SCAP
MCID: SYR002
MIFTS: 43

Syringocystadenoma Papilliferum (SCAP)

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Syringocystadenoma Papilliferum

MalaCards integrated aliases for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 12 77 54 60 15 17 74
Fistulous Vegetative Verrucous Hydradenoma 54 60
Naevus Syringocystadenomatosus Papilliferus 60
Syringadenoma Papilliferum 60
Papillary Syringadenoma 12
Papillary Hidradenoma 74
Scap 60

Characteristics:

Orphanet epidemiological data:

60
syringocystadenoma papilliferum
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal;

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:5445
MeSH 45 D000074009
NCIt 51 C4172
SNOMED-CT 69 8934006
ICD10 via Orphanet 35 D23.9
UMLS via Orphanet 75 C0406803
Orphanet 60 ORPHA840

Summaries for Syringocystadenoma Papilliferum

MalaCards based summary : Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to apocrine adenoma and hidradenoma. An important gene associated with Syringocystadenoma Papilliferum is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Cytoskeleton remodeling Neurofilaments and Signaling by ERBB4. Affiliated tissues include skin, breast and cervix, and related phenotypes are subcutaneous nodule and sparse scalp hair

Wikipedia : 77 Syringocystadenoma papilliferum is a benign apocrine... more...

Related Diseases for Syringocystadenoma Papilliferum

Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
# Related Disease Score Top Affiliating Genes
1 apocrine adenoma 31.3 KRAS MUC1
2 hidradenoma 30.9 MUC1 VIM
3 adenosquamous carcinoma 30.6 KRAS MUC1
4 cutaneous leiomyosarcoma 29.7 ACTC1 DES GFAP MUC1
5 leiomyosarcoma 29.4 ACTC1 DES S100B VIM
6 syringoma 29.3 DES GFAP MUC1 S100B VIM
7 dystonia, dopa-responsive, due to sepiapterin reductase deficiency 11.3
8 hypercholesterolemia, familial 11.1
9 adenoma 10.8
10 basal cell carcinoma 1 10.6
11 basal cell carcinoma 10.6
12 schimmelpenning-feuerstein-mims syndrome 10.6
13 squamous cell carcinoma 10.3
14 papillary adenoma 10.3
15 verrucous carcinoma 10.3
16 hidrocystoma 10.3
17 eccrine papillary adenoma 10.3
18 teratoma 10.3 ACTC1 GFAP
19 anaplastic ganglioglioma 10.2 ACTC1 GFAP
20 pilocytic astrocytoma 10.2 GFAP KRAS
21 familial isolated dilated cardiomyopathy 10.2 ACTC1 DES
22 gliomatosis peritonei 10.2 DES GFAP
23 malignant ovarian surface epithelial-stromal neoplasm 10.2 KRAS MUC1
24 ovary epithelial cancer 10.2 KRAS MUC1
25 rhabdoid meningioma 10.2 GFAP VIM
26 lymphangiectasis 10.2 ACTC1 VIM
27 alveolar soft part sarcoma 10.2 DES VIM
28 ovarian fibrothecoma 10.2 ACTC1 DES
29 glomangiomyoma 10.2 ACTC1 VIM
30 lymphangioma 10.2 ACTC1 VIM
31 fibroblastic rheumatism 10.2 ACTC1 DES
32 nevus, epidermal 10.2
33 focal dermal hypoplasia 10.2
34 nevus comedonicus 10.2
35 niemann-pick disease 10.2
36 sarcoma 10.2
37 melanoma 10.2
38 sweat gland cancer 10.2
39 cystadenoma 10.2
40 sebaceous adenoma 10.2
41 astrocytoma 10.2
42 grade iii astrocytoma 10.2
43 keratoacanthoma 10.2
44 follicular infundibulum tumor 10.2
45 pulmonary blastoma 10.2 DES KRAS
46 pilomyxoid astrocytoma 10.2 GFAP KRAS
47 liposarcoma 10.2 DES VIM
48 ependymoblastoma 10.2 GFAP VIM
49 astroblastoma 10.2 GFAP VIM
50 intravascular papillary endothelial hyperplasia 10.2 ACTC1 VIM

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to Syringocystadenoma Papilliferum

Symptoms & Phenotypes for Syringocystadenoma Papilliferum

Human phenotypes related to Syringocystadenoma Papilliferum:

60 33
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 60 33 hallmark (90%) Very frequent (99-80%) HP:0001482
2 sparse scalp hair 60 33 hallmark (90%) Very frequent (99-80%) HP:0002209
3 papule 60 33 hallmark (90%) Very frequent (99-80%) HP:0200034
4 abnormal blistering of the skin 60 33 frequent (33%) Frequent (79-30%) HP:0008066
5 nevus sebaceous 60 33 occasional (7.5%) Occasional (29-5%) HP:0010815

MGI Mouse Phenotypes related to Syringocystadenoma Papilliferum:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 ACTC1 DES GFAP KRAS VIM

Drugs & Therapeutics for Syringocystadenoma Papilliferum

Search Clinical Trials , NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

Anatomical Context for Syringocystadenoma Papilliferum

MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

42
Skin, Breast, Cervix

Publications for Syringocystadenoma Papilliferum

Articles related to Syringocystadenoma Papilliferum:

(show top 50) (show all 174)
# Title Authors Year
1
Syringocystadenoma papilliferum of the cervix presenting as vulvar growth in an adolescent girl. ( 30417408 )
2019
2
Dermoscopy of a rare case of linear syringocystadenoma papilliferum with review of the literature. ( 29445572 )
2018
3
Syringocystadenoma papilliferum and trichoblastoma arising in the nevus sebaceous. ( 29567896 )
2018
4
Poromas with large lumens histopathologically mimicking syringocystadenoma papilliferum: Report of three cases. ( 29943807 )
2018
5
Papillary eccrine adenoma associated with syringocystadenoma papilliferum. ( 29582790 )
2018
6
Syringocystadenoma papilliferum with coexisting hydrocystoma. ( 29536975 )
2018
7
Syringocystadenoma papilliferum on the mons pubis. ( 29906013 )
2018
8
Contiguous verrucous proliferations in syringocystadenoma papilliferum: A retrospective analysis with additional evaluation via mutation-specific BRAFV600E immunohistochemistry. ( 29206289 )
2018
9
Simultaneous Presentation of Trichilemmal Carcinoma and Syringocystadenoma Papilliferum within a Nevus Sebaceous. ( 29853758 )
2018
10
Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous. ( 30251370 )
2018
11
Intracytoplasmic eosinophilic inclusion bodies with embryonic folliculosebaceous-apocrine unit differentiation in syringocystadenoma papilliferum. ( 30146780 )
2018
12
Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies. ( 30398985 )
2018
13
Dermoscopy of syringocystadenoma papilliferum. ( 28695704 )
2017
14
Blaschko-linear Syringocystadenoma Papilliferum: A Peculiar Presentation. ( 29204402 )
2017
15
Syringocystadenoma Papilliferum of the External Auditory Canal. ( 28490727 )
2017
16
Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. ( 29166517 )
2017
17
Eyelid syringocystadenoma papilliferum: A novel presentation with major review. ( 29053036 )
2017
18
Squamous cell carcinoma arising from syringocystadenoma papilliferum of the eyelid. ( 29217053 )
2017
19
Syringocystadenoma Papilliferum of Sweat Gland of Caruncle: A Unique Case Report. ( 28936056 )
2017
20
Syringocystadenoma Papilliferum in Coexistence With Verrucous Carcinoma on the Face. ( 29112527 )
2017
21
A Case of Syringocystadenoma Papilliferum with Tubular Papillary Adenoma of the Chest. ( 28502963 )
2017
22
Syringocystadenoma Papilliferum of the Scalp Arising from a Nevus Sebaceous. ( 27761094 )
2016
23
Syringocystadenoma papilliferum of the external auditory canal. Case report and literature review. ( 27658577 )
2016
24
Syringocystadenoma papilliferum with multiple lung metastases and long survival. ( 27837643 )
2016
25
Linear syringocystadenoma papilliferum on the retroauricular area associated with nevus sebaceus. ( 28329571 )
2016
26
Tubulopapillary Cystic Adenoma With Apocrine Differentiation: A Unifying Concept for Syringocystadenoma Papilliferum, Apocrine Gland Cyst, and Tubular Papillary Adenoma. ( 28033156 )
2016
27
Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma, and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus. ( 25761672 )
2015
28
Tricholemmoma, sebaceoma, syringocystadenoma papilliferum, basal cell carcinoma, trichilemmal cyst arising within a nevus sebaceous. ( 26224239 )
2015
29
Eruptive Syringocystadenoma Papilliferum, Keratoacanthoma, and Verruca Vulgaris in a Keratinocytic Epidermal Nevus on the Leg. ( 26790513 )
2015
30
Syringocystadenoma papilliferum arising on naevus sebaceus: A 6-year-old child case described with dermoscopic features. ( 25900640 )
2015
31
Somatic V600E BRAF Mutation in Linear and Sporadic Syringocystadenoma Papilliferum. ( 25950823 )
2015
32
Syringocystadenoma papilliferum of the male nipple. ( 26269194 )
2015
33
Fifteen year natural history of lower eyelid syringocystadenoma papilliferum in a young girl. ( 26097022 )
2015
34
Cytological diagnosis of syringocystadenoma papilliferum a rare adnexal tumor. ( 26229253 )
2015
35
A case of syringocystadenoma papilliferum of eyelid with literature review. ( 26265653 )
2015
36
Multiple pigmented trichoblastomas, sebaceous carcinoma and syringocystadenoma papilliferum arising within a nevus sebaceous. ( 25906325 )
2015
37
Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum. ( 25532942 )
2015
38
Syringocystadenoma papilliferum in an unusual location. ( 26734876 )
2015
39
Basal Cell Carcinoma and Syringocystadenoma Papilliferum Arising in Nevus Sebaceous on Face-A Rare Entity. ( 26677302 )
2015
40
Somatic BRAF c.1799T>A p.V600E Mosaicism syndrome characterized by a linear syringocystadenoma papilliferum, anaplastic astrocytoma, and ocular abnormalities. ( 26360803 )
2015
41
Syringocystadenoma papilliferum of the upper lip. ( 25364565 )
2014
42
Syringocystadenoma papilliferum: an unusual presentation. ( 24995228 )
2014
43
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. ( 24629369 )
2014
44
Linear syringocystadenoma papilliferum on female breast: a rare appendageal tumour on an uncommon location. ( 25756479 )
2014
45
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. ( 23762705 )
2013
46
Follicular hybrid cyst with isthmic-catagen, pilomatrical, and syringocystadenoma papilliferum components. ( 22699865 )
2013
47
A case of syringocystadenoma papilliferum on lower leg: a rare location. ( 24082194 )
2013
48
Linear syringocystadenoma papilliferum: a case report with review of literature. ( 24082219 )
2013
49
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. ( 24021448 )
2013
50
Syringocystadenoma papilliferum arising on the scrotum. ( 22612442 )
2013

Variations for Syringocystadenoma Papilliferum

Expression for Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for Syringocystadenoma Papilliferum

Pathways related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.53 DES GFAP VIM
2
Show member pathways
11.47 GFAP KRAS S100B
3 11.41 ACTC1 DES MUC1 VIM
4 11.23 GFAP S100B VIM
5
Show member pathways
11.02 DES VIM
6 10.99 ACTC1 DES VIM

GO Terms for Syringocystadenoma Papilliferum

Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 ACTC1 DES GFAP KRAS MUC1 S100B
2 focal adhesion GO:0005925 9.43 ACTC1 KRAS VIM
3 intermediate filament cytoskeleton GO:0045111 9.16 DES GFAP
4 intermediate filament GO:0005882 8.8 DES GFAP VIM

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 ACTC1 KRAS VIM
2 cytokine-mediated signaling pathway GO:0019221 9.54 KRAS MUC1 VIM
3 response to glucocorticoid GO:0051384 9.48 KRAS S100B
4 negative regulation of neuron projection development GO:0010977 9.46 GFAP VIM
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.43 KRAS MUC1
6 long-term synaptic potentiation GO:0060291 9.4 GFAP S100B
7 astrocyte development GO:0014002 9.32 GFAP VIM
8 Bergmann glial cell differentiation GO:0060020 9.26 GFAP VIM
9 intermediate filament-based process GO:0045103 9.16 GFAP VIM
10 muscle filament sliding GO:0030049 9.13 ACTC1 DES VIM
11 intermediate filament organization GO:0045109 8.8 DES GFAP VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.26 DES GFAP S100B VIM
2 structural constituent of cytoskeleton GO:0005200 8.8 DES GFAP VIM

Sources for Syringocystadenoma Papilliferum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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