MCID: SYR002
MIFTS: 45

Syringocystadenoma Papilliferum

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Syringocystadenoma Papilliferum

MalaCards integrated aliases for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 12 77 54 60 15 17 74
Fistulous Vegetative Verrucous Hydradenoma 54 60
Naevus Syringocystadenomatosus Papilliferus 60
Syringadenoma Papilliferum 60
Papillary Syringadenoma 12
Papillary Hidradenoma 74
Scap 60

Characteristics:

Orphanet epidemiological data:

60
syringocystadenoma papilliferum
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal;

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:5445
MeSH 45 D000074009
NCIt 51 C4172
SNOMED-CT 69 8934006
ICD10 via Orphanet 35 D23.9
UMLS via Orphanet 75 C0406803
Orphanet 60 ORPHA840

Summaries for Syringocystadenoma Papilliferum

MalaCards based summary : Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to apocrine adenoma and hidradenoma. An important gene associated with Syringocystadenoma Papilliferum is DES (Desmin), and among its related pathways/superpathways are ERK Signaling and Development EGFR signaling pathway. Affiliated tissues include skin, cervix and brain, and related phenotypes are subcutaneous nodule and sparse scalp hair

Wikipedia : 77 Syringocystadenoma papilliferum is a benign apocrine... more...

Related Diseases for Syringocystadenoma Papilliferum

Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
# Related Disease Score Top Affiliating Genes
1 apocrine adenoma 31.3 KRAS MUC1
2 hidradenoma 30.6 MUC1 VIM
3 cutaneous leiomyosarcoma 30.2 DES GFAP MUC1
4 adenosquamous carcinoma 30.0 KRAS MUC1
5 leiomyosarcoma 29.9 DES S100B VIM
6 sarcoma 29.9 BRAF KRAS VIM
7 syringoma 29.4 DES GFAP MUC1 S100B VIM
8 dystonia, dopa-responsive, due to sepiapterin reductase deficiency 11.3
9 hypercholesterolemia, familial 11.1
10 adenoma 10.8
11 basal cell carcinoma 1 10.6
12 basal cell carcinoma 10.6
13 schimmelpenning-feuerstein-mims syndrome 10.6
14 squamous cell carcinoma 10.4
15 papillary adenoma 10.3
16 verrucous carcinoma 10.3
17 hidrocystoma 10.3
18 sebaceous adenocarcinoma 10.3
19 eccrine acrospiroma 10.3
20 eccrine papillary adenoma 10.3
21 gliomatosis peritonei 10.3 DES GFAP
22 neuronal ceroid-lipofuscinoses 10.2 GFAP S100B
23 papillary ependymoma 10.2 GFAP S100B
24 malignant triton tumor 10.2 DES S100B
25 pulmonary blastoma 10.2 DES KRAS
26 myxofibrosarcoma 10.2 DES S100B
27 leukemia, chronic lymphocytic 2 10.2 BRAF KRAS
28 non-langerhans-cell histiocytosis 10.2 BRAF DES
29 gemistocytic astrocytoma 10.2 GFAP S100B
30 medullomyoblastoma 10.2 DES GFAP
31 dysembryoplastic neuroepithelial tumor 10.2 GFAP S100B
32 urachal adenocarcinoma 10.2 BRAF KRAS
33 pineocytoma 10.2 GFAP S100B
34 nevus, epidermal 10.2
35 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2
36 focal dermal hypoplasia 10.2
37 nevus comedonicus 10.2
38 niemann-pick disease 10.2
39 melanoma 10.2
40 sweat gland cancer 10.2
41 cystadenoma 10.2
42 sebaceous adenoma 10.2
43 astrocytoma 10.2
44 grade iii astrocytoma 10.2
45 keratoacanthoma 10.2
46 follicular infundibulum tumor 10.2
47 hyperplastic polyposis syndrome 10.2 BRAF KRAS
48 spindle cell thymoma 10.2 DES MUC1
49 pleomorphic xanthoastrocytoma 10.2 BRAF GFAP
50 mature teratoma 10.2 BRAF KRAS

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to Syringocystadenoma Papilliferum

Symptoms & Phenotypes for Syringocystadenoma Papilliferum

Human phenotypes related to Syringocystadenoma Papilliferum:

60 33
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 60 33 hallmark (90%) Very frequent (99-80%) HP:0001482
2 sparse scalp hair 60 33 hallmark (90%) Very frequent (99-80%) HP:0002209
3 papule 60 33 hallmark (90%) Very frequent (99-80%) HP:0200034
4 abnormal blistering of the skin 60 33 frequent (33%) Frequent (79-30%) HP:0008066
5 nevus sebaceous 60 33 occasional (7.5%) Occasional (29-5%) HP:0010815

GenomeRNAi Phenotypes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 BRAF KRAS MUC1
2 Decreased viability GR00106-A-0 9.47 KRAS
3 Decreased viability GR00221-A-1 9.47 KRAS
4 Decreased viability GR00221-A-2 9.47 KRAS
5 Decreased viability GR00221-A-4 9.47 BRAF
6 Decreased viability GR00301-A 9.47 BRAF KRAS
7 Decreased viability GR00381-A-1 9.47 BRAF KRAS
8 Decreased viability GR00402-S-2 9.47 BRAF KRAS MUC1
9 Decreased cell migration GR00055-A-1 9.26 BRAF KRAS MUC1 VIM

MGI Mouse Phenotypes related to Syringocystadenoma Papilliferum:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 BRAF DES GFAP KRAS S100B VIM
2 muscle MP:0005369 9.02 BRAF DES GFAP KRAS VIM

Drugs & Therapeutics for Syringocystadenoma Papilliferum

Search Clinical Trials , NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

Anatomical Context for Syringocystadenoma Papilliferum

MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

42
Skin, Cervix, Brain, Pituitary, Colon, Eye, Smooth Muscle

Publications for Syringocystadenoma Papilliferum

Articles related to Syringocystadenoma Papilliferum:

(show top 50) (show all 177)
# Title Authors Year
1
Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous. ( 30251370 )
2019
2
Well-differentiated Squamous Cell Carcinoma Arising in Syringocystadenoma Papilliferum. ( 30984594 )
2019
3
Syringocystadenoma papilliferum with coexisting hydrocystoma. ( 29536975 )
2019
4
Poromas with large lumens histopathologically mimicking syringocystadenoma papilliferum: Report of three cases. ( 29943807 )
2019
5
Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies. ( 30398985 )
2019
6
Syringocystadenoma papilliferum of the cervix presenting as vulvar growth in an adolescent girl. ( 30417408 )
2019
7
Reflectance confocal microscopic findings of a tiny syringocystadenoma papilliferum. ( 30989100 )
2019
8
Syringocystadenoma papilliferum arising in a naevus sebaceous. ( 31025637 )
2019
9
Papillary eccrine adenoma associated with syringocystadenoma papilliferum. ( 29582790 )
2018
10
Dermoscopy of syringocystadenoma papilliferum. ( 28695704 )
2018
11
Eyelid syringocystadenoma papilliferum: A novel presentation with major review. ( 29053036 )
2018
12
Syringocystadenoma Papilliferum in Coexistence With Verrucous Carcinoma on the Face. ( 29112527 )
2018
13
Contiguous verrucous proliferations in syringocystadenoma papilliferum: A retrospective analysis with additional evaluation via mutation-specific BRAFV600E immunohistochemistry. ( 29206289 )
2018
14
Dermoscopy of a rare case of linear syringocystadenoma papilliferum with review of the literature. ( 29445572 )
2018
15
Syringocystadenoma papilliferum and trichoblastoma arising in the nevus sebaceous. ( 29567896 )
2018
16
Simultaneous Presentation of Trichilemmal Carcinoma and Syringocystadenoma Papilliferum within a Nevus Sebaceous. ( 29853758 )
2018
17
Syringocystadenoma papilliferum on the mons pubis. ( 29906013 )
2018
18
Intracytoplasmic eosinophilic inclusion bodies with embryonic folliculosebaceous-apocrine unit differentiation in syringocystadenoma papilliferum. ( 30146780 )
2018
19
Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. ( 29166517 )
2017
20
A Case of Syringocystadenoma Papilliferum with Tubular Papillary Adenoma of the Chest. ( 28502963 )
2017
21
Tubulopapillary Cystic Adenoma With Apocrine Differentiation: A Unifying Concept for Syringocystadenoma Papilliferum, Apocrine Gland Cyst, and Tubular Papillary Adenoma. ( 28033156 )
2017
22
Syringocystadenoma papilliferum of the external auditory canal. Case report and literature review. ( 27658577 )
2017
23
Syringocystadenoma Papilliferum of the External Auditory Canal. ( 28490727 )
2017
24
Syringocystadenoma Papilliferum of Sweat Gland of Caruncle: A Unique Case Report. ( 28936056 )
2017
25
Blaschko-linear Syringocystadenoma Papilliferum: A Peculiar Presentation. ( 29204402 )
2017
26
Squamous cell carcinoma arising from syringocystadenoma papilliferum of the eyelid. ( 29217053 )
2017
27
Somatic BRAF c.1799T>A p.V600E Mosaicism syndrome characterized by a linear syringocystadenoma papilliferum, anaplastic astrocytoma, and ocular abnormalities. ( 26360803 )
2016
28
Syringocystadenoma papilliferum of the male nipple. ( 26269194 )
2016
29
Syringocystadenoma Papilliferum of the Scalp Arising from a Nevus Sebaceous. ( 27761094 )
2016
30
Syringocystadenoma papilliferum with multiple lung metastases and long survival. ( 27837643 )
2016
31
Linear syringocystadenoma papilliferum on the retroauricular area associated with nevus sebaceus. ( 28329571 )
2016
32
Tricholemmoma, sebaceoma, syringocystadenoma papilliferum, basal cell carcinoma, trichilemmal cyst arising within a nevus sebaceous. ( 26224239 )
2015
33
Basal Cell Carcinoma and Syringocystadenoma Papilliferum Arising in Nevus Sebaceous on Face-A Rare Entity. ( 26677302 )
2015
34
Eruptive Syringocystadenoma Papilliferum, Keratoacanthoma, and Verruca Vulgaris in a Keratinocytic Epidermal Nevus on the Leg. ( 26790513 )
2015
35
Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum. ( 25532942 )
2015
36
Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus. ( 25761672 )
2015
37
Syringocystadenoma papilliferum arising on naevus sebaceus: A 6-year-old child case described with dermoscopic features. ( 25900640 )
2015
38
Multiple pigmented trichoblastomas, sebaceous carcinoma and syringocystadenoma papilliferum arising within a nevus sebaceous. ( 25906325 )
2015
39
Somatic V600E BRAF Mutation in Linear and Sporadic Syringocystadenoma Papilliferum. ( 25950823 )
2015
40
Fifteen year natural history of lower eyelid syringocystadenoma papilliferum in a young girl. ( 26097022 )
2015
41
Cytological diagnosis of syringocystadenoma papilliferum a rare adnexal tumor. ( 26229253 )
2015
42
A case of syringocystadenoma papilliferum of eyelid with literature review. ( 26265653 )
2015
43
Syringocystadenoma papilliferum in an unusual location. ( 26734876 )
2015
44
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. ( 24629369 )
2014
45
Syringocystadenoma papilliferum: an unusual presentation. ( 24995228 )
2014
46
Syringocystadenoma papilliferum of the upper lip. ( 25364565 )
2014
47
Linear syringocystadenoma papilliferum on female breast: a rare appendageal tumour on an uncommon location. ( 25756479 )
2014
48
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. ( 23762705 )
2013
49
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. ( 24021448 )
2013
50
A case of syringocystadenoma papilliferum on lower leg: a rare location. ( 24082194 )
2013

Variations for Syringocystadenoma Papilliferum

Expression for Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for Syringocystadenoma Papilliferum

GO Terms for Syringocystadenoma Papilliferum

Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 BRAF DES GFAP KRAS MUC1 S100B
2 intermediate filament cytoskeleton GO:0045111 9.16 DES GFAP
3 intermediate filament GO:0005882 8.8 DES GFAP VIM

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.58 KRAS MUC1 VIM
2 visual learning GO:0008542 9.43 BRAF KRAS
3 muscle filament sliding GO:0030049 9.37 DES VIM
4 astrocyte development GO:0014002 9.32 GFAP VIM
5 Bergmann glial cell differentiation GO:0060020 9.26 GFAP VIM
6 intermediate filament-based process GO:0045103 9.16 GFAP VIM
7 long-term synaptic potentiation GO:0060291 9.13 BRAF GFAP S100B
8 intermediate filament organization GO:0045109 8.8 DES GFAP VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 BRAF DES GFAP S100B VIM
2 structural constituent of cytoskeleton GO:0005200 8.8 DES GFAP VIM

Sources for Syringocystadenoma Papilliferum

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35 ICD10 via Orphanet
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63 PubMed
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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
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75 UMLS via Orphanet
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