MCID: SYR002
MIFTS: 45

Syringocystadenoma Papilliferum

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Syringocystadenoma Papilliferum

MalaCards integrated aliases for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 12 76 53 59 15 73
Fistulous Vegetative Verrucous Hydradenoma 53 59
Naevus Syringocystadenomatosus Papilliferus 59
Syringadenoma Papilliferum 59
Papillary Syringadenoma 12
Papillary Hidradenoma 73
Scap 59

Characteristics:

Orphanet epidemiological data:

59
syringocystadenoma papilliferum
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:5445
NCIt 50 C4172
SNOMED-CT 68 239121009 8934006
Orphanet 59 ORPHA840
UMLS via Orphanet 74 C0406803
ICD10 via Orphanet 34 D23.9
UMLS 73 C0406803

Summaries for Syringocystadenoma Papilliferum

MalaCards based summary : Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to apocrine adenoma and hidradenoma. An important gene associated with Syringocystadenoma Papilliferum is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are ERK Signaling and Cytoskeletal Signaling. Affiliated tissues include skin and lung, and related phenotypes are subcutaneous nodule and sparse scalp hair

Wikipedia : 76 Syringocystadenoma papilliferum (also known as \"syringadenoma papilliferum\") is a benign apocrine... more...

Related Diseases for Syringocystadenoma Papilliferum

Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 apocrine adenoma 31.6 KRAS MUC1
2 hidradenoma 30.7 MUC1 VIM
3 adenosquamous carcinoma 30.0 KRAS MUC1
4 cutaneous leiomyosarcoma 29.2 ACTC1 DES GFAP MUC1
5 leiomyosarcoma 28.2 ACTC1 DES S100B VIM
6 syringoma 27.7 DES GFAP MUC1 S100B VIM
7 anaplastic ganglioglioma 10.6 ACTC1 GFAP
8 adenoma 10.6
9 hyperplastic polyposis syndrome 10.6 BRAF KRAS
10 mature teratoma 10.6 BRAF KRAS
11 colonic benign neoplasm 10.6 BRAF KRAS
12 binswanger's disease 10.5 ACTC1 GFAP
13 necrotizing sialometaplasia 10.5 ACTC1 GFAP
14 gliomatosis peritonei 10.5 DES GFAP
15 pleomorphic xanthoastrocytoma 10.5 BRAF GFAP
16 ampulla of vater neoplasm 10.5 KRAS MUC1
17 pulmonary blastoma 10.5 DES KRAS
18 clear cell meningioma 10.5 GFAP MUC1
19 appendix cancer 10.5 KRAS MUC1
20 basal cell carcinoma 1 10.5
21 basal cell carcinoma 10.5
22 ovarian fibrothecoma 10.5 ACTC1 DES
23 biliary papillomatosis 10.5 KRAS MUC1
24 fibroblastic rheumatism 10.5 ACTC1 DES
25 colloid carcinoma of the pancreas 10.4 KRAS MUC1
26 botryoid rhabdomyosarcoma 10.4 ACTC1 DES
27 pulmonic stenosis 10.4 BRAF KRAS
28 pulmonary vein stenosis 10.4 ACTC1 DES
29 cystic nephroma 10.4 ACTC1 DES
30 biliary tract neoplasm 10.4 KRAS MUC1
31 schimmelpenning-feuerstein-mims syndrome 10.4
32 duodenum cancer 10.4 KRAS MUC1
33 pseudomyxoma peritonei 10.4 KRAS MUC1
34 skin squamous cell carcinoma 10.3 BRAF KRAS
35 lymphangiectasis 10.3 ACTC1 VIM
36 ependymoblastoma 10.3 GFAP VIM
37 chickenpox 10.3 ACTC1 MUC1
38 astroblastoma 10.3 GFAP VIM
39 glomangiomyoma 10.3 ACTC1 VIM
40 mucinous adenocarcinoma 10.3 KRAS MUC1
41 medulloepithelioma 10.3 GFAP VIM
42 intravascular papillary endothelial hyperplasia 10.3 ACTC1 VIM
43 medullomyoblastoma 10.3 DES GFAP
44 spindle cell thymoma 10.3 DES MUC1
45 bile duct adenocarcinoma 10.3 KRAS MUC1
46 ovarian small cell carcinoma 10.3 DES MUC1
47 liver angiosarcoma 10.3 KRAS VIM
48 proximal spinal muscular atrophy 10.3 DES MUC1
49 giant cell glioblastoma 10.3 BRAF GFAP
50 plasmablastic lymphoma 10.2 DES MUC1

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to Syringocystadenoma Papilliferum

Symptoms & Phenotypes for Syringocystadenoma Papilliferum

Human phenotypes related to Syringocystadenoma Papilliferum:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001482
2 sparse scalp hair 59 32 hallmark (90%) Very frequent (99-80%) HP:0002209
3 abnormal blistering of the skin 59 32 frequent (33%) Frequent (79-30%) HP:0008066
4 nevus sebaceous 59 32 occasional (7.5%) Occasional (29-5%) HP:0010815
5 papule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200034

GenomeRNAi Phenotypes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 MUC1 BRAF KRAS
2 Decreased viability GR00106-A-0 9.47 KRAS
3 Decreased viability GR00221-A-1 9.47 KRAS
4 Decreased viability GR00221-A-2 9.47 KRAS
5 Decreased viability GR00221-A-4 9.47 BRAF
6 Decreased viability GR00301-A 9.47 BRAF KRAS
7 Decreased viability GR00381-A-1 9.47 BRAF KRAS
8 Decreased viability GR00402-S-2 9.47 MUC1 BRAF KRAS
9 Decreased cell migration GR00055-A-1 9.26 MUC1 VIM BRAF KRAS

MGI Mouse Phenotypes related to Syringocystadenoma Papilliferum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 KRAS VIM ACTC1 BRAF DES GFAP
2 homeostasis/metabolism MP:0005376 9.5 GFAP KRAS S100B VIM ACTC1 BRAF
3 muscle MP:0005369 9.1 KRAS VIM ACTC1 BRAF DES GFAP

Drugs & Therapeutics for Syringocystadenoma Papilliferum

Search Clinical Trials , NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

Anatomical Context for Syringocystadenoma Papilliferum

MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

41
Skin, Lung

Publications for Syringocystadenoma Papilliferum

Articles related to Syringocystadenoma Papilliferum:

(show top 50) (show all 167)
# Title Authors Year
1
Dermoscopy of a rare case of linear syringocystadenoma papilliferum with review of the literature. ( 29445572 )
2018
2
Syringocystadenoma papilliferum and trichoblastoma arising in the nevus sebaceous. ( 29567896 )
2018
3
Poromas with large lumens histopathologically mimicking syringocystadenoma papilliferum: Report of three cases. ( 29943807 )
2018
4
Papillary eccrine adenoma associated with syringocystadenoma papilliferum. ( 29582790 )
2018
5
Syringocystadenoma papilliferum with coexisting hydrocystoma. ( 29536975 )
2018
6
Syringocystadenoma papilliferum on the mons pubis. ( 29906013 )
2018
7
Contiguous verrucous proliferations in syringocystadenoma papilliferum: A retrospective analysis with additional evaluation via mutation-specific BRAFV600E immunohistochemistry. ( 29206289 )
2018
8
Simultaneous Presentation of Trichilemmal Carcinoma and Syringocystadenoma Papilliferum within a Nevus Sebaceous. ( 29853758 )
2018
9
Dermoscopy of syringocystadenoma papilliferum. ( 28695704 )
2017
10
Blaschko-linear Syringocystadenoma Papilliferum: A Peculiar Presentation. ( 29204402 )
2017
11
Syringocystadenoma Papilliferum of the External Auditory Canal. ( 28490727 )
2017
12
Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. ( 29166517 )
2017
13
Eyelid syringocystadenoma papilliferum: A novel presentation with major review. ( 29053036 )
2017
14
Squamous cell carcinoma arising from syringocystadenoma papilliferum of the eyelid. ( 29217053 )
2017
15
Syringocystadenoma Papilliferum of Sweat Gland of Caruncle: A Unique Case Report. ( 28936056 )
2017
16
Syringocystadenoma Papilliferum in Coexistence With Verrucous Carcinoma on the Face. ( 29112527 )
2017
17
A Case of Syringocystadenoma Papilliferum with Tubular Papillary Adenoma of the Chest. ( 28502963 )
2017
18
Syringocystadenoma Papilliferum of the Scalp Arising from a Nevus Sebaceous. ( 27761094 )
2016
19
Syringocystadenoma papilliferum of the external auditory canal. Case report and literature review. ( 27658577 )
2016
20
Syringocystadenoma papilliferum with multiple lung metastases and long survival. ( 27837643 )
2016
21
Linear syringocystadenoma papilliferum on the retroauricular area associated with nevus sebaceus. ( 28329571 )
2016
22
Tubulopapillary Cystic Adenoma With Apocrine Differentiation: A Unifying Concept for Syringocystadenoma Papilliferum, Apocrine Gland Cyst, and Tubular Papillary Adenoma. ( 28033156 )
2016
23
Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma, and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus. ( 25761672 )
2015
24
Tricholemmoma, sebaceoma, syringocystadenoma papilliferum, basal cell carcinoma, trichilemmal cyst arising within a nevus sebaceous. ( 26224239 )
2015
25
Eruptive Syringocystadenoma Papilliferum, Keratoacanthoma, and Verruca Vulgaris in a Keratinocytic Epidermal Nevus on the Leg. ( 26790513 )
2015
26
Syringocystadenoma papilliferum arising on naevus sebaceus: A 6-year-old child case described with dermoscopic features. ( 25900640 )
2015
27
Somatic V600E BRAF Mutation in Linear and Sporadic Syringocystadenoma Papilliferum. ( 25950823 )
2015
28
Syringocystadenoma papilliferum of the male nipple. ( 26269194 )
2015
29
Fifteen year natural history of lower eyelid syringocystadenoma papilliferum in a young girl. ( 26097022 )
2015
30
Cytological diagnosis of syringocystadenoma papilliferum a rare adnexal tumor. ( 26229253 )
2015
31
A case of syringocystadenoma papilliferum of eyelid with literature review. ( 26265653 )
2015
32
Multiple pigmented trichoblastomas, sebaceous carcinoma and syringocystadenoma papilliferum arising within a nevus sebaceous. ( 25906325 )
2015
33
Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum. ( 25532942 )
2015
34
Syringocystadenoma papilliferum in an unusual location. ( 26734876 )
2015
35
Basal Cell Carcinoma and Syringocystadenoma Papilliferum Arising in Nevus Sebaceous on Face-A Rare Entity. ( 26677302 )
2015
36
Somatic BRAF c.1799T>A p.V600E Mosaicism syndrome characterized by a linear syringocystadenoma papilliferum, anaplastic astrocytoma, and ocular abnormalities. ( 26360803 )
2015
37
Syringocystadenoma papilliferum of the upper lip. ( 25364565 )
2014
38
Syringocystadenoma papilliferum: an unusual presentation. ( 24995228 )
2014
39
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. ( 24629369 )
2014
40
Linear syringocystadenoma papilliferum on female breast: a rare appendageal tumour on an uncommon location. ( 25756479 )
2014
41
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. ( 23762705 )
2013
42
Follicular hybrid cyst with isthmic-catagen, pilomatrical, and syringocystadenoma papilliferum components. ( 22699865 )
2013
43
A case of syringocystadenoma papilliferum on lower leg: a rare location. ( 24082194 )
2013
44
Linear syringocystadenoma papilliferum: a case report with review of literature. ( 24082219 )
2013
45
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. ( 24021448 )
2013
46
Syringocystadenoma papilliferum arising on the scrotum. ( 22612442 )
2013
47
Syringocystadenoma papilliferum on the dorsum of the foot. ( 23621843 )
2013
48
Syringocystadenoma papilliferum in the right lower abdomen: a case report and review of literature. ( 23569386 )
2013
49
Syringocystadenoma papilliferum of the scalp in an adult male - a case report. ( 23730665 )
2013
50
Carcino-sarcoma in a case of syringocystadenoma papilliferum: a rare entity. ( 24765470 )
2012

Variations for Syringocystadenoma Papilliferum

Expression for Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for Syringocystadenoma Papilliferum

GO Terms for Syringocystadenoma Papilliferum

Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.76 ACTC1 BRAF DES GFAP KRAS MUC1
2 intermediate filament GO:0005882 9.13 DES GFAP VIM
3 cell body GO:0044297 8.8 ACTC1 BRAF GFAP

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 ACTC1 BRAF KRAS VIM
2 cytokine-mediated signaling pathway GO:0019221 9.63 KRAS MUC1 VIM
3 visual learning GO:0008542 9.43 BRAF KRAS
4 astrocyte development GO:0014002 9.4 GFAP VIM
5 long-term synaptic potentiation GO:0060291 9.33 BRAF GFAP S100B
6 Bergmann glial cell differentiation GO:0060020 9.32 GFAP VIM
7 intermediate filament-based process GO:0045103 9.26 GFAP VIM
8 muscle filament sliding GO:0030049 9.13 ACTC1 DES VIM
9 intermediate filament organization GO:0045109 8.8 DES GFAP VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 BRAF DES GFAP S100B VIM
2 structural constituent of cytoskeleton GO:0005200 8.8 DES GFAP VIM

Sources for Syringocystadenoma Papilliferum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....