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MIFTS: 59

Syphilis

Categories: Bone diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Syphilis

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MalaCards integrated aliases for Syphilis:

Name: Syphilis 12 73 29 54 42 3 15 17 70
Chancre 44 17
Syphilitic Chancre 12

Classifications:

MalaCards categories:
Global: Infectious diseases Fetal diseases Rare diseases
Anatomical: Skin diseases Immune diseases Reproductive diseases Neuronal diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:4166
MeSH 44 D002601
SNOMED-CT 67 736686006
ICD10 32 A51.0 A53.9
UMLS 70 C0007939 C0039128
Sources

Summaries for Syphilis

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MedlinePlus : 42 Syphilis is a sexually transmitted disease caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy. The early stage of syphilis usually causes a single, small, painless sore. Sometimes it causes swelling in nearby lymph nodes. If you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. Many people do not notice symptoms for years. Symptoms can go away and come back. The sores caused by syphilis make it easier to get or give someone HIV during sex. If you are pregnant, syphilis can cause complications, or you could lose your baby. In rare cases, syphilis causes serious health problems and even death. Syphilis is easy to cure with antibiotics if you catch it early. Correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. If your or your partner is allergic to latex, you can use polyurethane condoms. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex. Centers for Disease Control and Prevention

MalaCards based summary : Syphilis, also known as chancre, is related to congenital syphilis and latent syphilis, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Procaine and Penicillin G have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and tongue, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC : 3 Syphilis is a sexually transmitted infection that can cause serious health problems if it is not treated. Syphilis is divided into stages (primary, secondary, latent, and tertiary). There are different signs and symptoms associated with each stage.

Wikipedia : 73 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

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Related Diseases for Syphilis

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Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1176)
# Related Disease Score Top Affiliating Genes
1 congenital syphilis 33.2 TPR CD79A CD40LG CD4
2 latent syphilis 32.7 TPR CD8A CD4
3 late congenital syphilis 32.7 FOXP3 CRP
4 asymptomatic neurosyphilis 32.6 IL17A CD4
5 early congenital syphilis 32.6 TPR FOXP3 CRP
6 primary syphilis 32.6 TPR CRP CD8A CD4
7 tertiary syphilis 32.6 TPR CRP CD8A CD4
8 gummatous syphilis 32.5 TPR CRP
9 tertiary neurosyphilis 32.3 TPR CD4
10 secondary syphilis 32.0 TPR FN1 CRP CD8A CD79A CD40LG
11 syphilitic meningitis 31.7 CRP CD8A CD4 APOH
12 mikulicz disease 31.7 CRP CD4 CCR6
13 chlamydia 31.5 IL17A CRP CD79A
14 toxoplasmosis 31.1 CD79A CD40LG CCR5
15 neuroretinitis 31.0 CRP CD4 ACE
16 lyme disease 31.0 IL17A HLA-DRB1 CRP CD40LG
17 vasculitis 30.9 IL17A CRP CD79A CD40LG APOH
18 aortitis 30.9 IL17A CRP CD4
19 iridocyclitis 30.9 IL17A CRP CD4 ACE
20 rubella 30.9 HLA-DRB1 HLA-C CD40LG
21 optic papillitis 30.9 CRP CD4 ACE
22 pustulosis of palm and sole 30.9 IL17A CRP CCR6
23 keratitis, hereditary 30.8 IL17A CD8A CD4 CCR6
24 exanthem 30.8 CRP CD8A CD4 CCR6 ALB ACE
25 human immunodeficiency virus type 1 30.8 HLA-C CD4 CD209 CCR5 B2M
26 chancroid 30.8 CD4 CCR6 CCR5
27 chorioretinitis 30.7 IL17A CRP CD8A CD4 ACE
28 membranous nephropathy 30.7 CD79A B2M ALB ACE
29 genital herpes 30.7 CD8A CD4 CCR6
30 nephrotic syndrome 30.7 IL17A CRP CD79A B2M ALB ACE
31 urethritis 30.7 CRP CD8A CD4
32 orchitis 30.6 FOXP3 CRP CD8A CD4
33 glomerulonephritis 30.6 FN1 CD79A CD40LG B2M ALB ACE
34 proteinuria, chronic benign 30.6 CD79A B2M ALB ACE
35 antiphospholipid syndrome 30.6 CRP CD79A CD40LG APOH
36 viral hepatitis 30.6 HLA-DRB1 FAS CRP CP ALB
37 aortic valve insufficiency 30.6 CRP ALB ACE
38 choroiditis 30.5 IL17A CD4 ACE
39 retinal vasculitis 30.5 CD4 CCR6 APOH ACE
40 dermatophytosis 30.5 IL17A CD4 CCR6
41 myelitis 30.5 IL17A CCR6 APOH
42 chagas disease 30.5 IL17A CD4 CCR5 ACE
43 pfeiffer syndrome 30.4 CD8A CD40LG CD4 CCR6
44 intermediate uveitis 30.4 HLA-DRB1 CCR6 CCR5
45 human immunodeficiency virus infectious disease 30.4 FAS CD8A CD79A CD4 CD209 CCR6
46 transverse myelitis 30.4 IL17A CCR6 APOH
47 vaginal discharge 30.4 CRP CD4 ALB
48 variola major 30.4 CD8A CD4
49 panuveitis 30.3 IL17A HLA-DRB1 CRP CD8A CD4 CCR6
50 leprosy 3 30.3 IL17A HLA-DRB1 FOXP3 CD8A CD4 CD209

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to Syphilis
Sources

Symptoms & Phenotypes for Syphilis

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UMLS symptoms related to Syphilis:


fever; pruritus; pelvic pain; syphilitic chancre; gummatous inflammation

MGI Mouse Phenotypes related to Syphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 ACE ALB APOH B2M CCR5 CCR6
2 hematopoietic system MP:0005397 10.25 ACE B2M CCR5 CCR6 CD209 CD4
3 immune system MP:0005387 10.2 ACE ALB B2M CCR5 CCR6 CD4
4 mortality/aging MP:0010768 10 ACE ALB APOH B2M CCR5 CD4
5 liver/biliary system MP:0005370 9.91 ACE ALB B2M CCR5 CD79A CP
6 neoplasm MP:0002006 9.5 ACE ALB B2M CCR5 CD79A FAS
7 renal/urinary system MP:0005367 9.23 ACE ALB CD40LG CD79A CD8A FAS
Sources

Drugs & Therapeutics for Syphilis

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Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
2
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
3
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
6
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
7 Anti-Bacterial Agents Phase 4
8 Penicillin G Procaine Phase 4
9 Penicillin G Benzathine Phase 4
10 penicillins Phase 4
11 Reverse Transcriptase Inhibitors Phase 4
12 Antiviral Agents Phase 4
13 Anti-HIV Agents Phase 4
14 Anti-Infective Agents Phase 4
15 Antiparasitic Agents Phase 4
16 Antimalarials Phase 4
17 Antiprotozoal Agents Phase 4
18
Methadone Approved Phase 3 76-99-3 4095
19
Azithromycin Approved Phase 3 83905-01-5 447043 55185
20
Heroin Phase 3 5462328
21 Sunflower Phase 3
22
Cefixime Approved, Investigational Phase 2 79350-37-1 5362065 54362
23
Sodium citrate Approved, Investigational Phase 1 68-04-2
24
Clemastine Approved, Investigational Phase 1 15686-51-8 26987
25
Dimethyl sulfoxide Approved, Vet_approved Phase 1 67-68-5 679
26
Citric acid Approved, Nutraceutical, Vet_approved Phase 1 77-92-9 311
27 Pharmaceutical Solutions Phase 1
28 Citrate Phase 1
29 Anticoagulants Phase 1
30 Dextrans Phase 1
31
Ethanol Approved 64-17-5 702
32
Sulfamethazine Approved, Investigational, Vet_approved 57-68-1 5327
33
tannic acid Approved 1401-55-4
34
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
35
sodium fluoride Approved 7681-49-4
36 Antibiotics, Antitubercular
37 Vaccines
38 Immunologic Factors
39 Hepatitis C Antibodies
40 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
41 Anti-Retroviral Agents
42 Listerine

Interventional clinical trials:

(show top 50) (show all 84)
# Name Status NCT ID Phase Drugs
1 Doctor of Medicine Unknown status NCT02857959 Phase 4 Benzathine Penicillin G
2 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Unknown status NCT02871505 Phase 4 Benzathine Penicillin G
3 Randomized, Clinical Trial to Compare the Serological Response Rates of Serofast Early Syphilis Cases Retreated With Three Doses Benzathine Penicillin and Absence of Any Retreatment Unknown status NCT02884115 Phase 4 benzathine penicillin
4 Syphilis Response to Higher Penicillin Dosage in HIV Co-Infected Patients Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
5 Delivering PrEP in Pregnancy Completed NCT03070600 Phase 4
6 A Phase 4 Comparative Trial of Benzathine Penicillin G 2.4 Million Units Administered as a Single Dose Versus Three Successive Weekly Doses for Treatment of Early Syphilis in Subjects With or Without HIV Infection Recruiting NCT03637660 Phase 4 Benzathine Penicillin
7 Syphilis Self-testing to Expand Test Uptake Among Men Who Have Sex With Men (SST) Recruiting NCT04480749 Phase 4
8 Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men Recruiting NCT03980223 Phase 4 Doxycycline Hyclate Delayed-Release 200 mg
9 PrEP and dPEP: Doxycycline Post-exposure Prophylaxis for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV Pre-exposure Prophylaxis Recruiting NCT04050540 Phase 4 Doxycycline
10 Use of Tenofovir/Emtricitabine With Immediate or Deferred Doxycycline 100mg PO Daily for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative Men Who Have Sex With Men: a Pilot Study of Dual Daily HIV and Syphilis PrEP. (The DuDHS Trial). Active, not recruiting NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
11 A Randomized, Placebo-controlled Trial of Oral Doxycycline for the Prevention of Syphilis in HIV-positive Men Who Have Sex With Men (MSM) Not yet recruiting NCT02864550 Phase 4 Doxycycline
12 Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in COLOMBIA Unknown status NCT02454816 Phase 2, Phase 3
13 A Randomized Community Intervention Trial on Reducing HIV Infection Among Drug Users Attending Methadone Maintenance Treatment(MMT) and Preventing Secondary Transmission From HIV Positive Clients to Their Sexual Partners in China Unknown status NCT01108614 Phase 3
14 Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
15 A COMMUNITY-BASED, RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE EFFICACY OF COMPREHENSIVE HIV/STIs INTERVENTION AMONG MEN WHO HAVE SEX WITH MEN IN 8 CITIES IN CHINA Unknown status NCT01068015 Phase 3
16 A Phase III Equivalence Trial of Azithromycin vs. Benzathine Penicillin for the Treatment of Early Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
17 Randomized Trial of Male Circumcision for HIV Prevention, Rakai, Uganda Completed NCT00425984 Phase 3
18 Randomized Trial to Evaluate Mirasol Whole Blood Pathogen Reduction Technology System to Reduce Malaria and Emerging Transfusion Transmitted Infections Recruiting NCT03737669 Phase 3
19 HoMBReS: A Lay Health Advisor Approach to Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
20 A Brief, Clinic-Based, Safer Sex Program for Young African-American Men Completed NCT01439503 Phase 2
21 A Randomized, Placebo-controlled, Double-blind Trial to Assess Expanded Safety, Acceptability and Preliminary Effectiveness of PC-515 (Lambda Carrageenan) for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2 Carraguard (PC-515)
22 A Trial to Assess Expanded Safety, Acceptability and Preliminary Effectiveness of Carraguardâ„¢ (PC-515) in Preventing STI/HIV Transmission Completed NCT00213018 Phase 2 Carraguard (PC-515)
23 Clinical Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis Recruiting NCT03660488 Phase 2 Cefixime 400 milligram Oral Capsule [Suprax];Benzathine Penicillin G
24 Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women Recruiting NCT03752112 Phase 1, Phase 2 Cefixime;Benzathine penicillin 2.4 million units
25 A Randomized, Placebo-controlled, Double-blind Trial to Assess Expanded Safety and Acceptability of Carraguardâ„¢ (PC-515) Vaginal Gel Among Heterosexual Couples in Chiang Rai Completed NCT00213057 Phase 1 Carraguard (PC-515)
26 Transplantation of Human Allogenic Cord Blood Mononuclear Stem Cells in Autism: Safety and Efficacy of the Method Active, not recruiting NCT04710810 Phase 1
27 Finding the Latent Treponema Pallidum of Syphilis With Serofast Status Unknown status NCT03754517
28 Comparison of Different Partner Notification Strategies After Antenatal Syphilis Screening Unknown status NCT02262390
29 The Study of Bacteriology and Pathogen Drug Sensitivity of Chronic Dacryocystitis Unknown status NCT03216642
30 A Methadone Maintenance Treatment Outcome Study in Three Provinces in China: Comparative Evaluation of the Impact of an Intensive Health Care Provider Training Program Combined With Expanded Services on Treatment Retention, Heroin Use, Methadone Dosing and HIV Risk Practices Unknown status NCT01315054
31 Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men (MSM) Unknown status NCT01300689
32 Video Tool to Promote Knowledge of Syphilis as Facilitator of HIV Transmission Completed NCT00553111
33 Video Tool to Promote Syphilis Knowledge and Testing in the Emergency Department Completed NCT00552539
34 Prevention of HIV and STDs in Drug Using Women Completed NCT01235091
35 Enhanced Syphilis Screening Among HIV-positive Men (ESSAHM): Evaluation of a Clinic-based Intervention Completed NCT02019043
36 A Randomized Control Study to Evaluate Novel Interventions to Reduce Risk Factors Associated With HIV, Neglected Tropical and Non-communicable Diseases Among Couples in Zambia Completed NCT02744586
37 Partner Notification Strategies for STI Control in Urban Peru Completed NCT01720641
38 Asymptomatic Sexually Transmitted Infections (STI) : Comparison of Two Screening Strategies Routine Screening Versus Screening as Reported by the Risks Taken by the Patient, in a Cohort of HIV Outpatients Men Who Have Sex With Men Completed NCT02413632
39 Multi-site Study of Rapid Diagnostic Syphilis Assays of Persons Attending STD Clinics in High Syphilis Morbidity Areas Completed NCT00300534
40 Preventing Congenital Syphilis Completed NCT02353117
41 Doxycycline Prophylaxis or Incentive Payments to Reduce Incident Syphilis Among HIV- Infected Men Who Have Sex With Men Who Continue to Engage in High Risk Sex: A Randomized, Controlled Pilot Study Completed NCT02257658 Doxycycyline
42 A Randomized Study to Compare Three Counseling Strategies and Evaluate the Efficacy of Reminders for Regular HIV, Hepatitis B and C, and Syphilis Testing Completed NCT02752152
43 Feasibility of Introducing an Onsite Test for Syphilis in the Package of Antenatal Care at the Rural Primary Health Care Level in Burkina Faso Completed NCT03156751
44 Pre-exposure Prophylaxis: A Miracle Drug or a Moral Hazard Completed NCT04325555 PrEP
45 Treponema Pallidum-specific Proteomic Changes in Patients With Incident Syphilis Infection: an Observational Study in Belgium Completed NCT02059525
46 Comparisons of Treatment Response to Standard Treatment With Penicillin Between HIV-infected and HIV-uninfected Patients With Syphilis Completed NCT01944358
47 Improving HIV Prevention and Sexual and Reproductive Health Care in High Risk Women in Rwanda Using Lessons Learnt From Previous Rinda Ubuzima Projects Completed NCT03045809
48 Behavioral Science Aspects of Rapid Test Acceptance Completed NCT01317784
49 Repeat STI Patients: Tailored Socio-Contextual Intervention to Reduce HIV Risk Completed NCT01510262
50 The Natural History of Anal Human Papillomavirus Infection and Anal Cellular Abnormalities in Homosexual Men Completed NCT02007421

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


ERYTHROMYCIN PWDR

Cochrane evidence based reviews: chancre

Sources

Genetic Tests for Syphilis

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Genetic tests related to Syphilis:

# Genetic test Affiliating Genes
1 Syphilis 29
Sources

Anatomical Context for Syphilis

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MalaCards organs/tissues related to Syphilis:

40
Skin, Eye, Tongue, Whole Blood, Spinal Cord, Prostate, Cervix
Sources

Publications for Syphilis

About this section

Articles related to Syphilis:

(show top 50) (show all 26133)
# Title Authors PMID Year
1
Small vessel occlusion and syphilis in patients with first-ever ischemic stroke. 42 61
33759975 2021
2
Epidemiological study in Brazilian women highlights that syphilis remains a public health problem. 42 61
33533807 2021
3
Repeat screening for syphilis in pregnancy as an alternative screening strategy in the UK: a cost-effectiveness analysis. 61 42
33444184 2020
4
Antiphospholipid antibodies, antiphospholipid syndrome and infections. 61 54
18295729 2008
5
[Antiphospholipid syndrome: pathophysiology and clinicobiological aspects]. 61 54
19469420 2008
6
Intrathecal antitreponemal antibody synthesis determination using the INNO-LIA Syphilis Score. 61 54
18204743 2007
7
Effect of genital ulcer disease on HIV-1 coreceptor expression in the female genital tract. 54 61
18008231 2007
8
Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis. 54 61
17299719 2007
9
Hysteroscopy in the evaluation of patients with recurrent pregnancy loss: a cohort study in a primary care population. 54 61
15809790 2004
10
Factor V Leiden mutation in Sneddon syndrome. 54 61
12765305 2003
11
Anti-beta2-glycoprotein I antibodies in pediatric systemic lupus erythematosus and antiphospholipid syndrome. 61 54
12209489 2002
12
Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. 61 54
11491498 2001
13
Antiphospholipid antibody syndrome. A literature review. 61 54
11367816 2001
14
Different types of antiphospholipid antibodies in AIDS: a comparison with syphilis and the antiphospholipid syndrome. 54 61
10554081 1999
15
[The antiphospholipid syndrome--yesterday, today, tomorrow]. 61 54
9623352 1998
16
Antiphospholipid antibodies: guidelines for determination. 61 54
19078229 1997
17
[The incidence of the antiphospholipid syndrome in the clinical and biological manifestations of systemic lupus erythematosus]. 61 54
9424663 1997
18
Update: antiphospholipid antibodies. 61 54
19078201 1997
19
Antibodies to beta2-glycoprotein I--a specific marker for the antiphospholipid syndrome. 61 54
9276526 1997
20
Lupus anticoagulants: diagnostic dilemma and clinical challenge. 54 61
10169622 1997
21
Autoantibodies to phospholipids and to the coagulation proteins in AIDS. 61 54
9184392 1997
22
Prevalence and clinical significance of IgG isotype anti-beta 2-glycoprotein I antibodies in antiphospholipid syndrome: a comparative study with anticardiolipin antibodies. 61 54
9142046 1997
23
Antiphospholipid antibodies and atherosclerosis. 54 61
8902778 1996
24
Reactivity to beta 2 glycoprotein I clearly differentiates anticardiolipin antibodies from antiphospholipid syndrome and syphilis. 54 61
8725711 1996
25
Anticardiolipin antibodies from syphilis and systemic lupus erythematosus induce leakage in cardiolipin vesicles. 54 61
8736113 1996
26
Prevalence of antiphospholipid antibodies in patients with ankylosing spondylitis. 54 61
8991987 1995
27
Antibodies to phospholipid-free beta 2-glycoprotein-I in patients with primary antiphospholipid syndrome. 61 54
8991988 1995
28
Comparison of the effects of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation. 61 54
7667838 1995
29
[A case of systemic lupus erythematosus associated with severe fibrinoid necrosis located mainly in the glomerular afferent arteriole]. 61 54
7699957 1995
30
Presence of multiple anti-phospholipid antibody specificities in a pediatric population. 54 61
8679908 1995
31
[Middle cerebral artery occlusion with unilateral moyamoya like vessels and with ruptured anterior cerebral artery aneurysm--its relation to the antiphospholipid antibody syndrome]. 54 61
7826715 1994
32
Differences in functional activity of anticardiolipin antibodies from patients with syphilis and those with antiphospholipid syndrome. 54 61
8063429 1994
33
Association of antimitochondrial antibodies type 5 and anti-beta 2 glycoprotein I antibodies in the antiphospholipid syndrome. 54 61
7799349 1994
34
Clinical and therapeutic aspects associated to phospholipid binding antibodies (lupus anticoagulant and anticardiolipin antibodies). 61 54
7988946 1994
35
[Primary antiphospholipid syndrome: clinical and biological study of 36 cases]. 61 54
8189783 1994
36
Postpartum myocardial infarction in a patient with antiphospholipid syndrome. 61 54
8155200 1994
37
Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. 61 54
7918046 1993
38
High prevalence of anti-cardiolipin antibody, C1q-, C3d-, and mRF-IgG immune complexes, and anti-nuclear antibody in hemophiliacs irrespective of infection with human immunodeficiency virus type 1. 61 54
8410668 1993
39
Lupoid sclerosis with antiphospholipid and antimyelin antibodies. 61 54
8496878 1993
40
Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2-glycoprotein I. 61 54
1522218 1992
41
Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. 54 61
1602135 1992
42
Antiphospholipid antibody syndrome: a case report and review of the literature. 54 61
1801188 1991
43
[Anticardiolipin antibodies in diffuse connective tissue diseases with IgG, IgM and IgA isotypes]. 61 54
2267732 1990
44
Vasculopathy associated with the antiphospholipid antibody syndrome. 61 54
2189163 1990
45
Biological true and false serological tests for syphilis: their relationship with anticardiolipin antibodies. 61 54
2340925 1990
46
THE HISTORY OF SYPHILIS IN THE XVI CENTURY AND THE PIVOTAL ROLE OF LUIGI LUIGINI IN THE RENAISSANCE 61
33535768 2021
47
Infectious Uveitis after Local Steroid and/or Methotrexate Injections at A Tertiary Referral Center in New Zealand: A Case Series. 61
33792480 2021
48
Clinical presentation of congenital syphilis in a rotavirus vaccine cohort study in Lusaka: a case series. 61
33789741 2021
49
[Induction of penicillin tolerance during pregnancy : Allergological opinion on the recommendation of the current Guidelines on Diagnosis and Treatment of Syphilis (AWMF Registry No. 059-002)]. 61
33655345 2021
50
The Estimated Lifetime Medical Cost of Syphilis in the United States. 61
33492088 2021
Sources

Variations for Syphilis

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Copy number variations for Syphilis from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 111152 17 35097918 35138441 Copy number ERBB2 Syphilis
Sources

Expression for Syphilis

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Search GEO for disease gene expression data for Syphilis.
Sources

Pathways for Syphilis

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Pathways related to Syphilis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.76 TPR IL17A HLA-DRB1 HLA-C FN1 CRP
2
Class I MHC mediated antigen processing and presentation 65
Show member pathways
 13.3 HLA-DRB1 HLA-C CD8A CD79A CD40LG CD4
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.17 TPR IL17A HLA-DRB1 HLA-C FN1 CD40LG
4
Measles 36
Show member pathways
 12.68 HLA-DRB1 HLA-C FAS CD209 B2M
5
T cell receptor signaling pathway 36
Show member pathways
 12.45 IL17A FAS CD8A CD40LG CD4 CCR5
6
Human T-cell leukemia virus 1 infection 36
12.19 HLA-DRB1 HLA-C CD4 B2M
7
Allograft rejection 1 36
Show member pathways
 12.02 IL17A HLA-DRB1 HLA-C FOXP3 FAS CD8A
8
NF-kappaB Signaling 4
12.01 IL17A FOXP3 FAS CD8A CD79A CD40LG
9
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
11.94 HLA-C CD8A CD40LG B2M
10
Cell adhesion molecules 36
11.94 HLA-DRB1 HLA-C CD8A CD40LG CD4
11
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.86 CD8A CD79A CD4 CD209
12
TCR signaling in naive CD4+ T cells 1
Show member pathways
 11.81 HLA-DRB1 CD8A CD4 B2M
13
IL12-mediated signaling events 1
Show member pathways
 11.71 HLA-DRB1 CD8A CD4 CCR5 B2M
14
Innate Lymphoid Cell Differentiation Pathways 64
11.66 IL17A CD8A CD4 CCR6
15
Dendritic Cells Developmental Lineage Pathway 64
11.61 CD8A CD4 CD209
16
CTLA4 Signaling 63
11.59 HLA-DRB1 CD8A CD4
17
IgA-Producing B Cells in the Intestine 64
11.53 FOXP3 CD40LG CCR6
18
Primary immunodeficiency 36
11.04 CD8A CD79A CD40LG CD4
Sources

GO Terms for Syphilis

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Cellular components related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.25 HLA-DRB1 HLA-C FAS CP CD8A CD79A
2 extracellular exosome GO:0070062 10.06 HLA-DRB1 HLA-C FN1 FAS CP B2M
3 extracellular space GO:0005615 9.96 IL17A HLA-DRB1 FN1 CRP CP CD40LG
4 extracellular region GO:0005576 9.93 IL17A FN1 FAS CRP CP CD8A
5 endoplasmic reticulum lumen GO:0005788 9.72 FN1 CP CD4 B2M ALB
6 cell surface GO:0009986 9.65 HLA-DRB1 HLA-C FAS CD40LG CD4 CD209
7 ER to Golgi transport vesicle membrane GO:0012507 9.54 HLA-DRB1 HLA-C B2M
8 MHC class I protein complex GO:0042612 9.46 HLA-C B2M
9 external side of plasma membrane GO:0009897 9.4 IL17A HLA-DRB1 FAS CD8A CD79A CD40LG

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.86 IL17A HLA-DRB1 HLA-C CD8A CD79A CD4
2 cellular protein metabolic process GO:0044267 9.84 FN1 CP B2M ALB
3 regulation of immune response GO:0050776 9.78 HLA-C CD8A CD40LG B2M
4 interferon-gamma-mediated signaling pathway GO:0060333 9.7 HLA-DRB1 HLA-C B2M
5 positive regulation of T cell proliferation GO:0042102 9.61 CD40LG CD4 CD209
6 T cell activation GO:0042110 9.58 FOXP3 CD8A CD4
7 positive regulation of monocyte differentiation GO:0045657 9.56 HLA-DRB1 CD4
8 T cell mediated immunity GO:0002456 9.55 FOXP3 CD8A
9 regulation of immunoglobulin production GO:0002637 9.51 FOXP3 CD40LG
10 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.5 HLA-C B2M ACE
11 adaptive immune response GO:0002250 9.5 IL17A HLA-DRB1 HLA-C CD8A CD79A CD4
12 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.49 HLA-C B2M
13 fusion of virus membrane with host plasma membrane GO:0019064 9.46 CD4 CCR5
14 antigen processing and presentation GO:0019882 9.46 HLA-DRB1 HLA-C CD8A CD209
15 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0032831 9.37 HLA-DRB1 FOXP3
16 immune response GO:0006955 9.32 IL17A HLA-DRB1 HLA-C FAS CD8A CD40LG

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.43 CD4 CD209 CCR5
2 coreceptor activity GO:0015026 9.33 CD8A CD4 CCR5
3 identical protein binding GO:0042802 9.32 FOXP3 FN1 FAS CRP CD79A CD4
4 peptide antigen binding GO:0042605 9.13 HLA-DRB1 HLA-C CD209
Sources

Sources for Syphilis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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