Synovium Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Synovium Neoplasm

MalaCards integrated aliases for Synovium Neoplasm:

Name: Synovium Neoplasm ¹² ¹⁵

Synovial Neoplasm ¹²

Tumor of Synovium ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:315

NCIt ⁴⁹ C8964

UMLS ⁷¹ C0476203

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Summaries for Synovium Neoplasm

MalaCards based summary : Synovium Neoplasm, also known as synovial neoplasm, is related to synovium cancer and tendon sheath lipoma. An important gene associated with Synovium Neoplasm is SSX4B (SSX Family Member 4B), and among its related pathways/superpathways are Cytoskeletal Signaling and Transcriptional misregulation in cancer. Affiliated tissues include bone, kidney and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Synovium Neoplasm

Diseases related to Synovium Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)

#	Related Disease	Score	Top Affiliating Genes
1	synovium cancer	30.3	TLE1 SSX4B SSX4 SSX2 SSX1 SS18
2	tendon sheath lipoma	11.3
3	nodular tenosynovitis	11.3
4	cellular neurofibroma	10.3	TLE1 SS18
5	tibial adamantinoma	10.3	TLE1 SSX1
6	adamantinoma of long bones	10.3	TLE1 SSX1
7	cellular schwannoma	10.3	SSX1 SS18
8	adult fibrosarcoma	10.3	TLE1 SSX1
9	malignant mesenchymoma	10.2	SSX4B SSX2
10	kidney hemangiopericytoma	10.2	SSX2 SS18
11	malignant glandular tumor of peripheral nerve sheath	10.2	TLE1 SSX2
12	meninges sarcoma	10.2	SSX2 SS18
13	epithelioid malignant peripheral nerve sheath tumor	10.2	SSX2 SS18
14	spermatic cord cancer	10.2	SSX2 SSX1
15	heart sarcoma	10.2	SSX2 SSX1
16	giant cell tumor	10.1
17	pigmented villonodular synovitis	10.1
18	synovitis	10.1
19	villonodular synovitis	10.1
20	rhabdoid cancer	10.1	SSX2 SS18
21	malignant giant cell tumor	10.1
22	mesenchymal cell neoplasm	10.0	SSX2 SS18
23	pleomorphic liposarcoma	10.0	SS18 KRT8
24	well-differentiated liposarcoma	10.0	SS18 KRT7
25	lung sarcoma	10.0	SSX2 SSX1 SS18
26	kidney sarcoma	10.0	SSX2 SSX1 SS18
27	cellular myxoid liposarcoma	10.0	SSX2 SSX1 SS18
28	myxoid liposarcoma	10.0	SSX2 SSX1 SS18
29	proliferating trichilemmal cyst	10.0	KRT8 KRT7
30	extraosseous chondrosarcoma	10.0	SSX2 SSX1 SS18
31	endolymphatic sac tumor	10.0	KRT8 KRT7
32	bladder clear cell adenocarcinoma	10.0	KRT7 EHD1
33	chondrosarcoma, extraskeletal myxoid	10.0	SSX2 SSX1 SS18
34	skeletal muscle cancer	10.0	SSX2 SSX1 SS18
35	subareolar duct papillomatosis	10.0	KRT8 KRT7
36	muscle cancer	10.0	SSX2 SSX1 SS18
37	nipple neoplasm	10.0	KRT8 KRT7
38	rhabdomyosarcoma 2	9.9	SSX2 SSX1 SS18
39	intrahepatic gall duct cancer	9.9	KRT8 KRT7
40	hidrocystoma	9.9	KRT8 KRT7
41	mucinous tubular and spindle renal cell carcinoma	9.9	KRT8 KRT7
42	adenoid squamous cell carcinoma	9.9	KRT8 KRT7
43	malignant fibroxanthoma	9.9
44	histiocytoma	9.9
45	fibrous histiocytoma	9.9
46	undifferentiated pleomorphic sarcoma	9.9
47	cutaneous adenocystic carcinoma	9.9	KRT8 KRT7
48	apocrine sweat gland neoplasm	9.9	KRT8 KRT7
49	sweat gland neoplasm	9.9	KRT8 KRT7
50	keratinizing squamous cell carcinoma	9.9	KRT8 KRT7

Graphical network of the top 20 diseases related to Synovium Neoplasm:

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Symptoms & Phenotypes for Synovium Neoplasm

GenomeRNAi Phenotypes related to Synovium Neoplasm according to GeneCards Suite gene sharing:

²⁶ (show all 22)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	10.15	SSX2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-110	10.15	TLE1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	10.15	SSX1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	10.15	TLE1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-146	10.15	TLE1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-147	10.15	TLE1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	10.15	SSX1 SSX2 SSX4 SSX4B
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-183	10.15	TLE1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-191	10.15	SSX2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	10.15	SSX4 SSX4B
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-23	10.15	SSX1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	10.15	SSX2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	10.15	SSX4 SSX4B
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-51	10.15	SSX4 SSX4B
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	10.15	SSX1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	10.15	TLE1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	10.15	SSX1 TLE1
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-67	10.15	SSX4 SSX4B
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-76	10.15	SSX2
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-77	10.15	SSX1 SSX2 TLE1
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	10.15	SSX2
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-82	10.15	TLE1 SSX4 SSX4B

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Drugs & Therapeutics for Synovium Neoplasm

Search Clinical Trials , NIH Clinical Center for Synovium Neoplasm

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Genetic Tests for Synovium Neoplasm

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Anatomical Context for Synovium Neoplasm

MalaCards organs/tissues related to Synovium Neoplasm:

⁴⁰

Bone, Kidney, Breast, Heart, Skeletal Muscle, Lung, Uterus

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Publications for Synovium Neoplasm

Articles related to Synovium Neoplasm:

#	Title	Authors	PMID	Year
1	Synovial hemangiomas of wrist and ankle joint: A report of two rare cases. ⁶¹	Saxena P...Tudu SK	30303163	2018
2	Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors. ⁶¹	Nilsson M...Mandahl N	12447678	2002
3	Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). ⁶¹	Layfield LJ...Harrelson JM	11079016	2000
4	[Primary study of histogenesis and diagnosis of synoviosarcoma]. ⁶¹	Yang GH...Zhao F	2560460	1989
5	Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. ⁶¹	Nielsen AL...Kiaer T	2545593	1989
6	[Tumors and tumor-like lesions of the hand]. ⁶¹	Geldmacher J...Flugel M	914105	1977

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Genes for Synovium Neoplasm

Genes related to Synovium Neoplasm (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SSX4B	SSX Family Member 4B	Protein Coding	5.72	DISEASES inferred ¹⁵
2	SSX4	SSX Family Member 4	Protein Coding	5.72	DISEASES inferred ¹⁵
3	SS18	SS18 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	5.34	DISEASES inferred ¹⁵
4	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	5.34	DISEASES inferred ¹⁵
5	SSX1	SSX Family Member 1	Protein Coding	5.24	DISEASES inferred ¹⁵
6	AKTIP	AKT Interacting Protein	Protein Coding	5.16	DISEASES inferred ¹⁵
7	SSX2	SSX Family Member 2	Protein Coding	4.9	DISEASES inferred ¹⁵
8	EHD1	EH Domain Containing 1	Protein Coding	4.73	DISEASES inferred ¹⁵
9	KRT8	Keratin 8	Protein Coding	4.38	DISEASES inferred ¹⁵
10	FLNA	Filamin A	Protein Coding	4.24	DISEASES inferred ¹⁵
11	KRT7	Keratin 7	Protein Coding	3.93	DISEASES inferred ¹⁵

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Variations for Synovium Neoplasm

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Expression for Synovium Neoplasm

Search GEO for disease gene expression data for Synovium Neoplasm.

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Pathways for Synovium Neoplasm

Pathways related to Synovium Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ⁴	11.62	KRT8 KRT7 FLNA
2	Transcriptional misregulation in cancer ³⁶	11.07	SSX2 SSX1 SS18

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GO Terms for Synovium Neoplasm

Cellular components related to Synovium Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	9.32	TLE1 SSX4B SSX4 SSX2 SSX1 SS18
2	intracellular	GO:0005622	9.26	SSX4B SSX4 SSX2 SSX1

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Sources for Synovium Neoplasm

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