MCID: SYP003
MIFTS: 60

Syphilis

Categories: Bone diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases
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Aliases & Classifications for Syphilis

Summaries for Syphilis

MedlinePlus: 41 Syphilis is a sexually transmitted disease caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy. The early stage of syphilis usually causes a single, small, painless sore. Sometimes it causes swelling in nearby lymph nodes. If you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. Many people do not notice symptoms for years. Symptoms can go away and come back. The sores caused by syphilis make it easier to get or give someone HIV during sex. If you are pregnant, syphilis can cause complications, or you could lose your baby. In rare cases, syphilis causes serious health problems and even death. Syphilis is easy to cure with antibiotics if you catch it early. Correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. If your or your partner is allergic to latex, you can use polyurethane condoms. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex. Centers for Disease Control and Prevention

MalaCards based summary: Syphilis, also known as chancre, is related to congenital syphilis and tertiary syphilis, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Disease and Innate Immune System. The drugs Tetracycline and Benzylpenicillin have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and whole blood, and related phenotypes are homeostasis/metabolism and nervous system

Disease Ontology: 11 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC: 2 Syphilis is a sexually transmitted infection that can cause serious health problems if it is not treated. Syphilis is divided into stages (primary, secondary, latent, and tertiary). There are different signs and symptoms associated with each stage.

Wikipedia: 75 Syphilis (/ˈsɪfɪlɪs/) is a sexually transmitted infection caused by the bacterium Treponema pallidum... more...

Related Diseases for Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1278)
# Related Disease Score Top Affiliating Genes
1 congenital syphilis 33.1 CRP CD79A CD40LG CD4
2 tertiary syphilis 32.7 TNF MIR570 CRP CD4
3 secondary syphilis 32.6 TNF CRP CD4 CCR5
4 syphilitic meningitis 32.6 CRP CD4
5 late congenital syphilis 32.3 FOXP3 CRP
6 tertiary neurosyphilis 32.2 MIR570 CD4
7 uveitis 31.4 TNF IL17A HLA-DRB1 CCR5
8 exanthem 31.4 TNF IL17A CRP CD4
9 hepatitis b 31.3 TNF TLR2 HLA-DRB1 BCL2
10 posterior uveitis 31.1 TNF IL17A CD4
11 human immunodeficiency virus type 1 31.1 HLA-C CD4 CD209 CCR5 B2M
12 chlamydia 31.1 TNF TLR2 IL17A CRP CD79A CCR5
13 keratitis, hereditary 31.0 TNF TLR2 IL17A CD4
14 chorioretinitis 31.0 TNF IL17A CRP CD4
15 toxoplasmosis 30.9 TNF IL17A CD79A CD40LG CCR5
16 rubella 30.9 TNF HLA-DRB1 HLA-C CD40LG
17 choroiditis 30.9 TNF IL17A CRP CD4
18 optic papillitis 30.9 TNF CRP CD4
19 optic neuritis 30.9 TNF HLA-DRB1 CCR5
20 panuveitis 30.9 TNF IL17A HLA-DRB1 CRP CD4
21 anterior uveitis 30.8 TNF TLR2 IL17A HLA-DRB1 CRP CD4
22 lichen planus 30.8 TNF IL17A FOXP3
23 lyme disease 30.8 TNF TLR2 IL17A HLA-DRB1 CRP CD40LG
24 retinal vasculitis 30.8 TNF CD4 APOH
25 viral hepatitis 30.7 TLR2 HLA-DRB1 FAS CRP
26 human immunodeficiency virus infectious disease 30.7 TNF FAS CD79A CD4 CD209 CCR5
27 osteomyelitis 30.7 TNF TLR2 CRP
28 nephrotic syndrome 30.7 TNF IL17A FN1 CRP CD79A CD4
29 genital herpes 30.7 TNF TLR2 CD4 CCR5
30 myelitis 30.7 TNF IL17A APOH
31 leprosy 3 30.7 TNF TLR2 IL17A HLA-DRB1 HLA-C FOXP3
32 vasculitis 30.7 TNF IL17A HLA-DRB1 CRP CD79A CD40LG
33 leptospirosis 30.6 TNF TLR2 CRP
34 lymphadenitis 30.6 TNF FAS CRP CD209
35 alopecia areata 30.6 TNF IL17A HLA-DRB1 HLA-C FOXP3
36 granuloma annulare 30.6 TNF IL17A CD4
37 meningitis 30.6 TNF TLR2 IL17A FN1 CRP
38 vascular disease 30.6 TNF FN1 CRP CD40LG APOH
39 typhoid fever 30.6 TNF HLA-DRB1 CRP
40 dermatophytosis 30.6 TNF IL17A CD4
41 aortitis 30.6 TNF IL17A HLA-DRB1 CRP CD4
42 trichomoniasis 30.6 TNF CD4 CCR5
43 hepatitis a 30.6 TNF HLA-DRB1 CD4 CCR5
44 orchitis 30.6 TNF IL17A FOXP3 CRP CD4
45 pulmonary tuberculosis 30.5 TNF TLR2 HLA-DRB1 CRP CP
46 acquired immunodeficiency syndrome 30.5 TNF CRP CD79A CD40LG CD4 CCR5
47 iritis 30.5 TNF IL17A CRP CD4
48 bone inflammation disease 30.5 TNF TLR2 IL17A HLA-DRB1 FOXP3 CRP
49 alcohol use disorder 30.5 TNF CRP CD4
50 anogenital venereal wart 30.5 TNF TLR2 CD4

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to Syphilis

Symptoms & Phenotypes for Syphilis

UMLS symptoms related to Syphilis:


fever; pruritus; pelvic pain; syphilitic chancre; gummatous inflammation

MGI Mouse Phenotypes related to Syphilis:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 APOH B2M BCL2 CCR5 CD209 CD4
2 nervous system MP:0003631 10.29 B2M BCL2 CCR5 CD4 CD40LG CD79A
3 cellular MP:0005384 10.21 B2M BCL2 CCR5 CD209 CD4 CD40LG
4 liver/biliary system MP:0005370 10.18 B2M CCR5 CD79A CP FAS FN1
5 immune system MP:0005387 10.16 B2M BCL2 CCR5 CD209 CD4 CD40LG
6 digestive/alimentary MP:0005381 10.14 B2M BCL2 CCR5 CD209 CD4 FAS
7 neoplasm MP:0002006 10.13 B2M BCL2 CCR5 CD79A FAS FN1
8 endocrine/exocrine gland MP:0005379 10.13 B2M BCL2 CD4 CD40LG FAS FOXP3
9 renal/urinary system MP:0005367 10.1 BCL2 CD209 CD40LG CD79A FAS FOXP3
10 cardiovascular system MP:0005385 10.1 B2M BCL2 CCR5 CD40LG CP CRP
11 hematopoietic system MP:0005397 10.06 B2M BCL2 CCR5 CD209 CD4 CD40LG
12 mortality/aging MP:0010768 9.86 APOH B2M BCL2 CCR5 CD209 CD4
13 integument MP:0010771 9.36 B2M BCL2 CD4 CD40LG FAS FN1

Drugs & Therapeutics for Syphilis

Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tetracycline Approved, Vet_approved, Withdrawn Phase 4 60-54-8 5353990
2
Benzylpenicillin Approved, Vet_approved Phase 4 61-33-6 5904
3
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5 Antiviral Agents Phase 4
6 Anti-HIV Agents Phase 4
7 Reverse Transcriptase Inhibitors Phase 4
8 Penicillins Phase 4
9 Penicillin G Procaine Phase 4
10 Penicillin G Benzathine Phase 4
11 Anti-Bacterial Agents Phase 4
12 Anti-Infective Agents Phase 4
13 Antiprotozoal Agents Phase 4
14 Antiparasitic Agents Phase 4
15 Antimalarials Phase 4
16
Diamorphine Approved, Illicit, Investigational Phase 3 561-27-3 5462328
17
Azithromycin Approved Phase 3 83905-01-5 447043
18
Cefixime Approved, Investigational Phase 3 79350-37-1 5362065
19 Antibiotics, Antitubercular Phase 3
20
Amoxicillin Approved, Vet_approved Phase 1 26787-78-0 33613
21
Probenecid Approved, Investigational Phase 1 57-66-9 4911
22 Antirheumatic Agents Phase 1
23
Ethanol Approved 64-17-5 702
24
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
25
Tannic acid Approved 1401-55-4 16129878 16129778
26
Sulfamethazine Approved, Investigational, Vet_approved 57-68-1 5327
27
Racivir Approved, Investigational 143491-57-0, 143491-54-7 60877
28
Methadone Approved 76-99-3, 1095-90-5 4095
29
Linezolid Approved, Investigational Early Phase 1 165800-03-3 441401
30
Sodium fluoride Approved 7681-49-4
31
Tenofovir Experimental, Investigational 147127-20-6, 202138-50-9 464205 6398764
32 Vaccines
33 Immunologic Factors
34 Hepatitis C Antibodies
35 Analgesics
36 Anti-Inflammatory Agents, Non-Steroidal
37 Analgesics, Non-Narcotic
38 Anti-Inflammatory Agents
39 Chrysarobin
40 Anti-Retroviral Agents
41 Analgesics, Opioid
42 Listerine

Interventional clinical trials:

(show top 50) (show all 77)
# Name Status NCT ID Phase Drugs
1 Use of Tenofovir/Emtricitabine With Immediate or Deferred Doxycycline 100mg PO Daily for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative Men Who Have Sex With Men: a Pilot Study of Dual Daily HIV and Syphilis PrEP. (The DuDHS Trial). Unknown status NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
2 A Randomized, Placebo-controlled Trial of Oral Doxycycline for the Prevention of Syphilis in HIV-positive Men Who Have Sex With Men (MSM) Unknown status NCT02864550 Phase 4 Doxycycline
3 Randomized, Clinical Trial to Compare the Serological Response Rates of Serofast Early Syphilis Cases Retreated With Three Doses Benzathine Penicillin and Absence of Any Retreatment Unknown status NCT02884115 Phase 4 benzathine penicillin
4 Doctor of Medicine Unknown status NCT02857959 Phase 4 Benzathine Penicillin G
5 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Unknown status NCT02871505 Phase 4 Benzathine Penicillin G
6 Syphilis Self-testing to Expand Test Uptake Among Men Who Have Sex With Men (SST) Completed NCT04480749 Phase 4
7 Syphilis Response to Higher Penicillin Dosage in HIV Co-Infected Patients Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
8 A Phase 4 Comparative Trial of Benzathine Penicillin G 2.4 Million Units Administered as a Single Dose Versus Three Successive Weekly Doses for Treatment of Early Syphilis in Subjects With or Without HIV Infection Recruiting NCT03637660 Phase 4 Benzathine Penicillin
9 PrEP and dPEP: Doxycycline Post-exposure Prophylaxis for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV Pre-exposure Prophylaxis Active, not recruiting NCT04050540 Phase 4 Doxycycline
10 Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men Active, not recruiting NCT03980223 Phase 4 Doxycycline Hyclate Delayed-Release 200 mg
11 A COMMUNITY-BASED, RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE EFFICACY OF COMPREHENSIVE HIV/STIs INTERVENTION AMONG MEN WHO HAVE SEX WITH MEN IN 8 CITIES IN CHINA Unknown status NCT01068015 Phase 3
12 A Randomized Community Intervention Trial on Reducing HIV Infection Among Drug Users Attending Methadone Maintenance Treatment(MMT) and Preventing Secondary Transmission From HIV Positive Clients to Their Sexual Partners in China Unknown status NCT01108614 Phase 3
13 Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
14 A Phase III Equivalence Trial of Azithromycin vs. Benzathine Penicillin for the Treatment of Early Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
15 Randomized Trial of Male Circumcision for HIV Prevention, Rakai, Uganda Completed NCT00425984 Phase 3
16 Oral and Neuro-Penetrative Alternative Antibiotics for Patients With Syphilis Recruiting NCT05069974 Phase 3 Linezolid;Benzathine Penicilllin G
17 A Randomized Non-Inferiority Clinical Trial of Doxycyline Vs BPG for Early Syphilis Recruiting NCT04838717 Phase 3 BPG;Doxycycline
18 Clinical Trial Comparing the Effectiveness of Cefixime Versus Penicillin G for Treatment of Early Syphilis Recruiting NCT04958122 Phase 3 Cefixime 400mg;benzathine penicillin
19 Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women Unknown status NCT03752112 Phase 1, Phase 2 Cefixime;Benzathine penicillin 2.4 million units
20 Clinical Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis Completed NCT03660488 Phase 2 Cefixime 400 milligram Oral Capsule [Suprax];Benzathine Penicillin G
21 A Randomized, Placebo-controlled, Double-blind Trial to Assess Expanded Safety, Acceptability and Preliminary Effectiveness of PC-515 (Lambda Carrageenan) for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2 Carraguard (PC-515)
22 HoMBReS: A Lay Health Advisor Approach to Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
23 A Trial to Assess Expanded Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing STI/HIV Transmission Completed NCT00213018 Phase 2 Carraguard (PC-515)
24 A Brief, Clinic-Based, Safer Sex Program for Young African-American Men Completed NCT01439503 Phase 2
25 A Randomized, Placebo-controlled, Double-blind Trial to Assess Expanded Safety and Acceptability of Carraguard™ (PC-515) Vaginal Gel Among Heterosexual Couples in Chiang Rai Completed NCT00213057 Phase 1 Carraguard (PC-515)
26 A Rational Approach to the Identification of New Treatment Options to Prevent Congenital Syphilis: Phase 1 Study of the Pharmacokinetics of High Dose Amoxicillin With and Without Probenecid in Pregnant Women Not yet recruiting NCT05309928 Phase 1 Amoxicillin
27 Descriptive Cohort of Acquired Syphlis by Non Sexual Contact Unknown status NCT04455425
28 Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases in Context of ETMIplus Program, OPS/OMS. Multicentric Study Unknown status NCT04084379
29 Finding the Latent Treponema Pallidum of Syphilis With Serofast Status Unknown status NCT03754517
30 Comparison of Different Partner Notification Strategies After Antenatal Syphilis Screening Unknown status NCT02262390
31 A Methadone Maintenance Treatment Outcome Study in Three Provinces in China: Comparative Evaluation of the Impact of an Intensive Health Care Provider Training Program Combined With Expanded Services on Treatment Retention, Heroin Use, Methadone Dosing and HIV Risk Practices Unknown status NCT01315054
32 Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men (MSM) Unknown status NCT01300689
33 Multi-site Study of Rapid Diagnostic Syphilis Assays of Persons Attending STD Clinics in High Syphilis Morbidity Areas Completed NCT00300534
34 Comparisons of Treatment Response to Standard Treatment With Penicillin Between HIV-infected and HIV-uninfected Patients With Syphilis Completed NCT01944358
35 Congenital Syphilis at Third-level Pediatric Hospital. A Prospective Cohort With Retrospective Evaluation Study of the Last Three Decades. Completed NCT04137601
36 Preventing Congenital Syphilis Completed NCT02353117
37 Whole Genome Sequencing of Syphilis Using Routine Clinical Samples Completed NCT03709862
38 Enhanced Syphilis Screening Among HIV-positive Men (ESSAHM): Evaluation of a Clinic-based Intervention Completed NCT02019043
39 Video Tool to Promote Syphilis Knowledge and Testing in the Emergency Department Completed NCT00552539
40 A Randomized Study to Compare Three Counseling Strategies and Evaluate the Efficacy of Reminders for Regular HIV, Hepatitis B and C, and Syphilis Testing Completed NCT02752152
41 Video Tool to Promote Knowledge of Syphilis as Facilitator of HIV Transmission Completed NCT00553111
42 Doxycycline Prophylaxis or Incentive Payments to Reduce Incident Syphilis Among HIV- Infected Men Who Have Sex With Men Who Continue to Engage in High Risk Sex: A Randomized, Controlled Pilot Study Completed NCT02257658 Doxycycyline
43 Treponema Pallidum-specific Proteomic Changes in Patients With Incident Syphilis Infection: an Observational Study in Belgium Completed NCT02059525
44 Lumbar Puncture and Syphilis Outcome Completed NCT02031146
45 Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in COLOMBIA Completed NCT02454816
46 Utilization of the Community Popular Opinion Leader (C-POL) Model to Achieve Syphilis Elimination in Alabama Completed NCT00260754
47 A Community-Based Intervention With Popular Opinion Leaders (C-POL) in Texas to Achieve Syphilis Elimination Completed NCT00260715
48 Field Performance Evaluation of Dual Rapid HIV & Syphilis Tests in Zambia Completed NCT02445846
49 Feasibility of Introducing an Onsite Test for Syphilis in the Package of Antenatal Care at the Rural Primary Health Care Level in Burkina Faso Completed NCT03156751
50 Evaluation of the MBio Combined Syphilis/HIV Point-of-Care Diagnostic Test Completed NCT01530672

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ERYTHROMYCIN PWDR

Cochrane evidence based reviews: chancre

Genetic Tests for Syphilis

Genetic tests related to Syphilis:

# Genetic test Affiliating Genes
1 Syphilis 28

Anatomical Context for Syphilis

Organs/tissues related to Syphilis:

MalaCards : Skin, Heart, Whole Blood, Brain, Liver, Bone, Eye

Publications for Syphilis

Articles related to Syphilis:

(show top 50) (show all 27739)
# Title Authors PMID Year
1
HIV and syphilis knowledge, perceptions, and practices among Myanmar migrant workers in Samut Sakhon Province, Thailand. 62 41
36443736 2022
2
Determinants of gestational syphilis among women attending prenatal care programs in the Brazilian Amazon. 62 41
36438302 2022
3
Syphilis in pregnancy and congenital syphilis: women's experiences from the perspective of symbolic interactionism. 62 41
36449977 2022
4
Antiphospholipid antibodies, antiphospholipid syndrome and infections. 53 62
18295729 2008
5
[Antiphospholipid syndrome: pathophysiology and clinicobiological aspects]. 53 62
19469420 2008
6
Intrathecal antitreponemal antibody synthesis determination using the INNO-LIA Syphilis Score. 53 62
18204743 2007
7
Effect of genital ulcer disease on HIV-1 coreceptor expression in the female genital tract. 53 62
18008231 2007
8
Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis. 53 62
17299719 2007
9
Hysteroscopy in the evaluation of patients with recurrent pregnancy loss: a cohort study in a primary care population. 53 62
15809790 2004
10
Factor V Leiden mutation in Sneddon syndrome. 53 62
12765305 2003
11
Anti-beta2-glycoprotein I antibodies in pediatric systemic lupus erythematosus and antiphospholipid syndrome. 53 62
12209489 2002
12
Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. 53 62
11491498 2001
13
Antiphospholipid antibody syndrome. A literature review. 53 62
11367816 2001
14
Different types of antiphospholipid antibodies in AIDS: a comparison with syphilis and the antiphospholipid syndrome. 53 62
10554081 1999
15
[The antiphospholipid syndrome--yesterday, today, tomorrow]. 53 62
9623352 1998
16
Antiphospholipid antibodies: guidelines for determination. 53 62
19078229 1997
17
Update: antiphospholipid antibodies. 53 62
19078201 1997
18
[The incidence of the antiphospholipid syndrome in the clinical and biological manifestations of systemic lupus erythematosus]. 53 62
9424663 1997
19
Antibodies to beta2-glycoprotein I--a specific marker for the antiphospholipid syndrome. 53 62
9276526 1997
20
Lupus anticoagulants: diagnostic dilemma and clinical challenge. 53 62
10169622 1997
21
Prevalence and clinical significance of IgG isotype anti-beta 2-glycoprotein I antibodies in antiphospholipid syndrome: a comparative study with anticardiolipin antibodies. 53 62
9142046 1997
22
Autoantibodies to phospholipids and to the coagulation proteins in AIDS. 53 62
9184392 1997
23
Antiphospholipid antibodies and atherosclerosis. 53 62
8902778 1996
24
Reactivity to beta 2 glycoprotein I clearly differentiates anticardiolipin antibodies from antiphospholipid syndrome and syphilis. 53 62
8725711 1996
25
Anticardiolipin antibodies from syphilis and systemic lupus erythematosus induce leakage in cardiolipin vesicles. 53 62
8736113 1996
26
Prevalence of antiphospholipid antibodies in patients with ankylosing spondylitis. 53 62
8991987 1995
27
Antibodies to phospholipid-free beta 2-glycoprotein-I in patients with primary antiphospholipid syndrome. 53 62
8991988 1995
28
Comparison of the effects of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation. 53 62
7667838 1995
29
[A case of systemic lupus erythematosus associated with severe fibrinoid necrosis located mainly in the glomerular afferent arteriole]. 53 62
7699957 1995
30
Presence of multiple anti-phospholipid antibody specificities in a pediatric population. 53 62
8679908 1995
31
[Middle cerebral artery occlusion with unilateral moyamoya like vessels and with ruptured anterior cerebral artery aneurysm--its relation to the antiphospholipid antibody syndrome]. 53 62
7826715 1994
32
Association of antimitochondrial antibodies type 5 and anti-beta 2 glycoprotein I antibodies in the antiphospholipid syndrome. 53 62
7799349 1994
33
Differences in functional activity of anticardiolipin antibodies from patients with syphilis and those with antiphospholipid syndrome. 53 62
8063429 1994
34
Clinical and therapeutic aspects associated to phospholipid binding antibodies (lupus anticoagulant and anticardiolipin antibodies). 53 62
7988946 1994
35
[Primary antiphospholipid syndrome: clinical and biological study of 36 cases]. 53 62
8189783 1994
36
Postpartum myocardial infarction in a patient with antiphospholipid syndrome. 53 62
8155200 1994
37
Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. 53 62
7918046 1993
38
High prevalence of anti-cardiolipin antibody, C1q-, C3d-, and mRF-IgG immune complexes, and anti-nuclear antibody in hemophiliacs irrespective of infection with human immunodeficiency virus type 1. 53 62
8410668 1993
39
Lupoid sclerosis with antiphospholipid and antimyelin antibodies. 53 62
8496878 1993
40
Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2-glycoprotein I. 53 62
1522218 1992
41
Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. 53 62
1602135 1992
42
Antiphospholipid antibody syndrome: a case report and review of the literature. 53 62
1801188 1991
43
[Anticardiolipin antibodies in diffuse connective tissue diseases with IgG, IgM and IgA isotypes]. 53 62
2267732 1990
44
Vasculopathy associated with the antiphospholipid antibody syndrome. 53 62
2189163 1990
45
Biological true and false serological tests for syphilis: their relationship with anticardiolipin antibodies. 53 62
2340925 1990
46
Microfluidic electrochemical device for real-time culturing and interference-free detection of Escherichia coli. 62
36442949 2023
47
Effects of marriage equality legislation on sexual health of the US population. 62
36165350 2023
48
High prevalence of vitamin D deficiency in HIV-infected individuals in comparison with the general population across Punjab province, Pakistan. 62
36387030 2023
49
Primary syphilis presenting as a painful unilateral inguinal lymphadenopathy, without cutaneous manifestations, in a 71-year-old Japanese man: A case report. 62
36388614 2023
50
A monkeypox virus infection mimicking primary syphilis. 62
36005947 2022

Variations for Syphilis

Copy number variations for Syphilis from CNVD:

6
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 111152 17 35097918 35138441 Copy number ERBB2 Syphilis

Expression for Syphilis

Search GEO for disease gene expression data for Syphilis.

Pathways for Syphilis

Pathways related to Syphilis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 TLR2 IL17A HLA-C FN1 CP CD79A
2
Show member pathways
13.72 TNF TLR2 IL17A HLA-DRB1 HLA-C FN1
3
Show member pathways
13.44 TLR2 HLA-DRB1 HLA-C CD79A CD40LG CD4
4
Show member pathways
13.3 TNF TLR2 IL17A FAS CD40LG CD4
5
Show member pathways
13.2 BCL2 CCR5 CD4 CD40LG FAS IL17A
6
Show member pathways
13.04 B2M BCL2 CCR5 CD4 CD40LG FN1
7
Show member pathways
12.83 TNF FN1 FAS CD4 CCR5 BCL2
8
Show member pathways
12.78 BCL2 CD209 FAS TLR2 TNF
9
Show member pathways
12.57 TNF FAS CD40LG CD4 CCR5
10
Show member pathways
12.52 TNF TLR2 FAS CD40LG BCL2
11
Show member pathways
12.5 TNF IL17A FN1 CD4 BCL2
12
Show member pathways
12.35 TNF TLR2 FN1 FAS
13
Show member pathways
12.28 TNF FAS CD40LG BCL2
14 12.07 TNF TLR2 IL17A FOXP3 FAS CD79A
15
Show member pathways
11.98 TNF IL17A HLA-DRB1 CD40LG CD4
16 11.89 TNF CD79A CD4 CD209
17 11.83 BCL2 FN1 IL17A TNF
18
Show member pathways
11.8 TLR2 IL17A CD4
19
Show member pathways
11.78 TNF TLR2 IL17A CD4
20 11.73 TNF IL17A CD4
21
Show member pathways
11.7 HLA-DRB1 CRP CD4
22 11.68 TNF CD4 CD209
23
Show member pathways
11.67 TNF CD40LG BCL2
24 11.64 CD4 FOXP3 IL17A
25 11.63 CD40LG CD4 CCR5 BCL2
26
Show member pathways
11.62 TNF FOXP3 CD40LG
27 11.59 TNF CRP CD79A CD40LG
28
Show member pathways
11.56 TNF TLR2 FOXP3
29 11.44 TNF HLA-DRB1 CD40LG CD4
30 11.31 FAS HLA-C HLA-DRB1
31
Show member pathways
11.23 BCL2 FAS FOXP3 TNF
32 11.15 TNF HLA-DRB1 CD4
33 11.14 TNF IL17A HLA-DRB1 HLA-C FOXP3 FAS
34 10.96 TNF IL17A FN1 CD40LG BCL2
35 10.74 TNF FN1 CRP BCL2

GO Terms for Syphilis

Cellular components related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005887 10.28 CCR5 CD4 CD40LG HLA-C HLA-DRB1 TLR2
2 plasma membrane GO:0005886 10.28 CCR5 CD4 CD40LG HLA-C HLA-DRB1 TLR2
3 cell surface GO:0009986 9.96 APOH B2M CCR5 CD209 CD4 CD40LG
4 membrane raft GO:0045121 9.85 TNF TLR2 FAS CD79A CD4
5 external side of plasma membrane GO:0009897 9.62 TNF IL17A HLA-DRB1 FAS CD79A CD40LG

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 10.22 CD209 CD4 CD79A HLA-C HLA-DRB1 IL17A
2 inflammatory response GO:0006954 10.1 TNF TLR2 IL17A FOXP3 CRP CD40LG
3 defense response to Gram-positive bacterium GO:0050830 10.06 TNF TLR2 IL17A CRP
4 B cell proliferation GO:0042100 10 CD79A CD40LG BCL2
5 positive regulation of interleukin-12 production GO:0032735 9.99 TLR2 IL17A CD40LG
6 positive regulation of T cell activation GO:0050870 9.88 HLA-DRB1 CD4 B2M
7 response to radiation GO:0009314 9.85 BCL2 FOXP3 TNF
8 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0032831 9.8 HLA-DRB1 FOXP3
9 antigen processing and presentation GO:0019882 9.73 HLA-DRB1 HLA-C CD209
10 signaling GO:0023052 9.62 TNF CD40LG CCR5
11 immune system process GO:0002376 9.56 TLR2 IL17A HLA-DRB1 HLA-C CD79A CD4
12 regulation of immunoglobulin production GO:0002637 9.55 CD40LG FOXP3 TNF
13 immune response GO:0006955 9.55 TNF TLR2 IL17A HLA-DRB1 HLA-C FAS

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.68 TNF TLR2 FOXP3 FN1 FAS CRP
2 peptide antigen binding GO:0042605 9.63 HLA-DRB1 HLA-C CD209
3 MHC class II protein complex binding GO:0023026 9.43 HLA-DRB1 CD4 B2M

Sources for Syphilis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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