SCAP
MCID: SYR002
MIFTS: 44

Syringocystadenoma Papilliferum (SCAP)

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Syringocystadenoma Papilliferum

MalaCards integrated aliases for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 12 73 20 58 15 17 70
Fistulous Vegetative Verrucous Hydradenoma 20 58
Naevus Syringocystadenomatosus Papilliferus 58
Papillary Syringocystadenoma 58
Syringadenoma Papilliferum 58
Papillary Syringadenoma 12
Papillary Hidradenoma 70
Scap 58

Characteristics:

Orphanet epidemiological data:

58
syringocystadenoma papilliferum
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:5445
MeSH 44 D000074009
NCIt 50 C4172
SNOMED-CT 67 8934006
ICD10 via Orphanet 33 D23.9
UMLS via Orphanet 71 C0406803
Orphanet 58 ORPHA840
UMLS 70 C0334348 C0406803

Summaries for Syringocystadenoma Papilliferum

MalaCards based summary : Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to apocrine adenoma and rare tumor. An important gene associated with Syringocystadenoma Papilliferum is KRT19 (Keratin 19), and among its related pathways/superpathways are Development ERBB-family signaling and Signaling by ERBB4. The drugs Immunoglobulin M and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin, smooth muscle and salivary gland, and related phenotypes are subcutaneous nodule and sparse scalp hair

Wikipedia : 73 Syringocystadenoma papilliferum is a benign apocrine... more...

Related Diseases for Syringocystadenoma Papilliferum

Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 377)
# Related Disease Score Top Affiliating Genes
1 apocrine adenoma 31.3 KRAS BRAF
2 rare tumor 30.8 DES ACTC1
3 hidradenoma 30.8 VIM MUC1
4 eccrine papillary adenoma 30.7 KRT19 KRAS
5 pyogenic granuloma 30.4 KRAS ACTC1
6 apocrine adenocarcinoma 30.4 SERPINA3 MUC1
7 papillary adenoma 30.2 VIM KRAS
8 adenosquamous carcinoma 29.8 SERPINA3 MUC1 KRT19 KRAS
9 syringoma 29.2 VIM S100B MUC1 KRT19 GFAP DES
10 hydrocephalus 29.1 SERPINA3 S100B GFAP
11 malignant astrocytoma 28.9 VIM SERPINA3 S100B GFAP BRAF
12 cutaneous leiomyosarcoma 28.8 VIM S100B MUC1 GFAP DES ACTC1
13 pleomorphic adenoma 28.8 VIM S100B MUC1 GFAP DES ACTC1
14 sarcoma 28.7 VIM S100B MUC1 KRAS BRAF ACTC1
15 leiomyosarcoma 28.7 VIM SERPINA3 S100B MUC1 DES ACTC1
16 spindle cell sarcoma 28.7 VIM SERPINA3 S100B MUC1 DES ACTC1
17 prostate cancer 11.2
18 lipid metabolism disorder 11.1
19 hypercholesterolemia, familial, 1 10.9
20 c syndrome 10.9
21 mckusick-kaufman syndrome 10.9
22 niemann-pick disease, type c1 10.9
23 dystonia, dopa-responsive, due to sepiapterin reductase deficiency 10.9
24 malt worker's lung 10.9
25 adenoma 10.7
26 basal cell carcinoma 10.7
27 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.6
28 schimmelpenning-feuerstein-mims syndrome 10.6
29 papilloma 10.5
30 hidrocystoma 10.5
31 cystadenoma 10.4
32 verrucous carcinoma 10.4
33 eccrine acrospiroma 10.4
34 keratosis 10.4
35 squamous cell papilloma 10.3
36 squamous cell carcinoma 10.3
37 mucinous tubular and spindle renal cell carcinoma 10.3 MUC1 KRT19
38 limbal stem cell deficiency 10.3 MUC1 KRT19
39 mixed fibrolamellar hepatocellular carcinoma 10.3 MUC1 KRT19
40 tall cell variant papillary carcinoma 10.3 KRT19 BRAF
41 cholangiolocellular carcinoma 10.3 MUC1 KRT19
42 epithelioid trophoblastic tumor 10.3 MUC1 ACTC1
43 spindle cell thymoma 10.3 MUC1 DES
44 fibroblastic rheumatism 10.3 DES ACTC1
45 ovarian fibrothecoma 10.2 DES ACTC1
46 benign peritoneal mesothelioma 10.2 MUC1 KRT19
47 sebaceous adenocarcinoma 10.2
48 adult cystic nephroma 10.2 DES ACTC1
49 pulmonary vein stenosis 10.2 DES ACTC1
50 anaplastic ganglioglioma 10.2 GFAP ACTC1

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to Syringocystadenoma Papilliferum

Symptoms & Phenotypes for Syringocystadenoma Papilliferum

Human phenotypes related to Syringocystadenoma Papilliferum:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482
2 sparse scalp hair 58 31 hallmark (90%) Very frequent (99-80%) HP:0002209
3 papule 58 31 hallmark (90%) Very frequent (99-80%) HP:0200034
4 abnormal blistering of the skin 58 31 frequent (33%) Frequent (79-30%) HP:0008066
5 nevus sebaceous 58 31 occasional (7.5%) Occasional (29-5%) HP:0010815

GenomeRNAi Phenotypes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

26 (show all 26)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.89 BRAF KRAS MUC1
2 Decreased viability GR00055-A-2 9.89 BRAF KRAS MUC1
3 Decreased viability GR00055-A-3 9.89 KRAS
4 Decreased viability GR00106-A-0 9.89 KRAS
5 Decreased viability GR00221-A-1 9.89 KRAS
6 Decreased viability GR00221-A-2 9.89 KRAS
7 Decreased viability GR00221-A-4 9.89 BRAF
8 Decreased viability GR00249-S 9.89 BRAF MUC1
9 Decreased viability GR00301-A 9.89 BRAF KRAS
10 Decreased viability GR00381-A-1 9.89 BRAF KRAS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.53 KRAS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.53 KRT19
14 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.53 BRAF
15 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.53 KRT19
16 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.53 KRT19 VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.53 VIM
18 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.53 KRAS
19 Increased shRNA abundance (Z-score > 2) GR00366-A-34 9.53 KRT19
20 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.53 KRT19
21 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.53 BRAF
22 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.53 KRAS VIM
23 Increased shRNA abundance (Z-score > 2) GR00366-A-75 9.53 KRT19
24 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.53 KRT19
25 Decreased cell migration GR00055-A-1 9.16 VIM
26 Decreased cell migration GR00055-A-3 9.16 BRAF

MGI Mouse Phenotypes related to Syringocystadenoma Papilliferum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ACTC1 BRAF DES GFAP KRAS KRT19
2 muscle MP:0005369 9.43 ACTC1 BRAF DES GFAP KRAS VIM
3 normal MP:0002873 9.17 ACTC1 BRAF GFAP KRAS KRT19 S100B

Drugs & Therapeutics for Syringocystadenoma Papilliferum

Drugs for Syringocystadenoma Papilliferum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulin M Phase 2
2 Antibodies Phase 2
3 Immunoglobulins, Intravenous Phase 2
4 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group, Adaptive Group-sequential Phase II Study, to Determine the Efficacy and Safety of BT086 as an Adjunctive Treatment in Severe Community Acquired Pneumonia (sCAP) Completed NCT01420744 Phase 2 BT086;1% Human Albumin infusion
2 Diagnostic Strategy Evaluation Study of Two Diagnostic Strategies for the Treatment of SCAP : Noninvasive Strategy and Semiinvasive Strategy Including FOB Distal Samplings Unknown status NCT00308659
3 Prospective Study to Discover New Biomarkers for Early Detection of Sepsis and Prediction of Sepsis-related Mortality in Patients With Severe Community Acquired Pneumonia (sCAP) Not yet recruiting NCT04280354

Search NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

Anatomical Context for Syringocystadenoma Papilliferum

MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

40
Skin, Smooth Muscle, Salivary Gland, Cervix

Publications for Syringocystadenoma Papilliferum

Articles related to Syringocystadenoma Papilliferum:

(show top 50) (show all 318)
# Title Authors PMID Year
1
Sialadenoma Papilliferum. 61
33526222 2021
2
Rare combination of verrucous carcinoma and syringocystadenoma papilliferum in anterior perineal sinus: recognizing the absence of normality. 61
33792154 2021
3
Dermoscopic findings of de novo syringocystadenoma papilliferum. 61
33769726 2021
4
Syringocystadenoma Papilliferum Arising in an Anophthalmic Socket. 61
33710039 2021
5
A rare case of pediatric linear syringocystadenoma papilliferum of the chest. 61
33438854 2021
6
A Rare Case of Porocarcinoma and Trichoblastoma Arising in a Nevus Sebaceus of Jadassohn. 61
33763265 2021
7
Four pediatric cases of secondary neoplasms arising in nevus sebaceous. 61
32495466 2020
8
Salivary Sialadenoma Papilliferum Consists of Two Morphologically, Immunophenotypically, and Genetically Distinct Subtypes. 61
31473937 2020
9
Unusual congenital syringocystadenoma papilliferum on the scalp presenting as only erosion at birth. 61
32538363 2020
10
Hidradenoma Papilliferum: Everyone Else's Diagnosis. 61
32180606 2020
11
Solitary syringocystadenoma papilliferum on the face: A rare case report with dermoscopic findings. 61
31573674 2020
12
Nevus sebaceus with syringocystadenoma papilliferum, prurigo nodularis, apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma: case report and review of nevus sebaceus-associated conditions. 61
32239888 2020
13
Syringocystadenoma papilliferum associated with verrucous carcinoma of the skin in the same lesion: Report of four cases. 61
31449665 2020
14
[Syringocystadenoma papilliferum]. 61
31732362 2019
15
Grouped apocrine gland component associated with sporadic syringocystadenoma papilliferum: A case report and BRAFV600E mutation analysis of the two components. 61
31294472 2019
16
[Anatomoclinical and immunohistochemical study of hidradenoma papilliferum, a tumor deriving from anogenital mammary-like glands]. 61
31285043 2019
17
Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous. 61
30251370 2019
18
Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies. 61
30398985 2019
19
Reflectance confocal microscopic findings of a tiny syringocystadenoma papilliferum. 61
30989100 2019
20
Syringocystadenoma papilliferum arising in a naevus sebaceous. 61
31025637 2019
21
Well-differentiated Squamous Cell Carcinoma Arising in Syringocystadenoma Papilliferum. 61
30984594 2019
22
Syringocystadenoma papilliferum with coexisting hydrocystoma. 61
29536975 2019
23
Poromas with large lumens histopathologically mimicking syringocystadenoma papilliferum: Report of three cases. 61
29943807 2019
24
Syringocystadenoma papilliferum of the cervix presenting as vulvar growth in an adolescent girl. 61
30417408 2019
25
Syringocystadenoma Papilliferum: A Case Report and Review of the Literature. 61
32355486 2019
26
[Epidemiological and anatomoclinical features of scalp tumors in black Africans]. 61
31934241 2019
27
Is Syringocystadenoma Papilliferum Incidental in This Verrucous Carcinoma? 61
31772805 2019
28
Intracytoplasmic eosinophilic inclusion bodies with embryonic folliculosebaceous-apocrine unit differentiation in syringocystadenoma papilliferum. 61
30146780 2018
29
Primary cutaneous apocrine carcinoma arising within a nevus sebaceus. 61
30489554 2018
30
Syringocystadenoma Papilliferum in Coexistence With Verrucous Carcinoma on the Face. 61
29112527 2018
31
Eyelid syringocystadenoma papilliferum: A novel presentation with major review. 61
29053036 2018
32
Simultaneous Presentation of Trichilemmal Carcinoma and Syringocystadenoma Papilliferum within a Nevus Sebaceous. 61
29853758 2018
33
Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature. 61
28887760 2018
34
Papillary eccrine adenoma associated with syringocystadenoma papilliferum. 61
29582790 2018
35
Syringocystadenoma papilliferum on the mons pubis. 61
29906013 2018
36
Contiguous verrucous proliferations in syringocystadenoma papilliferum: A retrospective analysis with additional evaluation via mutation-specific BRAFV600E immunohistochemistry. 61
29206289 2018
37
Dermoscopy of syringocystadenoma papilliferum. 61
28695704 2018
38
A Case of Phacomatosis Pigmentokeratotica Associated With Multiple Basal Cell Carcinomas. 61
28937433 2018
39
Dermoscopy of a rare case of linear syringocystadenoma papilliferum with review of the literature. 61
29445572 2018
40
Syringocystadenoma papilliferum and trichoblastoma arising in the nevus sebaceous. 61
29567896 2018
41
Squamous cell carcinoma arising from syringocystadenoma papilliferum of the eyelid. 61
29217053 2017
42
Tubulopapillary Cystic Adenoma With Apocrine Differentiation: A Unifying Concept for Syringocystadenoma Papilliferum, Apocrine Gland Cyst, and Tubular Papillary Adenoma. 61
28033156 2017
43
Rare desmoplastic trichilemmoma associated with sebaceous nevus. 61
29364442 2017
44
Blaschko-linear Syringocystadenoma Papilliferum: A Peculiar Presentation. 61
29204402 2017
45
Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. 61
29166517 2017
46
Syringocystadenoma papilliferum of the external auditory canal. Case report and literature review. 61
27658577 2017
47
Pigmented Trichoblastoma of Nose: An Unusual Occurrence. 61
28892945 2017
48
SOX10 immunohistochemistry in sweat ductal/glandular neoplasms. 61
28343365 2017
49
Syringocystadenoma Papilliferum of the External Auditory Canal. 61
28490727 2017
50
Syringocystadenoma Papilliferum of Sweat Gland of Caruncle: A Unique Case Report. 61
28936056 2017

Variations for Syringocystadenoma Papilliferum

Expression for Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for Syringocystadenoma Papilliferum

Pathways related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.91 MUC1 KRAS BRAF
2
Show member pathways
11.53 S100B KRAS GFAP
3 11.51 VIM MUC1 KRT19 DES ACTC1
4 11.33 VIM S100B GFAP
5
Show member pathways
11.29 VIM KRT19 GFAP DES
6 11.19 VIM DES ACTC1
7 10.95 KRAS BRAF
8 10.84 KRAS BRAF

GO Terms for Syringocystadenoma Papilliferum

Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.73 VIM SERPINA3 MUC1 KRT19 DES ACTC1
2 cell body GO:0044297 9.33 GFAP BRAF ACTC1
3 intermediate filament cytoskeleton GO:0045111 9.13 VIM GFAP DES
4 intermediate filament GO:0005882 8.92 VIM KRT19 GFAP DES

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 VIM KRAS BRAF ACTC1
2 astrocyte development GO:0014002 9.32 VIM GFAP
3 Bergmann glial cell differentiation GO:0060020 9.26 VIM GFAP
4 intermediate filament-based process GO:0045103 9.16 VIM GFAP
5 muscle filament sliding GO:0030049 9.13 VIM DES ACTC1
6 intermediate filament organization GO:0045109 8.8 VIM GFAP DES

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 VIM S100B KRAS GFAP DES BRAF
2 structural constituent of cytoskeleton GO:0005200 8.92 VIM KRT19 GFAP DES

Sources for Syringocystadenoma Papilliferum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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