MCID: SYP003
MIFTS: 59

Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Syphilis

Summaries for Syphilis

MedlinePlus : 43 Syphilis is a sexually transmitted disease caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy. The early stage of syphilis usually causes a single, small, painless sore. Sometimes it causes swelling in nearby lymph nodes. If you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. Many people do not notice symptoms for years. Symptoms can go away and come back. The sores caused by syphilis make it easier to get or give someone HIV during sex. If you are pregnant, syphilis can cause complications, or you could lose your baby. In rare cases, syphilis causes serious health problems and even death. Syphilis is easy to cure with antibiotics if you catch it early. Correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex. Centers for Disease Control and Prevention

MalaCards based summary : Syphilis, also known as chancre, is related to tertiary syphilis and primary syphilis, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Spironolactone and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone, and related phenotypes are cellular and homeostasis/metabolism

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC : 3 Syphilis is a sexually transmitted infection that can cause serious health problems if it is not treated. Syphilis is divided into stages (primary, secondary, latent, and tertiary). There are different signs and symptoms associated with each stage.

Wikipedia : 75 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 793)
# Related Disease Score Top Affiliating Genes
1 tertiary syphilis 34.4 MYH9 DDX41
2 primary syphilis 33.6 POLA1 MYH9 DDX41
3 congenital syphilis 33.3 POLA1 MYH9 DDX41 CD79A CD40LG
4 asymptomatic neurosyphilis 33.3 MYH9 DDX41
5 latent syphilis 32.5 TPR POLA1 MYH9 DDX41
6 secondary syphilis 31.6 TPR POLA1 FN1 DDX41 CD79A CD40LG
7 autoimmune disease 30.6 FAS CD40LG APOH
8 sporotrichosis 30.6 CD79A CD40LG
9 meningoencephalitis 30.6 CD79A CD40LG B2M
10 congenital rubella 30.3 CD40LG CAT
11 chronic pyelonephritis 30.0 CP B2M
12 lymphoma, non-hodgkin, familial 29.4 FAS CD79A BCL2 B2M
13 common variable immunodeficiency 29.4 FAS CD79A CD40LG
14 cardiovascular syphilis 12.7
15 late congenital syphilis 12.7
16 early congenital syphilis 12.7
17 gummatous syphilis 12.5
18 bejel 12.3
19 neurosyphilis 12.2
20 syphilitic aseptic meningitis 12.1
21 tertiary neurosyphilis 12.1
22 paroxysmal cold hemoglobinuria 11.7
23 aortic aneurysm, familial thoracic 1 11.6
24 tabes dorsalis 11.5
25 pinta disease 11.5
26 mikulicz disease 11.1
27 chronic rhinitis 11.1
28 idiopathic hypertrophic pachymeningitis 11.1
29 torch syndrome 11.1
30 progressive locomotor ataxia 11.1
31 syphilitic spinal sclerosis 11.1
32 transient pseudohypoaldosteronism 10.9
33 exanthem 10.7
34 c1q nephropathy 10.7 CD79A CD40LG
35 immunoglobulin g deficiency 10.7 CD79A CD40LG
36 immune deficiency disease 10.6
37 heparin-induced thrombocytopenia 10.6 CD79A CD40LG
38 erythema infectiosum 10.6 CD40LG APOH
39 immunoglobulin a deficiency 1 10.6 CD79A CD40LG
40 uveitis 10.6
41 chlamydia 10.6
42 ocular toxoplasmosis 10.6 CD79A CD40LG
43 yaws 10.6
44 immunodeficiency-centromeric instability-facial anomalies syndrome 1 10.6 CD79A CD40LG
45 catastrophic antiphospholipid syndrome 10.6 CD40LG APOH
46 persistent generalized lymphadenopathy 10.6 CD79A CD40LG
47 intravascular large b-cell lymphoma 10.5 BCL2 B2M
48 leprosy 3 10.5
49 hansen's disease 10.5
50 immunodeficiency with hyper-igm, type 1 10.5 CD79A CD40LG

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to Syphilis

Symptoms & Phenotypes for Syphilis

UMLS symptoms related to Syphilis:


fever, pruritus, pelvic pain, syphilitic chancre, gummatous inflammation

MGI Mouse Phenotypes related to Syphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 B2M BCL2 CAT CD4 CD40LG CD79A
2 homeostasis/metabolism MP:0005376 10.06 APOH B2M BCL2 CAT CD4 CD40LG
3 hematopoietic system MP:0005397 10.02 B2M BCL2 CD4 CD40LG CD79A CP
4 immune system MP:0005387 9.91 B2M BCL2 CD4 CD40LG CD79A CP
5 mortality/aging MP:0010768 9.9 APOH B2M BCL2 CAT CD4 CD40LG
6 neoplasm MP:0002006 9.43 B2M BCL2 CAT CD79A FAS FN1
7 nervous system MP:0003631 9.28 B2M BCL2 CD4 CD40LG CD79A CP

Drugs & Therapeutics for Syphilis

Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
3
Polyestradiol phosphate Approved Phase 4 28014-46-2
4
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
5
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
6
Azithromycin Approved Phase 4 83905-01-5 447043 55185
7
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
8
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
9
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
10 Hormone Antagonists Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Androgen Antagonists Phase 4
13 Estradiol 3-benzoate Phase 4
14 Estradiol 17 beta-cypionate Phase 4
15 penicillins Phase 4
16 Anti-Bacterial Agents Phase 4
17 Anti-Infective Agents Phase 4
18 Penicillin G Procaine Phase 4
19 Penicillin G Benzathine Phase 4
20 Nucleic Acid Synthesis Inhibitors Phase 4
21 Reverse Transcriptase Inhibitors Phase 4
22 Anti-HIV Agents Phase 4
23 Antiviral Agents Phase 4
24 Antimalarials Phase 4
25 Antiparasitic Agents Phase 4
26 Antiprotozoal Agents Phase 4
27
Methadone Approved, Illicit Phase 3 76-99-3 4095
28
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
29
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
30
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
31
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
32
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
33
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
34
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
35
Nitrofurantoin Approved, Vet_approved Phase 3 67-20-9 5353830
36
carbamide peroxide Approved Phase 3 124-43-6
37
Acyclovir Approved Phase 3 59277-89-3 2022
38
mometasone furoate Approved, Investigational, Vet_approved Phase 3 83919-23-7
39
acetic acid Approved Phase 3 64-19-7 176
40
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
41 Antibiotics, Antitubercular Phase 3
42 Narcotics Phase 3
43 Respiratory System Agents Phase 3
44 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
45 Analgesics, Opioid Phase 3
46 Antitussive Agents Phase 3
47
Heroin Phase 3 5462328
48 Autonomic Agents Phase 3
49 Gastrointestinal Agents Phase 3
50 Antiemetics Phase 3

Interventional clinical trials:

(show top 50) (show all 205)
# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage in HIV Co-Infected Patients Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Gender-Affirmative Medical Care to Improve HIV Treatment Cascade Among Transgender Women Completed NCT03757117 Phase 4 Feminizing hormone therapy
3 Doctor of Medicine Recruiting NCT02857959 Phase 4 Benzathine Penicillin G
4 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Recruiting NCT02871505 Phase 4 Benzathine Penicillin G
5 A Phase 4 Comparative Trial of Benzathine Penicillin G 2.4 Million Units Administered as a Single Dose Versus Three Successive Weekly Doses for Treatment of Early Syphilis in Subjects With or Without HIV Infection Recruiting NCT03637660 Phase 4 Benzathine Penicillin
6 Randomized, Clinical Trial to Compare the Serological Response Rates of Serofast Early Syphilis Cases Retreated With Three Doses Benzathine Penicillin and Absence of Any Retreatment Recruiting NCT02884115 Phase 4 benzathine penicillin
7 Hepatitis B Virus Vaccination in HIV-positive Patients and Individuals at High Risk for HIV Infection: an Open-label Randomized Clinical Trial Recruiting NCT03854630 Phase 4 Engerix-B
8 Delivering PrEP in Pregnancy Recruiting NCT03070600 Phase 4 Universal PrEP Counseling;Targeted PrEP Counseling
9 Use of Tenofovir/Emtricitabine With Immediate or Deferred Doxycycline 100mg PO Daily for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative Men Who Have Sex With Men: a Pilot Study of Dual Daily HIV and Syphilis PrEP. (The DuDHS Trial). Active, not recruiting NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
10 Defining the Best Distribution Strategy of Azithromycin for Yaws Eradication (The Yaws 3 Trial) Active, not recruiting NCT03490123 Phase 4 R1-Total community treatment with azithromycin;R2-Total community treatment with azithromycin;R3-Total community treatment with azithromycin;R2-Total targeted treatment with azithromycin;R3-Total targeted treatment with azithromycin
11 A Randomized, Placebo-controlled Trial of Oral Doxycycline for the Prevention of Syphilis in HIV-positive Men Who Have Sex With Men (MSM) Not yet recruiting NCT02864550 Phase 4 Doxycycline
12 Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men Not yet recruiting NCT03980223 Phase 4 Doxycycline Hyclate Delayed-Release 200 mg
13 PrEP and dPEP: Doxycycline Post-exposure Prophylaxis for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV Pre-exposure Prophylaxis Not yet recruiting NCT04050540 Phase 4 Doxycycline
14 Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in COLOMBIA Unknown status NCT02454816 Phase 2, Phase 3
15 A Randomized Community Intervention Trial on Reducing HIV Infection Among Drug Users Attending Methadone Maintenance Treatment(MMT) and Preventing Secondary Transmission From HIV Positive Clients to Their Sexual Partners in China Unknown status NCT01108614 Phase 3
16 A COMMUNITY-BASED, RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE EFFICACY OF COMPREHENSIVE HIV/STIs INTERVENTION AMONG MEN WHO HAVE SEX WITH MEN IN 8 CITIES IN CHINA Unknown status NCT01068015 Phase 3
17 Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
18 Optic Neuritis Treatment Trial (ONTT) Unknown status NCT00000146 Phase 3 Methylprednisolone;Prednisone
19 Maternal Genitourinary Infections and Adverse Perinatal Outcomes in Sylhet District, Bangladesh Unknown status NCT01572532 Phase 3
20 A Phase III Equivalence Trial of Azithromycin vs. Benzathine Penicillin for the Treatment of Early Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
21 Single-dose Azithromycin Versus Penicillin G Benzathine for the Treatment of Yaws in Children Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
22 Randomized Trial of Male Circumcision for HIV Prevention, Rakai, Uganda Completed NCT00425984 Phase 3
23 A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Acyclovir for the Reduction of HIV Acquisition Among High-Risk HSV-2 Seropositive, HIV Seronegative Individuals Completed NCT00076232 Phase 3 Acyclovir;Acyclovir placebo
24 Strategies for the Prevention of HIV Infection and the Enhancement of Reproductive Health Among Adolescents in Rural Tanzania: MEMA Kwa Vijana Trial Completed NCT00248469 Phase 3
25 Impact of Episodic Acyclovir Therapy on Ulcer Duration and HIV Shedding From Genital Ulcers Among Men in South Africa Completed NCT00164424 Phase 2, Phase 3 Acyclovir
26 Impact of the Rapid Expansion of Pre-exposure Prophylaxis (PrEP) on HIV Incidence, in a Setting With High HIV Testing and Antiretroviral Treatment Coverage, to Achieve the Virtual Elimination of HIV Transmission by 2020: a NSW HIV Strategy Implementation Project Active, not recruiting NCT02870790 Phase 3 TDF/FTC
27 A Randomized, Controlled, Double-blind, Phase 3 Trial to Evaluate the Effects of Maternal or Neonatal Pneumococcal Conjugate Vaccination on Pneumococcal Carriage in Infants up to Nine Months of Age - The PROPEL Trial Active, not recruiting NCT02628886 Phase 3
28 Randomized Trial to Evaluate Mirasol Whole Blood Pathogen Reduction Technology System to Reduce Malaria and Emerging Transfusion Transmitted Infections Not yet recruiting NCT03737669 Phase 3
29 A Randomized Trial of Spectroscopy Versus Standard Care in Cervical Intraepithelial Neoplasia Terminated NCT00529464 Phase 3
30 Randomised Placebo Controlled Trial of Faecal Microbiota Transplantation in Irritable Bowel Syndrome Unknown status NCT02423421 Phase 2
31 HoMBReS: A Lay Health Advisor Approach to Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
32 Computer-assisted STD Partner Notification Completed NCT00207571 Phase 1, Phase 2
33 A Randomized Controlled Clinical Trial of an Internet-based Prevention Intervention to Reduce STI in High-risk HIV Infected MSM Completed NCT01198418 Phase 1, Phase 2
34 Development of a Methamphetamine Early Intervention Completed NCT01174654 Phase 1, Phase 2
35 A Randomized, Placebo-controlled, Double-blind Trial to Assess Expanded Safety, Acceptability and Preliminary Effectiveness of PC-515 (Lambda Carrageenan) for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2 Carraguard (PC-515)
36 A Trial to Assess Expanded Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing STI/HIV Transmission Completed NCT00213018 Phase 2 Carraguard (PC-515)
37 Randomized, Single-centre, Double-blind, Placebo-controlled, Phase I / IIa Study to Evaluate the Safety and Efficacy of Human Autologous Hair Follicle Dermal Sheath Cup Cells (DSCC) in Women and Men With Androgenetic Alopecia. Completed NCT01286649 Phase 1, Phase 2
38 Biobehavioral Interventions for HIV-negative Methamphetamine-using MSM Completed NCT00856323 Phase 2 Truvada
39 Fecal Microbiota Transplantation by Colonoscopy for Recurrent C. Difficile Infection: an Open-label Randomized Clinical Trial Completed NCT02148601 Phase 2 Standard Antibiotic Therapy;Vancomycin (before randomization)
40 Couples Based HIV/STI Prevention for Injecting Drug Users in Kazakhstan Completed NCT01690442 Phase 2
41 A Brief, Clinic-Based, Safer Sex Program for Young African-American Men Completed NCT01439503 Phase 2
42 Intra-articular Injections of Platelet-rich Plasma in Patients With Knee Pain of Articular Cartilage Origin (Degenerative Chondropathy and Early OA). Completed NCT01747018 Phase 1, Phase 2
43 Phase II Pilot Study to Estimate the Adverse Events Associated With the Lock Solution When Used to Salvage Central Venous Catheter (CVC) in the Setting of a Central Line Associated Bloodstream Infection (CLABSI) Completed NCT01539343 Phase 2 Antimicrobial Solution
44 Randomized Clinical Trial: Single Versus Multiple-infusion Fecal Microbiota Transplantation for Severe Clostridium Difficile Infection Completed NCT03427229 Phase 2 Vancomycin (before randomization)
45 AN OPEN LABEL, BALANCED, RANDOMIZED, TWO-TREATMENT, TWO-PERIOD, TWO-SEQUENCE, CROSSOVER, SINGLE ORAL DOSE, BIOEQUIVALENCE STUDY OF METFORMIN 1000 MG TABLETS MANUFACTURED BY SAVIPHARM J.S.C, VIETNAM AND GLUCOPHAGE® 1000 MG TABLETS MANUFACTURED BY MERCK SANTE S.A.S.2, RUE DU PRESSOIR VERT-45400 SEMOY-FRANCE AND BE REGISTERED IN VIETNAM IN HEALTHY, ADULT, HUMAN MALE SUBJECTS UNDER FASTING CONDITION Completed NCT01710553 Phase 2
46 AN OPEN LABEL, BALANCED, RANDOMIZED, TWO-TREATMENT, TWO-PERIOD, TWO-SEQUENCE, CROSSOVER, SINGLE ORAL DOSE, BIOEQUIVALENCE STUDY OF METFORMIN GSK 850 MG TABLETS MANUFACTURED BY SAVIPHARM J.S.C, VIETNAM AND GLUCOPHAGE® 850 MG TABLETS MANUFACTURED BY MERCK SANTE S.A.S.2, RUE DU PRESSOIR VERT-45400 SEMOY-FRANCE AND BE REGISTERED IN VIETNAM IN HEALTHY, ADULT, HUMAN MALE SUBJECTS UNDER FASTING CONDITION Completed NCT01710540 Phase 2
47 AN OPEN LABEL, BALANCED, RANDOMIZED, TWO-TREATMENT, TWO-PERIOD, TWO-SEQUENCE, CROSSOVER, SINGLE ORAL DOSE, BIOEQUIVALENCE STUDY OF METFORMIN 500 MG TABLETS MANUFACTURED BY SAVIPHARM J.S.C, VIETNAM AND GLUCOPHAGE® 500 MG TABLETS MANUFACTURED BY MERCK SANTE S.A.S.2, RUE DU PRESSOIR VERT-45400 SEMOY-FRANCE AND BE REGISTERED IN VIETNAM IN HEALTHY, ADULT, HUMAN MALE SUBJECTS UNDER FASTING CONDITION Completed NCT01710527 Phase 2 Metformin 500mg;Glucophage 500mg
48 Clinical Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis Recruiting NCT03660488 Phase 2 Cefixime 400 milligram Oral Capsule [Suprax];Benzathine Penicillin G
49 The PREMISE Trial: A Novel Regimen to Prevent Malaria and Sexually Transmitted Infections in Pregnant Women With HIV Recruiting NCT03431168 Phase 2 Azithromycin/TMPS;Placebo/TMPS
50 Adjunctive Therapy With Telmisartan Instituted With ART During Acute HIV Infection to Reduce the Establishment of CNS Reservoirs of HIV and Lymph Node Fibrosis Active, not recruiting NCT02750059 Phase 2 TDF/3TC/EFV + Telmisartan;TDF/3TC/EFV only

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Benzylpenicillin
Ceftriaxone
Erythromycin
ERYTHROMYCIN PWDR
Minocycline
Tetracycline

Cochrane evidence based reviews: chancre

Genetic Tests for Syphilis

Anatomical Context for Syphilis

MalaCards organs/tissues related to Syphilis:

41
Testes, Skin, Bone, Liver, Eye, Lung, Heart

Publications for Syphilis

Articles related to Syphilis:

(show top 50) (show all 24050)
# Title Authors PMID Year
1
Syphilis. 38 17
31253629 2019
2
Perspectives on male partner notification and treatment for syphilis among antenatal women and their partners in Kampala and Wakiso districts, Uganda. 38 17
30727950 2019
3
Case 8-2019: A 58-Year-Old Woman with Vision Loss, Headaches, and Oral Ulcers. 17
30865802 2019
4
Antiphospholipid antibodies, antiphospholipid syndrome and infections. 9 38
18295729 2008
5
[Antiphospholipid syndrome: pathophysiology and clinicobiological aspects]. 9 38
19469420 2008
6
Intrathecal antitreponemal antibody synthesis determination using the INNO-LIA Syphilis Score. 9 38
18204743 2007
7
Effect of genital ulcer disease on HIV-1 coreceptor expression in the female genital tract. 9 38
18008231 2007
8
Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis. 9 38
17299719 2007
9
Hysteroscopy in the evaluation of patients with recurrent pregnancy loss: a cohort study in a primary care population. 9 38
15809790 2004
10
Factor V Leiden mutation in Sneddon syndrome. 9 38
12765305 2003
11
Anti-beta2-glycoprotein I antibodies in pediatric systemic lupus erythematosus and antiphospholipid syndrome. 9 38
12209489 2002
12
Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. 9 38
11491498 2001
13
Antiphospholipid antibody syndrome. A literature review. 9 38
11367816 2001
14
Different types of antiphospholipid antibodies in AIDS: a comparison with syphilis and the antiphospholipid syndrome. 9 38
10554081 1999
15
[The antiphospholipid syndrome--yesterday, today, tomorrow]. 9 38
9623352 1998
16
Antiphospholipid antibodies: guidelines for determination. 9 38
19078229 1997
17
Update: antiphospholipid antibodies. 9 38
19078201 1997
18
[The incidence of the antiphospholipid syndrome in the clinical and biological manifestations of systemic lupus erythematosus]. 9 38
9424663 1997
19
Antibodies to beta2-glycoprotein I--a specific marker for the antiphospholipid syndrome. 9 38
9276526 1997
20
Lupus anticoagulants: diagnostic dilemma and clinical challenge. 9 38
10169622 1997
21
Autoantibodies to phospholipids and to the coagulation proteins in AIDS. 9 38
9184392 1997
22
Prevalence and clinical significance of IgG isotype anti-beta 2-glycoprotein I antibodies in antiphospholipid syndrome: a comparative study with anticardiolipin antibodies. 9 38
9142046 1997
23
Antiphospholipid antibodies and atherosclerosis. 9 38
8902778 1996
24
Reactivity to beta 2 glycoprotein I clearly differentiates anticardiolipin antibodies from antiphospholipid syndrome and syphilis. 9 38
8725711 1996
25
Anticardiolipin antibodies from syphilis and systemic lupus erythematosus induce leakage in cardiolipin vesicles. 9 38
8736113 1996
26
Antibodies to phospholipid-free beta 2-glycoprotein-I in patients with primary antiphospholipid syndrome. 9 38
8991988 1995
27
Prevalence of antiphospholipid antibodies in patients with ankylosing spondylitis. 9 38
8991987 1995
28
Comparison of the effects of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation. 9 38
7667838 1995
29
Presence of multiple anti-phospholipid antibody specificities in a pediatric population. 9 38
8679908 1995
30
[A case of systemic lupus erythematosus associated with severe fibrinoid necrosis located mainly in the glomerular afferent arteriole]. 9 38
7699957 1995
31
[Middle cerebral artery occlusion with unilateral moyamoya like vessels and with ruptured anterior cerebral artery aneurysm--its relation to the antiphospholipid antibody syndrome]. 9 38
7826715 1994
32
Association of antimitochondrial antibodies type 5 and anti-beta 2 glycoprotein I antibodies in the antiphospholipid syndrome. 9 38
7799349 1994
33
Differences in functional activity of anticardiolipin antibodies from patients with syphilis and those with antiphospholipid syndrome. 9 38
8063429 1994
34
Clinical and therapeutic aspects associated to phospholipid binding antibodies (lupus anticoagulant and anticardiolipin antibodies). 9 38
7988946 1994
35
[Primary antiphospholipid syndrome: clinical and biological study of 36 cases]. 9 38
8189783 1994
36
Postpartum myocardial infarction in a patient with antiphospholipid syndrome. 9 38
8155200 1994
37
Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. 9 38
7918046 1993
38
High prevalence of anti-cardiolipin antibody, C1q-, C3d-, and mRF-IgG immune complexes, and anti-nuclear antibody in hemophiliacs irrespective of infection with human immunodeficiency virus type 1. 9 38
8410668 1993
39
Lupoid sclerosis with antiphospholipid and antimyelin antibodies. 9 38
8496878 1993
40
Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2-glycoprotein I. 9 38
1522218 1992
41
Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. 9 38
1602135 1992
42
Antiphospholipid antibody syndrome: a case report and review of the literature. 9 38
1801188 1991
43
[Anticardiolipin antibodies in diffuse connective tissue diseases with IgG, IgM and IgA isotypes]. 9 38
2267732 1990
44
Vasculopathy associated with the antiphospholipid antibody syndrome. 9 38
2189163 1990
45
Biological true and false serological tests for syphilis: their relationship with anticardiolipin antibodies. 9 38
2340925 1990
46
Epidemiology of Treponema pallidum, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and herpes simplex virus type 2 among female sex workers in the Middle East and North Africa: systematic review and meta-analytics. 38
31360448 2019
47
Prevalence of genital and oropharyngeal chlamydia and gonorrhoea among female sex workers in Melbourne, Australia, 2015-2017: need for oropharyngeal testing. 38
31113904 2019
48
Sexually Transmitted Infections Detected During and After Incarceration Among People with Human Immunodeficiency Virus: Prevalence and Implications for Screening and Prevention. 38
31415042 2019
49
Differences in sexually transmitted infection risk comparing preexposure prophylaxis users and propensity score matched historical controls in a clinic setting. 38
31149948 2019
50
Spectral optical coherence tomography findings in an adult patient with syphilitic bilateral posterior uveitis and unilateral punctate inner retinitis. 38
31211286 2019

Variations for Syphilis

Copy number variations for Syphilis from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 111152 17 35097918 35138441 Copy number ERBB2 Syphilis

Expression for Syphilis

Search GEO for disease gene expression data for Syphilis.

Pathways for Syphilis

GO Terms for Syphilis

Cellular components related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.87 MYH9 FN1 FAS CP CAT B2M
2 extracellular region GO:0005576 9.76 FN1 FAS CP CD40LG CD209 CAT
3 endoplasmic reticulum lumen GO:0005788 9.56 FN1 CP CD4 B2M
4 external side of plasma membrane GO:0009897 9.35 CD79A CD40LG CD4 CD209 B2M
5 cell surface GO:0009986 9.1 FAS CD40LG CD4 CD209 B2M APOH

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.62 TPR POLA1 CD4 CD209
2 regulation of calcium ion transport GO:0051924 9.46 CD4 BCL2
3 leukocyte cell-cell adhesion GO:0007159 9.43 CD40LG CD209
4 B cell differentiation GO:0030183 9.43 CD79A CD40LG BCL2
5 response to cadmium ion GO:0046686 9.4 CAT B2M
6 regulation of defense response to virus by virus GO:0050690 9.37 CD4 B2M
7 positive regulation of T cell proliferation GO:0042102 9.33 CD40LG CD4 CD209
8 negative regulation of myeloid cell apoptotic process GO:0033033 8.96 BCL2 APOH
9 B cell proliferation GO:0042100 8.8 CD79A CD40LG BCL2

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.43 TPR MYH9 CD79A CD4 CAT BCL2
2 identical protein binding GO:0042802 9.17 FN1 FAS CD4 CAT BCL2 B2M
3 protein membrane anchor GO:0043495 9.16 TPR MYH9
4 protein binding GO:0005515 10.07 TPR POLA1 MYH9 FN1 FAS DDX41

Sources for Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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