MCID: SYP003
MIFTS: 56

Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Syphilis

Summaries for Syphilis

MedlinePlus : 43 Syphilis is a sexually transmitted disease caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy. The early stage of syphilis usually causes a single, small, painless sore. Sometimes it causes swelling in nearby lymph nodes. If you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. Many people do not notice symptoms for years. Symptoms can go away and come back. The sores caused by syphilis make it easier to get or give someone HIV during sex. If you are pregnant, syphilis can cause complications, or you could lose your baby. In rare cases, syphilis causes serious health problems and even death. Syphilis is easy to cure with antibiotics if you catch it early. Correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex. Centers for Disease Control and Prevention

MalaCards based summary : Syphilis, also known as syphilitic chancre, is related to late congenital syphilis and tertiary syphilis, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Doxycycline and Emtricitabine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC : 3 You should get tested regularly if you are pregnant, are a man who has sex with men, have HIV infection, and/or have partner(s) who have tested positive for syphilis.

Wikipedia : 76 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 376)
# Related Disease Score Top Affiliating Genes
1 late congenital syphilis 33.7 DDX41 EXTL3
2 tertiary syphilis 33.5 DDX41 EXTL3 MYH9
3 congenital syphilis 33.2 CD40LG CD79A DDX41 EXTL3 MYH9 POLA1
4 primary syphilis 33.1 DDX41 EXTL3 MYH9 POLA1
5 latent syphilis 32.8 DDX41 EXTL3 MYH9 POLA1 TPR
6 secondary syphilis 32.7 CD209 CD40LG CD79A DDX41 EXTL3 POLA1
7 asymptomatic neurosyphilis 32.4 DDX41 EXTL3 MYH9
8 tertiary neurosyphilis 32.3 DDX41 EXTL3 MYH9
9 tabes dorsalis 31.8 DDX41 EXTL3
10 yaws 30.8 EXTL3 TPR
11 sporotrichosis 30.0 CD40LG CD79A
12 connective tissue disease 29.8 APOH CD40LG PPIB
13 meningoencephalitis 29.7 B2M CD40LG CD79A
14 cardiovascular syphilis 12.5
15 early congenital syphilis 12.4
16 gummatous syphilis 12.4
17 bejel 12.1
18 neurosyphilis 12.0
19 syphilitic aseptic meningitis 11.9
20 paroxysmal cold hemoglobinuria 11.5
21 aortic aneurysm, familial thoracic 1 11.4
22 pinta disease 11.3
23 chronic rhinitis 10.9
24 idiopathic hypertrophic pachymeningitis 10.9
25 torch syndrome 10.9
26 progressive locomotor ataxia 10.9
27 syphilitic spinal sclerosis 10.9
28 hepatitis 10.6
29 hepatitis b 10.5
30 chlamydia 10.3
31 hepatitis c 10.3
32 human immunodeficiency virus infectious disease 10.3
33 c1q nephropathy 10.3 CD40LG CD79A
34 immunoglobulin g deficiency 10.3 CD40LG CD79A
35 cryofibrinogenemia 10.3 CD40LG CD79A
36 nephrotic syndrome 10.3
37 heparin-induced thrombocytopenia 10.3 CD40LG CD79A
38 immunoglobulin a deficiency 1 10.3 CD40LG CD79A
39 erythema infectiosum 10.3 APOH CD40LG
40 immunodeficiency-centromeric instability-facial anomalies syndrome 1 10.3 CD40LG CD79A
41 ocular toxoplasmosis 10.3 CD40LG CD79A
42 catastrophic antiphospholipid syndrome 10.2 APOH CD40LG
43 persistent generalized lymphadenopathy 10.2 CD40LG CD79A
44 immunodeficiency with hyper-igm, type 1 10.2 CD40LG CD79A
45 transient pseudohypoaldosteronism 10.2
46 solitary osseous plasmacytoma 10.2 B2M CD79A
47 congenital toxoplasmosis 10.2 CD40LG CD79A
48 chronic pyelonephritis 10.2 B2M CP
49 immunoglobulin alpha deficiency 10.2 CD40LG CD79A
50 intravascular large b-cell lymphoma 10.2 B2M BCL2

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to Syphilis

Symptoms & Phenotypes for Syphilis

UMLS symptoms related to Syphilis:


fever, pruritus, pelvic pain, syphilitic chancre, gummatous inflammation

GenomeRNAi Phenotypes related to Syphilis according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.74 TPR
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.74 CP MYH9 TPR
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.74 BCL2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.74 BCL2 CD79A CP MYH9 TPR
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.74 MYH9
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.74 CP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.74 BCL2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.74 MYH9
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.74 BCL2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.74 MYH9
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.74 MYH9
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.74 CD79A
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.74 CP
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.74 CP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.74 BCL2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.74 TPR
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.74 BCL2
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.74 BCL2
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.74 BCL2
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.74 CP

MGI Mouse Phenotypes related to Syphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.32 APOH B2M BCL2 CD40LG CD79A CP

Drugs & Therapeutics for Syphilis

Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 110)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 564-25-0 54671203
2
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 143491-57-0 60877
3
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 59-46-1 4914
4
Penicillin G Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 61-33-6 5904
5
Tenofovir Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 147127-20-6 464205
6 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Not Applicable
7 Antiparasitic Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
8 Antiviral Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
10 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
11 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
12 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Antimalarials Phase 4,Phase 3,Not Applicable,Early Phase 1
14 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
15 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
16 Penicillin G Benzathine Phase 4,Phase 3,Phase 2,Not Applicable
17 penicillins Phase 4,Phase 3,Phase 2,Not Applicable
18 Penicillin G Procaine Phase 4,Phase 3,Phase 2,Not Applicable
19 Aspartic Acid Phase 4
20 alanine Phase 4
21 N-Methylaspartate Phase 4
22 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4,Phase 3,Phase 2,Not Applicable
23
Guaifenesin Approved, Investigational, Vet_approved Phase 3,Not Applicable 93-14-1 3516
24
Methadone Approved Phase 3,Not Applicable 76-99-3 4095
25
Azithromycin Approved Phase 3,Phase 2 83905-01-5 55185 447043
26
Zidovudine Approved Phase 3 30516-87-1 35370
27
Lamivudine Approved, Investigational Phase 3 134678-17-4 60825
28
Nelfinavir Approved Phase 3 159989-64-7 64143
29
Nevirapine Approved Phase 3 129618-40-2 4463
30
mometasone furoate Approved, Vet_approved Phase 3 83919-23-7
31
leucovorin Approved Phase 3 58-05-9 6006 143
32
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
33
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
34
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
35
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
37
Heroin Illicit, Investigational Phase 3,Not Applicable 561-27-3 5462328
38
Piperaquine Experimental, Investigational Phase 3 4085-31-8 5079497
39
Dihydroartemisinin Experimental, Investigational Phase 3 71939-50-9 6918483
40 Antitussive Agents Phase 3,Not Applicable
41 Analgesics, Opioid Phase 3,Not Applicable
42 Chlorpheniramine, phenylpropanolamine drug combination Phase 3,Not Applicable
43 Analgesics Phase 3,Not Applicable
44 Narcotics Phase 3,Not Applicable
45 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2,Not Applicable
46 Respiratory System Agents Phase 3,Not Applicable
47 Central Nervous System Depressants Phase 3,Not Applicable
48 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
49 Vaccines Phase 3,Phase 2
50
protease inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 164)
# Name Status NCT ID Phase Drugs
1 Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM Unknown status NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
2 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
3 HPTN 073 Black Men Who Have Sex With Men (MSM) Pre-Exposure Prophylaxis (PrEP) Completed NCT01808352 Phase 4 FTC/TDF
4 PRe-Exposure Prophylaxis Acceptability & Readiness Assessments for Toronto gaY, Bisexual and Other Men Who Have Sex With Men-5 Completed NCT02149888 Phase 4 Tenofovir/emtricitabine
5 Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin Recruiting NCT02884115 Phase 4 benzathine penicillin
6 Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection Recruiting NCT03637660 Phase 4 Benzathine Penicillin
7 One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis Recruiting NCT02857959 Phase 4 Benzathine Penicillin G
8 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Recruiting NCT02871505 Phase 4 Benzathine Penicillin G
9 PrEP Implementation for Mothers in Antenatal Care Recruiting NCT03070600 Phase 4 Universal PrEP Counseling;Targeted PrEP Counseling
10 Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia Unknown status NCT02454816 Phase 2, Phase 3
11 (Men Who Have Sex With Men) MSM Community Intervention Trial Unknown status NCT01068015 Phase 3
12 Injecting Drug Use Community Intervention Trial Unknown status NCT01108614 Phase 3
13 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
14 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
15 Male Circumcision for HIV Prevention in Rakai, Uganda Completed NCT00425984 Phase 3
16 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3 Carraguard (PC-515)
17 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
18 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
19 Reducing Sexual Risk Behaviors and Improving Health for People at a Sexually Transmitted Infection Clinic Completed NCT00947271 Phase 3
20 Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Prevention in Men Completed NCT00458393 Phase 3 daily TDF/FTC;Placebo
21 Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV Transmission Completed NCT00099359 Phase 3 Zidovudine;Nevirapine (NVP);Epivir (3TC);Nelfinavir (NFV)
22 MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania Completed NCT00248469 Phase 3
23 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
24 Protecting From Pneumococcus in Early Life (The PROPEL Trial) Recruiting NCT02628886 Phase 3
25 Evaluation of the Long Term Safety, Tolerability and Efficacy of Two Dosing Regimens of Olokizumab (OKZ), in Subjects With Rheumatoid Arthritis (RA) Who Previously Completed 24 Weeks of Blinded Treatment in One of the Core Studies - CREDO 1, 2 or 3. Recruiting NCT03120949 Phase 3 Olokizumab 64 mg SC q4w;Olokizumab 64 mg SC q2w;Methotrexate
26 Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy Recruiting NCT01901094 Phase 3
27 Expanded PrEP Implementation in Communities in NSW Active, not recruiting NCT02870790 Phase 3 TDF/FTC
28 Western Australian Pre-exposure Prophylaxis for HIV Implementation Trial Active, not recruiting NCT03327155 Phase 3 Tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)
29 Mirasol Evaluation of Reduction in Infections Trial Not yet recruiting NCT03737669 Phase 3
30 Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa Not yet recruiting NCT03208179 Phase 3 dihydroartemisinin-piperaquine;sulphadoxine-pyrimethamine;dihydroartemisinin-piperaquine plus azithromycin
31 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3 Azithromycin plus chloroquine;sulfadoxine-pyrimethamine
32 Effectiveness of the Diaphragm for HIV Prevention Withdrawn NCT00121459 Phase 3
33 A Web-based Intervention Study to Reduce High-risk Sexual Behavior by Persons Living With HIV AIDS (PLWH) Completed NCT01198418 Phase 1, Phase 2
34 Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission Completed NCT00213018 Phase 2 Carraguard (PC-515)
35 Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2 Carraguard (PC-515)
36 Behavioral Intervention to Reduce Sexual and Injection Risks Among Female Sex Workers Who Also Inject Drugs in Mexico Completed NCT00840658 Phase 2
37 Lay Health Advisors for Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
38 Safety and Efficacy Study of Human Autologous Hair Follicle Cells to Treat Androgenetic Alopecia Completed NCT01286649 Phase 1, Phase 2
39 Development of a Methamphetamine Early Intervention Completed NCT01174654 Phase 1, Phase 2
40 Comprehensive Triaged HIV Prevention in Tanzania Completed NCT02018978 Phase 2
41 A Tolerability and Efficacy Study of TU-100 For The Treatment of Postoperative Ileus Completed NCT00266461 Phase 2 Daikenchuto Extract Granules (TU-100)
42 Contingency Management for Methamphetamine Abstinence and HIV Post-Exposure Prophylaxis in Men Who Have Sex With Men Completed NCT00856323 Phase 2 Truvada
43 BufferGel and PRO 2000/5: Vaginal Gels to Prevent HIV Infection in Women Completed NCT00074425 Phase 2 BufferGel;PRO 2000/5 Gel;Placebo gel
44 Cefixime for Alternative Syphilis Treatment Recruiting NCT03660488 Phase 2 Cefixime 400 milligram Oral Capsule [Suprax];Benzathine Penicillin G
45 Safer Sex Program for Young African-American Men Recruiting NCT01439503 Phase 2
46 A Novel Regimen to Prevent Malaria and STI in Pregnant Women With HIV Recruiting NCT03431168 Phase 2 Azithromycin/TMPS;Placebo/TMPS
47 A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus Recruiting NCT03617536 Phase 2 CR845 0.25 mg Oral Tablet;CR845 0.5 mg Oral Tablet;CR845 1 mg Oral Tablet;Placebo Oral Tablet
48 Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas Recruiting NCT02503423 Phase 1, Phase 2 ASTX660
49 Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women Not yet recruiting NCT03752112 Phase 1, Phase 2 Cefixime;Benzathine penicillin 2.4 million units
50 Optimizing the Delivery of HIV nPEP Not yet recruiting NCT03259698 Phase 2 nPEP

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: chancre

Genetic Tests for Syphilis

Anatomical Context for Syphilis

MalaCards organs/tissues related to Syphilis:

41
Testes, Skin, Bone, Lymph Node, Liver, Heart, Tongue

Publications for Syphilis

Articles related to Syphilis:

(show top 50) (show all 3597)
# Title Authors Year
1
Natural experiment of syphilis treatment with doxycycline or benzathine penicillin in HIV-infected patients. ( 30102654 )
2019
2
Comparison of three syphilis algorithms in West China. ( 30389458 )
2019
3
A case of secondary syphilis with pulmonary involvement and review of the literature. ( 29621949 )
2018
4
The History of Congenital Syphilis Behind The Inheritance by Edvard Munch. ( 29541782 )
2018
5
Oral findings in secondary syphilis. ( 29476680 )
2018
6
Use of National Syphilis Surveillance Data to Develop a Congenital Syphilis Prevention Cascade and Estimate the Number of Potential Congenital Syphilis Cases Averted. ( 29543623 )
2018
7
Bio-behavioral survey of syphilis in homeless men in Central Brazil: a cross-sectional study. ( 29952395 )
2018
8
Secondary syphilis: an atypical presentation complicated by a false negative rapid plasma reagin test. ( 29894545 )
2018
9
Secondary syphilis: lest we forget it. ( 29545459 )
2018
10
A brief recent history of the epidemiology of congenital syphilis in the United Kingdom. ( 29862901 )
2018
11
Cross-sectional study of Treponema pallidum PCR in diagnosis of primary and secondary syphilis. ( 29090453 )
2018
12
A Case of Congenital Syphilis Presenting with Unusual Skin Eruptions. ( 29770234 )
2018
13
Rare Case of Four Osseous Lesions of the Skull in a Patient with Secondary Syphilis. ( 29854502 )
2018
14
Secondary Syphilis with Tonsillar and Cervical Lymphadenopathy and a Pulmonary Lesion Mimicking Malignant Lymphoma. ( 29502129 )
2018
15
Pathways to Congenital Syphilis Prevention: A Rapid Qualitative Assessment of Barriers, and the Public Health Response, in Caddo Parish, Louisiana. ( 29465658 )
2018
16
Annular and arcuate syphilis: an uncommon presentation of disseminated secondary syphilis. ( 29906011 )
2018
17
An Emergency Department Presentation of Secondary Syphilis. ( 29547908 )
2018
18
Bejel in Cuba: molecular identification of Treponema pallidum subsp. endemicum in patients diagnosed with venereal syphilis. ( 29454847 )
2018
19
A rare presentation of congenital syphilis: Pemphigus syphiliticus in a newborn infant with extensive desquamation of the extremities. ( 29314211 )
2018
20
Social networks as drivers of syphilis and HIV infection among young men who have sex with men. ( 29440465 )
2018
21
Congenital syphilis. ( 29627075 )
2018
22
A Comparison of syphilis partner notification outcomes by reported use of internet-based apps to meet sex partners in North Carolina, 2013-2016. ( 29944644 )
2018
23
Fight fire with fire: Innovations to address syphilis among men who have sex with men. ( 29965945 )
2018
24
Primary syphilis occurring as an extensive ulceration on the palatal gingival mucosa diagnosed by immunohistochemical staining. ( 29730886 )
2018
25
Primary and Secondary Syphilis as Chancre of the Mouth with Rash. ( 29033418 )
2018
26
Prevention of Congenital Syphilis Through Antenatal Screenings in Lusaka, Zambia: A Systematic Review. ( 29560291 )
2018
27
Gastric syphilis: The great imitator in the stomach. ( 29942761 )
2018
28
Serological response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin. ( 29394361 )
2018
29
Image Gallery: A case of malignant syphilis in an HIV-infected patient mimicking fungal infection. ( 29357605 )
2018
30
Challenges of RPR interpretation in syphilis screening in Uganda: variability in non-treponemal results between different laboratories. ( 29944643 )
2018
31
Dactylitis as the presenting manifestation of congenital syphilis in an infant. ( 29787466 )
2018
32
Sixth child dies from congenital syphilis in northern Australia. ( 29555652 )
2018
33
Rapid progression to gummatous tertiary syphilis in a patient with HIV. ( 29882582 )
2018
34
Secondary Syphilis Mimicking Giant Cell Arteritis. ( 29561471 )
2018
35
Repeat Syphilis Is More Likely to Be Asymptomatic in HIV-Infected Individuals: A Retrospective Cohort Analysis With Important Implications for Screening. ( 29977956 )
2018
36
Reactor Grids for Prioritizing Syphilis Investigations: Are Primary Syphilis Cases Being Missed? ( 29528995 )
2018
37
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series. ( 29972419 )
2018
38
HIV and syphilis epidemic among MSM and non-MSM aged 50 and above in Shanghai, China: A yearly cross-sectional study, 2008-2014. ( 29419357 )
2018
39
Syphilis in the Setting of Anti-tumor Necrosis Factor Alpha Therapy. ( 29398464 )
2018
40
Traditional and Web-Based Technologies to Improve Partner Notification Following Syphilis Diagnosis Among Men Who Have Sex With Men in Lima, Peru: Pilot Randomized Controlled Trial. ( 29970355 )
2018
41
Long-Term <i>In Vitro</i> Culture of the Syphilis Spirochete <i>Treponema pallidum</i> subsp. <i>pallidum</i>. ( 29946052 )
2018
42
High seroprevalence of syphilis among HIV-infected patients and predictors associated. ( 29943623 )
2018
43
Secondary Syphilis Without Any History of Primary Infection. ( 29366456 )
2018
44
Prevalence estimates of HIV, syphilis, hepatitis B and C among female sex workers (FSW) in Brazil, 2016. ( 29912817 )
2018
45
Syphilis in Children. ( 29406973 )
2018
46
Analysis of cases of gestational and congenital syphilis between 2008 and 2010 in Fortaleza, State of CearA!, Brazil. ( 29412414 )
2018
47
Julio Tello as a medical anthropologist: assessing the antiquity of syphilis in ancient Peru. ( 29898134 )
2018
48
Presence of dental signs of congenital syphilis in pre-modern specimens. ( 29102860 )
2018
49
Fulminant hepatitis in a patient with secondary syphilis. ( 29979145 )
2018
50
Infectious and congenital syphilis in Canada, 2010-2015. ( 29770098 )
2018

Variations for Syphilis

Copy number variations for Syphilis from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 111152 17 35097918 35138441 Copy number ERBB2 Syphilis

Expression for Syphilis

Search GEO for disease gene expression data for Syphilis.

Pathways for Syphilis

Pathways related to Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.92 B2M BCL2 CD209 CD40LG CD79A DDX41
2 11.26 B2M CD40LG HLA-C
3 10.55 B2M HLA-C

GO Terms for Syphilis

Cellular components related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 B2M CD209 CD40LG CD79A
2 cell surface GO:0009986 9.35 APOH B2M CD209 CD40LG HLA-C
3 MHC class I protein complex GO:0042612 8.62 B2M HLA-C

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell differentiation in thymus GO:0033077 9.46 B2M BCL2
2 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.43 B2M HLA-C
3 leukocyte cell-cell adhesion GO:0007159 9.4 CD209 CD40LG
4 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.37 B2M HLA-C
5 B cell differentiation GO:0030183 9.33 BCL2 CD40LG CD79A
6 positive regulation of T cell mediated cytotoxicity GO:0001916 9.32 B2M HLA-C
7 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.26 B2M HLA-C
8 negative regulation of myeloid cell apoptotic process GO:0033033 8.96 APOH BCL2
9 B cell proliferation GO:0042100 8.8 BCL2 CD40LG CD79A

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.8 APOH B2M BCL2 CD209 CD40LG CD79A
2 protein membrane anchor GO:0043495 8.62 MYH9 TPR

Sources for Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
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