MCID: SYP001
MIFTS: 22

Syphilitic Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Syphilitic Meningitis

MalaCards integrated aliases for Syphilitic Meningitis:

Name: Syphilitic Meningitis 12 15
Syphilitic Aseptic Meningitis 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10073
ICD9CM 35 094.2
MeSH 44 C536775
UMLS 73 C0153166

Summaries for Syphilitic Meningitis

MalaCards based summary : Syphilitic Meningitis, also known as syphilitic aseptic meningitis, is related to secondary syphilis and syphilis. An important gene associated with Syphilitic Meningitis is EXTL3 (Exostosin Like Glycosyltransferase 3). Affiliated tissues include b cells and t cells.

Related Diseases for Syphilitic Meningitis

Diseases related to Syphilitic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 secondary syphilis 29.4 CD40LG EXTL3
2 syphilis 29.3 CD40LG EXTL3
3 syphilitic aseptic meningitis 11.5
4 meningitis 10.4
5 early yaws 9.9 CD40LG EXTL3
6 primary syphilis 9.9 CD40LG EXTL3
7 optic papillitis 9.9 CD40LG EXTL3
8 tertiary syphilis 9.9 CD40LG EXTL3
9 latent syphilis 9.9 CD40LG EXTL3
10 congenital syphilis 9.9 CD40LG EXTL3
11 chorioretinitis 9.8 CD40LG EXTL3
12 asymptomatic neurosyphilis 9.8 CD40LG EXTL3
13 urethritis 9.8 CD40LG EXTL3
14 fournier gangrene 9.8 CD40LG SERPINC1
15 heparin-induced thrombocytopenia 9.8 CD40LG SERPINC1
16 japanese spotted fever 9.8 CD40LG SERPINC1
17 neuroretinitis 9.8 CD40LG EXTL3
18 tertiary neurosyphilis 9.8 CD40LG EXTL3
19 systemic lupus erythematosus 9.7
20 intracranial hypertension, idiopathic 9.7
21 papilledema 9.7
22 paraplegia 9.7
23 lupus erythematosus 9.7
24 hypopituitarism 9.7
25 tuberculous meningitis 9.7
26 korean hemorrhagic fever 9.7 CD40LG SERPINC1
27 hemorrhagic fever 9.7 CD40LG SERPINC1
28 legg-calve-perthes disease 9.7 CD40LG SERPINC1
29 branch retinal artery occlusion 9.7 CD40LG SERPINC1
30 primary bacterial infectious disease 9.7 CD40LG EXTL3
31 blood coagulation disease 9.7 CD40LG SERPINC1
32 hepatitis a 9.6 CD40LG SERPINC1
33 hemorrhagic disease 9.6 CD40LG SERPINC1
34 antiphospholipid syndrome 9.6 CD40LG SERPINC1
35 blood platelet disease 9.6 CD40LG SERPINC1
36 purpura 9.5 CD40LG SERPINC1
37 immune system disease 9.4 CD40LG SERPINC1
38 acquired immunodeficiency syndrome 9.4 CD40LG ITIH4
39 immune deficiency disease 9.2 CD40LG ITIH4
40 viral infectious disease 9.1 CD40LG ITIH4
41 human immunodeficiency virus infectious disease 9.1 CD40LG ENPEP ITIH4
42 behcet syndrome 9.0 CD40LG SERPINC1

Graphical network of the top 20 diseases related to Syphilitic Meningitis:



Diseases related to Syphilitic Meningitis

Symptoms & Phenotypes for Syphilitic Meningitis

Drugs & Therapeutics for Syphilitic Meningitis

Search Clinical Trials , NIH Clinical Center for Syphilitic Meningitis

Cochrane evidence based reviews: syphilitic aseptic meningitis

Genetic Tests for Syphilitic Meningitis

Anatomical Context for Syphilitic Meningitis

MalaCards organs/tissues related to Syphilitic Meningitis:

41
B Cells, T Cells

Publications for Syphilitic Meningitis

Articles related to Syphilitic Meningitis:

(show all 24)
# Title Authors Year
1
Comparative study of CD4 and CD45RO T cells and CD20 B cells in cerebrospinal fluid of syphilitic meningitis and tuberculous meningitis patients. ( 27467195 )
2016
2
Acute hypophysitis and hypopituitarism in early syphilitic meningitis in a HIV-infected patient: a case report. ( 24134407 )
2013
3
Tuberculous and syphilitic meningitis in a patient infected with the human immunodeficiency virus. ( 17409609 )
2007
4
Syphilitic meningitis in HIV-patients with meningeal syndrome: report of two cases and review. ( 11779455 )
2001
5
Concomitant human immunodeficiency virus infection and syphilitic meningitis. ( 9064008 )
1996
6
Acute syphilitic meningitis in a patient with systemic lupus erythematosus. ( 8336315 )
1993
7
Acute syphilitic meningitis in a man with seropositivity for human immunodeficiency virus infection and normal numbers of CD4 T lymphocytes. ( 1350899 )
1992
8
Syphilitic meningitis causing paraparesis in an HIV-negative woman. ( 1865231 )
1991
9
Chronic syphilitic meningitis resulting in superior orbital fissure syndrome and posterior fossa gumma. A report of two cases followed for 20 years. ( 2971679 )
1988
10
Syphilitic meningitis masquerading as pseudotumor cerebri. ( 3579655 )
1987
11
Acute syphilitic meningitis. Its occurrence after clinical and serologic cure of secondary syphilis with penicillin G. ( 3947251 )
1986
12
Acute syphilitic meningitis: a case report. ( 312449 )
1979
13
Syphilitic meningitis with papilledema. ( 887964 )
1977
14
Report of a case of probable syphilitic meningitis. ( 18891508 )
1948
15
Acute syphilitic meningitis; a report of 80 cases. ( 18895277 )
1948
16
Syphilitic meningitis with negative blood and spinal fluid serology, report of a rare syndrome. ( 20994580 )
1946
17
Acute syphilitic meningitis treated with penicillin; a progress report. ( 20984456 )
1946
18
Unilateral internal ophthalmoplegia; sole clinical sign in patient with syphilitic meningitis. ( 21012276 )
1945
19
Acute Syphilitic Meningitis Occurring During Treatment. ( 19992119 )
1939
20
Acute Syphilitic Meningitis with PapillA9dema. ( 20915455 )
1937
21
Acute Syphilitic Meningitis with Papilloedema. ( 19991058 )
1937
22
ACUTE SYPHILITIC MENINGITIS. ( 20768750 )
1917
23
Chronic Syphilitic Meningitis with Compression of the Cord. ( 19974515 )
1910
24
Compression Paraplegia: Syphilitic Meningitis. ( 19974507 )
1910

Variations for Syphilitic Meningitis

Expression for Syphilitic Meningitis

Search GEO for disease gene expression data for Syphilitic Meningitis.

Pathways for Syphilitic Meningitis

GO Terms for Syphilitic Meningitis

Cellular components related to Syphilitic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.62 ITIH4 SERPINC1

Biological processes related to Syphilitic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of endopeptidase activity GO:0010951 8.96 ITIH4 SERPINC1
2 negative regulation of peptidase activity GO:0010466 8.62 ITIH4 SERPINC1

Molecular functions related to Syphilitic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase inhibitor activity GO:0030414 8.96 ITIH4 SERPINC1
2 serine-type endopeptidase inhibitor activity GO:0004867 8.62 ITIH4 SERPINC1

Sources for Syphilitic Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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