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MCID: SYP003
MIFTS: 51

Syphilis

Categories: Infectious diseases, Neuronal diseases, Bone diseases, Fetal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Syphilis

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MalaCards integrated aliases for Syphilis:

Name: Syphilis 12 76 55 43 3 44 15 73
Syphilitic Chancre 12

Classifications:

MalaCards categories:
Global: Infectious diseases Fetal diseases Rare diseases
Anatomical: Neuronal diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:4166
ICD10 33 A51.0 A53.9
MeSH 44 D013587
SNOMED-CT 68 266127002 58433006
Sources

Summaries for Syphilis

About this section
MedlinePlus : 43 Syphilis is a sexually transmitted disease caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy. The early stage of syphilis usually causes a single, small, painless sore. Sometimes it causes swelling in nearby lymph nodes. If you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. Many people do not notice symptoms for years. Symptoms can go away and come back. The sores caused by syphilis make it easier to get or give someone HIV during sex. If you are pregnant, syphilis can cause complications, or you could lose your baby. In rare cases, syphilis causes serious health problems and even death. Syphilis is easy to cure with antibiotics if you catch it early. Correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex. Centers for Disease Control and Prevention

MalaCards based summary : Syphilis, also known as syphilitic chancre, is related to early congenital syphilis and cardiovascular syphilis, and has symptoms including syphilitic chancre, fever and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H). The drugs Penicillin G and Procaine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and heart, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC : 3 Information about US Syphilis Increase

Wikipedia : 76 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

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Related Diseases for Syphilis

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Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 378)
# Related Disease Score Top Affiliating Genes
1 early congenital syphilis 34.2 CD40LG MYH9
2 cardiovascular syphilis 34.0 CD40LG DDX41
3 late congenital syphilis 33.6 DDX41 EXTL3
4 primary syphilis 32.7 CD40LG EXTL3 MYH9 POLA1
5 tertiary syphilis 32.2 CD40LG DDX41 EXTL3 MYH9
6 tabes dorsalis 31.3 CD79A DDX41 EXTL3
7 congenital syphilis 31.1 CD40LG CD79A DDX41 EXTL3 MYH9 POLA1
8 yaws 31.1 EXTL3 TPR
9 secondary syphilis 30.9 CD40LG CD79A DDX41 EXTL3 POLA1 TPR
10 antiphospholipid syndrome 30.8 APOH CD40LG CD79A
11 vasculitis 30.8 APOH CD40LG CD79A
12 sporotrichosis 30.8 CD40LG CD79A
13 chorioretinitis 30.7 CD40LG CD79A EXTL3
14 asymptomatic neurosyphilis 30.7 CD40LG CD79A DDX41 EXTL3 MYH9
15 acquired immunodeficiency syndrome 30.7 B2M CD40LG CD79A
16 meningovascular neurosyphilis 30.7 CD40LG CD79A
17 tertiary neurosyphilis 30.6 CD40LG CD79A DDX41 EXTL3 MYH9
18 latent syphilis 30.3 CD40LG DDX41 EXTL3 MYH9 POLA1 TPR
19 syphilitic meningitis 30.3 CD40LG EXTL3
20 urethritis 30.3 CD40LG CD79A EXTL3
21 trichomoniasis 30.2 CD79A EXTL3
22 purpura 30.2 APOH CD40LG CD79A
23 meningoencephalitis 30.2 B2M CD40LG CD79A
24 rheumatic disease 30.1 APOH CD40LG HLA-DRB1
25 discoid lupus erythematosus 30.0 APOH HLA-DRB1
26 early yaws 29.9 CD40LG CD79A EXTL3
27 focal chorioretinitis 29.6 CD40LG DDX41
28 gummatous syphilis 12.2
29 bejel 12.0
30 neurosyphilis 11.9
31 syphilitic aseptic meningitis 11.8
32 aortic aneurysm, familial thoracic 1 11.3
33 paroxysmal cold hemoglobinuria 11.3
34 selective igg deficiency disease 11.0 CD40LG CD79A
35 c1q nephropathy 11.0 CD40LG CD79A
36 alpha chain disease 11.0 CD40LG CD79A
37 brill-zinsser disease 11.0 CD40LG CD79A
38 exudative glomerulonephritis 11.0 CD40LG CD79A
39 cork-handlers' disease 11.0 CD40LG CD79A
40 salpingo-oophoritis 11.0 CD40LG CD79A
41 ventilation pneumonitis 11.0 CD40LG CD79A
42 chronic interstitial cystitis 11.0 CD40LG CD79A
43 axillary adenitis 11.0 CD40LG CD79A
44 cryofibrinogenemia 11.0 CD40LG CD79A
45 borderline leprosy 11.0 APOH CD40LG
46 trichostrongyloidiasis 10.9 CD40LG CD79A
47 subacute bacterial endocarditis 10.9 CD40LG CD79A
48 heterophyiasis 10.9 CD40LG CD79A
49 immunoglobulin g deficiency 10.9 CD40LG CD79A
50 viral exanthem 10.9 APOH CD40LG

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to Syphilis
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Symptoms & Phenotypes for Syphilis

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UMLS symptoms related to Syphilis:


syphilitic chancre, fever, pelvic pain, pruritus, gummatous inflammation

GenomeRNAi Phenotypes related to Syphilis according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.68 TPR
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.68 BCL2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.68 BCL2 CD79A CP MYH9 TPR
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.68 MYH9
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.68 CP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.68 BCL2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.68 MYH9
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.68 BCL2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.68 MYH9
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.68 MYH9
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.68 CD79A
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.68 CP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.68 CP
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.68 BCL2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.68 TPR
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.68 BCL2
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.68 BCL2
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.68 BCL2
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.68 CP

MGI Mouse Phenotypes related to Syphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.32 B2M BCL2 CD40LG CD79A CP EXTL3
Sources

Drugs & Therapeutics for Syphilis

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Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Phase 4,Phase 3,Not Applicable 61-33-6 5904
2
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 59-46-1 4914
3
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 143491-57-0 60877
4
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 564-25-0 54671203
5 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
7 Penicillin G Benzathine Phase 4,Phase 3,Not Applicable
8 Penicillin G Procaine Phase 4,Phase 3,Not Applicable
9 penicillins Phase 4,Phase 3,Not Applicable
10 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Not Applicable
11 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Antiviral Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 N-Methylaspartate Phase 4
14 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
15 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
16
Tenofovir Phase 4,Phase 3,Phase 2,Not Applicable 147127-20-6 464205
17 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4,Phase 3,Phase 2,Not Applicable
18 Antimalarials Phase 4,Phase 3,Not Applicable,Early Phase 1
19 Antiparasitic Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
20 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
21 alanine Nutraceutical Phase 4
22 Aspartic Acid Nutraceutical Phase 4
23
Guaifenesin Approved, Investigational, Vet_approved Phase 3,Not Applicable 93-14-1 3516
24
Heroin Approved, Illicit, Investigational Phase 3,Not Applicable 561-27-3 5462328
25
Methadone Approved Phase 3,Not Applicable 76-99-3 4095
26
Azithromycin Approved Phase 3 83905-01-5 55185 447043
27
Lamivudine Approved, Investigational Phase 3 134678-17-4 60825
28
Nelfinavir Approved Phase 3 159989-64-7 64143
29
Nevirapine Approved Phase 3 129618-40-2 4463
30
Zidovudine Approved Phase 3 30516-87-1 35370
31
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
32
Dihydroartemisinin Approved, Investigational Phase 3 71939-50-9 6918483
33
Piperaquine Approved, Investigational Phase 3 4085-31-8 5079497
34
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
35
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
36
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
39 Analgesics Phase 3,Not Applicable
40 Analgesics, Opioid Phase 3,Not Applicable
41 Antitussive Agents Phase 3,Not Applicable
42 Central Nervous System Depressants Phase 3,Not Applicable
43 Chlorpheniramine, phenylpropanolamine drug combination Phase 3,Not Applicable
44 Narcotics Phase 3,Not Applicable
45 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2,Not Applicable
46 Respiratory System Agents Phase 3,Not Applicable
47 Vaccines Phase 3,Phase 2
48 Antimetabolites Phase 3
49 Cytochrome P-450 CYP3A Inducers Phase 3
50 HIV Protease Inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 150)
# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 HPTN 073 Black Men Who Have Sex With Men (MSM) Pre-Exposure Prophylaxis (PrEP) Completed NCT01808352 Phase 4 FTC/TDF
3 PRe-Exposure Prophylaxis Acceptability & Readiness Assessments for Toronto gaY, Bisexual and Other Men Who Have Sex With Men-5 Completed NCT02149888 Phase 4 Tenofovir/emtricitabine
4 Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin Recruiting NCT02884115 Phase 4 benzathine penicillin
5 One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis Recruiting NCT02857959 Phase 4 Benzathine Penicillin G
6 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Recruiting NCT02871505 Phase 4 Benzathine Penicillin G
7 PrEP Implementation for Mothers in Antenatal Care Recruiting NCT03070600 Phase 4 Universal PrEP Counseling;Targeted PrEP Counseling
8 Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM Not yet recruiting NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
9 Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia Unknown status NCT02454816 Phase 2, Phase 3
10 (Men Who Have Sex With Men) MSM Community Intervention Trial Unknown status NCT01068015 Phase 3
11 Injecting Drug Use Community Intervention Trial Unknown status NCT01108614 Phase 3
12 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
13 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
14 Male Circumcision for HIV Prevention in Rakai, Uganda Completed NCT00425984 Phase 3
15 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
16 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3 Carraguard (PC-515)
17 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
18 Reducing Sexual Risk Behaviors and Improving Health for People at a Sexually Transmitted Infection Clinic Completed NCT00947271 Phase 3
19 Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Prevention in Men Completed NCT00458393 Phase 3 daily TDF/FTC;Placebo
20 Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV Transmission Completed NCT00099359 Phase 3 Zidovudine;Nevirapine (NVP);Epivir (3TC);Nelfinavir (NFV)
21 MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania Completed NCT00248469 Phase 3
22 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
23 Western Australian Pre-exposure Prophylaxis for HIV Implementation Trial Recruiting NCT03327155 Phase 3 Tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)
24 Protecting From Pneumococcus in Early Life (The PROPEL Trial) Recruiting NCT02628886 Phase 3
25 Evaluation of the Long Term Safety, Tolerability and Efficacy of Two Dosing Regimens of Olokizumab (OKZ), in Subjects With Rheumatoid Arthritis (RA) Who Previously Completed 24 Weeks of Blinded Treatment in One of the Core Studies - CREDO 1, 2 or 3. Recruiting NCT03120949 Phase 3 Olokizumab 64 mg SC q4w;Olokizumab 64 mg SC q2w;Methotrexate
26 Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy Recruiting NCT01901094 Phase 3
27 Expanded PrEP Implementation in Communities in NSW Active, not recruiting NCT02870790 Phase 3 TDF/FTC
28 Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa Not yet recruiting NCT03208179 Phase 3 dihydroartemisinin-piperaquine;sulphadoxine-pyrimethamine;dihydroartemisinin-piperaquine plus azithromycin
29 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3 Azithromycin plus chloroquine;sulfadoxine-pyrimethamine
30 Effectiveness of the Diaphragm for HIV Prevention Withdrawn NCT00121459 Phase 3
31 A Web-based Intervention Study to Reduce High-risk Sexual Behavior by Persons Living With HIV AIDS (PLWH) Completed NCT01198418 Phase 1, Phase 2
32 Safety, Acceptability and Preliminary Effectiveness of Carraguardâ„¢ (PC-515) in Preventing HIV/STI Transmission Completed NCT00213018 Phase 2 Carraguard (PC-515)
33 Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2 Carraguard (PC-515)
34 Behavioral Intervention to Reduce Sexual and Injection Risks Among Female Sex Workers Who Also Inject Drugs in Mexico Completed NCT00840658 Phase 2
35 Lay Health Advisors for Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
36 Safety and Efficacy Study of Human Autologous Hair Follicle Cells to Treat Androgenetic Alopecia Completed NCT01286649 Phase 1, Phase 2
37 Development of a Methamphetamine Early Intervention Completed NCT01174654 Phase 1, Phase 2
38 Comprehensive Triaged HIV Prevention in Tanzania Completed NCT02018978 Phase 2
39 A Tolerability and Efficacy Study of TU-100 For The Treatment of Postoperative Ileus Completed NCT00266461 Phase 2 Daikenchuto Extract Granules (TU-100)
40 Contingency Management for Methamphetamine Abstinence and HIV Post-Exposure Prophylaxis in Men Who Have Sex With Men Completed NCT00856323 Phase 2 Truvada
41 BufferGel and PRO 2000/5: Vaginal Gels to Prevent HIV Infection in Women Completed NCT00074425 Phase 2 BufferGel;PRO 2000/5 Gel;Placebo gel
42 Safer Sex Program for Young African-American Men Recruiting NCT01439503 Phase 2
43 A Novel Regimen to Prevent Malaria and STI in Pregnant Women With HIV Recruiting NCT03431168 Phase 2 Azithromycin/TMPS;Placebo/TMPS
44 Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas Recruiting NCT02503423 Phase 1, Phase 2 ASTX660
45 Optimizing the Delivery of HIV nPEP Not yet recruiting NCT03259698 Phase 2 nPEP
46 Development of Immune Globulin Treatment for Avian Flu Terminated NCT00383071 Phase 2
47 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
48 Computer-Assisted Tailored Cue-card Health [CATCH] Study Completed NCT01170741 Phase 1
49 Fecal Microbiota Transplantation in Pediatric Patients Completed NCT02108821 Phase 1
50 Safety and Acceptability of Carraguardâ„¢ Among HIV-negative Couples in Thailand Completed NCT00213057 Phase 1 Carraguard (PC-515)

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: syphilis

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Genetic Tests for Syphilis

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Anatomical Context for Syphilis

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MalaCards organs/tissues related to Syphilis:

41
Testes, Skin, Heart, Lymph Node, Bone, Liver, Tonsil
Sources

Publications for Syphilis

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Articles related to Syphilis:

(show top 50) (show all 2449)
# Title Authors Year
1
A case of secondary syphilis with pulmonary involvement and review of the literature. ( 29621949 )
2018
2
The History of Congenital Syphilis Behind The Inheritance by Edvard Munch. ( 29541782 )
2018
3
Oral findings in secondary syphilis. ( 29476680 )
2018
4
Use of National Syphilis Surveillance Data to Develop a Congenital Syphilis Prevention Cascade and Estimate the Number of Potential Congenital Syphilis Cases Averted. ( 29543623 )
2018
5
Bio-behavioral survey of syphilis in homeless men in Central Brazil: a cross-sectional study. ( 29952395 )
2018
6
Secondary syphilis: an atypical presentation complicated by a false negative rapid plasma reagin test. ( 29894545 )
2018
7
Secondary syphilis: lest we forget it. ( 29545459 )
2018
8
A brief recent history of the epidemiology of congenital syphilis in the United Kingdom. ( 29862901 )
2018
9
Cross-sectional study of Treponema pallidum PCR in diagnosis of primary and secondary syphilis. ( 29090453 )
2018
10
A Case of Congenital Syphilis Presenting with Unusual Skin Eruptions. ( 29770234 )
2018
11
Rare Case of Four Osseous Lesions of the Skull in a Patient with Secondary Syphilis. ( 29854502 )
2018
12
Secondary Syphilis with Tonsillar and Cervical Lymphadenopathy and a Pulmonary Lesion Mimicking Malignant Lymphoma. ( 29502129 )
2018
13
Pathways to Congenital Syphilis Prevention: A Rapid Qualitative Assessment of Barriers, and the Public Health Response, in Caddo Parish, Louisiana. ( 29465658 )
2018
14
Annular and arcuate syphilis: an uncommon presentation of disseminated secondary syphilis. ( 29906011 )
2018
15
An Emergency Department Presentation of Secondary Syphilis. ( 29547908 )
2018
16
Bejel in Cuba: molecular identification of Treponema pallidum subsp. endemicum in patients diagnosed with venereal syphilis. ( 29454847 )
2018
17
A rare presentation of congenital syphilis: Pemphigus syphiliticus in a newborn infant with extensive desquamation of the extremities. ( 29314211 )
2018
18
Social networks as drivers of syphilis and HIV infection among young men who have sex with men. ( 29440465 )
2018
19
Congenital syphilis. ( 29627075 )
2018
20
A Comparison of syphilis partner notification outcomes by reported use of internet-based apps to meet sex partners in North Carolina, 2013-2016. ( 29944644 )
2018
21
Fight fire with fire: Innovations to address syphilis among men who have sex with men. ( 29965945 )
2018
22
Primary syphilis occurring as an extensive ulceration on the palatal gingival mucosa diagnosed by immunohistochemical staining. ( 29730886 )
2018
23
Primary and Secondary Syphilis as Chancre of the Mouth with Rash. ( 29033418 )
2018
24
Prevention of Congenital Syphilis Through Antenatal Screenings in Lusaka, Zambia: A Systematic Review. ( 29560291 )
2018
25
Gastric syphilis: The great imitator in the stomach. ( 29942761 )
2018
26
Serological response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin. ( 29394361 )
2018
27
Image Gallery: A case of malignant syphilis in an HIV-infected patient mimicking fungal infection. ( 29357605 )
2018
28
Challenges of RPR interpretation in syphilis screening in Uganda: variability in non-treponemal results between different laboratories. ( 29944643 )
2018
29
Dactylitis as the presenting manifestation of congenital syphilis in an infant. ( 29787466 )
2018
30
Sixth child dies from congenital syphilis in northern Australia. ( 29555652 )
2018
31
Rapid progression to gummatous tertiary syphilis in a patient with HIV. ( 29882582 )
2018
32
Secondary Syphilis Mimicking Giant Cell Arteritis. ( 29561471 )
2018
33
Repeat Syphilis Is More Likely to Be Asymptomatic in HIV-Infected Individuals: A Retrospective Cohort Analysis With Important Implications for Screening. ( 29977956 )
2018
34
Reactor Grids for Prioritizing Syphilis Investigations: Are Primary Syphilis Cases Being Missed? ( 29528995 )
2018
35
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series. ( 29972419 )
2018
36
HIV and syphilis epidemic among MSM and non-MSM aged 50 and above in Shanghai, China: A yearly cross-sectional study, 2008-2014. ( 29419357 )
2018
37
Syphilis in the Setting of Anti-tumor Necrosis Factor Alpha Therapy. ( 29398464 )
2018
38
Traditional and Web-Based Technologies to Improve Partner Notification Following Syphilis Diagnosis Among Men Who Have Sex With Men in Lima, Peru: Pilot Randomized Controlled Trial. ( 29970355 )
2018
39
Long-Term <i>In Vitro</i> Culture of the Syphilis Spirochete <i>Treponema pallidum</i> subsp. <i>pallidum</i>. ( 29946052 )
2018
40
High seroprevalence of syphilis among HIV-infected patients and predictors associated. ( 29943623 )
2018
41
Secondary Syphilis Without Any History of Primary Infection. ( 29366456 )
2018
42
Prevalence estimates of HIV, syphilis, hepatitis B and C among female sex workers (FSW) in Brazil, 2016. ( 29912817 )
2018
43
Syphilis in Children. ( 29406973 )
2018
44
Analysis of cases of gestational and congenital syphilis between 2008 and 2010 in Fortaleza, State of CearA!, Brazil. ( 29412414 )
2018
45
Julio Tello as a medical anthropologist: assessing the antiquity of syphilis in ancient Peru. ( 29898134 )
2018
46
Presence of dental signs of congenital syphilis in pre-modern specimens. ( 29102860 )
2018
47
Fulminant hepatitis in a patient with secondary syphilis. ( 29979145 )
2018
48
Infectious and congenital syphilis in Canada, 2010-2015. ( 29770098 )
2018
49
High prevalence of syphilis in parturient women and congenital syphilis cases in public maternities in Salvador-Bahia, Brazil. ( 29802689 )
2018
50
Congenital Syphilis Prevention: Strategies, Evidence, and Future Directions. ( 29624562 )
2018
Sources

Variations for Syphilis

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Copy number variations for Syphilis from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 111152 17 35097918 35138441 Copy number ERBB2 Syphilis
Sources

Expression for Syphilis

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Search GEO for disease gene expression data for Syphilis.
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Pathways for Syphilis

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GO Terms for Syphilis

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Cellular components related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 B2M CD40LG CD79A HLA-DRB1

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.33 BCL2 CD40LG CD79A
2 negative regulation of myeloid cell apoptotic process GO:0033033 8.96 APOH BCL2
3 B cell proliferation GO:0042100 8.8 BCL2 CD40LG CD79A

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein membrane anchor GO:0043495 8.62 MYH9 TPR
Sources

Sources for Syphilis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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