MCID: SYP001
MIFTS: 31

Syphilitic Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Syphilitic Meningitis

MalaCards integrated aliases for Syphilitic Meningitis:

Name: Syphilitic Meningitis 12 20 15
Syphilitic Aseptic Meningitis 20 44 70
Meningitis, Syphilitic 20
Meningeal Syphilis 20

Classifications:



External Ids:

Disease Ontology 12 DOID:10073
ICD9CM 34 094.2
MeSH 44 C536775
SNOMED-CT 67 14968007
UMLS 70 C0153166

Summaries for Syphilitic Meningitis

Disease Ontology : 12 A bacterial meningitis that is characterized by inflammation of the tissues covering the brain and spinal cord.

MalaCards based summary : Syphilitic Meningitis, also known as syphilitic aseptic meningitis, is related to asymptomatic neurosyphilis and panophthalmitis. An important gene associated with Syphilitic Meningitis is CD4 (CD4 Molecule), and among its related pathways/superpathways are Allograft rejection and Innate Lymphoid Cell Differentiation Pathways. Affiliated tissues include spinal cord, bone and lung, and related phenotype is immune system.

Related Diseases for Syphilitic Meningitis

Diseases related to Syphilitic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 373)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 31.1 CXCL13 CD4
2 panophthalmitis 30.4 CRP CD4
3 secondary syphilis 30.3 CXCL13 CRP CD8A CD4
4 tabes dorsalis 30.3 TCHH CXCL13 CD4
5 syphilis 30.3 TNF CRP CD8A CD4 APOH
6 facial paralysis 30.0 TNF CRP CD8A CD4
7 aseptic meningitis 29.9 TNF CXCL13 CRP
8 papilledema 29.9 SERPINC1 CRP CD4 APOH
9 intracranial hypertension 29.7 TNF SERPINC1 APOH
10 immune deficiency disease 28.3 TNF ITIH4 CRP CD8A CD81 CD4
11 meningitis 10.7
12 cork-handlers' disease 10.4 CD8A CD4
13 necrotic uveal melanoma 10.4 CD8A CD4
14 early yaws 10.4 CD8A CD4
15 ventilation pneumonitis 10.4 CD8A CD4
16 diffuse infiltrative lymphocytosis syndrome 10.4 CD8A CD4
17 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
18 parapsoriasis 10.4 CD8A CD4
19 gastroduodenitis 10.4 CD8A CD4
20 norwegian scabies 10.4 CD8A CD4
21 bird fancier's lung 10.4 CD8A CD4
22 blue toe syndrome 10.4 SERPINC1 CRP
23 cerebral arteritis 10.4 SERPINC1 CRP
24 metal allergy 10.4 CD8A CD4
25 variola major 10.4 CD8A CD4
26 epidural abscess 10.4 CRP CD4
27 follicular mucinosis 10.4 CD8A CD4
28 pericardial tuberculosis 10.4 CRP CD4
29 urogenital tuberculosis 10.4 CRP CD4
30 spongiotic dermatitis 10.4 CD8A CD4
31 acute retinal necrosis syndrome 10.4 CD8A CD4
32 cavernous sinus thrombosis 10.4 SERPINC1 CRP
33 breast abscess 10.4 CRP CD4
34 gummatous syphilis 10.3 TCHH CRP
35 pyomyositis 10.3 CRP CD4
36 suppurative lymphadenitis 10.3 CRP CD4
37 cerebral lymphoma 10.3 CD8A CD4
38 neurosyphilis 10.3
39 splenic abscess 10.3 CRP CD4
40 latent syphilis 10.3 CXCL13 CD8A CD4
41 invasive malignant thymoma 10.3 CD8A CD4
42 orbital cellulitis 10.3 CRP CD4
43 acute orbital inflammation 10.3 CRP CD4
44 neuroretinitis 10.3 CRP CD4
45 intracranial sinus thrombosis 10.3 SERPINC1 CRP
46 west nile encephalitis 10.3 CD8A CD4
47 tertiary neurosyphilis 10.3 TCHH CXCL13 CD4
48 exanthema subitum 10.3 CD8A CD4
49 abducens nerve disease 10.3 SERPINC1 CRP
50 mediastinitis 10.3 CRP CD4

Graphical network of the top 20 diseases related to Syphilitic Meningitis:



Diseases related to Syphilitic Meningitis

Symptoms & Phenotypes for Syphilitic Meningitis

MGI Mouse Phenotypes related to Syphilitic Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 AICDA CD4 CD81 CD8A CRP CXCL13

Drugs & Therapeutics for Syphilitic Meningitis

Search Clinical Trials , NIH Clinical Center for Syphilitic Meningitis

Cochrane evidence based reviews: syphilitic aseptic meningitis

Genetic Tests for Syphilitic Meningitis

Anatomical Context for Syphilitic Meningitis

MalaCards organs/tissues related to Syphilitic Meningitis:

40
Spinal Cord, Bone, Lung, Skin, Lymph Node, T Cells, B Cells

Publications for Syphilitic Meningitis

Articles related to Syphilitic Meningitis:

(show top 50) (show all 86)
# Title Authors PMID Year
1
Molecular diagnostics, a strategy which does not address the diagnostic deficit in syphilitic meningitis. 61
31477353 2020
2
Neurosyphilis. 61
31533185 2019
3
Predictors of unfavorable outcome in neurosyphilis: Multicenter ID-IRI Study. 61
30368740 2019
4
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series. 61
29972419 2018
5
The clinical and laboratory features of neurosyphilis in HIV-infected patients: A retrospective study in 92 patients. 61
29489672 2018
6
Acute syphilitic meningitis in an HIV-infected patient. 61
30101068 2018
7
A Case of Early Neurosyphilis. 61
28414665 2017
8
Changes in neurosyphilis presentation: a survey on 286 patients. 61
27306850 2016
9
Comparative study of CD4 and CD45RO T cells and CD20 B cells in cerebrospinal fluid of syphilitic meningitis and tuberculous meningitis patients. 61
27467195 2016
10
Republication: Two Premature Neonates of Congenital Syphilis with Severe Clinical Manifestations. 61
26543391 2015
11
Subacute multicranial neuropathy revealing an early case of meningeal syphilis. 61
25739944 2015
12
Neurosyphilis: An Unresolved Case of Meningitis. 61
26075118 2015
13
Sudden-onset bilateral deafness revealing early neurosyphilis. 61
24880727 2014
14
Association between neurosyphilis and diabetes mellitus: resurgence of an old problem. 61
24393446 2014
15
[Brain and spine cord lesions caused by syphilis]. 61
24781221 2014
16
Acute hypophysitis and hypopituitarism in early syphilitic meningitis in a HIV-infected patient: a case report. 61
24134407 2013
17
[Syphilis and pregnancy: study of 94 cases]. 61
23510608 2013
18
Spectrum and characterization of movement disorders secondary to neurosyphilis. 61
23395216 2013
19
Laboratory findings in neurosyphilis patients with epileptic seizures alone as the initial presenting symptom. 61
23428457 2013
20
Clinical spectrum of neurosyphilis among HIV-negative patients in the modern era. 61
23615173 2013
21
Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients. 61
22482824 2012
22
Neurosyphilis presenting with psychotic symptoms and status epilepticus. 61
21468681 2012
23
Normalization of serum rapid plasma reagin titer predicts normalization of cerebrospinal fluid and clinical abnormalities after treatment of neurosyphilis. 61
18715154 2008
24
CT and MR findings in HIV-negative neurosyphilis. 61
17628376 2008
25
Tuberculous and syphilitic meningitis in a patient infected with the human immunodeficiency virus. 61
17409609 2007
26
Treatment of neurosyphilis. 61
16569377 2006
27
[Loss of cranial-nerve function caused by early syphilitic meningitis: the comeback of a pre-war syndrome]. 61
16078773 2005
28
[A case report of syphilitic meningitis with right oculomotor nerve palsy]. 61
12833888 2003
29
Syphilitic meningitis in HIV-patients with meningeal syndrome: report of two cases and review. 61
11779455 2001
30
Syphilitic posterior uveitis: correlative findings and significance. 61
11360205 2001
31
Concomitant human immunodeficiency virus infection and syphilitic meningitis. 61
9064008 1996
32
Acute syphilitic meningitis in a patient with systemic lupus erythematosus. 61
8336315 1993
33
Neurosyphilis. A comparative study of the effects of infection with human immunodeficiency virus. 61
8442701 1993
34
Acute syphilitic meningitis in a man with seropositivity for human immunodeficiency virus infection and normal numbers of CD4 T lymphocytes. 61
1350899 1992
35
Rapid response of syphilitic optic neuritis to posterior sub-tenon's steroid injection. 61
1532604 1992
36
Syphilis, neurosyphilis, penicillin, and AIDS. 61
2037785 1991
37
Syphilitic meningitis causing paraparesis in an HIV-negative woman. 61
1865231 1991
38
Effect of human immunodeficiency virus (HIV) infection on the course of syphilis and on the response to treatment. 61
2240901 1990
39
[A case of syphilitic meningitis presenting the seventh nerve and the eighth nerve palsies]. 61
2223261 1990
40
Neurosyphilis in AIDS patients: initial CSF VDRL may be negative. 61
2314600 1990
41
[Restless leg syndrome associated with syphilitic meningitis: a case report]. 61
2600506 1989
42
[Syphilitic meningitis presenting facial paralysis and the eighth nerve dysfunction. A case report]. 61
2746092 1989
43
Chronic syphilitic meningitis resulting in superior orbital fissure syndrome and posterior fossa gumma. A report of two cases followed for 20 years. 61
2971679 1988
44
Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus. 61
3587290 1987
45
Syphilitic meningitis masquerading as pseudotumor cerebri. 61
3579655 1987
46
[Diagnosis and forensic-psychiatric expert opinion in neurosyphilis]. 61
3434077 1987
47
Acute syphilitic meningitis. Its occurrence after clinical and serologic cure of secondary syphilis with penicillin G. 61
3947251 1986
48
Neurosyphilis. 61
3890813 1985
49
Auditory function in early syphilis. A follow up study. 61
6736754 1984
50
Luetic meningitis with gumma: clinical, radiographic, and neuropathologic features. 61
7194439 1981

Variations for Syphilitic Meningitis

Expression for Syphilitic Meningitis

Search GEO for disease gene expression data for Syphilitic Meningitis.

Pathways for Syphilitic Meningitis

GO Terms for Syphilitic Meningitis

Cellular components related to Syphilitic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 TNF MPL CD59 CD4 APOH
2 platelet dense granule lumen GO:0031089 8.62 ITIH4 APOH

Biological processes related to Syphilitic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood coagulation GO:0030193 8.96 SERPINC1 APOH
2 negative regulation of lipid storage GO:0010888 8.62 TNF CRP

Molecular functions related to Syphilitic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II protein binding GO:0042289 8.62 CD81 CD4

Sources for Syphilitic Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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