Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Syphilis

Summaries for Syphilis

MedlinePlus : 44 Syphilis is a sexually transmitted disease caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy. The early stage of syphilis usually causes a single, small, painless sore. Sometimes it causes swelling in nearby lymph nodes. If you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. Many people do not notice symptoms for years. Symptoms can go away and come back. The sores caused by syphilis make it easier to get or give someone HIV during sex. If you are pregnant, syphilis can cause complications, or you could lose your baby. In rare cases, syphilis causes serious health problems and even death. Syphilis is easy to cure with antibiotics if you catch it early. Correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex. Centers for Disease Control and Prevention

MalaCards based summary : Syphilis, also known as chancre, is related to late congenital syphilis and tertiary syphilis, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Doxycycline and Emtricitabine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and lymph node, and related phenotypes are cellular and homeostasis/metabolism

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC : 3 Syphilis can have very serious complications when left untreated.

Wikipedia : 77 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 446)
# Related Disease Score Top Affiliating Genes
1 late congenital syphilis 33.9 DDX41 EXTL3
2 tertiary syphilis 33.6 DDX41 EXTL3 MYH9
3 primary syphilis 32.8 DDX41 EXTL3 MYH9 POLA1
4 congenital syphilis 32.7 CD40LG CD79A DDX41 EXTL3 MYH9 POLA1
5 asymptomatic neurosyphilis 32.5 DDX41 EXTL3 MYH9
6 tertiary neurosyphilis 32.4 DDX41 EXTL3 MYH9
7 latent syphilis 32.4 DDX41 EXTL3 MYH9 POLA1 TPR
8 secondary syphilis 32.1 CD40LG CD79A DDX41 EXTL3 FN1 POLA1
9 tabes dorsalis 32.0 DDX41 EXTL3
10 yaws 30.9 EXTL3 TPR
11 sporotrichosis 30.2 CD40LG CD79A
12 connective tissue disease 30.1 APOH CD40LG PPIB
13 meningoencephalitis 29.8 B2M CD40LG CD79A
14 cardiovascular syphilis 12.6
15 early congenital syphilis 12.4
16 gummatous syphilis 12.4
17 bejel 12.2
18 neurosyphilis 12.1
19 syphilitic aseptic meningitis 12.0
20 paroxysmal cold hemoglobinuria 11.5
21 aortic aneurysm, familial thoracic 1 11.5
22 pinta disease 11.3
23 mikulicz disease 11.0
24 chronic rhinitis 11.0
25 idiopathic hypertrophic pachymeningitis 11.0
26 torch syndrome 11.0
27 progressive locomotor ataxia 11.0
28 syphilitic spinal sclerosis 11.0
29 hepatitis 10.7
30 hepatitis b 10.6
31 hepatitis c 10.5
32 human immunodeficiency virus infectious disease 10.4
33 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.4
34 chlamydia 10.4
35 c1q nephropathy 10.4 CD40LG CD79A
36 immunoglobulin g deficiency 10.4 CD40LG CD79A
37 heparin-induced thrombocytopenia 10.4 CD40LG CD79A
38 erythema infectiosum 10.4 APOH CD40LG
39 immunoglobulin a deficiency 1 10.4 CD40LG CD79A
40 immunodeficiency-centromeric instability-facial anomalies syndrome 1 10.4 CD40LG CD79A
41 ocular toxoplasmosis 10.4 CD40LG CD79A
42 catastrophic antiphospholipid syndrome 10.4 APOH CD40LG
43 congenital rubella 10.4 CAT CD40LG
44 persistent generalized lymphadenopathy 10.4 CD40LG CD79A
45 immunodeficiency with hyper-igm, type 1 10.3 CD40LG CD79A
46 non-secretory myeloma 10.3 B2M FN1
47 solitary osseous plasmacytoma 10.3 B2M CD79A
48 nephrotic syndrome 10.3
49 congenital toxoplasmosis 10.3 CD40LG CD79A
50 herpes simplex 10.3

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):

Acute Cystitis Deficiency Anemia
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Syphilis:

Diseases related to Syphilis

Symptoms & Phenotypes for Syphilis

UMLS symptoms related to Syphilis:

fever, pruritus, pelvic pain, syphilitic chancre, gummatous inflammation

MGI Mouse Phenotypes related to Syphilis:

# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 B2M BCL2 CAT CD40LG CD79A EXTL3
2 homeostasis/metabolism MP:0005376 9.9 APOH B2M BCL2 CAT CD40LG CD79A
3 mortality/aging MP:0010768 9.7 APOH B2M BCL2 CAT CD40LG DDX41
4 neoplasm MP:0002006 9.1 B2M BCL2 CAT CD79A FN1 NLRP12

Drugs & Therapeutics for Syphilis

Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 123)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 564-25-0 54671203
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 143491-57-0 60877
Tenofovir Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 147127-20-6 464205
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-46-1 4914
Penicillin G Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 61-33-6 5904
6 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
7 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
8 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
10 Antimalarials Phase 4,Phase 3,Not Applicable,Early Phase 1
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Antiparasitic Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
14 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
15 Antiviral Agents Phase 4,Phase 3,Phase 2,Not Applicable
16 Vaccines Phase 4,Phase 3,Phase 2
17 Penicillin G Benzathine Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 penicillins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Penicillin G Procaine Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 alanine Phase 4
21 N-Methylaspartate Phase 4
22 Aspartic Acid Phase 4
23 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4,Phase 3,Phase 2,Not Applicable
Methadone Approved, Illicit Phase 3,Not Applicable 76-99-3 4095
Guaifenesin Approved, Investigational, Vet_approved Phase 3,Not Applicable 93-14-1 3516
Azithromycin Approved Phase 3,Phase 2 83905-01-5 447043 55185
carbamide peroxide Approved Phase 3 124-43-6
Nelfinavir Approved Phase 3 159989-64-7 64143
Zidovudine Approved Phase 3 30516-87-1 35370
Nevirapine Approved Phase 3 129618-40-2 4463
Lamivudine Approved, Investigational Phase 3 134678-17-4 60825
leucovorin Approved Phase 3 58-05-9 143 6006
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
mometasone furoate Approved, Investigational, Vet_approved Phase 3 83919-23-7
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
Piperaquine Experimental, Investigational Phase 3 4085-31-8 5079497
Dihydroartemisinin Experimental, Investigational Phase 3 71939-50-9 6918483
41 Narcotics Phase 3,Not Applicable
42 Analgesics Phase 3,Not Applicable
43 Chlorpheniramine, phenylpropanolamine drug combination Phase 3,Not Applicable
44 Central Nervous System Depressants Phase 3,Not Applicable
Heroin Phase 3,Not Applicable 5462328
46 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2,Not Applicable
47 Antitussive Agents Phase 3,Not Applicable
48 Analgesics, Opioid Phase 3,Not Applicable
49 Respiratory System Agents Phase 3,Not Applicable
50 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 169)
# Name Status NCT ID Phase Drugs
1 Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM Unknown status NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
2 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
3 HPTN 073 Black Men Who Have Sex With Men (MSM) Pre-Exposure Prophylaxis (PrEP) Completed NCT01808352 Phase 4 FTC/TDF
4 PRe-Exposure Prophylaxis Acceptability & Readiness Assessments for Toronto gaY, Bisexual and Other Men Who Have Sex With Men-5 Completed NCT02149888 Phase 4 Tenofovir/emtricitabine
5 Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin Recruiting NCT02884115 Phase 4 benzathine penicillin
6 Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection Recruiting NCT03637660 Phase 4 Benzathine Penicillin
7 One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis Recruiting NCT02857959 Phase 4 Benzathine Penicillin G
8 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Recruiting NCT02871505 Phase 4 Benzathine Penicillin G
9 PrEP Implementation for Mothers in Antenatal Care Recruiting NCT03070600 Phase 4 Universal PrEP Counseling;Targeted PrEP Counseling
10 Hepatitis B Virus Vaccination in HIV-positive Patients and Individuals at High Risk for HIV Infection Recruiting NCT03854630 Phase 4 Engerix-B
11 Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia Unknown status NCT02454816 Phase 2, Phase 3
12 (Men Who Have Sex With Men) MSM Community Intervention Trial Unknown status NCT01068015 Phase 3
13 Injecting Drug Use Community Intervention Trial Unknown status NCT01108614 Phase 3
14 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
15 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
16 Male Circumcision for HIV Prevention in Rakai, Uganda Completed NCT00425984 Phase 3
17 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3 Carraguard (PC-515)
18 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
19 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
20 Reducing Sexual Risk Behaviors and Improving Health for People at a Sexually Transmitted Infection Clinic Completed NCT00947271 Phase 3
21 Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Prevention in Men Completed NCT00458393 Phase 3 daily TDF/FTC;Placebo
22 Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV Transmission Completed NCT00099359 Phase 3 Zidovudine;Nevirapine (NVP);Epivir (3TC);Nelfinavir (NFV)
23 MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania Completed NCT00248469 Phase 3
24 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
25 Evaluation of the Long Term Safety, Tolerability and Efficacy of Two Dosing Regimens of Olokizumab (OKZ), in Subjects With Rheumatoid Arthritis (RA) Who Previously Completed 24 Weeks of Blinded Treatment in One of the Core Studies - CREDO 1, 2 or 3. Recruiting NCT03120949 Phase 3 Olokizumab 64 mg SC q4w;Olokizumab 64 mg SC q2w;Methotrexate
26 Expanded PrEP Implementation in Communities in NSW Active, not recruiting NCT02870790 Phase 3 TDF/FTC
27 Western Australian Pre-exposure Prophylaxis for HIV Implementation Trial Active, not recruiting NCT03327155 Phase 3 Tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)
28 Protecting From Pneumococcus in Early Life (The PROPEL Trial) Active, not recruiting NCT02628886 Phase 3
29 Mirasol Evaluation of Reduction in Infections Trial Not yet recruiting NCT03737669 Phase 3
30 Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa Not yet recruiting NCT03208179 Phase 3 dihydroartemisinin-piperaquine;sulphadoxine-pyrimethamine;dihydroartemisinin-piperaquine plus azithromycin
31 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3 Azithromycin plus chloroquine;sulfadoxine-pyrimethamine
32 Effectiveness of the Diaphragm for HIV Prevention Withdrawn NCT00121459 Phase 3
33 A Web-based Intervention Study to Reduce High-risk Sexual Behavior by Persons Living With HIV AIDS (PLWH) Completed NCT01198418 Phase 1, Phase 2
34 Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission Completed NCT00213018 Phase 2 Carraguard (PC-515)
35 Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2 Carraguard (PC-515)
36 Behavioral Intervention to Reduce Sexual and Injection Risks Among Female Sex Workers Who Also Inject Drugs in Mexico Completed NCT00840658 Phase 2
37 Lay Health Advisors for Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
38 Safety and Efficacy Study of Human Autologous Hair Follicle Cells to Treat Androgenetic Alopecia Completed NCT01286649 Phase 1, Phase 2
39 Development of a Methamphetamine Early Intervention Completed NCT01174654 Phase 1, Phase 2
40 Safer Sex Program for Young African-American Men Completed NCT01439503 Phase 2
41 Comprehensive Triaged HIV Prevention in Tanzania Completed NCT02018978 Phase 2
42 A Tolerability and Efficacy Study of TU-100 For The Treatment of Postoperative Ileus Completed NCT00266461 Phase 2 Daikenchuto Extract Granules (TU-100)
43 Contingency Management for Methamphetamine Abstinence and HIV Post-Exposure Prophylaxis in Men Who Have Sex With Men Completed NCT00856323 Phase 2 Truvada
44 BufferGel and PRO 2000/5: Vaginal Gels to Prevent HIV Infection in Women Completed NCT00074425 Phase 2 BufferGel;PRO 2000/5 Gel;Placebo gel
45 Cefixime for Alternative Syphilis Treatment Recruiting NCT03660488 Phase 2 Cefixime 400 milligram Oral Capsule [Suprax];Benzathine Penicillin G
46 A Novel Regimen to Prevent Malaria and STI in Pregnant Women With HIV Recruiting NCT03431168 Phase 2 Azithromycin/TMPS;Placebo/TMPS
47 A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus Recruiting NCT03617536 Phase 2 CR845 0.25 mg Oral Tablet;CR845 0.5 mg Oral Tablet;CR845 1 mg Oral Tablet;Placebo Oral Tablet
48 Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas Recruiting NCT02503423 Phase 1, Phase 2 ASTX660
49 Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women Not yet recruiting NCT03752112 Phase 1, Phase 2 Cefixime;Benzathine penicillin 2.4 million units
50 Optimizing the Delivery of HIV nPEP Not yet recruiting NCT03259698 Phase 2 nPEP

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: chancre

Genetic Tests for Syphilis

Anatomical Context for Syphilis

MalaCards organs/tissues related to Syphilis:

Testes, Skin, Lymph Node, Tongue, T Cells, Eye, Tonsil

Publications for Syphilis

Articles related to Syphilis:

(show top 50) (show all 4925)
# Title Authors Year
Moth-eaten alopecia in secondary syphilis. ( 30807867 )
All eyes on him: Argyll Robertson pupil in late syphilis. ( 30904677 )
Syphilis with Charcot arthropathy: a case report. ( 30758895 )
Syphilitic Cervicitis with Cervical Cancer Presenting as Oropharyngeal Syphilis: A Case Report. ( 30996173 )
Sexual network characteristics of men who have sex with men with syphilis and/or gonorrhoea/chlamydia in Lima, Peru: network patterns as roadmaps for STI prevention interventions. ( 31010954 )
Prevalence, incidence and predictors of anal Chlamydia trachomatis, anal Neisseria gonorrhoeae and syphilis among older gay and bisexual men in the longitudinal Study for the Prevention of Anal Cancer (SPANC). ( 31018992 )
Cholangitis and pulmonary nodules in a clinical presentation of syphilis in an HIV-infected patient. ( 31046616 )
Sensitivity of nPCR for four types of membrane protein DNA and of two pairs of primers for Tpp47 DNA of Treponema pallidum in whole blood of congenital syphilis newborns. ( 28889773 )
Global burden of maternal and congenital syphilis and associated adverse birth outcomes-Estimates for 2016 and progress since 2012. ( 30811406 )
Risk Factors for Congenital Syphilis Transmitted from Mother to Infant - Suzhou, China, 2011-2014. ( 30870407 )
Correction: Fetal and infant mortality of congenital syphilis reported to the Health Information System. ( 30889201 )
Evaluating congenital syphilis in a reverse sequence testing environment. ( 31076626 )
Evolution towards the elimination of congenital syphilis in Latin America and the Caribbean: a multicountry analysis. ( 31093255 )
Antibiotic treatment for newborns with congenital syphilis. ( 30776081 )
TPPA titer as a new adaptation for early diagnosis of congenital syphilis: a retrospective analysis of observation over three years in Yunnan, China. ( 30711012 )
Fetal and infant mortality of congenital syphilis reported to the Health Information System. ( 30608958 )
Preventing Congenital Syphilis-Opportunities Identified by Congenital Syphilis Case Review Boards. ( 30169475 )
Congenital syphilis presenting with liver lesions. ( 30114994 )
Syphilis associated with recreational drug use, depression and high-risk sexual behaviour in men who have sex with men: a case-control study in China. ( 30842346 )
Russell Body Dermatitis Due to Syphilis. ( 30301391 )
Secondary syphilis presenting as erythema multiforme in a HIV-positive homosexual man: a case report and literature review. ( 30482099 )
Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association. ( 30669309 )
Gummatous Syphilis Mimicking Malignant Bone Tumor on FDG PET/CT. ( 30672757 )
HIV, syphilis, and viral hepatitis among Latin American indigenous peoples and Afro-descendants: a systematic review. ( 31093241 )
High prevalence of hepatitis B and syphilis in illegal gold miners in French Guiana. ( 31035016 )
Evaluating progress towards triple elimination of mother-to-child transmission of HIV, syphilis and hepatitis B in the Netherlands. ( 30922277 )
Integrated approach for triple elimination of mother-to-child transmission of HIV, hepatitis B and syphilis is highly effective and cost-effective: an economic evaluation. ( 30879066 )
Hepatitis in patients with syphilis: an overlooked association. ( 30696640 )
Optimization strategies for HIV, hepatitis and syphilis testing in Infectious Disease Clinic and Dermatology Unit of Modena: 7-year results of collaboration experience. ( 30520146 )
Cervical syphilitic lymphadenitis causing fever of unknown origin followed by rash of secondary syphilis. ( 30971574 )
Integrated point-of-care testing (POCT) for HIV, syphilis, malaria and anaemia at antenatal facilities in western Kenya: a qualitative study exploring end-users' perspectives of appropriateness, acceptability and feasibility. ( 30691447 )
Risk of neurosyphilis in HIV-infected persons with syphilis lacking signs or symptoms of central nervous system infection. ( 30402918 )
Analysis of EEG Lemple-Ziv complexity and correlative aspects before and after treatment of anti-syphilis therapy for neurosyphilis. ( 30912484 )
A Rare Case of Neurosyphilis with Ocular Involvement in a Patient with HIV Infection and New Onset Syphilis. ( 31011497 )
Profile of the tprK gene in primary syphilis patients based on next-generation sequencing. ( 30789907 )
Evaluation of the Abbott ARCHITECT™ cytomegalovirus IgM/IgG, rubella IgM/IgG, and syphilis treponemal antibodies enzyme immunoassays in a mother and child health center population. ( 30738692 )
Altered Appearance of Secondary Syphilis Rash Within a Preexisting Tattoo. ( 30363028 )
Annular secondary syphilis. ( 30616335 )
Rounded atrophic areas on the dorsum of the tongue: plaques en prairie fauchée of secondary syphilis. ( 30622897 )
Nodulo-ulcerative and erythrodermic secondary syphilis in human immunodeficiency virus-infected individuals. ( 30630397 )
Vegetating lesions in secondary syphilis. ( 30748034 )
Increased Methamphetamine, Injection Drug, and Heroin Use Among Women and Heterosexual Men with Primary and Secondary Syphilis - United States, 2013-2017. ( 30763294 )
Lichenoid skin lesions: A rare manifestation in secondary syphilis. ( 30785122 )
Geographic correlates of primary and secondary syphilis among men who have sex with men in the United States. ( 30799206 )
Dermoscopic clues in the skin lesions of secondary syphilis. ( 30899465 )
Vegetating lesions in secondary syphilis. Reply from authors. ( 30941790 )
Biett's sign: a hallmark sign of secondary syphilis. ( 30994813 )
Immune reconstitution inflammatory syndrome associated with secondary syphilis: dermatologic, neurologic and ophthalmologic compromise in an HIV patient. ( 30999832 )
Beyond appearance: An unusual manifestation of isolated oral secondary syphilis. ( 31020874 )
In Response To: Lapere S, Mustak H and Steffen J. "Clinical Manifestations and Cerebrospinal Fluid Status in Ocular Syphilis". ( 31020868 )

Variations for Syphilis

Copy number variations for Syphilis from CNVD:

# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 111152 17 35097918 35138441 Copy number ERBB2 Syphilis

Expression for Syphilis

Search GEO for disease gene expression data for Syphilis.

Pathways for Syphilis

GO Terms for Syphilis

Cellular components related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 APOH B2M CAT FN1 HLA-C MYH9
2 endoplasmic reticulum GO:0005783 9.63 BCL2 CAT DDX41 EXTL3 HLA-C PPIB
3 focal adhesion GO:0005925 9.26 B2M CAT MYH9 PPIB
4 MHC class I protein complex GO:0042612 8.62 B2M HLA-C

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell differentiation in thymus GO:0033077 9.46 B2M BCL2
2 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.43 B2M HLA-C
3 response to cadmium ion GO:0046686 9.4 B2M CAT
4 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.37 B2M HLA-C
5 B cell differentiation GO:0030183 9.33 BCL2 CD40LG CD79A
6 positive regulation of T cell mediated cytotoxicity GO:0001916 9.32 B2M HLA-C
7 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.26 B2M HLA-C
8 negative regulation of myeloid cell apoptotic process GO:0033033 8.96 APOH BCL2
9 B cell proliferation GO:0042100 8.8 BCL2 CD40LG CD79A

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 APOH B2M BCL2 CD40LG CD79A DDX41
2 protein homodimerization activity GO:0042803 9.35 BCL2 CAT CD79A MYH9 TPR
3 protein membrane anchor GO:0043495 8.62 MYH9 TPR

Sources for Syphilis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
33 HPO
34 ICD10
35 ICD10 via Orphanet
39 LifeMap
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
56 Novoseek
59 OMIM via Orphanet
63 PubMed
71 SNOMED-CT via Orphanet
73 Tocris
75 UMLS via Orphanet
Loading form....