MCID: SYP005
MIFTS: 22

Syphilitic Myelopathy

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Syphilitic Myelopathy

MalaCards integrated aliases for Syphilitic Myelopathy:

Name: Syphilitic Myelopathy 53
Tabes Dorsalis 53 72

Classifications:



External Ids:

UMLS 72 C0039223

Summaries for Syphilitic Myelopathy

MalaCards based summary : Syphilitic Myelopathy, also known as tabes dorsalis, is related to tabes dorsalis and progressive locomotor ataxia. The drugs Parathyroid hormone and Teriparatide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and testes.

Wikipedia : 75 Tabes dorsalis, is a slow degeneration (specifically, demyelination) of the neural tracts primarily in... more...

Related Diseases for Syphilitic Myelopathy

Diseases related to Syphilitic Myelopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 tabes dorsalis 13.1
2 progressive locomotor ataxia 11.7
3 syphilitic spinal sclerosis 11.7
4 syphilis 10.8
5 arthropathy 10.6
6 ataxia and polyneuropathy, adult-onset 10.5
7 3-methylglutaconic aciduria, type iii 10.5
8 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.5
9 syringomyelia, noncommunicating isolated 10.3
10 trigeminal neuralgia 10.3
11 cerebrotendinous xanthomatosis 10.3
12 xanthomatosis 10.3
13 malaria 10.3
14 gastric ulcer 10.3
15 syringomyelia 10.3
16 tertiary syphilis 10.3
17 neuropathy 10.3
18 meningitis 10.3
19 adie pupil 10.2
20 facial spasm 10.2
21 immunoglobulin a deficiency 1 10.2
22 myositis 10.2
23 osteoporosis 10.2
24 pernicious anemia 10.2
25 ocular motor apraxia 10.2
26 adrenoleukodystrophy 10.2
27 meningioma, radiation-induced 10.2
28 meningioma, familial 10.2
29 intraocular pressure quantitative trait locus 10.2
30 bone mineral density quantitative trait locus 8 10.2
31 bone mineral density quantitative trait locus 15 10.2
32 deficiency anemia 10.2
33 immunoglobulin alpha deficiency 10.2
34 pain agnosia 10.2
35 spinal disease 10.2
36 syphilitic meningitis 10.2
37 primary optic atrophy 10.2
38 spinal meningioma 10.2
39 diphtheria 10.2
40 diabetic autonomic neuropathy 10.2
41 autonomic neuropathy 10.2
42 neurogenic bladder 10.2
43 polyneuropathy 10.2
44 argyll robertson pupil 10.2
45 duodenal ulcer 10.2
46 neuritis 10.2
47 myelitis 10.2
48 cellulitis 10.2
49 pyoderma 10.2
50 secretory meningioma 10.2

Graphical network of the top 20 diseases related to Syphilitic Myelopathy:



Diseases related to Syphilitic Myelopathy

Symptoms & Phenotypes for Syphilitic Myelopathy

Drugs & Therapeutics for Syphilitic Myelopathy

Drugs for Syphilitic Myelopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Phase 2 9002-64-6
2
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
3
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
4 Hormones Phase 2
5 Hormone Antagonists Phase 2
6 Calcium, Dietary Phase 2
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
8 Bone Density Conservation Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 To Study the Efficacy of Teriparatide in Improving Remodeling of Foot Bones in Chronic Charcot Neuroarthropathy in Patients With Diabetes Mellitus. Unknown status NCT02023411 Phase 2 Teriparatide
2 Biomarker for Duchenne Disease AN INTERNATIONAL, MULTICENTER, EPIDEMIOLOGICAL PROTOCOL Recruiting NCT02994030

Search NIH Clinical Center for Syphilitic Myelopathy

Genetic Tests for Syphilitic Myelopathy

Anatomical Context for Syphilitic Myelopathy

MalaCards organs/tissues related to Syphilitic Myelopathy:

41
Spinal Cord, Bone, Testes, Thalamus, Medulla Oblongata

Publications for Syphilitic Myelopathy

Articles related to Syphilitic Myelopathy:

(show top 50) (show all 356)
# Title Authors PMID Year
1
Neurosyphilis in the modern era: Literature review and case series. 38
31427238 2019
2
Classical syphilitic lesions from the museum. 38
30083909 2019
3
Predictors of unfavorable outcome in neurosyphilis: Multicenter ID-IRI Study. 38
30368740 2019
4
Neuroborreliosis and Neurosyphilis. 38
30273247 2018
5
Charcot osteoarthropathy of the knee secondary to neurosyphilis: a rare condition managed by a challenging arthrodesis. 38
30131415 2018
6
Syphilitic meningomyelitis presenting with visceral crisis: A case report. 38
30045319 2018
7
Neurosyphilis in patients with HIV. 38
29478035 2018
8
Neuropathic Arthropathy of the Glenohumeral Joint A Review of the Literature. 38
29799367 2018
9
Tabes dorsalis: Not, at all, "Elementary my dear Watson!" 38
28521659 2018
10
Dilated tonic pupils with tabes dorsalis in neurosyphilis as first manifestation of HIV/AIDS: a video report. 38
29545440 2018
11
DEVELOPMENT OF GANGLIONOPATHY AND TABETIC VISCERAL CRISES ON THE BACKGROUND OF POLYRADICULONEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY (CASE REPORT). 38
29578430 2018
12
Édouard Manet's Tabes Dorsalis: From Painful Ataxia to Phantom Limb. 38
30336456 2018
13
The big imitator strikes again: a case report of neurosyphilis in a patient with newly diagnosed HIV. 38
28220718 2017
14
Neurosyphilis in Africa: A systematic review. 38
28859081 2017
15
Subarachnoid Block-Induced Deafferentation Pain Successfully Treated with Pentazocine. 38
28978899 2017
16
[Neurosyphilis in Psychiatric Settings: Three Case Reports]. 38
28291299 2017
17
Nerve-stretching in the 19th century. 38
25697346 2016
18
Tabes Dorsalis and Argyll Robertson Pupils. 38
27959596 2016
19
Édouard Manet's Tabes Dorsalis: From Painful Ataxia to Phantom Limb. 38
27434214 2016
20
The Dercum-Muybridge Collaboration and the Study of Pathologic Gaits Using Sequential Photography. 38
26684421 2016
21
Canadian Public Health Laboratory Network laboratory guidelines for the diagnosis of neurosyphilis in Canada. 38
25798161 2015
22
Syringomyelia with Chiari I malformation presenting as hip charcot arthropathy: a case report and literature review. 38
25692057 2015
23
A clinical study of new cases of parenchymal neurosyphilis: has tabes dorsalis disappeared or been missed? 38
25321411 2015
24
Bilateral total knee arthroplasty for Charcot knees associated with tabes dorsalis. 38
25415801 2014
25
Do all Charcot Spine require surgery? 38
25257755 2014
26
Neurosyphilis in the mixed urban-rural community of the Netherlands. 38
25142195 2014
27
Erb's paraplegia with primary optic atrophy: Unusual presentation of neurosyphilis: Case report and review of literature. 38
25024583 2014
28
Moritz Heinrich Romberg (1795-1873): Early founder of neurology. 38
22711686 2014
29
Historical review: suspension therapy for the treatment of tabes dorsalis. 38
25228352 2014
30
Bilateral neuro-arthropathy of the ankle as a sequela of undiagnosed tabes dorsalis. 38
23623735 2013
31
The Dercum-Muybridge collaboration for sequential photography of neurologic disorders. 38
24145881 2013
32
Who was first to diagnose and report neuropathic arthropathy of the foot and ankle: Jean-Martin Charcot or Herbert William Page? 38
23765185 2013
33
Bilateral ulnar neuropathy at the elbow secondary to neuropathic arthropathy associated with syringomyelia. 38
23790822 2013
34
Spectrum and characterization of movement disorders secondary to neurosyphilis. 38
23395216 2013
35
Clinical spectrum of neurosyphilis among HIV-negative patients in the modern era. 38
23615173 2013
36
Wilhelm Erb's years in Leipzig (1880-1883) and their impact on the history of neurology. 38
24051758 2013
37
Charcot arthropathy of the wrist associated with cervical spondylotic myelopathy. 38
24353972 2012
38
[Jean Alfred Fournier: to 180th anniversary]. 38
23634617 2012
39
Charcot-Marie-Tooth disease presenting as a nonhealing ulcer in a 26-year-old man. 38
22371199 2012
40
Neurosyphillis presenting with normal pressure hydrocephalus in a 76 year old man. 38
23569521 2012
41
Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. 38
22330117 2011
42
Infectious myelopathies. 38
22810930 2011
43
Septic elbow in the setting of neuropathic joint as the initial presentation of a cervical syrinx. 38
21469625 2011
44
[MRI features of neurosyphilis]. 38
21440277 2011
45
"Fulfilling the chief of his duties as a physician": Harvey Cushing, selective dorsal rhizotomy and elective spine surgery for quality of life. 38
21250816 2011
46
Case report: Neuropathic arthropathy of the hip as a sequela of undiagnosed tertiary syphilis. 38
20151233 2010
47
General paresis of insane: A rarity or reality? 38
22174538 2010
48
Neuropathic arthropathy progressing with multiple joint involvement in the upper extremity due to syringomyelia and type I Arnold-Chiari malformation. 38
19547980 2010
49
Douglas Argyll Robertson (1837-1909) and his pupil. 38
20069387 2010
50
[Basic mechanism of magnetic human cerebellar stimulation and its clinical application]. 38
19999142 2009

Variations for Syphilitic Myelopathy

Expression for Syphilitic Myelopathy

Search GEO for disease gene expression data for Syphilitic Myelopathy.

Pathways for Syphilitic Myelopathy

GO Terms for Syphilitic Myelopathy

Sources for Syphilitic Myelopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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