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Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Syphilis

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MalaCards integrated aliases for Syphilis:

Name: Syphilis 12 74 54 42 3 15 17 71
Chancre 43 17
Syphilitic Chancre 12

Classifications:

MalaCards categories:
Global: Infectious diseases Fetal diseases Rare diseases
Anatomical: Skin diseases Reproductive diseases Neuronal diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:4166
MeSH 43 D002601
SNOMED-CT 67 736686006
ICD10 32 A51.0 A53.9
UMLS 71 C0007939 C0039128
Sources

Summaries for Syphilis

About this section
MedlinePlus : 42 Syphilis is a sexually transmitted disease caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy. The early stage of syphilis usually causes a single, small, painless sore. Sometimes it causes swelling in nearby lymph nodes. If you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. Many people do not notice symptoms for years. Symptoms can go away and come back. The sores caused by syphilis make it easier to get or give someone HIV during sex. If you are pregnant, syphilis can cause complications, or you could lose your baby. In rare cases, syphilis causes serious health problems and even death. Syphilis is easy to cure with antibiotics if you catch it early. Correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex. Centers for Disease Control and Prevention

MalaCards based summary : Syphilis, also known as chancre, is related to late congenital syphilis and cardiovascular syphilis, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. The drugs Estradiol and Spironolactone have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC : 3 Syphilis is a sexually transmitted infection that can cause serious health problems if it is not treated. Syphilis is divided into stages (primary, secondary, latent, and tertiary). There are different signs and symptoms associated with each stage.

Wikipedia : 74 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

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Related Diseases for Syphilis

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Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1046)
# Related Disease Score Top Affiliating Genes
1 late congenital syphilis 34.8 DDX41 CRP CD40LG
2 cardiovascular syphilis 34.8 TPR DDX41
3 congenital syphilis 34.6 TPR MYH9 DDX41 CD79A CD40LG CD4
4 latent syphilis 34.5 TPR MYH9 DDX41 CD40LG CD4
5 primary syphilis 34.4 TPR MYH9 DDX41 CD40LG CD4
6 tertiary syphilis 34.3 TPR MYH9 DDX41 CRP CD40LG CD4
7 asymptomatic neurosyphilis 34.0 MYH9 CD40LG CD4
8 secondary syphilis 33.8 TPR MYH9 FN1 DDX41 CD79A CD40LG
9 tertiary neurosyphilis 33.8 MYH9 DDX41 CD40LG CD4
10 syphilitic meningitis 33.1 DDX41 CD40LG CD4
11 tabes dorsalis 32.9 MYH9 DDX41 CD4
12 mikulicz disease 32.3 CRP CD40LG CD4 CCR6
13 yaws 31.7 TPR MYH9 CD40LG
14 chlamydia 31.7 IL17A CRP CD79A CD40LG
15 toxoplasmosis 31.5 CD79A CD40LG CCR5
16 exanthem 31.4 CRP CD40LG CD4 CCR6 ACE
17 chorioretinitis 31.3 IL17A CD40LG CD4 ACE
18 lyme disease 31.3 IL17A HLA-DRB1 CRP CD40LG
19 rubella 31.3 HLA-DRB1 HLA-C CD40LG
20 vasculitis 31.2 IL17A CRP CD79A CD40LG APOH
21 orchitis 31.2 CRP CD40LG CD4
22 pustulosis of palm and sole 31.2 IL17A CRP CCR6
23 neuroretinitis 31.2 CRP CD40LG CD4 ACE
24 keratitis, hereditary 31.2 IL17A CD4 CCR6
25 leprosy 3 31.2 IL17A HLA-DRB1 CD40LG CD4 CD209 CCR6
26 human immunodeficiency virus type 1 31.2 HLA-C CD4 CD209 CCR5 B2M
27 aortitis 31.1 IL17A CRP CD40LG CD4
28 iridocyclitis 31.1 IL17A CRP CD40LG CD4 ACE
29 meningitis 31.1 IL17A CRP CD40LG CAT
30 urethritis 31.1 CRP CD40LG CD4
31 genital herpes 31.0 CD40LG CD4 CCR6 CCR5
32 trichomoniasis 31.0 CD40LG CD4 CCR5
33 membranous nephropathy 31.0 CD79A B2M ACE
34 immune deficiency disease 31.0 FAS CD79A CD40LG CD4 CD209 CCR6
35 viral hepatitis 31.0 HLA-DRB1 FAS CRP CP CD40LG
36 chancroid 31.0 CD40LG CD4 CCR6 CCR5
37 pityriasis rosea 31.0 HLA-DRB1 HLA-C CD40LG
38 bone inflammation disease 30.9 IL17A HLA-DRB1 CRP CD40LG CD4 CCR6
39 human immunodeficiency virus infectious disease 30.9 FAS CD79A CD4 CD209 CCR6 CCR5
40 glomerulonephritis 30.9 MYH9 FN1 CD79A CD40LG B2M ACE
41 antiphospholipid syndrome 30.9 CRP CD79A CD40LG APOH
42 optic papillitis 30.8 DDX41 CRP CD40LG CD4 ACE
43 pulmonary tuberculosis 30.8 HLA-DRB1 CRP CP CAT
44 dermatophytosis 30.8 IL17A CD4 CCR6
45 chickenpox 30.8 CRP CD40LG CD4 CCR6
46 myelitis 30.8 IL17A CD40LG CCR6 APOH
47 brucellosis 30.8 IL17A CRP CD40LG CAT
48 vaginal discharge 30.7 CRP CD40LG CD4
49 chagas disease 30.7 IL17A CD4 CCR5 ACE
50 panuveitis 30.7 IL17A HLA-DRB1 CRP CD40LG CD4 CCR6

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to Syphilis
Sources

Symptoms & Phenotypes for Syphilis

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UMLS symptoms related to Syphilis:


fever, pruritus, pelvic pain, syphilitic chancre, gummatous inflammation

MGI Mouse Phenotypes related to Syphilis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 ACE B2M CCR5 CCR6 CD4 CD40LG
2 homeostasis/metabolism MP:0005376 10.13 ACE APOH B2M CAT CCR5 CCR6
3 cardiovascular system MP:0005385 10.07 ACE B2M CCR5 CCR6 CD40LG CP
4 immune system MP:0005387 10 ACE B2M CCR5 CCR6 CD4 CD40LG
5 mortality/aging MP:0010768 9.8 ACE APOH B2M CAT CCR5 CD4
6 neoplasm MP:0002006 9.17 ACE B2M CAT CCR5 CD79A FAS
Sources

Drugs & Therapeutics for Syphilis

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Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 164)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
3
Polyestradiol phosphate Approved Phase 4 28014-46-2
4
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
5
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
6
Azithromycin Approved Phase 4 83905-01-5 447043 55185
7
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
8
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
9
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
10 Hormone Antagonists Phase 4
11 Estradiol 17 beta-cypionate Phase 4
12 Estradiol 3-benzoate Phase 4
13 Androgen Antagonists Phase 4
14 Penicillin G Benzathine Phase 4
15 Penicillin G Procaine Phase 4
16 Anti-Bacterial Agents Phase 4
17 penicillins Phase 4
18 Anti-Infective Agents Phase 4
19 Anti-HIV Agents Phase 4
20 Antiviral Agents Phase 4
21 Reverse Transcriptase Inhibitors Phase 4
22 Antiparasitic Agents Phase 4
23 Antiprotozoal Agents Phase 4
24 Antimalarials Phase 4
25
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
26
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
27
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
28
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
29
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
30 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
31
Nitrofurantoin Approved, Vet_approved Phase 3 67-20-9 5353830
32
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
33
carbamide peroxide Approved Phase 3 124-43-6
34
Acyclovir Approved Phase 3 59277-89-3 2022
35
Metronidazole Approved Phase 3 443-48-1 4173
36
leucovorin Approved Phase 3 58-05-9 6006 143
37
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
38
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
39
mometasone furoate Approved, Investigational, Vet_approved Phase 3 83919-23-7
40
acetic acid Approved Phase 3 64-19-7 176
41
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
42
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
43
Dihydroartemisinin Experimental, Investigational Phase 3 71939-50-9 6918483
44
Piperaquine Experimental, Investigational Phase 3 4085-31-8 5079497
45
Heroin Phase 3 5462328
46 Gastrointestinal Agents Phase 3
47 Methylprednisolone Acetate Phase 3
48 Antineoplastic Agents, Hormonal Phase 3
49 Antiemetics Phase 3
50 glucocorticoids Phase 3

Interventional clinical trials:

(show top 50) (show all 229)
# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage in HIV Co-Infected Patients Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Gender-Affirmative Medical Care to Improve HIV Treatment Cascade Among Transgender Women Completed NCT03757117 Phase 4 Feminizing hormone therapy
3 Doctor of Medicine Recruiting NCT02857959 Phase 4 Benzathine Penicillin G
4 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Recruiting NCT02871505 Phase 4 Benzathine Penicillin G
5 A Phase 4 Comparative Trial of Benzathine Penicillin G 2.4 Million Units Administered as a Single Dose Versus Three Successive Weekly Doses for Treatment of Early Syphilis in Subjects With or Without HIV Infection Recruiting NCT03637660 Phase 4 Benzathine Penicillin
6 Randomized, Clinical Trial to Compare the Serological Response Rates of Serofast Early Syphilis Cases Retreated With Three Doses Benzathine Penicillin and Absence of Any Retreatment Recruiting NCT02884115 Phase 4 benzathine penicillin
7 Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men Recruiting NCT03980223 Phase 4 Doxycycline Hyclate Delayed-Release 200 mg
8 PrEP and dPEP: Doxycycline Post-exposure Prophylaxis for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV Pre-exposure Prophylaxis Recruiting NCT04050540 Phase 4 Doxycycline
9 Hepatitis B Virus Vaccination in HIV-positive Patients and Individuals at High Risk for HIV Infection: an Open-label Randomized Clinical Trial Recruiting NCT03854630 Phase 4 Engerix-B
10 Use of Tenofovir/Emtricitabine With Immediate or Deferred Doxycycline 100mg PO Daily for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative Men Who Have Sex With Men: a Pilot Study of Dual Daily HIV and Syphilis PrEP. (The DuDHS Trial). Active, not recruiting NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
11 Delivering PrEP in Pregnancy Active, not recruiting NCT03070600 Phase 4 Universal PrEP Counseling;Targeted PrEP Counseling
12 Defining the Best Distribution Strategy of Azithromycin for Yaws Eradication (The Yaws 3 Trial) Active, not recruiting NCT03490123 Phase 4 R1-Total community treatment with azithromycin;R2-Total community treatment with azithromycin;R3-Total community treatment with azithromycin;R2-Total targeted treatment with azithromycin;R3-Total targeted treatment with azithromycin
13 A Randomized, Placebo-controlled Trial of Oral Doxycycline for the Prevention of Syphilis in HIV-positive Men Who Have Sex With Men (MSM) Not yet recruiting NCT02864550 Phase 4 Doxycycline
14 Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in COLOMBIA Unknown status NCT02454816 Phase 2, Phase 3
15 A Randomized Community Intervention Trial on Reducing HIV Infection Among Drug Users Attending Methadone Maintenance Treatment(MMT) and Preventing Secondary Transmission From HIV Positive Clients to Their Sexual Partners in China Unknown status NCT01108614 Phase 3
16 A COMMUNITY-BASED, RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE EFFICACY OF COMPREHENSIVE HIV/STIs INTERVENTION AMONG MEN WHO HAVE SEX WITH MEN IN 8 CITIES IN CHINA Unknown status NCT01068015 Phase 3
17 Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
18 Optic Neuritis Treatment Trial (ONTT) Unknown status NCT00000146 Phase 3 Methylprednisolone;Prednisone
19 Maternal Genitourinary Infections and Adverse Perinatal Outcomes in Sylhet District, Bangladesh Unknown status NCT01572532 Phase 3
20 A Phase III Equivalence Trial of Azithromycin vs. Benzathine Penicillin for the Treatment of Early Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
21 Single-dose Azithromycin Versus Penicillin G Benzathine for the Treatment of Yaws in Children Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
22 Randomized Trial of Male Circumcision for HIV Prevention, Rakai, Uganda Completed NCT00425984 Phase 3
23 A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Acyclovir for the Reduction of HIV Acquisition Among High-Risk HSV-2 Seropositive, HIV Seronegative Individuals Completed NCT00076232 Phase 3 Acyclovir;Acyclovir placebo
24 Impact of Episodic Acyclovir Therapy on Ulcer Duration and HIV Shedding From Genital Ulcers Among Men in South Africa Completed NCT00164424 Phase 2, Phase 3 Acyclovir
25 Strategies for the Prevention of HIV Infection and the Enhancement of Reproductive Health Among Adolescents in Rural Tanzania: MEMA Kwa Vijana Trial Completed NCT00248469 Phase 3
26 Randomized Trial to Evaluate Mirasol Whole Blood Pathogen Reduction Technology System to Reduce Malaria and Emerging Transfusion Transmitted Infections Recruiting NCT03737669 Phase 3
27 Effects of Metronidazole Plus Intermittent Preventive Treatment of Malaria in Pregnancy on Birth Outcomes: a Randomised Controlled Trial in Zambia Recruiting NCT04189744 Phase 3 IPTp-sulphadoxine-pyrimethamine plus metronidazole;IPTp-dihydroartemisinin-piperaquine plus metronidazole;IPTp-sulphadoxine-pyrimethamine
28 Efficacy of Convalescent Plasma Therapy in Patients With COVID-19: A Randomized Control Trial Recruiting NCT04425915 Phase 3
29 Impact of the Rapid Expansion of Pre-exposure Prophylaxis (PrEP) on HIV Incidence, in a Setting With High HIV Testing and Antiretroviral Treatment Coverage, to Achieve the Virtual Elimination of HIV Transmission by 2020: a NSW HIV Strategy Implementation Project Active, not recruiting NCT02870790 Phase 3 TDF/FTC
30 A Randomized, Controlled, Double-blind, Phase 3 Trial to Evaluate the Effects of Maternal or Neonatal Pneumococcal Conjugate Vaccination on Pneumococcal Carriage in Infants up to Nine Months of Age - The PROPEL Trial Active, not recruiting NCT02628886 Phase 3
31 A Multi-centre Randomised Controlled Trial Evaluating the Efficacy of the Four-component Meningococcal B Vaccine, 4CMenB (Bexsero®), in the Prevention of Neisseria Gonorrhoeae Infection in Gay and Bisexual Men Not yet recruiting NCT04415424 Phase 3
32 Effect of Autologous Cord Blood Mononuclear Cells for Prevention of Bronchopulmonary Dysplasia in Extremely Preterm Neonates: a Placebo-controlled Randomized Multicenter Trial Not yet recruiting NCT04440670 Phase 3
33 A Randomized Trial of Spectroscopy Versus Standard Care in Cervical Intraepithelial Neoplasia Terminated NCT00529464 Phase 3
34 Randomised Placebo Controlled Trial of Faecal Microbiota Transplantation in Irritable Bowel Syndrome Unknown status NCT02423421 Phase 2
35 HoMBReS: A Lay Health Advisor Approach to Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
36 Computer-assisted STD Partner Notification Completed NCT00207571 Phase 1, Phase 2
37 Development of a Methamphetamine Early Intervention Completed NCT01174654 Phase 1, Phase 2
38 A Randomized, Placebo-controlled, Double-blind Trial to Assess Expanded Safety, Acceptability and Preliminary Effectiveness of PC-515 (Lambda Carrageenan) for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2 Carraguard (PC-515)
39 Biobehavioral Interventions for HIV-negative Methamphetamine-using MSM Completed NCT00856323 Phase 2 Truvada
40 Randomized, Single-centre, Double-blind, Placebo-controlled, Phase I / IIa Study to Evaluate the Safety and Efficacy of Human Autologous Hair Follicle Dermal Sheath Cup Cells (DSCC) in Women and Men With Androgenetic Alopecia. Completed NCT01286649 Phase 1, Phase 2
41 A Trial to Assess Expanded Safety, Acceptability and Preliminary Effectiveness of Carraguardâ„¢ (PC-515) in Preventing STI/HIV Transmission Completed NCT00213018 Phase 2 Carraguard (PC-515)
42 Anti-Herpetic Treatment Associated With Syndromic Management of Genital Ulcer in Africa: Clinical and Biological Evaluation on HIV-1 and HSV-2 Shedding (ANRS 1212) Completed NCT00158483 Phase 2 Acyclovir (ACV)
43 Fecal Microbiota Transplantation by Colonoscopy for Recurrent C. Difficile Infection: an Open-label Randomized Clinical Trial Completed NCT02148601 Phase 2 Standard Antibiotic Therapy;Vancomycin (before randomization)
44 Adjunctive Therapy With Telmisartan Instituted With ART During Acute HIV Infection to Reduce the Establishment of CNS Reservoirs of HIV and Lymph Node Fibrosis Completed NCT02750059 Phase 2 TDF/3TC/EFV + Telmisartan;TDF/3TC/EFV only
45 Couples Based HIV/STI Prevention for Injecting Drug Users in Kazakhstan Completed NCT01690442 Phase 2
46 Intra-articular Injections of Platelet-rich Plasma in Patients With Knee Pain of Articular Cartilage Origin (Degenerative Chondropathy and Early OA). Completed NCT01747018 Phase 1, Phase 2
47 Randomized Clinical Trial: Single Versus Multiple-infusion Fecal Microbiota Transplantation for Severe Clostridium Difficile Infection Completed NCT03427229 Phase 2 Vancomycin (before randomization)
48 Phase II Pilot Study to Estimate the Adverse Events Associated With the Lock Solution When Used to Salvage Central Venous Catheter (CVC) in the Setting of a Central Line Associated Bloodstream Infection (CLABSI) Completed NCT01539343 Phase 2 Antimicrobial Solution
49 A Brief, Clinic-Based, Safer Sex Program for Young African-American Men Completed NCT01439503 Phase 2
50 AN OPEN LABEL, BALANCED, RANDOMIZED, TWO-TREATMENT, TWO-PERIOD, TWO-SEQUENCE, CROSSOVER, SINGLE ORAL DOSE, BIOEQUIVALENCE STUDY OF METFORMIN 1000 MG TABLETS MANUFACTURED BY SAVIPHARM J.S.C, VIETNAM AND GLUCOPHAGE® 1000 MG TABLETS MANUFACTURED BY MERCK SANTE S.A.S.2, RUE DU PRESSOIR VERT-45400 SEMOY-FRANCE AND BE REGISTERED IN VIETNAM IN HEALTHY, ADULT, HUMAN MALE SUBJECTS UNDER FASTING CONDITION Completed NCT01710553 Phase 2

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ERYTHROMYCIN PWDR

Cochrane evidence based reviews: chancre

Sources

Genetic Tests for Syphilis

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Sources

Anatomical Context for Syphilis

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MalaCards organs/tissues related to Syphilis:

40
Testes, Skin, Bone, Liver, Eye, Lung, Heart
Sources

Publications for Syphilis

About this section

Articles related to Syphilis:

(show top 50) (show all 24689)
# Title Authors PMID Year
1
Comparison of coronary artery bypass grafting and percutaneous coronary intervention for syphilitic coronary artery ostial lesions: A 4-year retrospective study. 61 42
32481278 2020
2
Infectious Proctitis. 42
32320571 2020
3
Painful penile ulcers and testicular pain in a 45-year-old HIV-positive man. 42
32205668 2020
4
Antiphospholipid antibodies, antiphospholipid syndrome and infections. 54 61
18295729 2008
5
[Antiphospholipid syndrome: pathophysiology and clinicobiological aspects]. 61 54
19469420 2008
6
Intrathecal antitreponemal antibody synthesis determination using the INNO-LIA Syphilis Score. 54 61
18204743 2007
7
Effect of genital ulcer disease on HIV-1 coreceptor expression in the female genital tract. 61 54
18008231 2007
8
Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis. 61 54
17299719 2007
9
Hysteroscopy in the evaluation of patients with recurrent pregnancy loss: a cohort study in a primary care population. 61 54
15809790 2004
10
Factor V Leiden mutation in Sneddon syndrome. 61 54
12765305 2003
11
Anti-beta2-glycoprotein I antibodies in pediatric systemic lupus erythematosus and antiphospholipid syndrome. 61 54
12209489 2002
12
Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. 54 61
11491498 2001
13
Antiphospholipid antibody syndrome. A literature review. 54 61
11367816 2001
14
Different types of antiphospholipid antibodies in AIDS: a comparison with syphilis and the antiphospholipid syndrome. 61 54
10554081 1999
15
[The antiphospholipid syndrome--yesterday, today, tomorrow]. 61 54
9623352 1998
16
Antiphospholipid antibodies: guidelines for determination. 61 54
19078229 1997
17
[The incidence of the antiphospholipid syndrome in the clinical and biological manifestations of systemic lupus erythematosus]. 61 54
9424663 1997
18
Update: antiphospholipid antibodies. 61 54
19078201 1997
19
Antibodies to beta2-glycoprotein I--a specific marker for the antiphospholipid syndrome. 61 54
9276526 1997
20
Lupus anticoagulants: diagnostic dilemma and clinical challenge. 54 61
10169622 1997
21
Autoantibodies to phospholipids and to the coagulation proteins in AIDS. 61 54
9184392 1997
22
Prevalence and clinical significance of IgG isotype anti-beta 2-glycoprotein I antibodies in antiphospholipid syndrome: a comparative study with anticardiolipin antibodies. 61 54
9142046 1997
23
Antiphospholipid antibodies and atherosclerosis. 61 54
8902778 1996
24
Reactivity to beta 2 glycoprotein I clearly differentiates anticardiolipin antibodies from antiphospholipid syndrome and syphilis. 61 54
8725711 1996
25
Anticardiolipin antibodies from syphilis and systemic lupus erythematosus induce leakage in cardiolipin vesicles. 61 54
8736113 1996
26
Prevalence of antiphospholipid antibodies in patients with ankylosing spondylitis. 54 61
8991987 1995
27
Antibodies to phospholipid-free beta 2-glycoprotein-I in patients with primary antiphospholipid syndrome. 61 54
8991988 1995
28
Comparison of the effects of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation. 54 61
7667838 1995
29
[A case of systemic lupus erythematosus associated with severe fibrinoid necrosis located mainly in the glomerular afferent arteriole]. 61 54
7699957 1995
30
Presence of multiple anti-phospholipid antibody specificities in a pediatric population. 54 61
8679908 1995
31
[Middle cerebral artery occlusion with unilateral moyamoya like vessels and with ruptured anterior cerebral artery aneurysm--its relation to the antiphospholipid antibody syndrome]. 54 61
7826715 1994
32
Differences in functional activity of anticardiolipin antibodies from patients with syphilis and those with antiphospholipid syndrome. 61 54
8063429 1994
33
Association of antimitochondrial antibodies type 5 and anti-beta 2 glycoprotein I antibodies in the antiphospholipid syndrome. 61 54
7799349 1994
34
Clinical and therapeutic aspects associated to phospholipid binding antibodies (lupus anticoagulant and anticardiolipin antibodies). 61 54
7988946 1994
35
[Primary antiphospholipid syndrome: clinical and biological study of 36 cases]. 61 54
8189783 1994
36
Postpartum myocardial infarction in a patient with antiphospholipid syndrome. 54 61
8155200 1994
37
Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. 61 54
7918046 1993
38
High prevalence of anti-cardiolipin antibody, C1q-, C3d-, and mRF-IgG immune complexes, and anti-nuclear antibody in hemophiliacs irrespective of infection with human immunodeficiency virus type 1. 61 54
8410668 1993
39
Lupoid sclerosis with antiphospholipid and antimyelin antibodies. 61 54
8496878 1993
40
Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2-glycoprotein I. 61 54
1522218 1992
41
Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. 61 54
1602135 1992
42
Antiphospholipid antibody syndrome: a case report and review of the literature. 54 61
1801188 1991
43
[Anticardiolipin antibodies in diffuse connective tissue diseases with IgG, IgM and IgA isotypes]. 61 54
2267732 1990
44
Vasculopathy associated with the antiphospholipid antibody syndrome. 61 54
2189163 1990
45
Biological true and false serological tests for syphilis: their relationship with anticardiolipin antibodies. 61 54
2340925 1990
46
Candida auris and endogenous panophthalmitis: clinical and histopathological features. 61
32462100 2020
47
Research status and perspectives for pathogenic spirochete vaccines. 61
32272157 2020
48
Enzyme-linked immunosorbent assay (ELISA) versus Venereal Disease Research Laboratory test (VDRL) and rapid plasma reagin test (RPR) for screening of syphilis in pregnant women. 61
32246772 2020
49
Quarterly screening optimizes detection of sexually transmitted infections when prescribing HIV preexposure prophylaxis. 61
32205724 2020
50
Improving sexual healthcare delivery for men in prison: A nurse-led initiative. 61
32155678 2020
Sources

Variations for Syphilis

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Copy number variations for Syphilis from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 111152 17 35097918 35138441 Copy number ERBB2 Syphilis
Sources

Expression for Syphilis

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Search GEO for disease gene expression data for Syphilis.
Sources

Pathways for Syphilis

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Pathways related to Syphilis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.12 TPR MYH9 IL17A HLA-DRB1 HLA-C FN1
2
PAK Pathway 63
Show member pathways
 13.07 MYH9 IL17A FAS CD40LG CD4 CCR6
3
Cytokine Signaling in Immune system 65
Show member pathways
 12.92 TPR IL17A HLA-DRB1 HLA-C FN1 CD40LG
4
Measles 36
Show member pathways
 12.61 HLA-DRB1 HLA-C FAS CD209 B2M
5
T cell receptor signaling pathway 36
Show member pathways
 12.37 IL17A FAS CD40LG CD4 CCR5
6
NF-kappaB Signaling 4
12.28 IL17A FAS CD79A CD40LG B2M
7
Allograft rejection 1 36
Show member pathways
 12.24 IL17A HLA-DRB1 HLA-C FAS CD40LG CD4
8
Human T-cell leukemia virus 1 infection 36
12.12 HLA-DRB1 HLA-C CD4 B2M
9
Cell adhesion molecules (CAMs) 36
11.88 HLA-DRB1 HLA-C CD40LG CD4
10
IL12-mediated signaling events 1
Show member pathways
 11.61 HLA-DRB1 CD4 CCR5 B2M
11
Innate Lymphoid Cells Differentiation 64
11.57 IL17A CD4 CCR6
12
Primary immunodeficiency 36
11.08 CD79A CD40LG CD4
Sources

GO Terms for Syphilis

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Cellular components related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.21 MYH9 HLA-DRB1 HLA-C FAS CP CD79A
2 extracellular exosome GO:0070062 10.02 MYH9 HLA-DRB1 HLA-C FN1 FAS CP
3 extracellular region GO:0005576 10 IL17A FN1 FAS CRP CP CD40LG
4 extracellular space GO:0005615 9.85 IL17A HLA-DRB1 FN1 CRP CP CD40LG
5 cell surface GO:0009986 9.65 HLA-DRB1 HLA-C FAS CD40LG CD4 CD209
6 ER to Golgi transport vesicle membrane GO:0012507 9.58 HLA-DRB1 HLA-C B2M
7 MHC class I protein complex GO:0042612 9.43 HLA-C B2M
8 external side of plasma membrane GO:0009897 9.36 IL17A HLA-DRB1 FAS CD79A CD40LG CD4

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.85 HLA-DRB1 HLA-C CD79A CD4 CD209 B2M
2 adaptive immune response GO:0002250 9.8 HLA-DRB1 HLA-C CD79A CD4 CD209
3 interferon-gamma-mediated signaling pathway GO:0060333 9.63 HLA-DRB1 HLA-C B2M
4 positive regulation of T cell proliferation GO:0042102 9.5 CD40LG CD4 CD209
5 positive regulation of monocyte differentiation GO:0045657 9.49 HLA-DRB1 CD4
6 positive regulation of viral entry into host cell GO:0046598 9.48 HLA-DRB1 CD4
7 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.43 HLA-C B2M
8 antigen processing and presentation GO:0019882 9.33 HLA-DRB1 HLA-C CD209
9 immune response GO:0006955 9.28 IL17A HLA-DRB1 HLA-C FAS CD40LG CD4
10 fusion of virus membrane with host plasma membrane GO:0019064 9.26 CD4 CCR5
11 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.13 HLA-C B2M ACE

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.33 CD4 CD209 CCR5
2 identical protein binding GO:0042802 9.28 FN1 FAS CRP CD79A CD4 CCR5
3 peptide antigen binding GO:0042605 9.13 HLA-DRB1 HLA-C CD209
Sources

Sources for Syphilis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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