Syphilis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SYP003 MIFTS: 60	Syphilis Categories: Bone diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Syphilis

MalaCards integrated aliases for Syphilis:

Name: Syphilis ¹¹ ⁷⁵ ²⁸ ⁵³ ⁴¹ ² ¹⁴ ¹⁶ ⁷¹ ³³

Chancre ⁴³ ¹⁶

Syphilitic Chancre ¹¹

Classifications:

MalaCards categories:
Global: Infectious diseases Fetal diseases Rare diseases
Anatomical: Skin diseases Immune diseases Reproductive diseases Neuronal diseases Bone diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Certain infectious and parasitic diseases

Infections with a predominantly sexual mode of transmission

Early syphilis

Primary genital syphilis

Other and unspecified syphilis

Syphilis, unspecified

ICD11: ³³

Certain infectious or parasitic diseases

Predominantly sexually transmitted infections

Syphilis

Syphilis, unspecified

External Ids:

Disease Ontology ¹¹ DOID:4166

MeSH ⁴³ D002601

SNOMED-CT ⁶⁸ 736686006

ICD10 ³¹ A51.0 A53.9

EFO ¹⁶ EFO_0007504 EFO_1001247

ICD11 ³³ 455894495 455894495/unspecified

UMLS ⁷¹ C0007939 C0039128

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Summaries for Syphilis

MedlinePlus: ⁴¹ Syphilis is a sexually transmitted disease caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy. The early stage of syphilis usually causes a single, small, painless sore. Sometimes it causes swelling in nearby lymph nodes. If you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. Many people do not notice symptoms for years. Symptoms can go away and come back. The sores caused by syphilis make it easier to get or give someone HIV during sex. If you are pregnant, syphilis can cause complications, or you could lose your baby. In rare cases, syphilis causes serious health problems and even death. Syphilis is easy to cure with antibiotics if you catch it early. Correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. If your or your partner is allergic to latex, you can use polyurethane condoms. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex. Centers for Disease Control and Prevention

MalaCards based summary: Syphilis, also known as chancre, is related to congenital syphilis and tertiary syphilis, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Disease and Innate Immune System. The drugs Tetracycline and Benzylpenicillin have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and whole blood, and related phenotypes are homeostasis/metabolism and nervous system

Disease Ontology: ¹¹ A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC: ² Syphilis is a sexually transmitted infection that can cause serious health problems if it is not treated. Syphilis is divided into stages (primary, secondary, latent, and tertiary). There are different signs and symptoms associated with each stage.

Wikipedia: ⁷⁵ Syphilis (/ˈsɪfɪlɪs/) is a sexually transmitted infection caused by the bacterium Treponema pallidum... more...

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Related Diseases for Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis	Late Congenital Syphilis
Primary Syphilis	Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1278)

#	Related Disease	Score	Top Affiliating Genes
1	congenital syphilis	33.1	CRP CD79A CD40LG CD4
2	tertiary syphilis	32.7	TNF MIR570 CRP CD4
3	secondary syphilis	32.6	TNF CRP CD4 CCR5
4	syphilitic meningitis	32.6	CRP CD4
5	late congenital syphilis	32.3	FOXP3 CRP
6	tertiary neurosyphilis	32.2	MIR570 CD4
7	uveitis	31.4	TNF IL17A HLA-DRB1 CCR5
8	exanthem	31.4	TNF IL17A CRP CD4
9	hepatitis b	31.3	TNF TLR2 HLA-DRB1 BCL2
10	posterior uveitis	31.1	TNF IL17A CD4
11	human immunodeficiency virus type 1	31.1	HLA-C CD4 CD209 CCR5 B2M
12	chlamydia	31.1	TNF TLR2 IL17A CRP CD79A CCR5
13	keratitis, hereditary	31.0	TNF TLR2 IL17A CD4
14	chorioretinitis	31.0	TNF IL17A CRP CD4
15	toxoplasmosis	30.9	TNF IL17A CD79A CD40LG CCR5
16	rubella	30.9	TNF HLA-DRB1 HLA-C CD40LG
17	choroiditis	30.9	TNF IL17A CRP CD4
18	optic papillitis	30.9	TNF CRP CD4
19	optic neuritis	30.9	TNF HLA-DRB1 CCR5
20	panuveitis	30.9	TNF IL17A HLA-DRB1 CRP CD4
21	anterior uveitis	30.8	TNF TLR2 IL17A HLA-DRB1 CRP CD4
22	lichen planus	30.8	TNF IL17A FOXP3
23	lyme disease	30.8	TNF TLR2 IL17A HLA-DRB1 CRP CD40LG
24	retinal vasculitis	30.8	TNF CD4 APOH
25	viral hepatitis	30.7	TLR2 HLA-DRB1 FAS CRP
26	human immunodeficiency virus infectious disease	30.7	TNF FAS CD79A CD4 CD209 CCR5
27	osteomyelitis	30.7	TNF TLR2 CRP
28	nephrotic syndrome	30.7	TNF IL17A FN1 CRP CD79A CD4
29	genital herpes	30.7	TNF TLR2 CD4 CCR5
30	myelitis	30.7	TNF IL17A APOH
31	leprosy 3	30.7	TNF TLR2 IL17A HLA-DRB1 HLA-C FOXP3
32	vasculitis	30.7	TNF IL17A HLA-DRB1 CRP CD79A CD40LG
33	leptospirosis	30.6	TNF TLR2 CRP
34	lymphadenitis	30.6	TNF FAS CRP CD209
35	alopecia areata	30.6	TNF IL17A HLA-DRB1 HLA-C FOXP3
36	granuloma annulare	30.6	TNF IL17A CD4
37	meningitis	30.6	TNF TLR2 IL17A FN1 CRP
38	vascular disease	30.6	TNF FN1 CRP CD40LG APOH
39	typhoid fever	30.6	TNF HLA-DRB1 CRP
40	dermatophytosis	30.6	TNF IL17A CD4
41	aortitis	30.6	TNF IL17A HLA-DRB1 CRP CD4
42	trichomoniasis	30.6	TNF CD4 CCR5
43	hepatitis a	30.6	TNF HLA-DRB1 CD4 CCR5
44	orchitis	30.6	TNF IL17A FOXP3 CRP CD4
45	pulmonary tuberculosis	30.5	TNF TLR2 HLA-DRB1 CRP CP
46	acquired immunodeficiency syndrome	30.5	TNF CRP CD79A CD40LG CD4 CCR5
47	iritis	30.5	TNF IL17A CRP CD4
48	bone inflammation disease	30.5	TNF TLR2 IL17A HLA-DRB1 FOXP3 CRP
49	alcohol use disorder	30.5	TNF CRP CD4
50	anogenital venereal wart	30.5	TNF TLR2 CD4

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):

Acute Cystitis	Deficiency Anemia
Hypertension, Essential	Schizophreniform Disorder

Graphical network of the top 20 diseases related to Syphilis:

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Symptoms & Phenotypes for Syphilis

UMLS symptoms related to Syphilis:

fever; pruritus; pelvic pain; syphilitic chancre; gummatous inflammation

MGI Mouse Phenotypes related to Syphilis:

⁴⁵ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.39	APOH B2M BCL2 CCR5 CD209 CD4
2	nervous system	MP:0003631	10.29	B2M BCL2 CCR5 CD4 CD40LG CD79A
3	cellular	MP:0005384	10.21	B2M BCL2 CCR5 CD209 CD4 CD40LG
4	liver/biliary system	MP:0005370	10.18	B2M CCR5 CD79A CP FAS FN1
5	immune system	MP:0005387	10.16	B2M BCL2 CCR5 CD209 CD4 CD40LG
6	digestive/alimentary	MP:0005381	10.14	B2M BCL2 CCR5 CD209 CD4 FAS
7	neoplasm	MP:0002006	10.13	B2M BCL2 CCR5 CD79A FAS FN1
8	endocrine/exocrine gland	MP:0005379	10.13	B2M BCL2 CD4 CD40LG FAS FOXP3
9	renal/urinary system	MP:0005367	10.1	BCL2 CD209 CD40LG CD79A FAS FOXP3
10	cardiovascular system	MP:0005385	10.1	B2M BCL2 CCR5 CD40LG CP CRP
11	hematopoietic system	MP:0005397	10.06	B2M BCL2 CCR5 CD209 CD4 CD40LG
12	mortality/aging	MP:0010768	9.86	APOH B2M BCL2 CCR5 CD209 CD4
13	integument	MP:0010771	9.36	B2M BCL2 CD4 CD40LG FAS FN1

Sources

Drugs & Therapeutics for Syphilis

Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Tetracycline

Approved, Vet_approved, Withdrawn

Phase 4

60-54-8

5353990

Benzylpenicillin

Approved, Vet_approved

Phase 4

61-33-6

5904

Procaine

Approved, Investigational, Vet_approved

Phase 4

59-46-1

4914

Doxycycline

Approved, Investigational, Vet_approved

Phase 4

564-25-0

54671203

Antiviral Agents

Phase 4

Anti-HIV Agents

Phase 4

Reverse Transcriptase Inhibitors

Phase 4

Penicillins

Phase 4

Penicillin G Procaine

Phase 4

Penicillin G Benzathine

Phase 4

Anti-Bacterial Agents

Phase 4

Anti-Infective Agents

Phase 4

Antiprotozoal Agents

Phase 4

Antiparasitic Agents

Phase 4

Antimalarials

Phase 4

Diamorphine

Approved, Illicit, Investigational

Phase 3

561-27-3

5462328

Azithromycin

Approved

Phase 3

83905-01-5

447043

Cefixime

Approved, Investigational

Phase 3

79350-37-1

5362065

Antibiotics, Antitubercular

Phase 3

Amoxicillin

Approved, Vet_approved

Phase 1

26787-78-0

33613

Probenecid

Approved, Investigational

Phase 1

57-66-9

4911

Antirheumatic Agents

Phase 1

Ethanol

Approved

64-17-5

702

Benzocaine

Approved, Investigational

1994-09-7, 94-09-7

2337

Tannic acid

Approved

1401-55-4

16129878 16129778

Sulfamethazine

Approved, Investigational, Vet_approved

57-68-1

5327

Racivir

Approved, Investigational

143491-57-0, 143491-54-7

60877

Methadone

Approved

76-99-3, 1095-90-5

4095

Linezolid

Approved, Investigational

Early Phase 1

165800-03-3

441401

Sodium fluoride

Approved

7681-49-4

Tenofovir

Experimental, Investigational

147127-20-6, 202138-50-9

464205 6398764

Vaccines

Immunologic Factors

Hepatitis C Antibodies

Analgesics

Anti-Inflammatory Agents, Non-Steroidal

Analgesics, Non-Narcotic

Anti-Inflammatory Agents

Chrysarobin

Anti-Retroviral Agents

Analgesics, Opioid

Listerine

Interventional clinical trials:

(show top 50) (show all 77)

#	Name	Status	NCT ID	Phase	Drugs
1	Use of Tenofovir/Emtricitabine With Immediate or Deferred Doxycycline 100mg PO Daily for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative Men Who Have Sex With Men: a Pilot Study of Dual Daily HIV and Syphilis PrEP. (The DuDHS Trial).	Unknown status	NCT02844634	Phase 4	Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
2	A Randomized, Placebo-controlled Trial of Oral Doxycycline for the Prevention of Syphilis in HIV-positive Men Who Have Sex With Men (MSM)	Unknown status	NCT02864550	Phase 4	Doxycycline
3	Randomized, Clinical Trial to Compare the Serological Response Rates of Serofast Early Syphilis Cases Retreated With Three Doses Benzathine Penicillin and Absence of Any Retreatment	Unknown status	NCT02884115	Phase 4	benzathine penicillin
4	Doctor of Medicine	Unknown status	NCT02857959	Phase 4	Benzathine Penicillin G
5	The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings	Unknown status	NCT02871505	Phase 4	Benzathine Penicillin G
6	Syphilis Self-testing to Expand Test Uptake Among Men Who Have Sex With Men (SST)	Completed	NCT04480749	Phase 4
7	Syphilis Response to Higher Penicillin Dosage in HIV Co-Infected Patients	Completed	NCT02611765	Phase 4	Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
8	A Phase 4 Comparative Trial of Benzathine Penicillin G 2.4 Million Units Administered as a Single Dose Versus Three Successive Weekly Doses for Treatment of Early Syphilis in Subjects With or Without HIV Infection	Recruiting	NCT03637660	Phase 4	Benzathine Penicillin
9	PrEP and dPEP: Doxycycline Post-exposure Prophylaxis for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV Pre-exposure Prophylaxis	Active, not recruiting	NCT04050540	Phase 4	Doxycycline
10	Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men	Active, not recruiting	NCT03980223	Phase 4	Doxycycline Hyclate Delayed-Release 200 mg
11	A COMMUNITY-BASED, RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE EFFICACY OF COMPREHENSIVE HIV/STIs INTERVENTION AMONG MEN WHO HAVE SEX WITH MEN IN 8 CITIES IN CHINA	Unknown status	NCT01068015	Phase 3
12	A Randomized Community Intervention Trial on Reducing HIV Infection Among Drug Users Attending Methadone Maintenance Treatment(MMT) and Preventing Secondary Transmission From HIV Positive Clients to Their Sexual Partners in China	Unknown status	NCT01108614	Phase 3
13	Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and the Community	Unknown status	NCT00124878	Phase 3
14	A Phase III Equivalence Trial of Azithromycin vs. Benzathine Penicillin for the Treatment of Early Syphilis	Completed	NCT00031499	Phase 3	Azithromycin;Benzathine Penicillin;Doxycycline
15	Randomized Trial of Male Circumcision for HIV Prevention, Rakai, Uganda	Completed	NCT00425984	Phase 3
16	Oral and Neuro-Penetrative Alternative Antibiotics for Patients With Syphilis	Recruiting	NCT05069974	Phase 3	Linezolid;Benzathine Penicilllin G
17	A Randomized Non-Inferiority Clinical Trial of Doxycyline Vs BPG for Early Syphilis	Recruiting	NCT04838717	Phase 3	BPG;Doxycycline
18	Clinical Trial Comparing the Effectiveness of Cefixime Versus Penicillin G for Treatment of Early Syphilis	Recruiting	NCT04958122	Phase 3	Cefixime 400mg;benzathine penicillin
19	Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women	Unknown status	NCT03752112	Phase 1, Phase 2	Cefixime;Benzathine penicillin 2.4 million units
20	Clinical Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis	Completed	NCT03660488	Phase 2	Cefixime 400 milligram Oral Capsule [Suprax];Benzathine Penicillin G
21	A Randomized, Placebo-controlled, Double-blind Trial to Assess Expanded Safety, Acceptability and Preliminary Effectiveness of PC-515 (Lambda Carrageenan) for Vaginal Use as a Possible Microbicide	Completed	NCT00213031	Phase 2	Carraguard (PC-515)
22	HoMBReS: A Lay Health Advisor Approach to Sexually Transmitted Disease Prevention	Completed	NCT00207506	Phase 1, Phase 2
23	A Trial to Assess Expanded Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing STI/HIV Transmission	Completed	NCT00213018	Phase 2	Carraguard (PC-515)
24	A Brief, Clinic-Based, Safer Sex Program for Young African-American Men	Completed	NCT01439503	Phase 2
25	A Randomized, Placebo-controlled, Double-blind Trial to Assess Expanded Safety and Acceptability of Carraguard™ (PC-515) Vaginal Gel Among Heterosexual Couples in Chiang Rai	Completed	NCT00213057	Phase 1	Carraguard (PC-515)
26	A Rational Approach to the Identification of New Treatment Options to Prevent Congenital Syphilis: Phase 1 Study of the Pharmacokinetics of High Dose Amoxicillin With and Without Probenecid in Pregnant Women	Not yet recruiting	NCT05309928	Phase 1	Amoxicillin
27	Descriptive Cohort of Acquired Syphlis by Non Sexual Contact	Unknown status	NCT04455425
28	Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases in Context of ETMIplus Program, OPS/OMS. Multicentric Study	Unknown status	NCT04084379
29	Finding the Latent Treponema Pallidum of Syphilis With Serofast Status	Unknown status	NCT03754517
30	Comparison of Different Partner Notification Strategies After Antenatal Syphilis Screening	Unknown status	NCT02262390
31	A Methadone Maintenance Treatment Outcome Study in Three Provinces in China: Comparative Evaluation of the Impact of an Intensive Health Care Provider Training Program Combined With Expanded Services on Treatment Retention, Heroin Use, Methadone Dosing and HIV Risk Practices	Unknown status	NCT01315054
32	Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men (MSM)	Unknown status	NCT01300689
33	Multi-site Study of Rapid Diagnostic Syphilis Assays of Persons Attending STD Clinics in High Syphilis Morbidity Areas	Completed	NCT00300534
34	Comparisons of Treatment Response to Standard Treatment With Penicillin Between HIV-infected and HIV-uninfected Patients With Syphilis	Completed	NCT01944358
35	Congenital Syphilis at Third-level Pediatric Hospital. A Prospective Cohort With Retrospective Evaluation Study of the Last Three Decades.	Completed	NCT04137601
36	Preventing Congenital Syphilis	Completed	NCT02353117
37	Whole Genome Sequencing of Syphilis Using Routine Clinical Samples	Completed	NCT03709862
38	Enhanced Syphilis Screening Among HIV-positive Men (ESSAHM): Evaluation of a Clinic-based Intervention	Completed	NCT02019043
39	Video Tool to Promote Syphilis Knowledge and Testing in the Emergency Department	Completed	NCT00552539
40	A Randomized Study to Compare Three Counseling Strategies and Evaluate the Efficacy of Reminders for Regular HIV, Hepatitis B and C, and Syphilis Testing	Completed	NCT02752152
41	Video Tool to Promote Knowledge of Syphilis as Facilitator of HIV Transmission	Completed	NCT00553111
42	Doxycycline Prophylaxis or Incentive Payments to Reduce Incident Syphilis Among HIV- Infected Men Who Have Sex With Men Who Continue to Engage in High Risk Sex: A Randomized, Controlled Pilot Study	Completed	NCT02257658		Doxycycyline
43	Treponema Pallidum-specific Proteomic Changes in Patients With Incident Syphilis Infection: an Observational Study in Belgium	Completed	NCT02059525
44	Lumbar Puncture and Syphilis Outcome	Completed	NCT02031146
45	Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in COLOMBIA	Completed	NCT02454816
46	Utilization of the Community Popular Opinion Leader (C-POL) Model to Achieve Syphilis Elimination in Alabama	Completed	NCT00260754
47	A Community-Based Intervention With Popular Opinion Leaders (C-POL) in Texas to Achieve Syphilis Elimination	Completed	NCT00260715
48	Field Performance Evaluation of Dual Rapid HIV & Syphilis Tests in Zambia	Completed	NCT02445846
49	Feasibility of Introducing an Onsite Test for Syphilis in the Package of Antenatal Care at the Rural Primary Health Care Level in Burkina Faso	Completed	NCT03156751
50	Evaluation of the MBio Combined Syphilis/HIV Point-of-Care Diagnostic Test	Completed	NCT01530672

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

ERYTHROMYCIN PWDR

Cochrane evidence based reviews: chancre

Sources

Genetic Tests for Syphilis

Genetic tests related to Syphilis:

#	Genetic test	Affiliating Genes
1	Syphilis ²⁸

Sources

Anatomical Context for Syphilis

Organs/tissues related to Syphilis:

MalaCards : Skin, Heart, Whole Blood, Brain, Liver, Bone, Eye

Sources

Publications for Syphilis

Articles related to Syphilis:

(show top 50) (show all 27739)

#	Title	Authors	PMID	Year
1	HIV and syphilis knowledge, perceptions, and practices among Myanmar migrant workers in Samut Sakhon Province, Thailand. ⁶² ⁴¹	Paloga A...Soonthornworasiri N	36443736	2022
2	Determinants of gestational syphilis among women attending prenatal care programs in the Brazilian Amazon. ⁶² ⁴¹	Uchoa TLDA...Ferreira GRON	36438302	2022
3	Syphilis in pregnancy and congenital syphilis: women's experiences from the perspective of symbolic interactionism. ⁶² ⁴¹	Vicente JB...Furtado MCC	36449977	2022
4	Antiphospholipid antibodies, antiphospholipid syndrome and infections. ⁵³ ⁶²	Sene D...Cacoub P	18295729	2008
5	[Antiphospholipid syndrome: pathophysiology and clinicobiological aspects]. ⁵³ ⁶²	Ksouri H...Bejaoui M	19469420	2008
6	Intrathecal antitreponemal antibody synthesis determination using the INNO-LIA Syphilis Score. ⁵³ ⁶²	Kotnik V...Potocnik M	18204743	2007
7	Effect of genital ulcer disease on HIV-1 coreceptor expression in the female genital tract. ⁵³ ⁶²	Sheffield JS...Norgard MV	18008231	2007
8	Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis. ⁵³ ⁶²	Salazar JC...Radolf JD	17299719	2007
9	Hysteroscopy in the evaluation of patients with recurrent pregnancy loss: a cohort study in a primary care population. ⁵³ ⁶²	Ventolini G...Gruber J	15809790	2004
10	Factor V Leiden mutation in Sneddon syndrome. ⁵³ ⁶²	Besnier R...Piette JC	12765305	2003
11	Anti-beta2-glycoprotein I antibodies in pediatric systemic lupus erythematosus and antiphospholipid syndrome. ⁵³ ⁶²	von Scheven E...Elder ME	12209489	2002
12	Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. ⁵³ ⁶²	Santiago M...Gharavi A	11491498	2001
13	Antiphospholipid antibody syndrome. A literature review. ⁵³ ⁶²	Lao M...Foss C	11367816	2001
14	Different types of antiphospholipid antibodies in AIDS: a comparison with syphilis and the antiphospholipid syndrome. ⁵³ ⁶²	de Larranaga GF...Alonso BS	10554081	1999
15	[The antiphospholipid syndrome--yesterday, today, tomorrow]. ⁵³ ⁶²	Stefanovic D...Popovic M	9623352	1998
16	Antiphospholipid antibodies: guidelines for determination. ⁵³ ⁶²	Cervera R...Asherson RA	19078229	1997
17	Update: antiphospholipid antibodies. ⁵³ ⁶²	Sammaritano LR	19078201	1997
18	[The incidence of the antiphospholipid syndrome in the clinical and biological manifestations of systemic lupus erythematosus]. ⁵³ ⁶²	Sanchez Rodriguez A...Portugal Alvarez J	9424663	1997
19	Antibodies to beta2-glycoprotein I--a specific marker for the antiphospholipid syndrome. ⁵³ ⁶²	Guerin J...Jackson J	9276526	1997
20	Lupus anticoagulants: diagnostic dilemma and clinical challenge. ⁵³ ⁶²	Triplett DA	10169622	1997
21	Prevalence and clinical significance of IgG isotype anti-beta 2-glycoprotein I antibodies in antiphospholipid syndrome: a comparative study with anticardiolipin antibodies. ⁵³ ⁶²	Sanmarco M...Bernard D	9142046	1997
22	Autoantibodies to phospholipids and to the coagulation proteins in AIDS. ⁵³ ⁶²	Abuaf N...Rozenbaum W	9184392	1997
23	Antiphospholipid antibodies and atherosclerosis. ⁵³ ⁶²	Vaarala O	8902778	1996
24	Reactivity to beta 2 glycoprotein I clearly differentiates anticardiolipin antibodies from antiphospholipid syndrome and syphilis. ⁵³ ⁶²	Forastiero RR...Carreras LO	8725711	1996
25	Anticardiolipin antibodies from syphilis and systemic lupus erythematosus induce leakage in cardiolipin vesicles. ⁵³ ⁶²	Gremiao MP...Chaimovich H	8736113	1996
26	Prevalence of antiphospholipid antibodies in patients with ankylosing spondylitis. ⁵³ ⁶²	Juanola X...Roig-Escofet D	8991987	1995
27	Antibodies to phospholipid-free beta 2-glycoprotein-I in patients with primary antiphospholipid syndrome. ⁵³ ⁶²	Cabral AR...Alarcon-Segovia D	8991988	1995
28	Comparison of the effects of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation. ⁵³ ⁶²	Campbell AL...Harris EN	7667838	1995
29	[A case of systemic lupus erythematosus associated with severe fibrinoid necrosis located mainly in the glomerular afferent arteriole]. ⁵³ ⁶²	Morioka S...Ota Z	7699957	1995
30	Presence of multiple anti-phospholipid antibody specificities in a pediatric population. ⁵³ ⁶²	Beaman KD...O'Gorman MR	8679908	1995
31	[Middle cerebral artery occlusion with unilateral moyamoya like vessels and with ruptured anterior cerebral artery aneurysm--its relation to the antiphospholipid antibody syndrome]. ⁵³ ⁶²	Inoue R...Hori S	7826715	1994
32	Association of antimitochondrial antibodies type 5 and anti-beta 2 glycoprotein I antibodies in the antiphospholipid syndrome. ⁵³ ⁶²	Laperche S...Homberg JC	7799349	1994
33	Differences in functional activity of anticardiolipin antibodies from patients with syphilis and those with antiphospholipid syndrome. ⁵³ ⁶²	Pierangeli SS...Harris EN	8063429	1994
34	Clinical and therapeutic aspects associated to phospholipid binding antibodies (lupus anticoagulant and anticardiolipin antibodies). ⁵³ ⁶²	Ordi-Ros J...Monasterio J	7988946	1994
35	[Primary antiphospholipid syndrome: clinical and biological study of 36 cases]. ⁵³ ⁶²	Vivancos J...Ingelmo M	8189783	1994
36	Postpartum myocardial infarction in a patient with antiphospholipid syndrome. ⁵³ ⁶²	Thorp JM...Fann B	8155200	1994
37	Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. ⁵³ ⁶²	Matsuda J...Tsukamoto M	7918046	1993
38	High prevalence of anti-cardiolipin antibody, C1q-, C3d-, and mRF-IgG immune complexes, and anti-nuclear antibody in hemophiliacs irrespective of infection with human immunodeficiency virus type 1. ⁵³ ⁶²	Matsuda J...Kinoshita T	8410668	1993
39	Lupoid sclerosis with antiphospholipid and antimyelin antibodies. ⁵³ ⁶²	Marullo S...Oksenhendler E	8496878	1993
40	Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2-glycoprotein I. ⁵³ ⁶²	Roubey RA...Winfield JB	1522218	1992
41	Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. ⁵³ ⁶²	Matsuura E...Koike T	1602135	1992
42	Antiphospholipid antibody syndrome: a case report and review of the literature. ⁵³ ⁶²	Weaver CA	1801188	1991
43	[Anticardiolipin antibodies in diffuse connective tissue diseases with IgG, IgM and IgA isotypes]. ⁵³ ⁶²	Hrncir Z...Chylkova V	2267732	1990
44	Vasculopathy associated with the antiphospholipid antibody syndrome. ⁵³ ⁶²	Bowles CA	2189163	1990
45	Biological true and false serological tests for syphilis: their relationship with anticardiolipin antibodies. ⁵³ ⁶²	Bernard C...Didierjean L	2340925	1990
46	Microfluidic electrochemical device for real-time culturing and interference-free detection of Escherichia coli. ⁶²	Fande S...Goel S	36442949	2023
47	Effects of marriage equality legislation on sexual health of the US population. ⁶²	Nikolaou D	36165350	2023
48	High prevalence of vitamin D deficiency in HIV-infected individuals in comparison with the general population across Punjab province, Pakistan. ⁶²	Kanwal W...Rehman A	36387030	2023
49	Primary syphilis presenting as a painful unilateral inguinal lymphadenopathy, without cutaneous manifestations, in a 71-year-old Japanese man: A case report. ⁶²	Yorita K...Kumon T	36388614	2023
50	A monkeypox virus infection mimicking primary syphilis. ⁶²	Turco M...Pisano L	36005947	2022

Sources

Genes for Syphilis

Genes related to Syphilis (0 elite genes):

(show all 33)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	APOH	Apolipoprotein H	Protein Coding	23.55	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10554081 2340925 7918046 (more) 7667838 8736113 8063429 11491498 1801188 8496878 9424663 11367816 19078229 8155200 9184392 8902778 8679908 7988946 8410668 12765305 12209489 9623352 8991988 7799349 19078201 8991987 7826715 19469420 10169622 18295729 9142046 8725711 2267732 9276526 15809790 18204743 2189163 1602135 1522218 8189783 7699957
2	TNF	Tumor Necrosis Factor	Protein Coding	13.85	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	TLR2	Toll Like Receptor 2	Protein Coding	13.19	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	IL17A	Interleukin 17A	Protein Coding	12.98	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	FN1	Fibronectin 1	Protein Coding	12.98	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	B2M	Beta-2-Microglobulin	Protein Coding	12.79	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
7	CP	Ceruloplasmin	Protein Coding	12.61	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
8	CD209	CD209 Molecule	Protein Coding	12.57	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
9	CD79A	CD79a Molecule	Protein Coding	12.54	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
10	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	12.14	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
11	CD40LG	CD40 Ligand	Protein Coding	12.05	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	FOXP3	Forkhead Box P3	Protein Coding	11.81	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	HLA-C	Major Histocompatibility Complex, Class I, C	Protein Coding	11.6	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	BCL2	BCL2 Apoptosis Regulator	Protein Coding	11.59	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	FAS	Fas Cell Surface Death Receptor	Protein Coding	10.82	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	10.03	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	CD4	CD4 Molecule	Protein Coding	8.44	DISEASES inferred ¹⁴
18	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	8.35	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18008231 17299719
19	MIR570	MicroRNA 570	RNA Gene	8.14	DISEASES inferred ¹⁴ ¹⁴
20	CRP	C-Reactive Protein	Protein Coding	7.86	DISEASES inferred ¹⁴
21	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.57	DISEASES inferred ¹⁴ ¹⁴
22	TPR	Translocated Promoter Region, Nuclear Basket Protein	Protein Coding	7.42	DISEASES inferred ¹⁴
23	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	7.37	GeneCards inferred via : Publications (show sections)
24	ACE	Angiotensin I Converting Enzyme	Protein Coding	7.29	DISEASES inferred ¹⁴
25	CAT	Catalase	Protein Coding	7.2	GeneCards inferred via : Publications (show sections)
26	KIR2DS4	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 4	Protein Coding	7.2	GeneCards inferred via : Publications (show sections)
27	LACTB	Lactamase Beta	Protein Coding	7.2	GeneCards inferred via : Publications (show sections)
28	MIR142	MicroRNA 142	RNA Gene	7.2	GeneCards inferred via : Publications (show sections)
29	NLRP12	NLR Family Pyrin Domain Containing 12	Protein Coding	7.2	GeneCards inferred via : Publications (show sections)
30	ALB	Albumin	Protein Coding	7	DISEASES inferred ¹⁴
31	CD8A	CD8a Molecule	Protein Coding	6.95	DISEASES inferred ¹⁴
32	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	6.9	DISEASES inferred ¹⁴
33	PRTN3	Proteinase 3	Protein Coding	6.84	DISEASES inferred ¹⁴

Sources

Variations for Syphilis

Copy number variations for Syphilis from CNVD:

⁶

#	CNVD ID	Chromosome	Start	End	Type	Gene Symbol	CNVD Disease
1	111152	17	35097918	35138441	Copy number	ERBB2	Syphilis

Sources

Expression for Syphilis

Search GEO for disease gene expression data for Syphilis.

Sources

Pathways for Syphilis

Pathways related to Syphilis according to GeneCards Suite gene sharing:

(show all 35)

#	Super pathways	Score	Top Affiliating Genes
1	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.75	TLR2 IL17A HLA-C FN1 CP CD79A
2	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.72	TNF TLR2 IL17A HLA-DRB1 HLA-C FN1
3	Class I MHC mediated antigen processing and presentation ⁶⁶ Show member pathways Adaptive Immune System ⁶⁶ Antigen processing: Ubiquitination and Proteasome degradation ⁶⁶ Neddylation ⁶⁶	13.44	TLR2 HLA-DRB1 HLA-C CD79A CD40LG CD4
4	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.3	TNF TLR2 IL17A FAS CD40LG CD4
5	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.2	BCL2 CCR5 CD4 CD40LG FAS IL17A
6	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.04	B2M BCL2 CCR5 CD4 CD40LG FN1
7	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis ⁷⁴ Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis modulation by HSP70 ⁷⁴ Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ Ceramide signaling pathway ⁶¹ DR3 Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef: Negative effector of Fas and TNF-alpha ⁶¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF Signaling ⁶⁴ TNF-related weak inducer of apoptosis (TWEAK) signaling pathway ⁷⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.83	TNF FN1 FAS CD4 CCR5 BCL2
8	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.78	BCL2 CD209 FAS TLR2 TNF
9	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.57	TNF FAS CD40LG CD4 CCR5
10	TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions ⁶⁵ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ TNFs bind their physiological receptors ⁶⁶ TRAF Pathway ⁶⁴	12.52	TNF TLR2 FAS CD40LG BCL2
11	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.5	TNF IL17A FN1 CD4 BCL2
12	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.35	TNF TLR2 FN1 FAS
13	Apoptosis and Autophagy ³ Show member pathways Activation and oligomerization of BAK protein ⁶⁶ AIF Pathway ⁶⁴ Nanomaterial induced apoptosis ⁷⁴ Pro-survival signaling of neuroprotectin D1 ⁷⁴ vRNA Synthesis ⁶⁶	12.28	TNF FAS CD40LG BCL2
14	NF-kappaB Signaling ³	12.07	TNF TLR2 IL17A FOXP3 FAS CD79A
15	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.98	TNF IL17A HLA-DRB1 CD40LG CD4
16	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.89	TNF CD79A CD4 CD209
17	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.83	BCL2 FN1 IL17A TNF
18	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.8	TLR2 IL17A CD4
19	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.78	TNF TLR2 IL17A CD4
20	Innate Lymphoid Cells Differentiation ⁶⁵	11.73	TNF IL17A CD4
21	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.7	HLA-DRB1 CRP CD4
22	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.68	TNF CD4 CD209
23	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway ²²	11.67	TNF CD40LG BCL2
24	Th17 cell differentiation pathway ⁷⁴	11.64	CD4 FOXP3 IL17A
25	Acute viral myocarditis ⁷⁴	11.63	CD40LG CD4 CCR5 BCL2
26	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.62	TNF FOXP3 CD40LG
27	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.59	TNF CRP CD79A CD40LG
28	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.56	TNF TLR2 FOXP3
29	THC Differentiation Pathway ⁶⁴	11.44	TNF HLA-DRB1 CD40LG CD4
30	CTL Mediated Apoptosis ⁶⁴	11.31	FAS HLA-C HLA-DRB1
31	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.23	BCL2 FAS FOXP3 TNF
32	Cytokines and inflammatory response ⁷⁴	11.15	TNF HLA-DRB1 CD4
33	Allograft rejection ⁷⁴	11.14	TNF IL17A HLA-DRB1 HLA-C FOXP3 FAS
34	G-protein signaling_Rap2B regulation pathway ²²	10.96	TNF IL17A FN1 CD40LG BCL2
35	Overview of nanoparticle effects ⁷⁴	10.74	TNF FN1 CRP BCL2

Sources

GO Terms for Syphilis

Cellular components related to Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005887	10.28	CCR5 CD4 CD40LG HLA-C HLA-DRB1 TLR2
2	plasma membrane	GO:0005886	10.28	CCR5 CD4 CD40LG HLA-C HLA-DRB1 TLR2
3	cell surface	GO:0009986	9.96	APOH B2M CCR5 CD209 CD4 CD40LG
4	membrane raft	GO:0045121	9.85	TNF TLR2 FAS CD79A CD4
5	external side of plasma membrane	GO:0009897	9.62	TNF IL17A HLA-DRB1 FAS CD79A CD40LG

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	adaptive immune response	GO:0002250	10.22	CD209 CD4 CD79A HLA-C HLA-DRB1 IL17A
2	inflammatory response	GO:0006954	10.1	TNF TLR2 IL17A FOXP3 CRP CD40LG
3	defense response to Gram-positive bacterium	GO:0050830	10.06	TNF TLR2 IL17A CRP
4	B cell proliferation	GO:0042100	10	CD79A CD40LG BCL2
5	positive regulation of interleukin-12 production	GO:0032735	9.99	TLR2 IL17A CD40LG
6	positive regulation of T cell activation	GO:0050870	9.88	HLA-DRB1 CD4 B2M
7	response to radiation	GO:0009314	9.85	BCL2 FOXP3 TNF
8	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	GO:0032831	9.8	HLA-DRB1 FOXP3
9	antigen processing and presentation	GO:0019882	9.73	HLA-DRB1 HLA-C CD209
10	signaling	GO:0023052	9.62	TNF CD40LG CCR5
11	immune system process	GO:0002376	9.56	TLR2 IL17A HLA-DRB1 HLA-C CD79A CD4
12	regulation of immunoglobulin production	GO:0002637	9.55	CD40LG FOXP3 TNF
13	immune response	GO:0006955	9.55	TNF TLR2 IL17A HLA-DRB1 HLA-C FAS

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.68	TNF TLR2 FOXP3 FN1 FAS CRP
2	peptide antigen binding	GO:0042605	9.63	HLA-DRB1 HLA-C CD209
3	MHC class II protein complex binding	GO:0023026	9.43	HLA-DRB1 CD4 B2M