SCAP
MCID: SYR002
MIFTS: 46

Syringocystadenoma Papilliferum (SCAP)

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Syringocystadenoma Papilliferum

MalaCards integrated aliases for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 12 76 53 59 15 73
Fistulous Vegetative Verrucous Hydradenoma 53 59
Naevus Syringocystadenomatosus Papilliferus 59
Syringadenoma Papilliferum 59
Papillary Syringadenoma 12
Papillary Hidradenoma 73
Scap 59

Characteristics:

Orphanet epidemiological data:

59
syringocystadenoma papilliferum
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:5445
MeSH 44 D000074009
NCIt 50 C4172
SNOMED-CT 68 8934006
Orphanet 59 ORPHA840
UMLS via Orphanet 74 C0406803
ICD10 via Orphanet 34 D23.9

Summaries for Syringocystadenoma Papilliferum

MalaCards based summary : Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to apocrine adenoma and hidradenoma. An important gene associated with Syringocystadenoma Papilliferum is DES (Desmin), and among its related pathways/superpathways are ERK Signaling and Development EGFR signaling pathway. Affiliated tissues include skin, cervix and brain, and related phenotypes are subcutaneous nodule and abnormal blistering of the skin

Wikipedia : 76 Syringocystadenoma papilliferum (also known as "syringadenoma papilliferum") is a benign apocrine... more...

Related Diseases for Syringocystadenoma Papilliferum

Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 apocrine adenoma 31.2 KRAS MUC1
2 hidradenoma 30.8 MUC1 VIM
3 cutaneous leiomyosarcoma 30.2 DES GFAP VIM
4 leiomyosarcoma 30.0 DES S100B VIM
5 adenosquamous carcinoma 29.9 KRAS MUC1
6 syringoma 29.8 DES GFAP MUC1 S100B VIM
7 dystonia, dopa-responsive, due to sepiapterin reductase deficiency 11.2
8 hypercholesterolemia, familial 11.1
9 adenoma 10.8
10 basal cell carcinoma 1 10.6
11 basal cell carcinoma 10.6
12 schimmelpenning-feuerstein-mims syndrome 10.5
13 squamous cell carcinoma 10.3
14 papillary adenoma 10.3
15 verrucous carcinoma 10.3
16 hidrocystoma 10.3
17 eccrine papillary adenoma 10.3
18 gliomatosis peritonei 10.2 DES GFAP
19 alveolar soft part sarcoma 10.2 DES VIM
20 pulmonary blastoma 10.2 DES KRAS
21 leukemia, chronic lymphocytic 2 10.2 BRAF KRAS
22 nevus, epidermal 10.2
23 focal dermal hypoplasia 10.2
24 nevus comedonicus 10.2
25 niemann-pick disease 10.2
26 sarcoma 10.2
27 melanoma 10.2
28 cystadenoma 10.2
29 sebaceous adenoma 10.2
30 astrocytoma 10.2
31 grade iii astrocytoma 10.2
32 keratoacanthoma 10.2
33 follicular infundibulum tumor 10.2
34 infantile digital fibromatosis 10.2 DES VIM
35 fibromatosis 10.2 DES VIM
36 lymphangiomatosis 10.2 DES VIM
37 angiolipoma 10.1 DES VIM
38 spindle cell lipoma 10.1 DES VIM
39 epulis 10.1 DES VIM
40 epithelioid leiomyosarcoma 10.1 DES VIM
41 benign metastasizing leiomyoma 10.1 DES VIM
42 non-langerhans-cell histiocytosis 10.1 BRAF DES
43 urachal adenocarcinoma 10.1 BRAF KRAS
44 cystic nephroma 10.1 DES VIM
45 neuroblastoma 10.1
46 hyperplastic polyposis syndrome 10.1 BRAF KRAS
47 congenital fibrosarcoma 10.1 DES VIM
48 pseudosarcomatous fibromatosis 10.1 DES VIM
49 mature teratoma 10.1 BRAF KRAS
50 glomus tumor 10.1 DES VIM

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to Syringocystadenoma Papilliferum

Symptoms & Phenotypes for Syringocystadenoma Papilliferum

Human phenotypes related to Syringocystadenoma Papilliferum:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001482
2 abnormal blistering of the skin 59 32 frequent (33%) Frequent (79-30%) HP:0008066
3 sparse scalp hair 59 32 hallmark (90%) Very frequent (99-80%) HP:0002209
4 papule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200034
5 nevus sebaceous 59 32 occasional (7.5%) Occasional (29-5%) HP:0010815

GenomeRNAi Phenotypes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 BRAF KRAS MUC1
2 Decreased viability GR00106-A-0 9.47 KRAS
3 Decreased viability GR00221-A-1 9.47 KRAS
4 Decreased viability GR00221-A-2 9.47 KRAS
5 Decreased viability GR00221-A-4 9.47 BRAF
6 Decreased viability GR00301-A 9.47 BRAF KRAS
7 Decreased viability GR00381-A-1 9.47 BRAF KRAS
8 Decreased viability GR00402-S-2 9.47 BRAF KRAS MUC1
9 Decreased cell migration GR00055-A-1 9.26 BRAF KRAS MUC1 VIM

MGI Mouse Phenotypes related to Syringocystadenoma Papilliferum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 BRAF DES GFAP KRAS S100B VIM
2 muscle MP:0005369 9.02 BRAF DES GFAP KRAS VIM

Drugs & Therapeutics for Syringocystadenoma Papilliferum

Search Clinical Trials , NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

Anatomical Context for Syringocystadenoma Papilliferum

MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

41
Skin, Cervix, Brain, Liver, Ovary, Pituitary, Smooth Muscle

Publications for Syringocystadenoma Papilliferum

Articles related to Syringocystadenoma Papilliferum:

(show top 50) (show all 174)
# Title Authors Year
1
Syringocystadenoma papilliferum of the cervix presenting as vulvar growth in an adolescent girl. ( 30417408 )
2019
2
Dermoscopy of a rare case of linear syringocystadenoma papilliferum with review of the literature. ( 29445572 )
2018
3
Syringocystadenoma papilliferum and trichoblastoma arising in the nevus sebaceous. ( 29567896 )
2018
4
Poromas with large lumens histopathologically mimicking syringocystadenoma papilliferum: Report of three cases. ( 29943807 )
2018
5
Papillary eccrine adenoma associated with syringocystadenoma papilliferum. ( 29582790 )
2018
6
Syringocystadenoma papilliferum with coexisting hydrocystoma. ( 29536975 )
2018
7
Syringocystadenoma papilliferum on the mons pubis. ( 29906013 )
2018
8
Contiguous verrucous proliferations in syringocystadenoma papilliferum: A retrospective analysis with additional evaluation via mutation-specific BRAFV600E immunohistochemistry. ( 29206289 )
2018
9
Simultaneous Presentation of Trichilemmal Carcinoma and Syringocystadenoma Papilliferum within a Nevus Sebaceous. ( 29853758 )
2018
10
Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous. ( 30251370 )
2018
11
Intracytoplasmic eosinophilic inclusion bodies with embryonic folliculosebaceous-apocrine unit differentiation in syringocystadenoma papilliferum. ( 30146780 )
2018
12
Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies. ( 30398985 )
2018
13
Dermoscopy of syringocystadenoma papilliferum. ( 28695704 )
2017
14
Blaschko-linear Syringocystadenoma Papilliferum: A Peculiar Presentation. ( 29204402 )
2017
15
Syringocystadenoma Papilliferum of the External Auditory Canal. ( 28490727 )
2017
16
Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. ( 29166517 )
2017
17
Eyelid syringocystadenoma papilliferum: A novel presentation with major review. ( 29053036 )
2017
18
Squamous cell carcinoma arising from syringocystadenoma papilliferum of the eyelid. ( 29217053 )
2017
19
Syringocystadenoma Papilliferum of Sweat Gland of Caruncle: A Unique Case Report. ( 28936056 )
2017
20
Syringocystadenoma Papilliferum in Coexistence With Verrucous Carcinoma on the Face. ( 29112527 )
2017
21
A Case of Syringocystadenoma Papilliferum with Tubular Papillary Adenoma of the Chest. ( 28502963 )
2017
22
Tubulopapillary Cystic Adenoma With Apocrine Differentiation: A Unifying Concept for Syringocystadenoma Papilliferum, Apocrine Gland Cyst, and Tubular Papillary Adenoma. ( 28033156 )
2017
23
Syringocystadenoma Papilliferum of the Scalp Arising from a Nevus Sebaceous. ( 27761094 )
2016
24
Syringocystadenoma papilliferum of the external auditory canal. Case report and literature review. ( 27658577 )
2016
25
Syringocystadenoma papilliferum with multiple lung metastases and long survival. ( 27837643 )
2016
26
Somatic BRAF c.1799T>A p.V600E Mosaicism syndrome characterized by a linear syringocystadenoma papilliferum, anaplastic astrocytoma, and ocular abnormalities. ( 26360803 )
2016
27
Linear syringocystadenoma papilliferum on the retroauricular area associated with nevus sebaceus. ( 28329571 )
2016
28
Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma, and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus. ( 25761672 )
2015
29
Tricholemmoma, sebaceoma, syringocystadenoma papilliferum, basal cell carcinoma, trichilemmal cyst arising within a nevus sebaceous. ( 26224239 )
2015
30
Eruptive Syringocystadenoma Papilliferum, Keratoacanthoma, and Verruca Vulgaris in a Keratinocytic Epidermal Nevus on the Leg. ( 26790513 )
2015
31
Syringocystadenoma papilliferum arising on naevus sebaceus: A 6-year-old child case described with dermoscopic features. ( 25900640 )
2015
32
Somatic V600E BRAF Mutation in Linear and Sporadic Syringocystadenoma Papilliferum. ( 25950823 )
2015
33
Syringocystadenoma papilliferum of the male nipple. ( 26269194 )
2015
34
Fifteen year natural history of lower eyelid syringocystadenoma papilliferum in a young girl. ( 26097022 )
2015
35
Cytological diagnosis of syringocystadenoma papilliferum a rare adnexal tumor. ( 26229253 )
2015
36
A case of syringocystadenoma papilliferum of eyelid with literature review. ( 26265653 )
2015
37
Multiple pigmented trichoblastomas, sebaceous carcinoma and syringocystadenoma papilliferum arising within a nevus sebaceous. ( 25906325 )
2015
38
Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum. ( 25532942 )
2015
39
Syringocystadenoma papilliferum in an unusual location. ( 26734876 )
2015
40
Basal Cell Carcinoma and Syringocystadenoma Papilliferum Arising in Nevus Sebaceous on Face-A Rare Entity. ( 26677302 )
2015
41
Syringocystadenoma papilliferum of the upper lip. ( 25364565 )
2014
42
Syringocystadenoma papilliferum: an unusual presentation. ( 24995228 )
2014
43
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. ( 24629369 )
2014
44
Linear syringocystadenoma papilliferum on female breast: a rare appendageal tumour on an uncommon location. ( 25756479 )
2014
45
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. ( 23762705 )
2013
46
Follicular hybrid cyst with isthmic-catagen, pilomatrical, and syringocystadenoma papilliferum components. ( 22699865 )
2013
47
A case of syringocystadenoma papilliferum on lower leg: a rare location. ( 24082194 )
2013
48
Linear syringocystadenoma papilliferum: a case report with review of literature. ( 24082219 )
2013
49
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. ( 24021448 )
2013
50
Syringocystadenoma papilliferum arising on the scrotum. ( 22612442 )
2013

Variations for Syringocystadenoma Papilliferum

Expression for Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for Syringocystadenoma Papilliferum

GO Terms for Syringocystadenoma Papilliferum

Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 BRAF DES GFAP KRAS MUC1 S100B
2 intermediate filament cytoskeleton GO:0045111 9.16 DES GFAP
3 intermediate filament GO:0005882 8.8 DES GFAP VIM

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.58 KRAS MUC1 VIM
2 visual learning GO:0008542 9.43 BRAF KRAS
3 muscle filament sliding GO:0030049 9.37 DES VIM
4 astrocyte development GO:0014002 9.32 GFAP VIM
5 Bergmann glial cell differentiation GO:0060020 9.26 GFAP VIM
6 intermediate filament-based process GO:0045103 9.16 GFAP VIM
7 long-term synaptic potentiation GO:0060291 9.13 BRAF GFAP S100B
8 intermediate filament organization GO:0045109 8.8 DES GFAP VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 BRAF DES GFAP S100B VIM
2 structural constituent of cytoskeleton GO:0005200 8.8 DES GFAP VIM

Sources for Syringocystadenoma Papilliferum

3 CDC
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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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45 MESH via Orphanet
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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