malignant fibrous histiocytoma	9.9
24	fibrous histiocytoma	9.9
25	proliferating trichilemmal cyst	9.9	KRT8 KRT7
26	endolymphatic sac tumor	9.9	KRT8 KRT7
27	subareolar duct papillomatosis	9.9	KRT8 KRT7
28	nipple benign neoplasm	9.9	KRT8 KRT7
29	benign breast adenomyoepithelioma	9.9	KRT8 KRT7
30	intrahepatic gall duct cancer	9.9	KRT8 KRT7
31	rhabdoid cancer	9.9	SSX2 SS18
32	squamous cell bile duct carcinoma	9.9	KRT8 KRT7
33	hidrocystoma	9.9	KRT8 KRT7
34	eccrine papillary adenocarcinoma	9.9	KRT8 KRT7
35	sarcomatous intrahepatic cholangiocarcinoma	9.9	KRT8 KRT7
36	cutaneous adenocystic carcinoma	9.9	KRT8 KRT7
37	mucinous tubular and spindle renal cell carcinoma	9.9	KRT8 KRT7
38	breast osteosarcoma	9.9	KRT8 KRT7
39	apocrine sweat gland neoplasm	9.9	KRT8 KRT7
40	adenoid squamous cell carcinoma	9.8	KRT8 KRT7
41	uterus leiomyosarcoma	9.8	KRT8 KRT7
42	uterine corpus sarcoma	9.8	KRT8 KRT7
43	intraductal breast benign neoplasm	9.8	KRT8 KRT7
44	breast benign neoplasm	9.8	KRT8 KRT7
45	cribriform carcinoma	9.8	KRT8 KRT7
46	eccrine papillary adenoma	9.8	KRT8 KRT7
47	sweat gland benign neoplasm	9.8	KRT8 KRT7
48	lymphoepithelioma-like carcinoma	9.8	KRT8 KRT7
49	pleomorphic carcinoma	9.8	KRT8 KRT7
50	epithelioid malignant peripheral nerve sheath tumor	9.8	TLE1 SSX2 SS18

Graphical network of the top 20 diseases related to Synovium Neoplasm:

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Symptoms & Phenotypes for Synovium Neoplasm

GenomeRNAi Phenotypes related to Synovium Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-110	9.55	TLE1
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-111	9.55	TLE1
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-183	9.55	TLE1
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-23	9.55	SSX1
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-52	9.55	SSX1
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-6	9.55	KRT8
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-71	9.55	KRT7 KRT8
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-76	9.55	SSX2
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-81	9.55	SSX2

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Drugs & Therapeutics for Synovium Neoplasm

Search Clinical Trials , NIH Clinical Center for Synovium Neoplasm

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Genetic Tests for Synovium Neoplasm

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Anatomical Context for Synovium Neoplasm

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Publications for Synovium Neoplasm

Articles related to Synovium Neoplasm:

#	Title	Authors	PMID	Year
1	Synovial hemangiomas of wrist and ankle joint: A report of two rare cases. ⁶¹	Saxena P...Tudu SK	30303163	2018
2	Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors. ⁶¹	Nilsson M...Mandahl N	12447678	2002
3	Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). ⁶¹	Layfield LJ...Harrelson JM	11079016	2000
4	[Primary study of histogenesis and diagnosis of synoviosarcoma]. ⁶¹	Yang GH...Zhao F	2560460	1989
5	Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. ⁶¹	Nielsen AL...Kiaer T	2545593	1989
6	[Tumors and tumor-like lesions of the hand]. ⁶¹	Geldmacher J...Flugel M	914105	1977

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Genes for Synovium Neoplasm

Genes related to Synovium Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SSX4B	SSX Family Member 4B	Protein Coding	5.8	DISEASES inferred ¹⁵
2	SSX4	SSX Family Member 4	Protein Coding	5.79	DISEASES inferred ¹⁵
3	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	5.38	DISEASES inferred ¹⁵
4	SS18	SS18 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	5.35	DISEASES inferred ¹⁵
5	SSX1	SSX Family Member 1	Protein Coding	5.34	DISEASES inferred ¹⁵
6	SSX2	SSX Family Member 2	Protein Coding	4.99	DISEASES inferred ¹⁵
7	KRT8	Keratin 8	Protein Coding	4.47	DISEASES inferred ¹⁵
8	KRT7	Keratin 7	Protein Coding	4.02	DISEASES inferred ¹⁵

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Variations for Synovium Neoplasm

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Expression for Synovium Neoplasm

Search GEO for disease gene expression data for Synovium Neoplasm.

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Pathways for Synovium Neoplasm

Pathways related to Synovium Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Transcriptional misregulation in cancer ³⁶	11.08	SSX2 SSX1 SS18

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GO Terms for Synovium Neoplasm

Cellular components related to Synovium Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	9.23	TLE1 SSX4B SSX4 SSX2 SSX1 SS18

Biological processes related to Synovium Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of transcription, DNA-templated	GO:0006355	9.02	TLE1 SSX4B SSX4 SSX2 SSX1

Molecular functions related to Synovium Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleic acid binding	GO:0003676	8.92	SSX4B SSX4 SSX2 SSX1

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Sources for Synovium Neoplasm

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